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fetal movements

Adam D Jakes, Rebecca Whybrow, Clare Spencer, Lucy C Chappell
No abstract text is available yet for this article.
March 6, 2018: BMJ: British Medical Journal
Mohammad Ghasem Hanafi, Aliakbar Sahraeizadeh
INTRODUCTION: The objective is to assess if fetal halogen light stimulation can reduce the time needed to obtain a normal biophysical profile (BPP). METHODS: Patients scheduled for a BPP and who satisfied the inclusion criteria were prospectively randomized to halogen light stimulation and no stimulation groups. The study group was exposed to handheld halogen light for 10 s whenever fetal breathing, movement, or tone was absent through the first 5 min of BPP. The time required to achieve complete BPP score was recorded...
February 22, 2018: Journal of Medical Ultrasonics
Hsiu-Huei Peng, Sheng-Wen Shaw, Kuan-Gen Huang
OBJECTIVE: Glutaric aciduria type 1 is a rare disease, with the estimated prevalence about 1 in 100,000 newborns. GCDH gene mutation can lead to glutaric acid and 3- OH glutaric acid accumulation, with clinical manifestation of neuronal damage, brain atrophy, microencephalic macrocephaly, decreased coordination of swallowing, poor muscle coordination, spasticity, and severe dystonic movement disorder. CASE REPORT: A 22-year-old female, Gravida 4 Para 2, is pregnancy at 13 weeks of gestational age...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
B T Green, S T Lee, J W Keele, K D Welch, D Cook, J A Pfister, W R Kem
Four chemically similar alkaloids, anabasine, anabaseine, epibatidine and dimethylphenylpiperazinium (DMPP), are potent nicotinic acetylcholine receptor agonists of fetal muscle nicotinic acetylcholine receptors in human TE-671 cells. Based on results with these cells, we hypothesized that the alkaloids would completely inhibit ultrasound-monitored fetal movement in a goat model. Different, single doses of anabasine, anabaseine, epibatidine, DMPP, or saline control were administered I.V. to pregnant goats on day 40 of gestation and the number of fetal movements per 5 min sample was measured by ultrasound at times 0, 0...
February 13, 2018: Toxicon: Official Journal of the International Society on Toxinology
Iris Tomantschger, Dafne Herrero, Christa Einspieler, Cristina Hamamura, Mariana Calil Voos, Peter B Marschik
Abnormal general movements are among the most reliable markers for cerebral palsy. General movements are part of the spontaneous motor repertoire and are present from early fetal life until the end of the first half year after term. In addition to its high sensitivity (98%) and specificity (91%), the assessment of general movements is non-invasive and time- and cost-efficient. It is therefore ideal for assessing the integrity of the young nervous system, most notably in lowresource settings. Studies on the general movements assessment in low- and middle-income countries such as China, India, Iran, or South Africa are still rare but increasing...
February 5, 2018: Revista de Saúde Pública
Jiao Li, Zheng Wang, Qiqi Chu, Kewu Jiang, Juan Li, Nan Tang
The differentiation of alveolar epithelial type I (AT1) and type II (AT2) cells is essential for the lung gas exchange function. Disruption of this process results in neonatal death or in severe lung diseases that last into adulthood. We developed live imaging techniques to characterize the mechanisms that control alveolar epithelial cell differentiation. We discovered that mechanical forces generated from the inhalation of amniotic fluid by fetal breathing movements are essential for AT1 cell differentiation...
February 5, 2018: Developmental Cell
Alexander E P Heazell, Tomasina Stacey, Louise M O'Brien, Edwin A Mitchell, Jane Warland
Changes in fetal movement are associated with increased risk of stillbirth after 28 weeks of pregnancy. The majority of studies have focussed on maternal perception of reduced fetal movements, which is associated with stillbirth via placental dysfunction. Recent studies have also described an association between a single episode of excessive fetal movements and late stillbirth. We present a hypothesis that a sudden episode of excessive fetal activity indicates fetal compromise relating to underlying disturbance of the in utero environment, which if it persists can lead to fetal death...
February 2018: Medical Hypotheses
Mihaela Grigore, Dumitru Gafitanu, Demetra Socolov, AnaMaria Grigore, Georgiana Nemeti, Romeo Micu
The introduction of four-dimensional (4D) ultrasonography (US) allows the study of fetal movements and facial expressions in real time. The possibility of evaluating fetal movements has led to the study of fetal neurobehaviour, which has been for a long period of time a mystery for physicians. The study of fetal activity in utero could differentiate between normal and abnormal behavioural patterns, thus making possible the early recognition of fetal brain impairment. Facial expressions observed with 4D US represent a marker for neurobehaviour and at the same time could enhance fetal-maternal bonding...
February 4, 2018: Medical Ultrasonography
Umberto Castiello, Valentina Parma
This Viewpoint examines recent developments in the quantitative characterization of fetal movements via kinematical analysis. We contend that fetal kinematics represents a powerful tool to investigate prenatal cognition and the prepostnatal continuity of cognitive development. The potential benefits of increased investigation into the kinematics of fetal movement are manifold, and apply to diverse fields including pediatric medicine and developmental biology.
January 30, 2018: ACS Chemical Neuroscience
Stefaan W Verbruggen, Bernhard Kainz, Susan C Shelmerdine, Joseph V Hajnal, Mary A Rutherford, Owen J Arthurs, Andrew T M Phillips, Niamh C Nowlan
Mechanical forces generated by fetal kicks and movements result in stimulation of the fetal skeleton in the form of stress and strain. This stimulation is known to be critical for prenatal musculoskeletal development; indeed, abnormal or absent movements have been implicated in multiple congenital disorders. However, the mechanical stress and strain experienced by the developing human skeleton in utero have never before been characterized. Here, we quantify the biomechanics of fetal movements during the second half of gestation by modelling fetal movements captured using novel cine-magnetic resonance imaging technology...
January 2018: Journal of the Royal Society, Interface
Lisa M Daly, Glenn Gardener, Victoria Bowring, Wendy Burton, Yogesh Chadha, David Ellwood, Frederik Frøen, Adrienne Gordon, Alexander Heazell, Kassam Mahomed, Susan McDonald, Jane E Norman, Jeremy Oats, Vicki Flenady
The National Health and Medical Research Council (NHMRC) Centre of Research Excellence in Stillbirth and the Perinatal Society of Australia and New Zealand (PSANZ) have recently partnered in updating an important clinical practice guideline, Care of pregnant women with decreased fetal movements. This guideline offers 12 recommendations and a suggested care pathway, with the aim to improve the quality of care for women reporting decreased fetal movements through an evidence-based approach. Adoption of the guideline by clinicians and maternity hospitals could result in earlier identification of higher-risk pregnancies, improved perinatal health outcomes for women and their babies, and reduced stillbirth rates...
January 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Fang Liu, Guirong Zhang, Xue Sheng, Shang Liu, Meng Cui, Heyun Guo, Jianbin Xue, Lingyun Zhang
Obesity in pregnant women presents a risk to fetal health, leading to numerous metabolic syndromes and chronic inflammation risks. Previously, physical exercise was considered to be one of the primary treatments for obesity. However, the effect of fat consumption throughout the life cycle on physical endurance capacity remains unknown. A total of two groups of female mice (age, 6 weeks; C57BL/6J) were fed with a normal chow diet and a moderate high fat diet (MHFD), during pregnancy and lactation (8 weeks), with the offspring receiving the same diet as the mother...
January 16, 2018: Molecular Medicine Reports
S Wang, H X Yang
Objective: To study the cause of intrauterine fetal death (IUFD) in 17 years. Methods: From June 1(st), 2000 to May 31(st), 2017, 65 621 women delivered in Peking University First Hospital. Clinical data of 105 cases of IUFD (including 82 singleton pregnancies and 23 twin pregnancies) during the 17 years were analyzed retrospectively. Results: (1) In singleton pregnancies, the leading cause of IUFD was maternal complications, including severe pre-eclampsia (36/82, 43.9%) and diabetes mellitus (6/82, 7.3%). The second reason was umbilical cord factors (13/82, 15...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
Nitish Chourasia, Michael W Watkins, Jeremy E Lankford, Joseph S Kass, Ankur Kamdar
BACKGROUND: Anti-N-Methyl-D-Aspartate receptor (NMDAR) encephalitis is an autoimmune disorder that often affects women of childbearing age, and maternal-fetal transfer of anti-NMDAR antibodies during pregnancy has been documented in both symptomatic and asymptomatic women. The effects of these antibodies on the fetus, however, are incompletely understood. PATIENT DESCRIPTION: This term infant exhibited depressed respiratory effort, poor feeding, and abnormal movements after birth...
November 22, 2017: Pediatric Neurology
Raul Moreira Neto, Selma Porovic
Fetal neurology is evolving as an area of great interest in prenatal diagnosis and fetal medicine. The identification and diagnosis of brain damage prenatally has been a great challenge in obstetrics for many years. Investigations of fetal behavior in comparison with morphological studies led to the conclusion that fetal behavioral patterns directly reflect developmental and maturational processes of the fetal central nervous system (CNS). Four-dimensional (4D) ultrasound has greatly improved the assessment of the quality of the fetal spontaneous movements, and enabled a better evaluation of fetal behavior...
January 8, 2018: Journal of Perinatal Medicine
Billie Bradford, Robyn Maude
PROBLEM: Decreased fetal movements is a common reason for unscheduled antenatal assessment and is associated with adverse pregnancy outcome. BACKGROUND: Fetal movement counting has not been proven to reduce stillbirths in high-quality studies. AIMS: The aim was to explore a qualitative account of fetal movements in the third trimester as perceived by pregnant women themselves. METHODS: Using qualitative descriptive methodology, interviews were conducted with 19 women experiencing an uncomplicated first pregnancy, at two timepoints in their third trimester...
December 26, 2017: Women and Birth: Journal of the Australian College of Midwives
Magdalena Jansova, Vladimir Kalis, Zdenek Rusavy, Sari Räisänen, Libor Lobovsky, Katariina Laine
OBJECTIVE: The aim of this study was to evaluate whether a previously identified modification of Viennese method of perineal protection remains most effective for reduction of perineal tension in cases with substantially smaller or larger fetal heads. METHODS: A previously designed finite element model was used to compare perineal tension of different modifications of the Viennese method of perineal protection to "hands-off" technique for three different sizes of the fetal head...
2017: PloS One
Eiji Ryo, Hideo Kamata, Michiharu Seto, Masayoshi Morita, Yohei Nagaya, Kyoko Nishihara, Noboru Ohki
BACKGROUND: A newly developed fetal movement acceleration measurement recorder has made it possible to count gross movements for hours. The purpose of this study was to determine the normal reference values for such movements. METHODS: One hundred and six pregnant women recorded fetal movements by themselves when they slept at home weekly from 28 weeks to term. The normal reference values were determined based on the data that could be recorded for more than four hours per night...
December 27, 2017: Pediatric Research
Nasser Abu Awad, Thomas Jordan, Robert Mundle, Dan Farine
OBJECTIVE: To review the management and outcome of pregnancies of women presenting to obstetrical triage with decreased fetal movements (DFM). STUDY DESIGN: A retrospective review of women presenting with DFMs to two large Canadian obstetrical centres with a combined 9490 deliveries per year. The charts were reviewed for compliance with the Canadian guidelines for demographics (age, parity, GA, comorbidities, etc.), pregnancy management (admission vs. discharge, need to deliver), and pregnancy outcomes (mortality, morbidity, GA at delivery, Apgar scores, etc...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Atif A Ahmed, Priya Skaria, Nicole P Safina, Isabelle Thiffault, Alex Kats, Eugenio Taboada, Sultan Habeebu, Carol Saunders
Arthrogryposis multiplex congenita affects approximately 1 in 3,000 individuals of different ethnic backgrounds and displays an equal incidence in males and females. The underlying mechanism for congenital contracture of the joints is decreased fetal movement during intrauterine development. This disorder is associated with over 400 medical conditions and 350 known genes that display considerable variability in phenotypic expression. In this report, four fetal or perinatal autopsy cases of arthrogryposis were studied by gross morphology, microscopic histopathologic examination, and whole genome sequencing of postmortem DNA...
December 23, 2017: American Journal of Medical Genetics. Part A
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