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Beatriz Bermudez, Tuva Borresdatter Dahl, Indira Medina, Mathijs Groeneweg, Sverre Holm, Sergio Montserrat-de la Paz, Mat Rousch, Jeroen Otten, Veronica Herias, Lourdes M Varela, Trine Ranheim, Arne Yndestad, Almudena Ortega-Gomez, Rocio Abia, Laszlo Nagy, Pal Aukrust, Francisco J G Muriana, Bente Halvorsen, Erik Anna Leonardus Biessen
OBJECTIVE: Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), the rate limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD)(+) generation, in atherogenesis is largely unknown. Here we investigated the effects of iNAMPT overexpression in leukocytes on inflammation and atherosclerosis. APPROACH AND RESULTS: Low-density lipoprotein receptor-deficient mice with hematopoietic overexpression of human iNAMPT (iNAMPT(hi)), on a western type diet, showed attenuated plaque burden with features of lesion stabilization...
June 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
Indira Medina, Céline Cougoule, Maik Drechsler, Beatriz Bermudez, Rory R Koenen, Judith Sluimer, Ine Wolfs, Yvonne Döring, Veronica Herias, Marjon Gijbels, Ilze Bot, Saskia de Jager, Christian Weber, Jack Cleutjens, Theo J C van Berkel, Kees-Jan Sikkink, Atilla Mócsai, Isabelle Maridonneau-Parini, Oliver Soehnlein, Erik A L Biessen
BACKGROUND: Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated. METHODS AND RESULTS: Hematopoietic Hck/Fgr-deficient, LDLr(-/-) chimeras, obtained by bone marrow transplantation, had smaller but, paradoxically, less stable lesions with reduced macrophage content, overt cap thinning, and necrotic core expansion as the most prominent features...
August 11, 2015: Circulation
Veronica Herías, Erik A L Biessen, Cora Beckers, Dianne Delsing, Mengyang Liao, Mat J Daemen, Christine C T N Pham, Sylvia Heeneman
OBJECTIVE: The protein degrading activity of cathepsin C (CatC), combined with its role in leukocyte granule activation, suggests a contribution of this cystein protease in atherosclerosis. However, no experimental data are available to validate this concept. APPROACH AND RESULTS: CatC gene and protein expression were increased in ruptured versus advanced stable human carotid artery lesions. To assess causal involvement of CatC in plaque progression and stability, we generated LDLr(-/-)//CatC(-/-) chimeras by bone marrow transplantation...
January 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
Ilze Bot, Isabelle T M N Daissormont, Alma Zernecke, Gijs H M van Puijvelde, Birgit Kramp, Saskia C A de Jager, Judith C Sluimer, Marco Manca, Veronica Hérias, Marijke M Westra, Martine Bot, Peter J van Santbrink, Theo J C van Berkel, Lishan Su, Mona Skjelland, Lars Gullestad, Johan Kuiper, Bente Halvorsen, Paul Aukrust, Rory R Koenen, Christian Weber, Erik A L Biessen
AIMS: The SDF-1α/CXCR4 dyad was previously shown by us and others to be instrumental in intimal hyperplasia as well as early stage atherosclerosis. We here sought to investigate its impact on clinically relevant stages of atherosclerosis in mouse and man. METHODS AND RESULTS: Immunohistochemical analysis of CXCR4 expression in human atherosclerotic lesions revealed a progressive accumulation of CXCR4(+) cells during plaque progression. To address causal involvement of CXCR4 in advanced stages of atherosclerosis we reconstituted LDLr(-/-) mice with autologous bone marrow infected with lentivirus encoding SDF-1α antagonist or CXCR4 degrakine, which effects proteasomal degradation of CXCR4...
September 2014: Journal of Molecular and Cellular Cardiology
Joost J Leenders, Wino J Wijnen, Monika Hiller, Ingeborg van der Made, Viola Lentink, Rick E W van Leeuwen, Veronica Herias, Saraswati Pokharel, Stephane Heymans, Leon J de Windt, Morten A Høydal, Yigal M Pinto, Esther E Creemers
Pathological forms of left ventricular hypertrophy (LVH) often progress to heart failure. Specific transcription factors have been identified that activate the gene program to induce pathological forms of LVH. It is likely that apart from activating transcriptional inducers of LVH, constitutive transcriptional repressors need to be removed during the development of cardiac hypertrophy. Here, we report that the constitutive presence of Krüppel-like factor 15 (KLF15) is lost in pathological hypertrophy and that this loss precedes progression toward heart failure...
August 27, 2010: Journal of Biological Chemistry
Lili Bai, Linda Beckers, Erwin Wijnands, Suzanne P M Lutgens, M Verónica Herías, Paul Saftig, Mat J A P Daemen, Kitty Cleutjens, Esther Lutgens, Erik A L Biessen, Sylvia Heeneman
Cathepsin K (catK), a lysosomal cysteine protease, exerts strong elastinolytic and collagenolytic activity and is implicated in a range of pathological disorders including cardiovascular disease. CatK expression was found to be elevated in human aortic aneurysm pointing to a role in this vasculopathy. In the angiotensin II (Ang II)-induced mouse model for aneurysm formation, catK, S and C expression was strongly upregulated. Therefore, we investigated the effect of catK deficiency on Ang II-induced aneurysm formation in the abdominal aorta of apoE-/- mice...
March 2010: Atherosclerosis
Robbert-Jan J H M Miserus, M Veronica Herías, Lenneke Prinzen, Marc B I Lobbes, Robert-Jan Van Suylen, Anouk Dirksen, Tilman M Hackeng, Johan W M Heemskerk, Jos M A van Engelshoven, Mat J A P Daemen, Marc A M J van Zandvoort, Sylvia Heeneman, Marianne Eline Kooi
OBJECTIVES: We aimed to investigate whether early thrombus formation can be visualized with in vivo magnetic resonance imaging (MRI) by the use of a novel bimodal alpha(2)-antiplasmin-based contrast agent (CA). BACKGROUND: Thrombus formation plays a central role in several vascular diseases. During the early phases of thrombus formation, activated factor XIII (FXIIIa) covalently cross-links alpha(2)-antiplasmin to fibrin, indicating the potential of alpha(2)-antiplasmin-based CAs in the detection of early thrombus formation...
August 2009: JACC. Cardiovascular Imaging
Robert A Matthijsen, Menno P J de Winther, Dian Kuipers, Ingeborg van der Made, Christian Weber, M Veronica Herias, Marion J J Gijbels, Wim A Buurman
BACKGROUND: With consideration of the central role of the innate immune system in atherogenesis and mannose-binding lectin (MBL) as an innate regulator of immunity, the role of MBL in experimental and human atherosclerosis was assessed. METHODS AND RESULTS: With the use of immunohistochemistry and polymerase chain reaction, deposition and gene expression of MBL-A and -C were assessed in murine atherosclerosis from mice deficient for the low-density lipoprotein receptor (LDLR(-/-)) after 10 or 18 weeks of high-fat feeding...
April 28, 2009: Circulation
Rudy F Duisters, Anke J Tijsen, Blanche Schroen, Joost J Leenders, Viola Lentink, Ingeborg van der Made, Veronica Herias, Rick E van Leeuwen, Mark W Schellings, Paul Barenbrug, Jos G Maessen, Stephane Heymans, Yigal M Pinto, Esther E Creemers
The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an attractive therapeutic target. Regulation of CTGF expression at the promoter level has been studied extensively, but it is unknown how CTGF transcripts are regulated at the posttranscriptional level...
January 30, 2009: Circulation Research
Astrid Hogenkamp, M Veronica Herías, Peter C J Tooten, Edwin J A Veldhuizen, Henk P Haagsman
Surfactant protein D (SP-D) interacts with various different microorganisms and plays an important role in pulmonary innate immunity. SP-D expression has also been detected in extrapulmonary tissues, including the gastro-intestinal tract. However, its function in the intestine is unknown and may differ considerably from SP-D functions in the lung. Therefore, the effects of porcine SP-D (pSP-D) on several strains of intestinal bacteria were studied by means of bacterial growth assays, colony-count assays, radial diffusion assays and differential fluorescent staining...
July 2007: Molecular Immunology
M Veronica Herías, Astrid Hogenkamp, Alphons J A M van Asten, Monique H G Tersteeg, Martin van Eijk, Henk P Haagsman
Surfactant proteins A and D are pattern recognition molecules that play a role in pulmonary host defence. In this paper, we describe for the first time the expression and localisation of both collectins in various porcine tissues using a combination of in situ hybridisation (ISH), RT-PCR and immunohistochemistry (IHC). SP-D was expressed in several tissues including lung, tongue, intestinal tract, thymus, skin, gall bladder and lacrimal gland. Focal SP-D expression was detected in oesophagus, stomach, kidney, liver, prostate and spleen with both histological techniques...
July 2007: Molecular Immunology
Davy Vanhoutte, Mark W M Schellings, Martin Götte, Melissa Swinnen, Veronica Herias, Martin K Wild, Dietmar Vestweber, Emmanuel Chorianopoulos, Víctor Cortés, Attilio Rigotti, Mary-Ann Stepp, Frans Van de Werf, Peter Carmeliet, Yigal M Pinto, Stephane Heymans
BACKGROUND: The cell-associated proteoglycan syndecan-1 (Synd1) closely regulates inflammation and cell-matrix interactions during wound healing and tumorigenesis. The present study investigated whether Synd1 may also regulate cardiac inflammation, matrix remodeling, and function after myocardial infarction (MI). METHODS AND RESULTS: First, we showed increased protein and mRNA expression of Synd1 from 24 hours on, reaching its maximum at 7 days after MI and declining thereafter...
January 30, 2007: Circulation
M V Herías, J F J G Koninkx, J G Vos, J H J Huis in't Veld, J E van Dijk
We tested the effect of Lactobacillus casei strain Shirota (LcS) on the murine model of ulcerative colitis induced by dextran sodium sulphate. The effect of LcS was tested either as a prophylactic 10 days before the onset of the disease, simultaneously with ulcerative colitis induction or continued 10 days after the disease was induced. LcS was not able to prevent the disease induction in any of the experiments. However, important clinical parameters including blood anemia indicators, body weight, and organ weight were improved in the animals receiving LcS as compared with the ulcerative colitis-induced controls...
August 25, 2005: International Journal of Food Microbiology
H P Haagsman, V Herias, M van Eijk
No abstract text is available yet for this article.
December 2003: Acta Pharmacologica Sinica
No abstract text is available yet for this article.
August 3, 1962: Prensa Médica Argentina
No abstract text is available yet for this article.
January 1953: Pediatria de las Américas
V M Herías, A K Robertson, T Midtvedt, A E Wold
Escherichia coli S fimbriae, which bind to sialic acid residues, are a virulence factor for extraintestinal infection, but also promote binding to intestinal epithelial cells. In this study, we investigated whether S fimbriae would enhance intestinal colonization by E. coli or promote translocation to extraintestinal sites. A mixture of two E. coli isogenic strains both expressing type-1 fimbriae but differing in the carriage of S fimbriae (Sfim+ and Sfim-) were given perorally to germfree neonatal, infant or adult rats...
August 2001: Microbial Pathogenesis
M V Herías, C Hessle, E Telemo, T Midtvedt, L A Hanson, A E Wold
We have studied the effect of the probiotic strain Lactobacillus plantarum 299v on the immune functions of gnotobiotic rats. One group of germ-free rats was colonized with the type 1-fimbriated Escherichia coli O6:K13:H1 and another group with the same E. coli strain together with L. plantarum 299v. One and 5 weeks after colonization, bacterial numbers were determined in the contents of the small intestine, caecum and mesenteric lymph nodes. Small intestinal sections were examined for CD8+, CD4+, CD25+ (IL-2R alpha-chain), IgA+ and MHC class II+ cells and mitogen-induced spleen cell proliferation was determined...
May 1999: Clinical and Experimental Immunology
M V Herías, T Midtvedt, L A Hanson, A E Wold
Germ-free rats were colonized with E. coli alone, or with E. coli plus Lactobacillus acidophilus and a strain of the obligate anaerobic gram-positive species, Peptostreptococcus. The presence of Peptostreptococcus reduced translocation of E. coli, but increased the serum antibody response to E. coli antigen. Whereas the immunoglobulin G (IgG) anti-E. coli antibodies largely represented cross-reactive antibodies, those of the immunoglobulin M (IgM) isotype represented true anti-E. coli antibodies because they could not be absorbed by L...
September 1998: Scandinavian Journal of Immunology
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