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Blue light therapy

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https://www.readbyqxmd.com/read/28797828/gene-expression-profiling-of-fima-gene-encoding-fimbriae-among-clinical-isolates-of-porphyromonas-gingivalis-in-response-to-photo-activated-disinfection-therapy
#1
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: The endodontic infection therapy majorly aims to eradicate the microbial pathogens. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is an alternative antimicrobial modality used to control the microorganisms causing endodontic infections. Notably, microorganisms may be exposed to sub-lethal doses of PAD (sPAD), influencing microbial virulence. The present study assessed the effects of sPAD on expression profiling of the gene associated with the biofilm formation being the most essential virulence factor in Porphyromonas gingivalis strain cells that survive the photodynamic reatment in vivo...
August 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28793186/an-engineered-optogenetic-switch-for-spatiotemporal-control-of-gene-expression-cell-differentiation-and-tissue-morphogenesis
#2
Lauren Polstein, Mark Juhas, Gabi Hanna, Nenad Bursac, Charles A Gersbach
The precise spatial and temporal control of gene expression, cell differentiation, and tissue morphogenesis has widespread application in regenerative medicine and the study of tissue development. In this work, we applied optogenetics to control cell differentiation and new tissue formation. Specifically, we engineered an optogenetic "on" switch that provides permanent transgene expression following a transient dose of blue light illumination. To demonstrate its utility in controlling cell differentiation and reprogramming, we incorporated an engineered form of the master myogenic factor MyoD into this system in multipotent cells...
August 9, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28792728/an-environment-activatable-nanoprodrug-two-step-surveillance-in-the-anticancer-drug-release
#3
Sandipan Biswas, Joyjyoti Das, Shrabani Barman, Bhaskara Rao Pinninti, Tapas K Maiti, N D Pradeep Singh
Remedial cancer therapy deals with a large number of theranostic applications. However, systems, so far known, are only capable of single surveillance for both diagnostic and therapeutic modes of actions. A nanosystem, which can be localized to the cancer and deliver the chemotherapeutic agent on demand, will provide effective therapeutic activity. Herein, we designed a single component nanoprodrug ANPD-X (Activatable Nano Pro-Drug-X) which indentified the tumor sites by fluorescent colour change (signal 1, blue to green fluorescence) using H2O2-mediated oxidation of boronate fluorophore...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28790398/shedding-light-on-alzheimer-s-%C3%AE-amyloidosis-photosensitized-methylene-blue-inhibits-self-assembly-of-%C3%AE-amyloid-peptides-and-disintegrates-their-aggregates
#4
Byung Il Lee, Yoon Seok Suh, You Jung Chung, Kweon Yu, Chan Beum Park
Abnormal aggregation of β-amyloid (Aβ) peptides is a major hallmark of Alzheimer's disease (AD). In spite of numerous attempts to prevent the β-amyloidosis, no effective drugs for treating AD have been developed to date. Among many candidate chemicals, methylene blue (MB) has proved its therapeutic potential for AD in a number of in vitro and in vivo studies; but the result of recent clinical trials performed with MB and its derivative was negative. Here, with the aid of multiple photochemical analyses, we first report that photoexcited MB molecules can block Aβ42 aggregation in vitro...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783253/dual-stage-light-amplified-photodynamic-therapy-against-hypoxic-tumor-based-on-an-o2-self-sufficient-nanoplatform
#5
Li-Han Liu, Yao-Hui Zhang, Wen-Xiu Qiu, Lu Zhang, Fan Gao, Bin Li, Lu Xu, Jin-Xian Fan, Zi-Hao Li, Xian-Zheng Zhang
Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO2 ) with O2 self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, (1) O2 activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO2 with H2 O, resulting in accelerated O2 production. Accelerated O2 level further regulates hypoxic tumor microenvironment and in turn improves (1) O2 generation by MB under another long time irradiation...
August 7, 2017: Small
https://www.readbyqxmd.com/read/28778018/antibacterial-activity-and-antibiotic-modulating-potential-of-the-essential-oil-obtained-from-eugenia-jambolana-in-association-with-led-lights
#6
Nara L F Pereira, Pedro E A Aquino, José G A S Júnior, Janyketchuly S Cristo, Marcos A Vieira Filho, Flávio F Moura, Najla M N Ferreira, Maria K N Silva, Eloiza M Nascimento, Fabrina M A Correia, Francisco A B Cunha, Aline A Boligon, Henrique D M Coutinho, Jaime Ribeiro-Filho, Edinardo F F Matias, Maria I F Guedes
Bacterial resistance has risen as an important health problem with impact on the pharmaceutical industry because many antibiotics have become ineffective, which has affected their commercialization. The Brazilian biodiversity is marked by a vast variety of natural products with significant therapeutic potential, which could bring new perspectives in the treatment of infections caused by resistant microorganisms. The present study aimed to evaluate the antibacterial effect of the essential oil obtained from Eugenia jambolana (EjEO) using the method of microdilution method to determine the Minimum Inhibitory Concentration (MIC)...
July 26, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28776111/methylene-blue-mediated-photobiomodulation-on-human-osteoblast-cells
#7
Gamze Bölükbaşı Ateş, Ayşe Ak, Bora Garipcan, Murat Gülsoy
Photobiomodulation (PBM) and photodynamic therapy (PDT) are two major methods, which use light in medicine and dentistry. PBM uses low-level laser light to induce cell proliferation and activity. In contrast, PDT use laser light combined with a photosensitizer (PS) to cause cell death. Due to similar, not fully understood mechanisms and biphasic response of light, unexpected and complex outcomes may be observed. In the present study, the effect of 635 nm laser light, with power density 50 mW/cm(2), at three different energy densities (0...
August 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28770401/in-vitro-studies-to-evaluate-the-effect-of-varying-culture-conditions-and-ipl-fluencies-on-tenocyte-activities
#8
Jihad A M Alzyoud, Ilyas M Khan, Sarah G Rees
Tendons are dense, fibrous connective tissues which carry out the essential physiological role of transmitting mechanical forces from skeletal muscle to bone. From a clinical perspective, tendinopathy is very common, both within the sporting arena and amongst the sedentary population. Studies have shown that light therapy may stimulate tendon healing, and more recently, intense pulsed light (IPL) has attracted attention as a potential treatment modality for tendinopathy; however, its mechanism of action and effect on the tendon cells (tenocytes) is poorly understood...
August 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28765675/effect-of-antimicrobial-photodynamic-therapy-using-rose-bengal-and-blue-light-emitting-diode-on-porphyromonas-gingivalis-in-vitro-influence-of-oxygen-during-treatment
#9
Ayano Uekubo, Koichi Hiratsuka, Akira Aoki, Yasuo Takeuchi, Yoshimitsu Abiko, Yuichi Izumi
Aims: A combination of rose bengal (RB) and blue LED (BL) has emerged as a new technical modality for antimicrobial photodynamic therapy (a-PDT). The purpose of this study was to clarify the influence of oxygen on the antimicrobial effect of RB + BL treatment on Porphyromonas gingivalis in vitro.Materials and Methods:P. gingivalis cells were treated with RB, BL (450-470 nm; 1 W/cm(2), 5 s), or RB + BL under anaerobic/aerobic conditions. Cells were incubated anaerobically, and the cell density (OD600 nm) was measured after 6-48 h...
December 30, 2016: Laser Therapy
https://www.readbyqxmd.com/read/28763105/physiological-doses-of-red-light-induce-il-4-release-in-co-cultures-between-human-keratinocytes-and-immune-cells
#10
Cheryl Leong, Paul L Bigliardi, Gopu Sriram, Bijin Veonice Au, John Connolly, Mei Bigliardi-Qi
Phototherapy is routinely used for the treatment of various skin conditions and targeted therapy of superficial cancers. However, the molecular mechanisms behind their biological effects and the need for efficacy enhancing photosensitizers are not well addressed. Particularly, not much is known about the inherent effect of light from the visible spectrum on cytokine release and its downstream effects in keratinocytes and immune cells located in skin and therefore exposed to light. To address this, we delivered calibrated doses of well-defined light qualities (380 to 660 nm) to co-cultures of human keratinocytes and macrophage/dendritic cells in the absence or presence of the commonly used photosensitizer 8-methoxypsoralen (8-MOP)...
August 1, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28763104/led-phototherapy-with-gelatin-sponge-promotes-wound-healing-in-mice
#11
Heng Zhang, Shupeng Liu, Xiangfei Yang, Na Chen, Fufei Pang, Zhenyi Chen, Tingyun Wang, Jianshe Zhou, Fuji Ren, Xiaoyin Xu, Taihao Li
Tiny but highly efficient, a light emitting diode (LED) can power a therapy device, such as a phototherapy device, and, at the same time, decrease the device's size requirements. In this study, a LED phototherapy device was designed to investigate the possible impact on wound healing using a mouse model and a cell line exposed to red and blue light. To enhance wound phototherapy, a gelatin sponge was fabricated. Results showed that the red and blue lights promoted cell growth and wound healing, while the blue light with a gelatin sponge protected the wound from infection in the early stages of wound healing...
August 1, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28748760/visible-light-therapy-molecular-mechanisms-and-therapeutic-opportunities
#12
Zandra C Félix Garza, Matthias Born, Peter A J Hilbers, Natal A W van Riel, Joerg Liebmann
Visible light is absorbed by photoacceptors in pigmented and non-pigmented mammalian cells, activating signaling cascades and downstream mechanisms that lead to the modulation of cellular processes. Most studies have investigated the molecular mechanisms and therapeutic applications of UV and the red to near infrared regions of the visible spectrum. However, considerably less effort has been dedicated to the UV-free blue part of the spectrum. In this review we discuss the current advances in the understanding of the molecular photoacceptors, downstream signaling mechanisms and the corresponding therapeutic opportunities in the context of inflammatory skin conditions of blue light photoreception in mammalian cells...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28744057/the-effects-of-treatment-room-lighting-color-on-time-perception-and-emotion
#13
Seulki Han, Daehee Lee
[Purpose] The purpose of this study was to investigate the perceived treatment times and emotional reactions under different light colors in the treatment room. [Subjects and Methods] Subjects in this study were 20 healthy young students in their 20s. Under each lighting condition (blue, red, white, and yellow) differentiated by color, each subject laid on a therapeutic bed and underwent ultrasound therapy. Subjects were instructed to press a stopwatch every 1 minute, for a total of 5 times, after therapy started according to their perception of time while the stopwatch's time indicator was blocked...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28726387/aryl-substituted-ruthenium-ii-complexes-a-strategy-for-enhanced-photocleavage-and-efficient-dna-binding
#14
Felipe Diógenes Abreu, Tercio de F Paulo, Marcelo H Gehlen, Rômulo A Ando, Luiz G F Lopes, Ana Cláudia S Gondim, Mayron A Vasconcelos, Edson H Teixeira, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho
Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and great reactive oxygen species (ROS) photogeneration: two properties that are not easily found in the same molecule. To prepare such new agents, we synthesized two new ruthenium complexes that combine an efficient DNA binding moiety (dppz ligand) together with naphthyl-modified (1) and anthracenyl-modified (2) bipyridine as a strong ROS generator bound to a ruthenium complex...
August 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28708527/artificially-extended-photoperiod-administered-to-pre-partum-mares-via-blue-light-to-a-single-eye-observations-on-gestation-length-foal-birth-weight-and-foal-hair-coat-at-birth
#15
Margaret B Nolan, Caroline M Walsh, Noelle Duff, Conor McCrarren, Ralph L Prendergast, Barbara A Murphy
In seasonally breeding animals, photoperiod perception is crucial for timing of important physiological events. In the horse, long day photoperiod influences the onset of ovulation and cyclicity, shedding of the heavier winter coat and the timing of parturition. In this compilation of studies, conducted across three breeding seasons and two countries, the impact of artificially extended day length was investigated on gestation length, foal birth weight and foal hair coat at birth. The light therapy was administered to pre-partum mares via mobile head worn masks which provided short wavelength blue light to a single eye...
June 9, 2017: Theriogenology
https://www.readbyqxmd.com/read/28706756/impact-of-vital-dyes-on-cell-viability-and-transduction-efficiency-of-aav-vectors-used-in-retinal-gene-therapy-surgery-an-in-vitro-and-in-vivo-analysis
#16
Anna P Salvetti, Maria I Patrício, Alun R Barnard, Harry O Orlans, Doron G Hickey, Robert E MacLaren
PURPOSE: Treatment of inherited retinal degenerations using adeno-associated viral (AAV) vectors involves delivery by subretinal injection. In the latter stages, alteration of normal anatomy may cause difficulty in visualizing the retinotomy, retinal detachment extension, and vector diffusion. Vital dyes may be useful surgical adjuncts, but their safety and impact on AAV transduction are largely unknown. METHODS: The effects of Sodium Fluorescein (SF), Membrane Blue (MB), and Membrane Blue Dual (DB) at a range of dilutions were assessed on human embryonic kidney cells in vitro using an AAV2-green fluorescent protein (GFP) reporter at different multiplicities of infection...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28701797/antimicrobial-effect-of-blue-light-using-porphyromonas-gingivalis-pigment
#17
Ayaka Yoshida, Haruka Sasaki, Toshizo Toyama, Mitsunori Araki, Jun Fujioka, Koichi Tsukiyama, Nobushiro Hamada, Fumihiko Yoshino
The development of antibiotics cannot keep up with the speed of resistance acquired by microorganisms. Recently, the development of antimicrobial photodynamic therapy (aPDT) has been a necessary antimicrobial strategy against antibiotic resistance. Among the wide variety of bacteria found in the oral flora, Porphyromonas gingivalis (P. gingivalis) is one of the etiological agents of periodontal disease. aPDT has been studied for periodontal disease, but has risks of cytotoxicity to normal stained tissue. In this study, we performed aPDT using protoporphyrin IX (PpIX), an intracellular pigment of P...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699222/in-vitro-fungicidal-effects-of-methylene-blue-at-625-nm
#18
J Stephen Guffey, William Payne, Wilson Roegge
The aim of the study is to confirm the effectiveness of photodynamic therapy (PDT) as a significant inhibitor of Trichophyton rubrum (T. rubrum) and to determine the most appropriate dose and rate of delivery. Trichophyton rubrum is the most common dermatophyte worldwide, responsible for the majority of superficial fungal infections. The traditional treatment of T. rubrum has known adverse effects. An alternative treatment is warranted. Photosensitised T. rubrum specimens were treated with 625-nm light at doses of 3, 12, 24, 40 and 60 J/cm(2) ...
July 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28673742/blue-light-potentiates-neurogenesis-induced-by-retinoic-acid-loaded-responsive-nanoparticles
#19
Tiago Santos, Raquel Ferreira, Emanuel Quartin, Carlos Boto, Cláudia Saraiva, José Bragança, João Peça, Cecília Rodrigues, Lino Ferreira, Liliana Bernardino
Neurogenic niches constitute a powerful endogenous source of new neurons that can be used for brain repair strategies. Neuronal differentiation of these cells can be regulated by molecules such as retinoic acid (RA) or by mild levels of reactive oxygen species (ROS) that are also known to upregulate RA receptor alpha (RARα) levels. Data showed that neural stem cells from the subventricular zone (SVZ) exposed to blue light (405nm laser) transiently induced NADPH oxidase-dependent ROS, resulting in β-catenin activation and neuronal differentiation, and increased RARα levels...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28666974/application-of-photodynamic-therapy-laser-therapy-and-a-cellulose-membrane-for-calcaneal-pressure-ulcer-treatment-in-a-diabetic-patient-a-case-report
#20
Luciano Pereira Rosa, Francine Cristina da Silva, Regiane Lima Vieira, Beatriz Rocha Tanajura, Alana Gonçalves da Silva Gusmão, Janeide Muritiba de Oliveira, Nathalia Aparecida Campanário Dos Santos, Vanderlei Salvador Bagnato
Diabetes mellitus is a metabolic disorder in which a person has high blood glucose levels due to inadequate insulin production by the pancreas. Wounds in these individuals cannot heal properly over time due to circulatory changes that hinder and stagnate the healing process. We report the case of an 82-year-old female type 2 diabetes mellitus carrier, presenting to clinical-dermatological examination pressure ulcer (PU) in the right calcaneus region. The patient was treated with photodynamic therapy using curcumin and blue light-emitting diodes (LEDs), laser therapy, and the application of a cellulose membrane in order to promote ulcer decontamination by local action, accelerate wound healing, and maintain favorable conditions of asepsis and moisture, respectively...
June 27, 2017: Photodiagnosis and Photodynamic Therapy
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