Lucas C Pantaleão, Elena Loche, Denise S Fernandez-Twinn, Laura Dearden, Adriana Córdova-Casanova, Clive Osmond, Minna Salonen, Eero Kajantie, Youguo Niu, Juliana de Almeida-Faria, Benjamin D Thackray, Tuija Mikkola, Dino A Giussani, Andrew J Murray, Martin Bushell, Johan G Eriksson, Susan E Ozanne
OBJECTIVE: We investigated the potential involvement of miRNAs in the developmental programming of cardiovascular disease CVD by maternal obesity. METHODS: Serum miRNAs were measured in individuals from the Helsinki Birth Cohort (with known maternal body mass index), and a mouse model was used to determine causative effects of maternal obesity during pregnancy and ischemia-reperfusion on offspring cardiac miRNA expression and release. RESULTS: miR-15b-5p levels were increased in the sera of males born to mothers with higher BMI and in the hearts of adult mice born to obese dams...
January 11, 2024: Molecular Metabolism