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DJ-1

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https://www.readbyqxmd.com/read/29755640/melatonin-and-tumeric-ameliorate-aging-induced-changes-implication-of-immunoglobulins-cytokines-dj-1-nrf2-and-apoptosis-regulation
#1
Ismail Ahmed Ismail, Hanan A El-Bakry, Safaa S Soliman
Aging is associated with several biological, physiological, cellular and histological changes. In the present study, we investigated the effect of aging on different signaling pathways, including antioxidant system, apoptosis and immune status. Several natural products were used to ameliorate and block aging-related changes. Melatonin and turmeric have been known to ameliorate and decrease aging-related changes. However, the exact mechanism(s) of their action is not fully understood. In the present study, we tried to uncover the regulatory mechanism(s) by which melatonin and turmeric work against aging...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29753659/a-conserved-human-dj1-subfamily-motif-djsm-is-critical-for-anti-oxidative-and-deglycase-activities-of-plasmodium-falciparum-dj1
#2
Divya N Nair, Rajesh Prasad, Neha Singhal, Manish Bhattacharjee, Renu Sudhakar, Pushpa Singh, Subramonian Thanumalayan, Uday Kiran, Yogendra Sharma, Puran Singh Sijwali
Plasmodium falciparum DJ1 (PfDJ1) belongs to the DJ-1/ThiJ/PfpI superfamily whose members are present in all the kingdoms of life and exhibit diverse cellular functions and biochemical activities. The common feature of the superfamily is the class I glutamine amidotransferase domain with a conserved redox-active cysteine residue, which mediates various activities of the superfamily members, including anti-oxidative activity in PfDJ1 and human DJ1 (hDJ1). As the superfamily members represent diverse functional classes, to investigate if there is any sequence feature unique to hDJ1-like proteins, sequences of the representative proteins of different functional classes were compared and analysed...
May 10, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29742581/niacin-and-selenium-attenuate-brain-injury-after-cardiac-arrest-in-rats-by-up-regulating-dj-1-akt-signaling
#3
Woon Yong Kwon, Gil Joon Suh, Kyung Su Kim, Yoon Sun Jung, Sung Hee Kim, A Rum Lee, Kyoung Min You, Min Ji Park
OBJECTIVES: To determine neuroprotective effects and mechanism of the combination therapy of niacin and selenium in cardiac arrest rats. DESIGN: Prospective laboratory study. SETTING: University laboratory. SUBJECTS: Rat cortex neurons and male Sprague-Dawley rats (n = 68). INTERVENTIONS: In rat cortex neurons underwent 90 minutes of oxygen-glucose deprivation and 22.5 hours of reoxygenation, effects of the combination therapy of niacin (0...
May 8, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29740311/-sophora-flavescens-aiton-decreases-mpp-induced-mitochondrial-dysfunction-in-sh-sy5y-cells
#4
Hee-Young Kim, Hyongjun Jeon, Hyungwoo Kim, Sungtae Koo, Seungtae Kim
Sophora flavescens Aiton (SF) has been used to treat various diseases including fever and inflammation in China, South Korea and Japan. Several recent reports have shown that SF has anti-inflammatory and anti-apoptotic effects, indicating that it is a promising candidate for treatment of Parkinson's disease (PD). We evaluated the protective effect of SF against neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+ )-induced mitochondrial dysfunction in SH-SY5Y human neuroblastoma cells, an in vitro PD model. SH-SY5Y cells were incubated with SF for 24 h, after which they were treated with MPP+ ...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29734677/the-effect-of-bornyl-cis-4-hydroxycinnamate-on-melanoma-cell-apoptosis-is-associated-with-mitochondrial-dysfunction-and-endoplasmic-reticulum-stress
#5
Tzu-Yen Yang, Yu-Jen Wu, Chi-I Chang, Chien-Chih Chiu, Mei-Li Wu
Bornyl cis -4-hydroxycinnamate, an active compound isolated from Piper betle stems, was investigated in terms of its effects on A2058 and A375 melanoma cell proliferation and protein expression in this study. We used flow cytometric analysis to examine the early stages of apoptosis induced by bornyl cis -4-hydroxycinnamate in the two melanoma cell lines and employed comparative proteomic analysis to investigate the effects of this compound on protein expression in A375 cells. Master maps generated by PDQuest software from two-dimensional electrophoresis (2-DE) analysis of A375 cells showed that the expression levels of 35 proteins were significantly altered, with 18 proteins upregulated and 17 downregulated...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29728856/elevated-expression-of-dj-1-encoded-by-the-human-park7-gene-protects-neuronal-cells-from-sevoflurane-induced-neurotoxicity
#6
Yajie Zhang, Yu Li, Xuechang Han, Xu Dong, Xiangbiao Yan, Qunzhi Xing
Sevoflurane, an inhaled ether general anesthetic agent, exerts a variety of neurotoxic effects, including oxidative stress, mitochondrial dysfunction, and neuronal apoptosis. However, the underlying molecular mechanisms remain to be elucidated. DJ-1 is a protein that exerts neuroprotective effects against different kinds of stress through multiple pathways. This study aimed to investigate the neuroprotective effects of DJ-1 against sevoflurane-induced neurotoxicity. Here, we found that sevoflurane treatment significantly increased DJ-1 expression in human neuroblastoma M17 cells in a dose-dependent manner at both the mRNA and protein levels...
May 4, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29725397/diallyl-disulfide-effect-on-the-invasion-and-migration-ability-of-hl-60-cells-with-a-high-expression-of-dj-1-in-the-nucleus-through-the-suppression-of-the-src-signaling-pathway
#7
Ran Liu, Ye-Ning Yang, Lan Yi, Jing Qing, Qing-Ye Li, Wen-Song Wang, Juan Wang, Yu-Xian Tang, Hui Tan
The present study examined the effect of diallyl disulfide (DADS) on the invasion and migration ability of HL-60 cells with a high expression of parkinsonism associated deglycase (DJ-1) in the nucleus (HHDN), and its molecular mechanism. A western blot assay was used to measure the effects of DADS and an Src inhibitor on the expression of DJ-1 and the Src signal pathway in HHDN. The effects of DADS and Src inhibitors on the invasion and migration ability of HHDN was detected using Transwell migration and invasion chamber experiments...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721921/oxidative-stress-regulation-and-dj-1-function-in-the-retinal-pigment-epithelium-implications-for-amd
#8
Vera L Bonilha
In the retina, oxidative stress can initiate a cascade of events that ultimately leads to a focal loss of RPE cells and photoreceptors, a major contributing factor in geographic atrophy. Despite these implications, the molecular regulation of RPE oxidative metabolism under physiological and pathological conditions remains largely unknown. DJ-1 functions as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29719505/cellular-and-molecular-basis-of-neurodegeneration-in-parkinson-disease
#9
REVIEW
Xian-Si Zeng, Wen-Shuo Geng, Jin-Jing Jia, Lei Chen, Peng-Peng Zhang
It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in 1817. The disease is the second most common neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although the pathogenesis of PD is still unknown, the research findings from scientists are conducive to understand the pathological mechanisms. It is well accepted that both genetic and environmental factors contribute to the onset of PD. In this review, we summarize the mutations of main seven genes (α-synuclein, LRRK2, PINK1, Parkin, DJ-1, VPS35 and GBA1) linked to PD, discuss the potential mechanisms for the loss of dopaminergic neurons (dopamine metabolism, mitochondrial dysfunction, endoplasmic reticulum stress, impaired autophagy, and deregulation of immunity) in PD, and expect the development direction for treatment of PD...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29710464/cistanche-deserticola-polysaccharides-protects-pc12-cells-against-ogd-rp-induced-injury
#10
Yue Liu, Hui Wang, Mei Yang, Ning Liu, Yuping Zhao, Xue Qi, Yang Niu, Tao Sun, Yuxiang Li, Jianqiang Yu
Ischemia stroke is a disease with high morbidity and mortality. Cistanche deserticola polysaccharides (CDP) possess a wide range of beneficial effects, including hepatoprotection and immune homeostasis. As far as we know, the protective effect of CDP on neurons injured by oxygen-glucose deprivation/reperfusion (OGD/RP) has not been investigated. In this study, OGD/RP injured a PC12 cell model. Briefly, CDP (0.05, 0.5 and 5??g/ml) was administered before reperfusion. The protective effect of CDP was then evaluated on the basis of cell viability, lactate dehydrogenase (LDH) leakage, [Ca2+ ]i , mitochondrial membrane potential (MMP)and cell apoptosis, and redox status after reperfusion was evaluated by assaying reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29709570/zinc-mediated-reversible-multimerization-of-hsp31-enhances-the-activity-of-holding-chaperone
#11
Jihong Kim, Dongwook Choi, So-Young Cha, Young-Mee Oh, Eunha Hwang, Chankyu Park, Kyoung-Seok Ryu
Hsp31 protein, belonging to the DJ-1/ThiJ/PfpI superfamily, increases the survival of Escherichia coli under various stresses. While it was reported as a holding chaperone, Hsp31 was also shown to exhibit the glyoxalase III activity in subsequent study. Here, we describe our finding that Hsp31 undergoes a Zn+2 -mediated multimerization (HMWZinc ), resulting in an enhanced chaperone activity. Furthermore, it was shown that the formation of HMWZinc is reversible such that the oligomer dissociates into the native dimer by EDTA incubation...
April 27, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29701902/low-doses-of-paclitaxel-repress-breast-cancer-invasion-through-dj-1-klf17-signaling-pathway
#12
Ismail Ahmed Ismail, Gamal H El-Sokkary, Saber H Saber
Paclitaxel (taxol) is an important agent against many tumors, including breast cancer. Ample data documents that paclitaxel inhibits breast cancer metastasis while others prove that paclitaxel enhances breast cancer metastasis. The mechanisms by which paclitaxel exerts its action are not well established. This study focused on the effect of paclitaxel, particularly the low doses on breast cancer metastasis and the mechanisms that regulate it. Current results show that, paclitaxel exerts significant cytotoxicity even at low doses in both MCF-7 and MDA-MB-231 cells...
April 27, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29700116/comparative-analysis-of-parkinson-s-disease-associated-genes-reveals-altered-survival-and-bioenergetics-of-parkin-deficient-dopamine-neurons-in-mice
#13
Nicolas Giguere, Consiglia Pacelli, Caroline Saumure, Marie-Josee Bourque, Diana Matheoud, Daniel Levesque, Ruth S Slack, David S Park, Louis-Eric Trudeau
Many mutations in genes encoding proteins such as parkin, PTEN-induced putative kinase 1 (PINK1), protein deglycase DJ-1 (DJ-1 or PARK7), leucine-rich repeat kinase 2 (LRRK2), and α-synuclein have been linked to familial forms of Parkinson's disease (PD). The consequences of these mutations, such as altered mitochondrial function and pathological protein aggregation, are starting to be better understood. However, little is known about the mechanisms explaining why alterations in such diverse cellular mechanisms lead to the selective loss of dopamine (DA) neurons in the substantia nigra (SNc) in the brain of individuals with PD...
April 26, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29697031/tpen-exerts-antitumor-efficacy-in-murine-mammary-adenocarcinoma-through-an-h2o2-signaling-mechanism-dependent-on-caspase-3
#14
Viviana Soto-Mercado, Miguel Mendivil-Perez, Claudia Uruena-Pinzon, Susana Fiorentino, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
BACKGROUND: Breast cancer is the second most common cancer worldwide. N, N, N', N'-Tetrakis (2-pyridylmethyl)-ethylenediamine (TPEN) is a lipid-soluble zinc metal chelator that induces apoptosis in cancer cells through oxidative stress (OS). However, the effectiveness and the mechanisms involved in TPEN-induced cell death in mammary adenocarcinoma cells in vitro and in vivo are still unclear. OBJECTIVE: This study aimed to evaluate the cytotoxic effect of TPEN in mouse embryonic fibroblasts (MEFs, as normal control cells) and mammary adenocarcinoma cancer cells (TS/A cells) in vitro and in a mammary tumor model in vivo...
April 25, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29675578/the-parkinson-s-disease-linked-protein-dj-1-associates-with-cytoplasmic-mrnp-granules-during-stress-and-neurodegeneration
#15
Mariaelena Repici, Mahdieh Hassanjani, Daniel C Maddison, Pedro Garção, Sara Cimini, Bhavini Patel, Éva M Szegö, Kornelis R Straatman, Kathryn S Lilley, Tiziana Borsello, Tiago F Outeiro, Lia Panman, Flaviano Giorgini
Mutations in the gene encoding DJ-1 are associated with autosomal recessive forms of Parkinson's disease (PD). DJ-1 plays a role in protection from oxidative stress, but how it functions as an "upstream" oxidative stress sensor and whether this relates to PD is still unclear. Intriguingly, DJ-1 may act as an RNA binding protein associating with specific mRNA transcripts in the human brain. Moreover, we previously reported that the yeast DJ-1 homolog Hsp31 localizes to stress granules (SGs) after glucose starvation, suggesting a role for DJ-1 in RNA dynamics...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29667128/epigallocatechin-3-gallate-protects-and-prevents-paraquat-induced-oxidative-stress-and-neurodegeneration-in-knockdown-dj-1-%C3%AE-drosophila-melanogaster
#16
Daniel A Martinez-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Epigallocatechin-3-gallate (EGCG) is a polyhydroxyphenol constituent of green tea (e.g., Camellia sinensis) with known antioxidant properties. Due to these properties, others have proposed it as a potential therapeutic agent for the treatment of Parkinson's disease (PD). Previously, we demonstrated that EGCG prolonged the lifespan and locomotor activity in wild-type Canton-S flies exposed to the neurotoxicant paraquat (PQ), suggesting neuroprotective properties. Both gene mutations and environmental neurotoxicants (e...
April 17, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29649621/astrocyte-specific-dj-1-overexpression-protects-against-rotenone-induced-neurotoxicity-in-a-rat-model-of-parkinson-s-disease
#17
Briana R De Miranda, Emily M Rocha, Qing Bai, Amina El Ayadi, David Hinkle, Edward A Burton, J Timothy Greenamyre
DJ-1 is a redox-sensitive protein with several putative functions important in mitochondrial physiology, protein transcription, proteasome regulation, and chaperone activity. High levels of DJ-1 immunoreactivity are reported in astrocytes surrounding pathology associated with idiopathic Parkinson's disease, possibly reflecting the glial response to oxidative damage. Previous studies showed that astrocytic over-expression of DJ-1 in vitro prevented oxidative stress and mitochondrial dysfunction in primary neurons...
July 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29615894/trpc1-deletion-causes-striatal-neuronal-cell-apoptosis-and-proteomic-alterations-in-mice
#18
Dian Wang, Haitao Yu, Benhong Xu, Hua Xu, Zaijun Zhang, Xiaohu Ren, Jianhui Yuan, Jianjun Liu, Yi Guo, Peter S Spencer, Xifei Yang
Transient receptor potential channel 1 (TRPC1) is widely expressed throughout the nervous system, while its biological role remains unclear. In this study, we showed that TRPC1 deletion caused striatal neuronal loss and significantly increased TUNEL-positive and 8-hydroxy-2'-deoxyguanosine (8-OHdG) staining in the striatum. Proteomic analysis by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS) revealed a total of 51 differentially expressed proteins (26 increased and 25 decreased) in the stratum of TRPC1 knockout (TRPC1-/- ) mice compared to that of wild type (WT) mice...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29599708/distinct-mechanisms-of-pathogenic-dj-1-mutations-in-mitochondrial-quality-control
#19
Daniela Strobbe, Alexis A Robinson, Kirsten Harvey, Lara Rossi, Caterina Ferraina, Valerio de Biase, Carlo Rodolfo, Robert J Harvey, Michelangelo Campanella
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7 , encoding DJ-1, are associated with early-onset familial Parkinson's disease and lead to pathological oxidative stress and/or disrupted protein degradation by the proteasome. The aim of this study was to gain insights into the pathogenic mechanisms of selected DJ-1 missense mutations, by characterizing protein-protein interactions, core parameters of mitochondrial function, quality control regulation via autophagy, and cellular death following dopamine accumulation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29559831/dj-1-in-ocular-diseases-a-review
#20
REVIEW
Cong Liu, Xiufen Liu, Jing Qi, Om Prakash Pant, Cheng-Wei Lu, Jilong Hao
Protein deglycase DJ-1 (Parkinson disease protein 7) is a 20 kDa protein encoded by PARK7 gene. It is also known as a redox-sensitive chaperone and sensor that protect cells against oxidative stress-induced cell death in many human diseases. Though increasing evidence implicates that DJ-1 may also participate in ocular diseases, the overview of DJ-1 in ocular diseases remains elusive. In this review, we discuss the role as well as the underlying molecular mechanisms of DJ-1 in ocular diseases, including Fuchs endothelial corneal dystrophy (FECD), age-related macular degeneration (AMD), cataracts, and ocular neurodegenerative diseases, highlighting that DJ-1 may serve as a very striking therapeutic target for ocular diseases...
2018: International Journal of Medical Sciences
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