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https://www.readbyqxmd.com/read/27878132/ruptured-cystic-mesothelioma-diagnosed-after-blunt-trauma-case-report-and-literature-review
#1
Francisco Igor B Macedo, Alice J Race, Laszlo M Hoesel
The majority of blunt trauma is secondary to motor vehicle crashes,especially in those wearing seatbelts or sitting in the front or passenger seat location.Hollow viscus gastrointestinal injuries occur more frequently in small bowel, followed by colorectal, duodenum, stomach and appendix. A 25-year-old male presents after being involved in a motor vehicle accident. Initialworkup was significant for moderate amount of pelvic free fluid and curvilinear,cysticlike structures in the pelvis. He subsequently developed peritonitis and underwentdiagnostic laparoscopy, which revealed multiple cystic nodules arising from theperitoneum...
October 2016: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/27858093/targeted-intraoperative-radiotherapy-tumour-bed-boost-during-breast-conserving-surgery-after-neoadjuvant-chemotherapy
#2
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Cornelia Liedtke, Max Bulsara, Jayant S Vaidya
INTRODUCTION: The use of targeted intraoperative radiotherapy (TARGIT-IORT) as a tumour bed boost during breast-conserving surgery (BCS) for breast cancer has been reported since 1998. We present its use in patients undergoing breast conservation following neoadjuvant therapy (NACT). METHOD: In this retrospective study involving 116 patients after NACT we compared outcomes of 61 patients who received a tumour bed boost with IORT during lumpectomy versus 55 patients treated in the previous 13 months with external (EBRT) boost...
November 17, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27827911/changes-in-body-composition-in-the-two-years-after-initiation-of-haemodialysis-a-retrospective-cohort-study
#3
David Keane, Claire Gardiner, Elizabeth Lindley, Simon Lines, Graham Woodrow, Mark Wright
Malnutrition is common in haemodialysis (HD) and is linked to poor outcomes. This study aimed to describe changes in body composition after the initiation of HD and investigate whether any routinely collected parameters were associated with these changes. The study cohort came from the HD population of a single centre between 2009 and 2014. Body composition measurements were obtained from a database of bioimpedance results using the Body Composition Monitor (BCM), while demographics and laboratory values came from the renal unit database...
November 4, 2016: Nutrients
https://www.readbyqxmd.com/read/27769238/bcm-toolkit-for-bayesian-analysis-of-computational-models-using-samplers
#4
Bram Thijssen, Tjeerd M H Dijkstra, Tom Heskes, Lodewyk F A Wessels
BACKGROUND: Computational models in biology are characterized by a large degree of uncertainty. This uncertainty can be analyzed with Bayesian statistics, however, the sampling algorithms that are frequently used for calculating Bayesian statistical estimates are computationally demanding, and each algorithm has unique advantages and disadvantages. It is typically unclear, before starting an analysis, which algorithm will perform well on a given computational model. RESULTS: We present BCM, a toolkit for the Bayesian analysis of Computational Models using samplers...
October 21, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27680716/clinical-evaluation-of-glutathione-concentrations-after-consumption-of-milk-containing-different-subtypes-of-%C3%AE-casein-results-from-a-randomized-cross-over-clinical-trial
#5
Richard Deth, Andrew Clarke, Jiayi Ni, Malav Trivedi
: This study reports the plasma glutathione concentrations in a double-blind, randomized, controlled, 2 × 2 cross-over study in which healthy participants consumed conventional milk (2 × 250 mL per day) containing both A1 and A2 types of β-casein, or milk containing only A2 type β-casein. Beta-casomorphin-7 (BCM-7), a peptide uniquely derived from the A1 type of β-casein, was previously reported to downregulate glutathione expression in human gut epithelial and neuronal cell lines by limiting cysteine uptake...
September 29, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27666944/validating-body-fat-assessment-by-bioelectric-impedance-spectroscopy-in-taiwanese-hemodialysis-patients
#6
Paik Seong Lim, Chang Hsu Chen, Fansan Zhu, Peter Kotanko, Yachung Jeng, Chun Yu Hu, Li Shu Chiu, Hui-Chen Chang
OBJECTIVE: Obesity is becoming increasingly common in hemodialysis (HD) patients and is associated with inflammation and increased mortality. The primary aim of the present study was to evaluate the accuracy and variability of the bioimpedance device in measuring body fat in Taiwanese dialysis patients. DESIGN: Cross-sectional study. SUBJECTS: One hundred twenty-two adult patients receiving HD in a single hospital in Taiwan. SETTING: We compared the results of fat mass (FM) measured by dual-energy x-ray absorptiometry (DEXA) and bioelectrical impedance spectroscopy device (Body composition monitor, BCM)...
September 22, 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/27648408/is-overhydration-in-peritoneal-dialysis-patients-associated-with-cardiac-mortality-that-might-be-reversible
#7
Elizabeth Oei, Klara Paudel, Annemarie Visser, Hazel Finney, Stanley L Fan
AIM: To study the relationship between overhydration (OH) in peritoneal dialysis (PD) patients and cardiac mortality. METHODS: OH, as measured by body composition monitor (BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T (cTnT) levels...
September 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27647501/a-concept-mapping-study-on-organic-food-consumers-in-shanghai-china
#8
Huliyeti Hasimu, Sergio Marchesini, Maurizio Canavari
Despite some similarities with developed countries, the growth of organic market in China seems to follow a different path. Thus, important questions are how Chinese urban consumers perceive organic food, and what are the main concepts associated to the organic attribute. We aimed at representing in graphic form the network of mental associations with the organic concept. We used an adapted version of the "Brand concept mapping" method to acquire, process, and draw individual concept networks perceived by 50 organic food consumers in Shanghai...
September 16, 2016: Appetite
https://www.readbyqxmd.com/read/27640675/dna-barcoding-reveal-patterns-of-species-diversity-among-northwestern-pacific-molluscs
#9
Shao'e Sun, Qi Li, Lingfeng Kong, Hong Yu, Xiaodong Zheng, Ruihai Yu, Lina Dai, Yan Sun, Jun Chen, Jun Liu, Lehai Ni, Yanwei Feng, Zhenzhen Yu, Shanmei Zou, Jiping Lin
This study represents the first comprehensive molecular assessment of northwestern Pacific molluscs. In total, 2801 DNA barcodes belonging to 569 species from China, Japan and Korea were analyzed. An overlap between intra- and interspecific genetic distances was present in 71 species. We tested the efficacy of this library by simulating a sequence-based specimen identification scenario using Best Match (BM), Best Close Match (BCM) and All Species Barcode (ASB) criteria with three threshold values. BM approach returned 89...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27620902/application-of-bioimpedance-spectroscopy-in-asian-dialysis-patients-abisad-iii-a-randomized-controlled-trial-for-clinical-outcomes
#10
Chen Huan-Sheng, Chang Yeong-Chang, Hsieh Ming-Hsing, Tseng Fan-Lieh, Lin Chu-Cheng, Wu Tsai-Kun, Chen Hung-Ping, Hung Sze-Hung, Chiu Hsien-Chang, Lee Chia-Chen, Hou Chun-Cheng, Cheng Chun-Ting, Liou Hung-Hsiang, Lin Chun-Ju, Lim Paik-Seong
PURPOSE: Fluid management with body composition monitor based on bioimpedance spectroscopy (BCM-BIS) has been found to be beneficial for dialysis patients. We conducted a study to provide an algorithm for the determination of post-dialysis target weight (PDTW) and to evaluate whether this approach could improve clinical outcomes compared to patients who had PDTW decided clinically. METHODS: Two hundred and ninety-eight dialysis patients participated in this 1-year randomized controlled trial...
November 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27574316/inferring-brain-computational-mechanisms-with-models-of-activity-measurements
#11
Nikolaus Kriegeskorte, Jörn Diedrichsen
High-resolution functional imaging is providing increasingly rich measurements of brain activity in animals and humans. A major challenge is to leverage such data to gain insight into the brain's computational mechanisms. The first step is to define candidate brain-computational models (BCMs) that can perform the behavioural task in question. We would then like to infer which of the candidate BCMs best accounts for measured brain-activity data. Here we describe a method that complements each BCM by a measurement model (MM), which simulates the way the brain-activity measurements reflect neuronal activity (e...
October 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27537699/improved-quantification-of-the-beta-cell-mass-after-pancreas-visualization-with-99m-tc-demobesin-4-and-beta-cell-imaging-with-111-in-exendin-3-in-rodents
#12
Inge van der Kroon, Lieke Joosten, Berthold A Nock, Theodosia Maina, Otto C Boerman, Maarten Brom, Martin Gotthardt
OBJECTIVE: Accurate assessment of the (111)In-exendin-3 uptake within the pancreas requires exact delineation of the pancreas, which is highly challenging by MRI and CT in rodents. In this study, the pancreatic tracer (99m)Tc-demobesin-4 was evaluated for accurate delineation of the pancreas to be able to accurately quantify (111)In-exendin-3 uptake within the pancreas. METHODS: Healthy and alloxan-induced diabetic Brown Norway rats were injected with the pancreatic tracer (99m)Tc-demobesin-4 ([(99m)Tc-N4-Pro(1),Tyr(4),Nle(14)]bombesin) and the beta cell tracer (111)In-exendin-3 ([(111)In-DTPA-Lys(40)]exendin-3)...
October 3, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27535063/the-effect-of-a-drospirenone-containing-combined-oral-contraceptive-on-female-sexual-function-a-prospective-randomised-study
#13
Lina Čiaplinskienė, Birutė Žilaitienė, Rasa Verkauskienė, Rimantas Žalinkevičius, Žana Bumbulienė, Virginija Vanagienė, Johannes Bitzer
OBJECTIVES: The study investigated the effects on female sexual function of a progestogen-containing combined oral contraceptives (COCs) with an antiandrogenic profile taken in a continuous regimen. METHODS: In this prospective randomised single-institution study, 80 healthy women with a monogamous partner and an active sexual life were randomised into two groups for a period of 3 months. Women in the exposed group (n = 40) took a COCs containing 30 μg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) in a 21/7 regimen...
October 2016: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/27515331/bioabsorbable-intracoronary-matrix-for-prevention-of-ventricular-remodeling-after-myocardial-infarction
#14
Sunil V Rao, Uwe Zeymer, Pamela S Douglas, Hussein Al-Khalidi, Jennifer A White, Jingyu Liu, Howard Levy, Victor Guetta, C Michael Gibson, Jean-Francois Tanguay, Paul Vermeersch, Jérôme Roncalli, Jaroslaw D Kasprzak, Timothy D Henry, Norbert Frey, Oscar Kracoff, Jay H Traverse, Derek P Chew, Jose Lopez-Sendon, Reinilde Heyrman, Mitchell W Krucoff
BACKGROUND: Bioabsorbable cardiac matrix (BCM) is a novel device that attenuates adverse left ventricular (LV) remodeling after large myocardial infarctions in experimental models. OBJECTIVES: This study aimed to analyze whether BCM, compared with saline control, would result in less LV dilation and fewer adverse clinical events between baseline and 6 months. METHODS: In an international, randomized, double-blind, controlled trial, 303 subjects with large areas of infarction despite successful primary percutaneous coronary intervention (PCI) of ST-segment elevation myocardial infarction (STEMI) were randomized 2:1 to BCM or saline injected into the infarct-related artery 2 to 5 days after primary PCI...
August 16, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27509588/correlation-between-volume-overload-chronic-inflammation-and-left-ventricular-dysfunction-in-chronic-kidney-disease-patients
#15
Muzamil Olamide Hassan, Raquel Duarte, Therese Dix-Peek, Ahmed Vachiat, Sagren Naidoo, Caroline Dickens, Sacha Grinter, Pravin Manga, Saraladevi Naicker
BACKGROUND: Fluid overload is common in chronic kidney disease (CKD) patients, potentially driving chronic inflammation and left ventricular dysfunction. We investigated the association between volume overload, chronic inflammation, and left ventricular dysfunction across subgroups of CKD patients. METHODS: The study included 160 participants, comprising peritoneal dialysis (PD), hemodialysis (HD), stage-3 CKD patients, and age- and sex-matched controls (40 in each group)...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27496430/influence-of-body-mass-on-kidney-graft-function-in-patients-after-kidney-transplantation
#16
S Małgorzewicz, A Dębska-Slizień, B Czajka, A Owczarzak, B Rutkowski
BACKGROUND: Increasing evidence shows that body mass may play a role in complications after kidney transplantation and influence graft and patient survival. The aim of this study was to analyze the association between graft function and both the body mass and adipokines (leptin, visfatin, adiponectin) in kidney transplant recipients. METHODS: We studied 183 kidney transplant recipients from the Department of Nephrology, Transplantology and Internal Disease, Medical University of Gdansk...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27485552/stochastic-induction-of-long-term-potentiation-and-long-term-depression
#17
G Antunes, A C Roque, F M Simoes-de-Souza
Long-term depression (LTD) and long-term potentiation (LTP) of granule-Purkinje cell synapses are persistent synaptic alterations induced by high and low rises of the intracellular calcium ion concentration ([Ca(2+)]), respectively. The occurrence of LTD involves the activation of a positive feedback loop formed by protein kinase C, phospholipase A2, and the extracellular signal-regulated protein kinase pathway, and its expression comprises the reduction of the population of synaptic AMPA receptors. Recently, a stochastic computational model of these signalling processes demonstrated that, in single synapses, LTD is probabilistic and bistable...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27452637/influence-of-ruminal-methane-on-digesta-retention-and-digestive-physiology-in-non-lactating-dairy-cattle
#18
Marie T Dittmann, Kirsty J Hammond, Paul Kirton, David J Humphries, Les A Crompton, Sylvia Ortmann, Tom H Misselbrook, Karl-Heinz Südekum, Angela Schwarm, Michael Kreuzer, Christopher K Reynolds, Marcus Clauss
Enteric methane (CH4) production is a side-effect of herbivore digestion, but it is unknown whether CH4 itself influences digestive physiology. We investigated the effect of adding CH4 to, or reducing it in, the reticulorumen (RR) in a 4×4 Latin square experiment with rumen-fistulated, non-lactating cows, with four treatments: (i) control, (ii) insufflation of CH4 (iCH4), (iii) N via rumen fistula, (iv) reduction of CH4 via administration of bromochloromethane (BCM). DM intake (DMI), apparent total tract digestibility, digesta mean retention times (MRT), rumen motility and chewing activity, spot breath CH4 emission (CH4exhal, litre/kg DMI) as well as CH4 dissolved in rumen fluid (CH4RRf, µg/ml) were measured...
September 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27431628/-evolving-5-fluorouracil-therapy-to-achieve-enhanced-efficacy-past-and-current-efforts-of-researchers
#19
Yoshihiko Maehara, Eiji Oki, Hiroshi Saeki, Eriko Tokunaga, Hiroyuki Kitao, Makoto Iimori, Shinichiro Niimi, Yuki Kataoka, Yasunori Emi, Yoshihiro Kakeji, Hideo Baba, Tetsuhiko Shirasaka
5-fluorouracil(5-FU)therapy has advanced greatly over the past 50 years, achieving enhanced therapeutic effects and reduced adverse effects. By taking advantage of the metabolism of 5-FU, researchers have made efforts to develop prodrugs, combination drug products, and combination therapy regimens via biochemical modulation(BCM)with alteration of the drug metabolism. Examples include the advent of the prodrug tegafur(FT), followed by tegafur-uracil(UFT)and tegafurgimeracil- potassium oxonate(S-1)as combined products based on BCM...
July 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27430310/bone-conditioned-media-bcm-improves-osteoblast-adhesion-and-differentiation-on-collagen-barrier-membranes
#20
Masako Fujioka-Kobayashi, Jordi Caballé-Serrano, Dieter D Bosshardt, Reinhard Gruber, Daniel Buser, Richard J Miron
BACKGROUND: The use of autogenous bone chips during guided bone regeneration procedures has remained the gold standard for bone grafting due to its excellent combination of osteoconduction, osteoinduction and osteogenesis. Recent protocols established by our group have characterized specific growth factors and cytokines released from autogenous bone that have the potential to be harvested and isolated into bone conditioned media (BCM). Due to the advantageous osteo-promotive properties of BCM, the aims of the present study was to pre-coat collagen barrier membranes with BCM and investigate its effect on osteoblast adhesion, proliferation and differentiation for possible future clinical use...
2016: BMC Oral Health
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