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https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#1
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471559/-suturing-an-acute-acl-lesion-with-dynamic-intraligamentary-stabilisation
#2
Christoph Ihle, H Nakayama, Christoph Gonser, Ulrich Stöckle, Stefan Döbele, Steffen Schröter, Marc-Daniel Ahrend, Atesch Ateschrang
BACKGROUND: The established surgical technique for lesion of the anterior cruciate ligament (ACL) is reconstruction with an autologous tendon. However, patients after ACL-replacement have increased osteoarthritis rates. Possible explanations are persistent knee instability and the loss of the ACL's proprioceptive function. Therefore, surgeons have developed an alternative treatment to preserve the ACL by readapting femoral ACL lesions by temporary protective dynamic intraligamentary stabilisation (DIS)...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471410/risk-factors-associated-with-sustaining-a-sport-related-concussion-an-initial-synthesis-study-of-12-320-student-athletes
#3
Benjamin L Brett, Andrew W Kuhn, Aaron M Yengo-Kahn, Gary S Solomon, Scott L Zuckerman
Objective: The empirical identification of risk factors associated with sport-related concussion (SRC) may improve the management of student-athletes. The current study attempted to identify and quantify bio-cognitive risk factors associated with sustaining a SRC. Methods: Cross-sectional ambispective study; level of evidence, 3. Neurocognitive testing of 12,320 middle school, high school and collegiate athletes was completed at preseason baseline and post-SRC. Univariate and multivariable logistic regressions were used to determine which pre-injury variables accurately predicted the occurrence of SRC...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29471245/intraperitoneal-administration-of-mesenchymal-stem-cells-ameliorates-acute-dextran-sulfate-sodium-induced-colitis-by-suppressing-dendritic-cells
#4
Aleksandar Nikolic, Bojana Simovic Markovic, Marina Gazdic, C Randall Harrell, Crissy Fellabaum, Nemanja Jovicic, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L Lukic, Miodrag Stojkovic, Vladislav Volarevic
Dendritic cells (DCs) have important pathogenic role in the induction and progression of ulcerative colitis (UC), but their role in mesenchymal stem cells (MSCs)-mediated suppression of colon injury and inflammation is not revealed. By using dextran sodium sulfate (DSS)-induced colitis, a well-established murine model of UC, we examined effects of MSCs on phenotype and function of colon infiltrating DCs. Clinical, histological, immunophenotypic analysis and passive transfer of MSCs-primed DCs were used to evaluate capacity of MSC to suppress inflammatory phenotype of DCs in vivo...
February 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29471160/persistent-first-intersegmental-artery-pfia-visualized-by-three-dimensional-computed-tomography-angiography-in-chinese-population
#5
Haocong Zhang, Wei Chai, Shuang Wang, Yan Wang, Hongwei Li
BACKGROUND: Persistent first intersegmental artery (PFIA) is one of the most frequently vertebral artery (VA) variations. The presence of PFIA obviously increases the complexity and difficulty of vertebral lesion treatment. Thus, preoperative detection of PFIA is necessary to increase the successful rate of surgeries. We attempted to evaluate the utility value of three-dimension (3D) computed tomography angiography (CTA) for detecting PFIA in the north Chinese population. MATERIALS AND METHODS: Consecutive patients subjected to CTA between June 2012 and March 2014 were recruited from 5 clinical centers in the north of China...
February 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29471085/houttuynia-cordata-polysaccharides-ameliorate-pneumonia-severity-and-intestinal-injury-in-mice-with-influenza-virus-infection
#6
Haiyan Zhu, Xiaoxiao Lu, Lijun Ling, Hong Li, Yingye Ou, Xunlong Shi, Yan Lu, Yunyi Zhang, Daofeng Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Hottuynia cordata is an important traditional Chinese medicine for the treatment of respiratory diseases including bacterial and viral infections. Polysaccharides isolated from Houttuynia cordata (HCP), as its main ingredients, have been demonstrated to ameliorate the LPS-induced acute lung injury in mice. The study aimed to determine the protective effects of HCP on multiple organ injury in influenza A virus (IAV) H1N1 infected mice and its primary mechanisms in anti-inflammation and immune regulation...
February 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29470650/management-of-knee-dislocation-prior-to-ligament-reconstruction-what-is-the-current-evidence-update-of-a-universal-treatment-algorithm
#7
REVIEW
Alexander Maslaris, Olaf Brinkmann, Matthias Bungartz, Christian Krettek, Michael Jagodzinski, Emmanouil Liodakis
Traumatic knee dislocation is a rare but potentially limb-threatening injury. Thus proper initial diagnosis and treatment up to final ligament reconstruction are extremely important and a precondition to successful outcomes. Reports suggest that evidence-based systematic approaches lead to better results. Because of the complexity of this injury and the inhomogeneity of related literature, there are still various controversies and knowledge gaps regarding decision-making and step-sequencing in the treatment of acute multi-ligament knee injuries and knee dislocations...
February 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29470637/a-higher-association-of-medial-collateral-ligament-injury-of-the-knee-in-pronation-injuries-of-the-ankle
#8
Kyu-Tae Hwang, Il-Hoon Sung, Jung-Hwan Choi, Jin Kyu Lee
INTRODUCTION: To evaluate the prevalence of medial collateral ligament (MCL) injury of the knee among ankle-fracture patients and to determine the risk factors associated with MCL injury in this patient group. MATERIALS AND METHODS: 303 patients (303 affected ankles) who underwent surgical treatment for an ankle fracture were assessed. Supination versus pronation injury, Danis-Weber classification, age, sex, body mass index (BMI), limb dominance, and mechanism of injury were reviewed to identify factors related to MCL injury...
February 22, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29470598/heterotopic-ossification-around-the-knee-after-tibial-nailing-and-ipsilateral-antegrade-and-retrograde-femoral-nailing-in-the-treatment-of-floating-knee-injuries
#9
William T Kent, Trevor J Shelton, Jonathan Eastman
PURPOSE: Floating knee injuries are relatively uncommon injuries. We report the prevalence, location, and severity of heterotopic ossification (HO) around the knee in patients treated with antegrade tibial intramedullary nailing and ipsilateral antegrade versus retrograde femoral intramedullary nailing as well as how the severity of HO around the knee affects knee range of motion (ROM). METHODS: From 2004 to 2014, 26 floating knee injuries were included. Radiographs were reviewed to determine presence, location, and severity of HO...
February 22, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29470563/nonsurgical-treatment-for-posttraumatic-complete-facial-nerve-paralysis
#10
Alok Thakar, Madan P Gupta, Achal Srivastava, Deepak Agrawal, Atin Kumar
Importance: Current recommendations envisage early surgical exploration for complete facial nerve paralysis associated with temporal bone fracture and unfavorable electrophysiologic features (response to electroneuronography, <5%). However, the evidence base for such a practice is weak, with the potential for spontaneous improvement being unknown, and the expected results from alternative nonsurgical treatment also undefined. Objective: To document the results of nonsurgical treatment for posttraumatic complete facial paralysis with undisplaced temporal bone fracture and unfavorable electrophysiologic features...
February 22, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29470527/value-of-diagnostic-and-therapeutic-laparoscopy-for-patients-with-blunt-abdominal-trauma-a-10-year-medical-center-experience
#11
Heng-Fu Lin, Ying-Da Chen, Shyr-Chyr Chen
Laparoscopy has been used for the diagnosis and treatment for hemodynamically stable patients with penetrating abdominal trauma. This study evaluated whether diagnostic and therapeutic laparoscopy can be used as effectively in select patients with blunt abdominal trauma. All hemodynamically stable patients undergoing operations for blunt abdominal trauma over a 10-year period (2006-2015) at a tertiary medical center were included. Patients undergoing laparotomy were categorized as group A. Patients who underwent laparoscopy were categorized as group B...
2018: PloS One
https://www.readbyqxmd.com/read/29470503/sevoflurane-posttreatment-prevents-oxidative-and-inflammatory-injury-in-ventilator-induced-lung-injury
#12
Julie Wagner, Karl M Strosing, Sashko G Spassov, Ziwei Lin, Helen Engelstaedter, Sabine Tacke, Alexander Hoetzel, Simone Faller
Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species, release of pro-inflammatory cytokines, and transmigration as well as activation of neutrophil cells, are needed to improve the clinical outcome of ventilated patients. Though the inhaled anesthetic sevoflurane is known to exert organ-protective effects, little is known about the potential of sevoflurane therapy in ventilator-induced lung injury...
2018: PloS One
https://www.readbyqxmd.com/read/29470486/lassa-fever-induced-sensorineural-hearing-loss-a-neglected-public-health-and-social-burden
#13
REVIEW
Elizabeth J Mateer, Cheng Huang, Nathan Y Shehu, Slobodan Paessler
Although an association between Lassa fever (LF) and sudden-onset sensorineural hearing loss (SNHL) was confirmed clinically in 1990, the prevalence of LF-induced SNHL in endemic countries is still underestimated. LF, a viral hemorrhagic fever disease caused by Lassa virus (LASV), is endemic in West Africa, causing an estimated 500,000 cases and 5,000 deaths per year. Sudden-onset SNHL, one complication of LF, occurs in approximately one-third of survivors and constitutes a neglected public health and social burden...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29470292/rectal-picking-masquerading-as-inflammatory-bowel-disease-in-prader-willi-syndrome
#14
Parisa Salehi, Dale Lee, Lusine Ambartsumyan, Natalie Sikka, Ann O Scheimann
Prader-Willi syndrome (PWS) is a genetic syndrome in which individuals have multisystem medical challenges. Gastroenterological difficulties in the syndrome include decreased vomiting, constipation, delayed gastric emptying, delayed colonic transit, dysphagia, increased choking, and increased risk of gastric dilation and rupture. In addition, self-injurious behavior such as rectal picking may be present and severe enough to lead to rectal ulceration and bleeding. Many patients have extensive gastroenterological workup and treatment before their ultimate diagnosis of severe rectal picking...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470190/blood-transfusion-management-in-the-severely-bleeding-military-patient
#15
Jennifer M Gurney, Philip C Spinella
PURPOSE OF REVIEW: Hemorrhage remains the primary cause of preventable death on the battlefield and in civilian trauma. Hemorrhage control is multifactorial and starts with point-of-injury care. Surgical hemorrhage control and time from injury to surgery is paramount; however, interventions in the prehospital environment and perioperative period affect outcomes. The purpose of this review is to understand concepts and strategies for successful management of the bleeding military patient...
February 22, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29469974/assessment-of-canine-pancreas-specific-lipase-and-outcomes-in-dogs-with-hemodialysis-dependent-acute-kidney-injury
#16
K Takada, C A Palm, S E Epstein, L D Cowgill
BACKGROUND: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. HYPOTHESIS/OBJECTIVES: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29469803/use-of-the-hemicap-partial-hip-resurfacing-technique-for-traumatic-femoral-head-osteochondral-defects-following-obturator-hip-dislocations
#17
Varun Arora, Pierre Navarre, Mathias Russ, Max Esser
Fracture of the femoral head (OTA 31-C1.3) following anterior obturator dislocations are a challenging problem as the fractures are often communited, impacted and with loose osteochondral fragments, making surgical fixation difficult. This can result in residual articular defects if the fragments cannot be internally fixed and need be excised, predisposing to secondary osteoarthritis. Treatment options for these defects are limited, have variable results and with limited literature to guide us on outcomes due to the rarity of these injuries...
2018: SICOT-J
https://www.readbyqxmd.com/read/29469695/cutaneous-balamuthia-mandrillaris-infection-as-a-precursor-to-balamuthia-amoebic-encephalitis-bae-in-a-healthy-84-year-old-californian
#18
Larisa M Lehmer, Gabriel E Ulibarri, Bruce D Ragsdale, James Kunkle
Soil and freshwater-dwelling amoebae may opportunistically infect the skin and evoke a granulomatous dermatitis that camouflages their underlying morphology. Amoebic infestations are incredibly rare in the U.S., predominantly occurring in the young, elderly, and immunocompromised. Sadly, because diagnosis is difficult and unsuspected, most cases are diagnosed at autopsy. The following case is of a healthy 84-year-old man with a non-healing nodulo-ulcerative cutaneous lesion on his left forearm that appeared following a gardening injury...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469667/10-year-outcome-of-suicidal-behavior-in-borderline-personality-disorder
#19
Paul H Soloff, Laurel Chiappetta
Prospective predictors of suicide attempts were assessed in 118 subjects with borderline personality disorder (BPD) after 10 or more years of follow-up. Mean (SD) time to follow-up was 14.4 (4.7) years. Subjects were predominately female (78.8%), Caucasian (81.4%), and of lower socioeconomic status. Initial recruitment was evenly balanced between inpatient, outpatient, and non-patient (community) sources. In the 10-year interval, 55 subjects (46.6%) attempted suicide. Compared to baseline, suicidal ideation, number of attempts, and non-suicidal self-injury diminished markedly...
February 22, 2018: Journal of Personality Disorders
https://www.readbyqxmd.com/read/29469658/evolving-treatment-patterns-of-nfl-players-by-orthopaedic-team-physicians-over-the-past-decade-2008-2016
#20
John B Schrock, Trevor J Carver, Matthew J Kraeutler, Eric C McCarty
BACKGROUND: Previous studies have analyzed the treatment patterns used to manage injuries in National Football League (NFL) players. HYPOTHESIS: Treatment patterns for injuries in NFL players will have changed over the study period. STUDY DESIGN: Descriptive epidemiology study. LEVEL OF EVIDENCE: Level 5. METHODS: The head orthopaedic team physicians for all 32 NFL teams were asked to complete a survey containing questions regarding experience as team physician, medical coverage of the team, and treatment preferences for some of the most common injuries occurring in football players...
February 1, 2018: Sports Health
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