Indira Medina, Céline Cougoule, Maik Drechsler, Beatriz Bermudez, Rory R Koenen, Judith Sluimer, Ine Wolfs, Yvonne Döring, Veronica Herias, Marjon Gijbels, Ilze Bot, Saskia de Jager, Christian Weber, Jack Cleutjens, Theo J C van Berkel, Kees-Jan Sikkink, Atilla Mócsai, Isabelle Maridonneau-Parini, Oliver Soehnlein, Erik A L Biessen
BACKGROUND: Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated. METHODS AND RESULTS: Hematopoietic Hck/Fgr-deficient, LDLr(-/-) chimeras, obtained by bone marrow transplantation, had smaller but, paradoxically, less stable lesions with reduced macrophage content, overt cap thinning, and necrotic core expansion as the most prominent features...
August 11, 2015: Circulation