Jiacheng Huang, Mengqing Sun, Menglan Wang, Anning Yu, Huilin Zheng, Chiwen Bu, Jie Zhou, Yu Zhang, Yiting Qiao, Zhenhua Hu
The prevalence of alcohol-related hepatocellular carcinoma (HCC) has been increasing during the last decade. Cancer research requires cell lines suitable for both in vitro and in vivo assays. However, there is a lack of cell lines with a high in vivo metastatic capacity for this HCC subtype. Herein, a new HCC cell line was established, named HCC-ZJ, using cells from a patient diagnosed with alcohol-related HCC. The karyotype of HCC-ZJ was 46, XY, del (p11.2). Whole-exome sequencing identified several genetic variations in HCC-Z that occur frequently in alcohol-associated HCC, such as mutations in TERT , CTNNB1 , ARID1A , CDKN2A , SMARCA2 , and HGF ...
December 2024: Bioengineered