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DJ-1

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https://www.readbyqxmd.com/read/28224045/dj-1-maintains-energy-and-glucose-homeostasis-by-regulating-the-function-of-brown-adipose-tissue
#1
Rong Wu, Xiao-Meng Liu, Jian-Guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-Qiu Wang, Jian-Qing Ding, Dong-Hao Li, John R Speakman, Guang Ning, Wanzhu Jin, Zengqiang Yuan
DJ-1 protein is involved in multiple physiological processes, including Parkinson's disease. However, the role of DJ-1 in the metabolism is largely unknown. Here we found that DJ-1 maintained energy balance and glucose homeostasisvia regulating brown adipose tissue (BAT) activity. DJ-1-deficient mice reduced body mass, increased energy expenditure and improved insulin sensitivity. DJ-1 deletion also resisted high-fat-diet (HFD) induced obesity and insulin resistance. Accordingly, DJ-1 transgene triggered autonomous obesity and glucose intolerance...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28213071/pla2g6-accumulates-in-lewy-bodies-in-park14-and-idiopathic-parkinson-s-disease
#2
Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
The histopathological hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is the occurrence of insoluble fibrillary aggregates known as Lewy bodies, in which phosphorylated α-synuclein (α-syn) is a major component. To date, familial PD-linked gene products, including α-syn, parkin, PINK-1, DJ-1 and LRRK2, are known to be involved in Lewy body formation. Phospholipase A2, group VI (PLA2G6) is the causative gene for PARK14-linked parkinsonism (PARK14), a familial form of juvenile-onset dystonia parkinsonism...
February 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28165637/neuroprotective-effects-of-extracellular-dj-1-on-reperfusion-injury-in-sh-sy5y-cells
#3
Jay Han, Beryl Luk, Frank J S Lee
Using an in vitro model of ischemic stroke we treated differentiated SH-SY5Y cells to oxygen-glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ-1 during reperfusion exhibited significant rescue from OGD-induced cell death.
February 6, 2017: Synapse
https://www.readbyqxmd.com/read/28101575/identification-of-potential-targets-for-differentiation-in-human-leukemia-cells-induced-by-diallyl-disulfide
#4
Hui Ling, Jie He, Hui Tan, Lan Yi, Fang Liu, Xiaoxia Ji, Youhua Wu, Haobin Hu, Xi Zeng, Xiaohong Ai, Hao Jiang, Qi Su
Diallyl disulfide (DADS) is a primary component of garlic, which has chemopreventive potential. We previously found that moderate doses (15-120 µM) of DADS induced apoptosis and G2/M phase cell cycle arrest. In this study, we observed the effect of low doses (8 µM) of DADS on human leukemia HL-60 cells. We found that DADS could inhibit proliferation, migration and invasion in HL-60 cells, and arrested cells at G0/G1 stage. Then, cell differentiation was displayed by morphologic observation, NBT reduction activity and CD11b evaluation of cytometric flow...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28092737/complex-molecular-changes-induced-by-chronic-progestogens-exposure-in-roach-rutilus-rutilus
#5
Gabor Maasz, Zita Zrinyi, Peter Takacs, Sandor Lovas, Istvan Fodor, Tibor Kiss, Zsolt Pirger
In our previous study, we measured 0.23-13.67ng/L progestogens (progesterone, drospirenone, levonorgestrel) in natural waters in the catchment area of the largest shallow lake of Central Europe, Lake Balaton. Progestogen contaminations act as potent steroids with mixed progestagenic, androgenic and mild estrogenic effects that is why our aim was to investigate the morphological and molecular effects of mixture of progesterone, drospirenone, and levonorgestrel in environmentally relevant (10ng/L) and higher (50 and 500ng/L) exposure concentrations in common roach, Rutilus rutilus...
January 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28088625/absence-of-dj-1-causes-age-related-retinal-abnormalities-in-association-with-increased-oxidative-stress
#6
Vera L Bonilha, Brent A Bell, Mary E Rayborn, Ivy S Samuels, Anna King, Joe G Hollyfield, Chengsong Xie, Huaibin Cai
Oxidative stress alters physiological function in most biological tissues and can lead to cell death. In the retina, oxidative stress initiates a cascade of events leading to focal loss of RPE and photoreceptors, which is thought to be a major contributing factor to geographic atrophy. Despite these implications, the molecular regulation of RPE oxidative stress under normal and pathological conditions remains largely unknown. A better understanding of the mechanisms involved in regulating RPE and photoreceptors oxidative stress response is greatly needed...
March 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28074428/tat-dj-1-enhances-cell-survival-by-inhibition-of-oxidative-stress-nf-%C3%AE%C2%BAb-and-mapk-activation-in-hepg2-cells
#7
Hyo Sang Jo, Eun Ji Yeo, Min Jea Shin, Yeon Joo Choi, Hyeon Ji Yeo, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Won Sik Eum, Soo Young Choi
OBJECTIVES: To identify the protective effect of DJ-1 protein against oxidative stress-induced HepG2 cell death, we used cell-permeable wild type (WT) and a mutant (C106A Tat-DJ-1) protein. RESULTS: By using western blotting and fluorescence microscopy, we observed WT and C106A Tat-DJ-1 proteins were efficiently transduced into HepG2 cells. Transduced WT Tat-DJ-1 proteins increased cell survival and protected against DNA fragmentation and intracellular ROS generation levels in H2O2-exposed HepG2 cells...
January 10, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28069874/dimethyl-fumarate-controls-the-nrf2-dj-1-axis-in-cancer-cells-therapeutic-applications
#8
Nathaniel Edward Bennett Saidu, Gaëlle Noé, Olivier Cerles, Luc Cabel, Niloufar Kavian-Tessler, Sandrine Chouzenoux, Mathilde Bahuaud, Christiane Chéreau, Carole Nicco, Karen Leroy, Bruno Borghese, Francois Goldwasser, Frédéric Batteux, Jerome Alexandre
The transcription factor NRF2 (NFE2L2), regulates important antioxidant and cytoprotective genes. It enhances cancer cell proliferation and promotes chemoresistance in several cancers. Dimethyl fumarate (DMF) is known to promote NRF2 activity in non-cancer models. We combined in vitro and in vivo methods to examine the effect of DMF on cancer cell death and the activation of the NRF2 antioxidant pathway. We demonstrated that at lower concentrations (< 25 μM), DMF has a cytoprotective role through activation of the NRF2 antioxidant pathway...
January 9, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28067625/pituitary-adenylate-cyclase-activating-polypeptide-pacap-has-neuroprotective-function-in-dopamine-based-neurodegeneration-developed-in-two-parkinsonian-models
#9
G Maasz, Z Zrinyi, D Reglodi, D Petrovics, A Rivnyak, T Kiss, A Jungling, A Tamas, Z Pirger
It has been observed that pituitary-adenylate cyclase activating polypeptide (PACAP) rescued DAergic neurons from neurodegeneration and improved motor alterations induced by 6-hydroxy-dopamine (6-OHDA) in rat parkinsonian models. Recently we investigated the molecular background of the neuroprotective effect of PACAP in DA-based neurodegeneration using rotenone-induced snail and 6-OHDA-induced rat models of Parkinson's disease. The behavioural activity, monoamine (DA and serotonin), metabolic enzyme (S-COMT, MB-COMT and MAO-B) and PARK7/DJ-1 protein contents were measured before and after PACAP-treatment in both models...
December 22, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28042771/oxidative-stress-pro-inflammatory-cytokines-and-antioxidants-regulate-expression-levels-of-micrornas-in-parkinson-s-disease
#10
Kedar N Prasad
Parkinson's disease (PD) is a slow progressive neurodegenerative disease associated with abnormal function of extrapyramidal system. Although several biochemical and genetic defects have been identified, increased oxidative stress and chronic inflammation are one of the earliest events that initiate and promote PD. Oxidative stress also participates in impaired non-motor symptoms.The levels of microRNAs that are evolutionarily conserved single-stranded non-coding RNAs of approximately 22 nucleotide in length are altered in PD...
January 2, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28036277/dj-1-promotes-development-of-den-induced-hepatocellular-carcinoma-and-proliferation-of-liver-cancer-cells
#11
Bijun Qiu, Junqi Wang, Yingxue Yu, Chao Zhen, Jinyang Gu, Wenjun Liu, Yankai Wen, Lili Chen, Yueqiu Gao, Qiang Xia, Xiaoni Kong
Chronic liver inflammation and injuries play a critical role in development of hepatocellular carcinoma (HCC). Parkinson disease (autosomal recessive, early onset) 7, encoding PARK7 protein (also called DJ-1), plays important roles in many carcinogenesis processes and is essential in modulating inflammation. However, whether DJ-1 is involved in HCC development remains largely unknown. To determine the effect of DJ-1 on HCC development, we accessed the correlation of hepatic DJ-1 expression with overall survival (OS) and TNM stage in 96 HCC patients and found a significant inverse correlation between DJ-1 expression and OS...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28035392/involvement-of-dj%C3%A2-1-in-ischemic-preconditioning%C3%A2-induced-delayed-cardioprotection-in-vivo
#12
Huan Wang, Yuan-Yuan Li, Ling-Yu Qiu, Yu-Feng Yan, Zhang-Ping Liao, He-Ping Chen
DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion)...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28013050/parkinsonism-associated-protein-dj-1-is-a-bona-fide-deglycase
#13
Gilbert Richarme, Julien Dairou
We discovered recently that Parkinsonism-associated DJ-1 and its bacterial homologs function as protein deglycases that repair glyoxal- and methylglyoxal-glycated proteins. Protein glycation levels are 2- to 10-fold increased in deglycase-depleted cells, and deglycase mutants display up to 500-fold loss of viability in methylglyoxal or glucose-containing media, suggesting that these deglycases play important roles in protecting cells against electrophile and carbonyl stress. Although the deglycase activity of DJ-1 is well supported by extensive biochemical work, Pfaff et al...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27994224/cardioprotective-effects-of-cu-ii-atsm-in-human-vascular-smooth-muscle-cells-and-cardiomyocytes-mediated-by-nrf2-and-dj-1
#14
Salil Srivastava, Philip J Blower, Aisah A Aubdool, Robert C Hider, Giovanni E Mann, Richard C Siow
Cu((II))ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu((II))ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu((II))ATSM activates the redox-sensitive transcription factor Nrf2 in human coronary artery smooth muscle cells (HCASMC) and cardiac myocytes (HCM), leading to upregulation of antioxidant defense enzymes. Oral delivery of Cu((II))ATSM in mice induced expression of the Nrf2-regulated enzymes in the heart and aorta...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27989121/short-carboxylic-acid-carboxylate-hydrogen-bonds-can-have-fully-localized-protons
#15
Jiusheng Lin, Edwin Pozharski, Mark A Wilson
Short hydrogen bonds (H-bonds) have been proposed to play key functional roles in several proteins. The location of the proton in short H-bonds is of central importance, as proton delocalization is a defining feature of low-barrier hydrogen bonds (LBHBs). Experimentally determining proton location in H-bonds is challenging. Here, bond length analysis of atomic (1.15-0.98 Å) resolution X-ray crystal structures of the human protein DJ-1 and its bacterial homologue, YajL, was used to determine the protonation states of H-bonded carboxylic acids...
December 30, 2016: Biochemistry
https://www.readbyqxmd.com/read/27984092/the-budding-yeast-orthologue-of-parkinson-s-disease-associated-dj-1-is-a-multi-stress-response-protein-protecting-cells-against-toxic-glycolytic-products
#16
Urszula Natkańska, Adrianna Skoneczna, Marzena Sieńko, Marek Skoneczny
Saccharomyces cerevisiae Hsp31p is a DJ-1/ThiJ/PfpI family protein that was previously shown to be important for survival in the stationary phase of growth and under oxidative stress. Recently, it was identified as a chaperone or as glutathione-independent glyoxalase. To elucidate the role played by this protein in budding yeast cells, we investigated its involvement in the protection against diverse environmental stresses. Our study revealed that HSP31 gene expression is controlled by multiple transcription factors, including Yap1p, Cad1p, Msn2p, Msn4p, Haa1p and Hsf1p...
October 27, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27975168/molecular-alterations-in-the-cerebellum-of-sporadic-creutzfeldt-jakob-disease-subtypes-with-dj-1-as-a-key-regulator-of-oxidative-stress
#17
Waqas Tahir, Saima Zafar, Franc Llorens, Amandeep Singh Arora, Katrin Thüne, Matthias Schmitz, Nadine Gotzmann, Niels Kruse, Brit Mollenhauer, Juan Maria Torres, Olivier Andréoletti, Isidre Ferrer, Inga Zerr
Cerebellar damage and granular and Purkinje cell loss in sporadic Creutzfeldt-Jakob disease (sCJD) highlight a critical involvement of the cerebellum during symptomatic progression of the disease. In this project, global proteomic alterations in the cerebellum of brain from the two most prevalent subtypes (MM1 and VV2) of sCJD were studied. Two-dimensional gel electrophoresis (2DE) coupled mass spectrometric identification revealed 40 proteins in MM1 and 43 proteins in VV2 subtype to be differentially expressed...
December 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27966490/ayurvedic-amalaki-rasayana-promotes-improved-stress-tolerance-and-thus-has-anti-aging-effects-in-drosophila-melanogaster
#18
Vibha Dwivedi, Subhash C Lakhotia
Amalaki Rasayana (AR) is a common Ayurvedic herbal formulation of Phyllanthus emblica fruits and some other ingredients, and is used for general good health and healthy aging. We reported it to improve life history traits and to suppress neurodegeneration as well as induced apoptosis in Drosophila. The present study examines responses of Drosophila reared on AR-supplemented food to crowding, thermal or oxidative stresses. Wild-type larvae/flies reared on AR-supplemented food survived the various cell stresses much better than those reared on control food...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27903648/evidence-against-a-role-for-the-parkinsonism-associated-protein-dj-1-in-methylglyoxal-detoxification
#19
Daniel H Pfaff, Thomas Fleming, Peter Nawroth, Aurelio A Teleman
Methylglyoxal (MG) is a reactive metabolite that forms adducts on cysteine, lysine and arginine residues of proteins, thereby affecting their function. Methylglyoxal is detoxified by the Glyoxalase system, consisting of two enzymes, Glo1 and Glo2, that act sequentially to convert MG into d-lactate. Recently, the Parkinsonism-associated protein DJ-1 was described in vitro to have glyoxalase activity, thereby detoxifying the MG metabolite, or deglycase activity, thereby removing the adduct formed by MG on proteins...
January 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27868407/-effect-of-dj-1-silencing-by-rna-interference-on-growth-of-xenografted-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-in-nude-mice
#20
Zhisen Shen, Hongxia Deng, Dong Ye, Jian Zhang, Shijie Qiu, Qun Li, Xiang Cui
Objective: To investigate the effect of silencing DJ-1 on xenografted human laryngeal squamous cell carcinoma (LSCC) Hep-2 cells in nude mice. Methods: Xenograft model of human LSCC was established by subcutaneous transplantation of Hep-2 cells in 24 nude mice. The LSCC-bearing nude mice were randomly divided into 3 groups (n=8 in each):DJ-1 siRNA low dose group and DJ-1 siRNA high dose group were injected in tumors with 20 μg of DJ-1 siRNA or 40 μg of DJ-1 siRNA in 50 μL, respectively; control group was injected with 5% glucose solution in 50 μL, twice a week for 3 weeks...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
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