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Prenatal anxiety

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https://www.readbyqxmd.com/read/27899401/neonatal-and-childhood-neurodevelopmental-health-and-educational-outcomes-of-children-exposed-to-antidepressants-and-maternal-depression-during-pregnancy-protocol-for-a-retrospective-population-based-cohort-study-using-linked-administrative-data
#1
Deepa Singal, Marni Brownell, Dan Chateau, Chelsea Ruth, Laurence Y Katz
INTRODUCTION: Antidepressants are commonly prescribed during pregnancy; however, there are inconsistent data on the safety of these medications during the prenatal period. To address this gap, this study will investigate short-term and long-term neurodevelopmental, physical and mental health, and educational outcomes of children who have been exposed to selective serotonin reuptake inhibitors (SSRIs) or selective serotonin norepinephrine reuptake inhibitors (SNRIs) and/or maternal depression during pregnancy...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27896246/quantitative-fluorescent-polymerase-chain-reaction-for-rapid-prenatal-diagnosis-of-fetal-aneuploidies-in-chorionic-villus-sampling-in-a-single-institution
#2
You Jung Shin, Jin Hoon Chung, Do Jin Kim, Hyun Mee Ryu, Moon Young Kim, Jung Yeol Han, June Seek Choi
OBJECTIVE: To validate quantitative fluorescent polymerase chain reaction (QF-PCR) via chorionic villus sampling (CVS) for the diagnosis of fetal aneuploidies. METHODS: We retrospectively reviewed the medical records of consecutive pregnant women who had undergone CVS at Cheil General Hospital between December 2009 and June 2014. Only cases with reported QF-PCR before long-term culture (LTC) for conventional cytogenetic analysis were included, and the results of these two methods were compared...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27883060/environmental-intervention-as-a-therapy-for-adverse-programming-by-ancestral-stress
#3
J Keiko McCreary, Zachary T Erickson, YongXin Hao, Yaroslav Ilnytskyy, Igor Kovalchuk, Gerlinde A S Metz
Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerationally heritable endocrine and epigenetic footprint and elevated stress sensitivity which can be alleviated by beneficial experiences in later life. Ancestral stress led to downregulated glucocorticoid receptor and prefrontal cortex neuronal densities along with precocious development of anxiety-like behaviours...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27862072/views-of-american-ob-gyns-on-the-ethics-of-prenatal-whole-genome-sequencing
#4
Michelle J Bayefsky, Amina White, Paul Wakim, Sara Chandros Hull, David Wasserman, Stephanie Chen, Benjamin E Berkman
OBJECTIVE: Given public demand for genetic information, the potential to perform prenatal whole-genome sequencing (PWGS) non-invasively in the future, and decreasing costs of whole-genome sequencing, it is likely that OB/GYN practice will include PWGS. The goal of this project was to explore OB/GYNs' views on the ethical issues surrounding PWGS and their preparedness for counseling patients on its use. METHODS: A national survey was administered to 2500 members of American Congress of Obstetricians and Gynecologists...
November 16, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27844025/prenatal-deletion-of-dna-methyltransferase-1-in-neural-stem-cells-impairs-neurogenesis-and-causes-anxiety-like-behavior-in-adulthood
#5
Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Masakazu Namihira, Kinichi Nakashima
Despite recent advances in our understanding of epigenetic regulation of central nervous system development, little is known regarding the effects of epigenetic dysregulation on neurogenesis and brain function in adulthood. In the present study, we show that prenatal deletion of DNA methyltransferase 1 (Dnmt1) in neural stem cells results in impaired neurogenesis as well as increases in inflammatory features (e.g., elevated glial fibrillary acidic protein [GFAP] expression in astrocytes and increased numbers of microglia) in the adult mouse brain...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27837574/there-is-no-safe-threshold-for-lead-exposure-%C3%AE-literature-review
#6
Th Vorvolakos, S Arseniou, M Samakouri
: Lead was one of the most dangerous environmental toxic substances for a long time in western countries, and this is still the case for many places on earth today. Its neurotoxic potential is highly significant but its secure blood level concentration remains unknown. The aim of this study was to approach the above issue from the perspective of social psychiatry. A systematic search was made of Dialog and Datastar interfaces for data regarding the neuropsychiatric complications of direct or chronic exposure to lead, and a review of the relevant literature was conducted using the databases Medline, Embase, CAB Global Health and Cochrane...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27835662/marijuana-use-is-associated-with-behavioral-approach-and-depressive-symptoms-in-adolescents-and-emerging-adults
#7
Natasha E Wright, Danny Scerpella, Krista M Lisdahl
BACKGROUND: Repeated CB1 binding due to THC results in downregulation of the endocannabinoid system in cortex and limbic regions, perhaps disrupting frontolimbic functioning. This is particularly a concern in young adults who are still undergoing neurodevelopment in frontal and limbic regions. Such disruptions may be linked to increased depressive symptoms, anxiety symptoms, and executive dysfunction, and decreased behavioral approach. OBJECTIVES: Here we examine the influence of young adult marijuana use on anxiety, depressive symptoms, behavioral approach, and executive dysfunction...
2016: PloS One
https://www.readbyqxmd.com/read/27818729/maternal-nicotine-exposure-during-late-gestation-and-lactation-increases-anxiety-like-and-impulsive-decision-making-behavior-in-adolescent-offspring-of-rat
#8
Hyunchan Lee, Sooyeon Chung, Jihyun Noh
Prenatal nicotine exposure over an entire pregnancy has been associated with an increased prevalence of hyperactivity, anxiety-like behavior and depression-like behavior in mature rats. However, the effects of maternal nicotine exposure in late gestation and lactation on the psychology and behavior of adolescent rat offspring are unclear. Thus, we investigated the effect of nicotine exposure during late gestation and lactation on anxiety-like and impulsive decision-making behavior in adolescent offspring of rat...
October 2016: Toxicological Research
https://www.readbyqxmd.com/read/27812327/social-preference-deficits-in-juvenile-zebrafish-induced-by-early-chronic-exposure-to-sodium-valproate
#9
Xiuyun Liu, Yinglan Zhang, Jia Lin, Qiaoxi Xia, Ning Guo, Qiang Li
Prenatal exposure to sodium valproate (VPA), a widely used anti-epileptic drug, is related to a series of dysfunctions, such as deficits in language and communication. Clinical and animal studies have indicated that the effects of VPA are related to the concentration and to the exposure window, while the neurobehavioral effects of VPA have received limited research attention. In the current study, to analyze the neurobehavioral effects of VPA, zebrafish at 24 h post-fertilization (hpf) were treated with early chronic exposure to 20 μM VPA for 7 h per day for 6 days or with early acute exposure to 100 μM VPA for 7 h...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27801949/maternal-prenatal-stress-and-child-atopic-dermatitis-up-to-age-2-years-the-ulm-spatz-health-study
#10
Stefanie Braig, Johannes M Weiss, Tobias Stalder, Clemens Kirschbaum, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Evidence linking maternal psychosocial stress during pregnancy to subsequent child atopic dermatitis (AD) is growing but the definition of AD is diverse and results are inconsistent. We aimed to analyze the relationship between stress and AD using alternative methods of measurement of stress and AD. METHODS: In the Ulm SPATZ Health Study, chronic stress and symptoms of anxiety and depression were assessed by standardized self-reported questionnaires in 934 mothers of singletons following delivery in Ulm, Germany, from 04/2012-05/2013...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27787386/comparison-of-group-cognitive-behavioral-therapy-and-interactive-lectures-in-reducing-anxiety-during-pregnancy-a-quasi-experimental-trial
#11
Fariba Salehi, Mehdi Pourasghar, Alireza Khalilian, Zohreh Shahhosseini
BACKGROUND: Anxiety during pregnancy and its adverse effects on mother and baby is a health concern worldwide. This study aimed to investigate the effects of group cognitive behavioral therapy (GCBT) compared with interactive lectures (IL) on anxiety during pregnancy. METHODS: This quasi experimental trial was conducted in Sari city, in north Iran, from March to July 2015. Participants were 91 obstetrically and medically low-risk nulliparous women with a mild to moderate anxiety level, as assessed by Spielberger's State-Trait Anxiety Inventory...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27780654/acculturative-stress-is-associated-with-trajectory-of-anxiety-symptoms-during-pregnancy-in-mexican-american-women
#12
Andrea Preciado, Kimberly D'Anna-Hernandez
Over half of pregnant women report anxiety symptoms and these symptoms may be precipitated by stressful experiences. Anxiety rates may be higher in Mexican-American women who experience sociocultural stressors, such as acculturation, acculturative stress and discrimination. However, the role of such stressors on the trajectory of anxiety symptoms across pregnancy is not yet known. Mexican-American women (n=151) completed surveys across pregnancy about acculturation, acculturative stress, perceived discrimination, and state anxiety...
October 7, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27776561/prenatal-exposure-to-very-severe-maternal-obesity-is-associated-with-adverse-neuropsychiatric-outcomes-in-children
#13
T H Mina, M Lahti, A J Drake, K Räikkönen, H Minnis, F C Denison, J E Norman, R M Reynolds
BACKGROUND: Prenatal maternal obesity has been linked to adverse childhood neuropsychiatric outcomes, including increased symptoms of attention deficit hyperactivity disorder (ADHD), internalizing and externalizing problems, affective disorders and neurodevelopmental problems but few studies have studied neuropsychiatric outcomes among offspring born to very severely obese women or assessed potential familial confounding by maternal psychological distress. METHOD: We evaluated neuropsychiatric symptoms in 112 children aged 3-5 years whose mothers had participated in a longitudinal study of obesity in pregnancy (50 very severe obesity, BMI ⩾40 kg/m2, obese class III and 62 lean, BMI 18...
October 25, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27764701/prenatal-paraquat-exposure-induces-neurobehavioral-and-cognitive-changes-in-mice-offspring
#14
Yassine Ait-Bali, Saadia Ba-M'hamed, Mohammed Bennis
In the present work, we investigated developmental toxicity of Paraquat (PQ), from the 1st or 6th day of mating and throughout the gestation period. We have examined several parameters, including toxicity indices, reproductive performance, sensorimotor development, as well as anxiety and cognitive performance of the offspring. Our results showed that exposure to 20mg/kg of Paraquat during the first days of pregnancy completely prevents pregnancy in treated mice, but from the 6th day of pregnancy, an alteration in fertility and reproductive parameters was observed...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27761915/respiratory-sinus-arrhythmia-moderates-the-impact-of-maternal-prenatal-anxiety-on-infant-negative-affectivity
#15
Mikko J Peltola, Tiina Mäkelä, E Juulia Paavonen, Elina Vierikko, Outi Saarenpää-Heikkilä, Tiina Paunio, Jari K Hietanen, Anneli Kylliäinen
Maternal prenatal anxiety is associated with infants' temperamental negative affectivity (NA), but it is unclear to what extent children vary in their susceptibility to prenatal influences. We tested a hypothesis that infants' respiratory sinus arrhythmia (RSA), an index of parasympathetic vagal tone and a potential marker of differential susceptibility to environmental influences, moderates the effects of maternal prenatal anxiety on the development of infant NA. Prenatal anxiety was assessed during the last trimester of pregnancy in a low-risk community sample...
October 20, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27752485/the-effect-of-mindfulness-integrated-cognitive-behavior-therapy-on-depression-and-anxiety-among-pregnant-women-a-randomized-clinical-trial
#16
Reza Yazdanimehr, Abdollah Omidi, Zohreh Sadat, Hossein Akbari
Introduction: Pregnancy can be associated with different psychological problems such as depression and anxiety. These problems are often neglected and left untreated. This study aimed to examine the effect of mindfulness-integrated cognitive behavior therapy on depression and anxiety among pregnant women. Methods: A convenient sample of 80 pregnant women were selected. Participants were randomly allocated to either the experimental or the control groups. Participants in the experimental group received mindfulness-integrated cognitive behavior therapy while women in the control group only received routine prenatal care services...
September 2016: Journal of Caring Sciences
https://www.readbyqxmd.com/read/27739584/trial-by-dutch-laboratories-for-evaluation-of-non-invasive-prenatal-testing-part-ii-women-s-perspectives
#17
Rachel V van Schendel, Lieve Page-Christiaens, Lean Beulen, Catia M Bilardo, Marjon A de Boer, Audrey B C Coumans, Brigitte H Faas, Irene M van Langen, Klaske D Lichtenbelt, Merel C van Maarle, Merryn V E Macville, Dick Oepkes, Eva Pajkrt, Lidewij Henneman
OBJECTIVE: To evaluate preferences and decision-making amongst high-risk pregnant women offered a choice between Non-Invasive Prenatal Testing (NIPT), invasive testing or no further testing. METHODS: Nationwide implementation study (TRIDENT) offering NIPT as contingent screening test for women at increased risk for fetal aneuploidy based on first-trimester combined testing (>1:200) or medical history. A questionnaire was completed after counseling assessing knowledge, attitudes and participation following the Multidimensional Measure of Informed Choice...
October 14, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27725661/adenosine-a2a-receptor-regulation-of-microglia-morphological-remodeling-gender-bias-in-physiology-and-in-a-model-of-chronic-anxiety
#18
L Caetano, H Pinheiro, P Patrício, A Mateus-Pinheiro, N D Alves, B Coimbra, F I Baptista, S N Henriques, C Cunha, A R Santos, S G Ferreira, V M Sardinha, J F Oliveira, A F Ambrósio, N Sousa, R A Cunha, A J Rodrigues, L Pinto, C A Gomes
Developmental risk factors, such as the exposure to stress or high levels of glucocorticoids (GCs), may contribute to the pathogenesis of anxiety disorders. The immunomodulatory role of GCs and the immunological fingerprint found in animals prenatally exposed to GCs point towards an interplay between the immune and the nervous systems in the etiology of these disorders. Microglia are immune cells of the brain, responsive to GCs and morphologically altered in stress-related disorders. These cells are regulated by adenosine A2A receptors, which are also involved in the pathophysiology of anxiety...
October 11, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27708559/does-prenatal-valproate-interact-with-a-genetic-reduction-in-the-serotonin-transporter-a-rat-study-on-anxiety-and-cognition
#19
Bart A Ellenbroek, Caren August, Jiun Youn
There is ample evidence that prenatal exposure to valproate (or valproic acid, VPA) enhances the risk of developing Autism Spectrum Disorders (ASD). In line with this, a single injection of VPA induces a multitude of ASD-like symptoms in animals, such as rats and mice. However, there is equally strong evidence that genetic factors contribute significantly to the risk of ASD and indeed, like most other psychiatric disorders, ASD is now generally thought to results from an interaction between genetic and environmental factors...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27699637/cytokine-profile-and-maternal-depression-and-anxiety-symptoms-in-mid-pregnancy-the-finnbrain-birth-cohort-study
#20
Linnea Karlsson, Niko Nousiainen, Noora M Scheinin, Mikael Maksimow, Marko Salmi, Soili M Lehto, Mimmi Tolvanen, Heikki Lukkarinen, Hasse Karlsson
Maternal prenatal psychological symptoms are associated with child health outcomes, e.g., atopic diseases. Altered prenatal functioning of the immune system is a potential mechanism linking maternal symptoms with child health. Research on prenatal distress and cytokines is warranted. The study population comprised consecutive N = 139 women from a general population-based FinnBrain Birth Cohort Study. Standardized questionnaires for depressive, overall anxiety, and pregnancy-related anxiety symptoms were used...
October 4, 2016: Archives of Women's Mental Health
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