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https://www.readbyqxmd.com/read/29345858/cardiopulmonary-fitness-is-strongly-associated-with-body-cell-mass-and-fat-free-mass
#1
Armin Köhler, Ryan King, Martin Bahls, Stefan Groß, Antje Steveling, Simone Gärtner, Sabine Schipf, Sven Gläser, Henry Völzke, Stephan B Felix, Marcello Ricardo Paulista Markus, Marcus Dörr
BACKGROUND: Peak oxygen uptake (VO2peak) is commonly indexed by total body weight (TBW) to determine cardiopulmonary fitness (CPF). This approach may lead to misinterpretation, particularly in obese subjects. We investigated the normalization of VO2peak by different body composition markers. METHODS: We analyzed combined data of 3,848 subjects (1,914 women; 49.7%), aged 20-90, from two independent cohorts of the population-based Study of Health in Pomerania (SHIP-2 and SHIP-TREND)...
January 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29341236/induced-earthquakes-from-long-term-gas-extraction-in-groningen-the-netherlands-statistical-analysis-and-prognosis-for-acceptable-risk-regulation
#2
Charles Vlek
Recently, growing earthquake activity in the northeastern Netherlands has aroused considerable concern among the 600,000 provincial inhabitants. There, at 3 km deep, the rich Groningen gas field extends over 900 km2 and still contains about 600 of the original 2,800 billion cubic meters (bcm). Particularly after 2001, earthquakes have increased in number, magnitude (M, on the logarithmic Richter scale), and damage to numerous buildings. The man-made nature of extraction-induced earthquakes challenges static notions of risk, complicates formal risk assessment, and questions familiar conceptions of acceptable risk...
January 16, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29329325/classification-of-patients-with-knee-osteoarthritis-in-clinical-phenotypes-data-from-the-osteoarthritis-initiative
#3
A Dell'Isola, M Steultjens
OBJECTIVES: The existence of phenotypes has been hypothesized to explain the large heterogeneity characterizing the knee osteoarthritis. In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). The purpose of this study was to classify a sample of individuals with knee osteoarthritis (KOA) into pre-defined groups characterized by specific variables that can be linked to different disease mechanisms, and compare these phenotypes for demographic and health outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29301832/pharmacological-inhibition-of-nos-activates-ask1-jnk-pathway-augmenting-docetaxel-mediated-apoptosis-in-triple-negative-breast-cancer
#4
Daniel Dávila-González, Dong Soon Choi, Roberto R Rosato, Sergio Granados-Principal, John G Kuhn, Wen-Feng Li, Wei Qian, Wen Chen, Anthony J Kozielski, Helen H Wong, Bhuvanesh Dave, Jenny C Chang
PURPOSE: Chemoresistance in triple negative breast cancer (TNBC) is associated with the activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress response and by inducible nitric oxide synthase (iNOS). Our aim was to determine the effects of pharmacological NOS-inhibition on TNBC. EXPERIMENTAL DESIGN: TNBC cell lines, SUM-159PT, MDA-MB-436, and MDA-MB-468, were treated with docetaxel and NOS-inibitor (L-NMMA) for 24, 48 and 72 hours...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29298736/multiple-frequency-bioimpedance-devices-for-fluid-management-in-people-with-chronic-kidney-disease-receiving-dialysis-a-systematic-review-and-economic-evaluation
#5
Graham Scotland, Moira Cruickshank, Elisabet Jacobsen, David Cooper, Cynthia Fraser, Michal Shimonovich, Angharad Marks, Miriam Brazzelli
BACKGROUND: Chronic kidney disease (CKD) is a long-term condition requiring treatment such as conservative management, kidney transplantation or dialysis. To optimise the volume of fluid removed during dialysis (to avoid underhydration or overhydration), people are assigned a 'target weight', which is commonly assessed using clinical methods, such as weight gain between dialysis sessions, pre- and post-dialysis blood pressure and patient-reported symptoms. However, these methods are not precise, and measurement devices based on bioimpedance technology are increasingly used in dialysis centres...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29274486/tellurite-resistance-profiles-and-performance-of-different-chromogenic-agars-for-detection-of-non-o157-shiga-toxin-producing-escherichia-coli
#6
Ruyue Fan, Xiangning Bai, Shanshan Fu, Yanmei Xu, Hui Sun, Hong Wang, Yanwen Xiong
Shiga toxin-producing Escherichia coli (STEC) are globally important food-borne pathogens. The isolation of non-O157 STEC is a significant public health challenge due to the dramatic diversity of their phenotypes and genotypes. In the present study, 476 non-O157 STEC strains representing 95 different O-serogroups were used to evaluate tellurite resistance and the performance of 12 different chromogenic agars. Of 476 strains, only 108 (22.7%) strains showed the minimal inhibitory concentration (MIC) values for potassium tellurite being higher than 4μg/ml, and 96 (20...
December 17, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29273416/evaluation-of-18f-labeled-exendin-9-39-derivatives-targeting-glucagon-like-peptide-1-receptor-for-pancreatic-%C3%AE-cell-imaging
#7
Hiroyuki Kimura, Yu Ogawa, Hiroyuki Fujimoto, Eri Mukai, Hidekazu Kawashima, Kenji Arimitsu, Kentaro Toyoda, Naotaka Fujita, Yusuke Yagi, Keita Hamamatsu, Takaaki Murakami, Atsushi Murakami, Masahiro Ono, Yuji Nakamoto, Kaori Togashi, Nobuya Inagaki, Hideo Saji
β-cell mass (BCM) is known to be decreased in subjects with type-2 diabetes (T2D). Quantitative analysis for BCM would be useful for understanding how T2D progresses and how BCM affects treatment efficacy and for earlier diagnosis of T2D and development of new therapeutic strategies. However, a noninvasive method to measure BCM has not yet been developed. We developed four 18F-labeled exendin(9-39) derivatives for β-cell imaging by PET: [18F]FB9-Ex(9-39), [18F]FB12-Ex(9-39), [18F]FB27-Ex(9-39), and [18F]FB40-Ex(9-39)...
December 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29226686/enhanced-specific-activity-by-multi-chelation-of-exendin-3-leads-to-improved-image-quality-and-in-vivo-beta-cell-imaging
#8
Lieke Joosten, Maarten Brom, Hanneke Peeters, Sandra Heskamp, Martin Behe, Otto C Boerman, Martin Gotthardt
OBJECTIVE: Glucagon like peptide-1 receptor (GLP-1R) targeting using radiolabeled exendin is a promising approach to non-invasively visualize and determine beta cell mass (BCM), which could help to unravel the pathophysiology of diabetes. However, saturation of the GLP-1R on beta cells occurs at low peptide doses, since the number of receptors expressed under physiological conditions is low. Therefore, tracers with high specific activities are required to sensitively image small variations in BCM...
December 11, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29194897/reconstitution-of-bicyclomycin-biosynthesis-revealing-a-six-oxidase-cascade-for-tandem-c-h-bond-activation
#9
Song Meng, Wei Han, Juan Zhao, Xiao-Hong Jian, Hai-Xue Pan, Gong-Li Tang
As a commercial antibiotic, bicyclomycin (BCM) is currently the only known natural product targeting the transcription termination factor rho. It belongs to a family of highly functionalized diketopiperazine (DKP) alkaloids which bears a unique O-bridged bicyclo-[4.2.2]piperazinedione ring system, C-1 triol and terminal exomethylene groups. Here we identified and characterized the BCM biosynthetic pathway by heterologous biotransformation, in vitro biochemical assay, and one-pot enzymatic synthesis. A tRNA-dependent cyclodipeptide synthase guides the dimerization of leucine and isoleucine to afford the DKP precursor; subsequently, six redox enzymes including five α-ketoglutarate/Fe2+-dependent dioxygenases and one cytochrome P450 monooxygenase regio- and stereo-selectively install four hydroxyl groups (primary, secondary and two tertiary), an exomethylene moiety, and a medium-sized bridged ring via functionalization of eight unactivated C-H bonds...
November 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29128119/sensitivity-of-water-energy-nexus-to-dam-operation-a-water-energy-productivity-concept
#10
Mohammed Basheer, Nadir Ahmed Elagib
Understanding and modelling the complex nature of interlinkages between water and energy are essential for efficient use of the two resources. Hydropower storage dams represent an interesting example of the water-energy interdependencies since they are often multipurpose. The concept of Water-Energy Productivity (WEP), defined as the amount of energy produced per unit of water lost in the process, is introduced in this study to illustrate the relationship between energy generation and water losses by examining the sensitivity of the Water-Energy Nexus (WEN) to changing dam operation policy...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127911/healthy-minds-from-0-100-years-optimising-the-use-of-european-brain-imaging-cohorts-lifebrain
#11
K B Walhovd, A M Fjell, R Westerhausen, L Nyberg, K P Ebmeier, U Lindenberger, D Bartrés-Faz, W F C Baaré, H R Siebner, R Henson, C A Drevon, G P Knudsen, I Budin-Ljøsne, B W J H Penninx, P Ghisletta, O Rogeberg, L Tyler, L Bertram
The main objective of "Lifebrain" is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5,000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total...
November 8, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29126380/what-makes-for-sound-science
#12
EDITORIAL
Fabrizio Costa, Grant Cramer, E Jean Finnegan
The inclusive threshold policy for publication in BMC journals including BMC Plant Biology means that editorial decisions are largely based on the soundness of the research presented rather than the novelty or potential impact of the work. Here we discuss what is required to ensure that research meets the requirement of scientific soundness. BMC Plant Biology and the other BCM-series journals ( https://www.biomedcentral.com/p/the-bmc-series-journals ) differ in policy from many other journals as they aim to provide a home for all publishable research...
November 10, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29124049/effect-of-personalized-nutritional-counseling-on-the-nutritional-status-of-hemodialysis-patients
#13
In-Young Jo, Woo Jeong Kim, Hyeong Cheon Park, Hoon Young Choi, Jung Eun Lee, Song Mi Lee
This study set out to evaluate the impact of personalized nutritional counseling (PNC) on the nutritional status of hemodialysis (HD) patients. This was an intervention study for 10 months at 2 hospitals. Anthropometric, biochemical, dietary, and body composition parameters were measured at baseline and after 3 and 6 months of PNC. A total of 42 patients (23 men and 19 women) were included. Intake of dietary protein, serum albumin, and cholesterol levels had increased significantly from baseline to month 6 (p < 0...
October 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29110098/do-hydrodynamically-assisted-binary-collisions-lead-to-orientational-ordering-of-microswimmers
#14
Norihiro Oyama, John Jairo Molina, Ryoichi Yamamoto
We have investigated the onset of collective motion in systems of model microswimmers, by performing a comprehensive analysis of the binary collision dynamics using three-dimensional direct numerical simulations (DNS) with hydrodynamic interactions. From this data, we have constructed a simplified binary collision model (BCM) which accurately reproduces the collective behavior obtained from the DNS for most cases. Thus, we show that global alignment can mostly arise solely from binary collisions. Although the agreement between both models (DNS and BCM) is not perfect, the parameter range in which notable differences appear is also that for which strong density fluctuations are present in the system (where pseudo-sound mound can be observed (N...
November 8, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29096210/super-selective-cervical-nerve-root-stimulation-in-contralateral-c7-transfer-an-intraoperative-study
#15
Nora Franziska Dengler, Gregor Antoniadis, Christian Heinen, Brigitta Grolik, Christian Rainer Wirtz, Ralph König, Maria Teresa Pedro
OBJECTIVE: We designed this study using super-selective intraoperative cervical nerve root stimulation aiming to support decision making about complete or partial contralateral C7 (cC7) nerve root transfer in patients with multiple cervical root avulsion injury. METHODS: Super-selective intraoperative stimulations of anterior, lateral, medial and posterior aspect of C5-C8 nerve roots were performed. Compound muscle action potentials (CMAP) were recorded in the lateral part of the deltoid (DM), long head of biceps brachii (BCM), brachioradial (BRM), long head of triceps brachii (TCM), and extensor digitorum communis (EDC) muscle...
December 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29066327/genome-and-methylome-variation-in-helicobacter-pylori-with-a-cag-pathogenicity-island-during-early-stages-of-human-infection
#16
Sandra Nell, Iratxe Estibariz, Juliane Krebes, Boyke Bunk, David Y Graham, Jörg Overmann, Yi Song, Cathrin Spröer, Ines Yang, Thomas Wex, Jonas Korlach, Peter Malfertheiner, Sebastian Suerbaum
BACKGROUND & AIMS: Helicobacter pylori is remarkable for its genetic variation. Yet little isknown about its genetic changes during early stages of human infection, as the bacteria adapt to their new environment. We analyzed genome and methylome variations in a fully virulent strain of H pylori strain during experimental infection. METHODS: We performed a randomized Phase 1 and 2, observer-blind, placebo-controlled, study of 12 healthy, H pylori-negative adults in Germany from October 2008 through March 2010...
October 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29058588/effect-of-infla-kine-supplementation-on-the-gene-expression-of-inflammatory-markers-in-peripheral-mononuclear-cells-and-on-c-reactive-protein-in-blood
#17
Nina A Mikirova, Santosh Kesari, Thomas E Ichim, Neil H Riordan
BACKGROUND: Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer's disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lactobacillus fermentum extract, burdock seed (arctigenin), zinc, alpha lipoic acid, papaya enzyme and an enhanced absorption bio-curcumin complex (BCM-95®). METHODS: Infla-Kine was administered twice daily to 24 health volunteers for 4 weeks. Quantitative RT-PCR was used to assess mRNA transcripts of IL-1b, IL8, IL-6, NF-κB, and TNF-α from peripheral blood mononuclear cells (PBMC)...
October 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29053243/identification-of-the-biosynthetic-pathway-for-the-antibiotic-bicyclomycin
#18
Jon B Patteson, Wenlong Cai, Rachel A Johnson, Kevin C Santa Maria, Bo Li
Diketopiperazines (DKPs) make up a large group of natural products with diverse structures and biological activities. Bicyclomycin is a broad-spectrum DKP antibiotic with unique structure and function: it contains a highly oxidized bicyclic [4.2.2] ring and is the only known selective inhibitor of the bacterial transcription termination factor, Rho. Here, we identify the biosynthetic gene cluster for bicyclomycin containing six iron-dependent oxidases. We demonstrate that the DKP core is made by a tRNA-dependent cyclodipeptide synthase, and hydroxylations on two unactivated sp(3) carbons are performed by two mononuclear iron, α-ketoglutarate-dependent hydroxylases...
November 7, 2017: Biochemistry
https://www.readbyqxmd.com/read/29049735/clinical-and-biological-evaluations-of-biodegradable-collagen-matrices-for-glaucoma-drainage-device-implantation
#19
COMPARATIVE STUDY
Minjung Song, Seunghyun Lee, Deokyeong Choe, Sera Kim, Young Hoon Roh, Seungsoo Rho
Purpose: To characterize the clinical and biological properties of biodegradable collagen matrices (BCMs) for possible glaucoma drainage device implantation. Methods: A total of 68 refractory glaucoma eyes, followed up postoperatively for at least 6 months, were consecutively enrolled after retrospective chart review. The BCM-augmented Ahmed valve implantations (BAAVI) using our Ologen-6 and Ologen-7 valves were performed and compared with a conventional method...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28977791/estimation-of-urinary-creatinine-excretion-and-prediction-of-renal-function-in-morbidly-obese-patients-new-tools-from-body-composition-analysis
#20
Carlo Donadio, Diego Moriconi, Rossana Berta, Marco Anselmino
BACKGROUND/AIMS: In obese subjects the accuracy of prediction of renal function is quite low. The aim of this study was to obtain a more accurate estimate of urinary creatinine excretion (UCr), creatinine clearance (CCr), and GFR from body cell mass (BCM). METHODS: Seventy-three adult morbidly obese patients (BMI 35.2-64.5 kg/m2) were examined. BCM was calculated from body impedance analysis. CCr was measured (mCCr) and was predicted from BCM and antropometric data (MR-BCMCCr), with Cockcroft and Gault (C&GCCr) and Salazar and Corcoran (S&CCCr) formulas...
October 5, 2017: Kidney & Blood Pressure Research
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