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Prenatal anxiety

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https://www.readbyqxmd.com/read/28641949/reduced-protein-expressions-of-cytomembrane-gabaar%C3%AE-3-at-different-postnatal-developmental-stages-of-rats-exposed-prenatally-to-valproic-acid
#1
Yixin Li, Yang Zhou, Li Peng, Yong Zhao
Decreased inhibition plays an extremely important role in pathogenesis of autism spectrum disorder (ASD). Therefore, we aimed to determine whether expression levels of the γ-aminobutyric acid type A receptor β3 subunit (GABAARβ3), K(+)-Cl(-) cotransporter 2 (KCC2), and Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) related to inhibition transmission are changed in a sodium valproate-induced rat model of ASD. Decreased expression levels of membrane GABAARβ3 (m-GABAARβ3) and KCC2 as well as increased endocytosis of GABAARs were found in the model group...
June 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28641158/determinants-of-cortisol-during-pregnancy-the-abcd-cohort
#2
Laura S Bleker, Tessa J Roseboom, Tanja G Vrijkotte, Rebecca M Reynolds, Susanne R de Rooij
BACKGROUND: Psychosocial stress during pregnancy has been proposed as a major contributor of glucocorticoid-mediated programming of the fetal hypothalamic-pituitary adrenal (HPA) axis, with later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28634716/from-prenatal-anxiety-to-parenting-stress-a-longitudinal-study
#3
A C Huizink, B Menting, M H M De Moor, M L Verhage, F C Kunseler, C Schuengel, M Oosterman
The objective of this study was to explore how maternal mood during pregnancy, i.e., general anxiety, pregnancy-specific anxiety, and depression predicted parenting stress 3 months after giving birth, thereby shaping the child's early postnatal environmental circumstances. To this end, data were used from 1073 women participating in the Dutch longitudinal cohort Generations(2), which studies first-time pregnant mothers during pregnancy and across the transition to parenthood. Women filled out the State Trait Anxiety Inventory (STAI), Pregnancy-Related Anxiety Questionnaire-revised (PRAQ-R), and Beck Depression Index (BDI) three times during pregnancy: at 12, 22, and 32 weeks gestational age...
June 21, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28622973/maternal-programming-of-sex-specific-responses-to-predator-odor-stress-in-adult-rats
#4
Sophie St-Cyr, Sameera Abuaish, Shathveekan Sivanathan, Patrick O McGowan
Prenatal stress mediated through the mother can lead to long-term adaptations in stress-related phenotypes in offspring. This study tested the long-lasting effect of prenatal exposure to predator odor, an ethologically relevant and psychogenic stressor, in the second half of pregnancy. As adults, the offspring of predator odor-exposed mothers showed increased anxiety-like behaviors in commonly used laboratory tasks assessing novelty-induced anxiety, increased defensive behavior in males and increased ACTH stress reactivity in females in response to predator odor...
June 20, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28614354/maternal-prenatal-anxiety-and-child-comt-genotype-predict-working-memory-and-symptoms-of-adhd
#5
Kieran J O'Donnell, Vivette Glover, Jari Lahti, Marius Lahti, Rachel D Edgar, Katri Räikkönen, Thomas G O'Connor
Maternal prenatal anxiety is an important risk factor for altered child neurodevelopment but there is uncertainty concerning the biological mechanisms involved and sources of individual differences in children's responses. We sought to determine the role of functional genetic variation in COMT, which encodes catechol-O-methyltransferase, in the association between maternal prenatal anxiety and child symptoms of ADHD and working memory. We used the prospectively-designed ALSPAC cohort (n = 6,969) for our primary data analyses followed by replication analyses in the PREDO cohort (n = 425)...
2017: PloS One
https://www.readbyqxmd.com/read/28611606/long-term-sertraline-intake-reverses-the-behavioral-changes-induced-by-prenatal-stress-in-rats-in-a-sex-dependent-way
#6
Inês Pereira-Figueiredo, Orlando Castellano, Adelaida S Riolobos, Graça Ferreira-Dias, Dolores E López, Consuelo Sancho
Early life stress is a major factor underlying the vulnerability to respond to stressful events later in life. The present study attempted to evaluate the role of prenatal stress affecting the development of stress-related disorders and their reversion by postnatal exposure to Sertraline (SERT), a front-line medication for medication for posttraumatic stress disorder (PTSD) in humans. To achieve this, adult male and female prenatally stressed (PS) or unstressed (Controls) offspring rats, following oral chronic treatment with SERT (5 mg/kg/day; from 1 month to 4 months old), or not, were studied prior to and after a traumatic event...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28608856/antenatal-dexamethasone-exposure-differentially-affects-distinct-cortical-neural-progenitor-cells-and-triggers-long-term-changes-in-murine-cerebral-architecture-and-behavior
#7
M A Tsiarli, A Rudine, N Kendall, M O Pratt, R Krall, E Thiels, D B DeFranco, A P Monaghan
Antenatal administration of synthetic glucocorticoids (sGC) is the standard of care for women at risk for preterm labor before 34 gestational weeks. Despite their widespread use, the type of sGC used and their dose or the dosing regimens are not standardized in the United States of America or worldwide. Several studies have identified neural deficits and the increased risk for cognitive and psychiatric disease later in life for children administered sGC prenatally. However, the precise molecular and cellular targets of GC action in the developing brain remain largely undefined...
June 13, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28587054/later-life-changes-in-hippocampal-neurogenesis-and-behavioral-functions-after-low-dose-prenatal-irradiation-at-early-organogenesis-stage
#8
Ramya Ganapathi, Kailash Manda
PURPOSE: To investigate long-term changes in behavioral functions of mice after exposure to low-dose prenatal radiation at an early organogenesis stage. METHODS AND MATERIALS: Pregnant C57BL/6J mice were irradiated (20 cGy) at postcoitus day 5.5. The male and female offspring were subjected to different behavioral assays for affective, motor, and cognitive functions at 3, 6, and 12 months of age. Behavioral functions were further correlated with the population of CA1 and CA3 pyramidal neurons and immature neurons in hippocampal dentate gyrus...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28580568/causes-and-frequency-of-tocophobia-own-experiences
#9
Urszula Sioma-Markowska, Agnieszka Żur, Violetta Skrzypulec-Plinta, Mariola Machura, Mariola Czajkowska
OBJECTIVES: The phenomenon of tocophobia (pathological fear of labor) has not been fully explored. Currently, there are no diagnostic criteria that would enable its detection or make it recognizable as a disease entity. The aim of study was to determine the degree of anxiety/tocophobia as well as to learn about and analyze the causes of this phenomenon in Polish pregnant women. MATERIAL AND METHODS: The prospective study included 120 pregnant women in the third trimester of gestation from February to May 2016...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28571833/review-of-prenatal-maternal-mental-health-and-the-development-of-infant-temperament
#10
REVIEW
Nora L Erickson, Maria A Gartstein, Jo Ann Walsh Dotson
OBJECTIVE: To present a systematic review of literature and evaluate effects of prenatal maternal depression and anxiety on the development of infant temperament. DATA SOURCES: A literature search for studies published between January 1981 and January 2017 was undertaken using the electronic databases PsycINFO and PubMed, as well as reference lists from select resources. Search terms included variations on infant temperament, prenatal/pregnancy, depression, mood, and anxiety...
May 29, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28567007/involvement-of-the-cxcl12-system-in-the-stimulatory-effects-of-prenatal-exposure-to-high-fat-diet-on-hypothalamic-orexigenic-peptides-and-behavior-in-offspring
#11
Kinning Poon, Jessica R Barson, Huanzhi Shi, Guo Qing Chang, Sarah F Leibowitz
Exposure to a high fat diet (HFD) during gestation stimulates neurogenesis and expression of hypothalamic orexigenic neuropeptides that affect consummatory and emotional behaviors. With recent studies showing a HFD to increase inflammation, this report investigated the neuroinflammatory chemokine, CXCL12, and compared the effects of prenatal CXCL12 injection to those of prenatal HFD exposure, first, by testing whether the HFD affects circulating CXCL12 in the dam and the CXCL12 system in the offspring brain, and then by examining whether prenatal exposure to CXCL12 itself mimics the effects of a HFD on hypothalamic neuropeptides and emotional behaviors...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28565994/the-effects-of-silver-nanoparticles-on-behavior-apoptosis-and-nitro-oxidative-stress-in-offspring-wistar-rats
#12
Oana-Ofelia Dănilă, Alexandra Sevastre Berghian, Vlad Dionisie, Dan Gheban, Diana Olteanu, Flaviu Tabaran, Ioana Baldea, Gabriel Katona, Bianca Moldovan, Simona Clichici, Luminita David, Gabriela Adriana Filip
AIM: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. MATERIALS & METHODS: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis...
June 1, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28562247/neurodevelopment-the-impact-of-nutrition-and-inflammation-during-preconception-and-pregnancy-in-low-resource-settings
#13
Betty R Vohr, Elysia Poggi Davis, Christine A Wanke, Nancy F Krebs
The rapid pace of fetal development by far exceeds any other stage of the life span, and thus, environmental influences can profoundly alter the developmental course. Stress during the prenatal period, including malnutrition and inflammation, impact maternal and fetal neurodevelopment with long-term consequences for physical and mental health of both the mother and her child. One primary consequence of maternal malnutrition, inflammation, and other sources of prenatal stress is a poor birth outcome, such as prematurity or growth restriction...
April 2017: Pediatrics
https://www.readbyqxmd.com/read/28559916/maternal-sensitivity-and-social-support-protect-against-childhood-atopic-dermatitis
#14
Nicole L Letourneau, Anita L Kozyrskyj, Nela Cosic, Henry N Ntanda, Lubna Anis, Martha J Hart, Tavis S Campbell, Gerald F Giesbrecht
BACKGROUND: Many studies have identified associations between qualities of maternal-child relationships and childhood asthma, but few have examined associations with childhood atopic dermatitis (AD), a common precursor to asthma. Moreover, maternal psychological distress, including prenatal and postnatal depression, anxiety and stress, may increase risk, while social support from partners may reduce risk for childhood AD. We sought to uncover the association between maternal-infant relationship qualities (maternal sensitivity towards infant behavioral signals, controlling behavior, and unresponsiveness) and child AD after accounting for risk (i...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28556692/war-trauma-and-maternal-fetal-attachment-predicting-maternal-mental-health-infant-development-and-dyadic-interaction-in-palestinian-families
#15
Raija-Leena Punamäki, Sanna Isosävi, Samir R Qouta, Saija Kuittinen, Safwat Y Diab
Optimal maternal-fetal attachment (MFA) is believed to be beneficial for infant well-being and dyadic interaction, but research is scarce in general and among risk populations. Our study involved dyads living in war conditions and examined how traumatic war trauma associates with MFA and which factors mediate that association. It also modeled the role of MFA in predicting newborn health, infant development, mother-infant interaction, and maternal postpartum mental health. Palestinian women from the Gaza Strip (N = 511) participated during their second trimester (T1), and when their infants were 4 (T2) and 12 (T3) months...
May 30, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28556491/frequency-of-submicroscopic-chromosome-aberrations-in-pregnancies-without-increased-risk-for-structural-chromosome-aberrations-a-systematic-review-of-literature-and-meta-analysis
#16
REVIEW
Malgorzata I Srebniak, Marieke Joosten, Maarten F C M Knapen, Lidia R Arends, Marike Polak, Stefanie van Veen, Attie Go, Diane Van Opstal
OBJECTIVE: To establish the frequency of pathogenic submicroscopic chromosome aberrations in fetuses that are not at increased risk for unbalanced structural chromosome aberrations, a systematic literature search was performed. The aim was to determine whether high resolution testing for submicroscopic aberrations is beneficial in a general pregnant population. METHODS: On 3rd June 2016 Embase and PubMed databases were systematically searched for all relevant articles on prevalence of pathogenic submicroscopic CNVs in fetuses tested due to advanced maternal age or parental anxiety...
May 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28546819/the-effectiveness-of-counseling-in-reducing-anxiety-among-nulliparous-pregnant-women
#17
Parisa Parsa, Nafiseh Saeedzadeh, Seyedeh Zahra Masoumi, Ghodratallah Roshanaei
Objective: To determine the effectiveness of counseling in reducing anxiety of nulliparous pregnant women. Materials and methods: In this quasi-experimental study, 110 nulliparous pregnant women were selected out of all pregnant women referring to Fatemieh Hospital in Hamadan, Iran. Then, the subjects were divided into two groups in experimental and control (55 women in each). The data were collected through a questionnaire covering demographic and obstetric characteristics and Spielberger's State-Trait Anxiety Inventory...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28546058/the-role-of-il-6-in-neurodevelopment-after-prenatal-stress
#18
Serena B Gumusoglu, Rebecca S Fine, Samuel J Murray, Jada L Bittle, Hanna E Stevens
Prenatal stress exposure is associated with adverse psychiatric outcomes, including autism and ADHD, as well as locomotor and social inhibition and anxiety-like behaviors in animal offspring. Similarly, maternal immune activation also contributes to psychiatric risk and aberrant offspring behavior. The mechanisms underlying these outcomes are not clear. Offspring microglia and the pro-inflammatory cytokine interleukin-6 (IL-6), known to influence microglia, may serve as common mechanisms between prenatal stress and prenatal immune activation...
May 22, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28542256/maternal-depression-and-anxiety-disorders-mdad-and-child-development-a-manitoba-population-based-study
#19
Brenda Comaskey, Noralou P Roos, Marni Brownell, Murray W Enns, Dan Chateau, Chelsea A Ruth, Okechukwu Ekuma
OBJECTIVE: To examine the association between maternal depression and anxiety disorders (MDAD) and child development assessed during the kindergarten year. METHODS: Administrative data from several health and social databases in Manitoba, Canada, were used to study 18,331 mother-child pairs. MDAD over the period from one year prior to the child's birth to the kindergarten year was defined using physician diagnoses and filled prescriptions. Child development was assessed during the kindergarten year using the Early Development Instrument (EDI) which measures vulnerability across five domains of development...
2017: PloS One
https://www.readbyqxmd.com/read/28529444/childbirth-pain-attachment-orientations-and-romantic-partner-support-during-labor-and-delivery
#20
Carol L Wilson, Jeffry A Simpson
Attachment anxiety is associated with greater perceived physical pain, whereas social support is associated with lower pain perceptions. Few studies, however, have examined the joint effects of attachment and support on acute physical pain in a dyadic context. In this study, first-time expectant mothers (N=140) and their male partners completed romantic attachment measures (prenatally) and postnatal assessments of women's pain and men's emotional support during labor and delivery. More securely attached women benefited from emotional support in terms of reduced pain, more avoidantly attached women reported greater pain when given more support, and more anxiously attached women reported greater pain, regardless of their partner's support...
December 2016: Personal Relationships
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