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https://www.readbyqxmd.com/read/29325265/-clinical-analysis-of-105-intrauterine-fetal-deaths-in-17-years
#1
S Wang, H X Yang
Objective: To study the cause of intrauterine fetal death (IUFD) in 17 years. Methods: From June 1(st), 2000 to May 31(st), 2017, 65 621 women delivered in Peking University First Hospital. Clinical data of 105 cases of IUFD (including 82 singleton pregnancies and 23 twin pregnancies) during the 17 years were analyzed retrospectively. Results: (1) In singleton pregnancies, the leading cause of IUFD was maternal complications, including severe pre-eclampsia (36/82, 43.9%) and diabetes mellitus (6/82, 7.3%). The second reason was umbilical cord factors (13/82, 15...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29310908/an-infant-born-to-a-mother-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#2
Nitish Chourasia, Michael W Watkins, Jeremy E Lankford, Joseph S Kass, Ankur Kamdar
BACKGROUND: Anti-N-Methyl-D-Aspartate receptor (NMDAR) encephalitis is an autoimmune disorder that often affects women of childbearing age, and maternal-fetal transfer of anti-NMDAR antibodies during pregnancy has been documented in both symptomatic and asymptomatic women. The effects of these antibodies on the fetus, however, are incompletely understood. PATIENT DESCRIPTION: This term infant exhibited depressed respiratory effort, poor feeding, and abnormal movements after birth...
November 22, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29306932/clinical-study-of-fetal-neurobehavior-by-the-kanet-test
#3
REVIEW
Raul Moreira Neto, Selma Porovic
Fetal neurology is evolving as an area of great interest in prenatal diagnosis and fetal medicine. The identification and diagnosis of brain damage prenatally has been a great challenge in obstetrics for many years. Investigations of fetal behavior in comparison with morphological studies led to the conclusion that fetal behavioral patterns directly reflect developmental and maturational processes of the fetal central nervous system (CNS). Four-dimensional (4D) ultrasound has greatly improved the assessment of the quality of the fetal spontaneous movements, and enabled a better evaluation of fetal behavior...
January 8, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29287635/maternal-perception-of-fetal-movements-in-the-third-trimester-a-qualitative-description
#4
Billie Bradford, Robyn Maude
PROBLEM: Decreased fetal movements is a common reason for unscheduled antenatal assessment and is associated with adverse pregnancy outcome. BACKGROUND: Fetal movement counting has not been proven to reduce stillbirths in high-quality studies. AIMS: The aim was to explore a qualitative account of fetal movements in the third trimester as perceived by pregnant women themselves. METHODS: Using qualitative descriptive methodology, interviews were conducted with 19 women experiencing an uncomplicated first pregnancy, at two timepoints in their third trimester...
December 26, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29287104/fetal-head-size-and-effect-of-manual-perineal-protection
#5
Magdalena Jansova, Vladimir Kalis, Zdenek Rusavy, Sari Räisänen, Libor Lobovsky, Katariina Laine
OBJECTIVE: The aim of this study was to evaluate whether a previously identified modification of Viennese method of perineal protection remains most effective for reduction of perineal tension in cases with substantially smaller or larger fetal heads. METHODS: A previously designed finite element model was used to compare perineal tension of different modifications of the Viennese method of perineal protection to "hands-off" technique for three different sizes of the fetal head...
2017: PloS One
https://www.readbyqxmd.com/read/29281617/reference-values-for-a-fetal-movement-acceleration-measurement-recorder-to-count-fetal-movements
#6
Eiji Ryo, Hideo Kamata, Michiharu Seto, Masayoshi Morita, Yohei Nagaya, Kyoko Nishihara, Noboru Ohki
BACKGROUND: A newly developed fetal movement acceleration measurement recorder has made it possible to count gross movements for hours. The purpose of this study was to determine the normal reference values for such movements. METHODS: One hundred and six pregnant women recorded fetal movements by themselves when they slept at home weekly from 28 weeks to term. The normal reference values were determined based on the data that could be recorded for more than four hours per night...
December 27, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29276160/management-and-outcome-of-reduced-fetal-movements-is-ultrasound-necessary
#7
Nasser Abu Awad, Thomas Jordan, Robert Mundle, Dan Farine
OBJECTIVE: To review the management and outcome of pregnancies of women presenting to obstetrical triage with decreased fetal movements (DFM). STUDY DESIGN: A retrospective review of women presenting with DFMs to two large Canadian obstetrical centres with a combined 9490 deliveries per year. The charts were reviewed for compliance with the Canadian guidelines for demographics (age, parity, GA, comorbidities, etc.), pregnancy management (admission vs. discharge, need to deliver), and pregnancy outcomes (mortality, morbidity, GA at delivery, Apgar scores, etc...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29274205/arthrogryposis-and-pterygia-as-lethal-end-manifestations-of-genetically-defined-congenital-myopathies
#8
Atif A Ahmed, Priya Skaria, Nicole P Safina, Isabelle Thiffault, Alex Kats, Eugenio Taboada, Sultan Habeebu, Carol Saunders
Arthrogryposis multiplex congenita affects approximately 1 in 3,000 individuals of different ethnic backgrounds and displays an equal incidence in males and females. The underlying mechanism for congenital contracture of the joints is decreased fetal movement during intrauterine development. This disorder is associated with over 400 medical conditions and 350 known genes that display considerable variability in phenotypic expression. In this report, four fetal or perinatal autopsy cases of arthrogryposis were studied by gross morphology, microscopic histopathologic examination, and whole genome sequencing of postmortem DNA...
December 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29246577/the-management-of-myelomeningocele-study-full-cohort-30-month-pediatric-outcomes
#9
Diana L Farmer, Elizabeth A Thom, John W Brock, Pamela K Burrows, Mark P Johnson, Lori J Howell, Jody A Farrell, Nalin Gupta, N Scott Adzick
BACKGROUND: Previous reports from the Management of Myelomeningocele Study (MOMS) demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation, the need for cerebrospinal fluid shunting, and improves motor function in children with myelomeningocele. The trial was stopped for efficacy after 183 patients had been randomized, but 30-month outcomes were only available at the time of initial publication in 134 mother-child dyads. Data from the complete cohort for the 30-month outcomes are presented here...
December 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29243326/three-dimensional-ultrasound-cranial-imaging-and-early-neurodevelopment-in-preterm-growth-restricted-infants
#10
Glenda McLean, Catherine Hough, Arvind Sehgal, Michael Ditchfield, Graeme R Polglase, Suzanne L Miller
AIM: Fetal growth restriction (FGR) is associated with increased perinatal morbidity, mortality and long-term neurodevelopmental sequelae. The objective of this study was to examine whether information about early neurodevelopmental deficits was evident using three-dimensional head ultrasound and developmental assessments in preterm infants with FGR, compared with appropriate for gestational age (AGA) infants in the early post-natal period. METHODS: Twenty preterm FGR infants weighing <10th centile and born between 28 and 32 weeks were compared with age-matched AGA infants...
December 15, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29235099/variations-from-morning-to-afternoon-of-middle-cerebral-and-umbilical-artery-blood-flow-and-fetal-heart-rate-variability-and-fetal-characteristics-in-the-normally-developing-fetus
#11
Tehila Avitan, Ari Sanders, Ursula Brain, Dan Rurak, Tim F Oberlander, Ken Lim
OBJECTIVE: To determine if there are changes in maternal uterine blood flow, fetal brain blood flow, fetal heart rate variability, and umbilical blood flow between morning (AM) and afternoon (PM) in healthy, uncomplicated pregnancies. STUDY DESIGN: In this prospective study, 68 uncomplicated singleton pregnancies (mean 35 + 0.7 weeks gestation) underwent a standard observational protocol at both 08:00 (AM) and 13:30 (PM) of the same day. This protocol included Doppler measurements of uterine, umbilical, and fetal middle cerebral artery (MCA) volume flow parameters (flow, HR, peak systolic velocity [PSV], PI, and RI) followed by computerized cardiotocography...
December 13, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29230337/prenatal-diagnosis-of-a-segmental-small-bowel-volvulus-with-threatened-premature-labor
#12
Barbara Monard, Nicolas Mottet, Rajeev Ramanah, Didier Riethmuller
Fetal primary small bowel volvulus is extremely rare but represents a serious life-threatening condition needing emergency neonatal surgical management to avoid severe digestive consequences. We report a case of primary small bowel volvulus with meconium peritonitis prenatally diagnosed at 27 weeks and 4 days of gestation during threatened premature labor with reduced fetal movements. Ultrasound showed a small bowel mildly dilated with thickened and hyperechogenic intestinal wall, with a typical whirlpool configuration...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29220528/maternal-thyroid-function-in-early-pregnancy-and-neuropsychological-performance-of-the-child-at-5-years-of-age
#13
Stine Linding Andersen, Stig Andersen, Zeyan Liew, Peter Vestergaard, Jørn Olsen
Context: Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis. Objective: To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age. Design: Follow-up study. Participants: A cohort of 1,153 women and their children sampled from the Danish National Birth Cohort...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29196664/the-origin-of-human-handedness-and-its-role-in-pre-birth-motor-control
#14
Valentina Parma, Romain Brasselet, Stefania Zoia, Maria Bulgheroni, Umberto Castiello
The vast majority of humans are right-handed, but how and when this bias emerges during human ontogenesis is still unclear. We propose an approach that explains postnatal handedness starting from 18 gestational weeks using a kinematic analysis of different fetal arm movements recorded during ultrasonography. Based on the hand dominance reported postnatally at age 9, the fetuses were classified as right-handed (86%) or left-handed, in line with population data. We revealed that both right-handed and left-handed fetuses were faster to reach to targets requiring greater precision (i...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194396/aquaporins-during-pregnancy-their-function-and-significance
#15
REVIEW
Eszter Ducza, Adrienn Csányi, Róbert Gáspár
Water is the major component of cells and tissues, and the movement of water across the cell membrane is a fundamental property of life. Until the discovery of the first water channel, aquaporin, it was long assumed that the transport of water was due to simple diffusion through the lipid bilayer membrane that encloses cells. Aquaporin (AQP) molecules were first discovered in the human uterus in 1994, and since then several studies have investigated these channels in the female reproductive system. The expressions of AQPs have been proven in the reproductive system...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29155192/external-genital-development-urethra-formation-and-hypospadias-induction-in-guinea-pig-a-double-zipper-model-for-human-urethral-development
#16
Shanshan Wang, Mingxin Shi, Dongqing Zhu, Ranjiv Mathews, Zhengui Zheng
OBJECTIVES: To determine whether the guinea pig phallus would be an appropriate model of human penile development, we characterized the embryology and sexual differentiation of guinea pig external genitalia and attend to induce hypospadias in males and tubular urethra formation in females pharmacologically. MATERIALS AND METHODS: The external genitalia of guinea pig were collected from genital swelling initiation to newborn stages and Scanning Electronic Microscopy and histology were performed to visualize the morphology and structure...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29132322/stillbirth-is-associated-with-perceived-alterations-in-fetal-activity-findings-from-an-international-case-control-study
#17
Alexander E P Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A Mitchell, Louise M O'Brien
BACKGROUND: Stillbirth after 28 weeks gestation affects between 1.3-8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification of risk factors which could be identified and managed in pregnancy is a priority in stillbirth prevention research. This study aimed to evaluate women's experiences of fetal movements and how these relate to stillbirth. METHODS: An international internet-based case-control study of women who had a stillbirth ≥28 weeks' gestation within 30 days prior to completing the survey (n = 153) and women with an ongoing pregnancy or a live born child (n = 480)...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29105374/from-adult-finger-tapping-to-fetal-heart-beating-retracing-the-role-of-coordination-in-constituting-agency
#18
Alessandro Solfo, Cees van Leeuwen
Sense of agency can be defined as the self-awareness of bodily movement, whereas extended agency as the self-awareness of affecting, through movement, events concomitant with movement. As a distinctive manifestation of agency, we review Spizzo's effect. This effect arises when agents coordinate their rhythmic movements with visual pulses. Once coordination is established, agents feel controlling the onset or the offset of the pulses through their movements. Spizzo's effect, therefore, constitutes a manifest case of extended agency, in which agents are aware of controlling, through movement, the pulses temporally concomitant with movement...
November 3, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/29098534/impairment-of-astrocytic-glutaminolysis-in-glutaric-aciduria-type-i
#19
Shoko Komatsuzaki, Raga Deepthi Ediga, Jürgen G Okun, Stefan Kölker, Sven W Sauer
Glutaric aciduria type I is a rare, autosomal recessive, inherited defect of glutaryl-CoA dehydrogenase. Deficiency of this protein in L-lysine degradation leads to the characteristic accumulation of nontoxic glutarylcarnitine and neurotoxic glutaric acid (GA), glutaryl-CoA, and 3-hydroxyglutaric acid. Untreated patients develop bilateral lesions of basal ganglia resulting in a complex movement disorder with predominant dystonia in infancy and early childhood. The current pathomechanistic concept strongly focuses on imbalanced neuronal energy metabolism due to accumulating metabolites, whereas little is known about the pathomechanistic role of astrocytes, which are thought to be in constant metabolic crosstalk with neurons...
November 2, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29079116/a-frequently-asked-question-is-it-normal-not-to-feel-my-baby-s-movements-yet
#20
Hatice Akkaya, Barış Büke
BACKGROUND: This study aims to investigate average gestational week in which mothers feel their baby's movements for the first time, and the maternal-fetal factors affecting this time. METHODS: A total of 423 pregnant women between 11 and 25 weeks of gestation were included in this prospective study. The patient cohort was divided into three subgroups according to the gestational week in which fetal movements were felt for the first time by the pregnant women. The women who felt the first movement before 25th percentile value constituted Group 1; between 25th and 75th percentile value constituted Group 2; and beyond 75th percentile value constituted Group 3...
October 24, 2017: Journal of the Chinese Medical Association: JCMA
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