Won-Hwan Park, Han-Kyu Kim, Kyung-Soo Nam, Yun-Hee Shon, Byung Hun Jeon, Sung-Kwon Moon, Min-Gon Kim, Cheorl-Ho Kim
Geiji-Bokryung-Hwan (GBH) was studied on antiplatelet activity in human platelet suspensions. GBH consists of the 5 herbs Cinnamomi Ramulus, Poria Cocos, Mountan Cortex Radicis, Paeoniae Radix, and Persicae Semen, which have been used in herbal medicine for thousands of years for atherosclerosis. The mechanism involved in the antiplatelet activity of GBH in human platelet suspensions was investigated. GBH inhibited platelet aggregation and Ca2+ mobilization in a concentration-dependent manner without increasing intracellular cyclic AMP and cyclic GMP...
November 5, 2004: Life Sciences