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https://www.readbyqxmd.com/read/28817640/evaluation-of-multilocus-marker-efficacy-for-delineating-mangrove-species-of-west-coast-india
#1
Ankush Ashok Saddhe, Rahul Arvind Jamdade, Kundan Kumar
The plant DNA barcoding is a complex and requires more than one marker(s) as compared to animal barcoding. Mangroves are diverse estuarine ecosystem prevalent in the tropical and subtropical zone, but anthropogenic activity turned them into the vulnerable ecosystem. There is a need to build a molecular reference library of mangrove plant species based on molecular barcode marker along with morphological characteristics. In this study, we tested the core plant barcode (rbcL and matK) and four promising complementary barcodes (ITS2, psbK-psbI, rpoC1 and atpF-atpH) in 14 mangroves species belonging to 5 families from West Coast India...
2017: PloS One
https://www.readbyqxmd.com/read/28777876/qualitative-analysis-of-psoraleae-fructus-by-hplc-dad-tof-ms-fingerprint-and-quantitative-analysis-of-multi-components-by-single-marker
#2
Lianjun Luan, Xiaoyu Shen, Xuesong Liu, Yongjiang Wu, ManliangTan
A variety of bioactive substances may account for the recognized efficacy and wide clinical application of Psoraleae Fructus in China. A high performance liquid chromatography-diode array detector (HPLC-DAD) fingerprint method was developed to present the comprehensive phytochemical profile of the crude drug. Thirteen major compounds were separated and identified by high performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC/TOF-MS), namely psoralenoside (PO), isopsoralenoside (IPO), psoralen (PS), isopsoralen (IPS), neobavaisoflavone (NBF), bavachin (BC), corylin (CN), bavachromene (BCM), psoralidin (PD), isobavachalcone (IBC), bacachinin (BCN), corylifol A (CA), bakuchiol (BK)...
August 4, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28775287/non-invasive-in-vivo-determination-of-viable-islet-graft-volume-by-111-in-exendin-3
#3
Wael A Eter, Inge Van der Kroon, Karolina Andralojc, Mijke Buitinga, Stefanie M A Willekens, Cathelijne Frielink, Desiree Bos, Lieke Joosten, Otto C Boerman, Maarten Brom, Martin Gotthardt
Pancreatic islet transplantation is a promising therapy for patients with type 1 diabetes. However, the duration of long-term graft survival is limited due to inflammatory as well as non-inflammatory processes and routine clinical tests are not suitable to monitor islet survival. (111)In-exendin-SPECT (single photon emission computed tomography) is a promising method to non-invasively image islets after transplantation and has the potential to help improve the clinical outcome. Whether (111)In-exendin-SPECT allows detecting small differences in beta-cell mass (BCM) and measuring the actual volume of islets that were successfully engrafted has yet to be demonstrated...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751656/gene-based-therapy-in-a-mouse-model-of-blue-cone-monochromacy
#4
Yuxin Zhang, Wen-Tao Deng, Wei Du, Ping Zhu, Jie Li, Fan Xu, Jingfen Sun, Cecilia D Gerstner, Wolfgang Baehr, L Boye Sanford, Chen Zhao, William W Hauswirth, Ji-Jing Pang
Cones are responsible for daylight, central, high acuity and color vision. Three proteins found in human cones, i.e. long-wavelength (L)-, middle-wavelength (M)-, and short-wavelength sensitive (S)-opsins, are responsible for red, green and blue color recognition, respectively. Human blue cone monochromacy (BCM) is characterized by functional loss of both L- and M-cone opsins due to mutations in the OPN1LW/OPN1MW gene cluster on the X chromosome. BCM patients, who rely on their vision from only S-cones and rods, suffer severely reduced visual acuity and impaired color vision...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28651860/fractional-fetal-thigh-volume-in-the-prediction-of-normal-and%C3%A2-abnormal-fetal-growth-during-the-third-trimester-of%C3%A2-pregnancy
#5
Louise E Simcox, Jenny E Myers, Tim J Cole, Edward D Johnstone
BACKGROUND: Currently, 2-dimensional ultrasound estimation of fetal size rather than fetal growth is used to define fetal growth restriction, but single estimates in late pregnancy lack sensitivity and may identify small for gestational age rather than growth restriction. Single or longitudinal measures of 3-dimensional fractional thigh volume may address this problem. OBJECTIVE: We sought to derive normal values for 3-dimensional fractional thigh volume in the third trimester, determine if fractional thigh volume is superior to 2-dimensional ultrasound biometry alone for detecting fetal growth restriction, and determine whether individualized growth assessment parameters have the potential to identify fetal growth restriction remote from term delivery...
June 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28643022/androgen-receptor-expression-and-breast-cancer-mortality-in-a-population-based-prospective-cohort
#6
Karin Elebro, Pär-Ola Bendahl, Helena Jernström, Signe Borgquist
PURPOSE: The increase in clinical trials with androgen receptor (AR)-targeting drugs emphasizes the need of clarifying the role of AR expression in different breast cancer subtypes. AR confers good prognosis in estrogen receptor positive (ER+) breast cancer, but its role in ER-negative (ER-) breast cancer is unclear. The aim of this study was to elaborate on previous findings of a differential prognostic role for AR depending on ER status, using breast cancer mortality (BCM) as endpoint, in a population-based cohort from the Malmö Diet and Cancer Study...
June 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28622513/comprehensive-and-integrative-genomic-characterization-of-hepatocellular-carcinoma
#7
(no author information available yet)
Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, and SMARCA4. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APOB, and CPS1) were observed...
June 15, 2017: Cell
https://www.readbyqxmd.com/read/28613081/maintenance-of-negative-fluid-balance-can-improve-endothelial-and-cardiac-functions-in-primary-hypertensive-patients
#8
Ali Yeşiltepe, Oguzhan Sıtkı Dizdar, Hasan Gorkem, Engin Dondurmacı, Eyup Ozkan, Ali Koç, Ahmet Oguz Baktır, Ali Ihsan Gunal
PURPOSE: The issue of unidentified volume expansion is well recognized as a cause for resistance to antihypertensive therapy. The aim of study is to identify contribution of negative fluid balance to hypertension control and impact on endothelial and cardiac functions among primary hypertensive patients who do not have kidney failure. MATERIALS AND METHODS: This is a prospective interventional study with one-year follow-up. Preceded by volume status measurements were performed by a body composition monitor (BCM), the patients were put on ambulatory blood pressure monitoring for 24 hours...
June 14, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28599115/recurrent-information-optimization-with-local-metaplastic-synaptic-dynamics
#9
Sensen Liu, ShiNung Ching
We consider the problem of optimizing information-theoretic quantities in recurrent networks via synaptic learning. In contrast to feedforward networks, the recurrence presents a key challenge insofar as an optimal learning rule must aggregate the joint distribution of the whole network. This challenge, in particular, makes a local policy (i.e., one that depends on only pairwise interactions) difficult. Here, we report a local metaplastic learning rule that performs approximate optimization by estimating whole-network statistics through the use of several slow, nested dynamical variables...
June 9, 2017: Neural Computation
https://www.readbyqxmd.com/read/28559482/a-screen-for-rfah-suppressors-reveals-a-key-role-for-a-connector-region-of-termination-factor-rho
#10
Kuang Hu, Irina Artsimovitch
RfaH activates horizontally acquired operons that encode lipopolysaccharide core components, pili, toxins, and capsules. Unlike its paralog NusG, which potentiates Rho-mediated silencing, RfaH strongly inhibits Rho. RfaH is recruited to its target operons via a network of contacts with an elongating RNA polymerase (RNAP) and a specific DNA element called ops to modify RNAP into a pause- and NusG-resistant state. rfaH null mutations confer hypersensitivity to antibiotics and detergents, altered susceptibility to bacteriophages, and defects in virulence...
May 30, 2017: MBio
https://www.readbyqxmd.com/read/28555040/body-composition-analysis-allows-the-prediction-of-urinary-creatinine-excretion-and-of-renal-function-in-chronic-kidney-disease-patients
#11
Carlo Donadio
The aim of this study was to predict urinary creatinine excretion (UCr), creatinine clearance (CCr) and the glomerular filtration rate (GFR) from body composition analysis. Body cell mass (BCM) is the compartment which contains muscle mass, which is where creatinine is generated. BCM was measured with body impedance analysis in 165 chronic kidney disease (CKD) adult patients (72 women) with serum creatinine (SCr) 0.6-14.4 mg/dL. The GFR was measured ((99m)Tc-DTPA) and was predicted using the Modification of Diet in Renal Disease (MDRD) formula...
May 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28546540/a-bioactive-chemical-markers-based-strategy-for-quality-assessment-of-botanical-drugs-xuesaitong-injection-as-a-case-study
#12
Zhenzhong Yang, Qing Shao, Zhiwei Ge, Ni Ai, Xiaoping Zhao, Xiaohui Fan
Current chemical markers based quality assessment methods largely fail to reflect intrinsic chemical complexity and multiple mechanisms of action of botanical drugs (BD). The development of novel quality markers is greatly needed. Here we propose bioactive chemical markers (BCM), defined as a group of chemo-markers that exhibit similar pharmacological activities comparable to the whole BD, which can therefore be used to effectively assess the quality of BD. As a proof-of-concept, a BCM-based strategy was developed and applied to Xuesaitong Injection (XST) for assessing the efficacy and consistency of different batches...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28541456/crisprcloud-a-secure-cloud-based-pipeline-for-crispr-pooled-screen-deconvolution
#13
Hyun-Hwan Jeong, Seon Young Kim, Maxime Wc Rousseaux, Huda Y Zoghbi, Zhandong Liu
Summary: We present a user-friendly, cloud-based, data analysis pipeline for the deconvolution of pooled screening data. This tool, CRISPRcloud, serves a dual purpose of extracting, clustering and analyzing raw next generation sequencing files derived from pooled screening experiments while at the same time presenting them in a user-friendly way on a secure web-based platform. Moreover, CRISPRcloud serves as a useful web-based analysis pipeline for reanalysis of pooled CRISPR screening datasets...
May 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28481116/overcoming-the-road-blocks-advancement-of-block-copolymer-micelles-for-cancer-therapy-in-the-clinic
#14
Loujin Houdaihed, James C Evans, Christine Allen
With countless preclinical studies on block copolymer micelles (BCMs) successfully demonstrating the superiority of these advanced drug delivery formulations over conventional formulations, it remains somehow discouraging that only a few have reached clinical evaluation and practice. With a critical eye, this review aims to compare and summarize the preclinical and clinical data available on several BCM formulations and to identify their primary role in drug delivery as "carrier" or "solubilizer". This review focuses on polymeric micelles that have reached clinical evaluation and/or are being pursued commercially...
August 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28465219/differences-in-body-composition-according-to-gross-motor-function-in-children-with-cerebral-palsy
#15
Ki Hyuk Sung, Chin Youb Chung, Kyoung Min Lee, Byung Chae Cho, Seung Jun Moon, Jaeyoung Kim, Moon Seok Park
OBJECTIVES: To assess differences in body composition according to gross motor function in children with cerebral palsy (CP) compared to healthy controls. DESIGN: Retrospective case control study. SETTING: Tertiary referral center for CP PARTICIPANTS: One hundred consecutive patients (mean age, 11.5 ± 4.2 years) with CP who were admitted for orthopedic surgery between May 2014 and March 2016 and 46 typically developing children (TDC, control group) were included...
April 29, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28465075/carbon-nanotube-capsules-enhance-the-in-vivo-efficacy-of-cisplatin
#16
Adem Guven, Gabriel J Villares, Susan G Hilsenbeck, Alaina Lewis, John D Landua, Lacey E Dobrolecki, Lon J Wilson, Michael T Lewis
Over the past few years, numerous nanotechnology-based drug delivery systems have been developed in an effort to maximize therapeutic effectiveness of conventional drug delivery, while limiting undesirable side effects. Among these, carbon nanotubes (CNTs) are of special interest as potential drug delivery agents due to their numerous unique and advantageous physical and chemical properties. Here, we show in vivo favorable biodistribution and enhanced therapeutic efficacy of cisplatin (CDDP) encapsulated within ultra-short single-walled carbon nanotube capsules (CDDP@US-tubes) using three different human breast cancer xenograft models...
May 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28448447/factors-associated-with-decreased-lean-tissue-index-in-patients-with-chronic-kidney-disease
#17
Yi-Wen Wang, Ting-Yun Lin, Ching-Hsiu Peng, Jui-Lin Huang, Szu-Chun Hung
Muscle wasting is common and is associated with increased morbidity and mortality in patients with chronic kidney disease (CKD). However, factors associated with decreased muscle mass in CKD patients are seldom reported. We performed a cross-sectional study of 326 patients (age 65.8 ± 13.3 years) with stage 3-5 CKD who were not yet on dialysis. Muscle mass was determined using the Body Composition Monitor (BCM), a multifrequency bioimpedance spectroscopy device, and was expressed as the lean tissue index (LTI, lean tissue mass/height²)...
April 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28426660/exhaustive-search-of-linear-information-encoding-protein-peptide-recognition
#18
Abdellali Kelil, Benjamin Dubreuil, Emmanuel D Levy, Stephen W Michnick
High-throughput in vitro methods have been extensively applied to identify linear information that encodes peptide recognition. However, these methods are limited in number of peptides, sequence variation, and length of peptides that can be explored, and often produce solutions that are not found in the cell. Despite the large number of methods developed to attempt addressing these issues, the exhaustive search of linear information encoding protein-peptide recognition has been so far physically unfeasible...
April 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28399948/method-for-estimating-the-charge-density-distribution-on-a-dielectric-surface
#19
Takuya Nakashima, Hiroyuki Suhara, Hidekazu Murata, Hiroshi Shimoyama
High-quality color output from digital photocopiers and laser printers is in strong demand, motivating attempts to achieve fine dot reproducibility and stability. The resolution of a digital photocopier depends on the charge density distribution on the organic photoconductor surface; however, directly measuring the charge density distribution is impossible. In this study, we propose a new electron optical instrument that can rapidly measure the electrostatic latent image on an organic photoconductor surface, which is a dielectric surface, as well as a novel method to quantitatively estimate the charge density distribution on a dielectric surface by combining experimental data obtained from the apparatus via a computer simulation...
April 12, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28383400/protocol-of-randomized-control-trial-for-effectiveness-of-angiotensin-receptor-blockers-on-blood-pressure-control-among-euvolemic-hypertensive-hemodialysis-patients
#20
RANDOMIZED CONTROLLED TRIAL
Raja Ahsan Aftab, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Tahir Mehmood Khan, Azreen Syazril Adnan
INTRODUCTION: Volume overload and the renin-aldosterone-angiotensin system (RAAS) are 2 major factors contributing to hypertension (HTN) among hemodialysis (HD) patients. Although volume-dependent components of HTN can be corrected by appropriate volume removal, a proportion of HD patients experience elevated blood pressure (BP) despite achieving euvolemic and ideal dry weight. METHOD AND ANALYSIS: A single center, prospective, randomized, parallel design, single-blind trial will be conducted in the Malaysian state of Kelantan among postdialysis euvolemic hypertensive patients that are on regular dialysis at least 3 times a week...
April 2017: Medicine (Baltimore)
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