Read by QxMD icon Read

Prenatal anxiety

I P Butkevich, V A Mikhailenko
We studied the effect of chronic injections of serotonin reuptake inhibitor fluoxetine to rats during pregnancy on physiological and behavioral characteristics of female offspring during the prepubertal period. Fluoxetine reduced body weight in newborn females, but this parameter was restored to normal values by the age of 25 days. Fluoxetine also increased animal anxiety, but did not change the level of depressive behavior and cognitive capacities. It was shown that chronic injections of physiological solution to pregnant female enhanced nociceptive responses in the offspring during the prepubertal period, while fluoxetine neutralized the consequences of invasive intervention, which was expressed in a lower level of pain reaction in the offspring...
June 19, 2018: Bulletin of Experimental Biology and Medicine
Erin Hetherington, Sheila McDonald, Tyler Williamson, Scott B Patten, Suzanne C Tough
BACKGROUND: Low social support is consistently associated with postpartum depression. Previous studies do not always control for previous mental health and do not consider what type of support (tangible, emotional, informational or positive social interaction) is most important. The objectives are: to examine if low social support contributes to subsequent risk of depressive or anxiety symptoms and to determine which type of support is most important. METHODS: Data from the All Our Families longitudinal pregnancy cohort were used (n=3057)...
June 19, 2018: Journal of Epidemiology and Community Health
Aqeela Zahra, Jinxiang Jiang, Yunan Chen, Cheng Long, Li Yang
Prenatal exposure to citalopram (CTM), an antidepressant drug, has been associated with altered behavior, including autism-like symptoms in both human and rodent offspring. However, the neurological basis underlying these abnormal behaviors is not well understood. Here, we examined behavioral, morphological, and biochemical alterations in the male and female offspring of C57BL/6 mouse mothers that had been exposed to CTM during the last trimester of gestation. We observed abnormal behavior such as anxiety, altered locomotion and disordered social interactions in 2-5 month old offspring with prenatal CTM exposure...
June 15, 2018: Experimental Neurology
Kimberly C Lomonaco-Haycraft, Jennifer Hyer, Britney Tibbits, Jennifer Grote, Kelly Stainback-Tracy, Claire Ulrickson, Alison Lieberman, Lies van Bekkum, M Camille Hoffman
IntroductionPerinatal mood and anxiety disorders (PMADs) are the most common complication of pregnancy and have been found to have long-term implications for both mother and child. In vulnerable patient populations such as those served at Denver Health, a federally qualified health center the prevalence of PMADs is nearly double the nationally reported rate of 15-20%. Nearly 17% of women will be diagnosed with major depression at some point in their lives and those numbers are twice as high in women who live in poverty...
June 18, 2018: Primary Health Care Research & Development
Judith Osok, Pius Kigamwa, Keng-Yen Huang, Nancy Grote, Manasi Kumar
BACKGROUND: Adolescent pregnancies present a great public health burden in Kenya and Sub-Saharan Africa (UNFPA, Motherhood in Childhood: Facing the challenge of Adolescent Pregnancy, 2013). The disenfranchisement from public institutions and services is further compounded by cultural stigma and gender inequality creating emotional, psychosocial, health, and educational problems in the lives of vulnerable pregnant adolescents (Int J Adolesc Med Health 15(4):321-9, 2003; BMC Public Health 8:83, 2008)...
June 15, 2018: BMC Women's Health
Zeynep Ozturk Inal, Umit Gorkem, Hasan Ali Inal
OBJECTIVE: The aim of this study was to determine the effects of preoperative anxiety on the postoperative pain and analgesic consumption in patients undergoing cesarean deliveries (CDs). MATERIALS AND METHODS: This observational cohort study included 160 women, with ages ranging from 18-40 years old and a 37-week minimum gestation, received general (Group 1, n = 80) or spinal (Group 2, n = 80) anesthesia during an elective cesarean delivery. The State Anxiety Inventory (SAI), Trait Anxiety Inventory (TAI), and Somatosensory Amplification Scale (SSAS) were used to measure the prenatal anxiety...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Christine Laganière, Hélène Gaudreau, Irina Pokhvisneva, Leslie Atkinson, Michael Meaney, Marie-Hélène Pennestri
Sleep rhythmic movements have been speculated to be a form of self-soothing. While this sleep-related movement has been associated with lower socioeconomic status, psychopathologies and maternal characteristics, prospective studies with sizeable sample and objective measurements are lacking. The objectives were: (a) to identify maternal characteristics predicting sleep rhythmic movements in children; and (b) to document behavioural/emotional problems in preschoolers with sleep rhythmic movements. Participants were mother-child dyads (N = 529) from the Adversity: Maternal Adversity, Vulnerability and Neurodevelopment cohort...
June 5, 2018: Journal of Sleep Research
Jennifer E Khoury, Brittany Jamieson, Karen Milligan
Prenatal alcohol exposure (PAE) is associated with a constellation of physical, neurocognitive and behavioral abnormalities in offspring. The presence of internalizing (e.g., anxiety, mood disorders) and externalizing (e.g., oppositional defiant and conduct disorders) behavior problems have devastating and often long-lasting impacts on children, adolescents and their families. The present meta-analysis explored the strength of the association between PAE and behavior problems, as well as factors that increase or mitigate risk...
May 31, 2018: Alcoholism, Clinical and Experimental Research
Alejandra Hernández, Alonso Fernández-Guasti
Sex preference in male rats is partly determined by the organizational action of estradiol. Thus, several paradigms have used aromatase inhibitors to manipulate sex preference. We recently showed that a subpopulation of male rats prenatally treated with letrozole (0.56 μg/kg, G10-G22), a non-steroidal third generation aromatase inhibitor, had same sex preference, female sexual behavior (including lordosis and proceptivity) and penile erections when exposed to other males. These males, in addition, displayed high levels of experimental anxiety in the plus maze test and were insensitive to the anxiogenic-like acute effect of FLX (10 mg/kg)...
May 25, 2018: Pharmacology, Biochemistry, and Behavior
S Zullino, T Simoncini
SSRIs are the first choice for the treatment of mood disorders during pregnancy and lactation. Despite the known side effects, the benefits/risks balance suggests their use. Hypertensive disorders of pregnancy (HDP) and Intrauterine growth restriction (IUGR) are the main vascular effects of these drugs, with mechanisms that involves endothelial dysfunction in feto-placental system. These data are supported by animal models, even if preliminary findings are not yet adequately supported by molecular and clinical data...
May 24, 2018: Vascular Pharmacology
Ana García-Blanco, Vicente Diago, David Hervás, Farah Ghosn, Máximo Vento, Consuelo Cháfer-Pericás
STUDY QUESTION: Does in vitro fertilization (IVF) affect the course of anxiety and depressive symptoms as well as physiological stress from pregnancy to postpartum period? SUMMARY ANSWER: IVF mothers have more anxiety symptoms and higher stress biomarker levels but fewer depression symptoms than natural conception mothers at the third trimester of pregnancy, but these differences are negligible during postpartum period. WHAT IS KNOWN ALREADY: Cross-sectional studies have found an association between IVF and high stress levels during the prenatal period...
May 23, 2018: Human Reproduction
Valentina Brachetta, Cristian E Schleich, Ana P Cutrera, Julieta L Merlo, Marcelo J Kittlein, Roxana R Zenuto
In pregnant females, a failed predatory event not only induces individual responses but also represents a significant change in the developmental environment of the offspring, which may lead to modifications in their phenotype that may persist at different stages of life. We evaluate whether prenatal exposure to predatory cues affects anxiety behavior, behavioral response to predator cues, stress response to immobilization, and immune response to sheep red blood cells (SRBC) and phytohemagglutinin (PHA) in juveniles of the subterranean rodent Ctenomys talarum...
May 21, 2018: Developmental Psychobiology
Maria Gilles, Henrike Otto, Isabell A C Wolf, Barbara Scharnholz, Verena Peus, Michael Schredl, Marc W Sütterlin, Stephanie H Witt, Marcella Rietschel, Manfred Laucht, Michael Deuschle
BACKGROUND: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome. METHODS: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36...
April 22, 2018: Psychoneuroendocrinology
Ruthy Glass, Sara Norton, Nicholas Fox, Alexander W Kusnecov
Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like receptors. However, fewer studies have examined the role of direct activation of maternal T-cells during pregnancy using microbial agents...
May 14, 2018: Brain, Behavior, and Immunity
Ann Mary Iturra-Mena, Marcia Arriagada-Solimano, Ariane Luttecke-Anders, Alexies Dagnino-Subiabre
The fetal brain is highly susceptible to stress in late pregnancy, with lifelong effects of stress on physiology and behavior. The aim of this study was to determine the physiological and behavioral effects of prenatal stress during the prepubertal period of female and male rats. We subjected pregnant Sprague-Dawley rats to a restraint stress protocol from gestational day 14 until 21, a critical period for fetal brain susceptibility to stress effects. Male and female offspring were subsequently assessed at postnatal day 24 for anxiety- and depressive-like behaviors, and spontaneous social interaction...
May 17, 2018: Journal of Neuroendocrinology
Rebekah Kaplan, Sharon Adams
Ultrasonography is a common component of prenatal care worldwide and is often used in early pregnancy to determine gestational age, number of fetuses, fetal cardiac activity, and placental location. Patients and their families may also consider ultrasonography a social event, as it provides confirmation and reassurance of a normal pregnancy. Ultrasound screening is typically scheduled in the second trimester to visualize fetal anatomy and confirm gestational age. Most ultrasound examinations are reassuring, but some incidentally identify structural anomalies and soft markers for aneuploidy, making it necessary for health care providers to correctly interpret these findings...
May 15, 2018: Journal of Midwifery & Women's Health
Lydia E O Light, Thad Q Bartlett, Annica Poyas, Mark J Nijland, Hillary F Huber, Cun Li, Kate Keenan, Peter W Nathanielsz
BACKGROUND: We hypothesized that maternal nutrient restriction (NR) would increase activity and behavioral indicators of anxiety (self-directed behaviors, SDBs) in captive baboons (Papio sp.) and result in more protective maternal styles. METHODS: Our study included 19 adult female baboons. Seven females ate ad libitum (control group), and eight females ate 30% less (NR group) and were observed through pregnancy and lactation. RESULTS: Control females engage in higher rates of SDB than NR females overall (P ≤ ...
May 11, 2018: Journal of Medical Primatology
Robyn Brunton, Rachel Dryer, Anthony Saliba, Jane Kohlhoff
BACKGROUND: Recognition of pregnancy-related anxiety as a distinct anxiety is supported by evidence differentiating it from general anxiety and depression. Adverse associations with pregnancy-related anxiety further support this distinction. An influential study by Huizink et al. (2004), demonstrated that anxiety and depression contribute little to the variance of pregnancy-related anxiety, yet this study has not been replicated. Further, addressing limitations of the original study will provide further clarity to the findings...
May 7, 2018: Women and Birth: Journal of the Australian College of Midwives
Iveta Vojtechova, Tomas Petrasek, Kristyna Maleninska, Hana Brozka, Hana Tejkalova, Jiri Horacek, Ales Stuchlik, Karel Vales
Infection during the prenatal or neonatal stages of life is considered one of the major risk factors for the development of mental diseases such as schizophrenia or autism. However, the impacts of such an immune challenge on adult behavior are still not clear. In our study, we used a model of early postnatal immune activation by the application of bacterial endotoxin lipopolysaccharide (LPS) to rat pups at a dose of 2 mg/kg from postnatal day (PD) 5 to PD 9. In adulthood, the rats were tested in a battery of tasks probing various aspects of behavior: spontaneous activity (open field test), social behavior (social interactions and female bedding exploration), anxiety (elevated plus maze), cognition (active place avoidance in Carousel) and emotional response (ultrasonic vocalization recording)...
May 2, 2018: Behavioural Brain Research
Joyce Hopkins, Jennifer L Miller, Kristina Butler, Lynda Gibson, Laura Hedrick, Deborah Anne Boyle
OBJECTIVE: The aims of this study were to: (1) examine the relation between social support, trait anxiety, symptoms of maternal distress (including stress, depression and anxiety) and maternal-fetal attachment; and (2) to determine if social support buffers the relation between trait anxiety, symptoms of distress and maternal-fetal attachment. DESIGN: Ninety-four pregnant women completed five self-report questions. Two hierarchical regression analyses were conducted to examine the influence of trait anxiety, symptoms of distress, and social support on two factors of maternal-fetal attachment, quality and intensity/frequency...
May 4, 2018: Journal of Reproductive and Infant Psychology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"