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https://www.readbyqxmd.com/read/29679706/an-elemental-impurities-excipient-database-a-viable-tool-for-ich-q3d-drug-product-risk-assessment
#1
Ruth Boetzel, Agnieszka Ceszlak, Christopher Day, Patrick Drumm, Joan Gil Bejar, John Glennon, Laurence Harris, Crina I Heghes, Radu Horga, Peter L Jacobs, Wilfried J T M Keurentjes, Fiona King, Carlos W Lee, Nancy Lewen, Carol A Marchant, Frans A Maris, William Nye, Samuel Powell, Helmut Rockstroh, Laura Rutter, Mark Schweitzer, Elaine Shannon, Lance Smallshaw, Andrew Teasdale, Sarah Thompson, David Wilkinson
To support the practical implementation of the ICH Q3D guideline, which describes a risk-based approach to the control of elemental impurities in drug products, a consortium of pharmaceutical companies has established a database to collate the results of analytical studies of the levels of elemental impurities within pharmaceutical excipients. This database currently includes the results of 26723 elemental determinations for 201 excipients and represents the largest known, and still rapidly expanding, collection of data of this type...
April 18, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29679434/key-issues-to-consider-and-innovative-ideas-on-fall-prevention-in-the-geriatric-department-of-a-teaching-hospital
#2
Daniel Ky Chan, Cathie Sherrington, Vasi Naganathan, Ying Hua Xu, Jack Chen, Anita Ko, Ian Kneebone, Robert Cumming
Falls in hospital are common and up to 70% result in injury, leading to increased length of stay and accounting for 10% of patient safety-related deaths. Yet, high-quality evidence guiding best practice is lacking. Fall prevention strategies have worked in some trials but not in others. Differences in study setting (acute, subacute, rehabilitation) and sampling of patients (cognitively intact or impaired) may explain the difference in results. This article discusses these important issues and describes the strategies to prevent falls in the acute hospital setting we have studied, which engage the cognitively impaired who are more likely to fall...
April 20, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29678714/transmuscle-ultrasonography-in-the-placement-of-thoracolumbar-pedicle-screws-a-cadaveric-study
#3
Cheng-Long Xie, Qi-Shan Huang, Long Wu, Lei Xu, Hai-Cheng Dou, Xiang-Yang Wang, Zhong-Ke Lin
BACKGROUND: Transpedicular screws fixation has a biomechanical advantage of improving fusion rates. In the posterior thoracolumbar immobilization, a large number of screws cause perforation to pedicle or vertebra body. Techniques as radiograph and CT were used to minimize this complication. However, ultrasound in detecting the pedicle breach during the placement of the screw in unknown. Our goal is to evaluate the sensitivity of ultrasound for detecting the breaches. METHODS: A B-type transducer was used for scanning 216 Titanium pins inserted into the cadaveric pedicle...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678013/implementation-of-a-new-traceability-process-for-breast-milk-feeding
#4
Mariana Y Daus, Thelma G Maydana, Daniel A Rizzato Lede, Daniel R Luna
Many newborns at the neonatal intensive care unit are unable to feed themselves, and receive human milk through enteric nutrition devices such as orogastric or nasogastric probes. The mothers extract their milk, and the nursing staff is responsible for the fractionation, storage and administration when prescribed by physicians. It is very important to remind that it is a bodily fluid that carries the risk of disease transmission if misused. Health information technologies can enhance patient safety by avoiding preventable adverse events...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677980/a-method-for-developing-standard-patient-education-program
#5
Carolina Bryne Lura, Sophie Misser Pallesgaard Hauch, Kirstine Rosenbeck Gøeg, Louise Pape-Haugaard
In Denmark, patients being treated on Haematology Outpatients Departments get instructed to self-manage their blood sample collection from Central Venous Catheter (CVC). However, this is a complex and risky procedure, which can jeopardize patient safety. The aim of the study was to suggest a method for developing standard digital patient education programs for patients in self-administration of blood samples drawn from CVC. The Design Science Research Paradigm was used to develop a digital patient education program, called PAVIOSY, to increase patient safety during execution of the blood sample collection procedure by using videos for teaching as well as procedural support...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677974/enhancing-safety-of-artificially-ventilated-patients-using-ambient-process-analysis
#6
Christian Lins, Alexander Gerka, Christian Lüpkes, Rainer Röhrig, Andreas Hein
In this paper, we present an approach for enhancing the safety of artificially ventilated patients using ambient process analysis. We propose to use an analysis system consisting of low-cost ambient sensors such as power sensor, RGB-D sensor, passage detector, and matrix infrared temperature sensor to reduce risks for artificially ventilated patients in both home and clinical environments. We describe the system concept and our implementation and show how the system can contribute to patient safety.
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677922/implementing-an-antibiotic-stewardship-information-system-to-improve-hospital-infection-control-a-co-design-process
#7
Mélanie R Maia, Alexandra Simões, Luís V Lapão
HAITooL information system design and implementation was based on Design Science Research Methodology, ensuring full participation, in close collaboration, of researchers and a multidisciplinary team of healthcare professionals. HAITooL enables effective monitoring of antibiotic resistance, antibiotic use and provides an antibiotic prescription decision-supporting system by clinicians, strengthening the patient safety procedures. The design, development and implementation process reveals benefits in organizational and behavior change with significant success...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677580/effects-of-a-skill-demonstration-video-delivered-by-smartphone-on-facilitating-nursing-students-skill-competencies-and-self-confidence-a-randomized-controlled-trial-study
#8
Yeu-Hui Chuang, Fu-Chih Lai, Chia-Chi Chang, Hsu-Tien Wan
BACKGROUND: The correct and appropriate performance of nursing skills by students can ensure patient safety and care quality. However, developing appropriate teaching and learning strategies to enhance nursing students' nursing skills and knowledge are challenging tasks for nursing faculty members. Nowadays, smartphones are popular mobile devices that are used on campuses by students and could be considered a potential tool to deliver learning materials to nursing students. OBJECTIVES: This study aimed to examine the effects of a skill demonstration video delivered by smartphone on facilitating nursing students' nursing skill competency and confidence...
April 7, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29676186/it-takes-one-to-know-one-exploring-patient-dialogue-on-rosacea-web-based-platforms-and-their-potential-for-significant-harm
#9
Laura H Riddoch
BACKGROUND: Rosacea is a non-curable skin condition, leading patients to turn self-management options from web based platforms. Self-management can be dangerous possibly under-reported. AIM: To discover the extent of online material and determine the potential for harm influenced by rosacea internet sources. MATERIALS AND METHODS: Material analysed included search engines, apps, YouTube, forums and Facebook groups. As Facebook and forums were most active, they became the core focus...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29675898/implementation-of-the-who-surgical-safety-checklist-at-a-teaching-hospital-in-india-and-evaluation-of-the-effects-on-perioperative-complications
#10
Raghavendra Shankar
BACKGROUND: The WHO Surgical Safety Checklist was developed to help operating teams reduce the occurrence of patient harm. The Checklist is a simple, practical tool that any surgical team in the world can use to ensure that the preoperative, intraoperative, and postoperative steps that have been shown to benefit patients are undertaken in a timely and efficient way. METHODS: This study was carried out at Rajarajeswari Medical College Hospital, Bangalore, India, to study the effects of the WHO Surgical Safety Checklist on mortality and morbidity in surgical patients, to identify the potential problems in the long-term implementation of the same, and to document the complications in patients undergoing a major surgery during the study period...
April 20, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29675679/adsorption-and-leachable-contamination-of-flucloxacillin-cyclosporin-and-amiodarone-following-delivery-through-an-intravenous-administration-set
#11
Zachary Woodward, Peter Brooks, Bernadette Morris-Smith, Marianne Wallis, Steven M Ogbourne
PURPOSE: Interactions between a pharmaceutical drug and its delivery device can result in changes in drug concentration and leachable contamination. Flucloxacillin, amiodarone and cyclosporin were investigated for drug concentration changes and leachable contamination after delivery through an intravenous administration set. METHODS: Flucloxacillin, amiodarone and cyclosporin were delivered through an intravenous administration set and the eluate analysed by HPLC-UV and HPLC-MS...
April 19, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29674511/how-do-i-raise-patient-safety-concerns-and-when-does-this-become-whistleblowing
#12
Abi Rimmer
No abstract text is available yet for this article.
April 19, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29674327/incorporating-medication-indications-into-the-prescribing-process
#13
Kevin Kron, Sara Myers, Lynn Volk, Aaron Nathan, Pamela Neri, Alejandra Salazar, Mary G Amato, Adam Wright, Sam Karmiy, Sarah McCord, Enrique Seoane-Vazquez, Tewodros Eguale, Rosa Rodriguez-Monguio, David W Bates, Gordon Schiff
PURPOSE: The incorporation of medication indications into the prescribing process to improve patient safety is discussed. SUMMARY: Currently, most prescriptions lack a key piece of information needed for safe medication use: the patient-specific drug indication. Integrating indications could pave the way for safer prescribing in multiple ways, including avoiding look-alike/sound-alike errors, facilitating selection of drugs of choice, aiding in communication among the healthcare team, bolstering patient understanding and adherence, and organizing medication lists to facilitate medication reconciliation...
April 19, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29673802/-assessment-of-the-severity-of-postoperative-complications-from-the-patient-and-doctor-perspective
#14
Anja Klingenberg, Stefan Nöst, Joachim Szecsenyi
AIM OF THE STUDY: This study compares doctors' and patients' assessments of the severity of postoperative complications reported by patients. Within the context of quality assurance and patient safety, the study aims to contribute to developing instruments to include patients' views for measuring postoperative complications. METHODS: In a questionnaire development study 474 patients who had undergone different kinds of surgery were given a questionnaire and asked whether postoperative complications occurred, and if so, to describe these complications in free text and to assesses their severity as "slight, temporary" or "extensive"...
April 16, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29672577/the-contribution-of-open-comments-to-understanding-the-results-from-the-hospital-survey-on-patient-safety-culture-hsops-a-qualitative-study
#15
Bastien Boussat, Kevin Kamalanavin, Patrice François
INTRODUCTION: To develop high-quality and safe healthcare, a good safety culture is an important feature of healthcare-providing structures. The objective of this study was to analyze the qualitative data of the comments section of a Hospital Survey on Patient Safety (HSOPS) questionnaire to clarify the answers given to the closed questions. METHOD: Using the original data from a cross-sectional survey of 5,064 employees at a single university hospital in France, we conducted a qualitative study by analyzing the comments of a HSOPS survey and conducting in-depth interviews with 19 healthcare providers...
2018: PloS One
https://www.readbyqxmd.com/read/29672526/structured-patient-handoff-on-an-internal-medicine-ward-a-cluster-randomized-control-trial
#16
Penny Tam, Aman P Nijjar, Mark Fok, Chris Little, Alexandra Shingina, Jesse Bittman, Rashmi Raghavan, Nadia A Khan
BACKGROUND: The effect of a multi-faceted handoff strategy in a high volume internal medicine inpatient setting on process and patient outcomes has not been clearly established. We set out to determine if a multi-faceted handoff intervention consisting of education, standardized handoff procedures, including fixed time and location for face-to-face handoff would result in improved rates of handoff compared with usual practice. We also evaluated resident satisfaction, health resource utilization and clinical outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29672420/the-arrival-of-robotics-in-spine-surgery-a-review-of-the-literature
#17
Alexander Ghasem, Akhil Sharma, Dylan N Greif, Milad Alam, Motasem Al Maaieh
STUDY DESIGN: Systematic Review. OBJECTIVE: The authors aim to review comparative outcome measures between robotic and free-hand spine surgical procedures including: accuracy of spinal instrumentation, radiation exposure, operative time, hospital stay, and complication rates. SUMMARY OF BACKGROUND DATA: Misplacement of pedicle screws in conventional open as well as minimally invasive surgical procedures has prompted the need for innovation and allowed the emergence of robotics in spine surgery...
April 18, 2018: Spine
https://www.readbyqxmd.com/read/29672374/integrating-team-training-in-the-pediatric-life-support-program-an-effective-and-efficient-approach
#18
Mary J Fagan, Cynthia D Connelly, Brian S Williams, Erin Stucky Fisher
OBJECTIVE: The aim of this study was to examine the feasibility of integrating teamwork training into an established Pediatric Advanced Life Support (PALS) program to assess the effect on teamwork and collaboration among interprofessionals. BACKGROUND: Lack of teamwork and ineffective communication are common contributors to hospital sentinel events. Interprofessional teamwork training to support a culture of patient safety is advocated; however, training methods and related expenses vary widely...
May 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29670992/promotion-of-hand-hygiene-the-experience-of-the-orthopaedic-hospital-gaetano-pini-cto-milan-italy
#19
M Nobile, C Conti, A Bastianelli, A Piscitelli, G M Calori, P Navone
BACKGROUND: Hand hygiene is the primary preventive measure against health care-associated infections in terms of cost-effectiveness. In 2005, the WHO proposed the "Global Patient Safety Challenge" campaign, with the aim of reducing the overall incidence of such infections, through multimodal programs and strategies, interactive training tools and standardised methods for monitoring compliance. STUDY DESIGN: On the basis of project "Rimani", sponsored by the Health and Social Care Authority of Emilia-Romagna, the Istituto Ortopedico Gaetano Pini has implemented a project which seeks to increase healthcare staff's compliance with hand hygiene...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29669706/reasons-for-physicians-not-adopting-clinical-decision-support-systems-critical-analysis
#20
REVIEW
Saif Khairat, David Marc, William Crosby, Ali Al Sanousi
BACKGROUND: Clinical decision support systems (CDSSs) are an integral component of today's health information technologies. They assist with interpretation, diagnosis, and treatment. A CDSS can be embedded throughout the patient safety continuum providing reminders, recommendations, and alerts to health care providers. Although CDSSs have been shown to reduce medical errors and improve patient outcomes, they have fallen short of their full potential. User acceptance has been identified as one of the potential reasons for this shortfall...
April 18, 2018: JMIR Medical Informatics
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