Agathe Quesnel, Leya Danielle Martin, Chaimaa Tarzi, Vasileios P Lenis, Nathan Coles, Meez Islam, Claudio Angione, Tiago F Outeiro, Ahmad A Khundakar, Panagiota S Filippou
BACKGROUND: Melanoma, the most lethal skin cancer type, occurs more frequently in Parkinson's disease (PD), and PD is more frequent in melanoma patients, suggesting disease mechanisms overlap. α-synuclein, a protein that accumulates in PD brain, and the oncogene DJ-1, which is associated with PD autosomal recessive forms, are both elevated in melanoma cells. Whether this indicates melanoma progression or constitutes a protective response remains unclear. We hereby investigated the molecular mechanisms through which α-synuclein and DJ-1 interact, suggesting novel biomarkers and targets in melanoma...
January 8, 2024: Cancer Medicine