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https://www.readbyqxmd.com/read/28088439/antimicrobial-activity-of-photodynamic-therapy-in-combination-with-colistin-against-a-pan-drug-resistant-acinetobacter-baumannii-isolated-from-burn-patient
#1
Ebrahim Boluki, Hossein Kazemian, Hadi Peeridogaheh, Mohammad Yousef Alikhani, Sima Shahabi, Leili Beytollahi, Roghayeh Ghorbanzadeh
Nosocomially-acquired multi-, extensively-, and pandrug resistant (MDR, XDR, and PDR) strains of microorganisms such as Acinetobacter baumannii remain a serious cause of infection and septic mortality in burn patients. Treatment of patients with nosocomial burn wound infections is often complicated by drug-resistant strains of A. baumannii. Today, many researchers are focusing on the investigation of novel non-antibiotic strategies such as photodynamic therapy (PDT). We report a new PDT strategy that suppresses colistin resistance in PDR A...
January 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28087479/synthesis-and-characterization-of-gold-nanostructured-chorin-e6-for-photodynamic-therapy
#2
L Vieira, M L Castilho, I Ferreira, J Ferreira-Strixino, K C Hewitt, L Raniero
Photodynamic therapy is an alternative treatment for cancer based on cellular uptake of a photosensitizer, illuminated with an appropriate wavelength in the presence of oxygen. A cascade of reactions generates reactive oxygen species leading to cell death. Using carbodiimide chemistry, chlorin e6 (Ce6) was covalently bonded to thiourea, and (via the sulphur end group) to gold nanoparticles (AuNPs), forming the Ce6-AuNP complex. Ce6 absorbs in the range 650-680nm, where the coefficient of biological tissue absorption is low (part of the therapeutic window), which is ideal for biological application...
January 10, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28068182/improvement-of-antibacterial-efficacy-through-synergistic-effect-in-photodynamic-therapy-based-on-thiazinium-chromophores-against-planktonic-and-biofilm-associated-periodontopathogens
#3
Eva-Maria Decker, Valentin Bartha, Christiane von Ohle
OBJECTIVE: Aim of the study was to improve the antibacterial efficacy of toluidine blue (TBO)/methylene blue (MB)-mediated photodynamic systems with light-emitting diode (LED) or laser irradiation administered to planktonic and biofilm-associated periodontopathogens. BACKGROUND DATA: Antibacterial photodynamic therapy (PDT) is a common, noninvasive adjunctive clinical method to inactivate microorganisms. So far, the disadvantage of this method has been its limited effectiveness in eliminating pathogens...
January 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28061356/clinical-differences-in-autofluorescence-between-viable-and-nonvital-bone-a-case-report-with-histopathologic-evaluation-performed-on-medication-related-osteonecrosis-of-the-jaws
#4
Ilaria Giovannacci, Marco Meleti, Domenico Corradi, Paolo Vescovi
Medication-related osteonecrosis of the jaws (MRONJ) is an adverse side effect of several drug therapies, including bisphosphonates (BPs). Osteonecrosis of the jaw specifically related to BP therapy is usually referred to using the acronym BRONJ. However, no consensus has yet been reached regarding the most appropriate management of BRONJ. The greatest success rates have been recorded with surgical removal of necrotic bone. In particular, erbium:yttrium-aluminum-garnet (Er:YAG) laser-assisted surgery has shown significantly better results than conventional surgical approaches...
December 15, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28048857/su-f-t-684-analysis-of-cherenkov-excitation-in-tissue-and-the-feasibility-of-cherenkov-excited-photodynamic-therapy
#5
Sara L Saunders, Adam K Glaser, Jacqueline M Andreozzi, Brian W Pogue
PURPOSE: The irradiation of photodynamic agents with radiotherapy beams has been demonstrated to enhance tumor killing in various studies, and one proposed mechanism is the optical fluence of Cherenkov emission activating the photosensitizer. This mechanism is explored in Monte Carlo simulations of fluence as well as laboratory measurements of fluence and radical oxygen species. METHODS: Simulations were completed using GAMOS/GEANT4 with a 6 MV photon beam in tissue...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047541/we-fg-bra-01-cancer-treatment-utilizing-photo-activation-of-psoralen-with-kv-x-rays
#6
M Oldham, S Yoon, B Meng, Z Fathi, W Beyer, J Adamson, D Alcorta, T Osada, K Lyerly, M Dewhirst, P Fecci, H Walder, N Spector
PURPOSE: This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with immunogenic anti-cancer potential. Psoralen therapies have been limited due to the requirement for psoralen activation by UVA light. X-PACT solves this challenge by activating psoralen with UV light emitted from novel non-tethered phosphors (co-incubated with psoralen) that absorb x-rays and reradiate (phosphoresce) at UV wavelengths...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040502/a-comparison-between-effect-of-photodynamic-therapy-by-led-and-calcium-hydroxide-therapy-for-root-canal-disinfection-against-enterococcus-faecalis-a-randomized-controlled-trial
#7
Mohammad Asnaashari, Hengameh Ashraf, Afsaneh Rahmati, Neda Amini
BACKGROUND: Insufficient root canal disinfection is one of the main reasons for persistent periapical pathology. Photodynamic therapy (PDT) has been proven effective in disinfecting infected root canals. The aim of this study was to evaluate the antimicrobial effect of photo activated disinfection (PAD) when using toluidine blue as photosensitizer and a LED lamp after the conventional treatment, and comparing it with calcium hydroxide therapy in vivo. METHODS: This clinical trial includes 20 patients with molars requiring endodontic retreatment...
December 28, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28026929/near-infrared-quantum-dot-and-89-zr-dual-labeled-nanoparticles-for-in-vivo-cerenkov-imaging
#8
Yiming Zhao, Travis M Shaffer, Sudeep Das, Carlos Pérez-Medina, Willem J M Mulder, Jan Grimm
Cerenkov luminescence (CL) is an emerging imaging modality that utilizes the light generated during the radioactive decay of many clinical used isotopes. Although it is increasingly used for background-free imaging and deep tissue photodynamic therapy, in vivo applications of CL suffer from limited tissue penetration. Here, we propose to use quantum dots (QDs) as spectral converters that can transfer the CL UV-blue emissions to near-infrared light that is less scattered or absorbed in vivo. Experiments on tissue phantoms showed enhanced penetration depth and increased transmitted intensity for CL in the presence of near-infrared (NIR) QDs...
January 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28024357/controllable-co-release-following-near-infrared-light-induced-cleavage-of-iron-carbonyl-derivatized-prussian-blue-nanoparticles-for-co-assisted-synergistic-treatment
#9
Wei-Peng Li, Chia-Hao Su, Ling-Chuan Tsao, Chun-Ting Chang, Ya-Ping Hsu, Chen-Sheng Yeh
Carbon monoxide (CO) causes the dysfunction of mitochondria to induce the apoptosis of cancer cells giving a promising choice as an emerging treatment. The currently reported CO-based complexes still suffer from many limitations. Synthesis of CO-release carriers in the manner of on-demand control is highly anticipated. In this study, we present a near-infrared (NIR) light-responsive CO-delivery nanocarrier, a PEGylated iron carbonyl derivatized Prussian blue (PB) nanoparticle (NP). Taking the structural characteristic containing Fe(3+)-N≡C-Fe(2+) unit, the -CN(-) served as the active sites for the coordination of iron carbonyl, while the surface Fe sites chelated with the amine-functionalized polyethylene glycol (NH2-PEG6000-NH2) to yield PEGylated PB NPs carrying CO...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28003770/advances-in-the-management-of-erythropoietic-protoporphyria-role-of-afamelanotide
#10
REVIEW
Ashley M Lane, Jerome T McKay, Herbert L Bonkovsky
Erythropoietic protoporphyria (EPP) and the phenotypically similar disease X-linked protoporphyria (XLPP) are inherited cutaneous porphyrias characterized clinically by acute non-blistering photosensitivity, intolerance to sunlight, and significantly reduced quality of life. They are due to marked overproduction of protoporphyrin (PP) chiefly by erythroblasts and reticulocytes. In EPP, the underlying genetic defect is in the ferrochelatase gene, which encodes the final enzyme in the heme synthetic pathway. In XLPP, the genetic defect is a gain-of-function mutation, usually a four-base deletion, in the gene that encodes the enzyme 5-aminolevulinic acid synthase-2, the first and rate-controlling enzyme of heme synthesis in developing red blood cells...
2016: Application of Clinical Genetics
https://www.readbyqxmd.com/read/27970515/the-cost-effectiveness-of-blue-light-therapy-vs-fixed-combination-of-calcipotriol-and-betamethasone-dipropionate-gel-in-the-treatment-of-mild-to-moderate-psoriasis
#11
A Ansaripour, H B Thio, R Maessen, W K Redekop
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27933825/plasmon-enhanced-photodynamic-cancer-therapy-by-upconversion-nanoparticles-conjugated-with-au-nanorods
#12
Chieh-Wei Chen, Yung-Chieh Chan, Michael Hsiao, Ru-Shi Liu
Photodynamic therapy (PDT) based on photosensitizers (PSs) constructed with nanomaterials has been widely applied to treat cancer. This therapy is characterized by an improved PS accumulation in tumor regions. However, challenges, such as short penetration depth of light and low extinction coefficient of PSs, limit PDT applications. In this study, a nanocomposite consisting of NaYF4:Yb/Er upconversion nanoparticles (UCPs) conjugated with gold nanorods (Au NRs) was developed to improve the therapeutic efficiency of PDT...
November 30, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27904491/intravenous-transplantation-of-mouse-embryonic-stem-cells-attenuates-demyelination-in-an-icr-outbred-mouse-model-of-demyelinating-diseases
#13
Kidsadagon Pringproa, Anucha Sathanawongs, Chananthida Khamphilai, Sarocha Sukkarinprom, Apichart Oranratnachai
Induction of demyelination in the central nervous system (CNS) of experimental mice using cuprizone is widely used as an animal model for studying the pathogenesis and treatment of demyelination. However, different mouse strains used result in different pathological outcomes. Moreover, because current medicinal treatments are not always effective in multiple sclerosis patients, so the study of exogenous cell transplantation in an animal model is of great importance. The aims of the present study were to establish an alternative ICR outbred mouse model for studying demyelination and to evaluate the effects of intravenous cell transplantation in the present developed mouse model...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27867727/optical-lens-microneedle-array-for-percutaneous-light-delivery
#14
Moonseok Kim, Jeesoo An, Ki Su Kim, Myunghwan Choi, Matjaž Humar, Sheldon J J Kwok, Tianhong Dai, Seok Hyun Yun
The limited penetration depth of light in skin tissues is a practical bottleneck in dermatologic applications of light-induced therapies, including anti-microbial blue light therapy and photodynamic skin cancer therapy. Here, we demonstrate a novel device, termed optical microneedle array (OMNA), for percutaneous light delivery. A prototype device with a 11 by 11 array of needles at a spacing of 1 mm and a length of 1.6 mm was fabricated by press-molding poly-(lactic acid) (PLA) polymers. The device also incorporates a matched microlens array that focuses the light through the needle tips at specific points to achieve an optimal intensity profile in the tissue...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27851015/1379-blue-light-therapy-modulates-the-systemic-response-to-sepsis-in-mice-and-humans
#15
Anthony Lewis, Du Yuan, Xianghong Zhang, Richard Collage, Paul Waltz, Brian Zuckerbraun, Derek Angus, Matthew Rosengart
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27835685/light-tnfsf14-increases-the-survival-and-proliferation-of-human-bone-marrow-derived-mesenchymal-stem-cells
#16
Sook-Kyoung Heo, Eui-Kyu Noh, Gi-Dong Gwon, Jeong Yi Kim, Jae-Cheol Jo, Yunsuk Choi, SuJin Koh, Jin Ho Baek, Young Joo Min, Hawk Kim
LIGHT (HVEM-L, TNFSF14, or CD258), an entity homologous to lymphotoxins, with inducible nature and the ability to compete with herpes simplex virus glycoprotein D for herpes virus entry mediator (HVEM)/tumor necrosis factor (TNF)-related 2, is a member of the TNF superfamily. It is expressed as a homotrimer on activated T cells and dendritic cells (DCs), and has three receptors: HVEM, LT-β receptor (LTβR), and decoy receptor 3 (DcR3). So far, three receptors with distinct cellular expression patterns are known to interact with LIGHT...
2016: PloS One
https://www.readbyqxmd.com/read/27827890/in-vitro-photodynamic-effect-of-phycocyanin-against-breast-cancer-cells
#17
Subramaniyan Bharathiraja, Hansu Seo, Panchanathan Manivasagan, Madhappan Santha Moorthy, Suhyun Park, Jungwan Oh
C-phycocyanin, a natural blue-colored pigment-protein complex was explored as a novel photosensitizer for use in low-level laser therapy under 625-nm laser illumination. C-phycocyanin produced singlet oxygen radicals and the level of reactive oxygen species (ROS) were raised in extended time of treatment. It did not exhibit any visible toxic effect in the absence of light. Under 625-nm laser irradiation, c-phycocyanin generated cytotoxic stress through ROS induction, which killed MDA-MB-231 breast cancer cells depending on concentrations...
November 3, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27810128/novel-folic-acid-conjugated-fe3o4-zno-hybrid-nanoparticles-for-targeted-photodynamic-therapy
#18
Kunal Patel, Behin Sundara Raj, Yan Chen, Xia Lou
A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produced nano-PSs, due to the charge recombination via electron trapping by dissolved Fe(3+). A time and dose dependant toxicity associated with the nano-PSs was observed upon exposure to human epithelial colorectal adenocarcinoma (Caco-2) cells in the dark...
October 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27809305/chronic-activation-of-the-d156a-point-mutant-of-channelrhodopsin-2-signals-apoptotic-cell-death-the-good-and-the-bad
#19
Michael Perny, Lukas Muri, Heather Dawson, Sonja Kleinlogel
Channelrhodopsin-2 (ChR2) has become a celebrated research tool and is considered a promising potential therapeutic for neurological disorders. While making its way into the clinic, concerns about the safety of chronic ChR2 activation have emerged; in particular as the high-intensity blue light illumination needed for ChR2 activation may be phototoxic. Here we set out to quantify for the first time the cytotoxic effects of chronic ChR2 activation. We studied the safety of prolonged illumination on ChR2(D156A)-expressing human melanoma cells as cancer cells are notorious for their resistance to killing...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27777143/the-influence-of-photodynamic-therapy-with-5-aminolevulinic-acid-on-senescent-skin-cancer-cells
#20
Mantas Grigalavicius, Marina Juraleviciute, Mateusz Kwitniewski, A Juzeniene
BACKGROUND: Senescent cells, which are resistant to apoptosis, accumulate with age and after ultraviolet (UV) radiation, chemotherapy and radiation therapy. Preventing or eliminating senescent cells may be crucial for protection against skin cancer development and improving tumour treatment. The aim of the present study was to investigate the potential of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) to induce senescence in skin cancer cells and to eliminate senescent cells induced by chemotherapy (bleomycin) or UVA (315-400nm) exposure...
October 21, 2016: Photodiagnosis and Photodynamic Therapy
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