keyword
MENU ▼
Read by QxMD icon Read
search

Parkinson's- dj-1

keyword
https://www.readbyqxmd.com/read/27903648/evidence-against-a-role-for-the-parkinsonism-associated-protein-dj-1-in-methylglyoxal-detoxification
#1
Daniel H Pfaff, Thomas Fleming, Peter Nawroth, Aurelio A Teleman
Methylglyoxal (MG) is a reactive metabolite that forms adducts on lysine and arginine residues of proteins, thereby affecting their function. Methylglyoxal is detoxified by the Glyoxalase system, consisting of two enzymes, Glo1 and Glo2, that act sequentially to convert MG into D-lactate. Recently, the Parkinsonism-associated protein DJ-1 was described in vitro to have glyoxalase activity, thereby detoxifying the MG metabolite, or deglycase activity, thereby removing the adduct formed by MG on proteins. Since Drosophila is an established model system to study signaling, neurodegeneration and metabolic regulation in vivo, we asked whether DJ-1 contributes to MG detoxification in vivo...
November 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27818248/genetics-of-parkinson-s-disease
#2
REVIEW
Christina M Lill
Almost two decades after the identification of SNCA as the first causative gene in Parkinson's disease (PD) and the subsequent understanding that genetic factors play a substantial role in PD development, our knowledge of the genetic architecture underlying this disease has vastly improved. Approximately 5-10% of patients suffer from a monogenic form of PD where autosomal dominant mutations in SNCA, LRRK2, and VPS35 and autosomal recessive mutations in PINK1, DJ-1, and Parkin cause the disease with high penetrance...
December 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27802241/modulation-of-parkinson-s-disease-associated-protein-rescues-alzheimer-s-disease-degeneration
#3
Akihiko Nunomura, Xiongwei Zhu, George Perry
DJ-1, a causative gene product of an autosomal recessive familial form of Parkinson's disease (PD), plays roles in reducing oxidative stress and transcriptional regulation. Loss of its function is thought to result in the onset of PD. DJ-1 has been demonstrated to show general cytoprotective function mainly through antioxidant properties and possibly regulates the extent of stroke-induced damage and neurodegeneration in Alzheimer's disease (AD). The paper, "Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease", by Kitamura et al...
October 12, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27769868/oxidative-stress-a-major-pathogenesis-and-potential-therapeutic-target-of-antioxidative-agents-in-parkinson-s-disease-and-alzheimer-s-disease
#4
REVIEW
Tianfang Jiang, Qian Sun, Shengdi Chen
Oxidative stress reflects an imbalance between the overproduction and incorporation of free radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free radicals produced by oxidative stress are one of the common features in several experimental models of diseases. Free radicals affect both the structure and function of neural cells, and contribute to a wide range of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although the precise mechanisms that result in the degeneration of neurons and the relevant pathological changes remain unclear, the crucial role of oxidative stress in the pathogenesis of neurodegenerative diseases is associated with several proteins (such as α-synuclein, DJ-1, Amyloid β and tau protein) and some signaling pathways (such as extracellular regulated protein kinases, phosphoinositide 3-kinase/Protein Kinase B pathway and extracellular signal-regulated kinases 1/2) that are tightly associated with the neural damage...
December 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27766037/deficiency-of-dj-1-ameliorates-liver-fibrosis-through-inhibition-of-hepatic-ros-production-and-inflammation
#5
Yingxue Yu, Xuehua Sun, Jinyang Gu, Chang Yu, Yankai Wen, Yueqiu Gao, Qiang Xia, Xiaoni Kong
Liver fibrosis is a global health problem and previous studies have demonstrated that reactive oxygen species (ROS) play important roles in fibrogenesis. Parkinson disease (autosomal recessive, early onset) 7 (Park7) also called DJ-1 has an essential role in modulating cellular ROS levels. DJ-1 therefore may play functions in liver fibrogenesis and modulation of DJ-1 may be a promising therapeutic approach. Here, wild-type (WT) and DJ-1 knockout (DJ-1 KO) mice were administrated with carbon tetrachloride (CCl4) to induce liver fibrosis or acute liver injury...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27763504/neuroprotective-effect-of-the-marine-derived-compound-11-dehydrosinulariolide-through-dj-1-related-pathway-in-in-vitro-and-in-vivo-models-of-parkinson-s-disease
#6
Chien-Wei Feng, Han-Chun Hung, Shi-Ying Huang, Chun-Hong Chen, Yun-Ru Chen, Chun-Yu Chen, San-Nan Yang, Hui-Min David Wang, Ping-Jyun Sung, Jyh-Horng Sheu, Kuan-Hao Tsui, Wu-Fu Chen, Zhi-Hong Wen
Parkinson's disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and gait impairment. In a previous study, we found that the marine-derived compound 11-dehydrosinulariolide (11-de) upregulates the Akt/PI3K pathway to protect cells against 6-hydroxydopamine (6-OHDA)-mediated damage. In the present study, SH-SY5Y, zebrafish and rats were used to examine the therapeutic effect of 11-de. The results revealed the mechanism by which 11-de exerts its therapeutic effect: the compound increases cytosolic or mitochondrial DJ-1 expression, and then activates the downstream Akt/PI3K, p-CREB, and Nrf2/HO-1 pathways...
October 17, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27761515/swath-ms-proteome-profiling-data-comparison-of-dj-1-parkin-and-pink1-knockout-rat-striatal-mitochondria
#7
Kelly L Stauch, Lance M Villeneuve, Phillip R Purnell, Sanjit Pandey, Chittibabu Guda, Howard S Fox
This article reports changes in the striatal non-synaptic mitochondrial proteome of DJ-1, Parkin, and PINK1 knockout (KO) rats at 3 months of age. DJ-1, Parkin, and PINK1 mutations cause autosomal-recessive parkinsonism. It is thought that loss of function of these proteins contributes to the onset and pathogenesis of Parkinson׳s disease (PD). As DJ-1, Parkin, and PINK1 have functions in the regulation of mitochondria, the dataset generated here highlights protein expression changes, which can be helpful for understanding pathological mitochondrial alterations...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27748821/subcellular-localization-of-dj-1-in-human-hl-60-leukemia-cells-in-response-to-diallyl-disulfide-treatment
#8
Qingye Li, Yuxian Tang, Jing Qin, Lan Yi, Yening Yang, Juan Wang, Jie He, Qi Su, Hui Tan
Diallyl disulfide (DADS) has been demonstrated to exert potent anticancer effects in vitro and in vivo. Previous studies indicate that DADS may induce the differentiation and/or apoptosis of human leukemia cells in vitro. However, the mechanisms underlying these anticancer effects remain elusive. The aim of the present study was to investigate alterations in the subcellular localization of protein deglycase DJ‑1 (also known as Parkinsonism associated deglycase-7, PARK-7) in the cytoplasm, nucleus and mitochondria of human leukemia HL‑60 cells induced by DADS, in order to provide novel experimental evidence for the molecular mechanisms underlying the anticancer mechanisms of DADS in leukemia cells...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27734217/targeted-knockdown-of-dj-1-induces-multiple-myeloma-cell-death-via-klf6-upregulation
#9
Prahlad V Raninga, Giovanna Di Trapani, Slavica Vuckovic, Kathryn F Tonissen
Multiple myeloma (MM) is an incurable plasma B cell malignancy. Despite recent advancements in anti-MM therapies, development of drug resistance remains a major clinical hurdle. DJ-1, a Parkinson's disease-associated protein, is upregulated in many cancers and its knockdown suppresses tumor growth and overcomes chemoresistance. However, the role of DJ-1 in MM remains unknown. Using gene expression databases we found increased DJ-1 expression in MM patient cells, which correlated with shorter overall survival and poor prognosis in MM patients...
December 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27717584/parkinson-s-disease-snca-park2-and-lrrk2-targeting-micrornas-elevated-in-cingulate-gyrus
#10
Roman Tatura, Theo Kraus, Armin Giese, Thomas Arzberger, Malte Buchholz, Günter Höglinger, Ulrich Müller
INTRODUCTION: In order to better understand the role of epigenetic influences in the etiology of Parkinson's disease (PD), we studied the expression of microRNAs in gyri cinguli of patients and controls. METHODS: Expression profiling of 744 well-characterized microRNAs in gyri cinguli from patients and controls using TaqMan array microRNA cards. Verification of significantly dysregulated microRNAs by SYBR Green qRT-PCR. RESULTS: First screen by TaqMan array identified 43 microRNAs that were upregulated in gyri cinguli from patients...
September 28, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27662308/effects-of-a-dj-1-binding-compound-on-spatial-learning-and-memory-impairment-in-a-mouse-model-of-alzheimer-s-disease
#11
Yoshihisa Kitamura, Masatoshi Inden, Yasuto Kimoto, Kazuyuki Takata, Daijiro Yanagisawa, Masanori Hijioka, Eishi Ashihara, Ikuo Tooyama, Shun Shimohama, Hiroyoshi Ariga
Previously, DJ-1 modulator UCP0054278/comp-B was identified by virtual screening, where comp-B interacts with DJ-1 to produce antioxidant and neuroprotective responses in Parkinson's disease models. However, the effect of comp-B in an in vivo Alzheimer's disease (AD) model is yet undetermined. Thus, we examined the effect of comp-B on spatial learning, memory, and amyloid-β (Aβ) clearance in a transgenic mouse model of AD. We found that comp-B resolved the cognitive deficits, reduced insoluble Aβ42 levels, and prevented the degeneration of synaptic functions, thereby suggesting that comp-B may become a major compound for AD treatment...
September 21, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27619486/a-novel-tyrosine-hydroxylase-variant-in-a-group-of-chinese-patients-with-dopa-responsive-dystonia
#12
Ya-Ping Yan, Bo Zhang, Yan-Fang Mao, Zhang-Yu Guo, Jun Tian, Guo-Hua Zhao, Jia-Li Pu, Wei Luo, Zhi-Yuan Ouyang, Bao-Rong Zhang
Dopa-responsive dystonia (DRD) comprises a heterogeneous group of movement disorders. A limited number of studies of Chinese patients with DRD have been reported. In the present study, we investigated the clinical and genetic features of 12 Chinese DRD families. Point mutation analysis of the GTP-cyclohydrolase I (GCH1), tyrosine hydroxylase (TH) and sepiapterin reductase (SPR) genes was conducted by direct sequencing. In addition, multiplex ligation-dependent probe amplification targeting GCH1 and TH was performed in "mutation-free" patients...
October 5, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27613618/disease-toxicant-interactions-in-parkinson-s-disease-neuropathology
#13
Gunnar F Kwakye, Rachael A McMinimy, Michael Aschner
Human disease commonly manifests as a result of complex genetic and environmental interactions. In the case of neurodegenerative diseases, such as Parkinson's disease (PD), understanding how environmental exposures collude with genetic polymorphisms in the central nervous system to cause dysfunction is critical in order to develop better treatment strategies, therapies, and a more cohesive paradigm for future research. The intersection of genetics and the environment in disease etiology is particularly relevant in the context of their shared pathophysiological mechanisms...
September 9, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27590295/impulsive-compulsive-behaviors-in-parkin-associated-parkinson-disease
#14
Francesca Morgante, Alfonso Fasano, Monia Ginevrino, Simona Petrucci, Lucia Ricciardi, Francesco Bove, Chiara Criscuolo, Marcello Moccia, Anna De Rosa, Chiara Sorbera, Anna Rita Bentivoglio, Paolo Barone, Giuseppe De Michele, Maria Teresa Pellecchia, Enza Maria Valente
OBJECTIVE: The aim of this multicenter, case-control study was to investigate the prevalence and severity of impulsive-compulsive behaviors (ICBs) in a cohort of patients with parkin-associated Parkinson disease (PD) compared to a group of patients without the mutation. METHODS: We compared 22 patients with biallelic parkin mutations (parkin-PD) and 26 patients negative for parkin, PINK1, DJ-1, and GBA mutations (PD-NM), matched for age at onset, disease duration, levodopa, and dopamine agonist equivalent daily dose...
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27582551/novel-association-of-dj-1-with-her3-potentiates-her3-activation-and-signaling-in-cancer
#15
Shu Zhang, Seema Mukherjee, Xuejun Fan, Ahmad Salameh, Kalpana Mujoo, Zhao Huang, Leike Li, Georgina To'a Salazar, Ningyan Zhang, Zhiqiang An
HER3/ErbB3 has emerged as a new therapeutic target for cancer. Currently, more than a dozen anti-HER3 antibodies are in clinical trials for treatment of various cancers. However, limited understanding of the complex HER3 signaling in cancer and lack of established biomarkers have made it challenging to stratify cancer patients who can benefit from HER3 targeted therapies. In this study, we identified DJ-1/PARK7 (Parkinson Protein 7) as a novel interaction partner of HER3 and demonstrated the potential of DJ-1 as a biomarker for anti-HER3 cancer therapy...
August 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27563865/neuroprotective-effects-of-a-standardized-flavonoid-extract-from-safflower-against-a-rotenone-induced-rat-model-of-parkinson-s-disease
#16
Nuramatjan Ablat, Deyong Lv, Rutong Ren, Yilixiati Xiaokaiti, Xiang Ma, Xin Zhao, Yi Sun, Hui Lei, Jiamin Xu, Yingcong Ma, Xianrong Qi, Min Ye, Feng Xu, Hongbin Han, Xiaoping Pu
Parkinson's disease (PD) is a major age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra par compacta (SNpc). Rotenone is a neurotoxin that is routinely used to model PD to aid in understanding the mechanisms of neuronal death. Safflower (Carthamus tinctorius. L.) has long been used to treat cerebrovascular diseases in China. This plant contains flavonoids, which have been reported to be effective in models of neurodegenerative disease. We previously reported that kaempferol derivatives from safflower could bind DJ-1, a protein associated with PD, and that a flavonoid extract from safflower exhibited neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of PD...
August 24, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27556455/novel-redox-dependent-esterase-activity-ec-3-1-1-2-for-dj-1-implications-for-parkinson-s-disease
#17
Emmanuel Vázquez-Mayorga, Ángel G Díaz-Sánchez, Ruben K Dagda, Carlos A Domínguez-Solís, Raul Y Dagda, Cynthia K Coronado-Ramírez, Alejandro Martínez-Martínez
Mutations the in human DJ-1 (hDJ-1) gene are associated with early-onset autosomal recessive forms of Parkinson's disease (PD). hDJ-1/parkinsonism associated deglycase (PARK7) is a cytoprotective multi-functional protein that contains a conserved cysteine-protease domain. Given that cysteine-proteases can act on both amide and ester substrates, we surmised that hDJ-1 possessed cysteine-mediated esterase activity. To test this hypothesis, hDJ-1 was overexpressed, purified and tested for activity towards 4-nitrophenyl acetate (pNPA) as µmol of pNPA hydrolyzed/min/mg·protein (U/mg protein)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27534820/covalent-isg15-conjugation-positively-regulates-the-ubiquitin-e3-ligase-activity-of-parkin
#18
Eunju Im, Lang Yoo, Minju Hyun, Woo Hyun Shin, Kwang Chul Chung
Parkinson's disease (PD) is characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra and accumulation of ubiquitinated proteins in aggregates called Lewy bodies. Several mutated genes have been found in familial PD patients, including SNCA (α-synuclein), PARK2 (parkin), PINK1, PARK7 (DJ-1), LRRK2 and ATP13A2 Many pathogenic mutations of PARK2, which encodes the ubiquitin E3 ligase parkin, result in loss of function, leading to accumulation of parkin substrates and consequently contributing to dopaminergic cell death...
August 2016: Open Biology
https://www.readbyqxmd.com/read/27514753/tetramethylpyrazine-ameliorates-rotenone-induced-parkinson-s-disease-in-rats-involvement-of-its-anti-inflammatory-and-anti-apoptotic-actions
#19
Haidy E Michel, Mariane G Tadros, Ahmed Esmat, Amani E Khalifa, Ahmed M Abdel-Tawab
Parkinson's disease (PD) is a slowly progressive neurodegenerative movement disorder. Apoptosis, neuroinflammation, and oxidative stress are the current hypothesized mechanisms for PD pathogenesis. Tetramethylpyrazine (TMP), the major bioactive component of Ligusticum wallichii Franchat (ChuanXiong), Family Apiaceae, reportedly has anti-apoptotic, anti-inflammatory and antioxidant effects. This study investigated the role of 'TMP' in preventing rotenone-induced neurobiological and behavioral sequelae. A preliminary dose-response study was conducted where rats received TMP (10, 20, and 40 mg/kg, i...
August 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27509531/dj-1-park7-sensitive-na-h-exchanger-1-nhe1-in-cd4-t-cells
#20
Yuetao Zhou, Xiaolong Shi, Hong Chen, Shaqiu Zhang, Madhuri S Salker, Andreas F Mack, Michael Föller, Tak W Mak, Yogesh Singh, Florian Lang
DJ-1/Park7 is a redox-sensitive chaperone protein counteracting oxidation and presumably contributing to the control of oxidative stress responses and thus inflammation. DJ-1 gene deletion exacerbates the progression of Parkinson's disease presumably by augmenting oxidative stress. Formation of reactive oxygen species (ROS) is paralleled by activation of the Na(+) /H(+) exchanger 1 (NHE1). ROS formation in CD4(+) T cells plays a decisive role in regulating inflammatory responses. In the present study we explored whether DJ-1 is expressed in CD4(+) T cells and affects ROS production as well as NHE1 in those cells...
August 10, 2016: Journal of Cellular Physiology
keyword
keyword
59782
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"