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https://www.readbyqxmd.com/read/29782395/pull-out-of-upper-thoracic-pedicle-screws-can-cause-spinal-canal-encroachment-in-growing-rod-treatment
#1
Senol Bekmez, Aykut Kocyigit, Zeynep Deniz Olgun, Mehmet Ayvaz, Halil Gokhan Demirkiran, Ergun Karaagaoglu, Muharrem Yazici
BACKGROUND: Proximal foundation failure is a common complication of growing rod (GR) treatment for early-onset scoliosis. Spinal canal encroachment due to pull-out of pedicle screw used as proximal foundation has been anecdotally reported in GR patients. The aim of this study is to report the prevalence of spinal canal encroachment of pedicle screws in GR treatment and determine risk factors using a single-center cohort. METHODS: Inclusion criteria were: (1) GR for early-onset scoliosis and (2) pull-out of at least 1 proximal anchor pedicle screw...
May 4, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29762338/incidence-and-risk-factors-for-instrumentation-related-complications-after-scoliosis-surgery-in-pediatric-patients-with-nf-1
#2
Ziming Yao, Hao Li, Xuejun Zhang, Chengxin Li, Xinyu Qi
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To assess the incidence and risk factors of instrumentation-related complication (IRC) in pediatric patients surgically treated for neurofibromatosis type 1 (NF-1) dystrophic scoliosis. SUMMARY OF BACKGROUND DATA: Surgical management including growing rods technique and early definitive fusion has been recommended to avoid progression of NF-1 scoliosis. However, no study has yet investigated the incidence and risk factors of IRC in these surgical interventions...
May 14, 2018: Spine
https://www.readbyqxmd.com/read/29755901/emerging-cellular-therapies-for-glioblastoma-multiforme
#3
REVIEW
Paul J Choi, R Shane Tubbs, Rod J Oskouian
Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, making it resistant to current first-line chemotherapy with temozolomide, an alkylating agent. Despite many years of research, GBM remains poorly responsive to multiple available therapies, giving GBM patients, who receive the conventional combination of chemoradiotherapies and surgical resection, a dismal prognosis...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29754715/assembly-kinetics-of-vimentin-tetramers-to-unit-length-filaments-a-stopped-flow-study
#4
Norbert Mücke, Lara Kämmerer, Stefan Winheim, Robert Kirmse, Jan Krieger, Maria Mildenberger, Jochen Baßler, Ed Hurt, Wolfgang H Goldmann, Ueli Aebi, Katalin Toth, Jörg Langowski, Harald Herrmann
Intermediate filaments (IFs) are principal components of the cytoskeleton, a dynamic integrated system of structural proteins that provides the functional architecture of metazoan cells. They are major contributors to the elasticity of cells and tissues due to their high mechanical stability and intrinsic flexibility. The basic building block for the assembly of IFs is a rod-like, 60-nm-long tetrameric complex made from two antiparallel, half-staggered coiled coils. In low ionic strength, tetramers form stable complexes that rapidly assemble into filaments upon raising the ionic strength...
May 10, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29752017/natronobiforma-cellulositropha-gen-nov-sp-nov-a-novel-haloalkaliphilic-member-of-the-family-natrialbaceae-class-halobacteria-from-hypersaline-alkaline-lakes
#5
Dimitry Y Sorokin, Tatiana V Khijniak, Nadezhda A Kostrikina, Alexander G Elcheninov, Stepan V Toshchakov, Nicole J Bale, Jaap S Sinninghe Damsté, Ilya V Kublanov
Six strains of extremely halophilic and alkaliphilic euryarchaea were enriched and isolated in pure culture from surface brines and sediments of hypersaline alkaline lakes in various geographical locations with various forms of insoluble cellulose as growth substrate. The cells are mostly flat motile rods with a thin monolayer cell wall while growing on cellobiose. In contrast, the cells growing with cellulose are mostly nonmotile cocci covered with a thick external EPS layer. The isolates, designated AArcel, are obligate aerobic heterotrophs with a narrow substrate spectrum...
April 27, 2018: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29741202/identification-of-protein-kinase-c-%C3%AE-and-tyrosine-hydroxylase-immunoreactive-cells-in-the-microbat-retina
#6
Eun-Bee Park, Joo-Yeong Jeon, Chang-Jin Jeon
A growing number of studies have revealed the functional neuroarchitecture of the microbat retina and suggested that microbats can see using their eyes. To better understand the organization of the microbat retina, quantitative analysis of protein kinase C alpha (PKCα)- and tyrosine hydroxylase (TH)-immunoreactive (IR) cells was conducted on the greater horseshoe bat (Rhinolophus ferrumequinum) retina. As a result, PKCα immunoreactivity was observed in rod bipolar cells, consistent with previous studies on other mammalian retinas...
May 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29735144/construct-levels-to-anchored-levels-ratio-and-rod-diameter-are-associated-with-implant-related-complications-in-traditional-growing-rods
#7
Pooria Hosseini, Behrooz A Akbarnia, Stacie Nguyen, Jeff Pawelek, John Emans, Peter F Sturm, Paul D Sponseller
INTRODUCTION: In addition to patient characteristics, consideration of length of construct to number of anchored levels ratio and rod diameter should be a part of preoperative planning to minimize implant-related complications (IRCs). IRCs including rod breakage, anchor dislodgement, and pullout are among the most common adverse events in traditional growing rods (TGRs). The current study hypothesized that anchor type and configuration are associated with IRC. METHODS: Patients with (1) age ≤10 years at surgery; (2) spine-based dual TGR; (3) minimum 2-year follow-up; and (4) available imaging...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735143/radiographic-outcome-differences-in-distraction-based-growing-rod-constructs-using-tandem-versus-wedding-band-connectors
#8
Matthew E Oetgen, Allison Matthews, Yunfei Wang, Laurel Blakemore, Jeff Pawelek, Anna McClung, Paul Sponseller, Francisco Sanchez Perez-Grueso, Behrooz Akbarnia
STUDY DESIGN: Comparative cohort study. OBJECTIVE: To compare coronal deformity control, lengthening efficacy, and sagittal alignment between distraction-based growing rod constructs utilizing tandem versus wedding band connectors. SUMMARY OF BACKGROUND DATA: Different construct designs exist for growing rod treatment of early-onset scoliosis. All use a version of a rod connector, with the two main types being tandem and wedding band. Little data exist to quantify the impact of connector choice on radiographic outcomes of treatment...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735141/expert-consensus-and-equipoise-planning-a-randomized-controlled-trial-of-magnetically-controlled-growing-rods
#9
Nicholas Feinberg, Hiroko Matsumoto, Chun Wai Hung, Tricia St Hilaire, Jeff Pawelek, Jeffrey R Sawyer, Behrooz A Akbarnia, David L Skaggs, Benjamin D Roye, David P Roye, Michael G Vitale
STUDY DESIGN: Expert consensus building using combined Delphi method and Nominal group technique. OBJECTIVES: To identify the current state of equipoise surrounding the use of magnetically controlled growing rods (MCGRs) and to determine consensus for planning a randomized controlled trial (RCT) with MCGRs. BACKGROUND: The use of MCGRs for the treatment of early-onset scoliosis (EOS) is a new technology. Optimal use has not been thoroughly investigated and much uncertainty exists...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735140/surgeon-survey-shows-no-adverse-events-with-mri-in-patients-with-magnetically-controlled-growing-rods-mcgrs
#10
Regina P Woon, Lindsay M Andras, Hilali Noordeen, Stephen Morris, John Hutchinson, Suken A Shah, Jeff Pawelek, Charles E Johnston, David L Skaggs
STUDY DESIGN: Surgeon survey. OBJECTIVES: To determine if magnetic resonance imaging (MRI) following implantation of magnetically controlled growing rods (MCGRs) is associated with any adverse events. SUMMARY OF BACKGROUND DATA: Magnetically controlled growing rods have been shown to reduce the need for repeated surgical procedures and improve costs when compared to traditional growing rods, but concerns about MRI compatibility exist. MRIs are often clinically indicated in the EOS population...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735139/cadaveric-study-of-the-safety-and-device-functionality-of-magnetically-controlled-growing-rods-after-exposure-to-magnetic-resonance-imaging
#11
Selina Poon, Yen Hsun Chen, Stephen F Wendolowski, Adam Graver, Ryan Nixon, Terry Amaral, Jon-Paul DiMauro, Daniel M Walz, Rachel C Gecelter, Daniel A Grande
STUDY DESIGN: Cadaveric study. OBJECTIVE: To establish the safety and efficacy of magnetically controlled growing rods (MCGRs) after magnetic resonance imaging (MRI) exposure. SUMMARY OF BACKGROUND DATA: MCGRs are new and promising devices for the treatment of early-onset scoliosis (EOS). A significant percentage of EOS patients have concurrent spinal abnormalities that need to be monitored with MRI. There are major concerns of the MRI compatibility of MCGRs because of the reliance of the lengthening mechanism on strongly ferromagnetic actuators...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29721828/characterization-of-flavobacterium-aquimarinum-sp-nov-a-halotolerant-bacterium-isolated-from-seawater
#12
Sylvia Kristyanto, Tuan Manh Nguyen, Dhiraj Kumar Chaudhary, Sang-Seob Lee, Jaisoo Kim
A novel, aerobic, Gram-stain-negative, non-motile, non-spore forming, rod-shaped bacterium, designated strain Dol 15-39T , was isolated from a seawater sample near Geoje Island in the South Sea, Republic of Korea. The strain was found to be oxidase-negative and catalase-positive. The isolate was observed to grow at temperatures from 4 to 37°C, at salinities of up to 7%, and at pH levels from 6 to 9; moreover, it was not able to degrade starch, DNA, esculin, or tyrosine. Phylogenetic analysis based on 16S rRNA gene sequences showed that Dol 15-39T was most closely related to Flavobacterium jumunjinense HME7102T with a sequence similarity of 97...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29689193/mechanosensation-dynamically-coordinates-polar-growth-and-cell-wall-assembly-to-promote-cell-survival
#13
Valeria Davì, Hirokazu Tanimoto, Dmitry Ershov, Armin Haupt, Henry De Belly, Rémi Le Borgne, Etienne Couturier, Arezki Boudaoud, Nicolas Minc
How growing cells cope with size expansion while ensuring mechanical integrity is not known. In walled cells, such as those of microbes and plants, growth and viability are both supported by a thin and rigid encasing cell wall (CW). We deciphered the dynamic mechanisms controlling wall surface assembly during cell growth, using a sub-resolution microscopy approach to monitor CW thickness in live rod-shaped fission yeast cells. We found that polar cell growth yielded wall thinning and that thickness negatively influenced growth...
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29676726/rhodohalobacter-barkolensis-sp-nov-isolated-from-a-saline-lake-and-emended-description-of-the-genus-rhodohalobacter
#14
Shuai-Bo Han, Yang-Huan Yu, Zhao Ju, Yu Li, Ran Zhang, Xin-Jun Hou, Xin-Yuan Ma, Xiao-Yun Yu, Cong Sun, Min Wu
A Gram-stain-negative, non-motile, aerobic, rod-shaped bacterium, designated 15182T , was isolated from a saline lake in China. The novel strain 15182T was able to grow at 10-40 °C (optimum, 37 °C), pH 7.0-8.0 (optimum, 7.5) and with 0.5-4 % NaCl (optimum, 2-3 %, w/v). The phylogenetic analysis based on 16S rRNA gene sequences revealed that strain 15182T was most closely related to the genus Rhodohalobacter by sharing the highest sequence similarity of 97.0 % with Rhodohalobacter halophilus JZ3C29T ...
April 20, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29675673/systematic-review-of-the-complications-associated-with-magnetically-controlled-growing-rods-for-the-treatment-of-early-onset-scoliosis
#15
REVIEW
Chrishan Thakar, David Christopher Kieser, Mihai Mardare, Shahnawaz Haleem, Jeremy Fairbank, Colin Nnadi
PURPOSE: To analyse the complication profile of magnetically controlled growing rods (MCGRs) in early onset scoliosis (EOS). METHODS: This is a systematic review using PUBMED, Medline, Embase, Google Scholar and the Cochrane Library (keywords: MAGEC, Magnetically controlled growing rods and EOS) of all studies written in English with a minimum of five patients and a 1-year follow-up. We evaluated coronal correction, growth progression (T1-S1, T1-T12) and complications...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29664362/roseovarius-ramblicola-sp-nov-a-moderately-halophilic-bacterium-isolated-from-saline-soil-in-spain
#16
David J Castro, Isabel Cerezo, Inmaculada Sampedro, Fernando Martínez-Checa
Strain D15T was isolated from a soil sample taken from Rambla Salada (Murcia), south-eastern Spain, by using the dilution-to-extinction method. The strain, a Gram-stain-negative aerobic bacteria, is non-motile, ovoid- or rod-shaped, catalase- and oxidase-positive, and grows at NaCl concentrations within the range 0.5-10 % (w/v) [optimum 3 % (w/v)], at 5-30 °C (optimum 28 °C) and at pH 6-9 (optimum pH 7.0). The 16S rRNA gene sequence indicates that it belongs to the genus Roseovarius in the class Alphaproteobacteria...
April 17, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29664361/pseudaeromonas-paramecii-sp-nov-isolated-from-the-ciliate-paramecium-caudatum-and-emendation-of-the-genus-pseudaeromonas
#17
Sumi Akter, Mann Kyoon Shin
A Gram-stain-negative, oxidase-negative and catalase-negative, motile, rod-shaped bacterial strain, designated PCS8T , hosted by the ciliate Paramecium caudatum was investigated by using a polyphasic approach. Strain PCS8T was observed to be able to grow at 12-44 °C (optimum, 36-37 °C), at pH 6.0-10.0 (optimum, 7.0) and in the presence of 0-3 % NaCl (optimum, 1-2 %). It could hydrolyse starch and aesculin and produce acid from d-sorbitol, myo-inositol, glycerol and l-rhamnose. The sequence similarity of the new isolate was 96...
April 17, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29659709/progress-in-single-access-information-systems-for-wheat-and-rice-crop-improvement
#18
Armin Scheben, Chon-Kit Kenneth Chan, Locedie Mansueto, Ramil Mauleon, Pierre Larmande, Nickolai Alexandrov, Rod A Wing, Kenneth L McNally, Hadi Quesneville, David Edwards
Improving productivity of the staple crops wheat and rice is essential to feed the growing global population, particularly in the context of a changing climate. However, current rates of yield gain are insufficient to support the predicted population growth. New approaches are required to accelerate the breeding process, and many of these are driven by the application of large-scale crop data. To leverage the substantial volumes and types of data that can be applied for precision breeding, the wheat and rice research communities are working towards the development of integrated systems to access and standardize the dispersed, heterogeneous available data...
April 5, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29657440/magnetic-growth-modulation-in-orthopaedic-and-spine-surgery
#19
REVIEW
Adam E M Eltorai, Carolina Fuentes
Purpose: To examine distraction-based methods for treatment of early onset scoliosis (EOS), focusing on the magnetically controlled growing rod system (MCGR) relative to traditional growing rod system (TGR). To briefly discuss internal magnetically controlled nails for bone lengthening as another application of magnetic growth modulation. Results: Relative to TGR, MCGR involves fewer complications related to infection and general anesthesia because of fewer successive surgeries required...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29649090/reliability-of-rod-lengthening-thoracic-and-spino-pelvic-measurements-on-biplanar-stereoradiography-in-patients-treated-with-magnetically-controlled-growing-rods
#20
Peter Obid, Karen Kar Lum Yiu, Kenneth Mc Cheung, Kenny Kwan, Michael Ruf, Jason Pui Yin Cheung
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To assess the inter- and intraobserver reliability of thoracic, spino-pelvic and rod lengthening measurements made on biplanar spinal stereoradiography (EOS imaging) in children treated with magnetically controlled growing rod (MCGR). SUMMARY OF BACKGROUND DATA: MCGR treatment aims to gain spine length while gradually correcting the spinal deformity. Monitoring thoracic and spino-pelvic parameters are crucial for successful management...
April 11, 2018: Spine
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