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Prenatal anxiety

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https://www.readbyqxmd.com/read/29026448/newborn-genome-wide-dna-methylation-in-association-with-pregnancy-anxiety-reveals-a-potential-role-for-gabbr1
#1
Elise Beau Vangeel, Ehsan Pishva, Titia Hompes, Daniel van den Hove, Diether Lambrechts, Karel Allegaert, Kathleen Freson, Benedetta Izzi, Stephan Claes
BACKGROUND: There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregnancy anxiety using a genome-wide DNA methylation approach. METHODS: We selected 22 versus 23 newborns from our Prenatal Early Life Stress (PELS) cohort, exposed to the lowest or highest degree of maternal pregnancy anxiety, respectively. Cord blood genome-wide DNA methylation was assayed using the HumanMethylation450 BeadChip (HM450, n = 45) and candidate gene methylation using EpiTYPER (n = 80)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29024982/re-examining-the-link-between-prenatal-maternal-anxiety-and-child-emotional-difficulties-using-a-sibling-design
#2
Mona Bekkhus, Yunsung Lee, Rannveig Nordhagen, Per Magnus, Sven O Samuelsen, Anne I H Borge
Background: Prenatal exposure to maternal anxiety has been associated with child emotional difficulties in a number of epidemiological studies. One key concern, however, is that this link is vulnerable to confounding by pleiotropic genes or environmental family factors. Methods: Data on 82 383 mothers and children from the population-based Mother and Child Cohort Study and data on 21 980 siblings were used in this study. Mothers filled out questionnaires for each unique pregnancy, for infant difficulties at 6 months and for emotional difficulties at 36 months...
September 8, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28988636/-maternal-anxiety-related-to-how-the-pediatrician-provided-prenatal-information-about-preterm-birth
#3
C Dekens, C Fontaine, E Carpentier, L Barcat, J Gondry, P Tourneux
INTRODUCTION: Women hospitalized for preterm labor require clear information about prematurity. This study assessed whether or not specific written information about prematurity delivered at admission to the unit combined with an oral explanation from a pediatrician would decrease women's anxiety compared to an oral explanation alone. MATERIAL AND METHODS: This was a prospective, single-center observational study. Women were included in the high-risk pregnancies department and distributed into two groups: receiving "only oral" information for a prenatal clinical consultation with a senior pediatrician or receiving "combined" oral information+a booklet about prematurity given to the women at admission...
October 4, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28988271/bridging-the-gap-from-prenatal-karyotyping-to-whole-genome-array-comparative-genomic-hybridization-in-hong-kong-survey-on-knowledge-and-acceptance-of-health-care-providers-and-pregnant-women
#4
Hiu Yee Heidi Cheng, Anita Sik-Yau Kan, Pui Wah Hui, Chin Peng Lee, Mary Hoi Yin Tang
PURPOSE: The use of array comparative genomic hybridization (aCGH) has been increasingly widespread. The challenge of integration of this technology into prenatal diagnosis was the interpretation of results and communicating findings of unclear clinical significance. This study assesses the knowledge and acceptance of prenatal aCGH in Hong Kong obstetricians and pregnant women. The aim is to identify the needs and gaps before implementing the replacement of karyotyping with aCGH. Questionnaires with aCGH information in the form of pamphlets were sent by post to obstetrics and gynecology doctors...
October 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28972389/parental-expressions-of-anxiety-and-child-temperament-in-toddlerhood-jointly-predict-preschoolers-avoidance-of-novelty
#5
Evin Aktar, Mirjana Majdandžić, Wieke De Vente, Susan M Bögels
This study investigated the link between (a) parents' social trait and state anxiety and (b) children's fear and avoidance in social referencing situations in a longitudinal design and considered the modulating role of child temperament in these links. Children were confronted with a stranger and a robot, separately with their father and mother at 1 (N = 122), at 2.5 (N = 117), and at 4.5 (N = 111) years of age. Behavioral inhibition (BI) was separately observed at 1 and 2.5 years. Parents' social anxiety disorder (SAD) severity was assessed via interviews prenatally and at 4...
October 3, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28969480/maternal-stress-in-pregnancy-affects-myelination-and-neurosteroid-regulatory-pathways-in-the-guinea-pig-cerebellum
#6
Greer A Bennett, Hannah K Palliser, Julia C Shaw, Kerrin L Palazzi, David W Walker, Jonathan J Hirst
Prenatal stress predisposes offspring to behavioral pathologies. These may be attributed to effects on cerebellar neurosteroids and GABAergic inhibitory signaling, which can be linked to hyperactivity disorders. The aims were to determine the effect of prenatal stress on markers of cerebellar development, a key enzyme in neurosteroid synthesis and the expression of GABAA receptor (GABAAR) subunits involved in neurosteroid signaling. We used a model of prenatal stress (strobe light exposure, 2 h on gestational day 50, 55, 60 and 65) in guinea pigs, in which we have characterized anxiety and neophobic behavioral outcomes...
October 2, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28959195/prenatal-exposure-to-paint-thinner-alters-postnatal-development-and-behavior-in-mice
#7
Hanaa Malloul, Ferdaousse M Mahdani, Mohammed Bennis, Saadia Ba-M'hamed
Occupational exposure and sniffing of volatile organic solvents continue to be a worldwide health problem, raising the risk for teratogenic sequelae of maternal inhalant abuse. Real life exposures usually involve simultaneous exposures to multiple solvents, and almost all the abused solvents contain a mixture of two or more different volatile compounds. However, several studies examined the teratogenicity due to industrial exposure to a single volatile solvent but investigating the teratogenic potential of complex chemical mixture such as thinner remains unexplored...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28956168/continuity-of-midwifery-carer-moderates-the-effects-of-prenatal-maternal-stress-on-postnatal-maternal-wellbeing-the-queensland-flood-study
#8
Sue Kildea, Gabrielle Simcock, Aihua Liu, Guillaume Elgbeili, David P Laplante, Adele Kahler, Marie-Paule Austin, Sally Tracy, Sue Kruske, Mark Tracy, Michael W O'Hara, Suzanne King
Poor postnatal mental health is a major public health issue, and risk factors include experiencing adverse life events during pregnancy. We assessed whether midwifery group practice, compared to standard hospital care, would protect women from the negative impact of a sudden-onset flood on postnatal depression and anxiety. Women either received midwifery group practice care in pregnancy, in which they were allocated a primary midwife who provided continuity of care, or they received standard hospital care provided by various on-call and rostered medical staff...
September 27, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28947110/genetic-testing-for-huntington-disease
#9
Kimberly A Quaid
In 1983, Huntington disease (HD) became the first disease to be mapped to a previously unknown location on chromosome 4. This discovery meant that we could now identify whether some individuals at risk for HD would develop HD in the future using a method called linkage testing. Testing was first offered through research protocols designed to assess whether testing could be done safely in this population. Testing guidelines were soon developed by the Huntington's Disease Society of America and the International Huntington Association in collaboration with the World Federation of Neurology...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28929496/a-methylome-wide-association-study-of-trajectories-of-oppositional-defiant-behaviors-and-biological-overlap-with-attention-deficit-hyperactivity-disorder
#10
Edward D Barker, Esther Walton, Charlotte A M Cecil, Richard Rowe, Sara R Jaffee, Barbara Maughan, Thomas G O'Connor, Argyris Stringaris, Alan J Meehan, Wendy McArdle, Caroline L Relton, Tom R Gaunt
In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable...
September 20, 2017: Child Development
https://www.readbyqxmd.com/read/28927326/decision-outcomes-in-women-offered-noninvasive-prenatal-test-nipt-for-positive-down-screening-results
#11
Tsz-Kin Lo, Kelvin Yuen-Kwong Chan, Anita Sik-Yau Kan, Po-Lam So, Choi-Wah Kong, Shui-Lam Mak, Chung-Nin Lee
In this first Asian study, the decision outcomes (decision conflict, decision regret, and anxiety) of 262 pregnant women offered noninvasive prenatal test (NIPT) for high-risk Down screening results were assessed. Decision conflict was experienced by 3.5% and level of decisional regret low (mean score 15.7, 95%CI 13.2-18.3). All 13 cases of decisional regret were NIPT acceptors. Elevated anxiety was experienced by 55.9% at the time of decision making about NIPT and persistent in 30.3%. Insufficient knowledge about NIPT was associated with elevated anxiety at decision making (p = ...
September 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28921898/maternal-chronic-folate-supplementation-ameliorates-behavior-disorders-induced-by-prenatal-high-fat-diet-through-methylation-alteration-of-bdnf-and-grin2b-in-offspring-hippocampus
#12
Zhonghai Yan, Fei Jiao, Xiaoshuang Yan, Hailong Ou
SCOPE: Maternal consumption of a high-fat diet (HFD) during pregnancy increases the risk of behavioral problems. Folate plays an important role in neuroplasticity and the preservation of neuronal integrity. This study aimed at determining the influence of diets supplemented with folate on offspring behavior, and the mechanisms involved. METHODS AND RESULTS: Female mice were fed a control diet, a high-fat diet, control diet supplemented with folate, or a high-fat diet supplemented with folate for 5 wks before mating...
September 17, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28921607/in-labor-or-in-limbo-the-experiences-of-women-undergoing-induction-of-labor-in-hospital-findings-of-a-qualitative-study
#13
Annabel Jay, Hilary Thomas, Fiona Brooks
BACKGROUND: Induction of labor currently accounts for around 25% of all births in high-resource countries, yet despite much research into medical aspects, little is known about how women experience this process. This study aimed to explore in depth the induction experience of primiparous women. METHODS: A qualitative study was undertaken, using a sample of 21 first-time mothers from a maternity unit in the south of England. Semi-structured interviews were conducted in women's homes between 3 and 6 weeks postnatally...
September 17, 2017: Birth
https://www.readbyqxmd.com/read/28915376/psychometric-properties-of-the-postpartum-bonding-questionnaire-and-correlates-of-mother-infant-bonding-impairment-in-italian-new-mothers
#14
Alessandra Busonera, Stefania Cataudella, Jessica Lampis, Marco Tommasi, Giulio Cesare Zavattini
OBJECTIVE: impaired maternal bonding is a risk factor for problems with infant well-being and development. The investigation of perinatal variables related to disorders of the mother-infant relationship as well as the administration of reliable and valid screening tools to new mothers in the postpartum can help identify early signs of a disturbed mother-child relationship. The Postpartum Bonding Questionnaire (PBQ) has been shown to be a valid screening instrument, but its dimensional structure is still controversial...
September 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28910253/characterizing-non-monosexual-women-at-risk-for-poor-mental-health-outcomes-a-mixed-methods-study
#15
Lori E Ross, Melissa H Manley, Abbie E Goldberg, Alia Januwalla, Keisha Williams, Corey E Flanders
OBJECTIVES: Non-monosexual women - those who report attraction to or sexual relationships with individuals of more than one gender - have elevated risk for poor mental health outcomes. We aimed to examine which elements of non-monosexual experience are associated with this elevated risk. METHODS: We conducted a sequential exploratory mixed methods analysis of qualitative interview and survey data from 39 non-monosexual women recruited consecutively through prenatal care providers...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28905985/it-is-time-for-routine-screening-for-perinatal-mood-and-anxiety-disorders-in-obstetrics-and-gynecology-settings
#16
Eynav Elgavish Accortt, Melissa S Wong
Importance: Women are 2 to 3 times more likely than men to experience depression in their lifetime, and the greatest risk occurs during the reproductive years. As an obstetrics and gynecology physician or provider, you will likely encounter women who are at risk of development or relapse of a mental disorder during this vulnerable time. Objective: The aim of this review is to examine theory and research on mood and anxiety disorders during the perinatal period with an emphasis on screening recommendations...
September 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28902327/anxiety-in-pregnancy-prevalence-and-associated-factors
#17
Mônica Maria de Jesus Silva, Denismar Alves Nogueira, Maria José Clapis, Eliana Peres Rocha Carvalho Leite
OBJECTIVE: Evaluating the occurrence of anxiety in pregnant women and the factors associated with its occurrence; comparing the presence of anxiety in each gestational trimester. METHOD: A descriptive, correlational cross-sectional study. Data were collected from January to May 2013 using the Hospital Anxiety Subscale and a form composed of socioeconomic characterization; gestational anamnesis; life-changing habits and events; preexisting conditions and interpersonal relationships...
August 28, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28900372/psychological-stress-has-a-higher-rate-of-developing-addictive-behaviors-compared-to-physical-stress-in-rat-offspring
#18
Masoud Nazeri, Arezoo Ebrahimi, Iraj Aghaei, Samaneh Ghotbi Ravandi, Mohammad Shabani
Prenatal stress could have great influence on development of offspring and might alter cognitive function and other physiological processes of children. The current study was conducted to study the effect of physical or psychological prenatal stress on addictive and anxiety-like behavior of male and female offspring during their adolescence period (postnatal day (PND) 40). Adult female rats were exposed to physical (swimming) or psychological (observing another female rat swimming) stress from day six of gestation for 10 days...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28893219/a-case-of-a-four-year-old-child-adopted-at-eight-months-with-unusual-mood-patterns-and-significant-polypharmacy
#19
Magdalena Romanowicz, Alastair J McKean, Jennifer Vande Voort
BACKGROUND: Long-term effects of neglect in early life are still widely unknown. Diversity of outcomes can be explained by differences in genetic risk, epigenetics, prenatal factors, exposure to stress and/or substances, and parent-child interactions. Very common sub-threshold presentations of children with history of early trauma are challenging not only to diagnose but also in treatment. CASE PRESENTATION: A Caucasian 4-year-old, adopted at 8 months, male patient with early history of neglect presented to pediatrician with symptoms of behavioral dyscontrol, emotional dysregulation, anxiety, hyperactivity and inattention, obsessions with food, and attachment issues...
September 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28886563/prenatal-anxiety-effects-a-review
#20
Tiffany Field
This review is based on literature on prenatal anxiety effects that was found on Pubmed and PsycINFO for the years 2010-2016. Prenatal anxiety is thought to have distinct features, although it has been measured both by specific prenatal anxiety symptoms as well as by standardized anxiety scales. Its prevalence has ranged from 21 to 25% and it has been predicted by a number of pregnancy - related variables such as unintended pregnancy, demographic variables such as low acculturation and income and psychosocial factors including pessimism and partner tension...
September 5, 2017: Infant Behavior & Development
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