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Blue light therapy

Darika Saitawee, Aroon Teerakapong, Noppawan Phumala Morales, Paiboon Jitprasertwong, Doosadee Hormdee
BACKGROUND AND OBJECTIVE: Curcumin, one of an established curcuminoid substances extracted from Curcuma longa, has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Curcuminoid substances has been reported to have benefits in treating dental chronic infection and inflammation diseases, such as chronic periodontitis. The purpose of this study was to find the optimum concentration of Curcuma longa (CL) extract, containing all curcuminoid substances, and the power density of blue light (BL) in photodynamic therapy against periodontally pathogenic bacteria, A...
March 10, 2018: Photodiagnosis and Photodynamic Therapy
Ardeshir Rineh, John B Bremner, Michael R Hamblin, Anthony R Ball, George P Tegos, Michael J Kelso
Resistance of bacteria to antibiotics is a public health concern worldwide due to the increasing failure of standard antibiotic therapies. Antimicrobial photodynamic inactivation (aPDI) is a promising non-antibiotic alternative for treating localized bacterial infections that uses non-toxic photosensitizers and harmless visible light to produce reactive oxygen species and kill microbes. Phenothiazinium photosensitizers like methylene blue (MB) and toluidine blue O are hydrophobic cations that are naturally expelled from bacterial cells by multidrug efflux pumps, which reduces their effectiveness...
February 24, 2018: Bioorganic & Medicinal Chemistry Letters
Toshihiro Kushibiki, Miya Ishihara
The optogenetics approach uses a combination of genetic and optical methods to initiate and control functions in specific cells of biological tissues. Since the high-speed control of neuronal activity by irradiating channelrhodopsin-2 with blue light was reported in 2005, tremendous advancement and application of optogenetics in the field of neuroscience, such as in studies that associate neuronal activity with behaviors, have been initiated. Optogenetics is not only used as a research tool, but is also started to apply in the diagnosis of a disease or as therapy in various studies...
March 2, 2018: Current Gene Therapy
Larissa S Amaral, Eduardo B Azevedo, Janice R Perussi
Antimicrobial Photodynamic Inactivation (a-PDI) is based on the oxidative destruction of biological molecules by reactive oxygen species generated by the photo-excitation of a photosensitive molecule. When the a-PDT is performed along with the use of mathematical models, the optimal conditions for maximum inactivation are easily found. Experimental designs allow a multivariate analysis of the experimental parameters. This is usually made using a univariate approach, which demands a large number of experiments, being time and money consuming...
February 27, 2018: Photodiagnosis and Photodynamic Therapy
Jing Zuo, Langping Tu, Qiqing Li, Yansong Feng, Ivo Que, Youlin Zhang, Xiaomin Liu, Bin Xue, Luis J Cruz, Yulei Chang, Hong Zhang, Xianggui Kong
Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts -photobleaching. However, current PUCNPs follow solely Yb3+ /Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV-blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs-NaErF4 @NaYF4 @NaYbF4 :0...
March 2, 2018: ACS Nano
Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shimon Otake, Shogo Tamura, Jiro Ichikawa, Makoto Osada, Kaneo Satoh, Yukio Ozaki, Katsue Suzuki-Inoue
BACKGROUND: Rhodocytin, a disulfide-linked heterodimeric C-type lectin consisting of α- and β-subunits from Calloselasma rhodostoma, induces platelet aggregation through C-type lectin-like receptor 2 (CLEC-2). CLEC-2 is a physiological binding partner of podoplanin (PDPN) expressed on some tumor cell types and is involved in tumor cell-induced platelet aggregation and tumor metastasis. Thus, modified rhodocytin may be a possible source for anti-CLEC-2 medicine in both anti-platelet and anti-metastasis therapy...
February 28, 2018: Journal of Thrombosis and Haemostasis: JTH
A S Lapchenko, A G Kucherov, R Ya Order, A A Lapchenko
The objective of the present study was the enhancement of the effectiveness of the treatment of the consequences of the gunshot wounds and mine-blast injuries inflicted to the face, head, and neck encountered in the otolaryngological practice as well as the prevention of the formation of the large demarcation areas in the injured tissues and the preparation of these tissues for the further restorative treatment. Anti-microbial and anti-inflammatory photodynamic therapy (PDT) as well as light-emitting-diode (LED) phototherapy were carried out in 20 patients who suffered gunshot wounds and mine-blast injuries to the face, head, and neck...
2018: Vestnik Otorinolaringologii
Ming-Yeh Yang, Kai-Chih Chang, Liang-Yu Chen, Po-Ching Wang, Chih-Chiang Chou, Zhong-Bin Wu, Anren Hu
Photodynamic inactivation (PDI) is a non-invasive and safe therapeutic method for microbial infections. Bacterial antibiotic resistance is caused by antibiotics abuse. Drug-resistant Acinetobacter spp. is a serious problem in hospitals around the world. These pathogens from nosocomial infections have high mortality rates in frailer people, and Acinetobacter spp. is commonly found in immunocompromised patients. Visible light is safer than ultraviolet light (UV) for PDI of nosocomial pathogens with mammalian cells...
February 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
Edward V Maytin, Urvashi Kaw, Muneeb Ilyas, Judith A Mack, Bo Hu
BACKGROUND: Photodynamic therapy (PDT) is a non-scarring alternative for treating basal cell carcinoma (BCC) in patients with Basal Cell Nevus Syndrome (BCNS), also known as Gorlin syndrome. In Europe, red light (635 nm) is the predominant source for PDT, whereas in the United States blue light (400 nm) is more widely available. The objective of this study was to conduct a head-to-head comparison of blue light and red light PDT in the same BCNS patients. METHODS: In a pilot study of three patients with 141 BCC lesions, 5-aminolevulinate (20% solution) was applied to all tumors...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
Yann Molard, Malo Robin, Noée Dumait, Maria Amela-Cortes, Claire Roiland, Maxime Harnois, Emmanuel Jacques, Hervé Folliot
Hybrid nanomaterials made of inorganic nanocomponents dispersed in an organic host raise an increasing interest as low-cost solution-processable functional materials. However, preventing phase segregation while allowing a high inorganic doping content remains a major challenge, and usual methods require a functionalization step prior integration. Herein, we report a new approach to design such nanocomposite in which lead-free and cadmium-free ceramic-like metallic nanocluster compounds are embedded at 10 wt % in organic copolymers, without any functionalization...
February 22, 2018: Chemistry: a European Journal
Maria Lucia Frade, Sarah Raquel de Annunzio, Giovana Maria Fioramonti Calixto, Francesca Damiani Victorelli, Marlus Chorilli, Carla Raquel Fontana
Chitosan (CH) is a biopolymer that exhibits a number of interesting properties such as anti-inflammatory and antibacterial activity and is also a promising platform for the incorporation of photosensitizing agents. This study aimed to evaluate the efficacy of antimicrobial activity of chitosan hydrogel formulation alone and in combination with the methylene blue (MB) associated with antimicrobial photodynamic therapy (aPDT) against planktonic and biofilm phase of Propionibacterium acnes . Suspensions were sensitized with 12...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Peter J Gwynne, Maurice P Gallagher
Antimicrobial resistance is a significant and growing concern. To continue to treat even simple infections, there is a pressing need for new alternative and complementary approaches to antimicrobial therapy. One possible addition to the current range of treatments is the use of narrow-wavelength light as an antimicrobial, which has been shown to eliminate a range of common pathogens. Much progress has already been made with blue light but the potential of other regions of the electromagnetic spectrum is largely unexplored...
2018: Frontiers in Microbiology
Michael R Hamblin
Photodynamic therapy (PDT) involves the combination of non-toxic dyes called photosensitizers (PS) and harmless visible light that interact with ambient oxygen to give reactive oxygen species (ROS) that can damage biomolecules and kill cells. PDT has mostly been developed as a cancer therapy but can also be used as an antimicrobial approach against localized infections. However even the longest wavelength used for exciting PS (in the 700 nm region) has relatively poor tissue penetration, and many PS are much better excited by blue and green light...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Thaisa Helena Silva Fonseca, Marina Alacoque, Fabrício Marcus Silva Oliveira, Betânia Maria Soares, Henrique Vitor Leite, Marcelo Vidigal Caliari, Maria Aparecida Gomes, Haendel Busatti
The emergence of nitroimidazole resistant isolates has been an aggravating factor in the treatment of trichomoniasis, the most common non-viral sexually transmitted disease in the world. This particularity highlights the importance of new technologies that are safe, effective, and have minor side effects or resistance. Hence, we evaluated the effectiveness of photodynamic therapy on the inactivation of Trichomonas vaginalis in vitro. We used methylene blue as a photosensitizing substance, and a light-emitting diode (LED) for irradiation of metronidazole sensitive and resistant strains...
February 11, 2018: Photodiagnosis and Photodynamic Therapy
Min-Chao Liu, Bing Liu, Xiang-Yu Sun, Hui-Chao Lin, Jia-Zheng Lu, Shu-Fang Jin, Si-Qi Yan, Yan-Yu Li, Ping Zhao
The dose-dependent toxicity and low specificity against cancerous cells have restricted the clinical use of daunomycin (DNM). Titanium dioxide (TiO2) has been wildly used as an inorganic photodynamic therapy (PDT) agent and drug carrier. To facilitate the targeted drug delivery and combined therapy, in the present study, TiO2-coated Fe3O4 nanoparticles (Fe3O4@TiO2 NPs) were employed to load DNM and the drug-loaded Fe3O4@TiO2-DNM Nps exhibited smart pH-controlled releasing and satisfactory cytotoxicity as well as photocytotocity...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Kazuhide Shimizu, Masayuki Nitta, Takashi Komori, Takashi Maruyama, Takayuki Yasuda, Yu Fujii, Ken Masamune, Takakazu Kawamata, Taketoshi Maehara, Yoshihiro Muragaki
Objective: The goal of this study was to demonstrate the feasibility of intraoperative photodynamic diagnosis (PDD) of malignant glioma using the fluorescence from talaporfin sodium (TS), which is used simultaneously for photodynamic therapy (PDT). Methods: Patients with suspected primary malignant glioma who were eligible for surgical removal of the tumor and PDT with TS were enrolled in this prospective study. Tissue samples were obtained from the contrast-enhanced (CE) region and from the surrounding non-contrast-enhanced (NCE) marginal tissue at the boundary between the tumor and normal tissue...
2018: Frontiers in Neurology
Domenico Piccolo, Dimitra Kostaki
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC)...
February 7, 2018: Biomedicines
Ali Bagheri, Zheye Li, Cyrille Boyer, May Lim
The increased applications of lanthanide-doped upconversion nanoparticles (UCNPs) in areas such as biomedical imaging and therapy have raised the demand for high quality nanocrystals with strong and controllable luminescence intensity. Whilst several different approaches including core/shell arrangement, dye sensitization and plasmonic metallic nanostructures have been employed to improve the upconversion luminescence of UCNPs, they may be impractical for scale-up production and applications. Herein, a mathematical model that was developed using multivariate statistical analysis shows that the key to optimising the NIR and blue light emission of NaY1-(x+y)YbxF4:Tmy UCNPs is dopant balancing, where the composition of both ytterbium (Yb3+) sensitizer and thulium (Tm3+) activator is controlled in a way that the concentration and proximity of the dopants to each other can reduce cross-relaxation between Tm3+ and self-quenching that is due to sub-optimal Yb3+ concentrations, and consequently, favours efficient energy transfer between the Yb3+ sensitizers and Tm3+ activators...
February 7, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Bleron Azizi, Ana Budimir, Ivona Bago, Blerim Mehmeti, Suzana Jakovljević, Jeta Kelmendi, Aleksandra Presecki Stanko, Dragana Gabrić
BACKGROUND: We aimed to evaluate the antimicrobial efficacy of photodynamic therapy (PDT) and light-activated disinfection (LAD) on zirconia dental implants contaminated with three bacterial species and investigate if the PDT and LAD cause implant surface alterations. METHODS: Seventy-two zirconia dental implants were contaminated with a bacterial suspension of Prevotella intermedia, Actinomyces actinomycetemcomitans, and Porphyromonas gingivalis. The implants were subsequently randomly divided into four groups (n = 12 dental implants/each) according to the decontamination protocol: Group 1 (PDT1) - PDT (660 nm, 100 mW) with toluidine blue; Group 2 (PDT2) - PDT (660 nm, 100 mW) with phenothiazine chloride dye; Group 3 (LAD) - light emitting diode (LED) with toluidine blue; and Group 4 (TB) - toluidine blue without the application of light...
February 1, 2018: Photodiagnosis and Photodynamic Therapy
Nhat Quang Bui, Soon-Woo Cho, Madhappan Santha Moorthy, Sang Min Park, Zhonglie Piao, Seung Yun Nam, Hyun Wook Kang, Chang-Seok Kim, Junghwan Oh
Photoacoustic imaging (PAI) is a noninvasive imaging tool to visualize optical absorbing contrast agents. Due to high ultrasonic resolution and superior optical sensitivity, PAI can be used to monitor nanoparticle-mediated cancer therapy. The current study synthesized Food and Drug Administration-approved Prussian blue (PB) in the form of nanoparticles (NPs) with the peak absorption at 712 nm for photoacoustically imaging tumor-bearing mouse models. To monitor PB NPs from the background tissue in vivo, we also developed a new 700-nm-region stimulated Raman scattering (SRS) source (pulse energy up to 200 nJ and repetition rate up to 50 kHz) and implemented optical-resolution photoacoustic microscopy (OR-PAM)...
January 31, 2018: Scientific Reports
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