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https://www.readbyqxmd.com/read/28351094/overexpression-of-lncrna-hotair-is-associated-with-poor-prognosis-in-thyroid-carcinoma-a-study-based-on-tcga-and-geo-data
#1
Hong-Mei Li, Hong Yang, Dong-Yue Wen, Yi-Huan Luo, Chun-Yan Liang, Deng-Hua Pan, Wei Ma, Gang Chen, Yun He, Jun-Qiang Chen
The role of long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in thyroid carcinoma (TC) remains unclear. The current study was aimed to assess the clinical value of HOTAIR expression levels in TC based on publically available data and to evaluate its potential signaling pathways. The expression data of HOTAIR and clinical information concerning TC were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), respectively. Furthermore, 3 online biological databases, Starbase, Cbioportal, and Multi Experiment Matrix, were used to identify HOTAIR-related genes in TC...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351087/how-can-environmental-factors-contribute-to-the-incidence-of-thyroid-cancer
#2
Christian A Koch
No abstract text is available yet for this article.
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351086/independent-risk-factors-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma
#3
Xiaolong Yu, Xuejia Song, Wenhai Sun, Shihua Zhao, Jiajun Zhao, Yan-Gang Wang
The incidence of papillary thyroid microcarcinoma (PTMC) has risen rapidly in recent years, and PTMC patients with central lymph node metastasis (CLNM) usually have poor prognosis. Independent risk factors predicting CLNM in PTMC have not been well understood. The aim of our study was to identify useful clinicopathological risk factors predicting CLNM in PTMC patients. This was a retrospective study of 917 patients with PTMC treated with surgery from January 2014 to December 2015 in our hospital. The relationship between clinicopathological factors and CLNM was analyzed to identify those factors predicting CLNM in PTMC...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351085/thyroid-function-and-metabolic-syndrome-a-population-based-thyroid-study
#4
Ladan Mehran, Atieh Amouzegar, Parnian Kheirkhah Rahimabad, Maryam Tohidi, Zhale Tahmasebinejad, Fereidoun Azizi
The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged≥20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5 422 subjects to be investigated...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28350954/integrating-drug-s-mode-of-action-into-quantitative-structure-activity-relationships-for-improved-prediction-of-drug-induced-liver-injury
#5
Leihong Wu, Zhichao Liu, Scott S Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Zhihua Xu, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is complex in mechanism. Different drugs could undergo different mechanisms but result in the same DILI type while the same drug could lead to different DILI types via different mechanisms. Therefore, predicting a drug's potential for DILI should take its underlying mechanisms into consideration. To achieve that, we constructed a novel approach by incorporating drug's Mode of Action (MOA) into Quantitative Structure-Activity Relationship (QSAR) modeling. This MOA-DILI approach was examined using a dataset of 333 drugs...
March 28, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28350750/family-history-comorbidity-smoking-and-other-risk-factors-in-microscopic-colitis-a-case-control-study
#6
Anna Wickbom, Nils Nyhlin, Scott M Montgomery, Johan Bohr, Curt Tysk
OBJECTIVES: Data on heredity, risk factors and comorbidity in microscopic colitis, encompassing collagenous colitis (CC) and lymphocytic colitis (LC), are limited. AIM: The aim was to carry out a case-control study of family history, childhood circumstances, educational level, marital status, smoking and comorbidity in microscopic colitis. METHODS: A postal questionnaire was sent in 2008-2009 to microscopic colitis patients resident in Sweden and three population-based controls per patient, matched for age, sex and municipality...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28350659/first-female-to-male-facial-confirmation-surgery-with-description-of-a-new-procedure-for-masculinization-of-the-thyroid-cartilage-adam-s-apple
#7
Jordan C Deschamps-Braly, Caitlin L Sacher, Jennifer Fick, Douglas K Ousterhout
Although male-to-female transgender patients commonly seek facial feminization surgery, facial masculinization surgery in the female-to-male transgender population is unreported in the literature. This report documents the first known female-to-male facial masculinization surgery, including a new technique for creating an "Adam's apple" to enhance the facial masculine appearance of a natal female. The authors "reversed" the methods typically used to feminize male facial features, and modified the forehead, nose, and chin to masculinize the patient's natal female facial features...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350538/possible-effects-of-neonatal-vitamin-b12-status-on-tsh-screening-program-a-cross-sectional-study-from-turkey
#8
Zerrin Onal, Seda Balkaya, Atilla Ersen, Neval Mutlu, Hasan Onal, Erdal Adal
BACKGROUND: In this study we evaluated whether vitamin B12 deficiency affects neonatal screening (NS) for congenital hypothyroidism (CH). METHODS: A cross-sectional study conducted from 2010 to 2011. A total of 10,740 infants were born in our hospital in this period. Thyroid-stimulating hormone (TSH) was tested for NS and neonates with abnormal screening results (TSH>20 mIU/L) were re-examined. Two hundred and twenty-nine re-called subjects (re-call rate 2.3%) were compared to 77 randomly selected newborns with normal TSH screening among these term newborns in terms of serum TSH, free T4, vitamin B12 and homocysteine status...
March 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28346766/maternal-thyroid-parameters-in-pregnant-women-with-different-ethnic-backgrounds-do-ethnicity-specific-reference-ranges-improve-the-diagnosis-of-subclinical-hypothyroidism
#9
Flora Veltri, Julie Belhomme, Pierre Kleynen, Lidia Grabczan, Serge Rozenberg, Thierry Pepersack, Kris Poppe
OBJECTIVE: Guidelines on the management of thyroid dysfunction during pregnancy have recently been updated and, for the diagnosis of subclinical hypothyroidism (SCH), a TSH upper reference limit (cutoff) of 4.0 mIU/L has been proposed when no institutional values are available. It is also suggested that serum TSH and thyroid autoimmunity (TAI) may be different according to the ethnic background of the women. We therefore determined the prevalence of TAI and SCH in pregnant women with different ethnic backgrounds and, to define SCH, we used different first trimester TSH upper reference cutoffs (institutional, ethnicity-specific, 2...
March 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28346729/comparison-of-the-safety-of-electrotome-harmonic-scalpel-and-ligasure-for-management-of-thyroid-surgery
#10
Xiaodong Yang, Jian Cao, Yichao Yan, Fangfang Liu, Tao Li, Long Han, Chunxiang Ye, Shuying Zheng, Shan Wang, Yingjiang Ye, Kewei Jiang
BACKGROUND: Energy-based surgical devices, including electrotome, the Harmonic scalpel, and LigaSure, have been widely applied in thyroid surgery, although a comparison of their safety and efficacy has not been reported yet. In this study, we investigated the feasibility of using hemostatic energy-based surgical devices during thyroid surgery in a canine model. METHODS: Twenty-four beagle dogs were randomly divided into the following groups: electrotome (30 kW), electrotome (15 kW), the Harmonic scalpel (output level 3), and LigaSure (middle gear)...
March 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/28346249/usefulness-of-68ga-dota-rgd-%C3%AE-v%C3%AE-3-pet-ct-imaging-in-thyroglobulin-elevation-with-negative-iodine-scintigraphy
#11
Rakhee Vatsa, Jaya Shykla, Bhagwant Rai Mittal, Priya Bhusari, Apurva Sood, Rajender Kumar Basher, Anish Bhattacharya
TENIS (thyroglobulin elevation with negative iodine scintigraphy) syndrome in patients with differentiated thyroid carcinoma is not a rare finding. In such patients, F-FDG PET/CT can help in disease evaluation. RGD tripeptide, used for imaging angiogenesis, may also help in disease detection in patients with negative radioiodine whole-body scan. We present 1 such case in whom Ga-RGD tripeptide imaging was helpful in disease detection in the setting of negative radioiodine whole-body scan.
March 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28345837/association-of-the-asp1312gly-thyroglobulin-gene-polymorphism-with-susceptibility-to-differentiated-thyroid-cancer-in-an-iranian-population
#12
Maryam Abidi, Shima Fayaz, Pezhman Fard Esfahani
Background and aim: While the causes of thyroid cancer in most patients remain largely unknown, it has recently been reported that there may be links to particular chromosome regions. In particular, polymorphisms (SNPs) in the thyroglobulin (TG) gene could be susceptibility factors. Methods: In this case-control study, any association of the Asp1312Gly single nucleotide polymorphism (SNP) in the TG gene (rs2069556) with susceptibility to differentiated thyroid cancer (DTC) was investigated among 103 Iranian patients and 100 controls who had no history of any type of cancer...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345543/use-of-first-phase-insulin-secretion-in-early-diagnosis-of-thyroid-diabetes-and-type-2-diabetes-mellitus
#13
Li-Heng Meng, Yao Huang, Jia Zhou, Xing-Huan Liang, Jing Xian, Li Li, Ying-Fen Qin
BACKGROUND: A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus (T2DM) has been reported. Therefore, this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes (TDM) and T2DM. METHODS: In total, 101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance (TNGT), hyperthyroidism with impaired glucose regulation (TIGR), and diabetes (TDM) groups...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28344960/thyroid-function-antibodies-in-sudanese-women-with-polycystic-ovarian-disease
#14
Shaza Mohammed, Hiba A Awooda, Duria A Rayis, Hamdan Z Hamdan, Ishag Adam, Mohamed F Lutfi
OBJECTIVE: To evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS). METHODS: A case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, and free thyroxine), anti-thyroid peroxidase, and anti-thyroglobulin antibodies were measured...
March 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28344765/new-insights-on-thyroid-hormone-mediated-regulation-of-herpesvirus-infections
#15
REVIEW
Robert W Figliozzi, Feng Chen, S Victor Hsia
Thyroid hormone (T3) has been suggested to participate in the regulation of herpesvirus replication during reactivation. Clinical observations and in vivo experiments suggest that T3 are involved in the suppression of herpes virus replication. In vitro, differentiated LNCaP cells, a human neuron-like cells, further resisted HSV-1 replication upon addition of T3. Previous studies indicate that T3 controlled the expression of several key viral genes via its nuclear receptors in differentiated LNCaP cells. Additional observation showed that differentiated LNCaP cells have active PI3K signaling and inhibitor LY294002 can reverse T3-mediated repression of viral replication...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28344687/disseminated-pancreatic-neuroendocrine-neoplasm-nen-with-an-uncommon-localisation-in-the-central-nervous-system-a-case-report
#16
Joanna Białkowska, Agnieszka Kolasińska-Ćwikła, Dorota Mroczkowska, Mariusz Sowa, Łukasz Grabarczyk, Wojciech Maksymowicz, Andrzej Cichocki, Jarosław B Ćwikła
BACKGROUND: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28344570/tanycytes-as-regulators-of-seasonal-cycles-in-neuroendocrine-function
#17
REVIEW
Jo E Lewis, Francis J P Ebling
Annual cycles of physiology and behavior are highly prevalent in organisms inhabiting temperate and polar regions. Examples in mammals include changes in appetite and body fat composition, hibernation and torpor, growth of antlers, pelage and horns, and seasonal reproduction. The timing of these seasonal cycles reflects an interaction of changing environmental signals, such as daylength, and intrinsic rhythmic processes: circannual clocks. As neuroendocrine signals underlie these rhythmic processes, the focus of most mechanistic studies has been on neuronal systems in the hypothalamus...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28343872/orbital-decompression-for-thyroid-eye-disease
#18
Daniel B Rootman
The literature regarding orbital decompression for thyroid eye disease is vast, spanning multiple specialty areas including neurosurgery, head and neck, maxillofacial and ophthalmic plastic surgery. Although techniques have advanced considerably over the more than 100 years during which this procedure has been performed, the four major approaches remain: transorbital, transcranial, transantral and transnasal. The explosion in literature related to orbital decompression has mostly involved minor technical variations on broader surgical themes...
March 23, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28343733/low-risk-papillary-microcarcinoma-of-the-thyroid-a-review-of-active-surveillance-trials
#19
REVIEW
Y Ito, A Miyauchi, H Oda
Papillary microcarcinoma (PMC) of the thyroid is defined as papillary thyroid carcinoma (PTC) measuring ≤1 cm. Many autopsy studies on subjects who died of non-thyroidal diseases reported latent small thyroid carcinoma in up to 5.2% of the subjects. A mass screening study for thyroid cancer in Japanese adult women detected small thyroid cancer in 3.5% of the examinees. This incidence was close to the incidence of latent thyroid cancer and more than 1000 times the prevalence of clinical thyroid cancer in Japanese women reported at that time...
March 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28343732/ethical-issues-in-non-intervention-trials-for-thyroid-cancer
#20
P Angelos, D M Hartl, J P Shah, I J Nixon, R P Owen, A Rinaldo, J P Rodrigo, A R Shaha, C E Silver, C Suárez, A Ferlito
In recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial...
March 16, 2017: European Journal of Surgical Oncology
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