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https://www.readbyqxmd.com/read/28804665/management-of-traumatic-cataract-with-posterior-capsular-rupture-a-case-report-and-in-vitro-model-study
#1
Wenjuan Wan, Ke Hu, Yan Ji, Can Li
PURPOSE: To investigate the optimal strategy for surgical management of traumatic cataract with posterior capsular rupture. METHODS: We describe four cases of traumatic cataract with posterior capsular rupture and an in vitro model built to evaluate the optimal infusion pressure during surgery. RESULTS: All patients underwent cataract surgery. By using an anterior chamber maintainer to elevate infusion pressure, we safely performed cataract extraction without phacoemulsification...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28803666/-inefficacy-of-aflibercept-in-the-treatment-of-idiopathic-macular-telangiectasia-type-2%C3%A2-without-neovascularization
#2
J Bénichou, V Soler, D Denis, F Matonti
Idiopathic macular telangectasia type 2 is a rare disease consisting primarily of bilateral macular capillary telangiectasia, alterations of the ellipsoid zone and intraretinal cysts that may appear as cystoid macular edema in the absence of neovascularization. Our goal was to study the efficacy of aflibercept in the treatment of these cysts. Thus, we performed a series of three intravitreal injections of aflibercept in the right eye of a woman with a typical presentation of macular telangectasia type 2 complicated by cystoid macular edema without neovascularization...
August 10, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28803326/short-term-results-of-endovascular-surgery-with-tissue-plasminogen-activator-injection-for-central-retinal-vein-occlusion
#3
Masaaki Ishida, Shinya Abe, Takuya Nakagawa, Atsushi Hayashi
PURPOSE: To examine the effects of retinal endovascular surgery (REVS) with tissue plasminogen activator injection into the retinal vein in central retinal vein occlusion (CRVO) eyes. METHODS: Sixteen consecutive CRVO patients with macular edema and decreased visual acuity who were referred to Toyama University Hospital between March 2014 and February 2016 were included in this study. Changes in visual acuity (VA) and central retinal thickness (CRT) were evaluated up to 6 months after REVS...
August 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28801117/incidence-and-outcomes-of-infectious-and-noninfectious-endophthalmitis-after-intravitreal-injections-for-age-related-macular-degeneration
#4
Vincent Daien, Vuong Nguyen, Rohan W Essex, Nigel Morlet, Daniel Barthelmes, Mark C Gillies
PURPOSE: To assess the incidence, cumulative rate, and long-term outcomes of infectious and noninfectious endophthalmitis after intravitreal injections (IVTs) of anti-vascular endothelial growth factor (VEGF) agents. DESIGN: Database study, prospectively designed. PARTICIPANTS: Treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) tracked by the Fight Retinal Blindness! (FRB!) registry that commenced anti-VEGF therapy between January 1, 2006, and November 30, 2016...
August 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28800660/-eye-drops-instead-of-intravitreal-injections-the-dream-of-treating-macular-diseases-by-topically-administered-drugs
#5
Oliver Zeitz, Antonia M Joussen
Background The introduction of VEGF inhibitors revolutionized treatment for age-related macular degeneration. However, it requires regular intravitreal (IVT) injections. Hence, replacement of IVT injections by topical, non-invasive eye drop treatment is subject to intensive research. Material and Methods Literature and database research on topical therapies for neovascular AMD. Results Several clinical projects with topical inhibitors of the VEGF pathway were initiated recently. Several candidate molecules were investigated and should have an efficacy potential in neovascular AMD given their ability to block the VEGF pathway...
August 11, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28800629/protective-effects-on-the-retina-after-ranibizumab-treatment-in-an-ischemia-model
#6
Stephanie C Joachim, Marina Renner, Jacqueline Reinhard, Carsten Theiss, Caroline May, Stephanie Lohmann, Sabrina Reinehr, Gesa Stute, Andreas Faissner, Katrin Marcus, H Burkhard Dick
Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular occlusion. The goal of this study was to evaluate the potential protective effects of an intravitreally injected vascular endothelial growth factor (VEGF) inhibitor (ranibizumab) on retinal cells in an ischemia animal model via immunohistochemistry (IF) and quantitative real-time PCR (PCR). A positive binding of ranibizumab to rat VEGF-A was confirmed via dot blot. One eye underwent ischemia and a subgroup received ranibizumab...
2017: PloS One
https://www.readbyqxmd.com/read/28800018/the-expanding-clinical-spectrum-of-choroidal-excavation-in-macular-dystrophies
#7
Maurizio Battaglia Parodi, Giuseppe Casalino, Pierluigi Iacono, Ugo Introini, Tatevik Adamyan, Francesco Bandello
PURPOSE: To assess the prevalence and the clinical course of focal choroidal excavation (FCE) in patients affected by macular dystrophies. METHODS: Prospective case series. All the patients underwent a complete ophthalmologic examination, including best-corrected visual acuity and spectral domain optical coherence tomography. The presence of choroidal neovascularization (CNV) was assessed on the basis of the leakage detected on fluorescein angiography. RESULTS: A total of 162 eyes from 81 patients with macular dystrophy were included in the study...
August 9, 2017: Retina
https://www.readbyqxmd.com/read/28796997/dynamics-of-inflammatory-factors-in-aqueous-humor-during-ranibizumab-or-aflibercept-treatment-for-age-related-macular-degeneration
#8
Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto, Masahiko Shimura
PURPOSE: To evaluate the dynamic changes of the aqueous humor levels of inflammatory factors between patients receiving intravitreal ranibizumab injection (IRI) and aflibercept injection (IAI) in patients with exudative age-related macular degeneration (AMD). METHODS: The study was performed on 30 eyes with AMD that were scheduled to receive 3 doses of IRI (15 eyes) or IAI (15 eyes) at monthly intervals. Aqueous humor samples were collected when injection was done...
August 11, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28796148/pain-and-antisepsis-after-ocular-administration-of-povidone-iodine-versus-chlorhexidine
#9
Carmen Oakley, Penny Allen, Joobin Hooshmand, Brendan J T Vote
PURPOSE: To investigate ocular bacterial count before and after antisepsis with aqueous chlorhexidine (AC) or povidone-iodine (PI) and to assess discomfort with each agent. METHODS: Bacterial swabs were taken from participants' eyes before and after antisepsis. These underwent microscopy, culture, and sensitivity testing. Aqueous chlorhexidine drops were administered to left eyes and PI to right eyes. Participants rated their pain (scale 0-10) for each eye but were blinded to the type of drop...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28796143/treatment-patterns-and-2-year-vision-outcomes-with-bevacizumab-in-diabetic-macular-edema-an-analysis-from-a-large-u-s-integrated-health-care-system
#10
Donald S Fong, Tiffany Q Luong, Richard Contreras, Jennifer J Jimenez, Peter H Custis, Vaishali Patel, Joanna H Campbell
PURPOSE: To assess health care utilization and vision outcomes over 2 years in patients receiving bevacizumab treatment in clinical practice for diabetic macular edema. METHODS: Patients with newly diagnosed diabetic macular edema who received an intravitreal bevacizumab injection within 12 months of initial diagnosis were identified from Kaiser Permanente's 350,000 patients with diabetes mellitus treated between 2008 and 2013. Snellen best-corrected visual acuity (BCVA), number of intravitreal injections, and patient characteristics were abstracted from the electronic record...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28794900/structure-versus-function-correlation-between-outer-retinal-and-choroidal-thicknesses-measured-by-swept-source-oct-with-multifocal-electroretinography-and-visual-acuity
#11
Ignacio Flores-Moreno, Luis Arias-Barquet, Marcos J Rubio-Caso, Alex Muñoz-Blanco, María Vidal-Martí, Jaume Catala-Mora, José M Ruiz-Moreno, Jay S Duker, Josep M Caminal
BACKGROUND: To correlate retina-choroidal anatomy as assessed via swept-source OCT (SS-OCT) with retinal function as determined by best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG). METHODS: Thirty-three eyes from 33 patients including 16 with neovascular AMD (nvAMD) and 17 controls were included. Patients were included in the present study after a complete ophthalmologic examination, including BCVA, slit-lamp study, intraocular pressure measurement, dilated fundus examination after tropicamide instillation, SD-OCT, SS-OCT, fundus photographs and mfERG...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28790804/treatment-of-myopic-choroidal-neovascularization-with-intravitreal-ranibizumab-injections-the-role-of-age
#12
Dimitrios Karagiannis, Georgios A Kontadakis, Konstantinos Kaprinis, Athanassios Giarmoukakis, Ilias Georgalas, Efstratios A Parikakis, Miltiadis K Tsilimbaris
PURPOSE: The aim of this study was to explore the role of age as a prognostic factor for the outcome of myopic choroidal neovascularization (CNV) treatment with intravitreal ranibizumab injections. METHODS: A retrospective review of charts of patients treated with intravitreal injections of ranibizumab for the treatment of myopic CNV was done. Patients with other ophthalmic disease were excluded. Patients were followed for at least 2 years. The correlation between age and the change in visual acuity and the number of injections during treatment was investigated...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28790803/the-outcome-of-low-frequency-intravitreal-bevacizumab-therapy-for-macular-edema-in-retinal-vein-occlusions
#13
Biljana Ivanovska Adjievska, Salih Boskurt, Nikola Orovcanec, Vesna Dimovska-Jordanova
AIM: We aimed to evaluate the 1-year efficacy and safety of low-frequency intravitreal bevacizumab in the treatment of macular edema due to retinal vein occlusions (RVOs). METHODS: The study comprised an interventional prospective study of patients with macular edema due to central retinal vein occlusion (CRVO) or branch retinal vein occlusion, followed for 12 months. Treatment-naïve patients with reduced best-corrected visual acuity (BCVA) and central macular thickness (CMT) of at least 250 μm received intravitreal injection of bevacizumab...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28776095/treatment-of-age-related-neovascular-macular-degeneration-the-patient-s-perspective
#14
S Müller, C Ehlken, U Bauer-Steinhusen, W Lechtenfeld, Z Hasanbasic, H Agostini, T Wilke
OBJECTIVES: The aim of this study was to assess patients' views and expectations with regard to neovascular age-related macular degeneration (nAMD) and intravitreal anti-VEGF therapy (IVT). METHODS: We conducted a multicenter, non-interventional, prospective cohort study including nAMD patients treated with IVT in Germany. Patients with at least one IVT before study enrollment and aged ≥50 years were included. Three telephone interviews were conducted during a 12-month observational period...
August 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28775088/bilateral-choroidal-neovascular-membrane-in-a-young-patient-with-sorsby-fundus-dystrophy-the-value-of-prompt-treatment
#15
Nardine Menassa, Sreekala Burgula, Theodoros Empeslidis, Konstantinos T Tsaousis
A 45-year-old man had developed a choroidal neovascular membrane (CNVM) in his left eye at the age of 38 years and had received six intravitreal ranibizumab injections with resulting visual acuities of 6/60 in the affected eye and 6/4 in the unaffected right eye (Snellen charts). Family history and genetic testing revealed tissue inhibitor of metalloproteinase-3 (TIMP3) gene positive Sorsby fundus dystrophy (SFD). The patient has been under regular follow-up since. At the age of 45 years, he presented with subretinal fluid accumulation in his right eye suggestive of CNVM and received six intravitreal ranibizumab injections, which maintained visual acuity of 6/7...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28774322/tau-accumulation-in-the-retina-promotes-early-neuronal-dysfunction-and-precedes-brain-pathology-in-a-mouse-model-of-alzheimer-s-disease
#16
Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo
BACKGROUND: Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer's disease (AD), pathological tau accumulation correlates with cognitive decline. Substantial visual deficits are found in individuals affected by AD including a preferential loss of retinal ganglion cells (RGCs), the neurons that convey visual information from the retina to the brain. At present, however, the mechanisms that underlie vision changes in these patients are poorly understood...
August 3, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28770109/ocular-adverse-effects-of-intravitreal-bevacizumab-are-potentiated-by-intermittent-hypoxia-in-a-rat-model-of-oxygen-induced-retinopathy
#17
Jeffrey J Tan, Charles L Cai, Eric M Shrier, Lois McNally, Douglas R Lazzaro, Jacob V Aranda, Kay D Beharry
Intravitreal bevacizumab (Avastin) use in preterm infants with retinopathy of prematurity is associated with severe neurological disabilities, suggesting vascular leakage. We examined the hypothesis that intermittent hypoxia (IH) potentiates intravitreal Avastin leakage. Neonatal rats at birth were exposed to IH from birth (P0)-P14. At P14, the time of eye opening in rats, a single dose of Avastin (0.125 mg) was injected intravitreally into the left eye. Animals were placed in room air (RA) until P23 or P45 for recovery (IHR)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28769551/intravitreal-aflibercept-for-choroidal-neovascularization-associated-with-chorioretinitis-a-pilot-study
#18
Andrii R Korol, Oleksandra Zborovska, Taras Kustryn, Oleksandra Dorokhova, Nataliya Pasyechnikova
PURPOSE: The purpose of this study was to evaluate the potential benefits of intravitreal aflibercept injections for the treatment of choroidal neovascularization (CNV) secondary to chorioretinitis. METHODS: In this uncontrolled, prospective cohort study, 15 eyes of 14 consecutive patients affected by CNV associated with ocular toxoplasmosis were treated with intravitreal aflibercept (2 mg) pro re nata and observed over a 12-month follow-up period. The primary outcome was the change in best-corrected visual acuity (BCVA) from baseline to month 12...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28767729/protective-effect-of-clusterin-on-rod-photoreceptor-in-rat-model-of-retinitis-pigmentosa
#19
Andrew Vargas, Hwa Sun Kim, Erika Baral, Wan-Qing Yu, Cheryl Mae Craft, Eun-Jin Lee
Retinitis Pigmentosa (RP) begins with the death of rod photoreceptors and is slowly followed by a gradual loss of cones and a rearrangement of the remaining retinal neurons. Clusterin is a chaperone protein that protects cells and is involved in various pathophysiological stresses, including retinal degeneration. Using a well-established transgenic rat model of RP (rhodopsin S334ter), we investigated the effects of clusterin on rod photoreceptor survival. To investigate the role of clusterin in S334ter-line3 retinas, Voronoi analysis and immunohistochemistry were used to evaluate the geometry of rod distribution...
2017: PloS One
https://www.readbyqxmd.com/read/28767552/efficacy-and-frequency-of-intravitreal-aflibercept-versus-bevacizumab-for-macular-edema-secondary-to-central-retinal-vein-occlusion
#20
Ayman Lotfy, Kamal A M Solaiman, Ayman Abdelrahman, Ahmed Samir
PURPOSE: To compare the safety, efficacy, and frequency of intravitreal injection of aflibercept and bevacizumab for treatment of macular edema secondary to central retinal vein occlusion. DESIGN: Prospective, comparative, randomized, interventional study. PATIENTS AND METHODS: Eyes with macular edema secondary to central retinal vein occlusion were randomized between two groups according to the intravitreal injection used. Group A included eyes treated with intravitreal aflibercept, and Group B included eyes treated with intravitreal bevacizumab injections...
August 1, 2017: Retina
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