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https://www.readbyqxmd.com/read/29792747/interpretation-time-using-a-concurrent-read-computer-aided-detection-system-for-automated-breast-ultrasound-in-breast-cancer-screening-of-women-with-dense-breast-tissue
#1
Yulei Jiang, Marc F Inciardi, Alexandra V Edwards, John Papaioannou
OBJECTIVE: The purpose of this study was to compare diagnostic accuracy and interpretation time of screening automated breast ultrasound (ABUS) for women with dense breast tissue without and with use of a recently U.S. Food and Drug Administration-approved computer-aided detection (CAD) system for concurrent read. MATERIALS AND METHODS: In a retrospective observer performance study, 18 radiologists interpreted a cancer-enriched set (i.e., cancer prevalence higher than in the original screening cohort) of 185 screening ABUS studies (52 with and 133 without breast cancer)...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792725/novel-breast-imaging-and-machine-learning-predicting-breast-lesion-malignancy-at-cone-beam-ct-using-machine-learning-techniques
#2
Johannes Uhlig, Annemarie Uhlig, Meike Kunze, Tim Beissbarth, Uwe Fischer, Joachim Lotz, Susanne Wienbeck
OBJECTIVE: The purpose of this study is to evaluate the diagnostic performance of machine learning techniques for malignancy prediction at breast cone-beam CT (CBCT) and to compare them to human readers. SUBJECTS AND METHODS: Five machine learning techniques, including random forests, back propagation neural networks (BPN), extreme learning machines, support vector machines, and K-nearest neighbors, were used to train diagnostic models on a clinical breast CBCT dataset with internal validation by repeated 10-fold cross-validation...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29790381/what-do-tsecs-provide-in-the-menopausal-hormone-therapy
#3
Placido Llaneza, Joaquim Calaf, Ana Rosa Jurado, Nicolas Mendoza, Borja Otero, Francisco Quereda, Rafael Sánchez-Borrego, Daniel Lubian
Tissue-selective estrogen complex (TSEC) is projected as a progestogen-free option for the treatment of estrogen deficiency symptoms in postmenopausal, non-hysterectomized women. TSEC combines the benefits of estrogen with a selective estrogen receptor modulator (SERM), in this case bazedoxifene acetate (BZA), which has an antagonistic effect on the endometrium, thus avoiding the use of progestins. The authorized TSEC combination (conjugated estrogens [CE] 0.45 mg/BZA 20 mg) for the alleviation of vasomotor symptoms has been demonstrated in randomized clinical trials compared with placebo or menopausal hormone therapy (MHT)...
May 23, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29790170/calculation-of-breast-volumes-from-mammogram-comparison-of-four-separate-equations-relative-to-mastectomy-specimen-volumes
#4
Jack W Rostas, Neal Bhutiani, Morgan Crigger, Stacey M W Crawford, Reiss B Hollenbach, Samantha R Heidrich, Robert C G Martin, Kelly M McMasters, Nicolás Ajkay
BACKGROUND AND OBJECTIVES: Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. METHODS: Mammography data was obtained for patients who underwent mastectomy for breast cancer from 2005 to 2015. This data was used to calculate BV using four previously published equations...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29788490/effects-of-a-protease-and-essential-oils-on-growth-performance-blood-cell-profiles-nutrient-retention-ileal-microbiota-excreta-gas-emission-and-breast-meat-quality-in-broiler-chicks
#5
J H Park, I H Kim
A total of 360 Ross male broiler chicks (39.8 ± 1.8 g) were used in a five week experiment to determine the effect of a protease and essential oils (EO) on growth performance, blood cell profile, nutrient retention, ileal microbiota, excreta gas emission, and breast meat quality in broiler chicks. Broiler chicks were randomly allotted to four dietary treatments with 15 birds/cage and six cages/treatment. Experimental treatments were arranged as a 2 × 2 factorial with two levels of protease (0 and 0.02%) and two levels of EO (0 and 0...
May 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29776156/realizations-of-highly-heterogeneous-collagen-networks-via-stochastic-reconstruction-for-micromechanical-analysis-of-tumor-cell-invasion
#6
Hanqing Nan, Long Liang, Guo Chen, Liyu Liu, Ruchuan Liu, Yang Jiao
Three-dimensional (3D) collective cell migration in a collagen-based extracellular matrix (ECM) is among one of the most significant topics in developmental biology, cancer progression, tissue regeneration, and immune response. Recent studies have suggested that collagen-fiber mediated force transmission in cellularized ECM plays an important role in stress homeostasis and regulation of collective cellular behaviors. Motivated by the recent in vitro observation that oriented collagen can significantly enhance the penetration of migrating breast cancer cells into dense Matrigel which mimics the intravasation process in vivo [Han et al...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29770894/efficacy-of-punarnavine-in-restraining-organ-specific-tumour-progression-in-4t1-induced-murine-breast-tumour-model
#7
Gilcy George Kallivalappil, Girija Kuttan
Most of the breast cancer deaths occur when cancer cells depart from their tumour of origin and spread systemically and colonise distant organs. The present study was to find out whether punarnavine, the quinolizidine alkaloid, with already proven antimetastatic effect on spontaneous B16F10 pulmonary metastasis has got any effect on a drastic organ-specific breast cancer spread. For the study, we selected a syngenic mouse 4T1 breast tumour model that mimics stage four of human breast cancer. The metastatic progression of 4T1 to lymph nodes, lungs, and liver was reduced by punarnavine (40 mg/kg body weight) administration in BALB/c mice...
May 17, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29768474/sonographic-visualization-of-nipple-blood-flow-can-help-differentiate-paget-disease-from-benign-eczematous-nipple-lesions
#8
Hideaki Ogata, Yukio Mitsuzuka, Naoko Honma, Miho Yoshida, Makoto Sumazaki, Fumi Saito, Masahiro Kobayashi, Kazutoshi Shibuya, Tetsuo Mikami, Hironori Kaneko
PURPOSE: Paget disease of the breast is a rare cancer that originates from the nipple-areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease. METHODS: In this retrospective study, 12 patients with pathologically proven unilateral nipple eczematous lesions (seven with Paget disease and five with simple dermatitis) were included...
2018: PloS One
https://www.readbyqxmd.com/read/29767109/nutrient-density-of-prestarter-diets-from-1-to-10-days-of-age-affects-intestinal-morphometry-enzyme-activity-serum-indices-and-performance-of-broiler-chickens
#9
Ficinine V Ivanovich, Ocmanyan A Karlovich, Reza Mahdavi, Egorov I Afanasyevich
A total of 480 day-old Cobb 500 broilers were used to investigate the effects of different levels of digestible amino acids (DAA; 100%, 107% and 114% of Cobb recommendations) and ME (3,000 or 2,900 kcal/kg) of prestarter diet on mixed sex broilers performance, enzyme activity, small intestine morphology, and serum metabolites. Broilers were randomly allotted to 6 treatments, where each treatment applied to 4 pens with 20 birds in each. The birds were subjected to their respective treatment diets from 1 to 10 days of age...
September 2017: Animal nutrition
https://www.readbyqxmd.com/read/29764450/evaluation-of-target-dose-inhomogeneity-in-breast-cancer-treatment-due-to-tissue-elemental-differences
#10
A Fogliata, F De Rose, A Stravato, G Reggiori, S Tomatis, M Scorsetti, L Cozzi
BACKGROUND: Monte Carlo simulations were run to estimate the dose variations generated by thedifference arising from the chemical composition of the tissues. METHODS: CT datasets of five breast cancer patients were selected. Mammary gland was delineated as clinical target volume CTV, as well as CTV_lob and CTV_fat, being the lobular and fat fractions of the entire mammary gland. Patients were planned for volumetric modulated arc therapy technique, optimized in the Varian Eclipse treatment planning system...
May 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29764038/-expression-and-distribution-of-programmed-death-receptor-1-and-t-cell-immunoglobulin-mucin-3-in-breast-cancer-microenvironment-and-its-relationship-with-clinicopathological-features
#11
H Shen, H Sheng, J J Lu, C Feng, M Yao, H Pan, L S Xu, J F Shen, Y Zheng, Y L Zhou
Objective: To explore the expression and distribution of programmed death receptor 1 (PD-1) and T-cell immunoglobulin mucin 3 (TIM-3) in breast cancer microenvironment and analyze the their correlation with the clinicopathological features. Methods: The specimens of tumor tissue and adjacent tissues from 30 patients with infiltrative breast cancer who were diagnosed as breast cancer from June 2016 to May 2017 in The First Hospital of Jiaxing were collected, and the specimen were divided into two parts along the center...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29762760/evaluation-of-different-dietary-alterations-in-their-ability-to-mitigate-the-incidence-and-severity-of-woody-breast-and-white-striping-in-commercial-male-broilers
#12
B C Bodle, C Alvarado, R B Shirley, Y Mercier, J T Lee
The following study was conducted to define how multiple nutritional strategies affect broiler performance, meat yield, and the presence and severity of white striping (WS) and woody breast (WB) in high-yielding broilers. Relative to a commercial set of reference broiler diets (Commercial reference diet; Trt 1) that were fed in a 4-phase program, the following nutritional strategies were investigated: increasing the ratio of digestible arginine: digestible lysine (dArg: dLys ranged from 113 to 126; Trt 2), supplementing Trt 1 with 94...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29762742/effects-of-reduced-digestible-lysine-density-on-myopathies-of-the-pectoralis-major-muscles-in-broiler-chickens-at-48-and-62-days-of-age
#13
K J Meloche, B I Fancher, D A Emmerson, S F Bilgili, W A Dozier
Quantitative control of nutrient intake may decrease the incidence of wooden breast (WB) and white striping (WS) myopathies with some impairment of live performance. Two experiments (Exp) utilizing Yield Plus × Ross 708 male broilers were conducted to determine if a reduction in myopathies may be obtained through a qualitative approach by reducing digestible lysine (dLys) density. All birds received an identical starter diet until 11 d of age. In Exp 1 (63 pens; 22 birds/pen), each pen was then randomly assigned to 1 of the following 7 dietary treatments (TRT) for a 47 d production period...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29760790/anticancer-properties-of-fenofibrate-a-repurposing-use
#14
REVIEW
Xin Lian, Gang Wang, Honglan Zhou, Zongyu Zheng, Yaowen Fu, Lu Cai
Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little toxicity, fenofibrate is a drug of the fibrate class that plays an important role in lowering the levels of serum cholesterol and triglycerides while elevating the levels of high-density lipoproteins...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29756995/guanidinoacetic-acid-supplementation-in-broiler-chickens-fed-corn-soybean-diets-affects-performance-in-the-finisher-period-and-energy-metabolites-in-breast-muscle-independent-of-diet-nutrient-density
#15
Maryam Majdeddin, Abolghasem Golian, Hassan Kermanshahi, Stefaan De Smet, Joris Michiels
Guanidinoacetic acid (GAA) is the single immediate endogenous precursor of creatine. It was hypothesised that dietary GAA would have different effects on performance and energy metabolites in breast muscle depending on the nutrient density (ND) of corn-soybean based diets. A total of 540 one-day-old male Ross 308 broilers were allocated to nine dietary treatments with six replicates (10 birds each) in a 3 × 3 factorial arrangement with three levels of ND (low, 2800; medium, 2950 and high, 3100 kcal ME/kg; and with the other nutrients being constant relative to ME) and supplemented with three levels of GAA (0, 0...
May 14, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29755845/determination-of-binding-affinity-of-molecular-imaging-agents-for-steroid-hormone-receptors-in-breast-cancer
#16
Kelley Salem, Manoj Kumar, Kyle C Kloepping, Ciara J Michel, Yongjun Yan, Amy M Fowler
16α-[18 F]Fluoro-17β-estradiol ([18 F]FES) and 21-[18 F]-Fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxyl]-19-norpregn-4-ene-3,20-dione ([18 F]FFNP) are being investigated as imaging biomarkers for breast cancer patients. Quantitative positron emission tomography (PET) reflects both total receptor content and binding affinity. To study factors that may alter radiopharmaceutical binding and impact PET accuracy, assays that can separate receptor amount from binding affinity are needed. The study purpose was to quantify the binding parameters of [18 F]FES and [18 F]FFNP in breast cancer...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29754847/feasibility-of-classification-of-triple-negative-breast-cancer-by-immunohistochemical-surrogate-markers
#17
Sewha Kim, Byung-In Moon, Woosung Lim, Sanghui Park, Min Sun Cho, Sun Hee Sung
INTRODUCTION: Recently, Burstein et al identified 4 stable molecular subtypes of triple negative breast cancer (TNBC) by mRNA profiling: luminal androgen receptor (LAR), mesenchymal (MES), basal-like immune-activated (BLIA), and basal-like immune-suppressive (BLIS) types. The purpose of this study was to assess the feasibility of immunohistochemistry (IHC) surrogate panel in classifying the TNBC molecular subtypes using a large cohort of TNBC retrieved from a single institution. MATERIALS AND METHODS: IHC for androgen receptor [AR], claudin-3, E-cadherin, cytokeratin 5/6 [CK5/6], epidermal growth factor receptor [EGFR], indoleamine 2,3-dioxygenase 1 [IDO1], and Forkhead box C1 [FOXC1] were performed using the tissue microarray constructed from 200 TNBC samples...
March 23, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29752687/a-phase-ii-study-evaluating-the-efficacy-of-zoledronic-acid-in-prevention-of-aromatase-inhibitor-associated-musculoskeletal-symptoms-the-zap-trial
#18
Cesar A Santa-Maria, Aditya Bardia, Amanda L Blackford, Claire Snyder, Roisin M Connolly, John H Fetting, Daniel F Hayes, Stacie C Jeter, Robert S Miller, Anne Nguyen, Katie Quinlan, Gary L Rosner, Shannon Slater, Anna Maria Storniolo, Antonio C Wolff, Jane Zorzi, Nora Lynn Henry, Vered Stearns
PURPOSE: Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are common adverse events of AIs often leading to drug discontinuation. We initiated a prospective clinical trial to evaluate whether bisphosphonates are associated with reduced incidence of AIMSS. METHODS: In the single-arm trial, the Zoledronic Acid Prophylaxis (ZAP) trial, we compared the incidence of AIMSS against historical controls from the Exemestane and Letrozole Pharmacogenomics (ELPh) trial...
May 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29748762/predictors-of-surveillance-mammography-outcomes-in-women-with-a-personal-history-of-breast-cancer
#19
Kathryn P Lowry, Lior Z Braunstein, Konstantinos P Economopoulos, Laura Salama, Constance D Lehman, G Scott Gazelle, Elkan F Halpern, Catherine S Giess, Alphonse G Taghian, Janie M Lee
PURPOSE: To identify predictors of poor mammography surveillance outcomes based on clinico-pathologic features. METHODS: This study was HIPAA compliant and IRB approved. We performed an electronic medical record review for a cohort of women with American Joint Committee on Cancer (AJCC) Stage I or II invasive breast cancer treated with breast conservation therapy who developed subsequent in-breast treatment recurrence (IBTR) or contralateral breast cancer (CBC)...
May 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29748047/impact-of-immediate-interpretation-of-screening-tomosynthesis-mammography-on-performance-metrics
#20
Nicole S Winkler, Phoebe Freer, Yoshimi Anzai, Nan Hu, Matthew Stein
RATIONALE AND OBJECTIVES: This study aimed to compare performance metrics for immediate and delayed batch interpretation of screening tomosynthesis mammograms. MATERIALS AND METHODS: This HIPAA compliant study was approved by institutional review board with a waiver of consent. A retrospective analysis of screening performance metrics for tomosynthesis mammograms interpreted in 2015 when mammograms were read immediately was compared to historical controls from 2013 to 2014 when mammograms were batch interpreted after the patient had departed...
May 7, 2018: Academic Radiology
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