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Prenatal depression

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https://www.readbyqxmd.com/read/29035309/serum-magnesium-levels-in-preterm-infants-are-higher-than-adult-levels-a-systematic-literature-review-and-meta-analysis
#1
REVIEW
Jacques Rigo, Catherine Pieltain, Viola Christmann, Francesco Bonsante, Sissel J Moltu, Silvia Iacobelli, Stéphane Marret
Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal period and to highlight the factors influencing Mg levels and the importance of regulating sMg levels during pregnancy and birth...
October 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29032226/maternal-depressive-symptoms-linked-to-reduced-fecal-immunoglobulin-a-concentrations-in-infants
#2
Liane J Kang, Petya T Koleva, Catherine J Field, Gerald F Giesbrecht, Eytan Wine, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Anita L Kozyrskyj
Secretory Immunoglobulin A (sIgA) plays a critical role to infant gut mucosal immunity. Delayed IgA production is associated with greater risk of allergic disease. Murine models of stressful events during pregnancy and infancy show alterations in gut immunity and microbial composition in offspring, but little is known about the stress-microbiome-immunity pathways in humans. We investigated differences in infant fecal sIgA concentrations according to the presence of maternal depressive symptoms during and after pregnancy...
October 11, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29019029/hippocampal-acetylation-may-improve-prenatal-stress-induced-depression-like-behavior-of-male-offspring-rats-through-regulating-ampars-expression
#3
Yong Lu, Junli Zhang, Lin Zhang, Shaokang Dang, Qian Su, Huiping Zhang, Tianwei Lin, Xiaoxiao Zhang, Yurong Zhang, Hongli Sun, Zhongliang Zhu, Hui Li
This study is to determine the role and mechanism of hippocampal acetylation in prenatal stress (PS) induced depression-like behavior of male offspring rats. PS-induced depression rat model was established. Sucrose preference and forced swim test were used to observe the behavior changes of male offspring rats. Hippocampal acetylation was induced by Trichostatin A injection. Quantitative real-time PCR and Western blot were used to determine the changes of AMPARs in acetylated hippocampus. The behavioral tests proved that AMPA was involved in the PS-induced depression-like behavior in offspring rats...
October 10, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28992958/positive-childhood-experiences-predict-less-psychopathology-and-stress-in-pregnant-women-with-childhood-adversity-a-pilot-study-of-the-benevolent-childhood-experiences-bces-scale
#4
Angela J Narayan, Luisa M Rivera, Rosemary E Bernstein, William W Harris, Alicia F Lieberman
This pilot study examined the psychometric properties of the Benevolent Childhood Experiences (BCEs) scale, a new instrument designed to assess positive early life experiences in adults with histories of childhood maltreatment and other adversities. A counterpart to the Adverse Childhood Experiences (ACEs) questionnaire, the BCEs was developed to be multiculturally-sensitive and applicable regardless of socioeconomic position, urban-rural background, or immigration status. Higher levels of BCEs were hypothesized to predict lower levels of psychopathology and stress beyond the effects of ACES in a sample of ethnically diverse, low-income pregnant women...
October 6, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28992584/ogt-related-mitochondrial-motility-is-associated-with-sex-differences-and-exercise-effects-in-depression-induced-by-prenatal-exposure-to-glucocorticoids
#5
Weina Liu, Hongmei Wang, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi, Liu Ji
BACKGROUND: Prenatal exposure to glucocorticoids (GCs) has been found to trigger abnormal behaviors and deleterious neurological effects on offspring both in animals and in humans. The sex differences in depression have been replicated in numerous studies across cultures, persisting throughout the reproductive years. As an X-linked gene in rodents and in humans, O-GlcNAc transferase (OGT) may provide a novel perspective for the sex differences in depression. METHODS: In the last third of pregnancy (gestational day 14-21), rats were subcutaneously administered either 0...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28987984/examining-pathways-linking-maternal-depressive-symptoms-in-infancy-to-children-s-behavior-problems-the-role-of-maternal-unresponsiveness-and-negative-behaviors
#6
Pamela Linton Norcross, Esther M Leerkes, Nan Zhou
The extent to which maternal depressive symptoms in the first 6 months of life is linked with internalizing and externalizing behaviors in childhood through specific insensitive maternal behaviors (unresponsive and overtly negative behaviors) was examined in a sample of 259 mother-infant dyads. In addition, the extent to which these paths were moderated by infant negative emotionality was also examined. Maternal depressive symptoms were assessed prenatally and when infants were 6 months and 2 years old. Maternal unresponsive and overtly negative behaviors and infant negative emotionality were observed when infants were 6 months old...
October 5, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28986652/infant-development-and-pre-and-post-partum-depression-in-rural-south-african-hiv-infected-women
#7
Violeta J Rodriguez, Gladys Matseke, Ryan Cook, Seanna Bellinger, Stephen M Weiss, Maria L Alcaide, Karl Peltzer, Doyle Patton, Maria Lopez, Deborah L Jones
HIV-exposed infants born to depressed women may be at risk for adverse developmental outcomes. Half of HIV-infected women in rural South Africa (SA) may suffer from pregnancy-related depression. This pilot study examined the impact of depression in HIV-infected women in rural SA on infant development. Mother-infant dyads (N = 69) were recruited in rural SA. Demographics, HIV disclosure, depression, male involvement, and alcohol use at baseline (18.35 ± 5.47 weeks gestation) were assessed. Male involvement, depression, infant HIV serostatus and development were assessed 12 months postnatally...
October 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28975539/exposure-to-hypertensive-disorders-of-pregnancy-increases-the-risk-of-autism-spectrum-disorder-in-affected-offspring
#8
Eileen A Curran, Gerard W O'Keeffe, Ann Marie Looney, Gerard Moloney, Shane V Hegarty, Deirdre M Murray, Ali S Khashan, Louise C Kenny
There is growing awareness that prenatal adversity may increase the risk of autism spectrum disorder (ASD). Here, we examined the association between hypertensive disorders of pregnancy (HDP) and ASD risk at 7 years of age using the Millennium Cohort Study (MCS), a representative cohort of 13,192 children born in the UK from 2000 to 2001. We also sought to examine cytokine expression in the serum of women with pre-eclampsia, which is the most common HDP, and whether exposure of foetal neurons to this serum could change patterns of neuronal growth...
October 3, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28975443/prenatal-life-events-maternal-employment-and-postpartum-depression-across-a-diverse-population-in-new-york-city
#9
Cindy H Liu, Jenny Phan, Miwa Yasui, Stacey Doan
This study examined racial/ethnic disparities in three core postpartum depression (PPD) symptoms, and identified specific predictors of PPD including sociodemographic variables, life stressors and maternal employment. White, African American, Hispanic, and Asian/Pacific Islander women from the New York City area (n = 3010) completed the 2009-2011 Pregnancy Risk Assessment Monitoring System. African American women were less likely to have PPD than White women. Maternal employment during the postpartum was associated with an increased likelihood of PPD for White women relative to women who were not employed...
October 3, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28974783/environmental-perturbation-of-the-circadian-clock-during-pregnancy-leads-to-transgenerational-mood-disorder-like-behaviors-in-mice
#10
Peng Zhang, Guang Li, Hui Li, XiaoQiu Tan, Hai-Ying Mary Cheng
It remains unknown whether chronic circadian disturbance (CCD) during pregnancy can lead to mood disorders in the offspring. Here we show that pregnant mice in the F0 generation that were exposed to CCD stress displayed depression-like behaviors, and produced offspring in the F1 and F2 generations that also exhibited mood-associated behavioral phenotypes despite the lack of direct stressful experiences during their postnatal or adult period. Prenatal CCD stress was correlated with the elevation of plasma corticosterone levels in F1 mice...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28973846/bupropion-use-during-pregnancy-a-systematic-review
#11
Victoria Hendrick, Rita Suri, Michael J Gitlin, Elena Ortiz-Portillo
Objective: To evaluate data on birth outcomes following bupropion use during pregnancy. Data Sources: A systematic literature review of PubMed and PsycINFO was performed through June 2017 for clinical studies published in English. The following keywords were used: bupropion, pregnancy, depression, smoking cessation, birth outcomes, miscarriage, and spontaneous abortion. References and related articles were also searched to yield additional publications. With the exception of limiting the search to human subjects, no other limitations were applied in an effort to capture all relevant published studies...
September 21, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28962922/treadmill-exercise-alleviated-prenatal-buprenorphine-exposure-induced-depression-in-rats
#12
Chih-Cheng Wu, Chih-Jen Hung, Shih-Yi Lin, Ya-Yu Wang, Cheng-Yi Chang, Wen-Ying Chen, Su-Lan Liao, Shue-Ling Raung, Ching-Ping Yang, Chun-Jung Chen
Mounting evidence suggests that physical exercise shows health benefits in a range of diseases, including psychiatric disorders. Perinatal opioid exposure produces neurobehavioral abnormality, which includes depression symptoms, in patients and their offspring following chronic use of buprenorphine, a mixed agonist/antagonist with a high affinity to opioid receptors, for pain control. Previously, we demonstrated that prenatal buprenorphine exposure in pregnant Sprague-Dawley rats starting from gestation day 7 and lasting for 14 days caused the development of depression-like phenotypes in pups at postnatal day 21...
September 27, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28959195/prenatal-exposure-to-paint-thinner-alters-postnatal-development-and-behavior-in-mice
#13
Hanaa Malloul, Ferdaousse M Mahdani, Mohammed Bennis, Saadia Ba-M'hamed
Occupational exposure and sniffing of volatile organic solvents continue to be a worldwide health problem, raising the risk for teratogenic sequelae of maternal inhalant abuse. Real life exposures usually involve simultaneous exposures to multiple solvents, and almost all the abused solvents contain a mixture of two or more different volatile compounds. However, several studies examined the teratogenicity due to industrial exposure to a single volatile solvent but investigating the teratogenic potential of complex chemical mixture such as thinner remains unexplored...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28956168/continuity-of-midwifery-carer-moderates-the-effects-of-prenatal-maternal-stress-on-postnatal-maternal-wellbeing-the-queensland-flood-study
#14
Sue Kildea, Gabrielle Simcock, Aihua Liu, Guillaume Elgbeili, David P Laplante, Adele Kahler, Marie-Paule Austin, Sally Tracy, Sue Kruske, Mark Tracy, Michael W O'Hara, Suzanne King
Poor postnatal mental health is a major public health issue, and risk factors include experiencing adverse life events during pregnancy. We assessed whether midwifery group practice, compared to standard hospital care, would protect women from the negative impact of a sudden-onset flood on postnatal depression and anxiety. Women either received midwifery group practice care in pregnancy, in which they were allocated a primary midwife who provided continuity of care, or they received standard hospital care provided by various on-call and rostered medical staff...
September 27, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28947110/genetic-testing-for-huntington-disease
#15
Kimberly A Quaid
In 1983, Huntington disease (HD) became the first disease to be mapped to a previously unknown location on chromosome 4. This discovery meant that we could now identify whether some individuals at risk for HD would develop HD in the future using a method called linkage testing. Testing was first offered through research protocols designed to assess whether testing could be done safely in this population. Testing guidelines were soon developed by the Huntington's Disease Society of America and the International Huntington Association in collaboration with the World Federation of Neurology...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28945932/attention-deficit-hyperactivity-disorder-symptom-clusters-differentially-predict-prenatal-health-behaviors-in-pregnant-women
#16
Heather A Jones, Laura D Eddy, Annie E Rabinovitch, Daniel J Snipes, Stephanie A Wilson, Amanda M Parks, Nicole W Karjane, Dace S Svikis
OBJECTIVE: To date, most investigations of mental health in pregnant women have focused on depression or substance use. This study aimed to (a) delineate the relationships between symptoms of attention-deficit/hyperactivity disorder (ADHD) and prenatal health behaviors and (b) explore whether the symptom clusters of ADHD differentially predict prenatal health behaviors (e.g., physical strain, healthy eating, prenatal vitamin use). METHOD: A total of 198 pregnant women (mean age = 27...
September 25, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28941769/a-neuro-immune-neuro-oxidative-and-neuro-nitrosative-model-of-prenatal-and-postpartum-depression
#17
REVIEW
Chutima Roomruangwong, George Anderson, Michael Berk, Drozdstoy Stoyanov, André F Carvalho, Michael Maes
A large body of evidence indicates that major affective disorders are accompanied by activated neuro-immune, neuro-oxidative and neuro-nitrosative stress (IO&NS) pathways. Postpartum depression is predicted by end of term prenatal depressive symptoms whilst a lifetime history of mood disorders appears to increase the risk for both prenatal and postpartum depression. This review provides a critical appraisal of available evidence linking IO&NS pathways to prenatal and postpartum depression. The electronic databases Google Scholar, PubMed and Scopus were sources for this narrative review focusing on keywords, including perinatal depression, (auto)immune, inflammation, oxidative, nitric oxide, nitrosative, tryptophan catabolites (TRYCATs), kynurenine, leaky gut and microbiome...
September 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28939248/early-life-home-environment-and-risk-of-asthma-among-inner-city-children
#18
George T O'Connor, Susan V Lynch, Gordon R Bloomberg, Meyer Kattan, Robert A Wood, Peter J Gergen, Katy F Jaffee, Agustin Calatroni, Leonard B Bacharier, Avrahman Beigelman, Megan T Sandel, Christine C Johnson, Ali Faruqi, Clark Santee, Kei E Fujimura, Douglas Fadrosh, Homer Boushey, Cynthia M Visness, James E Gern
BACKGROUND: Environmental exposures in early life appear to play an important role in the pathogenesis of childhood asthma, but the potentially modifiable exposures that lead to asthma remain uncertain. OBJECTIVE: We sought to identify early-life environmental risk factors for childhood asthma in a birth cohort of high-risk inner-city children. METHODS: We examined the relationship of prenatal and early-life environmental factors to the occurrence of asthma at 7 years of age among 442 children...
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28936028/social-support-and-postpartum-depression-revisited-the-traditional-female-role-as-moderator-among-mexican-women
#19
Analia F Albuja, M Asunción Lara, Laura Navarrete, Lourdes Nieto
Women who lack social support tend to have a higher risk of postpartum depression. The present study examined the traditional female role, understood here as the adoption of passive and submissive traits specific to Mexican women, as another risk factor for postpartum depressive symptomatology that interacts with social support. Using two waves of data from a longitudinal study of 210 adult Mexican women (20-44 years-old, Mage = 29.50 years, SD = 6.34), we found that lacking social support during the third trimester of their pregnancy was associated with greater depressive symptoms at 6 months in the postpartum, although this relationship depended on the level of endorsement of the traditional female role during pregnancy...
August 2017: Sex Roles
https://www.readbyqxmd.com/read/28918249/perinatal-depression-and-dna-methylation-of-oxytocin-related-genes-a-study-of-mothers-and-their-children
#20
Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 19, 2017: Hormones and Behavior
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