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https://www.readbyqxmd.com/read/29677638/gestational-glucocorticoid-exposure-disrupts-glucose-homeostasis-that-is-accompanied-by-increased-endoglin-and-dpp-4-activity-instead-of-gsk-3-in-rats
#1
Olufunto O Badmus, Olugbenga S Michael, Saheed Rabiu, Lawrence A Olatunji
Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring's in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflammatory biomarkers, DPP-4 activity and GSK-3 in pregnant rats. Pregnant Wistar rats received either vehicle or dexamethasone (DEX; 0...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677535/betulinic-acid-attenuates-dexamethasone-induced-oxidative-damage-through-the-jnk-p38-mapk-signaling-pathway-in-mice
#2
Lijuan Zhu, Xianglian Yi, Jing Zhao, Zhihang Yuan, Lixin Wen, Blazej Pozniak, Bozena Obminska-Mrukowicz, Yanan Tian, Zhuliang Tan, Jing Wu, Jine Yi
Dexamethasone (Dex), a potent anti-inflammatory/immunosuppressive agent, has been shown to induce oxidative stress. Betulinic acid (BA) is a pentacyclic lupane triterpene with a potent antioxidant activity. The aim of this study was to investigate the ameliorative effect and underlying mechanisms of BA on Dex-induced oxidative damage. Mice were pretreated with BA orally (0, 0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and then a single dose of Dex (25 mg/kg body weight) was administered intraperitoneally 8 h after the last administration of BA to induce oxidative stress...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676440/an-effective-modestly-intensive-re-induction-regimen-with-bortezomib-in-relapsed-or-refractory-paediatric-acute-lymphoblastic-leukaemia
#3
Gertjan J L Kaspers, Denise Niewerth, Bram A J Wilhelm, Peggy Scholte-van Houtem, Marta Lopez-Yurda, Johannes Berkhof, Jacqueline Cloos, Valerie de Haas, Ron A Mathôt, Andishe Attarbaschi, André Baruchel, Eveline S de Bont, Franca Fagioli, Claudia Rössig, Thomas Klingebiel, Barbara De Moerloose, Brigitte Nelken, Giuseppe Palumbo, Dirk Reinhardt, Pierre-Simon Rohrlich, Pauline Simon, Arend von Stackelberg, Michel M Zwaan
This trial explored the efficacy of re-induction chemotherapy including bortezomib in paediatric relapsed/refractory acute lymphoblastic leukaemia. Patients were randomized 1:1 to bortezomib (1.3 mg/m2 /dose) administered early or late to a dexamethasone and vincristine backbone. Both groups did not differ regarding peripheral blast count on day 8, the primary endpoint. After cycle 1, 8 of 25 (32%) patients achieved complete remission with incomplete blood count recovery, 7 (28%) a partial remission and 10 had treatment failure...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29676131/-jatrorrhizine-regulates-gluts-with-multiple-manners-for-hypoglycemic-effect-in-insulin-resistance-3t3-l1-adipocytes
#4
Shui-Lan Zhu, Ting Lei, Xu Gao, Jun Tu
This paper aimed to investigate the hypoglycemic effect and relative mechanism of jatrorrhizine in insulin-resistance (IR)-3T3-L1 adipocytes. The 3T3-L1 preadipocytes were used to induce mature adipocytes, then the stable IR model was established with 1 μmol·L⁻¹ dexamethasone. The adipocytes were divided into normal group, IR model group, rosiglitazone positive group and jatrorrhizine group (0.5, 1, 5, 10, 20 μmol·L⁻¹). After different time points (12, 24, 30, 36, 48 h) treatment, glucose content of 3T3-L1 adipocytes was detected by the glucose oxidase peroxidase method and TG content was measured by glycerol phosphate oxidase method, whereas cell viability was detected by CCK-8 assay...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675725/effect-of-pycnogenol%C3%A2-on-an-experimental-rat-model-of-allergic-conjunctivitis
#5
Ayse Ipek Akyuz Unsal, Tolga Kocaturk, Ceren Gunel, Ibrahim Meteoglu, Imran Kurt Omurlu, Harun Cakmak, Buket Demirci
BACKGROUND: Allergic conjunctivitis (AC) is a frequent and challenging disease in ophthalmology practice. Cell protective effect of Pycnogenol® (PYC) depends on its antioxidant and anti-inflammatory properties. The aim of the study is to investigate the effect of PYC on an experimental AC model. METHODS: Ovalbumin and Al(OH)3 were given seven times intraperitoneally (i.p.) every other day and ovalbumin installed everyday directly on conjunctiva to create an AC rat model...
April 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29675437/-punica-granatum-l-leaf-extract-attenuates-lung-inflammation-in-mice-with-acute-lung-injury
#6
Aruanã Joaquim Matheus Costa Rodrigues Pinheiro, Jaciara Sá Gonçalves, Ádylla Wilenna Alves Dourado, Eduardo Martins de Sousa, Natilene Mesquita Brito, Lanna Karinny Silva, Marisa Cristina Aranha Batista, Joicy Cortez de Sá, Cinara Regina Aragão Vieira Monteiro, Elizabeth Soares Fernandes, Valério Monteiro-Neto, Lee Ann Campbell, Patrícia Maria Wiziack Zago, Lidio Gonçalves Lima-Neto
The hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegranate leaf hydroalcoholic extract (EAFPg) on the LPS-induced acute lung injury (ALI) mouse model. Male Swiss mice received either EAFPg at different doses or dexamethasone (per os) prior to LPS intranasal instillation...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29675373/comparison-of-the-effects-of-intravitreal-bevacizumab-and-dexamethasone-in-experimental-posterior-penetrating-eye-injury
#7
Ayse Oner, Nisa Kahraman, Saim Ozdamar, Esra Balcioglu
AIM: To compare the effects of intravitreal anti-vascular endothelial growth factor (VEGF) and dexamethasone in an experimental rabbit model of posterior penetrating ocular injury. METHODS: Thirty white New Zealand rabbits were included in the study. A posterior penetrating ocular injury was performed at the superotemporal quadrant. They were randomly divided into three groups. The rabbits in group 1 received intravitreal dexamethasone, in group 2 they received intravitreal bevacizumab and those in group 3 received intravitreal physiological saline solution in both eyes...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674771/high-dose-dexamethasone-therapy-as-the-initial-treatment-for-idiopathic-thrombocytopenic-purpura-protocol-for-a-multicenter-open-label-single-arm-trial
#8
Ken Takase, Akiko Kada, Hiromi Iwasaki, Isao Yoshida, Morio Sawamura, Nobuyuki Yoshio, Shinichiro Yoshida, Hiroatsu Iida, Maki Otsuka, Toshiro Takafuta, Yuko Ogata, Youko Suehiro, Yukio Hirabayashi, Terutoshi Hishita, Chikamasa Yoshida, Takuo Ito, Michihiro Hidaka, Ikuyo Tsutsumi, Akiko M Saito, Hirokazu Nagai
Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of <20, 000 /μL, or with <50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674503/dexamethasone-promotes-durable-factor-viii-specific-tolerance-in-hemophilia-a-mice-via-thymic-mechanisms
#9
Maria T Georgescu, Paul C Moorehead, Alice S van Velzen, Kate Nesbitt, Birgit M Reipert, Katharina N Steinitz, Maria Schuster, Christine Hough, David Lillicrap
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avoidance of factor VIII exposure during innate immune system activation by external stimuli (e.g. vaccines) has not been consistently shown to prevent inhibitors. We hypothesized that dexamethasone, a drug with potent anti-inflammatory effects, could prevent inhibitors by promoting immunologic tolerance to factor VIII in hemophilia A mice...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674494/safety-and-efficacy-of-vorinostat-bortezomib-doxorubicin-and-dexamethasone-in-a-phase-i-ii-study-for-relapsed-or-refractory-multiple-myeloma-verumm-study-vorinostat-in-elderly-relapsed-and-unfit-multiple-myeloma
#10
Johannes M Waldschmidt, Alexander Keller, Gabriele Ihorst, Olga Grishina, Stefan Müller, Dagmar Wider, Anna V Frey, Kristina King, Roman Simon, Annette May, Pierfrancesco Tassone, Justus Duyster, Manfred Jung, Noopur Raje, Ralph Wäsch, Monika Engelhardt
This phase I/II trial was conducted to investigate the safety, efficacy, and pharmacodynamics of the pan-HDAC-inhibitor (HDACi) vorinostat combined with bortezomib, doxorubicin, and dexamethasone (VBDD) in patients suffering from relapsed/refractory multiple myeloma (RRMM). In the phase I part of this study, 9/33 patients received dose-escalated vorinostat (100, 200, 300mg), using a 4-day-on and 4-day-off schedule, and a standard 3+3 design. In the phase II part of the study, 24/33 patients were included to further assess VBDD's safety and efficacy...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674440/lenalidomide-in-pretreated-mantle-cell-lymphoma-patients-an-italian-observational-multicenter-retrospective-study-in-daily-clinical-practice-the-lenamant-study
#11
Vittorio Stefoni, Cinzia Pellegrini, Alessandro Broccoli, Luca Baldini, Monica Tani, Emanuele Cencini, Amalia Figuera, Michela Ansuinelli, Elisa Bernocco, Maria Cantonetti, Maria Christina Cox, Filippo Ballerini, Chiara Rusconi, Carlo Visco, Luca Arcaini, Angelo Fama, Roberto Marasca, Stefano Volpetti, Alessia Castellino, Catello Califano, Marina Cavaliere, Guido Gini, Anna Marina Liberati, Gerardo Musuraca, Anna Lucania, Giuseppina Ricciuti, Lisa Argnani, Pier Luigi Zinzani
BACKGROUND: Mantle cell lymphoma (MCL) has the worst prognosis of B-cell subtypes owing to its aggressive clinical disease course and incurability with standard chemo-immunotherapy. Options for relapsed MCL are limited, although several single agents have been studied. Lenalidomide is available in Italy for patients with MCL based on a local disposition of the Italian Drug Agency. SUBJECTS, MATERIALS, AND METHODS: An observational retrospective study was conducted in 24 Italian hematology centers with the aim to improve information on effectiveness and safety of lenalidomide use in real practice...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29674424/utilizing-radiolabeled-3-deoxy-3-18-f-fluorothymidine-with-positron-emission-tomography-to-monitor-the-effect-of-dexamethasone-on-non-small-cell-lung-cancer
#12
Christopher McHugh, Monica R Thipparthi, Jawana M Lawhorn-Crews, Lisa Polin, Shirish Gadgeel, Janice Akoury, Thomas J Mangner, Kirk A Douglas, Jing Li, Manohar Ratnam, Anthony F Shields
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality in the United States and pemetrexed-based therapies are regularly used to treat non-squamous NSCLC. Despite widespread use, pemetrexed has a modest effect on progression-free survival, with varying efficacy between individuals. Recent work has indicated that dexamethasone, given to prevent pemetrexed toxicity, is able to protect a subset of NSCLC cells from pemetrexed cytotoxicity by temporarily suppressing of the S-phase of the cell cycle...
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29673647/a-hepatic-pdna-delivery-system-based-on-an-intracellular-environment-sensitive-vitamin-e-scaffold-lipid-like-material-with-the-aid-of-an-anti-inflammatory-drug
#13
Ryohei Togashi, Hiroki Tanaka, Sakiko Nakamura, Hideo Yokota, Kota Tange, Yuta Nakai, Hiroki Yoshioka, Hideyoshi Harashima, Hidetaka Akita
Non-viral vectors are considered to be an attractive approach for gene delivery, since an artificial material is less immunogenic and oncogenic compared to a viral vector. We previously reported on the hepatic delivery of plasmid DNA (pDNA) by using lipid-like material (an SS-cleavable and pH-activated lipid-like material: ssPalm) which mounts two hydrophobic scaffolds, proton-accepting motifs (tertiary amines), and a cleavable unit (disulfide bonding). In the present study, we report on an advanced hepatic gene delivery system that uses a new type of ssPalm derivative: ssPalmE-Paz4-C2...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29673108/lenalidomide-versus-lenalidomide-dexamethasone-prolonged-treatment-after-second-line-lenalidomide-dexamethasone-induction-in-multiple-myeloma
#14
Johan Lund, Astrid Gruber, Birgitta Lauri, Adil Doganay Duru, Cecilie Blimark, Agneta Swedin, Markus Hansson, Karin Forsberg, Lucia Ahlberg, Conny Carlsson, Anders Waage, Peter Gimsing, Annette Juul Vangsted, Ulf Frølund, Erik Holmberg, Gösta Gahrton, Evren Alici, Mats Hardling, Ulf-Henrik Mellqvist, Hareth Nahi
Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single-agent Len may be effective as prolonged treatment regimen in RRMM once patients demonstrate an initial response to Len+Dex induction. Patients with RRMM who responded to first-line Len+Dex in an observational study (NCT01430546) received up to 24 cycles of either Len (25 mg/day) or Len+Dex (25 mg/day and 40 mg/week) as prolonged treatment in a subsequent phase 2 clinical trial (NCT01450215)...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29671527/single-dose-oral-dexamethasone-decreases-sore-throat-pain
#15
Allen F Shaughnessy
No abstract text is available yet for this article.
February 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671242/fbxw7%C3%AE-is-an-inducing-mediator-of-dexamethasone-induced-skeletal-muscle-atrophy-in-vivo-with-the-axis-of-fbxw7%C3%AE-myogenin-atrogenes
#16
Kyungshin Shin, Young-Gyu Ko, Jaemin Jeong, Heechung Kwon
Muscle atrophy is induced by several pathways, e.g., it can be attributed to inherited cachectic symptoms, genetic disorders, sarcopenia, or chronic side effects of treatments. However, the underlying regulatory mechanisms that contribute to muscle atrophy have not been fully elucidated. In this study, we evaluated the role of Fbxw7β, an ubiquitin E3 ligase, in a dexamethasone-induced muscle atrophy model. In this model, endogenous Fbxw7β was up-regulated; furthermore, the Fbxw7β-myogenin-atrogene axis was upregulated, supporting our previous results linking Fbxw7β to muscle atrophy in vitro...
April 18, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29670789/repeat-intravitreal-dexamethasone-implant-for-refractory-cystoid-macular-edema-in-syphilitic-uveitis
#17
Cassandra C Lautredou, Joshua S Hardin, John R Chancellor, Sami H Uwaydat, Abdallah A Ellabban, Ahmed B Sallam
Purpose: To report the successful utilization of adjunctive repeat intravitreal corticosteroid therapy for the treatment of cystoid macular edema in syphilis-related uveitis. Methods/Patients: An HIV-positive patient with treated ocular syphilis who developed refractory cystoid macular edema (CME) was treated with repeat intravitreal corticosteroid therapy including dexamethasone intravitreal implants. Results: Treatment led to the resolution of CME and improvement in visual acuity...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29670697/imidazo-2-1-b-benzothiazol-derivatives-as-potential-allosteric-inhibitors-of-the-glucocorticoid-receptor
#18
Michael S Christodoulou, Federico Dapiaggi, Francesca Ghiringhelli, Stefano Pieraccini, Maurizio Sironi, Marianna Lucafò, Debora Curci, Giuliana Decorti, Gabriele Stocco, Chandra Sekhar Chirumamilla, Wim Vanden Berghe, Patrick Balaguer, Benoît Y Michel, Alain Burger, Egle M Beccalli, Daniele Passarella, Nadine Martinet
Glucocorticoid receptor (GCR) transactivation reporter gene assays were used as an initial high-throughput screening on a diversified library of 1200 compounds for their evaluation as GCR antagonists. A class of imidazo[2,1- b ]benzothiazole and imidazo[2,1- b ]benzoimidazole derivatives were identified for their ability to modulate GCR transactivation and anti-inflammatory transrepression effects utilizing GCR and NF-κB specific reporter gene assays. Modeling studies on the crystallographic structure of the GCR ligand binding domain provided three new analogues bearing the tetrahydroimidazo[2,1- b ]benzothiazole scaffold able to antagonize the GCR in the presence of dexamethasone (DEX) and also defined their putative binding into the GCR structure...
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29670468/analysis-of-drug-effects-on-primary-human-coronary-artery-endothelial-cells-activated-by-serum-amyloid-a
#19
K Lakota, D Hrušovar, M Ogrič, K Mrak-Poljšak, S Čučnik, M Tomšič, B Božič, P Žigon, S Sodin-Semrl
Background: RA patients have a higher incidence of cardiovascular diseases compared to the general population. Serum amyloid A (SAA) is an acute-phase protein, upregulated in sera of RA patients. Aim: To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). Methods: HCAEC were preincubated for 2 h with medications from sterile ampules (dexamethasone, methotrexate, certolizumab pegol, and etanercept), dissolved in medium (captopril) or DMSO (etoricoxib, rosiglitazone, meloxicam, fluvastatin, and diclofenac)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29669605/meriones-unguiculatus-infected-by-haemonchus-contortus-evaluation-of-different-experimental-protocols
#20
L T Gressler, T H Grando, G Machado do Carmo, R A Vaucher, L M Stefani, S G Monteiro
Many important studies on resistance reversion, anthelmintic efficacy and, especially, new molecules with antiparasitic effects are performed in laboratories using gerbils (Meriones unguiculatus) as the experimental model. This study aimed to evaluate the use of corticosteroids (dexamethasone and methylprednisolone acetate) in gerbils experimentally infected with different doses of infective larvae (sheathed or exsheathed) of Haemonchus contortus. In the first experiment, 28 gerbils were divided into seven groups infected by 2-6 × 103 larvae, with or without immunosuppression using corticosteroids...
April 19, 2018: Journal of Helminthology
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