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https://www.readbyqxmd.com/read/29126216/pager-2-0-an-update-to-the-pathway-annotated-list-and-gene-signature-electronic-repository-for-human-network-biology
#1
Zongliang Yue, Qi Zheng, Michael T Neylon, Minjae Yoo, Jimin Shin, Zhiying Zhao, Aik Choon Tan, Jake Y Chen
Integrative Gene-set, Network and Pathway Analysis (GNPA) is a powerful data analysis approach developed to help interpret high-throughput omics data. In PAGER 1.0, we demonstrated that researchers can gain unbiased and reproducible biological insights with the introduction of PAGs (Pathways, Annotated-lists and Gene-signatures) as the basic data representation elements. In PAGER 2.0, we improve the utility of integrative GNPA by significantly expanding the coverage of PAGs and PAG-to-PAG relationships in the database, defining a new metric to quantify PAG data qualities, and developing new software features to simplify online integrative GNPA...
November 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29113182/pteisolic-acid-g-a-novel-ent-kaurane-diterpenoid-inhibits-viability-and-induces-apoptosis-in-human-colorectal-carcinoma-cells
#2
Shuangli Qiu, Xin Wu, Hongbo Liao, Xiaobin Zeng, Senwang Zhang, Xiaofen Lu, Xiaohong He, Xiaoqi Zhang, Wencai Ye, Hua Wu, Xiaohui Zhu
Human colorectal cancer (CRC) is a major cause of cancer morbidity and mortality, and its incidence rates are increasing in economical transitioning areas globally. To develop efficient chemotherapy drugs for CRC, the present study isolated and identified a novel ent-kaurane diterpenoid from Pteris semipinnata, termed pterisolic acid G (PAG). This ent-kaurane diterpenoid was demonstrated to significantly inhibit the growth of human CRC HCT116 cells in a time- and dose-dependent manner, determined using the Cell Counting Kit-8 assay...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29107770/nocebo-induced-modulation-of-cerebral-itch-processing-an-fmri-study
#3
Missanga F van de Sand, Mareike M Menz, Christian Sprenger, Christian Büchel
It has been shown repeatedly that perceiving itch-related pictures or listening to a lecture on itch can enhance itch sensation and scratching behaviour (Niemeier and Gieler, 2000; Holle et al., 2012; Lloyd et al., 2013), indicating that itch is strongly influenced by expectations. Using fMRI, we investigated the neural correlates of the itch-related nocebo effect in healthy male and female human subjects. Itch sensation on the left forearm was induced by cutaneous histamine application and thermally modulated, with cooling leading to higher itch...
October 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29106919/using-quality-improvement-methodology-to-improve-ovarian-salvage-for-benign-ovarian-masses
#4
Jennifer H Aldrink, Dani O Gonzalez, Stephen P Sales, Katherine J Deans, Gail E Besner, Geri D Hewitt
PURPOSE: Most ovarian masses in children are benign and potentially amenable to ovarian salvage surgery (OSS). Despite the common use of OSS among pediatric and adolescent gynecologists (PAG) in recognition of reproductive and hormonal health advantages, this technique is not commonly performed by pediatric surgeons. The aim of this quality improvement (QI) initiative was to improve our institutional rate of OSS for benign ovarian masses. METHODS: Baseline data were obtained retrospectively from surgical procedures performed for benign ovarian masses between January 2012 and February 2016...
October 10, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29096218/feasibility-of-deep-brain-stimulation-for-controlling-the-lower-urinary-tract-functions-an-animal-study
#5
Shih-Ching Chen, Pei-Yi Chu, Tsung-Hsun Hsieh, Yu-Ting Li, Chih-Wei Peng
OBJECTIVE: To evaluate the feasibility of deep brain stimulation (DBS) and compare the potential of four DBS targets in rats for regulating bladder activity: the periaqueductal gray (PAG), locus coeruleus (LC), rostral pontine reticular nucleus (PnO), and pedunculopontine tegmental nucleus (PPTg). METHODS: A bipolar stimulating electrode was implanted. The effects of DBS on the inhibition and activation of micturition reflexes were investigated by using isovolumetric intravesical pressure recordings...
September 30, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29091875/role-of-endogenous-hydrogen-sulfide-in-cardiac-mitochondrial-preservation-during-ischemia-reperfusion-injury
#6
Sanhitha Nandi, Sriram Ravindran, Gino A Kurian
Cardio-protective effect of hydrogen sulfide (H2S) against myocardial ischemia reperfusion injury (I/R) via preservation of mitochondria is well documented. But the distinct role of exogenous and endogenous H2S in cardio-protection and its dependency on functional cardiac mitochondria is not understood. The present study was designed to investigate the role of exogenous H2S preconditioning on cardiac mitochondrial subpopulation namely interfibrillar (IFM) and subsarcolemmal (SSM), in attenuating I/R injury in an isolated rat heart model in the absence of endogenous H2S production...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29083203/brief-optogenetic-inhibition-of-rat-lateral-or-ventrolateral-periaqueductal-gray-augments-the-acquisition-of-pavlovian-fear-conditioning
#7
Neda Assareh, Elena E Bagley, Pascal Carrive, Gavan P McNally
The midbrain periaqueductal gray (PAG) coordinates the expression and topography of defensive behaviors to threat and also plays an important role in Pavlovian fear learning itself. Whereas the role of PAG in the expression of defensive behavior is well understood, the relationship between the activity of PAG neurons and fear learning, the exact timing of PAG contributions to learning during the conditioning trial, and the contributions of different PAG columns to fear learning are poorly understood. We assessed the effects of optogenetic inhibition of lateral (LPAG) and ventrolateral PAG (VLPAG) neurons on fear learning...
October 30, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29082704/-absorption-enhancing-effects-and-safety-of-pamam-dendrimers-on-liquiritin
#8
Wen-Jun Qu, Hui-Fang Li, Yuan-Yuan Su, Zheng-Qi Dong, Yan-Ru Ge
PAMAM dendrimer is one of the most widely studied dendrimers in recent years, which has a large number of functional groups on the surface and cavities inside, specific three-dimensional structure and good biocompatibility, permeability and stability. It has been widely applied in drug and gene carrier fields and may become a new absorption enhancer. In order to study the absorption enhancing effects of PAMAM dendrimers, liquiritin was selected as the model drug, with the protection of spleen and liver, detoxification and other functions, but it had not been widely used in clinical application because of its difficult absorption, first pass effect, and low bioavailability...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29073542/pregnancy-diagnosis-in-cattle-using-pregnancy-associated-glycoprotein-concentration-in-circulation-at-day-24-of-gestation
#9
S T Reese, M H C Pereira, J L Edwards, J L M Vasconcelos, K G Pohler
Cattle producers are limited to day 28-30 of gestation as the earliest time point for accurate pregnancy diagnosis due to the effectiveness of ultrasound and chemical based methods, including commercially available pregnancy associated glycoproteins (PAG) tests. The objective of the current studies were to determine if early gestation circulating PAG concentrations at day 24 could be used to diagnose pregnancy in dairy cattle undergoing embryo transfer. In vitro produced embryos were transferred into Holstein x Gir cows and heifers on day 7 following ovulation...
October 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/29070724/amygdala-midbrain-connectivity-indicates-a-role-for-the-mammalian-parental-care-system-in-human-altruism
#10
Kristin M Brethel-Haurwitz, Katherine O'Connell, Elise M Cardinale, Maria Stoianova, Sarah A Stoycos, Leah M Lozier, John W VanMeter, Abigail A Marsh
Costly altruism benefitting a stranger is a rare but evolutionarily conserved phenomenon. This behaviour may be supported by limbic and midbrain circuitry that supports mammalian caregiving. In rodents, reciprocal connections between the amygdala and the midbrain periaqueductal grey (PAG) are critical for generating protective responses toward vulnerable and distressed offspring. We used functional and structural magnetic resonance imaging to explore whether these regions play a role in supporting costly altruism in humans...
October 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29062273/extracting-neural-oscillation-signatures-of-laser-induced-nociception-in-pain-related-regions-in-rats
#11
Xuezhu Li, Zifang Zhao, Jun Ma, Shuang Cui, Ming Yi, Huailian Guo, You Wan
Previous studies have shown that multiple brain regions are involved in pain perception and pain-related neural processes by forming a functionally connected pain network. It is still unclear how these pain-related brain areas actively work together to generate the experience of pain. To get a better insight into the pain network, we implanted electrodes in four pain-related areas of rats including the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), primary somatosensory cortex (S1) and periaqueductal gray (PAG)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29042065/analgesic-and-anxiolytic-effects-of-leu-31-pro-34-neuropeptide-y-microinjected-into-the-periaqueductal-gray-in-rats
#12
Priscila Vázquez-León, Luis G Mendoza-Ruiz, Eduardo Ramírez-San Juan, German Alberto Chamorro-Cevallos, Abraham Miranda-Páez
Several reports have demonstrated that neuropeptide Y (NPY) is involved in food intake, epilepsy, circadian rhythms, drug seeking, pain and anxiety, and other physiological or pathological conditions. On the other hand, periaqueductal gray (PAG) is a key brain center for modulating pain, anxiety and fear. It is the main structure implicated in integrated defensive behaviors. One such behavior, tonic immobility (TI), resembles fear and is able to induce analgesia. After microinjection of [Leu(31),Pro(34)]-Neuropeptide Y ([Leu(31),Pro(34)]-NPY) into the PAG dorsal (D) or ventrolateral (VL) of adult male Wistar rats, the following parameters were assessed: i) the analgesic effect by means of the tail-flick test (TF), ii) the duration of TI as a passive defensive behavioral response and as an anxiety/fear model (considering both TF and TI as single behaviors), iii) TI-induced analgesia by the combination of TF/TI, and iv) the anxious-like state through the elevated plus maze (EPM), and defensive burying behavior (DBB)...
October 12, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29039565/hydrogen-sulfide-regulates-bone-remodeling-and-promotes-orthodontic-tooth-movement
#13
Haiya Pu, Yongmei Hua
Hydrogen sulfide (H2S) is a gas signaling molecule that has multiple influences on physiological and pathological processes in the mammalian body, including vasodilation, neurotransmission, inflammation, hypoxia sensing and bone remodeling. Our previous studies suggested that H2S might be involved in the periodontal tissue remodeling during the orthodontic tooth movement (OTM) via increasing periodontal ligament cell differentiation, tissue mineralization, bone formation and collagen synthesis. The aim of the present study was to investigate the effects of H2S on alveolar bone remodeling that is associated with tooth movement...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29036974/-the-impact-of-hydrogen-sulfide-on-the-heme-oxygenase-1-carbon-monoxide-system-in-coxsackie-virus-b3-induced-myocarditis-in-mice
#14
S Y Zhang, T T Wu, Y Ren, T H Xia, R Z Wu
Objective: To explore the impact of hydrogen sulfide (H(2)S) on the heme oxygenase-1/carbon monoxide pathway in Coxsackie virus B3 (CVB3)-induced murine myocarditis (VMC) model. Method: A total of 70 inbred male Balb/c mouse (4-6 weeks old) were randomized into the following four groups: Normal, VMC, PAG and NaHS (n=10 for Normal, n=20 for VMC, PAG and NaHS groups). Mice in Normal group were non-infected mice treated with intraperitoneal injection of sterile phosphate-buffered saline daily for 10 days.Mice in VMC group received intraperitoneal CVB3 injection (0...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29035918/dopaminergic-mechanisms-in-periaqueductal-gray-mediated-antinociception
#15
Glaucia Tobaldini, Rafael A Reis, Natalia F Sardi, Mayla K Lazzarim, Dabna H Tomim, Marcelo M S Lima, Luana Fischer
As important as perceiving pain is the ability to modulate this perception in some contextual salient situations. The periaqueductal gray (PAG) is perhaps the most important site of endogenous pain modulation; however, little is known about dopaminergic mechanisms underlying PAG-mediated antinociception. In this study, we used a pharmacological approach to evaluate this subject. We found that µ-opioid receptor-induced antinociception (DAMGO, 0.3 μg) from PAG was blocked by the coadministration of either D1-like or D2-like dopaminergic antagonists (SCH23390, 2, 4, and 6 μg or raclopride, 2 and 4 μg, respectively) both in the tail-flick and in the mechanical paw-withdrawal test...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29032721/estimation-of-sensitivity-and-specificity-of-pregnancy-diagnosis-using-transrectal-ultrasonography-and-elisa-for-pregnancy-associated-glycoprotein-in-dairy-cows-using-a-bayesian-latent-class-model
#16
R W Shephard, J M Morton
AIMS: To determine the sensitivity (Se) and specificity (Sp) of pregnancy diagnosis using transrectal ultrasonography and an ELISA for pregnancy-associated glycoprotein (PAG) in milk, in lactating dairy cows in seasonally calving herds approximately 85-100 days after the start of the herd's breeding period. METHODS: Paired results were used from pregnancy diagnosis using transrectal ultrasonography and ELISA for PAG in milk carried out approximately 85 and 100 days after the start of the breeding period, respectively, from 879 cows from four herds in Victoria, Australia...
January 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29028769/activation-of-the-nuclear-receptor-fxr-improves-intestinal-cell-tolerance-to-ischemia-reperfusion-injury
#17
Xuan Wang, Shuo Li, Man Chen, Jing Liu, Ruirui Dong, Humin Wang, Shigong Zhu
The farnesoid X receptor (FXR) plays an important role in bile acid metabolism, intestinal homeostasis, and intestinal ischemia-reperfusion (I/R) injury. We aimed to clarify the potential effects of FXR on intestinal epithelial cell tolerance to intestinal I/R injury and reveal the underlying mechanisms. An intestinal I/R injury model was established by the occlusion of the superior mesenteric artery for ischemia for 1 h, followed by reperfusion for 4 h in C57BL/6 (wild-type; WT)and FXR mice. The small intestine injury was assessed by histological analysis...
October 12, 2017: Shock
https://www.readbyqxmd.com/read/28993250/monoaminergic-descending-pathways-contribute-to-modulation-of-neuropathic-pain-by-increasing-intensity-treadmill-exercise-after-peripheral-nerve-injury
#18
Victor M Lopez-Alvarez, Maria Puigdomenech, Xavier Navarro, Stefano Cobianchi
This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR performed during the first 2weeks after injury. Marked decrease in the expression of 5HT2A and α1A and β-, but not α2A adrenergic receptors in the spinal cord dorsal horn was associated to SNTR and recovered by iTR, particularly in lamina II...
October 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28987588/characterization-of-luteal-dynamics-in-lactating-holstein-cows-for-32-days-after-synchronization-of-ovulation-and-timed-artificial-insemination
#19
A Ricci, P D Carvalho, M C Amundson, P M Fricke
Approximately 20 to 30% of cows diagnosed not pregnant 32 d after timed artificial insemination (TAI) lack a corpus luteum (CL), and cows submitted to a resynchronization protocol in the absence of a CL have about 10% fewer pregnancies per AI (P/AI) than cows with a CL. An understanding of luteal dynamics after synchronization of ovulation and TAI may help refine strategies for reinseminating cows failing to conceive. Lactating Holstein cows (n = 141) were synchronized for first TAI using a Double-Ovsynch protocol...
October 4, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28987575/short-communication-the-effect-of-storage-conditions-and-storage-duration-on-milk-elisa-results-for-pregnancy-diagnosis
#20
E M Wynands, S J LeBlanc, D F Kelton
The objective of this study was to evaluate the effect of storage temperature and time from sample collection to analysis on test classification of a commercially available ELISA for diagnosis of pregnancy using the measurement of pregnancy-associated glycoproteins (PAG) in milk samples from dairy cows. Few studies have evaluated the effects of sample handling on milk PAG results. Using a repeated-measures study design, we evaluated sample storage at 5 temperatures: 37°C, 22°C, 4°C, -20°C, or -80°C. Sample aliquots from 45 cows (20 with a pregnant test result, 10 open, and 15 recheck) were stored for 4, 7, 14, 28, 60, 90, or 365 d...
October 4, 2017: Journal of Dairy Science
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