Mekha A Thomas, Pooja Naik, Hong Wang, Jon T Giles, Alexander A Girgis, Seok-Young Kim, Tory P Johnson, Ashley M Curran, Jonathan D Crawford, Shaghayegh Jahanbani, Clifton O Bingham, William H Robinson, Chan Hyun Na, Erika Darrah
Although anti-citrullinated protein autoantibodies (ACPAs) are a hallmark serological feature of rheumatoid arthritis (RA), the mechanisms and cellular sources behind the generation of the RA citrullinome remain incompletely defined. Peptidylarginine deiminase IV (PAD4), one of the key enzymatic drivers of citrullination in the RA joint, is expressed by granulocytes and monocytes; however, the subcellular localization and contribution of monocyte-derived PAD4 to the generation of citrullinated autoantigens remain underexplored...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America