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Lymphnode biopsy

G Caocci, M Greco, D Fanni, G Senes, R Littera, S Lai, P Risso, C Carcassi, G Faa, G La Nasa
Non-classical human leucocyte antigen (HLA)-G class I molecules have an important role in tumor immune escape mechanisms. We investigated HLA-G expression in lymphonode biopsies taken from 8 controls and 20 patients with advanced-stage classical Hodgkin lymphoma (cHL), in relationship to clinical outcomes and the HLA-G 14-basepair (14-bp) deletion-insertion (del-ins) polymorphism. Lymphnode tissue sections were stained using a specific murine monoclonal HLA-G antibody. HLA-G protein expression was higher in cHL patients than controls...
2016: European Journal of Histochemistry: EJH
Yi-Qun Huang, Rui-Ji Zheng, Rong-Juan Wu, Xu-Dong Ma
OBJECTIVE: To summarize the clinical features and therapy experience of a case of CD5 positive diffuse large B cell lymphoma (CD5+ DLBCL) with autoimmune hemolytic anemia (AIHA). METHODS: A 49-years old patient was investigated. The routine blood examination, bone marrow smear, Coombs test, serological test, chest CT, abdominal MR and immunochemistry etc were performed for this patient; and therapeutic effects of the chemotherapy regimen consisting of rituximab plus autologous hematopoietic stem cell transplantation (auto-HSCT) were observed...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Yazan Abdeen, Sawsan Amireh, Alpa Patel, Moh'd Al-Halawani, Hamid Shaaban, Richard Miller
CONTEXT: According to the recent World Health Organization reports, lung cancer has become the most common type of malignancy and the leading cause of death from cancer. Lung cancer frequently metastasizes to hilar lymphnodes, brain, adrenal glands, bone, but rarely to skin. CASE REPORT: We report a case of a 72-year-old male with a past medical history of pulmonary fibrosis and no prior history of smoking who presented to the emergency room for progressive dyspnea over three weeks...
May 2016: North American Journal of Medical Sciences
Naveen Padmanabhan, Muhamed Faizal Ayub, Khadher Hussain, Ann Kurien, Selvi Radhakrishna
Current guidelines recommend completion axillary lymphnode dissection (ALND) when sentinel lymphnode (SLN) contains metastatic tumor deposit. In consequent ALND sentinel node is the only node involved by tumor in 40-70 % of cases. Recent studies demonstrate the oncologic safety of omitting completion ALND in low risk patients. Several nomograms (MSKCC, Stanford, MD Anderson score, Tenon score) had been developed in predicting the likelihood of additional nodes metastatic involvement. We evaluated accuracy of MSKCC nomogram and other clinicopathologic variables associated with additional lymph node metastasis in our patients...
December 2015: Indian Journal of Surgical Oncology
Harijono Achmad, Rofika Hanifa
We report a patient with supraclavicular lymph node metastasis from an undetectable adenocarcinoma of the transverse colon, who presented with cough and was diagnosed with typhoid fever, bronchitis as well as liver metastasis. There were an abdominal fullness, weight loss, constipation, pencil-like stool with mucous and blood, low-grade fever, bone ache, and tea-color urine. The first colonoscopy revealed lymphocytic ileitis and microscopic findings also showed lymphocytic ileitis. Abdominal USG and CT revealed liver metastasis of unknown origin...
October 2015: Acta Medica Indonesiana
Yan-Ping Li, Zhi-Hua Zhang, Feng-Ting Zhao
OBJECTIVE: To explore the value of multiparameter flow cytometry in diagnosis of non-Hodgkin's lymphoma (NHL). METHODS: Twenty patients with NHL admitted in Traditional Chinese Medicine Hospital of Zhengzhou from January 2009 to August 2014 years were enrolled into this study, among them 13 cases received lymnode puncture, 2 cases were given bone marrow aspiration, 2 cases received peripheral blood examination, 3 cases suffered lymphnode biopsy. RESULTS: After FCM immune typing and cytological smear, 6 cases was confirmed to be B-SLL, 1 case was B-NHL, 1 case was FL, 5 cases was DLBCL, 2 cases was T-NHL, 3 cases was T-LBL, 1 case was NK/T-NHL, 1 case was PTun...
February 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Matthias Dürst, Heike Hoyer, Christoph Altgassen, Christiane Greinke, Norman Häfner, Alba Fishta, Mieczyslaw Gajda, Ute Mahnert, Peter Hillemanns, Thomas Dimpfl, Miriam Lenhard, K Ulrich Petry, Ingo B Runnebaum, Achim Schneider
Up to 15% of patients with cervical cancer and pN0-status develop recurrent-disease. This may be due to occult metastatic spread of tumor cells. We evaluated the use of human-papillomavirus-(HPV)-mRNA as a molecular marker for disseminated tumor cells to predict the risk of recurrence. For this prospective, multi-center prognostic study, 189 patients free of lymphnode metastases by conventional histopathology could be analyzed. All patients underwent complete lymphadenectomy. Of each sentinel node (SLN) a biopsy was taken for the detection of HPV-E6-E7-mRNA...
September 8, 2015: Oncotarget
Syed Ali Baqher Hussaini, Sainath K Andola, Anita Mahanta
CONTEXT: Lymph nodes are the most common site of metastatic malignancy, and sometimes constitute the first clinical manifestation of the disease. Metastases are tumour implants discontinuous with the primary tumour. The characterization of a neoplasm as primary or metastatic has always troubled surgical pathologists. AIM: To study distribution of lymph node metastasis in North Karnataka region based on age, sex, location and morphological features, and to explore the utility of special stains and immunohistochemistry (IHC) in its diagnosis...
March 2015: Journal of Clinical and Diagnostic Research: JCDR
Hanghang Wang, Karissa Heck, Scott K Pruitt, Terence Z Wong, Randall P Scheri, Gregory S Georgiade, Ikwunze Ichite, E Shelley Hwang
BACKGROUND: Despite universal adoption of sentinel lymph node biopsy (SLNB) for breast cancer, there remains no standardized protocol for preoperative lymphoscintographic assessment of sentinel nodes. Both immediate and delayed lymphoscintigraphy are currently utilized, although it is unclear how delayed imaging impacts SLN identification. METHODS: Among patients diagnosed with breast cancer who underwent SLNB at Duke from 2011 to 2012, two protocols for preoperative lymphoscintigraphy were used: protocol A included both immediate and delayed lymphoscintigraphy (n = 152), while protocol B involved immediate lymphoscintigraphy only (n = 103)...
June 2015: Journal of Surgical Oncology
Andrea Morlino, Giuseppe La Torre, Giulia Vitagliano, Aldo Cammarota
AIM: The aim of this study was to report a case concerning diagnostic and management of Anorectal melanoma. MATERIAL: A 71 years old white man presented in our Institute with anal pain, tenesmus, blooding rectal during the last five months. The ano-rectal examination showed a brownish painful mass in the anal canal. The colonscopy and endoscopy showed a big stenotic mass from anal canal to medium rectum with a diameter of approximately 90 mm. RESULTS: Biopsy of the rectal mass was performed and the histopatological examination showed malignant ephitelioid cells, pigmented melanoma...
2015: Annali Italiani di Chirurgia
L Rebegea, D Firescu, M Dumitru, R Anghel
BACKGROUND: The arm lymphedema is reported as being the most frequent late reaction and complication that influences breast cancer patients'€™ quality of life after lymph node dissection and radiotherapy. The aim of the study is to identify the risk factors in arm lymphedema occurrence in breast cancer patients who performed radical conservatory surgery, chemotherapy and radiotherapy. MATERIAL AND METHODS: We analysed 305 breast cancer patients who underwent treatment in the "Sf...
January 2015: Chirurgia
M Gherghe, C Bordea, Al Blidaru
BACKGROUND: Identification and biopsy of the sentinel lymph node (SLN) in early-stage breast cancer (T1-T2N0) has become the standard method in the surgical treatment of the axilla, due to its accuracy in the evaluation of axillary lymph node status,thus avoiding extensive axillary lymph node dissection inpatients with negative SLN. The aim of our study is to highlight the role of 99mTc-nanocolloid lymphoscintigraphy in the preoperative lymphatic mapping, especially for SLN localizations outside the axilla, as well as the benefits of this technique in the accurate staging of breast cancer...
January 2015: Chirurgia
S Khatoon, S W Kolte, N V Kurkure, N A Chopde, A Jahan
Tropical bovine theileriosis, a tick borne disease, caused by, Theileria annulata with marked clinical signs of pyrexia (102-105 °F), enlargement of lymphnodes etc., causes heavy economic losses in terms of high mortality and morbidity rates. Diagnosis of theileriosis is mainly based on clinical symptoms and microscopic examination of stained blood smears and lymph node biopsy smears but limitations of these methods against Theileria sp. limits the specificity. Hence, to overcome the limitations, the present study reports the detection of T...
March 2015: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Xinmeng Qi, Dan Yu, Xue Zhao, Chunshun Jin, Changling Sun, Xueshibojie Liu, Jinzhang Cheng, Dejun Zhang
Endoscopy is essential for the diagnosis and treatment of cancers derived from the larynx. However, a laryngoscope with conventional white light (CWL) has technical limitations in detecting small or superficial lesions on the mucosa. Narrow band imaging especially combined with magnifying endoscopy (ME) is useful for the detection of superficial squamous cell carcinoma (SCC) within the oropharynx, hypopharynx, and oral cavity. A total of 3675 patients who have come to the outpatient clinic and complained of inspiratory stridor, dyspnea, phonation problems or foreign body sensation, were enrolled in this study...
2014: International Journal of Clinical and Experimental Medicine
Yasushi Yumura, Yuusuke Hattori, Jun Kasuga, Daiji Takamoto, Kazumi Noguchi, Takeshi Sasaki
We investigated the incidence of inguinal lymph node metastasis in 66 penile cancer patients with no palpable or visibly enlarged inguinal lymph nodes (cN0). Median follow up interval was 35. 7 months. During follow up, 14 patients (21.2%) had inguinal lymph node metastasis and 6 patients died of cancer. Five-year disease-free survival was 77.3%. Univariate analysis demonstrated that local tumor staging (T), differentiation, lymphovascular invasion (LVI), and tumor infiltration pattern (INF, Yamamoto-Kohama grading system) were associated with the incidence of inguinal lymphnode metastasis...
October 2014: Hinyokika Kiyo. Acta Urologica Japonica
Naz Chaudary, Karolina Jaluba, Melania Pintilie, Richard P Hill
Standard treatment for women who are diagnosed with stage IIB through IVA cervical cancer consists of cisplatin-based chemotherapy and radiation. Current options for patients with recurrent and metastatic disease are limited, and their median overall survival is <12 months. To date, biologic therapy has had little impact on survival, so identification of potential new targets is urgently required to develop novel therapeutic strategies. Developing relevant animal models for human cervix cancer is important to further enhance our understanding of the characteristics of these tumors and for identification and assessment of novel therapies...
2015: Methods in Molecular Biology
Deepa Kuchelan, Sameh Aziz
Cancer Case Report Posters ISESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Castleman's Disease (CD) is a rare lymphoproliferative disorder first reported by Castleman et al in 1956. Two forms have been described; localized unicentric disease and rare multicentric disease with involvement of multiple sites. Multicentric CD (MCD) is more commonly seen in immunosuppressed patients, especially in HIV and HHV 8 positive patients. Here we discuss the diagnostic challenge of a patient presenting with a large anterior mediastinal mass and rare HIV and HHV 8 negative multicentric CD...
October 1, 2014: Chest
V Mukta, Chandragiri Susmitha, Rakhee Kar, Debdatta Basu, A K Das
Castleman's disease is a nonneoplastic adenopathy, also known as angiofollicular or giant lymphnode hyperplasia. Its multicentric form presents with wide spread lymphadenopathy and systemic symptoms. POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) is observed in 11-30 % of the patients with Castleman's disease (Dispenzieri et al., Blood 101:2496-2506, 2003). Tuberculosis and lymphoma are the common diagnosis in patients with clinical features of weight loss, lymphadenopathy, hepatosplenomegaly and lymphocyte predominant ascites...
September 2014: Indian Journal of Hematology & Blood Transfusion
Rodger Scott Stitt, Robert Greenwood, Jeffrey Laczek
A 42 year-old African-American woman was admitted for severe acute right upper quadrant pain. Her liver function tests showed a cholestatic pattern of hepatitis. She had no known history of liver disease or sarcoidosis. Imaging of her liver and biliary tree did not reveal any apparent cause for her right upper quadrant pain. A liver biopsy was performed which showed granulomatous disease. This prompted a CT chest that showed mediastinal lymphadenopathy. Biopsy of the mediastinal lymphnode revealed non-caseating granulomas...
2014: BMJ Case Reports
V Kaikaris, D Samsanavicius, K Maslauskas, R Rimdeika, J Ulrich, G Kuprionis, A Mickevicius, J Pundzius
UNLABELLED: The aim of our study was to compare the number of detected sentinel lymph nodes and the incidence of micrometastases between two groups of patients with cutaneous melanoma. METHODS: 100 patients were divided in to two groups: group V and group D. Group V patients (50) with melanoma underwent a single-stage surgery--radical excision of the tumour with sentinel lymph node biopsy (study group "V"). Group D patients (50) with melanoma underwent two-stage surgery; initially primary diagnostic excision of the tumour (0...
May 2014: Acta Chirurgica Belgica
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