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Salivary glands radiotherapy

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https://www.readbyqxmd.com/read/29329558/quality-of-life-and-problems-associated-with-obturators-of-patients-with-maxillectomies
#1
Marwa Mohammed Ali, Nadia Khalifa, Mohammed Nasser Alhajj
BACKGROUND: Maxillary defects predispose patients to different undesirable effects. The aim of this study was to assess the quality of life (QoL) of patients with maxillary defects (acquired/congenital) wearing obturators. METHODS: The study comprised 30 patients aged between 16 and 78 years. Interviews were conducted to collect information pertaining to patients; sociodemographic, self-reported function of obturator using Obturator Functioning Scale (OFS), self-evaluation of general health using Visual Analogue Scale (VAS), radiotherapy treatment, salivary gland removal, reconstructive surgery, neck dissection and length of time obturators were worn...
January 5, 2018: Head & Face Medicine
https://www.readbyqxmd.com/read/29313462/mucoepidermoid-carcinoma-a-23-year-experience-with-emphasis-on-low-grade-tumors-with-close-positive-margins
#2
Joseph Spellman, Gabriel Calzada
Objective Describe outcomes for mucoepidermoid carcinoma by histologic grade and evaluate outcomes for patients with low-grade tumors with close/positive margins after initial surgical resection. Study Design Cohort study. Setting Kaiser Permanente Southern California Medical Group from 1993 to 2016. Subjects and Methods Retrospective review of 154 patients with major and minor salivary gland mucoepidermoid carcinoma of the head and neck. Disease-specific and recurrence-free survival were stratified by tumor grade...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29290320/-sarcomatoid-carcinoma-of-larynx-a-histological-challenge
#3
Alejandra Osorio-Velásquez, Carlos M Chiesa-Estomba, Frank A Betances-Reinoso, M Pilar San Miguel-Fraile, José A Ortiz-Rey
INTRODUCTION: Sarcomatoid carcinoma can occur in any part of the body; in the head and neck it occurs most frequently in the major salivary glands, with only about 1% of cases found in the larynx. As it has both epithelial and mesenchymal components, there are many theories concerning its origin and it can prove a diagnostic challenge. CASE REPORT: A 76 year old male smoker presented with dysphonia. Vocal cord injury was found on examination but no lymphadenopathy or metastases were present...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29250681/acinic-cell-carcinoma-of-minor-salivary-glands-case-report
#4
Camelia Liana Buhaş, Elena Roşca, Gabriela MuŢiu, Alina Cristiana Venter, Bogdan Adrian Buhaş, Răzvan CouŢi, Camelia Florentina Ciobanu, Dragoş Mircea Roşca
Salivary gland tumors have a high incidence (90%) within the parotid gland. The acinic cell carcinoma (ACC) represents only 1-3% of the salivary gland tumors, most frequently affecting the parotid. The minor salivary glands rarely develop ACC and when the ACC is localized in these glands, generally, it has a less aggressive evolution. The main criterion in the diagnostic of ACC is the histological examination with the regular Hematoxylin-Eosin (HE) staining and additionally Periodic Acid-Schiff (PAS) special staining...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29248424/hyperbaric-oxygen-treatment-did-not-significantly-affect-radiation-injury-in-the-mandibular-area-of-rats
#5
Tonje Sønstevold, Anne Christine Johannessen, Rolf K Reed, Gerd S Salvesen, Linda Stuhr
OBJECTIVE: Hyperbaric oxygen therapy (HBOT) has been used to enhance microcirculation and thereby oxygen tension in tissues. The present study aimed to investigate the effect of HBOT on radiation injury in the mandibular area of rats. STUDY DESIGN: The left mandibles of rats were irradiated by external radiotherapy (15 Gy every other week for a total of 75 Gy). Four HBOT strategies were used: 2 prophylactic groups receiving HBOT either between each radiation treatment or immediately following terminated radiation treatment, and 2 therapeutic groups receiving HBOT after the latent period of 6 weeks after irradiation either every day (standard HBOT protocol) or 3 days a week for 6 weeks...
November 2, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29237344/epithelial-myoepithelial-carcinoma-of-the-nasal-cavity-clinical-histopathological-and-immunohistochemical-distinction-of-a-case-report
#6
Sally Nguyen, Marjorie Perron, Sylvie Nadeau, Alexandre Nakao Odashiro, Marie-Noëlle Corriveau
BACKGROUND: Epithelial myoepithelial carcinomas (EMCs) are rare low-grade salivary gland tumors. Here, we report the case of a 75-year-old man presenting with an oncocytic variant of EMC of the nasal cavity, initially diagnosed as an oncocytoma. METHODS: Our patient underwent functional sinus surgery in 2012. On pathology, an oncocytic neoplasm was found in the right nasal cavity, characterized by fragments of uniform bland oncocytic cells with bilayered arrangement of nuclei...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29172327/head-and-neck-cancer-patients-%C3%A2-information-for-the-general-dental-practitioner
#7
Jennifer Noone, Craig Barclay
Salivary gland damage is the most common adverse effect associated with radiation therapy to the head and neck. A combination of hyposalivation and dietary changes, with a reduced emphasis on oral hygiene practices can contribute to a massive increase in a person’s caries risk status. This can be further complicated by limited mouth opening. To enable optimal dental care for head and neck cancer patients before, during and after radiation therapy, patients must be informed and educated about the potential risks of dental caries and the preventive strategies available...
March 2017: Dental Update
https://www.readbyqxmd.com/read/29151106/survival-outcome-of-intermediate-grade-salivary-gland-carcinoma
#8
Gi Cheol Park, Jong-Lyel Roh, Kyung-Ja Cho, Yong Gi Jung, Hyoun Wook Lee, Tae Gyu Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVE: Histological grade is the most important factor for defining treatment strategies and predicting prognosis for salivary gland carcinoma (SGC). We examined factors affecting long-term recurrence and survival among intermediate-grade SGC (IGSGC) patients to define optimal treatment modalities and outcomes. METHODS: We reviewed the clinical and pathological data on 108 IGSGC patients who underwent definitive surgery with or without postoperative radiotherapy...
November 18, 2017: Oncology
https://www.readbyqxmd.com/read/29147434/acute-radiation-induced-changes-in-sprague-dawley-rat-submandibular-glands-a-histomorphometric-analysis
#9
Manu Krishnan, Aatish Tennavan, Seema Saraswathy, Tarun Sekhri, Ajay Kumar Singh, Velu Nair
Background: Radiation-induced xerostomia is a distressing clinical condition that starts appearing from the initial stages of radiotherapy in head and neck cancer patients. Though submandibular glands contribute to maximum of the "resting salivary" secretions, most of the acute xerostomia experiments so far reported have been on animal parotid glands. Therefore, we assessed and quantified the histologic changes in submandibular glands of Sprague-Dawley (SD) rats using histomorphometry, 24 hours after radiation...
April 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29109791/can-molecular-profiling-enhance-radiotherapy-impact-of-personalized-targeted-gold-nanoparticles-on-radiosensitivity-and-imaging-of-adenoid-cystic-carcinoma
#10
Inbal Hazkani, Menachem Motiei, Oshra Betzer, Tamar Sadan, Dimitri Bragilovski, Leon Lubimov, Aviram Mizrachi, Tuvia Hadar, Mattan Levi, Irit Ben-Aharon, Izhack Haviv, Rachela Popovtzer, Aron Popovtzer
Personalized molecular profiling has an established role in selection of treatment for metastatic disease; however, its role in improving radiosensitivity and functional imaging has not been evaluated. In the current study, we examined molecular profiling as a tool for designing personalized targeted gold nanoparticles (GNP) to serve as dual-modal tumor radiosensitizers and functional imaging enhancers. To this end, molecular profiling of a patient's salivary gland adenoid cystic carcinoma (ACC) was performed, and anaplastic lymphoma kinase (ALK) mutation was detected...
2017: Theranostics
https://www.readbyqxmd.com/read/29105949/a-model-for-predicting-the-dose-to-the-parotid-glands-based-on-their-relative-overlapping-with-planning-target-volumes-during-helical-radiotherapy
#11
Cheryl H Millunchick, Heming Zhen, Gage Redler, Yixiang Liao, Julius V Turian
The sparing of the parotid glands in the treatment of head and neck cancers is of clinical relevance as high doses to the salivary glands may result in xerostomia. Xerostomia is a major cause of decreased quality of life for head and neck patients. This paper explores the relationship between the overlap of the target volumes and their expansions with the parotid glands for helical delivery plans and their ability to be spared. Various overlapping volumes were examined, and an overlap with a high statistical relevance was found...
November 6, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29100750/oncocytic-carcinoma-of-the-salivary-glands-a-danish-national-study
#12
Marie Westergaard-Nielsen, Christian Godballe, Lisbeth Juhler Andersen, Hanne Primdahl, Claus A Kristensen, Elo Andersen, Kristine Bjørndal
OBJECTIVES: To present a Danish national series of oncocytic carcinoma (OC) patients, including data on treatment, recurrence and survival. METHODS: From the national Danish database of salivary gland carcinomas, all patients diagnosed with OC from 1990 to 2005 were identified and data concerning demographics, tumor site, clinical stage and treatment profiles were extracted. A follow-up was carried out. RESULTS: Of the 15 cases of salivary gland OC, eight were female...
October 31, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29093739/aggressive-adenoid-cystic-carcinoma-of-maxillary-sinus-in-a-43-year-old-male-rare-case-report-and-review-of-literature
#13
Koorosh Rahmani, Shokouh Taghipour Zahir, Mohammad Baghi Yazdi, Alireza Navabazam
Adenoid cystic carcinoma (ACC) is a rare malignant tumor, mostly involving the minor salivary glands. Herein, we present a case of ACC in a 43-year-old man with symptoms of dental abscess as the initial presentation of the tumor. In spiral computed tomography (CT) scan, soft tissue mass with the erosion of maxillary sinus wall on the right side of the alveolar ridge was evident. Histopathological examination of the excised tumor with immunohistochemical studies (C-kit, Vimentin, pan-cytokeratin, p53, p63, and ki67 positive reaction) confirmed grade 2 ACC in the maxillary sinus...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29019545/a-brief-history-of-salivary-gland-surgery
#14
Giulianno Molina Melo, Onivaldo Cervantes, Marcio Abrahao, Luciene Covolan, Elenn Soares Ferreira, Heloisa Allegro Baptista
Salivary gland neoplasms are a relatively uncommon disease, with nearly one case per 100.000 adults estimated per year and an overall incidence of 1% of all neoplasms. The benign neoplasms are majority and the prognosis depends on the histologic type, grade, localization, soft tissue infiltration, regional and distant metastasis. The main treatment is surgery with caution to facial nerve in the major salivary glands, followed by radiotherapy and chemotherapy in selected cases. The objective of this review is to provide the lector an historic approach about salivary gland diseases treatment, with special attention to the parotid neoplasms and its peculiarities associated to those who studied these glands in their history course...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28955679/polymorphous-low-grade-adenocarcinoma-of-the-parotid-in-a-teenager
#15
Divya Khosla, Shalini Verma, Nitin Gupta, Rajpal-S Punia, Gurbir Kaur, Awadhesh-K Pandey, Kislay Dimri
INTRODUCTION: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance. CASE REPORT: A 16-year-old male presented with recurrent painless swelling in the right preauricular region and with a history of surgical intervention at the same site in the past...
September 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28951700/adaptive-radiotherapy-in-a-case-of-adenoid-cystic-carcinoma-of-bronchus-and-its-favourable-impact-on-treatment-outcome-a-case-report
#16
Suman Das, Yogaraja Dorairaja, Anandakrishnan Kuppusamy
Adenoid cystic carcinoma is a very rare malignancy commonly originating from the salivary glands of the head and neck. It is again very scantily seen in sites like the bronchus. Surgical resection is the mainstay of treatment but many a times the tumour site and size preclude a favourable outcome of surgery and the patient is advised for other forms of local treatment like Radiotherapy. Here, we present a case report of a young female with primary adenoid cystic carcinoma of the bronchus. The tumour was located in the carina and the left bronchus which was obstructing the airway resulting in collapse of the left lung, this resulted in shifting the mediastinum and abdominal structures in to the thorax...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28936637/significant-prognostic-factors-affecting-treatment-outcomes-of-salivary-gland-carcinoma-a-multicenter-retrospective-analysis
#17
Shin-Ichi Yamada, Hiroshi Kurita, Takahiro Kamata, Tadaaki Kirita, Michihiro Ueda, Tetsuro Yamashita, Yoshihide Ota, Mitsunobu Otsuru, Nobuhiro Yamakawa, Masaya Okura, Tomonao Aikawa, Masahiro Umeda
The purpose of this study was to investigate the prognostic factor in salivary gland carcinoma patients. Clinical and pathological data of 211 consecutive patients who treated with curative intent were analyzed. The overall survival (OS) rate, local control rate, and distant metastasis rate were calculated. To examine a prognostic factor in salivary gland carcinoma patients, a multivariate analysis was performed. The 5-year-OS rate was 84.0%, and 10-year was 69.2%. The 5-year-local control rate was 84.6%, and 10-year was 70...
September 21, 2017: Odontology
https://www.readbyqxmd.com/read/28935487/clinical-prognostic-factors-of-salivary-adenoid-cystic-carcinoma-a%C3%A2-single-center-analysis-of-61-patients
#18
Robert Cordesmeyer, Henning Schliephake, Philipp Kauffmann, Markus Tröltzsch, Rainer Laskawi, Philipp Ströbel, Felix Bremmer
PURPOSE: Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years. MATERIALS AND METHODS: In all 61 patients with salivary adenoid cystic carcinoma, clinical data, demographic data, risk factors, tumor location, tumor stage, status of surgical margin, surgical treatment, postoperative radiotherapy and follow-up interval were assessed...
August 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28918183/survival-after-surgery-for-oral-cancer-a-30-year-experience
#19
T K Ong, C Murphy, A B Smith, A N Kanatas, D A Mitchell
Oral squamous cell carcinoma is the most common intraoral malignancy, for which we advocate radical primary resection with adjuvant treatment where indicated. The main aims of this paper are to identify the overall survival of a consecutive series of patients and to relate survival to clinical and pathological factors. Kaplan-Meier curves were produced for site, sex, TNM status, and use of postoperative radiotherapy. The data were analysed using IBM SPSS Statistics for Windows and probabilities of less than 0...
September 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28893025/primary-squamous-cell-carcinoma-of-submandibular-salivary-gland-a-case-report
#20
Manmohan Agarwal, Lakshmi Agarwal, Rajeev Saxena
Primary Squamous Cell Carcinoma (PSCC) of submandibular salivary gland is a rare occurrence. Careful clinical and histopathological examination is must to diagnose it. The treatment protocol of this rare disease is not clearly defined. Though surgery is primary treatment, role of adjuvant treatment is not clear. A 40-year-old male presented to us with asymptomatic upper neck swelling. Triple endoscopy, cross-sectional investigation and FNAC suggested primary squamous cell carcinoma of right submandibular salivary gland...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
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