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https://www.readbyqxmd.com/read/29474975/profile-of-cyp19a1-mrna-expression-and-aromatase-activity-during-syncytialization-of-primary-human-villous-trophoblast-cells-at-term
#1
Andrée-Anne Hudon Thibeault, Cathy Vaillancourt, J Thomas Sanderson
Estrogen production by the human villous trophoblast is dependent on the biosynthetic enzyme aromatase (CYP19; CYP19A1) and is crucial for successful placental development and pregnancy outcome. Using villous cytotrophoblast cells (vCTs) freshly isolated from normal term placenta, we characterized the promoter-specific expression of CYP19A1 mRNA (derived from promoters I.1, I.4, I.8 or total transcript) and aromatase activity during villous trophoblast syncytialization. CYP19A1 mRNA levels and aromatase activity in vCTs reached a maximum after about 48 h of culture...
February 20, 2018: Biochimie
https://www.readbyqxmd.com/read/29474901/arachidonic-acid-metabonomics-study-for-understanding-therapeutic-mechanism-of-huo-luo-xiao-ling-dan-on-rat-model-of-rheumatoid-arthritis
#2
Nannan Wang, Xiaoning Zhao, Jiaxin Huai, Yiran Li, Congcong Cheng, Kaishun Bi, Ronghua Dai
ETHNOPHARMACOLOGICAL RELEVANCE: Huo Luo Xiao Ling Dan (HLXLD), a traditional Chinese medicine (TCM), is commonly used for the treatment of rheumatoid arthritis (RA). AIM OF THE STUDY: To explore the potential therapeutic mechanism of HLXLD on anti-inflammatory activity. MATERIALS AND METHODS: A metabolomic approach based on UFLC-MS/MS to profile arachidonic acid (AA) metabolic changes was used. The cyclooxygenase (COX) and lipoxygenase (LOX) catalyzed metabolites in plasma were quantified on 7, 14, 21, and 28 days after the rats injected with Complete Freund's adjuvant and orally administrated with HLXLD, methotrexate and dexamethasone in parallel as the positive control drugs...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29473427/glucocorticoid-sensitivity-and-inflammatory-status-of-peripheral-blood-mononuclear-cells-in-patients-with-coronary-artery-disease
#3
Simon Jönsson, Anna K Lundberg, Rosanna W S Chung, Lena Jonasson
OBJECTIVE: Mechanisms behind sustained inflammation in patients with coronary artery disease (CAD) are not clarified but hypothalamus-pituitary-adrenal (HPA) axis dysfunction may have a role. Here, we investigated whether inflammatory status of peripheral blood mononuclear cells (PBMCs) was associated with altered glucocorticoid sensitivity in CAD patients. METHODS: In 55 CAD patients and 30 controls, mRNA levels of GR-α, GR-β, NF-κB, IκBα, MMP-9, and TIMP-1 were measured in PBMCs...
February 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29472721/phase-i-ii-trial-of-the-oral-regimen-ixazomib-pomalidomide-and-dexamethasone-in-relapsed-refractory-multiple-myeloma
#4
Amrita Krishnan, Prashant Kapoor, Joycelynne M Palmer, Ni-Chun Tsai, Shaji Kumar, Sagar Lonial, Myo Htut, Chatchada Karanes, Nitya Nathwani, Michael Rosenzweig, Firoozeh Sahebi, George Somlo, Lupe Duarte, James F Sanchez, Daniel Auclair, Stephen J Forman, Jesus G Berdeja
In this phase I/II trial, a triplet regimen of ixazomib (Ixa: 3 or 4 mg), pomalidomide (Pom: 4 mg), and dexamethasone (Dex: 40 mg) was administered to 32 lenalidomide-refractory multiple myeloma (MM) patients; 31 were evaluable for response and toxicity. At dose level 1 (DL1, 3 mg Ixa), 1/3 patients experienced grade 3 fatigue, grade 3 lung infection, grade 4 neutropenia, and grade 4 thrombocytopenia; all were considered dose-limiting. Per 3 + 3 phase I design, an additional three patients were enrolled to DL1, with no further dose-limiting toxicity (DLT)...
February 23, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29471299/the-effect-of-allium-cepa-extract-on-lung-oxidant-antioxidant-and-immunological-biomarkers-in-ovalbumin-sensitized-rats
#5
Narges Marefati, Naeima Eftekhar, Mahsa Kaveh, Javad Boskabadi, Farimah Beheshti, Mohammad Hossein Boskabady
OBJECTIVES: To evaluate the effects of Allium cepa (A. cepa) on levels of oxidants, antioxidants and immunological markers in the broncho-alveolar lavage fluids in sensitized rats. MATERIALS AND METHODS: Oxidant-antioxidant markers and cytokines in BALF of control rats treated with saline (group C), ovalbumin-sensitized rats (group S), rats treated with 1.25 μg/ mL dexamethasone and three doses (35, 70 and 140 mg/kg/day) of A. cepa extract (S+AC) were investigated...
February 22, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29470954/the-optical-properties-of-rat-porcine-and-human-lenses-in-organ-culture-treated-with-dexamethasone
#6
Mark Bree, Douglas Borchman
Organ culturing of lenses is useful for testing the direct effect of moieties such as cations, glucose, oxygen, antioxidants or drugs on the lens. Lens opacity changes in organ cultured lenses have never been measured quantitatively. Our aims were twofold: to establish the time course of lens opacity changes in organ cultured rat, porcine and human lenses and to test the utility of our system to measure opacity changes in lenses treated with dexamethasone. Human, porcine and rat lenses were incubated with or without 5 μM dexamethasone in minimum essential medium for 13 days...
February 19, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29469592/ixazomib-in-the-management-of-relapsed-multiple-myeloma
#7
Cyrille Touzeau, Philippe Moreau
The development of proteasome inhibitors contributed to the dramatic life expectancy improvement observed in myeloma patients over the past decades. Ixazomib is a boron-containing selective and reversible proteasome inhibitor that demonstrated antimyeloma activity with excellent safety profile. Ixazomib is the first orally available proteasome inhibitor approved in combination with lenalidomide and dexamethasone for the treatment of myeloma patients who received at least one prior therapy. The present review addresses the current knowledge regarding the clinical use of ixazomib in relapsed myeloma patients...
February 22, 2018: Future Oncology
https://www.readbyqxmd.com/read/29468652/response-and-survival-for-primary-therapy-combination-regimens-and-maintenance-rituximab-in-waldenstr%C3%A3-m-macroglobulinaemia
#8
Jorge J Castillo, Joshua N Gustine, Kirsten Meid, Toni E Dubeau, Patricia Severns, Lian Xu, Guang Yang, Zachary R Hunter, Steven P Treon
Waldenström macroglobulinaemia (WM) is a rare and incurable lymphoma. Comparative studies evaluating the efficacy of primary therapy in symptomatic WM patients have not been performed. In this study, we compared response and survival outcomes in WM patients who received primary therapy with cyclophosphamide-dexamethasone-rituximab (CDR), bortezomib-dexamethasone-rituximab (BDR) and bendamustine-rituximab (Benda-R), as well as maintenance rituximab following primary therapy. Analyses were adjusted for relevant clinical factors associated with response and survival...
February 22, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29467805/reduction-of-optic-disc-oedema-by-bortezomib-and-dexamethasone-followed-by-autologous-peripheral-blood-stem-cell-transplantation-in-patient-with-poems-syndrome
#9
Takehito Iwase, Hirotaka Yokouchi, Sonoko Misawa, Toshiyuki Oshitari, Takayuki Baba, Satoshi Kuwabara, Shuichi Yamamoto
The authors present findings in a 39-year-old man with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome with bilateral optic disc oedema. He was successfully treated with bortezomib and dexamethasone followed by autologous peripheral blood stem cell transplantation. The peripapillary retinal thickness was reduced in the optical coherence tomographic (OCT) images along with a decrease of the serum vascular endothelial growth factor (VEGF) levels. The authors recommend OCT to monitor the changes in the signs of POEMS syndrome after treatments...
February 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29466449/nitric-oxide-mediates-antimicrobial-peptide-gene-expression-by-activating-eicosanoid-signaling
#10
Md Sadekuzzaman, Yonggyun Kim
Nitric oxide (NO) mediates both cellular and humoral immune responses in insects. Its mediation of cellular immune responses uses eicosanoids as a downstream signal. However, the cross-talk with two immune mediators was not known in humoral immune responses. This study focuses on cross-talk between two immune mediators in inducing gene expression of anti-microbial peptides (AMPs) of a lepidopteran insect, Spodoptera exigua. Up-regulation of eight AMPs was observed in S. exigua against bacterial challenge. However, the AMP induction was suppressed by injection of an NO synthase inhibitor, L-NAME, while little expressional change was observed on injecting its enantiomer, D-NAME...
2018: PloS One
https://www.readbyqxmd.com/read/29465463/novel-therapeutics-for-bronchopulmonary-dysplasia
#11
Lannae Strueby, Bernard Thébaud
PURPOSE OF REVIEW: This review provides a concise summary of recent literature pertaining to emerging therapies for bronchopulmonary dysplasia (BPD). To provide context for the presented therapies, a brief overview of recently proposed changes to the definition of BPD and the concept of expanded respiratory outcomes is included. RECENT FINDINGS: New or redefined respiratory outcomes are required to improve accuracy in evaluating new therapies and correlating results with long-term clinical outcomes of importance...
February 19, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29465271/cd38-targeting-antibodies-in-multiple-myeloma-mechanisms-of-action-and-clinical-experience
#12
Kristine A Frerichs, Noemi Anna Nagy, Pieter L Lindenbergh, Patty Bosman, Jhon Marin Soto, Marloes Broekmans, Richard W J Groen, Maria Themeli, Louise Nieuwenhuis, Claudia Stege, Inger S Nijhof, Tuna Mutis, Sonja Zweegman, Henk M Lokhorst, Niels W C J van de Donk
Multiple myeloma (MM) is generally an incurable hematological malignancy with heterogeneous overall survival rates ranging from a few months to more than 10 years. Survival is especially poor for patients who developed disease that is refractory to immunomodulatory drugs and proteasome inhibitors. Areas covered: This review will discuss the importance of CD38-targeting antibodies for the treatment of MM patients to improve their outcome. Expert commentary: Intense immuno-oncological laboratory research has resulted in the development of functionally active monoclonal antibodies against cell surface markers present on MM cells...
February 21, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29465045/sugammadex-improves-neuromuscular-function-in-patients-receiving-perioperative-steroids
#13
A B Ozer, E Bolat, O L Erhan, M Kilinc, I Demirel, G Caglar Toprak
Context: Sugammadex has steroid-encapsulating effect. Aim: This study was undertaken to assess whether the clinical efficacy of sugammadex was altered by the administration of steroids. Setting and Design: Sixty patients between 18 and 60 years of age with the American Society of Anesthesiologists I-IV and undergoing elective direct laryngoscopy/biopsy were included in this study. Materials and Methods: Patients were assigned to two groups based on the intraoperative steroid use: those who received steroid (Group S) and who did not (Group C)...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29464867/blunted-cortisol-response-to-stress-in-patients-with-eating-disorders-its-association-to-bulimic-features
#14
Francisco J Vaz-Leal, María I Ramos-Fuentes, Laura Rodríguez-Santos, Carlos Chimpén-López, Nieves Fernández-Sánchez, Francisco J Zamora-Rodríguez, Luis Beato-Fernández, Luis Rojo-Moreno, Juan A Guisado-Macías
OBJECTIVE: Clinical research on cortisol response to stress in patients with eating disorders has provided controversial and even contradictory results. As this might be the consequence of the inclusion in the studies of heterogeneous clinical populations, 3 highly selected samples were studied. METHODS: Dexamethasone suppression test was performed on 15 restricting anorexia nervosa patients without history of bulimia nervosa (BN), 17 BN patients with normal weight and no history of anorexia nervosa, and 22 healthy controls...
February 21, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29464158/hyperbaric-oxygen-for-ischemia-due-to-injection-of-cosmetic-fillers-case-report-and-issues
#15
Raven Henderson, Debra A Reilly, Jeffrey S Cooper
Natural and synthetic fillers have revolutionized aesthetic facial rejuvenation and soft-tissue augmentation. We present a case highlighting the dangers of filler self-injection. A 37-year-old woman self-injected a dermal filler around both temples. She immediately experienced left--side hearing loss, blanching over the left face, and pain. Prompt treatment with hyaluronidase, topical nitro paste, and warm compresses ensued. An emergency computed tomography angiogram showed occlusion of a superficial temporal artery branch...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29463825/nanostructured-polymer-thin-films-fabricated-with-brush-based-layer-by-layer-self-assembly-for-site-selective-construction-and-drug-release
#16
Kyungtae Park, Daheui Choi, Jinkee Hong
Layer-by-Layer (LbL) self-assembly has been investigated for several decades. However, the conventional LbL method has performance problems on the chair-side caused by its cumbersome and time-consuming process. Thus, we investigate a new LbL self-assembly technique for the fast and high efficient preparation process based on the brush. The multilayer films fabricated by simple sequential brushing of polyelectrolyte solutions are compared to the classical dipping method. We characterize the multilayer films by characteristics such as their morphology and thickness, and compare them against those of the classic method by profilometry, atomic force microscopy...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463809/delivery-of-exogenous-mitochondria-via-centrifugation-enhances-cellular-metabolic-function
#17
Mi Jin Kim, Jung Wook Hwang, Chang-Koo Yun, Youngjun Lee, Yong-Soo Choi
Mitochondria are essential organelles involved in the maintenance of cell growth and function, and have been investigated as therapeutic targets in various diseases. Recent studies have demonstrated that direct mitochondrial transfer can restore cellular functions of cells with inherited or acquired mitochondrial dysfunction. However, previous mitochondrial transfer methods are inefficient and time-consuming. Here, we developed a simple and easy mitochondrial transfer protocol using centrifugation, which can be applied to any cell type...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29461671/functional-characterization-of-the-citrus-canker-susceptibility-gene-cslob1
#18
Shuo Duan, Hongge Jia, Zhiqian Pang, Doron Teper, Frank White, Jeffrey Jones, Changyong Zhou, Nian Wang
Xanthomonas citri ssp. citri (Xcc) is an important plant pathogenic bacterium that causes citrus canker disease worldwide. PthA, a transcriptional activator-like (TAL) effector, directs the expression of canker susceptibility gene CsLOB1. Here, we report our recent progress in functional characterization of CsLOB1. Subcellular localization analysis of CsLOB1 protein in citrus protoplast revealed that CsLOB1 is primarily localized in the nucleus. We showed that CsLOB1 expression driven by the dexamethasone (DEX) in the CsLOB1-GR transgenic plants is associated with pustule formation following treatment with DEX...
February 20, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29461171/new-model-of-proliferative-vitreoretinopathy-in-rabbit-for-drug-delivery-and-pharmacodynamic-studies
#19
Sang Woong Moon, Yaoyao Sun, David Warther, Kristyn Huffman, William R Freeman, Michael J Sailor, Lingyun Cheng
Blinding retinal diseases become more epidemic as the population ages. These diseases, such as diabetic retinopathy and macular edema, are of chronic nature and require protracted drug presence at the disease site. A sustained intravitreal porous silicon delivery system with dexamethasone (pSiO2 -COO-DEX) was evaluated in a new rabbit model of proliferative vitreoretinopathy (PVR) in a real treatment design. In contrast to the pretreatment design model, pSiO2 -COO-DEX was intravitreally injected into the eyes with active inflammation...
January 1, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29460666/effects-of-common-ear-drops-on-tympanic-membrane-healing-in-rats
#20
Carolyn O Dirain, Brendan Kosko, Patrick J Antonelli
Objective Ciprofloxacin + dexamethasone ear drops have been associated with higher rates of tympanic membrane perforations than ofloxacin. This was thought to be an effect of the steroid; however, ciprofloxacin (sans steroid) has been found to be more toxic to tympanic membrane fibroblasts than ofloxacin in vitro. This study aimed to compare the effect of these agents on tympanic membrane healing in vivo. Study Design Controlled animal study. Setting Academic research laboratory. Methods Perforations were created in 54 rats with a carbon dioxide laser...
February 1, 2018: Otolaryngology—Head and Neck Surgery
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