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memantine systematic analysis

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https://www.readbyqxmd.com/read/27726067/apathy-in-dementia-systematic-review-of-recent-evidence-on-pharmacological-treatments
#1
Fleur Harrison, Liesbeth Aerts, Henry Brodaty
Increasing recognition that apathy is one of the most prevalent behavioral and psychological symptoms of dementia and causes substantial caregiver distress has led to trials evaluating psychosocial and pharmacological treatments of apathy in dementia. We evaluated evidence of the efficacy of pharmacotherapies for apathy in dementia from studies since 2013. Previously reported benefits of acetylcholinesterase inhibitors and memantine were not replicated in recent studies. Antidepressants had mixed results with positive effects for apathy shown only for agomelatine, while stimulants, analgesics, and oxytocin study results were inconclusive...
November 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/26601726/drug-and-exercise-treatment-of-alzheimer-disease-and-mild-cognitive-impairment-a-systematic-review-and-meta-analysis-of-effects-on-cognition-in-randomized-controlled-trials
#2
REVIEW
Andreas Ströhle, Dietlinde K Schmidt, Florian Schultz, Nina Fricke, Theresa Staden, Rainer Hellweg, Josef Priller, Michael A Rapp, Nina Rieckmann
OBJECTIVE: Demographic changes are increasing the pressure to improve therapeutic strategies against cognitive decline in Alzheimer disease (AD) and mild cognitive impairment (MCI). Besides drug treatment, physical activity seems to be a promising intervention target as epidemiological and clinical studies suggest beneficial effects of exercise training on cognition. Using comparable inclusion and exclusion criteria, we analyzed the efficacy of drug therapy (cholinesterase inhibitors, memantine, and Ginkgo biloba) and exercise interventions for improving cognition in AD and MCI populations...
December 2015: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26415966/ketamine-and-other-glutamate-receptor-modulators-for-depression-in-bipolar-disorder-in-adults
#3
REVIEW
Tayla L McCloud, Caroline Caddy, Janina Jochim, Jennifer M Rendell, Peter R Diamond, Claire Shuttleworth, Daniel Brett, Ben H Amit, Rupert McShane, Layla Hamadi, Keith Hawton, Andrea Cipriani
BACKGROUND: There is emerging evidence that glutamatergic system dysfunction might play an important role in the pathophysiology of bipolar depression. This review focuses on the use of glutamate receptor modulators for depression in bipolar disorder. OBJECTIVES: 1. To assess the effects of ketamine and other glutamate receptor modulators in alleviating the acute symptoms of depression in people with bipolar disorder.2. To review the acceptability of ketamine and other glutamate receptor modulators in people with bipolar disorder who are experiencing acute depression symptoms...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26085043/pharmacological-management-of-lewy-body-dementia-a-systematic-review-and-meta-analysis
#4
REVIEW
Chris Stinton, Ian McKeith, John-Paul Taylor, Louise Lafortune, Eneida Mioshi, Elijah Mak, Victoria Cambridge, James Mason, Alan Thomas, John T O'Brien
OBJECTIVE: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia. METHOD: Studies were identified through bibliographic databases, trials registers, gray literature, reference lists, and experts. The authors used the search terms "Lewy or parkinson" and "dementia" through March 2015 and used the following inclusion criteria: participants with diagnoses of Lewy body dementia, dementia with Lewy bodies, or Parkinson's disease dementia (or participants' caregivers); investigation of pharmacological management strategies; outcome measures and test scores reported...
August 1, 2015: American Journal of Psychiatry
https://www.readbyqxmd.com/read/25860130/memantine-monotherapy-for-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#5
REVIEW
Shinji Matsunaga, Taro Kishi, Nakao Iwata
BACKGROUND: We performed an updated meta-analysis of randomized placebo-controlled trials testing memantine monotherapy for patients with Alzheimer's disease (AD). METHODS: The meta-analysis included randomized controlled trials of memantine monotherapy for AD, omitting those in which patients were also administered a cholinesterase inhibitor. Cognitive function, activities of daily living, behavioral disturbances, global function, stage of dementia, drug discontinuation rate, and individual side effects were compared between memantine monotherapy and placebo groups...
2015: PloS One
https://www.readbyqxmd.com/read/25808982/efns-ens-ean-guideline-on-concomitant-use-of-cholinesterase-inhibitors-and-memantine-in-moderate-to-severe-alzheimer-s-disease
#6
REVIEW
R Schmidt, E Hofer, F H Bouwman, K Buerger, C Cordonnier, T Fladby, D Galimberti, J Georges, M T Heneka, J Hort, J Laczó, J L Molinuevo, J T O'Brien, D Religa, P Scheltens, J M Schott, S Sorbi
BACKGROUND AND PURPOSE: Previous studies have indicated clinical benefits of a combination of cholinesterase inhibitors (ChEI) and memantine over ChEI monotherapy in Alzheimer's disease (AD). Our objective was the development of guidelines on the question of whether combined ChEI/memantine treatment rather than ChEI alone should be used in patients with moderate to severe AD to improve global clinical impression (GCI), cognition, behaviour and activities of daily living (ADL). METHODS: A systematic review and meta-analysis of randomized controlled trials based on a literature search in ALOIS, the register of the Cochrane Dementia and Cognitive Improvement Group, was carried out with subsequent guideline development according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system...
June 2015: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/25790674/-treatment-of-vascular-dementia-by-chinese-herbal-medicine-a-systematic-review-of-randomized-controlled-trials-of-clinical-studies
#7
REVIEW
Wen-Jia Jian, Jing Shi, Jin-Zhou Tian, Jing-Nian Ni
OBJECTIVE: Chinese herbal medicine has been extensively used in the treatment of vascular dementia (VaD), but lacked systematic review on its efficacy and safety. So we conducted a systematic review to assess the efficacy and safety of Chinese herbal medicine in treating VaD. METHODS: CNKI, CBM, PubMed, and Wiley Online Library were retrieved for randomized trials (RCTs) on Chinese herbal medicine treating VaD patients. Randomized parallel control trials by taking Chinese herbal medicine as one treatment method and placebos/cholinesterase inhibitors/Memantine hydrochloride as the control were included...
January 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/25548104/combination-therapy-with-cholinesterase-inhibitors-and-memantine-for-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#8
REVIEW
Shinji Matsunaga, Taro Kishi, Nakao Iwata
BACKGROUND: We performed an updated meta-analysis of randomized controlled trials of combination therapy with cholinesterase inhibitors and memantine in patients with Alzheimer's disease. METHODS: We reviewed cognitive function, activities of daily living, behavioral disturbance, global assessment, discontinuation rate, and individual side effects. RESULTS: Seven studies (total n=2182) were identified. Combination therapy significantly affected behavioral disturbance scores (standardized mean difference=-0...
March 2015: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/25181033/cortical-eeg-oscillations-and-network-connectivity-as-efficacy-indices-for-assessing-drugs-with-cognition-enhancing-potential
#9
A Ahnaou, H Huysmans, T Jacobs, W H I M Drinkenburg
Synchronization of electroencephalographic (EEG) oscillations represents a core mechanism for cortical and subcortical networks, and disturbance in neural synchrony underlies cognitive processing deficits in neurological and neuropsychiatric disorders. Here, we investigated the effects of cognition enhancers (donepezil, rivastigmine, tacrine, galantamine and memantine), which are approved for symptomatic treatment of dementia, on EEG oscillations and network connectivity in conscious rats chronically instrumented with epidural electrodes in different cortical areas...
November 2014: Neuropharmacology
https://www.readbyqxmd.com/read/24987400/important-error-in-systematic-review-and-meta-analysis-of-combination-therapy-with-cholinesterase-inhibitors-and-memantine-in-alzheimer-s-disease-and-other-dementias-by-muayqil-and-camicioli
#10
Pierre N Tariot, Yvonne Wirth, Stephen M Graham, Michael Tocco, Jasmine Fokkens
No abstract text is available yet for this article.
May 2014: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/24876182/pharmacological-treatment-of-neuropsychiatric-symptoms-in-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#11
REVIEW
Jun Wang, Jin-Tai Yu, Hui-Fu Wang, Xiang-Fei Meng, Chong Wang, Chen-Chen Tan, Lan Tan
BACKGROUND: A wide variety of pharmacological agents are used in the management of neuropsychiatric symptoms, which are common in Alzheimer's disease (AD), but results from randomised controlled trials (RCTs) on the efficacy and safety of these agents are conflicting. OBJECTIVES: To quantify the efficacy and safety of pharmacological treatment on neuropsychiatric symptoms in AD patients. METHODS: Systematic review and meta-analysis of RCTs comparing pharmacological agents with placebo on Neuropsychiatric Inventory (NPI) and safety outcomes in AD patients with neuropsychiatric symptoms...
January 2015: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/24828899/efficacy-and-safety-of-cholinesterase-inhibitors-and-memantine-in-cognitive-impairment-in-parkinson-s-disease-parkinson-s-disease-dementia-and-dementia-with-lewy-bodies-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#12
REVIEW
Hui-Fu Wang, Jin-Tai Yu, Shao-Wen Tang, Teng Jiang, Chen-Chen Tan, Xiang-Fei Meng, Chong Wang, Meng-Shan Tan, Lan Tan
OBJECTIVE: Recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to Parkinson's disease (CIND-PD or PDD) and dementia with Lewy bodies (DLB) were completed. Here, we systematically reviewed the studies (including the recent reports) to provide updated evidence for the treatments of CIND-PD, PDD and DLB. METHODS: We searched Cochrane Dementia and Cognitive Improvement Group Specialised Register, Pubmed, Embase, and other sources for eligible trials...
February 2015: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/24806974/changes-in-gait-variability-with-anti-dementia-drugs-a-systematic-review-and-meta-analysis
#13
O Beauchet, C P Launay, G Allali, C Annweiler
BACKGROUND: Studies have examined the effects of anti-dementia drugs on gait performance. No structured critical evaluation of these studies has been done so far. The objectives of this study were (1) to perform a qualitative analysis of all published studies on changes in stride time variability (STV) with anti-dementia drugs among patients with Alzheimer disease through a systematic review, and (2) to quantitatively synthesize anti-dementia drug-related changes in STV. METHODS: An English and French MEDLINE search was conducted on November 2013, with no limit of date, using the Medical Subject Headings term "pharmaceutical preparations" combined with "delirium", "dementia", "amnestic", "cognitive disorders" AND "gait" OR "gait disorders, neurologic" OR "gait apraxia"...
June 2014: CNS Drugs
https://www.readbyqxmd.com/read/24662102/efficacy-and-safety-of-donepezil-galantamine-rivastigmine-and-memantine-for-the-treatment-of-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#14
REVIEW
Chen-Chen Tan, Jin-Tai Yu, Hui-Fu Wang, Meng-Shan Tan, Xiang-Fei Meng, Chong Wang, Teng Jiang, Xi-Chen Zhu, Lan Tan
BACKGROUND: The role of currently available drugs for Alzheimer's disease (AD) has been controversial, with some national formularies restricting their use, and health economists questioning whether the small clinical effects are economically worthwhile. OBJECTIVE: To estimate the efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of AD. METHODS: Double-blind, placebo-controlled, with random assignment to a cholinesterase inhibitor or memantine trials were included into the pooled studies...
2014: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/24406251/memantine-for-lewy-body-disorders-systematic-review-and-meta-analysis
#15
REVIEW
Shinji Matsunaga, Taro Kishi, Nakao Iwata
OBJECTIVE: To clarify whether memantine is more efficacious in several outcomes and safer than placebo in patients with Lewy body disorders, we performed a meta-analysis of memantine in patients with Lewy body disorders. METHODS: The meta-analysis included randomized controlled trials of memantine for Lewy body disorders in all patients with Lewy body disorders. Motor function, activities of daily living, Neuropsychiatric Inventory, Mini-Mental State Exam, discontinuation rate, and individual side effects were evaluated...
April 2015: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/24224475/phantom-limb-pain-a-systematic-neuroanatomical-based-review-of-pharmacologic-treatment
#16
REVIEW
Zachary McCormick, George Chang-Chien, Benjamin Marshall, Mark Huang, R Norman Harden
OBJECTIVE: Review the current evidence-based pharmacotherapy for phantom limb pain (PLP) in the context of the current understanding of the pathophysiology of this condition. DESIGN: We conducted a systematic review of original research papers specifically investigating the pharmacologic treatment of PLP. Literature was sourced from PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL). Studies with animals, "neuropathic" but not "phantom limb" pain, or without pain scores and/or functional measures as primary outcomes were excluded...
February 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/24164931/pharmacological-treatments-for-frontotemporal-dementias-a-systematic-review-of-randomized-controlled-trials
#17
REVIEW
Maria Nardell, Rajesh R Tampi
The objective of this review is to summarize the current data on the pharmacological treatments for frontotemporal dementias from randomized controlled trials. A systematic search of 4 major databases, PubMed, Medline, PsychINFO and Cochrane, found a total of 9 randomized controlled, double-blinded clinical trials. Of these, 2 trials used the selective serotonin reuptake inhibitor (SSRI), paroxetine; 1 trial used trazodone; 2 trials used stimulants (methylphenidate and dextroamphetamine); 1 trial used the acetylcholinesterase inhibitor, galantamine; 2 trials used the N-methyl-d-aspartate antagonist, memantine; and 1 trial used the neuropeptide oxytocin...
March 2014: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/24043661/efficacy-and-safety-of-cognitive-enhancers-for-patients-with-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#18
REVIEW
Andrea C Tricco, Charlene Soobiah, Shirra Berliner, Joanne M Ho, Carmen H Ng, Huda M Ashoor, Maggie H Chen, Brenda Hemmelgarn, Sharon E Straus
BACKGROUND: Cognitive enhancers, including cholinesterase inhibitors and memantine, are used to treat dementia, but their effectiveness for mild cognitive impairment is unclear. We conducted a systematic review to examine the efficacy and safety of cognitive enhancers for mild cognitive impairment. METHODS: Our eligibility criteria were studies of the effects of donepezil, rivastigmine, galantamine or memantine on mild cognitive impairment reporting cognition, function, behaviour, global status, and mortality or harms...
November 5, 2013: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/23692933/nmda-receptor-antagonists-interventions-in-schizophrenia-meta-analysis-of-randomized-placebo-controlled-trials
#19
Taro Kishi, Nakao Iwata
BACKGROUND: We examined whether N-methyl d-aspartate (NMDA) receptor antagonists as adjunctive therapy have therapeutic potential for schizophrenia treatment. METHOD: Systematic review of PubMed, Cochrane Library, PsycINFO and Google Scholar up until October 2012 and meta-analysis of randomized placebo-controlled trials were performed. Risk ratio (RR), 95% confidence intervals (CI), numbers-needed-to-harm (NNH), and standardized mean difference (SMD) were calculated...
September 2013: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/23635410/effectiveness-and-safety-of-memantine-treatment-for-alzheimer-s-disease
#20
REVIEW
Zhendong Yang, Xiangyu Zhou, Qi Zhang
BACKGROUND/OBJECTIVE: Memantine is approved as a treatment for moderate to severe Alzheimer's disease (AD). However, recent studies report that memantine is harmful for AD patients in several ways. This paper will systematically review all the available studies to provide an update regarding memantine as a treatment for AD. METHOD: Two authors queried nine databases containing literature published prior to September 15, 2012 and determined eligible studies based on the inclusion criteria...
2013: Journal of Alzheimer's Disease: JAD
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