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https://www.readbyqxmd.com/read/28333979/the-interaction-between-fluid-status-and-angiopoietin-2-in-adverse-renal-outcomes-of-chronic-kidney-disease
#1
Yi-Chun Tsai, Yi-Wen Chiu, Hung-Tien Kuo, Jia-Jung Lee, Su-Chu Lee, Tzu-Hui Chen, Ming-Yen Lin, Shang-Jyh Hwang, Mei-Chuan Kuo, Ya-Ling Hsu, Hung-Chun Chen
BACKGROUND: Fluid overload is not only the characteristic but also an important complication in chronic kidney disease (CKD) patients. Angiopoietin-2 (Angpt2) disturbs endothelium and vessel permeability, which may induce fluid overload. The aim of this study is to examine the interaction between fluid status and Angpt2 in adverse renal outcomes of CKD. METHODS: This cohort study enrolled 290 patients with CKD stages 3-5 from January 2011 to December 2011 and followed up until December 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28328660/addressing-the-barriers-to-bioimpedance-spectroscopy-use-in-major-burns-alternate-electrode-placement
#2
Pippa Kenworthy, Tiffany L Grisbrook, Michael Phillips, William Gibson, Fiona M Wood, Dale W Edgar
Bioimpedance spectroscopy (BIS) is a method used to assess body composition and fluid distribution. As a technology for measurement of fluid shifts during acute burn resuscitation, there are potential barriers to its use due to the location of wounds. This study aimed to determine whether alternate electrode positions were a suitable alternative compared to standardized (manufacturer) positions in moderate to large size burns for the measurement of BIS resistance and fluid changes. BIS measurements were collected in standard and alternate electrode placements and in an open wound and Acticoat™ dressing condition...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28326349/quantitative-in-vivo-micro-computed-tomography-for-assessment-of-age-dependent-changes-in-murine-whole-body-composition
#3
Kim L Beaucage, Steven I Pollmann, Stephen M Sims, S Jeffrey Dixon, David W Holdsworth
Micro-computed tomography (micro-CT) is used routinely to quantify skeletal tissue mass in small animal models. Our goal was to evaluate repeated in vivo micro-CT imaging for monitoring whole-body composition in studies of growth and aging in mice. Male mice from 2 to 52 weeks of age were anesthetized and imaged using an eXplore Locus Ultra and/or eXplore speCZT scanner. Images were reconstructed into 3D volumes, signal-intensity thresholds were used to classify each voxel as adipose, lean or skeletal tissue, and tissue masses were calculated from known density values...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28303338/blood-glucose-kinetics-and-physiological-changes-in-a-type-1-diabetic-finisher-of-the-ultraman-triathlon-a-case-study
#4
Christopher W Bach, Daniel A Baur, William S Hyder, Michael J Ormsbee
PURPOSE: To investigate the blood glucose kinetics and physiological effects experienced by a type 1 diabetic (T1D) finisher of a 3-day, multi-stage ultra endurance triathlon consisting of a 10 km swim and 144.8 km bike (stage 1), a 275.4 km bike (stage 2), and an 84.4 km run (stage 3). METHODS: The athlete self-monitored blood glucose (SMBG) levels via fingerstick blood draw and hand-held glucometer. Researchers evaluated blood glucose kinetics via a continuous glucose monitoring device...
March 16, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28296943/new-approaches-to-determine-fatigue-in-elite-athletes-during-intensified-training-resting-metabolic-rate-and-pacing-profile
#5
Amy L Woods, Laura A Garvican-Lewis, Bronwen Lundy, Anthony J Rice, Kevin G Thompson
BACKGROUND: Elite rowers complete a high volume of training across a number of modalities to prepare for competition, including periods of intensified load, which may lead to fatigue and short-term performance decrements. As yet, the influence of substantial fatigue on resting metabolic rate (RMR) and exercise regulation (pacing), and their subsequent utility as monitoring parameters, has not been explicitly investigated in elite endurance athletes. METHOD: Ten National-level rowers completed a four-week period of intensified training...
2017: PloS One
https://www.readbyqxmd.com/read/28291615/seasonal-patterns-of-water-quality-and-phytoplankton-dynamics-in-surface-waters-in-guangzhou-and-foshan-china
#6
Yanggui Xu, Adela Jing Li, Junhao Qin, Qi Li, Jonathan G Ho, Huashou Li
During 2015, we studied the temporal patterns of nutrient concentrations and turbidity in water bodies with different degrees of agricultural and urban pressures across Guangzhou and Foshan (China). Data and observations were made by trained citizen scientists and professional researchers. Our study shows that all monitored water bodies, with the exception of Qiandeng Lake and Fengjiang River, had elevated NO3(-)-N concentrations, which ranged from 0.10 to 6.83mg/L and peaked in late winter and early spring and reached a minimum in summer and mid-autumn...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28291490/proposing-using-waist-to-height-ratio-as-the-initial-metric-for-body-fat-assessment-standards-in-the-u-s-army
#7
Stephen A Bernstein, Michael Lo, W Sumner Davis
OBJECTIVES: Soldiers failing to meet Army Regulation 600-9 (AR 600-9) for weight-to-height standards are required to undergo body fat taping assessment. This article describes a clinical performance improvement project in which battalion medical staff identified a simpler way to improve on meeting AR 600-9 standards with proposing to use the waist-to-height ratio (WtHR) in place of the current methodology. METHODS: During a yearlong combat deployment to Iraq from 2009 to 2010, 42 Soldiers (34 males, 8 females) were evaluated and monitored by battalion medical staff for weight and body fat loss...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28286320/earwax-a-neglected-body-secretion-or-a-step-ahead-in-clinical-diagnosis-a-pilot-study
#8
Engy Shokry, Anselmo Elcana de Oliveira, Melissa Ameloti Gomes Avelino, Mariana Moreira de Deus, Nelson Roberto Antoniosi Filho
This work combines the advantages of volatile metabolites profiling as a young growing research field with a non-invasive sampling technique using earwax "a neglected body secretion" for detection and monitoring of biomarkers for diabetes mellitus (types 1 and 2). Earwax samples were collected from 26 diabetic patients of both types, analyzed by headspace gas chromatography mass spectrometry and confronted to the volatile earwax composition of 33 healthy individuals. Data mining analysis was conducted using different models to discriminate the healthy individuals from the diabetic patients and to discriminate between both types of diabetes as well...
March 9, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28285656/relationships-of-insulin-like-growth-factor-1-its-binding-proteins-and-cardiometabolic-risk-in-hypertensive-perimenopausal-women
#9
Agnieszka Olszanecka, Aneta Dragan, Kalina Kawecka-Jaszcz, Danuta Fedak, Danuta Czarnecka
PURPOSE: During the transition from premenopause to postmenopause, many women experience weight gain and central fat deposition; therefore, we hypothesized that circulating growth factors can play a role in the pathogenesis of hypertension, metabolic syndrome, and subclinical organ damage in perimenopausal women. BASIC PROCEDURES: The study included 192 women aged 40 to 60years; 152 had newly diagnosed essential hypertension that had never been treated, and 40 were normotensive age-matched controls...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28281355/systemic-effects-of-ionizing-radiation-at-the-proteome-and-metabolome-levels-in-the-blood-of-cancer-patients-treated-with-radiotherapy-the-influence-of-inflammation-and-radiation-toxicity
#10
Karol Jelonek, Monika Pietrowska, Piotr Widlak
Purpose Blood is the most common replacement tissue used to study systemic responses of organisms to different types of pathological conditions and environmental insults. Local irradiation during cancer radiotherapy induces whole body responses that can be observed at the blood proteome and metabolome levels. Hence, comparative blood proteomics and metabolomics are emerging approaches used in the discovery of radiation biomarkers. These techniques enable the simultaneous measurement of hundreds of molecules and the identification of sets of components that can discriminate different physiological states of the human body...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281337/recent-advancements-in-flexible-and-stretchable-electrodes-for-electromechanical-sensors-strategies-materials-and-features
#11
Songfang Zhao, Jinhui Li, Duxia Cao, Guoping Zhang, Jia Li, Kui Li, Yang Yang, Wei Wang, Yufeng Jin, Rong Sun, Ching-Ping Wong
Stretchable and flexible sensors attached onto the surface of human body can perceive external stimuli, thus attracting extensive attention due to their lightweight, low modulus, low cost, high flexibility, and stretchability. Recently, a myriad of efforts have been devoted to improve the performance and functionality of wearable sensors. Herein, this reviews focuses on recent remarkable advancements in the development of flexible and stretchable sensors. Multifunction of these wearable sensors is realized by incorporating some desired features (e...
March 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28271595/independent-academic-data-monitoring-committees-for-clinical-trials-in-cardiovascular-and-cardiometabolic-diseases
#12
Gerasimos S Filippatos, Pieter de Graeff, Jeroen J Bax, John-Joseph Borg, John G F Cleland, Henry J Dargie, Marcus Flather, Ian Ford, Tim Friede, Barry Greenberg, Cécile Henon-Goburdhun, Richard Holcomb, Bradley Horst, John Lekakis, Guenther Mueller-Velten, Athanasios G Papavassiliou, Krishna Prasad, Giuseppe M C Rosano, Thomas Severin, Warren Sherman, Wendy Gattis Stough, Karl Swedberg, Luigi Tavazzi, Dimitris Tousoulis, Panagiotis Vardas, Frank Ruschitzka, Stefan D Anker
Data Monitoring Committees (DMCs) play a crucial role in the conducting of clinical trials to ensure the safety of study participants and to maintain a trial's scientific integrity. Generally accepted standards exist for DMC composition and operational conduct. However, some relevant issues are not specifically addressed in current guidance documents, resulting in uncertainties regarding optimal approaches for communication between the DMC, steering committee, and sponsors, release of information, and liability protection for DMC members...
March 8, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28265064/multisensor-integrated-organs-on-chips-platform-for-automated-and-continual-in-situ-monitoring-of-organoid-behaviors
#13
Yu Shrike Zhang, Julio Aleman, Su Ryon Shin, Tugba Kilic, Duckjin Kim, Seyed Ali Mousavi Shaegh, Solange Massa, Reza Riahi, Sukyoung Chae, Ning Hu, Huseyin Avci, Weijia Zhang, Antonia Silvestri, Amir Sanati Nezhad, Ahmad Manbohi, Fabio De Ferrari, Alessandro Polini, Giovanni Calzone, Noor Shaikh, Parissa Alerasool, Erica Budina, Jian Kang, Nupura Bhise, João Ribas, Adel Pourmand, Aleksander Skardal, Thomas Shupe, Colin E Bishop, Mehmet Remzi Dokmeci, Anthony Atala, Ali Khademhosseini
Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28264796/feasibility-and-acceptability-of-a-wearable-technology-physical-activity-intervention-with-telephone-counseling-for-mid-aged-and-older-adults-a-randomized-controlled-pilot-trial
#14
Elizabeth J Lyons, Maria C Swartz, Zakkoyya H Lewis, Eloisa Martinez, Kristofer Jennings
BACKGROUND: As adults age, their physical activity decreases and sedentary behavior increases, leading to increased risk of negative health outcomes. Wearable electronic activity monitors have shown promise for delivering effective behavior change techniques. However, little is known about the feasibility and acceptability of non-Fitbit wearables (Fitbit, Inc, San Francisco, California) combined with telephone counseling among adults aged more than 55 years. OBJECTIVE: The purpose of our study was to determine the feasibility, acceptability, and effect on physical activity of an intervention combining a wearable physical activity monitor, tablet device, and telephone counseling among adults aged 55-79 years...
March 6, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28261757/physical-function-quality-of-life-and-energy-expenditure-during-activities-of-daily-living-in-obese-post-bariatric-surgery-and-healthy-subjects
#15
Fabiane Monteiro, Diego A N Ponce, Humberto Silva, Fabio Pitta, Alexandre J F Carrilho
OBJECTIVES: This study aimed to evaluate physical function (PF), quality of life (QOL), and energy expenditure (EE) during activities of daily living (ADL) in late outcome post-bariatric surgery (BS) patients and to compare them to severe obese individuals and matched controls. METHODS: Sixty-three subjects were included: 21 patients in post-operative (PO) of BS (3-4 years post-Roux-en-Y gastric bypass) with a stable weight for at least 6 months (16 women, 41 ± 11 years old, BMI = 28 ± 4 kg m(-2)) (group PO); 21 obese individuals with BS indication (16 women, 44 ± 9 years old, BMI = 44 ± 6 kg m(-2)) (group OB); and 21 controls matched to PO by gender, age, and BMI (16 women, 42 ± 12 years old, BMI = 27 ± 6 kg m(-2)) (group MC)...
March 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28257583/the-oral-cavity-microbiota-between-health-oral-disease-and-cancers-of-the-aerodigestive-tract
#16
Pierre Le Bars, Sebastien Metamoros, Emmanuel Montassier, Françoise Le Vacon, Gilles Potel, Assem Soueidan, Fabienne Jordana, Marie-France De La Cochétière
Many studies show that the human microbiome plays a critical role in the chronic pathologies of obesity, inflammatory bowel diseases, and diabetes. More recently, the interaction between cancer and the microbiome has been highlighted. Most studies have focused on the gut microbiota because it represents the most extensive bacterial community, and the body of evidence correlating it with gut syndromes is increasing. However, in the strict sense, the gastrointestinal (GI) tract begins in the oral cavity, and special attention should be paid to the specific flora of this cavity...
March 3, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28257095/micronutrient-status-in-153-patients-with-anorexia-nervosa
#17
Najate Achamrah, Moïse Coëffier, Agnès Rimbert, Jocelyne Charles, Vanessa Folope, André Petit, Pierre Déchelotte, Sébastien Grigioni
Micronutrient status in Anorexia Nervosa (AN) has been poorly documented and previous data are often contradictory. We aimed to assess micronutrient status in a large population of AN patients. The relationships between micronutrient status and body composition were also determined. Anthropometric, biochemical parameters and body composition data were collected at referral in 153 patients with AN (28.5 ± 11 years). At least one trace element deficit was observed in almost half of patients; the most frequent was selenium deficit (40% of patients)...
March 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28253030/case-study-the-effect-of-32-weeks-of-figure-contest-preparation-on-a-self-proclaimed-drug-free-female-s-lean-body-and-bone-mass
#18
John Petrizzo, Frederick J DiMenna, Kimberly Martins, John Wygand, Robert M Otto
To achieve the criterion appearance prior to competing in a physique competition, athletes undergo preparatory regimens involving high-volume intense resistance and aerobic exercise with hypocaloric energy intake. As the popularity of "drug-free" competition increases, more athletes are facing this challenge without the recuperative advantage provided by performance-enhancing drugs. Consequently, the likelihood of loss of lean body and/or bone mass is increased. The purpose of this investigation was to monitor changes in body composition for a 29-year-old self-proclaimed drug-free female figure competitor during a 32-week preparatory regimen comprising high-volume resistance and aerobic exercise with hypocaloric energy intake...
March 2, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28249783/diet-driven-microbiota-dysbiosis-is-associated-with-vagal-remodeling-and-obesity
#19
Tanusree Sen, Carolina R Cawthon, Benjamin Thomas Ihde, Andras Hajnal, Patricia M DiLorenzo, Claire B de La Serre, Krzysztof Czaja
Obesity is one of the major health issues in the United States. Consumption of diets rich in energy, notably from fats and sugars (high-fat/high-sugar diet: HF/HSD) is linked to the development of obesity and a popular dietary approach for weight loss is to reduce fat intake. Obesity research traditionally uses low and high fat diets and there has been limited investigation of the potential detrimental effects of a low-fat/high-sugar diet (LF/HSD) on body fat accumulation and health. Therefore, in the present study, we investigated the effects of HF/HSD and LF/HSD on microbiota composition, gut inflammation, gut-brain vagal communication and body fat accumulation...
February 26, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28244706/-her-shape-intervention-programme-for-obese-women-with-high-breast-adiposity
#20
Norsham Juliana, Suzana Shahar, Mohd Azmani Sahar, Ahmad Rohi Ghazali, Zahara Abdul Manaf, Rahim Md Noah
BACKGROUND AND OBJECTIVES: Nutrition and physical activity interventions is beneficial in reversing obesity. However far too little attention has been paid to the effect of these interventions on breast tissues. Thus, the aim of this study was to explore the effect of a home-based dietary and physical activity intervention (the Her Shape Program) on metabolic parameters, blood biomarkers and adiposity at the breast. METHODS AND STUDY DESIGN: A randomized controlled study was conducted on obese women with high breast adiposity (<0...
March 2017: Asia Pacific Journal of Clinical Nutrition
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