Gianmauro Numico, Federico Castiglione, Cristina Granetto, Ornella Garrone, Gabriella Mariani, Gianna Di Costanzo, Pietro La Ciura, Milena Gasco, Oliviero Ostellino, Gianfranco Porcile, Marco Merlano
Polyethylene glycol-coated (pegylated) liposomal doxorubicin (PLD) is a new formulation of doxorubicin with peculiar pharmacokinetic and pharmacodinamic properties, a favorable toxic profile and a demonstrated activity in solid tumors. We tested PLD in locally advanced or metastatic NSCLC patients, progressed after a platinum-based first-line chemotherapy. PLD was administered at the dose of 35 mg/m(2) every 21 days. After the first six patients had been accrued, due to the low toxicity shown in the first six patients, the dose was escalated to 45 mg/m(2)...
January 2002: Lung Cancer: Journal of the International Association for the Study of Lung Cancer