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https://www.readbyqxmd.com/read/29332066/correlation-between-serum-calcineurin-activity-and-left-ventricular-hypertrophy-in-hypertensive-patients-and-its-clinical-significance
#1
Jia-Li Cao, Yu-Qing Yang, Dookhun Muhammad Nabeel, Ya-Li Sun, Hua-Yi-Yang Zou, Xiang-Qing Kong, Xin-Zheng Lu
OBJECTIVE: The aim of this study is to investigate the correlation between calcineurin (CaN) and hypertension with left ventricular hypertrophy (HLVH) and to evaluate its potential clinical significance. DESIGN: The study involved 160 patients diagnosed with hypertension and 42 controls. Based on the exclusion criteria, 42 were not eligible for this study. The remaining 118 hypertensive patients were categorized into 2 subgroups based on left ventricular mass index and relative ventricular wall thickness: a normal model subgroup with hypertension (HNM) and an HLVH subgroup...
January 13, 2018: Cardiology
https://www.readbyqxmd.com/read/29330420/left-ventricular-hypertrophy-and-cognitive-function-a-systematic-review
#2
C Restrepo, S K Patel, V Rethnam, E Werden, J Ramchand, L Churilov, L M Burrell, A Brodtmann
Cognitive impairment is common in patients with hypertension. Left ventricular hypertrophy (LVH) is recognised as a marker of hypertension-related organ damage and is a strong predictor of coronary artery disease, heart failure and stroke. There is evidence that LVH is independently associated with cognitive impairment, even after adjustment for the presence of hypertension. We conducted a systematic review that examined cognitive impairment in adults with LVH. Independent searches were performed in Ovid MEDLINE, Ovid psycInfo and PubMed with the terms left ventricular hypertrophy and cognition...
January 12, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29324968/long-term-effects-of-an-intensive-lifestyle-intervention-on-electrocardiographic-criteria-for-left-ventricular-hypertrophy-the-look-ahead-trial
#3
Tina E Brinkley, Andrea Anderson, Elsayed Z Soliman, Alain G Bertoni, Frank Greenway, William C Knowler, Stephen P Glasser, Edward S Horton, Mark A Espeland
Background: Left ventricular hypertrophy assessed by electrocardiography (ECG-LVH) is a marker of subclinical cardiac damage and a strong predictor of cardiovascular disease (CVD) events. The prevalence of ECG-LVH is increased in obesity and type 2 diabetes; however, there are no data on the long-term effects of weight loss on ECG-LVH. The purpose of this study was to determine whether an intensive lifestyle intervention reduces ECG-LVH in overweight and obese adults with type 2 diabetes...
January 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29322433/biological-aortic-valve-replacement-advantages-and-optimal-indications-of-stentless-compared-to-stented-valve-substitutes-a-review
#4
REVIEW
Reza Tavakoli, Pichoy Danial, Ahmed Hamid Oudjana, Peiman Jamshidi, Max Gassmann, Pascal Leprince, Guillaume Lebreton
Controversy still surrounds the optimal biological valve substitute for aortic valve replacement. In light of the current literature, we review advantages and optimal indications of stentless compared to stented aortic bio-prostheses. Recent meta-analyses, prospective randomized controlled trials and retrospective studies comparing the most frequently used stentless and stented aortic bio-prostheses were analyzed. In the present review, the types and implantation techniques of the bio-prosthesis that are seldom taken into account by most studies and reviews were integrated in the interpretation of the relevant reports...
January 10, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29319402/interaction-of-metabolic-health-and-obesity-on-subclinical-target-organ-damage
#5
Hyun-Jung Lee, Hack-Lyoung Kim, Jaehoon Chung, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
BACKGROUND: Metabolically healthy obese (MHO) individuals generally show better cardiovascular prognosis compared with metabolically unhealthy counterparts, which may be related to different patterns of target organ damage (TOD). We aimed to investigate the patterns of TOD related to obesity and metabolic unhealthiness. METHODS: A total of 659 Korean adults (mean age, 60.0 ± 11.8 years; male, 51.1%) undergoing health examinations were stratified into four groups according to obesity (body mass index ≥25...
January 10, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29319343/obesity-and-sudden-cardiac-death-in-the-young-clinical-and-pathological-insights-from-a-large-national-registry
#6
Gherardo Finocchiaro, Michael Papadakis, Harshil Dhutia, Della Cole, Elijah R Behr, Maite Tome, Sanjay Sharma, Mary N Sheppard
Aims Obesity is an increasing public health problem and a risk factor for cardiovascular diseases. The aim of the study was to determine the main features and aetiologies in a large cohort of sudden cardiac deaths that occurred in obese subjects. Methods Between 1994 and 2014, 3684 consecutive cases of unexpected sudden cardiac death were referred to our cardiac pathology centre. This study was confined to young individuals (age ≤ 35 years) for whom information about body mass index was available and consisted of 1033 cases...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29318960/the-role-of-inflammation-in-epicardial-adipose-tissue-in-heart-diseases
#7
Zdenek Matloch, Anna Cinkajzlova, Milos Mraze, Martin Haluzik
Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunocompetent cells, ganglia and interconnecting nerve branches. Several studies documented a positive correlation between pericardial and epicardial fat and left ventricular hypertrophy and septal thickening, leading to diastolic dysfunction, electrocardiographic abnormalities and facilitating cardiac failure...
January 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29313298/dimensions-of-and-responses-to-perceived-discrimination-and-subclinical-disease-among-african-americans-in-the-jackson-heart-study
#8
Victoria I Okhomina, LáShauntá Glover, Herman Taylor, Mario Sims
BACKGROUND: Although discrimination among African Americans (AAs) has been linked to various health outcomes, few studies have examined associations of multiple measures of discrimination with prevalent subclinical disease in a large sample of AAs. OBJECTIVES: To examine the associations of measures of discrimination and coping responses to discrimination with prevalent subclinical disease among AAs in the Jackson Heart Study (JHS); and whether this association is modified by sex...
January 8, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29313136/klotho-g-395a-gene-polymorphism-impact-on-progression-of-end-stage-renal-disease-and-development-of-cardiovascular-complications-in-children-on-dialysis
#9
Eman A Elghoroury, Fatina I Fadel, Manal F Elshamaa, Dina Kandil, Doaa M Salah, Marwa M El-Sonbaty, Hebatallah Farouk, Mona Raafat, Soha Nasr
BACKGROUND: Klotho G-395-A gene polymorphism may impact children with end-stage renal disease (ESRD). We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients. METHODS: Fifty-five children with chronic kidney disease (CKD) and seventy healthy children were genotyped for Klotho G-395A. RESULTS: Incidence of GA/AA genotypes and A allele were higher in ESRD patients compared with controls (54...
January 8, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29306449/chronic-exercise-induces-pathological-left-ventricular-hypertrophy-in-adrenaline-deficient-mice
#10
Priscila Mendes, Raquel Martinho, Sara Leite, Leonardo Maia-Moço, Adelino F Leite-Moreira, André P Lourenço, Mónica Moreira-Rodrigues
Adrenaline-deficient phenylethanolamine-N-methyltransferase-knockout mice (Pnmt-KO) have concentric heart remodeling and though their resting blood pressure is normal, it becomes higher during acute exercise. The aim of this study was to evaluate cardiac morphological, functional and molecular alterations after chronic exercise in adrenaline-deficient mice. Genotypes at the Pnmt locus were verified by polymerase chain reaction (PCR) of ear samples of Pnmt-KO and wild-type (WT) mice. These mice were submitted to chronic exercise training during 6weeks...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29302466/echocardiographic-and-electrocardiographic-abnormalities-in-adults-living-with-human-immunodeficiency-virus-a-cross-sectional-study-in-the-yaound%C3%A3-central-hospital-cameroon
#11
Ba Hamadou, Marie Ntep Ngweth, Miriam Megueo Fotso, Liliane Mfeukeu-Kuate, Ahmadou M Jingi, Jean Jacques Noubiap, Chris Nadege Nganou, Jerome Boombhi, Sylvie Ndongo Amougou, Alain Menanga, Samuel Kingue
Background: Cardiac involvement is frequent in the course of human immunodeficiency virus (HIV) infection disease. This work aimed at studying the profile of echocardiographic and electrocardiography (ECG) abnormalities in adults living with HIV (PLHIV), compared to those not infected with HIV at the treatment unit of the Yaoundé Central Hospital. Methods: We carried out a case-control study over three months at the HIV treatment unit. We included adults of both sexes, aged ≥21 years, HIV-infected (cases), and age and sex matched controls...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29301125/long-term-prognosis-after-myectomy-in-hypertrophic-obstructive-cardiomyopathy-with-severe-left-ventricular-hypertrophy
#12
Shuoyan An, Chaomei Fan, Yinjian Yang, Fei Hang, Zhimin Wang, Yuhui Zhang, Jian Zhang
OBJECTIVES: Patients with hypertrophic obstructive cardiomyopathy (HOCM) and severe left ventricular hypertrophy (maximal left ventricular wall thickness ≥30 mm) are at high risk of sudden cardiac death (SCD). In this study, we aimed to determine whether HOCM patients with severe hypertrophy had a lower incidence of SCD after myectomy. METHODS: HOCM patients with severe hypertrophy were consecutively enrolled from Fuwai Hospital in China between 2000 and 2013...
January 5, 2018: Cardiology
https://www.readbyqxmd.com/read/29290461/oculomotor-palsy-in-diabetics
#13
H Lajmi, W Hmaied, W Ben Jalel, Z Chelly, A Ben Yakhlef, F Ben Zineb, L El Fekih
INTRODUCTION: Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications of diabetic patients. It generates less interest in the literature than the other ocular manifestations. Our goal was to study the clinical, epidemiological, therapeutic and prognostic characteristics of oculomotor palsy in the diabetic. METHODS: This is a retrospective study of 24 diabetic patients with oculomotor palsy. The ophthalmological examination emphasized ocular motility...
December 28, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29290033/effects-of-obesity-and-metabolic-syndrome-on-cardiovascular-outcomes-in-pediatric-kidney-transplant-recipients-a-longitudinal-study
#14
Kristen Sgambat, Sarah Clauss, K Y Lei, Juizhou Song, Shaik O Rahaman, Margaret Lasota, Asha Moudgil
BACKGROUND: Obesity and metabolic syndrome (MS) are common after kidney transplantation, but their contribution to adverse cardiovascular (CV) outcomes in children are not well known. A prospective, controlled, longitudinal cohort study was conducted to investigate the effects of obesity and MS on left ventricular hypertrophy (LVH) and myocardial strain in pediatric kidney transplant recipients. METHODS: Transplant recipients (n = 42) had anthropometrics [body mass index (BMI), waist circumference, waist-to-height ratio], biochemical parameters (fasting glucose, lipid panel, HbA1c%), and echocardiogram with speckle tracking analysis for strain measured at 1, 18, and 30 months post-transplant...
December 30, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29286514/cardiovascular-diseases-and-systolic-function-of-left-ventricle-in-clean-up-workers-of-chernobyl-accident-based-on-30-years-follow-up
#15
O D Bazyka, D O Belyi
OBJECTIVE: To study the dynamics of circulatory system diseases during the 30 year period after irradiation, changes in the status of systolic function of heart left ventricle (LV) and the features of its remodeling in clean up workers (CW) of the accident at the Chernobyl nuclear power plant (ChNPP). MATERIAL AND METHODS: It was examined 144 CW at ChNPP, including 52 patients, who survived acute radiation sick ness (ARS) grade of severity 1-3, and 105 non irradiated persons (control group - CG)...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29286269/landmark-lecture-perloff-lecture-tribute-to-professor-joseph-kayle-perloff-and-lessons-learned-from-him-aortopathy-in-adults-with-chd
#16
Koichiro Niwa
Marfan syndrome, bicuspid aortic valve, and/or coarctation of the aorta are associated with medial abnormalities of the ascending aortic or para-coarctation aorta. Medial abnormalities in the ascending aorta are prevalent in other type of patients with a variety of CHDs such as single ventricle, persistent truncus arteriosus, transposition of the great arteries, hypoplastic left heart syndrome, and tetralogy of Fallot, encompassing a wide age range and may predispose to dilatation, aneurysm, and rapture necessitating aortic valve and root surgery...
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29284499/left-atrial-structure-and-function-in-hypertrophic-cardiomyopathy-sarcomere-mutation-carriers-with-and-without-left-ventricular-hypertrophy
#17
Hoshang Farhad, Sara B Seidelmann, Davis Vigneault, Siddique A Abbasi, Eunice Yang, Sharlene M Day, Steven D Colan, Mark W Russell, Jeffrey Towbin, Mark V Sherrid, Charles E Canter, Ling Shi, Michael Jerosch-Herold, David A Bluemke, Carolyn Ho, Tomas G Neilan
BACKGROUND: Impaired left atrial (LA) function is an early marker of cardiac dysfunction and predictor of adverse cardiac events. Herein, we assess LA structure and function in hypertrophy in hypertrophic cardiomyopathy (HCM) sarcomere mutation carriers with and without left ventricular hypertrophy (LVH). METHOD: Seventy-three participants of the HCMNet study who underwent cardiovascular magnetic resonance (CMR) imaging were studied, including mutation carriers with overt HCM (n = 34), preclinical mutation carriers without HCM (n = 24) and healthy, familial controls (n = 15)...
December 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29283224/autonomic-regulation-therapy-to-enhance-myocardial-function-in-heart-failure-patients-the-anthem-hfpef-study
#18
Lorenzo A DiCarlo, Imad Libbus, H Uday Kumar, Sanjay Mittal, Rajendra K Premchand, Badri Amurthur, Bruce H KenKnight, Jeffrey L Ardell, Inder S Anand
BACKGROUND: Approximately half of the patients presenting with new-onset heart failure (HF) have HF with preserved left ventricular ejection fraction (HFpEF) and HF with mid-range left ventricular ejection fraction (HFmrEF). These patients have neurohormonal activation like that of HF with reduced ejection fraction; however, beta-blockers and angiotensin-converting enzyme inhibitors have not been shown to improve their outcomes, and current treatment for these patients is symptom based and empiric...
December 28, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29280914/anemia-and-coronary-artery-disease-pathophysiology-prognosis-and-treatment
#19
Jennifer A Rymer, Sunil V Rao
The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state persists chronically. We will examine the evidence for anemia as an independent risk factor for CAD events and cardiovascular mortality after percutaneous coronary intervention. We will also investigate the thresholds for appropriate blood transfusion in patients with CAD, as well as the cardiovascular outcomes associated with the utilization of a liberal versus conservative blood transfusion strategy...
December 26, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29280520/significance-of-isolated-papillary-muscle-hypertrophy-a-comparison-of-left-ventricular-hypertrophy-diagnosed-using-electrocardiography-vs-echocardiography
#20
Namiko Nomura, Tomoko Tani, Toshiko Konda, Kitae Kim, Takeshi Kitai, Natsumi Nomoto, Naoko Suganuma, Hitomi Nakamura, Toshiaki Sumida, Yoko Fujii, Junichi Kawai, Shuichiro Kaji, Yutaka Furukawa
AIMS: The clinical significance of papillary muscle hypertrophy and its electrocardiography (ECG) findings has not been fully elucidated. This study aimed to investigate the relationship between ECG findings and papillary muscle hypertrophy and to confirm the importance of papillary muscle measurements on transthoracic echocardiography (TTE). METHODS AND RESULTS: Of the 237 consecutive patients who showed left ventricular hypertrophy (LVH) pattern on a 12-lead ECG, TTE data were available for 101 patients...
December 27, 2017: Echocardiography
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