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https://www.readbyqxmd.com/read/28741295/early-segmental-relaxation-abnormalities-in-hypertrophic-cardiomyopathy-for-differential-diagnostic-of-patients-with-left-ventricular-hypertrophy
#1
Christian Voigt, Julia Münch, Maxim Avanesov, Anna Suling, Katrin Witzel, Gunnar Lund, Monica Patten
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy (LVH). However, clinical signs can be subtle and differentiation from other causes of LVH is challenging. HYPOTHESIS: As diastolic dysfunction (DD) is an early sign in HCM, we aimed to find regional changes in relaxation pattern for differentiation from other entities of LVH. METHODS: In 148 patients (81 HCM, 55 arterial hypertension (AHT), 12 Fabry disease) and 63 healthy controls, relaxation patterns were assessed using regional tissue Doppler imaging...
July 24, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28740581/the-parathyroid-gland-and-heart-disease
#2
Spandana J Brown, Mary D Ruppe, Laila S Tabatabai
The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Patients with disorders of the parathyroid gland have higher incidences of hypertension, arrhythmias, left ventricular hypertrophy, heart failure, and calcific disease which translate into increased cardiac morbidity and mortality...
April 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28738426/long-term-effects-of-liraglutide-in-japanese-patients-with-type-2-diabetes-among-the-subgroups-with-different-renal-functions-results-of-2-year-prospective-study
#3
Takeyuki Hiramatsu, Akiko Ozeki, Hideaki Ishikawa, Shinji Furuta
Aims Very few studies have ever examined the effects of long-term (>1 year) administration of liraglutide in patients with type 2 diabetes mellitus (T2DM) and renal impairment. Therefore, we conducted a 2-year study to prospectively examine the effects of liraglutide in those patients. Methods A total of 148 patients with T2DM were enrolled and treated with liraglutide (0.6 or 0.9 mg/day). 97 patients completed the 2-year study without protocol deviations. These patients were divided into 3 groups according to the baseline estimated glomerular filtration ratio (eGFR) (in mL/min/1...
July 24, 2017: Drug Research
https://www.readbyqxmd.com/read/28736560/nonparallel-progression-of-left-ventricular-structure-and-function-in-long-term-peritoneal-dialysis-patients
#4
Qiuhong Shi, Jing Zhu, Sheng Feng, Huaying Shen, Jianchang Chen, Kai Song
BACKGROUND/AIMS: Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose of this study was to investigate the dynamic changes of left ventricular (LV) structure and function in patients on long-term PD. METHODS: Patients who underwent PD catheter insertions from January 2010 to December 2012 in our PD center were enrolled into this study. Cardiac structure and function of those patients were determined by echocardiography (4 times) at 12-month intervals...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28735292/pathogenesis-of-hypertrophic-cardiomyopathy-is-mutation-rather-than-disease-specific-a-comparison-of-the-cardiac-troponin-t-e163r-and-r92q-mouse-models
#5
Cecilia Ferrantini, Raffaele Coppini, Josè Manuel Pioner, Francesca Gentile, Benedetta Tosi, Luca Mazzoni, Beatrice Scellini, Nicoletta Piroddi, Annunziatina Laurino, Lorenzo Santini, Valentina Spinelli, Leonardo Sacconi, Pieter De Tombe, Rachel Moore, Jil Tardiff, Alessandro Mugelli, Iacopo Olivotto, Elisabetta Cerbai, Chiara Tesi, Corrado Poggesi
BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation-driven changes in myofilament function combined with excitation-contraction (E-C) coupling abnormalities related to adverse remodeling. Whether myofilament or E-C coupling alterations are more relevant in disease development is unknown. Here, we aim to investigate whether the relative roles of myofilament dysfunction and E-C coupling remodeling in determining the hypertrophic cardiomyopathy phenotype are mutation specific...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28734917/lvh-and-cad-new-steps-down-an-old-path
#6
EDITORIAL
Nathaniel Reichek
No abstract text is available yet for this article.
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28733446/how-does-pressure-overload-cause-cardiac-hypertrophy-and-dysfunction-high-ouabain-affinity-cardiac-na-pumps-are-crucial
#7
Mordecai P Blaustein
Left ventricular hypertrophy is frequently observed in hypertensive patients, and is believed to be due to the pressure overload and cardiomyocyte stretch. Three recent reports on mice with genetically-engineered Na(+) pumps, however, demonstrate that cardiac ouabain-sensitive α2 Na(+) pumps play a key role in the pathogenesis of trans-aortic constriction (TAC)-induced hypertrophy. Hypertrophy was delayed/attenuated in mice with mutant, ouabain-resistant α2 Na(+) pumps and in mice with cardiac-selective knockout (KO) or transgenic overexpression (TG) of α2 Na(+) pumps...
July 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28731929/impact-of-aortic-rather-than-brachial-pulsatile-haemodynamics-on-variations-in-end-organ-measures-across-the-full-adult-blood-pressure-range
#8
Bryan Hodson, Gavin R Norton, Imraan Ballim, Carlos D Libhaber, Pinhas Sareli, Angela J Woodiwiss
AIMS: To determine the extent to which the adverse effects of blood pressure (BP) are mediated by pulsatile haemodynamic changes across the normotensive as compared with the hypertensive adult brachial BP range, and whether aortic rather than brachial pulsatile changes best index these effects. METHODS: In 1307 community participants, the contribution of pulsatile haemodynamics (applanation tonometry and SphygmoCor software) to variations in left ventricular mass index (LVMI) (echocardiography) (n = 920), carotid intima-media thickness (IMT) (n = 712) and estimated glomerular filtration rate (eGFR) (n = 1164) were assessed...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28730800/optimizing-the-role-of-transthoracic-echocardiography-to-improve-the-cardiovascular-risk-stratification-the-dream-of-subclinical-coronary-artery-disease-detection
#9
Giovanni Benfari, Andrea Rossi, Giulia Geremia, Giulia Vinco, Carlo Zivelonghi, Aldo D Milano, Leonardo Gottin, Flavio L Ribichini, Francesco Onorati, Giuseppe Faggian
Detecting coronary artery disease at a subclinical level has always been a challenging task for cardiologists. Various non-invasive echocardiographic approaches such as measurements of left ventricular hypertrophy, diastolic function, left atrial enlargement, valve sclerosis and calcification, epicardial fat thickness, and pulse wave velocity have been proposed to integrate the available risk-charts. The present review is a collection of evidence that supports the role of the above mentioned features in cardiac risk stratification, summarizing the state of the art in non-invasive echocardiographic coronary risk assessment...
July 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28728692/magnetic-resonance-in-transthyretin%C3%A2-cardiac-amyloidosis
#10
Ana Martinez-Naharro, Thomas A Treibel, Amna Abdel-Gadir, Heerajnarain Bulluck, Giulia Zumbo, Daniel S Knight, Tushar Kotecha, Rohin Francis, David F Hutt, Tamer Rezk, Stefania Rosmini, Candida C Quarta, Carol J Whelan, Peter Kellman, Julian D Gillmore, James C Moon, Philip N Hawkins, Marianna Fontana
BACKGROUND: Cardiac transthyretin amyloidosis (ATTR) is an increasingly recognized cause of heart failure. Cardiac magnetic resonance (CMR), with late gadolinium enhancement (LGE) and T1 mapping, is emerging as a reference standard for diagnosis and characterization of cardiac amyloidosis. OBJECTIVES: The authors used CMR with extracellular volume fraction (ECV) measurement to characterize cardiac involvement in relation to outcome in ATTR. METHODS: Subjects comprised 263 patients with cardiac ATTR corroborated by grade 2 to 3 (99m)Tc-DPD ((99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) cardiac uptake, 17 with suspected cardiac ATTR (grade 1 (99m)Tc-DPD), and 12 asymptomatic individuals with amyloidogenic transthyretin (TTR) mutations...
July 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28728485/factors-associated-with-global-longitudinal-strain-decline-in-hypertensive-patients-with-normal-left-ventricular-ejection-fraction
#11
Nabila Soufi Taleb Bendiab, Abderrahim Meziane-Tani, Souhila Ouabdesselam, Nadera Methia, Samia Latreche, Latefa Henaoui, Jean-Jacques Monsuez, Salim Benkhedda
Background Early detection of risk factors for left ventricular (LV) dysfunction may be useful in patients with high blood pressure (HBP). Methods Patient from an outpatient HBP clinic underwent a two-dimensional Doppler-coupled echocardiography with determination of LV global longitudinal strain (GLS) by speckle-tracking. Results Among 200 patients (mean age 61.7 ± 9.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP. LV hypertrophy (LVH) was found in 136 patients (68%), including concentric ( n = 106) and eccentric ( n = 30) LVH...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28723880/prevalence-and-clinical-characteristics-of-white-coat-hypertension-based-on-different-definition-criteria-in-untreated-and-treated-patients
#12
Alejandro de la Sierra, Ernest Vinyoles, José R Banegas, Julián Segura, Manuel Gorostidi, Juan J de la Cruz, Luis M Ruilope
BACKGROUND AND AIM: The prevalence and associated risks of white-coat hypertension (WCH) are still a matter of debate. We aimed to assess differences in prevalence and associated conditions of WCH defined on the basis of the normality of all daytime, night-time, and 24-h blood pressure (BP), only daytime, or only 24-h BP. METHODS: We selected 115 708 patients (45 020 untreated and 70 688 treated) from the Spanish Ambulatory BP Monitoring Registry. WCH was estimated in patients with elevated office BP (≥140 and/or 90 mmHg) by using normal daytime (<135/85) BP, normal 24-h BP (<130/80), or normal daytime, night-time (<120/70) and 24-h BP...
July 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28722487/left-ventricular-hypertrophy-in-acute-stroke-patients-with-known-hypertension
#13
Askiel Bruno, Desiree D Brooks, Taryn A Abrams, Mitra D Poorak, Drew Gunio, Prianka K Kandhal, Aleena Lakhanpal, Arun K Nagabandi, Abiodun E Akinwuntan, Stephen Looney, Pascha E Schafer
BACKGROUND: Despite effective treatments, hypertension remains uncontrolled in nearly half of the people with hypertension in the United States. Uncontrolled hypertension leads to end organ damage, such as left ventricular hypertrophy (LVH). To identify reasons for uncontrolled hypertension, we interviewed acute stroke patients with a history of hypertension and evaluated for LVH. METHODS: Using a standardized questionnaire, we collected demographic, socioeconomic, and health-care data in 300 acute ischemic and hemorrhagic stroke patients in one hospital...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28721696/usefulness-of-fragmented-qrs-in-hypertensive-patients-in-the-absence-of-left-ventricular-hypertrophy
#14
Mehmet Eyuboglu, Yavuz Karabag, Suleyman Karakoyun, Omer Senarslan, Zulkif Tanriverdi, Bahri Akdeniz
In the absence of left ventricular hypertrophy, importance of fragmented QRS complex (fQRS) in individuals with hypertension is unknown. The authors aimed to evaluate the relationship between blood pressure levels and fQRS in the absence of left ventricular hypertrophy. A total of 548 never-treated patients who underwent 24-hour ambulatory blood pressure monitoring were enrolled. The frequency of fQRS was significantly higher in patients with hypertension than normotension (36.4% vs 17.6%, P<.05). Multivariate logistic regression analysis revealed that systolic blood pressure is significantly associated with presence of fQRS on electrocardiography (odds ratio, 0...
July 18, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28717668/different-renal-phenotypes-in-related-adult-males-with-fabry-disease-with-the-same-classic-genotype
#15
Renzo Mignani, Mariarita Moschella, Giovanna Cenacchi, Ilaria Donati, Marta Flachi, Daniela Grimaldi, Davide Cerretani, Paola De Giovanni, Marcello Montevecchi, Angelo Rigotti, Alessandro Ravasio
BACKGROUND: Fabry disease related patients with classical mutation usually exhibit similar severe phenotype especially concerning renal manifestation. METHODS: A dry blood spot screening (DBS) and the DNA analysis has been performed in a 48-year-old man (Patient 1) because of paresthesia. RESULTS: The DBS revealed absent leukocyte α-Gal A enzyme activity while DNA analysis identified the I354K mutation. Serum creatinine and e-GFR were in normal range and also albuminuria and proteinuria were absent...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28714523/echocardiographic-parameters-versus-cha2ds2-vasc-score-in-prediction-of-overall-cardiac-events-heart-failure-and-stroke-in-non-valvular-atrial-fibrillation
#16
Li-Tan Yang, Wei-Chuan Tsai, Ho-Ming Su
BACKGROUND: Apart from stroke, atrial fibrillation (AF) is associated with higher mortality and heart failure (HF), in which risk stratification scheme is lacking. Therefore this investigation examined the prognostic value of echocardiographic predictors against CHA₂DS₂-VASc score in permanent non-valvular AF (NVAF). METHOD: In 252 asymptomatic or mildly symptomatic consecutive patients with NVAF, comprehensive echocardiography was performed. Left atrial deformation parameters were also obtained by two-dimensional speckle tracking echocardiography...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28713836/increased-serum-uric-acid-level-is-a-risk-factor-for-left-ventricular-hypertrophy-but-not-independent-of-egfr-in-patients-with-type-2-diabetic-kidney-disease
#17
Chuchu Zeng, Dongsheng Cheng, Xiaohua Sheng, Guihua Jian, Ying Fan, Yuqiang Chen, Junhui Li, Hongda Bao, Niansong Wang
BACKGROUND: Although the relation between serum uric acid (SUA) and left ventricular hypertrophy (LVH) has been studied for decades, however, their association remains debatable. METHODS: This is a retrospective study in which a total of 435 hospitalized Chinese patients with type 2 DKD were enrolled. The subjects were stratified into quartiles according to SUA level. LVH was assessed by two-dimensional guided M-mode echocardiography. RESULTS: There was a significant increase in the prevalence of LVH in patients with type 2 DKD across SUA quartiles (28...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28712176/ecg-abnormalities-in-patients-with-chronic-kidney-disease
#18
Salman Shafi, Mohammad Saleem, Roshina Anjum, Wajid Abdullah, Tahir Shafi
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease. Electrocardiographic (ECG) abnormalities are common in CKD patients. However, there is variation in literature regarding frequency of ECG abnormalities in CKD patients and limited information in local population. METHODS: The study design was cross-sectional in nature. All patients between ages of 20-80 years with CKD not previously on renal replacement therapy who were admitted to nephrology ward at a tertiary care facility over a 6-month period were included...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711960/chronic-kidney-disease-ckd-an-observational-study-of-etiology-severity-and-burden-of-comorbidities
#19
Nivedita Kamath, Arpana Aprameya Iyengar
OBJECTIVES: To study the etiology and burden of comorbidities across stages of chronic kidney disease (CKD). METHODS: Children, 2-16 y of age with CKD Stages II- IV were recruited over 12 mo. The etiology, clinical presentation and severity of complications were studied. RESULTS: Among 78 children [Stage II (n = 21), Stage III (n = 26), Stage IV (n = 31)], congenital anomalies of the kidney and urinary tract (CAKUT) was the commonest etiology and 28 were newly diagnosed in Stage III /IV...
July 15, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28705548/age-dependent-ventricular-arrhythmias-risk-structural-and-molecular-remodeling-in-systemic-arterial-hypertension
#20
Alina Scridon, Rosa Doñate Puertas, Waheed Manati, Emmanuelle Fouilloux-Meugnier, Emmanuelle Loizon, Valérie Oréa, Bruno Chapuis, Claude Julien, Christian Barrès, Alain Tabib, Philippe Chevalier
INTRODUCTION: The left ventricular hypertrophy (LVH)-ventricular arrhythmias relationship associated with arterial hypertension and aging remains controversial. We aimed to assess the age-dependency of ventricular arrhythmias in spontaneously hypertensive rats (SHRs) and the corresponding ventricular structural and molecular remodeling. MATERIALS AND METHODS: Ventricular arrhythmias were quantified using 24-h radiotelemetry ECG monitoring in eight SHRs and four Wistar-Kyoto (WKY) rats at 14 (young), 24 (adult), and 48 (aging) weeks of age...
July 10, 2017: Mechanisms of Ageing and Development
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