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Salivary glands radiotherapy

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https://www.readbyqxmd.com/read/27882233/high-dose-rate-brachytherapy-for-local-recurrent-adenoid-cystic-carcinoma-of-the-tongue-base-following-postoperative-external-beam-radiotherapy
#1
Sun Young Lee, Jung Soo Kim, Hyoung Cheol Kwon
Adenoid cystic carcinoma is a rare neoplasm commonly originating from the minor salivary glands. The clinical findings typical of this tumor include slow growth, perineural invasion and high frequency of local recurrence. In this study, a patient presented with a tongue base lesion that was treated with surgical excision and additional postoperative external beam radiotherapy. However, local recurrence occurred 8 months after radiotherapy. If recurrence occurs after radiation therapy, total glossectomy should be considered...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27846899/contribution-of-submandibular-gland-and-swallowing-structure-sparing-to-post-radiation-therapy-peg-dependence-in-oropharynx-cancer-patients-treated-with-split-neck-imrt-technique
#2
Michael F Gensheimer, Matthew Nyflot, George E Laramore, Jay J Liao, Upendra Parvathaneni
BACKGROUND: Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of this study was to determine whether SMG sparing IMRT is associated with reduced post-treatment PEG dependence in locally advanced oropharynx cancer patients. METHODS: Patients treated with definitive radiation therapy for oropharynx cancer were included in this retrospective study...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27846763/outcomes-after-primary-or-adjuvant-radiotherapy-for-salivary-gland-carcinoma
#3
Adam Holtzman, Christopher G Morris, Robert J Amdur, Peter T Dziegielewski, Brian Boyce, William M Mendenhall
BACKGROUND: We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies. MATERIALS AND METHODS: From 1964 to 2012, 291 patients received primary RT (n = 67) or RT combined with surgery (n = 224). RESULTS: The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively...
November 16, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27843342/the-danish-head-and-neck-cancer-database
#4
REVIEW
Jens Overgaard, Aleksandar Jovanovic, Christian Godballe, Jesper Grau Eriksen
AIM OF THE DATABASE: The Danish Head and Neck Cancer database is a nationwide clinical quality database that contains prospective data collected since the early 1960s. The overall aim of this study was to describe the outcome of the national strategy for multidisciplinary treatment of head and neck cancer in Denmark and to create a basis for clinical trials. STUDY POPULATION: The study population consisted of all Danish patients referred for treatment of squamous cell carcinoma of the larynx, pharynx, oral cavity, or neck nodes from unknown primary or any histopathological type (except lymphoma) of cancer in the nasal sinuses, salivary glands, or thyroid gland (corresponding to the International Classification of Diseases, tenth revision, classifications C...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27822061/clinicopathological-characteristics-treatment-and-survival-outcomes-of-cystadenocarcinoma-of-the-salivary-gland-a-population-based-study
#5
Cheng-Fu Cai, Jia-Yuan Sun, Zhen-Yu He, Huan-Xin Lin, Fa-Rong Liu, Yan Wang
BACKGROUND: The aim of this study was to investigate the clinicopathological characteristics, treatment, and survival of cystadenocarcinoma of the salivary gland. PATIENTS AND METHODS: Cases in the Surveillance, Epidemiology, and End Results database from 1991 to 2012 were identified. Factors significantly associated with survival were identified using Kaplan-Meier survival analysis and Cox proportional hazard regression. RESULTS: A total of 65 patients were identified; of these patients, 64 received surgical treatment, 25 underwent lymphadenectomy, and four (16...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27793123/invasive-myoepithelial-carcinoma-ex-pleomorphic-adenoma-of-the-major-salivary-gland-two-case-reports
#6
Takahiro Wakasaki, Marie Kubota, Yutaka Nakashima, Eri Tomonobe, Takenao Mihara, Junichi Fukushima
BACKGROUND: Myoepithelial carcinoma (MEC) is a rare salivary gland tumor. Its long-term prognosis remains unknown because of the paucity of reported cases with long-term follow-up. Although some case series exist, the clinical features of MEC vary considerably depending on the site of origin. Therefore, accumulation of these rare cases is important. CASE PRESENTATION: Case 1: An 89-year-old man presented with a 10-year history of a mass originating from the right parotid gland and involving the neck...
October 28, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27790562/toxicity-profile-of-imrt-vs-3d-crt-in-head-and-neck-cancer-a-retrospective-study
#7
Gopa Ghosh, Ramanjis Tallari, Anupam Malviya
INTRODUCTION: Role of radiotherapy in comprehensive management of head and neck cancer for achieving tumour control and organ preservation is now well established and radiotherapy is routinely used in adjuvant setting after surgery, concurrently with chemotherapy or targeted agents and for palliation. Development of linear accelerator with Multileaf Collimator (MLC) have revolutionized radiation delivery techniques, allowing conformal and Intensity Modulated Radiotherapy (IMRT) to deliver highly conformal sculpted radiation dose to a very complex structure with improved sparing of adjoining critical structures like salivary glands, spinal cord, eyes, brainstem and larynx amounting to better therapeutic gain...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27781194/mucoepidermoid-carcinoma-of-palatal-minor-salivary-glands-with-intracranial-extension-a-case-report-and-literature-review
#8
Rimal Hanif Dossani, Hesam Akbarian-Tefaghi, Lori Lemonnier, Vikas Mehta, Jamie A Jacobsohn, Bharat Guthikonda
Mucoepidermoid carcinoma (MEC) is one of the most common malignant tumors of both major and minor salivary glands. Although there are reports of parotid MEC tumors extending intracranially via the facial nerve, intracranial extension from MEC originating from minor salivary glands in the palate has not previously been reported. This report presents a case of MEC arising from the minor salivary glands of the palate and extending into the middle fossa via the foramen rotundum with perineural invasion of the maxillary division of the trigeminal nerve...
October 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27746885/locally-advanced-stage-high-grade-mucoepidermoid-carcinoma-of-salivary-gland-in-a-9-year-old-girl-the-controversy-of-adjuvant-therapy
#9
Olga Micol Martínez, Elena Daghoum Dorado, María Dolores Amorós García, María Isabel Oviedo Ramírez, Isabel de la Fuente Muñoz, Jose Luis Fuster Soler
Malignant salivary gland tumors are rare in children, mostly represented by low-grade mucoepidermoid carcinomas. For these patients, long-term survival rates above 95% are reported after surgical resection. Here we report a case of a 9-year-old girl with a high grade locally advanced mucoepidermoid carcinoma undergoing adjuvant radiotherapy and chemotherapy after surgery. We emphasize the controversy and lack of evidence-based indication for these highly toxic adjuvant therapy modalities in children.
September 5, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27734981/malignant-salivary-gland-tumours-of-the-larynx-a-single-institution-review
#10
S Karatayli-Ozgursoy, J A Bishop, A T Hillel, L M Akst, S R Best
Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27694779/oral-tongue-cancer-in-public-hospitals-in-madrid-spain-1990-2008
#11
A-I García-Kass, A Herrero-Sánchez, G Esparza-Gómez
BACKGROUND: The cancer which appears in the mobile portion of the tongue is the most common neoplasm of the oral cavity. The objective of this study was to analyse oral tongue cancer epidemiology in a population of 610 patients diagnosed between 1990 and 2008 and detailed in the Tumour Registry of the Madrid region. MATERIAL AND METHODS: A retrospective analysis based on the following variables provided in the Tumour Registry was achieved: age, gender, histology, stage, location, treatment...
November 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27637993/salivary-amylase-as-a-marker-of-salivary-gland-function-in-patients-undergoing-radiotherapy-for-oral-cancer
#12
V K Vaishnavi Vedam, Karen Boaz, Srikant Natarajan, Sivadas Ganapathy
BACKGROUND: The aim of this study was to evaluate salivary amylase in patients with primary oral cancer undergoing radiotherapy as the main modality of treatment. MATERIALS/METHODS: The study was conducted on ten histologically proven cases of oral cancer undergoing radiotherapy. Stimulated whole saliva was collected at three stages of radiotherapy-0, 3, and 6 weeks. Salivary amylase was estimated using Henry-Chiamori method and comparison was made with appropriate age- and gender-matched controls...
September 17, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27636993/t4-n2-classification-nasopharyngeal-carcinoma-benefit-from-concurrent-chemotherapy-in-the-era-of-intensity-modulated-radiotherapy
#13
Ruifei Xie, Bing Xia, Xuebang Zhang, Wei Hu, Ruping Zhao, Congying Xie, Jianhua Wang, Ni Zhang, Shixiu Wu
Although the benefits of concurrent chemotherapy (CC) in the treatment of locally advanced nasopharyngeal carcinoma (NPC) had been proven in the era of two-dimensional radiotherapy, long-term efficacy and safety of using CC combined with intensity-modulated radiotherapy (IMRT) remain unclear. A retrospective analysis of 1,182 patients who underwent IMRT for clinical II-Iva NPC was performed. Propensity score matching algorithm was used to identify two matched cohorts with or without CC (264 patients per cohort)...
September 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27627138/predictors-for-trismus-in-patients-receiving-radiotherapy
#14
S Joyce van der Geer, Jolanda I Kamstra, Jan L N Roodenburg, Marianne van Leeuwen, Harry Reintsema, Johannes A Langendijk, Pieter U Dijkstra
BACKGROUND: Trismus, a restricted mouth opening in head and neck cancer patients may be caused by tumor infiltration in masticatory muscles, radiation-induced fibrosis or scarring after surgery. It may impede oral functioning severely. The aims of our study were to determine: (1) the incidence of trismus at various time points; and (2) the patient, tumor, and treatment characteristics that predict the development of trismus after radiotherapy in head and neck cancer patients using a large database (n = 641)...
November 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27614524/-intensity-modulated-radiotherapy-for-head-and-neck-cancer-dose-constraint-for-salivary-gland-and-mandible
#15
Y Pointreau, T Lizée, R-J Bensadoun, P Boisselier, S Racadot, J Thariat, P Graff
Intensity-modulated radiation therapy (IMRT) is the gold standard for head and neck irradiation. It allows better protection to the organs at risk such as salivary glands and mandible, and can reduce the frequency of xerostomia, trismus and osteoradionecrosis. At the time of treatment planning, the mean dose to a single parotid gland should be kept below 26Gy, the mean dose to a single submandibular gland below 39Gy, the mean dose to the mandible below 60 to 65Gy and the D2% to a single temporomandibular joint below 65Gy...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27611841/investigating-the-effect-of-ligand-amount-and-injected-therapeutic-activity-a-simulation-study-for-177lu-labeled-psma-targeting-peptides
#16
Peter Kletting, Christiane Schuchardt, Harshad R Kulkarni, Mostafa Shahinfar, Aviral Singh, Gerhard Glatting, Richard P Baum, Ambros J Beer
In molecular radiotherapy with 177Lu-labeled prostate specific membrane antigen (PSMA) peptides, kidney and/or salivary glands doses limit the activity which can be administered. The aim of this work was to investigate the effect of the ligand amount and injected activity on the tumor-to-normal tissue biologically effective dose (BED) ratio for 177Lu-labeled PSMA peptides. For this retrospective study, a recently developed physiologically based pharmacokinetic model was adapted for PSMA targeting peptides. General physiological parameters were taken from the literature...
2016: PloS One
https://www.readbyqxmd.com/read/27556786/accuracy-of-software-assisted-contour-propagation-from-planning-ct-to-cone-beam-ct-in-head-and-neck-radiotherapy
#17
Christian A Hvid, Ulrik V Elstrøm, Kenneth Jensen, Markus Alber, Cai Grau
BACKGROUND: Autocontouring improves workflow in computed tomography (CT)-based dose planning, but could also potentially play a role for optimal use of daily cone beam CT (CBCT) in adaptive radiotherapy. This study aims to determine the accuracy of a deformable image registration (DIR) algorithm for organs at risk (OAR) in the neck region, when applied to CBCT. MATERIAL AND METHODS: For 30 head and neck cancer (HNC) patients 14 OARs including parotid glands, swallowing structures and spinal cord were delineated...
November 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27556664/multidisciplinary-management-of-salivary-gland-cancers
#18
Matthew J Mifsud, Jon N Burton, Andy M Trotti, Tapan A Padhya
BACKGROUND: Salivary carcinomas are a rare group of biologically diverse neoplasms affecting the head and neck. The wide array of different histological entities and clinical presentations has historically limited attempts to establish well-defined treatment algorithms. In general, low-risk lesions can be managed with a single treatment modality, whereas advanced lesions require a more complex, multidisciplinary approach. METHODS: The relevant literature was reviewed, focusing on diagnostic and treatment algorithms for salivary malignancies...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27541166/association-of-adjuvant-chemoradiotherapy-vs-radiotherapy-alone-with-survival-in-patients-with-resected-major-salivary-gland-carcinoma-data-from-the-national-cancer-data-base
#19
Arya Amini, Timothy V Waxweiler, Jeffrey V Brower, Bernard L Jones, Jessica D McDermott, David Raben, Debashis Ghosh, Daniel W Bowles, Sana D Karam
Importance: Data on adjuvant concurrent chemoradiotherapy (CRT) after resection of salivary gland carcinomas (SGCs) are limited. Objective: To examine overall survival (OS) outcomes of patients who receive CRT vs radiotherapy (RT) alone after resection of SGCs. Design, Setting, and Participants: The National Cancer Data Base (NCDB), a hospital-based registry that represents 70% of all cancer cases in the United States, was queried for patients who underwent resection of major SGCs with at least 1 high-risk feature (T3-T4 stage, N1-N3 stage, or positive margins)...
November 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27538846/imrt-for-head-and-neck-cancer-reducing-xerostomia-and-dysphagia
#20
XiaoShen Wang, Avraham Eisbruch
Dysphagia and xerostomia are the main sequellae of chemoradiotherapy for head and neck cancer, and the main factors in reducing long-term patient quality of life. IMRT uses advanced technology to focus the high radiation doses on the targets and avoid irradiation of non-involved tissues. The decisions about sparing organs and tissues whose damage causes xerostomia and dysphagia depends on the evidence for dose-response relationships for the organs causing these sequellae. This paper discusses the evidence for the contribution of radiotherapy to xerostomia via damage of the major salivary glands (parotid and submandibular) and minor salivary glands within the oral cavity, and the contribution of radiotherapy-related effect on important swallowing structures causing dysphagia...
August 2016: Journal of Radiation Research
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