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https://www.readbyqxmd.com/read/29040876/species-specific-control-of-hepatocyte-growth-factor-expression-and-production-in-adipocytes-in-a-differentiation-dependent-manner
#1
D Yamaji, M M Soliman, A Kamikawa, T Ito, M M Ahmed, Y Okamatsu-Ogura, M Saito, K Kimura
Hepatocyte growth factor (HGF) is a mesenchymal cell-derived factor that regulates cell growth, cell motility, and morphogenesis. Since there are conflicting reports on HGF-producing cells, we herein examined HGF activity in conditioned medium (CM) of bovine and mouse preadipocytes before and after adipogenic differentiation. CM of bovine adipocytes and mouse preadipocytes induced the morphogenesis of mammary epithelial cells that was inhibited by an NK4 HGF antagonist, whereas CM of bovine preadipocytes and mouse adipocytes did not...
September 15, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29040322/dexamethasone-mediated-inhibition-of-glioblastoma-neurosphere-dispersal-in-an-ex-vivo-organotypic-neural-assay
#2
Ahmed M Meleis, Aria Mahtabfar, Shabbar Danish, Ramsey A Foty
Glioblastoma is highly aggressive. Early dispersal of the primary tumor renders localized therapy ineffective. Recurrence always occurs and leads to patient death. Prior studies have shown that dispersal of Glioblastoma can be significantly reduced by Dexamethasone (Dex), a drug currently used to control brain tumor related edema. However, due to high doses and significant side effects, treatment is tapered and discontinued as soon as edema has resolved. Prior analyses of the dispersal inhibitory effects of Dex were performed on tissue culture plastic, or polystyrene filters seeded with normal human astrocytes, conditions which inherently differ from the parenchymal architecture of neuronal tissue...
2017: PloS One
https://www.readbyqxmd.com/read/29036728/a-retrospective-study-evaluating-the-effect-of-low-doses-of-perineural-dexamethasone-on-ropivacaine-brachial-plexus-peripheral-nerve-block-analgesic-duration
#3
Gregory D Schnepper, Benjamin I Kightlinger, Yunyun Jiang, Bethany J Wolf, Eric D Bolin, Sylvia H Wilson
Objective: Examination of the effectiveness of perineural dexamethasone administered in very low and low doses on ropivacaine brachial plexus block duration. Design: Retrospective evaluation of brachial plexus block duration in a large cohort of patients receiving peripheral nerve blocks with and without perineural dexamethasone in a prospectively collected quality assurance database. Setting: A single academic medical center. Methods: A total of 1,942 brachial plexus blocks placed over a 16-month period were reviewed...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29035339/promoting-effect-of-pinostrobin-on-the-proliferation-differentiation-and-mineralization-of-murine-pre-osteoblastic-mc3t3-e1-cells
#4
Chengbo Gu, Linan Fu, Xiaohan Yuan, Zhiguo Liu
Pinostrobin (PI), a natural flavonoid found in a variety of plants, is well known for its rich pharmacological activities. However, its osteogenic function remains unclear. The aim of this study is to evaluate the effect of PI on the proliferation, differentiation, and mineralization of murine pre-osteoblastic MC3T3-E1 cells in vitro using MTT, alkaline phosphatase (ALP) activity, the synthesis of collagen I (Col I) assay, and Von-Kossa staining, respectively. The expression of osteocalcin (OCN) mRNA in cells was detected by real-time PCR...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29033931/plasmodium-berghei-nk65-in-combination-with-ifn-%C3%AE-induces-endothelial-glucocorticoid-resistance-via-sustained-activation-of-p38-and-jnk
#5
Karolina A Zielińska, Lode de Cauwer, Sofie Knoops, Kristof Van der Molen, Alexander Sneyers, Jonathan Thommis, J Brian De Souza, Ghislain Opdenakker, Karolien De Bosscher, Philippe E Van den Steen
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their therapeutic benefits remain unclear. We previously developed a mouse model of MA-ARDS, in which dexamethasone treatment revealed GC resistance. In the present study, we investigated GC sensitivity of mouse microvascular lung endothelial cells stimulated with interferon-γ (IFN-γ) and Plasmodium berghei NK65 (PbNK65)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033614/fusion-of-lower-limbs-with-severe-urogenital-malformation-in-a-newborn-a-rare-congenital-clinical-syndrome-case-report
#6
Fatemah Al Hadhoud, Abeer H Kamal, Abdulmohsen Al Anjari, Michael Fe Diejomaoh
BACKGROUND: Fused lower limbs combined with severe urogenital malformation, also known as sirenomelia, is a rare congenital clinical syndrome. The etiology is unknown, and the outcome for the affected fetus is rather uncertain. CASE REPORT: Mrs RB, a Kuwaiti woman primigravida, married to a non-consanguineous husband, had uneventful antenatal care in a private health service, until she was admitted to the Maternity Hospital, Kuwait, at 31 weeks of gestation with a 3-hour history of ruptured membranes...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29032109/early-response-to-intravitreal-dexamethasone-implant-therapy-in-diabetic-macular-edema-may-predict-visual-outcome
#7
Hasenin Al-Khersan, Seenu M Hariprasad, Jay Chhablani
PURPOSE: To determine whether early visual acuity response to intravitreal dexamethasone implant therapy in diabetic macular edema (DME) is associated with long-term outcome. DESIGN: Retrospective case series METHODS: Multicenter (eight sites) retrospective review of medical records of eyes with DME treated with 0.7mg intravitreal dexamethasone implant and minimum eighteen-month follow-up. One hundred and two eyes were included. Eyes with vitroretinal interface abnormalities or that had undergone vitrectomy were excluded...
October 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29031975/new-polymorph-form-of-dexamethasone-acetate
#8
Ronaldo Pedro da Silva, Mateus Felipe Schuchter Ambrósio, Luciana Almeida Piovesan, Maria Clara Ramalho Freitas, Daniel Lima Marques de Aguiar, Bruno Araújo Cautiero Horta, Eugenio Epprecht, Rosane Aguiar da Silva San Gil, Lorenzo do Canto Visentin
A new monohydrated polymorph of dexamethasone acetate (DEX-II) was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal (SCXRD) and polycrystal (PXRD) X-ray diffraction, solid state nuclear magnetic resonance (solid-state NMR), infrared spectroscopy (IR). A Hirshfeld surface (HS) analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule...
October 11, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29031898/comparative-analysis-of-ginsenosides-in-human-glucocorticoid-receptor-binding-transactivation-and-transrepression
#9
Catherine Hu, Aik Jiang Lau, Rui Qi Wang, Thomas K H Chang
Conflicting data exist on the effect of ginsenosides on transactivation of human glucocorticoid receptor α (herein referred to as glucocorticoid receptor), and relatively little is known regarding the effect of these chemicals on transrepression of this receptor. We investigated the effect of 20(S)-protopanaxadiol (PPD), PPD-type ginsenosides (Rb1, Rb2, Rc, Rd, Rh2, and Compound K), 20(S)-protopanaxatriol (PPT), and PPT-type ginsenosides (Re, Rf, Rg1, and Rh1) on glucocorticoid receptor binding, transactivation, and transrepression...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031716/adipocyte-glucocorticoid-receptor-is-important-in-lipolysis-and-insulin-resistance-due-to-exogenous-steroids-but-not-insulin-resistance-caused-by-high-fat-feeding
#10
Yachen Shen, Hyun Cheol Roh, Manju Kumari, Evan D Rosen
OBJECTIVE: The critical role of adipose tissue in energy and nutrient homeostasis is influenced by many external factors, including overnutrition, inflammation, and exogenous hormones. Prior studies have suggested that glucocorticoids (GCs) in particular are major drivers of physiological and pathophysiological changes in adipocytes. In order to determine whether these effects directly require the glucocorticoid receptor (GR) within adipocytes, we generated adipocyte-specific GR knockout (AGRKO) mice...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29031617/steroid-sparing-effects-of-doxofylline
#11
Yanira Riffo-Vasquez, Radhakrishnan Venkatasamy, Clive P Page
Glucocorticosteroids are widely used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). However, there are growing concerns about the side effect profile of this class of drug, particularly an increased risk of pneumonia. Over the last two decades there have been many attempts to find drugs to allow a reduction of glucocorticosteroids, including xanthines such as theophylline. Use of xanthines has been shown to lead to a reduction in the requirement for glucocorticosteroids, although xanthines also have a narrow therapeutic window limiting their wider use...
October 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29031409/a-study-of-the-pharmacokinetic-properties-and-the-in-vivo-kinetics-of-erythrocytes-loaded-with-dexamethasone-sodium-phosphate-in-healthy-volunteers
#12
REVIEW
Shodeinde A Coker, Zbigniew M Szczepiorkowski, Alan H Siegel, Antonio Ferrari, Giovanni Mambrini, Ravi Anand, Richard D Hartman, Luca Benatti, Larry J Dumont
The objectives of this 2-phase study were to elucidate pharmacokinetics (PK), in vivo 24-hour recovery, and red blood cell (RBC) survival properties of RBC-encapsulated dexamethasone sodium phosphate (DSP) prepared using the EryDex System (EDS). The 24-hour RBC recovery and T50 survival phase studied subjects randomized to receive autologous RBCs loaded with either 15-20 mg DSP (Group 1A) or sham saline (Group 2A). Loaded RBCs were radiolabeled with 51-Cr, and the labeled RBCs were followed over time in vivo...
September 19, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29031203/local-anaesthetic-pain-relief-therapy-in-vitro-and-in-vivo-evaluation-of-a-nanotechnological-formulation-co-loaded-with-ropivacaine-and-dexamethasone
#13
Yongxin Zhang, Yaocun Yue, Meng Chang
Combination therapy is frequently applied to anesthesia and analgesia for its benefits, which includes prolonged analgesia following peripheral nerve blockade, and reduced side effects. The aim of this study was to develop chitosan (CH) coated poly(ε-caprolactone) (PCL) nanoparticles to co-deliver ropivacaine (RPV) and dexamethasone (DEM) (RPV/DEM CH-PCL NPs) for the prolongation of anesthesia and pain relief. In the present study, RPV/DEM CH-PCL NPs were fabricated. The properties of CH-PCL NPs were evaluated for their particle sizes, zeta potential, drug loading capacity and in vitro drug release profile...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29029793/high-extracellular-ca-2-enhances-the-adipocyte-accumulation-of-bone-marrow-stromal-cells-through-a-decrease-in-camp
#14
Ryota Hashimoto, Youichi Katoh, Yuki Miyamoto, Kyoko Nakamura, Seigo Itoh, Hiroyuki Daida, Yuji Nakazato, Takao Okada
Bone marrow stromal cells (BMSCs) are common progenitors of both adipocytes and osteoblasts. We recently suggested that increased [Ca(2+)]o caused by bone resorption might accelerate adipocyte accumulation in response to treatment with both insulin and dexamethasone. In this study, we investigated the mechanism by which high [Ca(2+)]o enhances adipocyte accumulation. We used primary mouse BMSCs and evaluated the levels of adipocyte accumulation by measuring Oil Red O staining. CaSR agonists (both Ca(2+) and Sr(2+)) enhanced the accumulation of adipocytes among BMSCs in response to treatment with both insulin and dexamethasone...
November 2017: Cell Calcium
https://www.readbyqxmd.com/read/29029055/prognostic-models-for-9-month-mortality-in-tuberculous-meningitis
#15
Le Thi Phuong Thao, A Dorothee Heemskerk, Ronald B Geskus, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, Jeremy J Farrar, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Marcel Wolbers
Background: Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis. We developed and validated prognostic models for 9-month mortality in HIV-uninfected and HIV-infected adults with TBM. Methods: We included 1699 subjects from four randomized clinical trials and one prospective observational study conducted at two major referral hospitals in Southern Vietnam from 2001-2015. Modelling was based on multivariable Cox proportional hazards regression...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028641/postoperative-care-after-tonsillectomy-what-s-the-evidence
#16
Patrick Carpenter, Daniel Hall, Jeremy D Meier
PURPOSE OF REVIEW: The purpose of this review is to evaluate the current literature regarding postoperative management after tonsillectomy in children. RECENT FINDINGS: Controversy remains regarding the ideal medication regimen to manage pain after tonsillectomy. Acetaminophen and ibuprofen are routinely used, although concerns of more severe postoperative hemorrhage with ibuprofen remain. Narcotics are prescribed commonly, but with extreme caution in children with severe obstructive sleep apnea...
October 11, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29027825/cost-effectiveness-of-carfilzomib-plus-dexamethasone-compared-with-bortezomib-plus-dexamethasone-for-patients-with-relapsed-or-refractory-multiple-myeloma-in-the-united-states
#17
Andrzej J Jakubowiak, Ivan Houisse, István Májer, Ágnes Benedict, Marco Campioni, Sumeet Panjabi, Sikander Ailawadhi
BACKGROUND: We assessed the economic value of carfilzomib 56 mg/m(2) and dexamethasone (Kd56) vs bortezomib and dexamethasone (Vd) for relapsed/refractory multiple myeloma (R/RMM) using ENDEAVOR trial results. RESEARCH DESIGN AND METHODS: Cost-effectiveness of Kd56 vs Vd was assessed using a partitioned survival model by estimating progression-free survival, overall survival, and direct costs over a lifetime horizon. Surveillance Epidemiology and End Results (SEER) survival data were extrapolated after matching registry and ENDEAVOR patients...
October 13, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/29027645/preventive-effect-of-pre-warming-hot-compress-and-ph-adjustment-in-oxaliplatin-induced-venous-pain
#18
Hitoshi Kawazoe, Satomi Sumikawa, Kana Nakauchi, Yoshihiro Yakushijin, Yuji Yamamoto, Yuji Watanabe, Akihiro Tanaka, Hiroaki Araki
Background Venous pain induced by peripheral intravenous administration of oxaliplatin remains clinically unresolved. Objective The aim of this study was to determine the efficacy of comprehensive intervention care for venous pain in colorectal cancer patients receiving oxaliplatin. Setting A Japanese tertiary hospital. Method We treated all outpatients after April 2012 with comprehensive intervention care including pre-warming of the oxaliplatin solution, use of a hot compress, and pH adjustment by combination with dexamethasone...
October 13, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29026887/single-dose-intravenous-sodium-valproate-depakine-versus-dexamethasone-for-the-treatment-of-acute-migraine-headache-a-double-blind-randomized-clinical-trial
#19
Narges Karimi, Mahdiye Tavakoli, Jamshid Yazdani Charati, Mastoureh Shamsizade
OBJECTIVE: Migraine headache is a chronic and disabling condition in adults. Some studies have investigated the efficacy of sodium valproate in the treatment of acute migraine, but the effectiveness and tolerability of intravenous valproate as abortive therapy remains unclear. This study aimed to evaluate the effects of sodium valproate and dexamethasone in the treatment of acute migraine. METHODS: We conducted a double-blind randomized clinical trial including 90 patients aged 18 to 65 years with acute migraine headache but no aura...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29026058/clinical-utility-of-late-night-and-post-overnight-dexamethasone-suppression-salivary-cortisone-for-the-investigation-of-cushing-s-syndrome
#20
C M Ng, T K Lam, Y C Au Yeung, C H Choi, Y P Iu, C C Shek, S C Tiu
INTRODUCTION: There is a pressing need to identify diagnostic testing for Cushing's syndrome that can be achieved with ease and at low cost. This study aimed to explore the usefulness of late-night and post-overnight 1-mg dexamethasone suppression salivary cortisone, as measured by liquid chromatography-tandem mass spectrometry, for investigation of hypercortisolism. METHODS: Salivary cortisone data of subjects were investigated according to a pre-specified protocol...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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