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https://www.readbyqxmd.com/read/29149792/case-management-for-people-with-dementia-and-its-translations-a-discussion-paper
#1
Steve Iliffe, Jane Wilcock, Michal Synek, Radek Carboch, Dana Hradcová, Iva Holmerová
Case management is generally seen as a way to provide efficient, cost-saving person-centred care for people with dementia by connecting together fragmented services, but the available evidence in favour of its merits is often considered inconclusive, unclear and sketchy. This discussion paper investigates the evidence of the benefit of case management for people with dementia and explores the complexity of the concept and the experiences of its implementation. It offers a comprehensive framework for conceptualising various types of case management and asks the question: who can be a case manager? Building on examples from three European countries it addresses the problem of the expansion and adoption of the case management method...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149791/the-dementia-care-coordination-program-engaging-health-systems-in-caregiver-supports
#2
Pamela Nadash, Nina M Silverstein, Frank Porell
This paper reports on a process evaluation using mixed methods to assess a Dementia Care Coordination Program, which is distinctive in using the medical system, rather than direct outreach, to identify and refer families to supports provided by an Alzheimer's Association chapter via dedicated care consultants. One care consultant received referrals from individual physicians, while the other, employed by a health plan, received referrals from health plan case managers. Through key informant interviews, focus groups, and physician and caregiver surveys, we identified key issues, finding high rates of stakeholder satisfaction, but some practical issues around information sharing and data tracking...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149782/frequency-of-circulatory-regulatory-immune-cells-in-iranian-patients-with-type-1-diabetes
#3
Tahereh Khamehchian, Eqlim Nemati, Marziyeh Jazayeri, Shirin Azimi, Hassan Nikoueinejad, Hossein Akbari, Behnaz Irandoust
Type 1 diabetes (T1D) is the result of the autoimmune destruction of insulin-producing beta cells. Regulatory T cells (Tregs) and plasmacytoid dendritic cells (PDCs) act as mediators of peripheral tolerance. We investigated the possible alterations of such cells in peripheral blood of patients with T1D compared to normal individuals. This comparison may lead to a better understanding of the immunopathogenesis processes involved in T1D. 92 participants, including 49 patients with T1D and 43 healthy controls were studied...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149780/interleukin-37-relieves-allergic-inflammation-in-a-house-dust-mite-allergic-rhinitis-murine-model
#4
Do Hyun Kim, Si Won Kim, Soo Whan Kim, Jun-Myung Kang
The purpose of this study was to investigate the effects of interleukin-37 (IL-37) on a Dermatophagoides farinae (Der f)-induced murine model of allergic rhinitis (AR). BALB/c mice, except the control groups, were sensitized intraperitoneally and challenged intranasally with Der f (Der f group). The IL-37 and IL-37+anti-CD25 groups were administered IL-37 intranasally. The IL-37+anti-CD25 groups were administered anti-CD25 monoclonal antibody intraperitoneally before challenge. Allergic symptoms and the average eosinophil number were counted...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149778/the-changes-of-th17-treg-and-related-cytokines-il-17-il-23-il-10-and-tgf-%C3%AE-in-respiratory-syncytial-virus-bronchiolitis-rat-model
#5
Meng Gao, Liang-Xiao Liu, Fu-Ling Wu, Xuejing Zhang, Ying-Ying Li, Tao Shi, De-Zhi Li, Ting-Ting Han
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and hospitalization that lead to high morbidity and mortality among young infants. T helper 17 (Th17) cells and regulatory T cells (Tregs) play essential roles in the pathogenesis of autoimmune, cancer, and inflammatory diseases. However, whether changes in T-cell subsets are related to the systemic immune responses in RSV-caused bronchiolitis merit further investigation. Three-week-old Sprague Dawley (SD) rats were randomly divided into the normal control (NC) and RSV bronchiolitis (RSV-B) groups...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149766/numerosity-estimation-benefits-from-transsaccadic-information-integration
#6
Carolin Hübner, Alexander C Schütz
Humans achieve a stable and homogeneous representation of their visual environment, although visual processing varies across the visual field. Here we investigated the circumstances under which peripheral and foveal information is integrated for numerosity estimation across saccades. We asked our participants to judge the number of black and white dots on a screen. Information was presented either in the periphery before a saccade, in the fovea after a saccade, or in both areas consecutively to measure transsaccadic integration...
November 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29149765/sorption-desorption-of-antimony-species-onto-calcined-hydrotalcite-surface-structure-and-control-of-competitive-anions
#7
Leonel Vinicius Constantino, Juliana Nunes Quirino, Taufik Abrão, Paulo Sérgio Parreira, Alexandre Urbano, Maria Josefa Santos
Calcined hydrotalcite can be applied to remove anionic contaminants from aqueous systems such as antimony species due to its great anion exchange capacity and high surface area. Hence, this study evaluated antimonite and antimonate sorption-desorption processes onto calcined hydrotalcite in the presence of nitrate, sulfate and phosphate. Sorption and desorption experiments of antimonite and antimonate were carried out in batch equilibrium and the post-sorption solids were analyzed by X-ray fluorescence (EDXRF)...
November 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29149754/the-effect-of-comorbid-depression-on-the-use-of-unscheduled-hospital-care-by-people-with-a-long-term-condition-a-retrospective-observational-study
#8
Tom Ricketts, Emily Wood, John Soady, David Saxon, Joe Hulin, Sally Ohlsen, Caroline Mitchell
BACKGROUND: The prevalence of long-term conditions (LTCs) and multiple-morbidity is increasing. Depression prevalence increases with the number of LTCs. Self-management of LTCs improves outcomes, but depression impacts on self-management. Unscheduled hospital care may be a proxy for failure of planned care to support successful self-management. METHODS: Retrospective observational study based on routine NHS datasets covering 19 LTCs. Prevalence of LTCs and depression was identified in all primary care registered adults in one English city (n = 469,368)...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149749/the-role-of-satellite-remote-sensing-in-structured-ecosystem-risk-assessments
#9
REVIEW
Nicholas J Murray, David A Keith, Lucie M Bland, Renata Ferrari, Mitchell B Lyons, Richard Lucas, Nathalie Pettorelli, Emily Nicholson
The current set of global conservation targets requires methods for monitoring the changing status of ecosystems. Protocols for ecosystem risk assessment are uniquely suited to this task, providing objective syntheses of a wide range of data to estimate the likelihood of ecosystem collapse. Satellite remote sensing can deliver ecologically relevant, long-term datasets suitable for analysing changes in ecosystem area, structure and function at temporal and spatial scales relevant to risk assessment protocols...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149748/in-situ-long-term-modeling-of-phenanthrene-dynamics-in-an-aged-contaminated-soil-using-the-vsoil-platform
#10
Khaled Brimo, Patricia Garnier, François Lafolie, Geoffroy Séré, Stéphanie Ouvrard
Management and remediation actions of polycyclic aromatic hydrocarbons (PAH) contaminated sites require an accurate knowledge of the dynamics of these chemicals in situ under real conditions. Here we developed, under the Virtual Soil Platform, a global model for PAH that describes the principal physical and biological processes controlling the dynamics of PAH in soil under real climatic conditions. The model was applied first to simulate the observed dynamics of phenanthrene in situ field experimental plots of industrial contaminated soil...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149738/associations-of-urinary-polycyclic-aromatic-hydrocarbon-metabolites-with-fractional-exhaled-nitric-oxide-and-exhaled-carbon-monoxide-a-cross-sectional-study
#11
Yun Zhou, Yuewei Liu, Huizhen Sun, Jixuan Ma, Lili Xiao, Limin Cao, Wei Li, Bin Wang, Jing Yuan, Weihong Chen
Exposure to Polycyclic aromatic hydrocarbons (PAHs) has been associated with inflammatory responses. Fractional exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) are both important inflammatory mediators especially in airways. However, few studies have investigated associations of PAH exposures with FeNO or eCO. Therefore, we aimed to quantify the associations of urinary PAH metabolites with FeNO and eCO levels, and investigate their potential effect modifiers by linear mixed models among 4133 participants from the Wuhan-Zhuhai cohort in China...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149731/purinergic-drug-targets-for-gastrointestinal-disorders
#12
REVIEW
Geoffrey Burnstock, Kenneth A Jacobson, Fievos L Christofi
Purinergic receptors are implicated in the pathogenesis of gastrointestinal disorders and are being explored as potential therapeutic targets. Gut inflammation releases ATP that acts on neuronal, glial, epithelial and immune cells. Purinergic signalling in glia and neurons is implicated in enteric neuropathies. Inflammation activates glia to increase ATP release and alter purinergic signalling. ATP release causes neuron death and gut motor dysfunction in colitis via a P2X7-dependent neural-glial pathway and a glial purinergic-connexin-43 pathway...
November 14, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29149730/divergence-of-insulin-superfamily-ligands-receptors-and-igf-binding-proteins-in-marine-versus-freshwater-stickleback-evidence-of-selection-in-known-and-novel-genes
#13
Tim Pellissier, Hend Al Nafea, Sara V Good
Three-spine stickleback (Gasterosteus aculeatus) is a teleost model for understanding genetic, physiological and morphological changes accompanying freshwater (FW) adaptation. There is growing evidence that the insulin superfamily plays important roles in traits involved in marine and FW adaptation. We performed a candidate gene analysis to look for evidence of selection on 33 insulin superfamily ligand-receptor genes and insulin-like growth factor binding proteins (Igfbp's) in stickleback. Using genotype data from 11 marine and 10 FW populations, we calculated the number of SNPs per site in regulatory and intronic regions, the number of synonymous and nonsynonymous mutations in coding regions, Wright's fixation index (Fst), and performed t-tests to identify SNPs with divergent genotype frequencies between marine/FW versus Atlantic/Pacific populations...
November 10, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29149729/functionalized-gold-nanoparticles-as-affinity-nanoprobes-for-multiple-lectins
#14
Karuppuchamy Selvaprakash, Yu-Chie Chen
Glycan-lectin interactions are commonly observed in nature. Analytical methods, which are used to detect lectins that rely on the use of glycan ligand-modified nanoprobes as affinity probes, have been developed. Most of the existing methods are focused on the use of synthetic glycan ligands. Nevertheless, naturally available glycoproteins, such as ovalbumin in chicken egg whites, are good sources for fabricating glycan-immobilized nanoprobes. In this study, we generated functionalized gold nanoparticles (Au NPs) from a one-pot reaction by reacting chicken egg white (cew) proteins with aqueous tetrachloroaurate...
November 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29149727/surface-modification-of-electrospun-poly-l-lactic-acid-scaffolds-by-reactive-magnetron-sputtering
#15
E N Bolbasov, P V Maryin, K S Stankevich, A I Kozelskaya, E V Shesterikov, Yu I Khodyrevskaya, M V Nasonova, D K Shishkova, Yu A Kudryavtseva, Y G Anissimov, S I Tverdokhlebov
In this study, we modified the surface of bioresorbable electrospun poly-(l-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity...
November 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29149725/a-method-for-the-design-of-ultrasonic-devices-for-scanning-acoustic-microscopy-using-impulsive-signals
#16
Mototaka Arakawa, Hiroshi Kanai, Kazuo Ishikawa, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo
Scanning acoustic microscopy (SAM) using impulsive signals is useful for characterization of biological tissues and cells. The operating center frequency of an ultrasonic device strongly depends on the performance characteristics of the device if the measurement is conducted by using impulsive signals. In this paper, a method for the design of ultrasonic devices for SAM using impulsive signals was developed. A new plane-wave model was introduced to calculate frequency characteristics of loss of ultrasonic devices by taking into account the conversion loss at the ultrasonic transducer, the transmission loss at the acoustic anti-reflection coating, and the propagation loss in the couplant...
November 2, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29149724/peri-ultrasound-modeling-for-surface-wave-propagation
#17
Mohammad Hadi Hafezi, Tribikram Kundu
The interaction between surface wave and a surface breaking crack is studied using a novel fast modeling tool called peri-ultrasound that can model both linear and nonlinear ultrasonic response. This modeling approach is based on peridynamic theory. In this study, the surface wave is modeled by applying a triangular pulse excitation function on the surface of a large structure. The particle movements are simulated on both sides of the surface crack to investigate transmitted and reflected fields. This investigation shows that: (1) the computed amplitude spectra of the Rayleigh wave agrees with the experimental observation; and (2) the structure containing a surface breaking crack shows noticeable increase in its nonlinear behavior...
November 7, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29149715/robust-brain-roi-segmentation-by-deformation-regression-and-deformable-shape-model
#18
Zhengwang Wu, Yanrong Guo, Sang Hyun Park, Yaozong Gao, Pei Dong, Seong-Whan Lee, Dinggang Shen
We propose a robust and efficient learning-based deformable model for segmenting regions of interest (ROIs) from structural MR brain images. Different from the conventional deformable-model-based methods that deform a shape model locally around the initialization location, we learn an image-based regressor to guide the deformable model to fit for the target ROI. Specifically, given any voxel in a new image, the image-based regressor can predict the displacement vector from this voxel towards the boundary of target ROI, which can be used to guide the deformable segmentation...
November 10, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29149706/exploring-the-impact-of-route-of-administration-on-medication-acceptance-in-hospitalized-patients-implications-for-venous-thromboembolism-prevention
#19
Victor O Popoola, Farrah Tavakoli, Brandyn D Lau, Matthew Lankiewicz, Patricia Ross, Peggy Kraus, Dauryne Shaffer, Deborah B Hobson, Jonathan K Aboagye, Norma A Farrow, Elliott R Haut, Michael B Streiff
BACKGROUND: Non-administration of venous thromboembolism (VTE) prophylaxis contributes to preventable patient harm. We hypothesized that non-administration would be more common for parenteral VTE prophylaxis than oral infectious disease or cardiac prophylaxis or for treatment medications. The primary study goal was to determine if non-administration of parenteral VTE prophylaxis is more frequent than other prophylactic or treatment medications. METHODS: In this retrospective cohort study of consecutive admissions we used descriptive statistics and risk ratios (RR) to compare the number of non-administered doses of VTE prophylaxis, oral infectious disease and cardiovascular prophylaxis and treatment medications...
October 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29149705/toll-like-receptor-4-deficiency-increases-resistance-in-sepsis-induced-immune-dysfunction
#20
Chao Cao, Yanfen Chai, Songtao Shou, Jun Wang, Ying Huang, Tao Ma
Sepsis constitutes a serious life-threatening syndrome associated with complications of deregulated inflammatory response against endotoxin/lipopolysaccharide (LPS)-mediated severe infection. Toll-like receptor 4 (TLR4) plays a critical role in the activation of innate immunity through recognition of LPS. However, the impact of TLR4 signaling on the development of sepsis-induced immune dysfunction remains unclear. The aim of this study was to investigate the effect of TLR4 on regulatory T cells (Tregs) and its potential mechanism...
November 14, 2017: International Immunopharmacology
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