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https://www.readbyqxmd.com/read/28301624/photodynamic-therapy-effectively-treats-actinic-keratoses-without-pre-illumination-incubation-time
#1
Jessica Gandy, Brian Labadie, Dina Bierman, Christopher Zachary
<p>BACKGROUND: Actinic keratoses (AKs) are dysplastic lesions of the epidermis that have the potential to progress to non-melanoma skin cancers (NMSC). Traditional photodynamic therapy (PDT) requires a pre-illumination incubation time, which adds to overall in-office time and has been linked to pain. Our group has found a novel protocol to effectively treat AKs with PDT that eliminates the pre-illumination incubation period and uses 2 back-to-back cycles of 16 minute 40 seconds.</p> <p>METHODS: The patient was prepped with soapy water and isopropyl alcohol, and thick AKs were descaled with a curette...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300724/methylene-blue-curcumin-and-ion-pairing-nanoparticles-effects-on-photodynamic-therapy-of-mda-mb-231-breast-cancer-cell
#2
Reza Hosseinzadeh, Khatereh Khorsandi
PURPOSE: The aim of current study was to use methylene blue-curcumin ion pair nanoparticles and single dyes as photosensitizer for comparison of photodynamic therapy (PDT) efficacy on MDA-MB-231 cancer cells, also various light sources effect on activation of photosensitizer (PS) was considered. METHOD: Ion pair nanoparticles were synthesized using opposite charge ions precipitation and lyophilized. The PDT experiments were designed and the effect of PSs and light sources (Red LED (630nm; power density: 30mWcm(-2)) and blue LED (465nm; power density: 34mWcm(-2))) on the human breast cancer cell line were examined...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28298203/methylene-blue-photodynamic-therapy-induces-selective-and-massive-cell-death-in-human-breast-cancer-cells
#3
Ancély F Dos Santos, Letícia F Terra, Rosangela A M Wailemann, Talita C Oliveira, Vinícius de Morais Gomes, Marcela Franco Mineiro, Flávia Carla Meotti, Alexandre Bruni-Cardoso, Maurício S Baptista, Leticia Labriola
BACKGROUND: Breast cancer is the main cause of mortality among women. The disease presents high recurrence mainly due to incomplete efficacy of primary treatment in killing all cancer cells. Photodynamic therapy (PDT), an approach that causes tissue destruction by visible light in the presence of a photosensitizer (Ps) and oxygen, appears as a promising alternative therapy that could be used adjunct to chemotherapy and surgery for curing cancer. However, the efficacy of PDT to treat breast tumours as well as the molecular mechanisms that lead to cell death remain unclear...
March 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28288450/laser-treatment-of-tattoos-basic-principles
#4
Wolfgang Bäumler
Tattooing has become very popular worldwide during the past decades, and millions of people have one or many tattoos at different anatomical sites. The color of tattoos is mainly black, followed by red, green, blue, and other colors. A part of the tattooed people regret tattooing or have permanent problems with tattoos and therefore seek for tattoo removal. Tattoos consist of solid pigment particles in the skin. Thus, tattoo removal requires fragmentation of these permanently incorporated particles. The gold standard of tattoo removal is laser therapy...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28274357/laser-and-light-based-treatments-of-acne-and-acne-scarring
#5
Macrene Alexiades
The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28260713/a-case-of-gastric-type-adenoma-with-chief-cell-and-parietal-cell-differentiation-surrounded-by-complete-intestinal-metaplasia
#6
Ryutaro Furukawa, Tsuneo Oyama, Akiko Takahashi, Nobukazu Yorimitsu, Tadakazu Shimoda, Hiroyoshi Ota, Satoshi Shiozawa
A man in his 70s received Helicobacter pylori eradication therapy after endoscopic submucosal dissection (ESD) of the stomach. A small, yellowish, protuberant lesion was later observed on the anterior wall of the lower body of the stomach on surveillance esophagogastroduodenoscopy. Narrow band imaging-magnified endoscopy showed an irregular pit and net-like vascular pattern, with the background mucosa having a light blue crest pattern. A biopsy was performed, which led to a diagnosis of adenoma with a gastric phenotype, so repeat ESD was performed...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28259957/photodynamic-inactivation-of-fibroblasts-and-inhibition-of-staphylococcus%C3%A2-epidermidis-adhesion-and-biofilm-formation-by-toluidine-blue-o
#7
Xin Li, Zizhong Liu, Houfang Liu, Xi Chen, Yue Liu, Honglue Tan
Treating skin and soft tissue infections of severe limb traumas can be challenging. Crucial concerns focus on inhibiting biofilm formation by antibiotic‑resistant bacteria, and preventing scar formation by fibroblastic hyperproliferation. The local use of toluidine blue O (TBO)‑mediated photodynamic therapy (PDT) may be a promising strategy for treating such lesions. The present study used Staphylococcus epidermidis (strain ATCC 35984) to assess the effects of TBO‑PDT on bacterial adherence and biofilm formation, using confocal laser scanning microscopy (CLSM), tissue culture plating (TCP) and scanning electron microscopy (SEM)...
February 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28254338/controlled-co-release-of-doxorubicin-and-reactive-oxygen-species-for-synergistic-therapy-by-nir-remote-triggered-nanoimpellers
#8
Beibei Hou, Weitao Yang, Chunhong Dong, Bin Zheng, Ying Zhang, Jing Wu, Hanjie Wang, Jin Chang
How to encapsulate and transport the payload of multiple therapeutic compounds avoiding premature leakage, and simultaneously co-release them rapidly at specific lesions still remains the major concern in clinic. Herein, we designed the UCN@mSiO2-(Azo+RB) (azobenzene groups and Rose Bengal) nanoimpellers, which used the multicolor-emission capability of the core-shell upconverting nanoparticles (UCNs) at a single excitation wavelength to co-release anticarcinogen doxorubicin (Dox) and reactive oxygen species (ROS) for combined chemotherapy and photodynamic therapy (PDT)...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28241491/complexing-methylene-blue-with-phosphorus-dendrimers-to-increase-photodynamic-activity
#9
Monika Dabrzalska, Anna Janaszewska, Maria Zablocka, Serge Mignani, Jean Pierre Majoral, Barbara Klajnert-Maculewicz
The efficiency of photodynamic therapy is limited mainly due to low selectivity, unfavorable biodistribution of photosensitizers, and long-lasting skin sensitivity to light. However, drug delivery systems based on nanoparticles may overcome the limitations mentioned above. Among others, dendrimers are particularly attractive as carriers, because of their globular architecture and high loading capacity. The goal of the study was to check whether an anionic phosphorus dendrimer is suitable as a carrier of a photosensitizer-methylene blue (MB)...
February 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28241315/development-of-a-chromatic-pupillography-protocol-for-the-first-gene-therapy-trial-in-patients-with-cnga3-linked-achromatopsia
#10
Jolanta Lisowska, Lukasz Lisowski, Carina Kelbsch, Fumiatsu Maeda, Paul Richter, Susanne Kohl, Ditta Zobor, Torsten Strasser, Krunoslav Stingl, Eberhart Zrenner, Tobias Peters, Helmut Wilhelm, M Dominik Fischer, Barbara Wilhelm
Purpose: To establish a feasible and sensitive pupillographic protocol to assess outer and inner retinal function for the first gene therapy trial in achromatopsia patients (ACHM) with mutations in CNGA3. Methods: Twenty-seven CNGA3-ACHM patients and 22 age-matched control subjects were tested using chromatic pupillography. Three different protocols were established to assess the pupillary light reflex parameters and to create the final protocol. In the individual protocols, various stimulus parameters (i...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28237426/the-role-of-the-human-visual-cortex-in-assessment-of-the-long-term-durability-of-retinal-gene-therapy-in-follow-on-rpe65-clinical-trial-patients
#11
Manzar Ashtari, Elena S Nikonova, Kathleen A Marshall, Gloria J Young, Puya Aravand, Wei Pan, Gui-Shuang Ying, Aimee E Willett, Mani Mahmoudian, Albert M Maguire, Jean Bennett
PURPOSE: Gene therapy (GT) has offered immense hope to individuals who are visually impaired because of RPE65 mutations. Although GT has shown great success in clinical trials enrolling these individuals, evidence for stability and durability of this treatment over time is still unknown. Herein we explored the value of functional magnetic resonance imaging (fMRI) as an objective measure to assess independently the longevity of retinal GT. DESIGN: Individuals with RPE65 mutations who underwent GT in their worse-seeing eye in a phase 1 clinical trial received a second subretinal injection in their contralateral eye in a follow-on clinical trial...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28228182/cost-effectiveness-of-computerized-cognitive-behavioural-therapy-for-the-treatment-of-depression-in-primary-care-findings-from-the-randomised-evaluation-of-the-effectiveness-and-acceptability-of-computerised-therapy-reeact-trial
#12
A Duarte, S Walker, E Littlewood, S Brabyn, C Hewitt, S Gilbody, S Palmer
BACKGROUND: Computerized cognitive-behavioural therapy (cCBT) forms a core component of stepped psychological care for depression. Existing evidence for cCBT has been informed by developer-led trials. This is the first study based on a large independent pragmatic trial to assess the cost-effectiveness of cCBT as an adjunct to usual general practitioner (GP) care compared with usual GP care alone and to establish the differential cost-effectiveness of a free-to-use cCBT programme (MoodGYM) in comparison with a commercial programme (Beating the Blues) in primary care...
February 23, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28222021/intense-blue-light-therapy-during-the-night-time-does-not-suppress-the-rhythmic-melatonin-biosynthesis-in-a-young-boy
#13
K Stebelova, J Kosnacova, M Zeman
OBJECTIVE: Melatonin is a hormone predominantly synthesized and secreted during the night by the pineal gland. Artificial light at night, especially its blue part, acutely suppresses the melatonin production. Th e aim of the present study was to find out, whether an intense blue light phototherapy of severe hyperbilirubinemia, may suppress the melatonin production during the night when the eyes will be properly protected by a sleep mask. METHODS: The main melatonin metabolite, 6-sulphatoxymelatonin was measured in urine in a nine-year old boy suffering from the Crigler-Najjar syndrome type I...
January 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28199748/daylight-photodynamic-therapy-with-methylene-blue-in-plane-warts-a-randomized-double-blind-placebo-controlled-study
#14
G Fathy, M K Asaad, H M Rashid
Photodynamic therapy (PDT) is a technique that utilizes reactive oxygen species produced by a non-toxic dye or photosensitizer molecule in the presence of low intensity visible light to kill mammalian or microbial cells ((1)) . The advantages of PDT are numerous, it is a safe, non-invasive technique which yields effective therapeutic results ((2)) . Photodynamic therapy is not free of adverse effects. The most common one is pain during illumination. With the use of portable light sources to optimize the procedure and facilitate outpatient treatment, the concept of ambulatory PDT has emerged...
February 15, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28187758/photodynamic-therapy-combined-to-cisplatin-potentiates-cell-death-responses-of-cervical-cancer-cells
#15
Laura Marise de Freitas, Rodolfo Bortolozo Serafim, Juliana Ferreira de Sousa, Thaís Fernanda Moreira, Cláudia Tavares Dos Santos, Amanda Martins Baviera, Valeria Valente, Christiane Pienna Soares, Carla Raquel Fontana
BACKGROUND: Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxic photosensitizing agent to the patient with subsequent localized exposure to a light source of a specific wavelength, resulting in a cytotoxic response to oxidative damage. The present study intended to evaluate in vitro the type of induced death and the genotoxic and mutagenic effects of PDT alone and associated with cisplatin...
February 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28184200/a-dynamic-model-for-prediction-of-psoriasis-management-by-blue-light-irradiation
#16
Zandra C Félix Garza, Joerg Liebmann, Matthias Born, Peter A J Hilbers, Natal A W van Riel
Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irradiation scheme regime of blue light-based therapy for psoriasis. We investigated the underlying mechanism of blue light irradiation of psoriatic skin, and tested the hypothesis that regulation of proliferation is a key process...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28167827/utilizing-the-power-of-cerenkov-light-with-nanotechnology
#17
REVIEW
Travis M Shaffer, Edwin C Pratt, Jan Grimm
The characteristic blue glow of Cerenkov luminescence (CL) arises from the interaction between a charged particle travelling faster than the phase velocity of light and a dielectric medium, such as water or tissue. As CL emanates from a variety of sources, such as cosmic events, particle accelerators, nuclear reactors and clinical radionuclides, it has been used in applications such as particle detection, dosimetry, and medical imaging and therapy. The combination of CL and nanoparticles for biomedicine has improved diagnosis and therapy, especially in oncological research...
February 7, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28129422/antimicrobial-blue-light-therapy-for-infectious-keratitis-ex-vivo-and-in-vivo-studies
#18
Hong Zhu, Irene E Kochevar, Irmgard Behlau, Jie Zhao, Fenghua Wang, Yucheng Wang, Xiaodong Sun, Michael R Hamblin, Tianhong Dai
Purpose: To investigate the effectiveness of antimicrobial blue light (aBL) as an alternative or adjunctive therapeutic for infectious keratitis. Methods: We developed an ex vivo rabbit model and an in vivo mouse model of infectious keratitis. A bioluminescent strain of Pseudomonas aeruginosa was used as the causative pathogen, allowing noninvasive monitoring of the extent of infection in real time via bioluminescence imaging. Quantitation of bacterial luminescence was correlated to colony-forming units (CFU)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28121497/effect-of-photodynamic-antimicrobial-chemotherapy-on-mono-and-multi-species-cariogenic-biofilms-a-literature-review
#19
Maria Tayara Marques de Freitas, Talyta Teixeira Soares, Maria Gerusa Brito Aragão, Ramille Araújo Lima, Simone Duarte, Iriana Carla Junqueira Zanin
OBJECTIVE: The aim of this literature review is to study the effect of photodynamic antimicrobial chemotherapy (PACT) on mono and multi-species cariogenic biofilms. METHODS: To this purpose, the database, PubMed, was searched using the descriptors, photodynamic therapy, antimicrobial photodynamic chemotherapy, and photoinactivation, associated with the mandatory presence of the word biofilm. A total of 98 references published from 2003 to 2016 were selected. Moreover, literature reviews (15), investigations that did not have biofilms related to dental caries (65), and those that did not have Streptococcus mutans count as an outcome (7) were excluded, yielding a final amount of 11 publications...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28099873/antimicrobial-photodynamic-therapy-as-an-adjunct-for-treatment-of-deep-carious-lesions-a-systematic-review
#20
REVIEW
Fabian Cieplik, Wolfgang Buchalla, Elmar Hellwig, Ali Al-Ahmad, Karl-Anton Hiller, Tim Maisch, Lamprini Karygianni
For deep carious lesions, a more conservative treatment modality ("selective caries removal") has been proposed, where only the heavily contaminated dentine is removed. In this regard, effective adjuncts for cavity disinfection such as the antimicrobial photodynamic therapy (aPDT) can be valuable clinically prior to definitive restoration. Therefore, the aim of this study was to systematically assess clinical studies on the effectiveness of aPDT as a supplementary tool in the treatment of deep caries lesions...
January 15, 2017: Photodiagnosis and Photodynamic Therapy
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