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https://www.readbyqxmd.com/read/28551479/dna-and-protein-binding-double-strand-dna-cleavage-and-cytotoxicity-of-mixed-ligand-copper-ii-complexes-of-the-antibacterial-drug-nalidixic-acid
#1
Rangasamy Loganathan, Mani Ganeshpandian, Nattamai S P Bhuvanesh, Mallayan Palaniandavar, Amsaveni Muruganantham, Swapan K Ghosh, Anvarbatcha Riyasdeen, Mohammad Abdulkader Akbarsha
The water soluble mixed ligand complexes [Cu(nal)(diimine)(H2O)](ClO4) 1-4, where H(nal) is nalidixic acid and diimine is 2,2'-bipyridine (1), 1,10-phenanthroline (2), 5,6-dimethyl-1,10-phenanthroline (3), and 3,4,7,8-tetramethyl-1,10-phenanthroline (4), have been isolated. The coordination geometry around Cu(II) in 1 and that in the Density Functional Theory optimized structures of 1-4 has been assessed as square pyramidal. The trend in DNA binding constants (Kb) determined using absorption spectral titration (Kb: 1, 0...
May 3, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28550909/readability-complexity-and-suitability-of-online-resources-for-mastectomy-and-lumpectomy
#2
Bao Ngoc N Tran, Mansher Singh, Dhruv Singhal, Rima Rudd, Bernard T Lee
BACKGROUND: Nearly half of American adults have low or marginal health literacy. This negatively affects patients' participation, decision-making, satisfaction, and overall outcomes especially when there is a mismatch between information provided and the skills of the intended audience. Recommendations that patient information be written below the sixth grade level have been made for over three decades. This study compares online resources for mastectomy versus lumpectomy using expanded metrics including readability level, complexity, and density of data and overall suitability for public consumption...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550626/combination-breast-cancer-chemotherapy-with-doxorubicin-and-cyclophosphamide-damages-bone-and-bone-marrow-in-a-female-rat-model
#3
Chiaming Fan, Kristen R Georgiou, Howard A Morris, Ross A McKinnon, Dorothy M K Keefe, Peter R Howe, Cory J Xian
PURPOSE: Anthracyclines (including doxorubicin) are still the backbone of commonly used breast cancer chemotherapy regimens. Despite increasing use of doxorubicin and cyclophosphamide (AC) combinations for treating breast cancer, their potential to cause adverse skeletal effects remains unclear. METHODS: This study examined the effects of treatments with the AC regimen on bone and bone marrow in adult female rats. RESULTS: AC treatment for four cycles (weekly intravenous injection of 2 mg/kg doxorubicin and 20 mg/kg cyclophosphamide) resulted in a reduced volume of trabecular bone at the metaphysis, which was associated with reduced serum levels of 25-hydroxy vitamin D3 and alkaline phosphatase...
May 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28550173/experimental-cardiac-radiation-exposure-induces-ventricular-diastolic-dysfunction-with-preserved-ejection-fraction
#4
Hirofumi Saiki, Gilles Moulay, Adam J Guenzel, Weibin Liu, Teresa Decklever, Kelly Classic, Linh Pham, Horng H Chen, John C Burnett, Stephen J Russell, Margaret M Redfield
BACKGROUND: Breast cancer radiotherapy increases the risk of heart failure (HF) with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radio-resistant but radiation specifically affects coronary microvascular endothelial cells with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28545469/age-related-terminal-duct-lobular-unit-involution-in-benign-tissues-from-chinese-breast-cancer-patients-with-luminal-and-triple-negative-tumors
#5
Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D Figueroa, Mark E Sherman, Gretchen L Gierach, Ning Lu, Xiaohong R Yang
BACKGROUND: Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, researchers have found that age-matched women with lower levels of TDLU involution are at increased risk of developing breast cancer. We previously showed that breast cancer cases with core basal phenotype (CBP; estrogen receptor negative [ER(-)], progesterone receptor-negative [PR(-)], human epidermal growth factor receptor 2-negative [HER2(-)], cytokeratins (CK 5 or CK5/6)-positive [CK5/6(+)] and/or epidermal growth factor receptor-positive [EGFR(+)]) tumors had significantly reduced TDLU involution compared with cases with luminal A (ER(+) and/or PR(+), HER2(-), CK5/6(-), EGFR(-)) tumors from a population-based case-control study in Poland...
May 25, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28545182/breast-cancer-in-australian-indigenous-women-incidence-mortality-and-risk-factors
#6
Kriscia A Tapia, Gail Garvey, Mark Mc Entee, Mary Rickard, Patrick Brennan
The Indigenous people of Australia face significant health gaps compared with the general population, with lower life expectancies, higher rates of death, and chronic illness occurring more often than in non-indigenous Australians. Cancer is the second largest contributor to the burden of disease with breast cancer being the most common invasive cancer diagnosed for females. Despite a lower breast cancer incidence compared with non-indigenous women, fatalities occur at an elevated rate and breast cancers have an earlier age of onset...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28542558/improvement-of-non-key-traits-in-radiata-pine-breeding-programme-when-long-term-economic-importance-is-uncertain
#7
Yongjun Li, Heidi Dungey, Alvin Yanchuk, Luis A Apiolaza
Diameter at breast height (DBH), wood density (DEN) and predicted modulus of elasticity (PME) are considered as 'key traits' (KT) in the improvement in radiata pine breeding programmes in New Zealand. Any other traits which are also of interest to radiata pine breeders and forest growers are called 'non-key traits' (NKTs). External resin bleeding (ERB), internal checking (IC), number of heartwood rings (NHR) are three such non-key traits which affect wood quality of radiata pine timber. Economic importance of the KTs and NKTs is hard to define in radiata pine breeding programmes due to long rotation period...
2017: PloS One
https://www.readbyqxmd.com/read/28535623/-the-breast-cancer-diagnosis-accuracy-of-the-digital-breast-tomosynthesis-technique
#8
H W Zhang, J T Li, M H Lü, L Qin, L F Li, S D Cui, H Liu
Objective: To explore the Digital breast tomosynthesis technique (DBT) in breast cancer diagnosis accuracy. Methods: Choose 263 cases of patients with breast lesions, using DBT combined FFDM (Full field digital mammography) independent FFDM, evaluate the diagnostic accuracy of breast cancer. Results: The ROC curve area (AUC) of two kinds of breast cancer diagnosis methods (DBT combined FFDM and independent FFDM) were 0.954±0.014 and 0.907±0.019, with significant difference (P=0.000 3). In premenopausal patients and breast density ACR3-4 cases, DBT combined FFDM diagnosis accuracy is higher than FFDM alone group, with significant difference (P<0...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28533703/differential-expression-of-vegfr2-protein-in-her2-positive-primary-human-breast-cancer-potential-relevance-to-anti-angiogenic-therapies
#9
Aejaz Nasir, Timothy R Holzer, Mia Chen, Michael Z Man, Andrew E Schade
BACKGROUND: Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to breast cancer (BRC) patient subpopulations are an unmet need. METHODS: We analyzed tumor vascular density and VEGFR2 protein expression in various subsets of primary human BRCs (186 females; Mean age: 59 years; range 33-88 years), using a tissue microarray. Discrete VEGFR2+ and CD34+ tumor vessels were manually scored in invasive ductal, lobular, mixed ductal-lobular and colloid (N = 139, 22, 18, 7) BRC cores...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28528800/an-innovative-method-of-planning-and-displaying-flap-volume-in-diep-flap-breast-reconstructions
#10
S Hummelink, Arico C Verhulst, Thomas J J Maal, Yvonne L Hoogeveen, Leo J Schultze Kool, Dietmar J O Ulrich
BACKGROUND: Determining the ideal volume of the harvested flap to achieve symmetry in deep inferior epigastric artery perforator (DIEP) flap breast reconstructions is complex. With preoperative imaging techniques such as 3D stereophotogrammetry and computed tomography angiography (CTA) available nowadays, we can combine information to preoperatively plan the optimal flap volume to be harvested. In this proof-of-concept, we investigated whether projection of a virtual flap planning onto the patient's abdomen using a projection method could result in harvesting the correct flap volume...
April 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28527821/impact-of-sodium-bicarbonate-buffered-lidocaine-on-patient-pain-during-image-guided-breast-biopsy
#11
Alison Vasan, Jay A Baker, Rebecca A Shelby, Mary Scott C Soo
PURPOSE: This randomized, double-blind controlled study evaluated the effectiveness of sodium bicarbonate-buffered lidocaine on reducing pain during imaging-guided breast biopsies. MATERIALS AND METHODS: This prospective, HIPAA-compliant study randomly assigned 85 women undergoing ultrasound- or stereotactic-guided core-needle breast biopsies to receive intradermally and intraparenchymally either 1% lidocaine buffered with sodium bicarbonate (9:1 ratio) (bicarbonate study group) or 1% lidocaine alone (control group)...
May 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28526892/stereotactic-core-needle-breast-biopsy-marker-migration-an-analysis-of-factors-contributing-to-immediate-marker-migration
#12
Ashali Jain, Maria Khalid, Muhammad M Qureshi, Dianne Georgian-Smith, Jonah A Kaplan, Karen Buch, Mark W Grinstaff, Ariel E Hirsch, Neely L Hines, Stephan W Anderson, Katherine M Gallagher, David D B Bates, B Nicolas Bloch
OBJECTIVES: To evaluate breast biopsy marker migration in stereotactic core needle biopsy procedures and identify contributing factors. METHODS: This retrospective study analyzed 268 stereotactic biopsy markers placed in 263 consecutive patients undergoing stereotactic biopsies using 9G vacuum-assisted devices from August 2010-July 2013. Mammograms were reviewed and factors contributing to marker migration were evaluated. Basic descriptive statistics were calculated and comparisons were performed based on radiographically-confirmed marker migration...
May 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28526378/association-between-prepregnancy-obesity-and-metabolic-risk-in-chilean-premenopausal-women-10%C3%A2-y-postpartum
#13
Maria Luisa Garmendia, Carolina Zamudio, Marcela Araya, Juliana Kain
OBJECTIVES: One of every four pregnant women in Chile is obese. Gestational obesity is associated with maternal metabolic complications in pregnancy (e.g., gestational diabetes, preeclampsia), but to our knowledge, there is little evidence on relationships with future metabolic risk. The aim of this study was to evaluate the association between prepregnancy obesity (prepregnancy body mass index ≥30 kg/m(2)) or excessive gestational weight gain (GWG; according to the 2009 recommendations from the Institute of Medicine), and maternal metabolic complications 10 y postpartum in premenopausal Chilean women...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28525534/lymphocyte-density-determined-by-computational-pathology-validated-as-a-predictor-of-response-to-neoadjuvant-chemotherapy-in-breast-cancer-secondary-analysis-of-the-artemis-trial
#14
H R Ali, A Dariush, J Thomas, E Provenzano, J Dunn, L Hiller, A-L Vallier, J Abraham, T Piper, J M S Bartlett, D A Cameron, L Hayward, J D Brenton, P D P Pharoah, M Irwin, N A Walton, H M Earl, C Caldas
Background: HASH(0x356e448) Patients and methods: HASH(0x356dfb0) Results: HASH(0x35279d0) Conclusions: HASH(0x3523980)
May 19, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28523945/prevention-of-postmenopausal-osteoporosis-in-chinese-women-a-5-year-double-blind-randomized-parallel-placebo-controlled-study
#15
S Y Ran, Q Yu, Y Chen, S Q Lin
OBJECTIVES: To observe the effectiveness and safety of menopause-related hormone therapy (MHT) to prevent bone loss in Chinese women during the menopausal transition and early menopause, as well as to evaluate the effects of 5-year MHT on overall health to add Level I evidence for the prevention of osteoporosis using MHT. DESIGN: This clinical study was a prospective, double-blind, randomized, parallel placebo-controlled study. Chinese women in the menopausal transition and early menopause were randomly allocated to the MHT group or the placebo group...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28521812/radiotherapy-improves-serum-fatty-acids-and-lipid-profile-in-breast-cancer
#16
Sana Shaikh, Naseem Aslam Channa, Farha Naz Talpur, Muhammad Younis, Naila Tabassum
BACKGROUND: Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer. METHODS: In this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile...
May 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28516070/bone-density-in-postmenopausal-women-with-or-without-breast-arterial-calcification
#17
Atoosa Adibi, Farnaz Rabani, Silva Hovsepian
BACKGROUND: Identification of osteoporosis in women in order to prevent its related morbidity and mortality is considered a priority. Routine mammography is performed on all menopausal women as a screening tool. Determination of the relation between breast arterial calcification (BAC) on mammography and the bone density of this high-risk population could help us to determine those with osteoporosis. The aim of this study was to investigate the mentioned probable relation between BAC and osteoporosis...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28515107/a-randomized-double-blind-placebo-controlled-trial-of-the-effect-of-vitamin-d3-supplementation-on-breast-density-in-premenopausal-women
#18
Jacques Brisson, Sylvie Bérubé, Caroline Diorio, Benoit Masse, Julie Lemieux, Thierry Duchesne, Edgar Delvin, Reinhold Vieth, Martin J Yaffe, Jocelyne Chiquette
BACKGROUND: This double-blind, placebo-controlled parallel-group trial assessed whether oral supplementation with 1,000, 2,000 or 3,000 IU/day vitamin D3 over one year reduces percent mammographic breast density in premenopausal women. METHODS: The trial was conducted between October 2012 and June 2015, among premenopausal female volunteers from Quebec City (Quebec, Canada). Women were randomized with ratio 1:1:1:1 to one of four study arms (1,000, 2,000 or 3,000 IU/d vitamin D3 or placebo)...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28514957/high-lymphatic-vessel-density-and-presence-of-lymphovascular-invasion-both-predict-poor-prognosis-in-breast-cancer
#19
Song Zhang, Dong Zhang, Mingfu Gong, Li Wen, Cuiwei Liao, Liguang Zou
BACKGROUND: Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients' survival are still uncertain. METHODS: Databases of PubMed, Embase, and Web of Science were searched from inception up to 30 June 2016. The hazard ratio with its 95% confidence interval was used to determine the prognostic effects of lymphatic vessel density and lymphovascular invasion on disease-free survival and overall survival in breast cancer...
May 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28512246/tumor-associated-macrophages-promote-malignant-progression-of-breast-phyllodes-tumors-by-inducing-myofibroblast-differentiation
#20
Yan Nie, Jia-Ning Chen, Di Huang, Yandan Yao, Jiewen Chen, Lin Ding, Jiayi Zeng, Shicheng Su, Xue Chao, Fengxi Su, Herui Yao, Hai Hu, Erwei Song
Myofibroblast differentiation plays an important role in the malignant progression of phyllodes tumor (PT), a fast-growing neoplasm derived from periductal stromal cells of the breast. Macrophages are frequently found in close proximity with myofibroblasts, but it is uncertain whether they are involved in the myofibroblast differentiation during PT progression. Here we show that increased density of tumor associated macrophage (TAM) correlates with malignant progression of PT. We found that TAM stimulated myofibroblast differentiation and promoted the proliferation and invasion of PT cells...
May 16, 2017: Cancer Research
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