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Blue light therapy

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https://www.readbyqxmd.com/read/28930346/one-pot-solution-synthesis-of-shape-controlled-copper-selenide-nanostructures-and-their-potential-applications-in-photocatalysis-and-photothermal-therapy
#1
Xianwen Wang, Zhaohua Miao, Yan Ma, Huajian Chen, Haisheng Qian, Zhengbao Zha
Developing a facile and reliable method for the fabrication of transition metal chalcogenides is a vital and endless pursuit of scientific and technological disciplines. In this work, we develop a one-pot solution approach to obtain copper selenide nanostructures with different morphologies and crystal structures (Cu2Se nanoparticles, CuSe nanoplates and CuSe2 nanosheets). In comparison to previously reported methods, our method did not use expensive and very toxic raw materials. After detailed studies of reaction conditions, including temperature, reaction time, and feeding amount of surfactants and precursors, we found that the feeding ratio of precursors played a key role in the crystal structures and morphologies of the final products...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28881420/lethal-effect-of-photodynamic-treatment-on-persister-bacteria
#2
Oscar Juan Oppezzo, Ana Florencia Forte Giacobone
Persister bacteria tolerate bactericidal antibiotics due to transient and reversible phenotypic changes. Since these bacteria can limit the effectiveness of antibiotics to eradicate certain infections, their elimination is a relevant issue. Photodynamic therapy seems suitable for this purpose, but phenotypic tolerance to it has also been reported for Pseudomonas aeruginosa. To test whether any phenotypic feature could confer tolerance against both antibiotics and photoinactivation, survivors from exposures to light in the presence of methylene blue were treated with ofloxacin, an antibiotic effective on non-growing bacteria...
September 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28878330/the-impact-of-wavelengths-of-led-light-therapy-on-endothelial-cells
#3
Sabrina Rohringer, Wolfgang Holnthoner, Sidrah Chaudary, Paul Slezak, Eleni Priglinger, Martin Strassl, Karoline Pill, Severin Mühleder, Heinz Redl, Peter Dungel
Low level light therapy receives increasing interest in the fields of tissue regeneration and wound healing. Several in vivo studies demonstrated the positive effects of LLLT on angiogenesis. This study aimed to investigate the underlying properties in vitro by comparing the effects of light therapy by light emitting diodes of different wavelengths on endothelial cells in vitro. Human umbilical vein endothelial cells were treated with either 475 nm, 516 nm or 635 nm light. Control cells were not illuminated...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872842/core-shell-shell-multifunctional-nanoplatform-for-intracellular-tumor-related-mrnas-imaging-and-near-infrared-light-triggered-photodynamic-photothermal-synergistic-therapy
#4
Yao Cen, Wen-Jing Deng, Yuan Yang, Ru-Qin Yu, Xia Chu
A multifunctional nanoplatform, which generally integrates biosensing, imaging diagnosis, and therapeutic functions into a single nanoconstruct, has great important significance for biomedicine and nanoscience. Here, we developed a core-shell-shell multifunctional polydopamine (PDA) modified upconversion nanoplatform for intracellular tumor-related mRNAs detection and near-infrared (NIR) light triggered photodynamic and photothermal synergistic therapy (PDT-PTT). The nanoplatform was constructed by loading a silica shell on the hydrophobic upconversion nanoparticles (UCNPs) with hydrophilic photosensitizer methylene blue (MB) entrapped in it, and then modifying PDA shells through an in situ self-polymerization process, thus yielding a core-shell-shell nanoconstruct UCNP@SiO2-MB@PDA...
September 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28864891/cytotoxicity-of-targeted-her2-specific-phototoxins-based-on-flavoprotein-minisog-is-determined-by-the-rate-of-their-internalization
#5
O N Shilova, G M Proshkina, A V Ryabova, S M Deyev, R V Petrov
The concept of targeted therapy implies the development of bifunctional agents complementing the therapeutic module with a targeting one. A promising target for the delivery of imaging and/or toxic modules is the HER2 (ErbB2) receptor. Earlier, we have functionally characterized the targeted photosensitizers 4D5scFv-miniSOG and DARPin-miniSOG, causing the death of HER2-overexpressing cells when irradiated with blue light. However, the cytotoxicity of targeted toxins 4D5scFv-miniSOG and DARPin-miniSOG (both having functionally active targeted and cytotoxic modules in recombinant proteins) against human breast adenocarcinoma cells differs 5 times...
July 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28854417/effects-of-blue-light-emitting-diode-irradiation-on-the-proliferation-apoptosis-and-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells
#6
Ye Yuan, Gege Yan, Rui Gong, Lai Zhang, Tianyi Liu, Chao Feng, Weijie Du, Ying Wang, Fan Yang, Yuan Li, Shuyuan Guo, Fengzhi Ding, Wenya Ma, Elina Idiiatullina, Valentin Pavlov, Zhenbo Han, Benzhi Cai, Lei Yang
BACKGROUND/AIMS: Blue light emitting diodes (LEDs) have been proven to affect the growth of several types of cells. The effects of blue LEDs have not been tested on bone marrow-derived mesenchymal stem cells (BMSCs), which are important for cell-based therapy in various medical fields. Therefore, the aim of this study was to determine the effects of blue LED on the proliferation, apoptosis and osteogenic differentiation of BMSCs. METHODS: BMSCs were irradiated with a blue LED light at 470 nm for 1 min, 5 min, 10 min, 30 min and 60 min or not irradiated...
August 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28846164/cutaneous-sporotrichosis-treated-with-methylene-blue-daylight-photodynamic-therapy
#7
Ana Julia García-Malinis, Ana Milagro Beamonte, Luis Torres Sopena, Oscar García-Callen, Pilar Puertolas-Villacampa, Yolanda Gilaberte
Sporotrichosis is an infection caused by the dimorphic fungus,Sporothrix schenckii. Acquisition typically occurs via cutaneous inoculation with development of a localized cutaneous and/or lymphocutaneous infection. aPDT (antimicrobial photodynamic therapy) is a process that generates reactive oxygen species (ROS) in presence of a photosensitizer, visible light and oxygen which destroys fungal and bacterial cells(1). Daylight PDT (DL-PDT) uses the visible spectrum of daylight (400-750nm) for the activation of the photosensitizer instead of an artificial light source...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28836110/effects-of-photodynamic-therapy-on-the-growth-and-antifungal-susceptibility-of-scedosporium-and-lomentospora-spp
#8
Qiaoyun Lu, Yi Sun, Dingdan Tian, Shoubao Xiang, Lujuan Gao
Scedosporium and Lomentospora species are the second most frequent colonizing, allergenic, or invasive fungal pathogens in patients with cystic fibrosis, and are responsible for infections varying from cutaneous and subcutaneous tissue infections caused by traumatic inoculation to severe systemic diseases in immunocompromised patients. The clinical relevance of fungal airway colonization for individual patients harboring Scedosporium and Lomentospora species is still an underestimated issue. The high resistance of Scedosporium and Lomentospora species to antifungal drugs has highlighted the need for alternative treatment modalities, and antimicrobial photodynamic therapy may be one such alternative...
August 23, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28826733/periopathogens-differ-in-terms-of-the-susceptibility-to-toluidine-blue-o-mediated-photodynamic-inactivation
#9
Zuzanna Oruba, Przemysław Łabuz, Wojciech Macyk, Maria Chomyszyn Gajewska
BACKGROUND: The main goal of periodontal therapy is to eliminate the infection spreading in periodontium. Antimicrobial photodynamic therapy may be applied in order to eradicate pathogens remaining in periodontal tissues after conventional mechanical debridement, thus, improve the treatment results. The aim of this in vitro study was to evaluate the susceptibility of selected key periopathogens to toluidine blue O-mediated photodynamic inactivation and the influence of photosensitizer's concentration and light dose on the effectiveness of this process...
August 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28797828/gene-expression-profiling-of-fima-gene-encoding-fimbriae-among-clinical-isolates-of-porphyromonas-gingivalis-in-response-to-photo-activated-disinfection-therapy
#10
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: The endodontic infection therapy majorly aims to eradicate the microbial pathogens. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is an alternative antimicrobial modality used to control the microorganisms causing endodontic infections. Notably, microorganisms may be exposed to sub-lethal doses of PAD (sPAD), influencing microbial virulence. The present study assessed the effects of sPAD on expression profiling of the gene associated with the biofilm formation being the most essential virulence factor in Porphyromonas gingivalis strain cells that survive the photodynamic reatment in vivo...
August 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28793186/an-engineered-optogenetic-switch-for-spatiotemporal-control-of-gene-expression-cell-differentiation-and-tissue-morphogenesis
#11
Lauren Polstein, Mark Juhas, Gabi Hanna, Nenad Bursac, Charles A Gersbach
The precise spatial and temporal control of gene expression, cell differentiation, and tissue morphogenesis has widespread application in regenerative medicine and the study of tissue development. In this work, we applied optogenetics to control cell differentiation and new tissue formation. Specifically, we engineered an optogenetic "on" switch that provides permanent transgene expression following a transient dose of blue light illumination. To demonstrate its utility in controlling cell differentiation and reprogramming, we incorporated an engineered form of the master myogenic factor MyoD into this system in multipotent cells...
August 9, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28792728/environment-activatable-nanoprodrug-two-step-surveillance-in-the-anticancer-drug-release
#12
Sandipan Biswas, Joyjyoti Das, Shrabani Barman, Bhaskara Rao Pinninti, Tapas K Maiti, N D Pradeep Singh
Remedial cancer therapy deals with a large number of theranostic applications. However, systems, so far known, are only capable of single surveillance for both diagnostic and therapeutic modes of action. A nanosystem, which can be localized to the cancer and deliver the chemotherapeutic agent on demand, will provide effective therapeutic activity. Herein, we designed a single component nanoprodrug ANPD-X (Activatable Nano Pro-Drug-X) which indentified the tumor sites by fluorescent color change (signal 1, blue to green fluorescence) using H2O2-mediated oxidation of boronate fluorophore...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28790398/shedding-light-on-alzheimer-s-%C3%AE-amyloidosis-photosensitized-methylene-blue-inhibits-self-assembly-of-%C3%AE-amyloid-peptides-and-disintegrates-their-aggregates
#13
Byung Il Lee, Yoon Seok Suh, You Jung Chung, Kweon Yu, Chan Beum Park
Abnormal aggregation of β-amyloid (Aβ) peptides is a major hallmark of Alzheimer's disease (AD). In spite of numerous attempts to prevent the β-amyloidosis, no effective drugs for treating AD have been developed to date. Among many candidate chemicals, methylene blue (MB) has proved its therapeutic potential for AD in a number of in vitro and in vivo studies; but the result of recent clinical trials performed with MB and its derivative was negative. Here, with the aid of multiple photochemical analyses, we first report that photoexcited MB molecules can block Aβ42 aggregation in vitro...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783253/dual-stage-light-amplified-photodynamic-therapy-against-hypoxic-tumor-based-on-an-o2-self-sufficient-nanoplatform
#14
Li-Han Liu, Yao-Hui Zhang, Wen-Xiu Qiu, Lu Zhang, Fan Gao, Bin Li, Lu Xu, Jin-Xian Fan, Zi-Hao Li, Xian-Zheng Zhang
Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO2 ) with O2 self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, (1) O2 activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO2 with H2 O, resulting in accelerated O2 production. Accelerated O2 level further regulates hypoxic tumor microenvironment and in turn improves (1) O2 generation by MB under another long time irradiation...
August 7, 2017: Small
https://www.readbyqxmd.com/read/28778018/antibacterial-activity-and-antibiotic-modulating-potential-of-the-essential-oil-obtained-from-eugenia-jambolana-in-association-with-led-lights
#15
Nara L F Pereira, Pedro E A Aquino, José G A S Júnior, Janyketchuly S Cristo, Marcos A Vieira Filho, Flávio F Moura, Najla M N Ferreira, Maria K N Silva, Eloiza M Nascimento, Fabrina M A Correia, Francisco A B Cunha, Aline A Boligon, Henrique D M Coutinho, Jaime Ribeiro-Filho, Edinardo F F Matias, Maria I F Guedes
Bacterial resistance has risen as an important health problem with impact on the pharmaceutical industry because many antibiotics have become ineffective, which has affected their commercialization. The Brazilian biodiversity is marked by a vast variety of natural products with significant therapeutic potential, which could bring new perspectives in the treatment of infections caused by resistant microorganisms. The present study aimed to evaluate the antibacterial effect of the essential oil obtained from Eugenia jambolana (EjEO) using the method of microdilution method to determine the Minimum Inhibitory Concentration (MIC)...
July 26, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28776111/methylene-blue-mediated-photobiomodulation-on-human-osteoblast-cells
#16
Gamze Bölükbaşı Ateş, Ayşe Ak, Bora Garipcan, Murat Gülsoy
Photobiomodulation (PBM) and photodynamic therapy (PDT) are two major methods, which use light in medicine and dentistry. PBM uses low-level laser light to induce cell proliferation and activity. In contrast, PDT use laser light combined with a photosensitizer (PS) to cause cell death. Due to similar, not fully understood mechanisms and biphasic response of light, unexpected and complex outcomes may be observed. In the present study, the effect of 635 nm laser light, with power density 50 mW/cm(2), at three different energy densities (0...
August 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28770401/in-vitro-studies-to-evaluate-the-effect-of-varying-culture-conditions-and-ipl-fluencies-on-tenocyte-activities
#17
Jihad A M Alzyoud, Ilyas M Khan, Sarah G Rees
Tendons are dense, fibrous connective tissues which carry out the essential physiological role of transmitting mechanical forces from skeletal muscle to bone. From a clinical perspective, tendinopathy is very common, both within the sporting arena and amongst the sedentary population. Studies have shown that light therapy may stimulate tendon healing, and more recently, intense pulsed light (IPL) has attracted attention as a potential treatment modality for tendinopathy; however, its mechanism of action and effect on the tendon cells (tenocytes) is poorly understood...
August 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28765675/effect-of-antimicrobial-photodynamic-therapy-using-rose-bengal-and-blue-light-emitting-diode-on-porphyromonas-gingivalis-in-vitro-influence-of-oxygen-during-treatment
#18
Ayano Uekubo, Koichi Hiratsuka, Akira Aoki, Yasuo Takeuchi, Yoshimitsu Abiko, Yuichi Izumi
Aims: A combination of rose bengal (RB) and blue LED (BL) has emerged as a new technical modality for antimicrobial photodynamic therapy (a-PDT). The purpose of this study was to clarify the influence of oxygen on the antimicrobial effect of RB + BL treatment on Porphyromonas gingivalis in vitro.Materials and Methods:P. gingivalis cells were treated with RB, BL (450-470 nm; 1 W/cm(2), 5 s), or RB + BL under anaerobic/aerobic conditions. Cells were incubated anaerobically, and the cell density (OD600 nm) was measured after 6-48 h...
December 30, 2016: Laser Therapy
https://www.readbyqxmd.com/read/28763105/physiological-doses-of-red-light-induce-il-4-release-in-cocultures-between-human-keratinocytes-and-immune-cells
#19
Cheryl Leong, Paul L Bigliardi, Gopu Sriram, Veonice B Au, John Connolly, Mei Bigliardi-Qi
Phototherapy is routinely used for the treatment of various skin conditions and targeted therapy of superficial cancers. However, the molecular mechanisms behind their biological effects and the need for efficacy enhancing photosensitizers are not well addressed. Particularly, not much is known about the inherent effect of light from the visible spectrum on cytokine release and its downstream effects in keratinocytes and immune cells located in skin and therefore exposed to light. To address this, we delivered calibrated doses of well-defined light qualities (380 to 660 nm) to cocultures of human keratinocytes and macrophage/dendritic cells in the absence or presence of the commonly used photosensitizer 8-methoxypsoralen (8-MOP)...
August 1, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28763104/led-phototherapy-with-gelatin-sponge-promotes-wound-healing-in-mice
#20
Heng Zhang, Shupeng Liu, Xiangfei Yang, Na Chen, Fufei Pang, Zhenyi Chen, Tingyun Wang, Jianshe Zhou, Fuji Ren, Xiaoyin Xu, Taihao Li
Tiny but highly efficient, a light emitting diode (LED) can power a therapy device, such as a phototherapy device, and, at the same time, decrease the device's size requirements. In this study, a LED phototherapy device was designed to investigate the possible impact on wound healing using a mouse model and a cell line exposed to red and blue light. To enhance wound phototherapy, a gelatin sponge was fabricated. Results showed that the red and blue lights promoted cell growth and wound healing, while the blue light with a gelatin sponge protected the wound from infection in the early stages of wound healing...
August 1, 2017: Photochemistry and Photobiology
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