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https://www.readbyqxmd.com/read/29139000/effect-of-light-polarization-on-the-efficiency-of-photodynamic-therapy-of-basal-cell-carcinomas-an-in-vitro-cellular-study
#1
M JalalKamali, S N Nematollahi-Mahani, M Shojaei, A Shamsoddini, N Arabpour
In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to green (532 pm 20 nm) irradiation from light emitting diodes. Cell survival was measured by the colorimetric assay (WST-1) and Trypan blue staining. The colorimetric assay showed a pronounced decrease in the cell viability (up to 30%) using polarized light compared to the non-polarized one in the wavelength region used...
November 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29131564/light-emitting-photon-upconversion-nanoparticles-in-the-generation-of-transdermal-reactive-oxygen-species
#2
Martin Prieto, Alina Rwei, Teresa Alejo, Wei Tuo, Maria Teresa Lopez-Franco, Gracia Mendoza, Victor Sebastian, Daniel S Kohane, Manuel Arruebo
Common photosensitizers used in photodynamic therapy do not penetrate the skin effectively. In addition, the visible blue and red lights used to excite such photosensitizers have shallow penetration depths through tissue. To overcome these limitations, we have synthesized ultraviolet and visible light emitting, energy-transfer based upconversion nanoparticles, and co-encapsulated them inside PLGA-PEG nanoparticles with photosensitizer protoporphyrin IX. Nd3+ has been introduced as sensitizer in the upconversion nanostructures to allow their excitation at 808 nm...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29126958/effects-of-led-based-photodynamic-therapy-using-red-and-blue-lights-with-natural-hydrophobic-photosensitizers-on-human-glioma-cell-line
#3
Zahra Jamali, Sedigheh Marjaneh Hejazi, Seyed Mohsen Ebrahimi, Hemen Moradi-Sardareh, Maliheh Paknejad
Photodynamic therapy (PDT) has received high attention in cancer treatment due to its minimal side effects, specific cancer-targeting, non-invasion and low cost. It utilizes a specific group of anti-cancer drugs called photosensitizers (PS), which can be only activated under a certain wavelength light illumination and kills cancer cells. To screen the potential of PS and setup of PDT treatment protocol, it is essential to assess the PDT efficacy in vitro. In this study, a light-emitting diode- (LED-) based illumination system at two wavelengths (red & blue) with homogeneous and stable irradiation, and constant temperature conditions in 96-well plates was provided...
November 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29119936/recent-patents-on-light-based-anti-infective-approaches
#4
Imran Ahmed, Yanyan Fang, Min Lu, Quan Yan, Ahmed Mohamed Kamel El-Hussein, Michael R Hamblin, Tianhong Dai
BACKGROUND: Antibiotic resistance is one of the most serious health threats to modern medicine. The lack of potent antibiotics puts us at a disadvantage in the fight against infectious diseases, especially those caused by antibiotic-resistant microbial strains. To this end, an urgent need to search for alternative antimicrobial approaches has arisen. In the last decade, light-based therapy has made significant strides in this fight to combat antibiotic resistance among various microbial strains...
November 7, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29095531/low-level-red-led-light-inhibits-hyperkeratinization-and-inflammation-induced-by-unsaturated-fatty-acid-in-an-in-vitro-model-mimicking-acne
#5
Wen-Hwa Li, Ali Fassih, Curt Binner, Ramine Parsa, Michael D Southall
BACKGROUND AND OBJECTIVE: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm(2) have demonstrated marked effects on inflammatory acne lesions...
November 2, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29071031/the-effect-of-combination-of-red-infrared-and-blue-wavelengths-of-low-level-laser-on-reduction-of-abdominal-girth-a-before-after-case-series
#6
Katayoon Montazeri, Soheila Mokmeli, Maryam Barat
Introduction: The objective of this study was to assess the efficacy of a combination of 3 wavelengths (including red, infra-red, and blue) of low-level laser (LLL) as a non-invasive therapeutic method to reduce abdominal girth. To achieve biochemical activity on adipocytes, a red laser was used in our selective laser combination. Near-infrared laser was used to increase depth of penetration. Nitrosyl complexes of hemoglobin (NO-Hb) are sensitive to blue light, thereby leading to increase in release of biologically active nitric oxide (NO), which can affect tissue perfusion...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29064662/near-infrared-light-triggered-upconversion-optogenetic-nanosystem-for-cancer-therapy
#7
Bin Zheng, Hanjie Wang, Huizhuo Pan, Chao Liang, Wanying Ji, Li Zhao, Hongbin Chen, Xiaoqun Gong, Xiaoli Wu, Jin Chang
In vivo the application of optogenetic manipulation in deep tissue is seriously obstructed by the limited penetration depth of visible light that is continually applied to activate a photoactuator. Herein, we designed a versatile upconversion optogenetic nanosystem based on a blue-light-mediated heterodimerization module and rare-earth upconversion nanoparticles (UCNs). The UCNs worked as a nanotransducer to convert external deep-tissue-penetrating near-infrared (NIR) light to local blue light to noninvasively activate photoreceptors for optogenetic manipulation in vivo...
October 30, 2017: ACS Nano
https://www.readbyqxmd.com/read/29064222/ex-vivo-assessment-of-photodynamic-therapy-in-achieving-microbial-reduction
#8
Rodrigo Rodrigues Amaral, Eduardo Nunes, Maria Eugênia Alvarez-Leite, José Cláudio Faria Amorim, Martinho Campolina Rebello Horta, Maria Ilma de Sousa Cortês, Frank Ferreira Silveira, Stephen Cohen
The study was to assess the effects of photodynamic therapy (PDT) on root canals contaminated by Enterococcus faecalis (E. faecalis). PDT was performed with 0.005% methylene blue dye and with a low-intensity red emission laser. Microbiological samples were collected before, immediately and 72 hours after instrumentation. Although PDT performed with the chosen light parameters promoted additional microbial reduction, this therapy did not achieve a statistically significant reduction of E. faecalis.
March 2017: Journal of the California Dental Association
https://www.readbyqxmd.com/read/29063751/tannic-acid-fe-3-ag-nanofilm-exhibiting-superior-photodynamic-and-physical-antibacterial-activity
#9
Ziqiang Xu, Xiuhua Wang, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Jonathan Chiyuen Chung, Paul K Chu, Shuilin Wu
Silver nanoparticles (AgNPs) enwrapped in the biologically safe tannic acid (TA)/Fe(3+) nanofilm are synthesized by an ultrafast, green, simple, and universal method. The physical antibacterial activity and photodynamic antibacterial therapy (PAT) efficacy of the TA/Fe(3+)/AgNPs nanofilm were investigated for the first time, which exhibited a strong physical antibacterial activity as well as great biocompatibility, through in vitro and in vivo studies. The results disclosed that this hybrid coating could possess high PAT capabilities upon irradiation under a visible light of 660 nm, which is longer than those of previously reported green and blue sensitization light, thus allowing deeper light penetration into biological tissues...
November 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29061014/-enhancement-of-thermal-damage-to-epcam-positive-tumor-cells-by-novel-aptamer-guided-magnetic-nanoparticles
#10
L Y Zhang, M Wang, H B Wu, Y Yang, Q Li, H L Sun
Objective: To explore the thermal damage to epithelial cell adhesion molecule(EpCAM)-positive tumor cells by novel aptamer-guided magnetic nanoparticles(AptNPs). Methods: EpCAM aptamer SYL3C was connected to NPs via biotin-streptavidin reaction. The diameter of AptNPs were characterized by Dynamic Light Scattering(DLS). The binding feature of the aptamer to EpCAM-positive tumor cells was evaluated by Prussian blue dyeing. Thermal damage under alternative magnetic field was measured bylactate dehydrogenase (LDH)...
October 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29053537/thermal-ultra-short-photodynamic-therapy-heating-fibroblasts-during-sub-30-minute-incubation-of-5-aminolevulinic-acid-increases-photodynamic-therapy-induced-cell-death
#11
Eugene Koo, Evan Austin, Andrew Mamalis, Jared Jagdeo
BACKGROUND: Actinic keratoses (AKs) prevalence was estimated at 39.5 million Americans in 2004, and the cost to treat AKs that year was approximately 1 billion dollars. Photodynamic therapy (PDT) is an FDA-approved therapy for the treatment of AK. Recent studies have focused on reducing PDT treatment time while maintaining efficacy. OBJECTIVE: To investigate the use of thermal modulation to improve the efficacy of ultra short aminolevulinic acid (ALA) incubation PDT...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29045918/cervical-cancer-cells-hela-response-to-photodynamic-therapy-using-a-zinc-phthalocyanine-photosensitizer
#12
Natasha Hodgkinson, Cherie Ann Kruger, Mpho Mokwena, Heidi Abrahamse
Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hysterectomy. In locally advanced cancer the treatment of choice is concurrent chemo radiation. Although such treatment methods show promise, they do have adverse side effects. To minimize these effects, as well as prevent cancer re-occurrence, new treatment methods are being investigated. Photodynamic therapy (PDT) involves the selective uptake of a photosensitizer (PS) by cancer cells, illumination with light of an appropriate wavelength that triggers a photochemical reaction leading to the generation of reactive oxygen and subsequent tumor regression...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29045438/gold-nanorod-reshaping-in-vitro-and-in-vivo-using-a-continuous-wave-laser
#13
David Harris-Birtill, Mohan Singh, Yu Zhou, Anant Shah, Pakatip Ruenraroengsak, Maria Elena Gallina, George B Hanna, Anthony E G Cass, Alexandra E Porter, Jeffrey Bamber, Daniel S Elson
Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical absorption spectral peak wavelength is determined by their size and shape. Photothermal therapy using GNRs is typically established using near infrared light as this allows sufficient penetration into the tumour matrix. Continuous wave (CW) lasers are the most commonly applied source of near infrared irradiation on GNRs for tumour photothermal therapy...
2017: PloS One
https://www.readbyqxmd.com/read/29038666/study-of-methylene-blue-ototoxicity-in-the-guinea-pig
#14
Sarah Belhassen, Musaed Alzahrani, Marc-Elie Nader, Louis Gaboury, Issam Saliba
BACKGROUND: Methylene blue is widely used in the medical field, especially as a blue dye for staining. It is also used as a photosensitizing agent in antimicrobial photodynamic therapy, which once photoactivated is effective for the eradication of several multi-resistant bacteria. The objective of this study was to investigate the ototoxic potential of methylene blue and precise its use in otology. METHODS: It was a prospective animal study performed on guinea pigs in our tertiary medical center...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29031069/synthesis-and-biological-evaluation-of-a-platinum-ii-c-rgdyk-conjugate-for-integrin-targeted-photodynamic-therapy
#15
T Chatzisideri, S Thysiadis, S Katsamakas, P Dalezis, I Sigala, T Lazarides, E Nikolakaki, D Trafalis, O A Gederaas, M Lindgren, V Sarli
A cancer-targeting conjugate 4 of a cyclometalated [N,C,N-Pt(II)] complex bearing a NˆCˆN 1,3-di(2-pyridyl)-benzene with c(RGDyK) peptide as guiding molecule was designed and synthesized for real-time drug delivery monitoring in cancer cells and photodynamic therapy (PDT). This conjugate demonstrates a mild cytostatic effect to six cancer cell lines expressing integrins at different extent, while possessing promising features for PDT. Conjugate 4 demonstrated rapid cell uptake by receptor-mediated endocytosis and efficient generation of (1)O2 upon irradiation...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29024873/photodynamic-therapy-for-schistosoma-mansoni-promising-outcomes
#16
Nathália Bandeira de Melo, Letícia Fernanda Moreira Dos Santos, Mayara Santos de Castro, Raquel Lopes Martins Souza, Marcos José Marques, Aline Pereira Castro, Andreísa Teixeira de Castro, Marina Lara de Carli, João Adolfo Costa Hanemann, Matheus Siqueira Silva, Gabriel de Oliveira Isac Moraes, Luiz Alberto Beijo, Maísa Ribeiro Pereira Lima Brigagão, Felipe Fornias Sperandio
The purpose of this study was to assess, for the very first time, the effects of photodynamic therapy (PDT) on Schistosoma mansoni in vitro by measuring reactive oxygen species (ROS) generation throughout the treatment, as well as the behavior of the parasites (mating, motility and contraction/shortening), and damage to their tegument and excretory systems. The parasites were divided into 4 groups: control, photosensitizer, laser and PDT. Light irradiation was delivered with an InGaAlP low-level laser device operating at 660nm, with 40mW and 100J/cm(2)...
September 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29023192/a-study-on-the-macroscopic-morphometry-of-the-lesion-area-on-diabetic-ulcers-in-humans-treated-with-photodynamic-therapy-using-two-methods-of-measurement
#17
Patrícia Michelassi Carrinho, Dora Inés Kozusny Andreani, Vislaine de Aguiar Morete, Shizumi Iseri, Ricardo Scarparo Navarro, Antonio Balbin Villaverde
INTRODUCTION: Diabetes Mellitus is a chronic disease that can lead to lower-limb ulceration. The photodynamic therapy (PDT) is based on light interaction with a photosensitizer capable to promote bacterial death and acceleration of wound healing. This study aims to accomplish a macroscopic morphometry evaluation on diabetic ulcer area in humans that were under PDT. MATERIALS AND METHODS: A clinical study was conducted by convenience sample, experimental, controlled, and blinded, composed of 12 patients of both sexes with diabetic ulcers in lower limbs that were divided into two groups, control (n = 6) and PDT (n = 6)...
October 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29023186/photodynamic-therapy-associated-with-a-blue-dye-papain-based-gel-and-evaluation-of-its-degradation-of-type-i-collagen-fibers
#18
Sergio Brossi Botta, Patricia Aparecida Ana, Marcela Leticia Leal Gonçalves, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Renato de Araújo Prates, Aldo Brugnera Junior, Sandra Kalil Bussadori
OBJECTIVE: The aim of this in vitro study was to evaluate the degradation of type I collagen fibers after treatment with a papain-based gel associated with a blue dye (PapaMBlue™) for use in antimicrobial photodynamic therapy. MATERIALS AND METHODS: For such, 60 bioabsorbable membrane sponge discs were used. Group 1 was the negative control group. In groups 2, 3, and 4, the papain-based gel PapaMBlue gel was applied all over the samples for 4 min and irradiated using red laser (660 ± 10 nm) with 15, 30, and 40 J/cm(2), respectively...
October 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29022483/in-vitro-combined-effect-of-doxorubicin-and-sulfonated-zinc-phthalocyanine-mediated-photodynamic-therapy-on-mcf-7-breast-cancer-cells
#19
Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George, Heidi Abrahamse
Doxorubicin is a broad-spectrum antibiotic and anticancer drug used to treat a variety of human malignancies like breast cancer and leukaemia. Unfortunately, a dose-dependent side effect of this drug is common, representing a major obstacle to its use despite its therapeutic efficacy. Photodynamic therapy is an emerging non-invasive potential adjuvant for conventional cancer treatment. In an attempt to circumvent the dose-limiting effect of doxorubicin, this study aimed to investigate cellular anticancer activity of doxorubicin and sulfonated zinc phthalocyanine-mediated photodynamic therapy on MCF-7 cells alone and in combination...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28990789/singlet-oxygen-production-and-biological-activity-of-hexanuclear-chalcocyanide-rhenium-cluster-complexes-re6q8-cn-6-4-q-s-se-te
#20
Anastasiya O Solovieva, Kaplan Kirakci, Anton A Ivanov, Pavel Kubát, Tatiana N Pozmogova, Svetlana M Miroshnichenko, Elena V Vorontsova, Anton V Chechushkov, Kristina E Trifonova, Maria S Fufaeva, Evgeniy I Kretov, Yuri V Mironov, Alexander F Poveshchenko, Kamil Lang, Michael A Shestopalov
Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficially. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re6Q8}(CN)6](4-), where Q = S, Se, Te...
November 6, 2017: Inorganic Chemistry
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