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https://www.readbyqxmd.com/read/27904491/intravenous-transplantation-of-mouse-embryonic-stem-cells-attenuates-demyelination-in-an-icr-outbred-mouse-model-of-demyelinating-diseases
#1
Kidsadagon Pringproa, Anucha Sathanawongs, Chananthida Khamphilai, Sarocha Sukkarinprom, Apichart Oranratnachai
Induction of demyelination in the central nervous system (CNS) of experimental mice using cuprizone is widely used as an animal model for studying the pathogenesis and treatment of demyelination. However, different mouse strains used result in different pathological outcomes. Moreover, because current medicinal treatments are not always effective in multiple sclerosis patients, so the study of exogenous cell transplantation in an animal model is of great importance. The aims of the present study were to establish an alternative ICR outbred mouse model for studying demyelination and to evaluate the effects of intravenous cell transplantation in the present developed mouse model...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27867727/optical-lens-microneedle-array-for-percutaneous-light-delivery
#2
Moonseok Kim, Jeesoo An, Ki Su Kim, Myunghwan Choi, Matjaž Humar, Sheldon J J Kwok, Tianhong Dai, Seok Hyun Yun
The limited penetration depth of light in skin tissues is a practical bottleneck in dermatologic applications of light-induced therapies, including anti-microbial blue light therapy and photodynamic skin cancer therapy. Here, we demonstrate a novel device, termed optical microneedle array (OMNA), for percutaneous light delivery. A prototype device with a 11 by 11 array of needles at a spacing of 1 mm and a length of 1.6 mm was fabricated by press-molding poly-(lactic acid) (PLA) polymers. The device also incorporates a matched microlens array that focuses the light through the needle tips at specific points to achieve an optimal intensity profile in the tissue...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27851015/1379-blue-light-therapy-modulates-the-systemic-response-to-sepsis-in-mice-and-humans
#3
Anthony Lewis, Du Yuan, Xianghong Zhang, Richard Collage, Paul Waltz, Brian Zuckerbraun, Derek Angus, Matthew Rosengart
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27835685/light-tnfsf14-increases-the-survival-and-proliferation-of-human-bone-marrow-derived-mesenchymal-stem-cells
#4
Sook-Kyoung Heo, Eui-Kyu Noh, Gi-Dong Gwon, Jeong Yi Kim, Jae-Cheol Jo, Yunsuk Choi, SuJin Koh, Jin Ho Baek, Young Joo Min, Hawk Kim
LIGHT (HVEM-L, TNFSF14, or CD258), an entity homologous to lymphotoxins, with inducible nature and the ability to compete with herpes simplex virus glycoprotein D for herpes virus entry mediator (HVEM)/tumor necrosis factor (TNF)-related 2, is a member of the TNF superfamily. It is expressed as a homotrimer on activated T cells and dendritic cells (DCs), and has three receptors: HVEM, LT-β receptor (LTβR), and decoy receptor 3 (DcR3). So far, three receptors with distinct cellular expression patterns are known to interact with LIGHT...
2016: PloS One
https://www.readbyqxmd.com/read/27827890/in-vitro-photodynamic-effect-of-phycocyanin-against-breast-cancer-cells
#5
Subramaniyan Bharathiraja, Hansu Seo, Panchanathan Manivasagan, Madhappan Santha Moorthy, Suhyun Park, Jungwan Oh
C-phycocyanin, a natural blue-colored pigment-protein complex was explored as a novel photosensitizer for use in low-level laser therapy under 625-nm laser illumination. C-phycocyanin produced singlet oxygen radicals and the level of reactive oxygen species (ROS) were raised in extended time of treatment. It did not exhibit any visible toxic effect in the absence of light. Under 625-nm laser irradiation, c-phycocyanin generated cytotoxic stress through ROS induction, which killed MDA-MB-231 breast cancer cells depending on concentrations...
November 3, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27810128/novel-folic-acid-conjugated-fe3o4-zno-hybrid-nanoparticles-for-targeted-photodynamic-therapy
#6
Kunal Patel, Behin Sundara Raj, Yan Chen, Xia Lou
A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produced nano-PSs, due to the charge recombination via electron trapping by dissolved Fe(3+). A time and dose dependant toxicity associated with the nano-PSs was observed upon exposure to human epithelial colorectal adenocarcinoma (Caco-2) cells in the dark...
October 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27809305/chronic-activation-of-the-d156a-point-mutant-of-channelrhodopsin-2-signals-apoptotic-cell-death-the-good-and-the-bad
#7
Michael Perny, Lukas Muri, Heather Dawson, Sonja Kleinlogel
Channelrhodopsin-2 (ChR2) has become a celebrated research tool and is considered a promising potential therapeutic for neurological disorders. While making its way into the clinic, concerns about the safety of chronic ChR2 activation have emerged; in particular as the high-intensity blue light illumination needed for ChR2 activation may be phototoxic. Here we set out to quantify for the first time the cytotoxic effects of chronic ChR2 activation. We studied the safety of prolonged illumination on ChR2(D156A)-expressing human melanoma cells as cancer cells are notorious for their resistance to killing...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27777143/the-influence-of-photodynamic-therapy-with-5-aminolevulinic-acid-on-senescent-skin-cancer-cells
#8
Mantas Grigalavicius, Marina Juraleviciute, Mateusz Kwitniewski, A Juzeniene
BACKGROUND: Senescent cells, which are resistant to apoptosis, accumulate with age and after ultraviolet (UV) radiation, chemotherapy and radiation therapy. Preventing or eliminating senescent cells may be crucial for protection against skin cancer development and improving tumour treatment. The aim of the present study was to investigate the potential of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) to induce senescence in skin cancer cells and to eliminate senescent cells induced by chemotherapy (bleomycin) or UVA (315-400nm) exposure...
October 21, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27762647/clinical-comparison-of-salicylic-acid-peel-and-led-laser-phototherapy-for-the-treatment-of-acne-vulgaris-in-teenagers
#9
Monique Narciso Alba, Marli Gerenutti, Valquíria Miwa Hanai Yoshida, Denise Grotto
Acne vulgaris treatments usually cause sensitivity, teratogenicity and bacterial resistance. Investigations of other therapeutic techniques, such as phototherapy, are highly relevant. Thus, we compared the effectiveness of two Acne vulgaris treatments in adolescents: peeling with salicylic acid (SA) and phototherapy. Teens were randomly divided into: group I, treatment with SA peels (10%) and group II, treatment with phototherapy (blue LED and red laser lights). Photographs were taken before and after ten sessions of each treatment, carried out weekly, and compared...
November 23, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27753430/light-activated-antimicrobial-agents-can-inactivate-oral-malodour-causing-bacteria
#10
Marika Rai, David Spratt, Paola R Gomez-Pereira, Jay Patel, Sean P Nair
Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current chemical treatments for oral malodour such as mouthwashes containing chlorhexidine or essential oils, are not sufficiently effective at reducing the bacterial load on the tongue. One potential alternative to current chemical treatments for oral malodour is the use of light activated antimicrobial agents (LAAAs), which display no toxicity or antimicrobial activity in the dark, but when exposed to light of a specific wavelength produce reactive oxygen species which induce damage to target cells in a process known as photodynamic inactivation...
October 18, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27745720/-can-we-do-therapy-without-a-therapist-active-components-of-computer-based-cbt-for-depression
#11
G Iakimova, S Dimitrova, T Burté
OBJECTIVES: Computer-delivered Cognitive Behavioral Therapies (C-CBT) are emerging as therapeutic techniques which contribute to overcome the barriers of health care access in adult populations with depression. The C-CBTs provide CBT techniques in a highly structured format comprising a number of educational lessons, homework, multimedia illustrations and supplementary materials via interactive computer interfaces. Programs are often administrated with a minimal or regular support provided by a clinician or a technician via email, telephone, online forums, or during face-to-face consultations...
October 10, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27711590/ph-responsive-drug-release-and-nir-triggered-singlet-oxygen-generation-based-on-a-multifunctional-core-shell-shell-structure
#12
Renlu Han, Haopeng Yi, Junhui Shi, Zongjun Liu, Hao Wang, Yafei Hou, You Wang
A multifunctional platform with pH-responsive drug release and near-infrared (NIR) light-triggered photodynamic therapy (PDT) was designed and prepared using the novel core-shell-shell structure. The multifunctional platform consists of an upconversion nanoparticle (UCNP) emission core, a photosensitizer methylene blue (MB) embedded dense silica sandwich shell, and a polyethyleneimine conjugated folic acid (PEI-FA) gated mesoporous silica (MS) outmost shell with doxorubicin hydrochloride (DOX) loaded inside...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27670126/light-therapies-for-acne
#13
Jelena Barbaric, Rachel Abbott, Pawel Posadzki, Mate Car, Laura H Gunn, Alison M Layton, Azeem Majeed, Josip Car
BACKGROUND: Acne vulgaris is a very common skin problem that presents with blackheads, whiteheads, and inflamed spots. It frequently results in physical scarring and may cause psychological distress. The use of oral and topical treatments can be limited in some people due to ineffectiveness, inconvenience, poor tolerability or side-effects. Some studies have suggested promising results for light therapies. OBJECTIVES: To explore the effects of light treatment of different wavelengths for acne...
September 27, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27667449/near-infrared-light-mediated-photodynamic-therapy-nanoplatform-by-the-electrostatic-assembly-of-upconversion-nanoparticles-with-graphitic-carbon-nitride-quantum-dots
#14
Ming-Hsien Chan, Chieh-Wei Chen, I-Jung Lee, Yung-Chieh Chan, Datao Tu, Michael Hsiao, Chung-Hsuan Chen, Xueyuan Chen, Ru-Shi Liu
Photodynamic therapy (PDT) is a promising antitumor treatment that is based on photosensitizers. This therapy kills cancer cells by generating reactive oxygen species (ROS) after irradiation with specific laser wavelengths. Being a potential photosensitizer, graphitic carbon nitride (g-C3N4) quantum dots (QDs) are noncytotoxic. Although the use of g-C3N4 QDs is challenged by the limited tissue penetration of UV light, g-C3N4 QDs display excellent ultraviolet (UV) light-triggered cytotoxicity. The g-C3N4 QDs were synthesized using a solid-phase hydrothermal method...
October 17, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27662784/mechanisms-of-phosphene-generation-in-ocular-proton-therapy-as-related-to-space-radiation-exposure
#15
D Chuard, V Anthonipillai, R Dendale, C Nauraye, E Khan, C Mabit, L De Marzi, L Narici
Particle therapy provides an opportunity to study the human response to space radiation in ground-based facilities. On this basis, a study of light flashes analogous to astronauts' phosphenes reported by patients undergoing ocular proton therapy has been undertaken. The influence of treatment parameters on phosphene generation was investigated for 430 patients treated for a choroidal melanoma at the proton therapy centre of the Institut Curie (ICPO) in Orsay, France, between 2008 and 2011. 60% of them report light flashes, which are predominantly (74%) blue...
August 2016: Life Sciences in Space Research
https://www.readbyqxmd.com/read/27650508/photobiomodulation-blue-and-green-light-encourages-osteoblastic-differentiation-of-human-adipose-derived-stem-cells-role-of-intracellular-calcium-and-light-gated-ion-channels
#16
Yuguang Wang, Ying-Ying Huang, Yong Wang, Peijun Lyu, Michael R Hamblin
UNLABELLED: Human adipose-derived stem cells (hASCs) have the potential to differentiate into several different cell types including osteoblasts. Photobiomodulation (PBM) or low level laser therapy (LLLT) using red or near-infrared wavelengths has been reported to have effects on both proliferation and osteogenic differentiation of stem cells. We examined the effects of delivering four different wavelengths (420 nm, 540 nm, 660 nm, 810 nm) at the same dose (3 J/cm(2)) five times (every two days) on hASCs cultured in osteogenic medium over three weeks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27641507/papain-gel-containing-methylene-blue-for-simultaneous-caries-removal-and-antimicrobial-photoinactivation-against-streptococcus-mutans-biofilms
#17
Zenildo Santos Silva, Ying-Ying Huang, Lucas Freitas de Freitas, Cristiane Miranda França, Sergio Brossi Botta, Patrícia Aparecida Ana, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes, Alessandro Deana, Cintia Raquel Lima Leal, Renato Araujo Prates, Michael R Hamblin, Sandra Kalil Bussadori
This study intended to evaluate the effects of a papain-gel with a red-light absorbing pigment (methylene blue - MB) to mediate photodynamic therapy (PDT) against Streptococcus mutans biofilms. The PapaMBlue was compared with free MB to generate reactive oxygen species using fluorescence probes (SOSG and HPF). PDT (660-nm light) was carried out against S. mutans biofilms grown on either plastic dishes or on collagen membrane and assayed by CFU, live-dead staining using confocal microscopy, transmission electron microscopy and H&E staining for collagen films...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27636556/dual-wavelength-stimulation-of-polymeric-nanoparticles-for-photothermal-therapy
#18
Sneha S Kelkar, Eleanor McCabe-Lankford, Richard Albright, Phil Harrington, Nicole H Levi-Polyachenko
BACKGROUND AND OBJECTIVE: Photothermal therapy (PTT) has several applications in the areas of wound healing, pain management, bacterial infection control, and cancer treatment dependent on the temperature that is generated. PTT is often used exclusively with near infrared (NIR) light and most nanoparticles (NP) used for PTT are designed to absorb within one narrow range of wavelengths. We have developed a dual-wavelength photothermal therapy by capitalizing on the dual absorption of nanoparticles in the blue and NIR range...
September 16, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27622260/fingernail-photo-onycholysis-after-aminolevulinic-acid-photodynamic-therapy-under-blue-light-for-treatment-of-actinic-keratoses-on-the-face
#19
Karina Paci, Rebecca Todd Bell, Beth Goldstein
No abstract text is available yet for this article.
August 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27617768/comparison-of-the-efficiency-of-rose-bengal-and-methylene-blue-as-photosensitizers-in-photodynamic-therapy-techniques-for-enterococcus-faecalis-inactivation
#20
Catia Cilene Nass Sebrão, Arandi Ginane Bezerra Junior, Paulo Henrique Condeixa de França, Leslie Ecker Ferreira, Vania Portela Ditzel Westphalen
The aim of this in vitro study was to compare the efficiency of a photodynamic therapy (PDT) technique employing rose bengal (RB) and methylene blue (MB) as photosensitizers (PSs) to reduce the viability of Enterococcus faecalis, a well-known pathogen found in root canal systems. Currently, in several clinical applications, including in the field of endodontics, MB is employed in association with a red laser source for the photoinactivation of pathogenic bacteria. Here, it was used at 0.01% (31.2 mol/L) in association with a red (660 nm) laser as the excitation source in the MB group (MBG)...
September 9, 2016: Photomedicine and Laser Surgery
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