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Obesogenic environment

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https://www.readbyqxmd.com/read/28090739/obesity-related-genetic-polymorphisms-and-adiposity-indices-in-a-young-italian-population
#1
Laura Bordoni, Francesca Marchegiani, Marco Piangerelli, Valerio Napolioni, Rosita Gabbianelli
Pediatric obesity develops when a complex biological predisposition collides with an obesogenic environment. To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR). We also tested the combinations of identified risk genotypes and epistatic interactions among them to determine the existence of cumulative effects in predicting the predisposition to gain weight...
January 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28088658/exposure-to-chronic-early-life-stress-lastingly-alters-the-adipose-tissue-the-leptin-system-and-changes-the-vulnerability-to-western-style-diet-later-in-life-in-mice
#2
K Y Yam, E F G Naninck, M R Abbink, S E la Fleur, L Schipper, J C van den Beukel, A Grefhorst, A Oosting, E M van der Beek, P J Lucassen, A Korosi
Early-life stress (ES) increases the vulnerability to develop psychopathologies and cognitive decline in adulthood. Interestingly, this is often comorbid with metabolic disorders, such as obesity. However, it is unclear whether ES leads to lasting metabolic changes and to what extent this is associated with the ES-induced cognitive impairments. Here, we used an established chronic ES mouse model (from postnatal day (P) 2 to P9) to investigate the short- and long-term effects of ES exposure on parameters of the adipose tissue and the leptin system (i...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28076762/a-leptin-analog-locally-produced-in-the-brain-acts-via-a-conserved-neural-circuit-to-modulate-obesity-linked-behaviors-in-drosophila
#3
Jennifer Beshel, Josh Dubnau, Yi Zhong
Leptin, a typically adipose-derived "satiety hormone," has a well-established role in weight regulation. Here we describe a functionally conserved model of genetically induced obesity in Drosophila by manipulating the fly leptin analog unpaired 1 (upd1). Unexpectedly, cell-type-specific knockdown reveals upd1 in the brain, not the adipose tissue, mediates obesity-related traits. Disrupting brain-derived upd1 in flies leads to all the hallmarks of mammalian obesity: increased attraction to food cues, increased food intake, and increased weight...
January 10, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28073954/gene-obesogenic-environment-interactions-in-the-uk-biobank-study
#4
Jessica Tyrrell, Andrew R Wood, Ryan M Ames, Hanieh Yaghootkar, Robin N Beaumont, Samuel E Jones, Marcus A Tuke, Katherine S Ruth, Rachel M Freathy, George Davey Smith, Stéphane Joost, Idris Guessous, Anna Murray, David P Strachan, Zoltán Kutalik, Michael N Weedon, Timothy M Frayling
BACKGROUND: Previous studies have suggested that modern obesogenic environments accentuate the genetic risk of obesity. However, these studies have proven controversial as to which, if any, measures of the environment accentuate genetic susceptibility to high body mass index (BMI). METHODS: We used up to 120 000 adults from the UK Biobank study to test the hypothesis that high-risk obesogenic environments and behaviours accentuate genetic susceptibility to obesity...
January 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27999679/early-rapid-weight-gain-and-subsequent-overweight-and-obesity-in-middle-childhood-in-peru
#5
Mary E Penny, M Michelle Jimenez, R Margot Marin
BACKGROUND: Rapid postnatal weight gain is associated with risk of overweight and obesity, but it's unclear whether this holds in populations exposed to concurrent obesogenic risk factors and for children who have been extensively breastfed. This study investigates whether an increase in weight for age from birth to 1 year (infancy) and from 1 to 5 years (early childhood) predicts overweight and obesity, and waist circumference at 8 years, using data from a longitudinal cohort study in Peru...
2016: BMC Obesity
https://www.readbyqxmd.com/read/27931993/age-period-cohort-analyses-of-obesity-prevalence-in-us-adults
#6
R An, X Xiang
OBJECTIVES: Age-period-cohort analysis is a stream of methodologies that decompose the temporal trends for disease risk into three time scales-age, calendar year (period) and year of birth (cohort). This study conducted age-period-cohort analyses of obesity prevalence in US adults. STUDY DESIGN: Retrospective data analysis. METHODS: We constructed regression models based on anthropometric data from the 1999-2012 National Health and Nutrition Examination Survey to correct for the self-reported height/weight in the 1984-2014 Behavioral Risk Factor Surveillance System (BRFSS)...
December 2016: Public Health
https://www.readbyqxmd.com/read/27927584/tribally-affiliated-child-care-center-environment-and-obesogenic-behaviors-in-young-children
#7
Susan B Sisson, Julie Stoner, Ji Li, Lancer Stephens, Janis E Campbell, Karina R Lora, Sandra H Arnold, Diane Horm, Beth DeGrace
BACKGROUND: Child-care centers are an integral part of life for many families with young children. American Indian children are at elevated health risk because of higher levels of obesity and associated health behaviors. OBJECTIVE: Our aim was to assess the child-care environment and children's physical activity (PA) and dietary intake in young children attending tribally affiliated child care. DESIGN: We conducted a cross-sectional study...
December 4, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27915080/a-nudge-in-a-healthier-direction-how-environmental-cues-help-restrained-eaters-pursue-their-weight-control-goal
#8
Aline E Stämpfli, Sabrina Stöckli, Thomas A Brunner
Losing weight is a goal for many people, but it is hard to pursue. However, dieting cues in the environment hold promise for improving individuals' eating behavior. For example, exposure to thin, human-like sculptures by the artist Alberto Giacometti has been found to promote healthy snack choices at a vending machine. Whether health- or weight-related processes drive such effects has not yet been determined. However, a detailed understanding of the content-related drivers of environmental cues' effects provides the first indications regarding a cue's possible use...
March 1, 2017: Appetite
https://www.readbyqxmd.com/read/27877118/contexts-paired-with-junk-food-impair-goal-directed-behavior-in-rats-implications-for-decision-making-in-obesogenic-environments
#9
Michael D Kendig, Ambrose M K Cheung, Joel S Raymond, Laura H Corbit
The high prevalence of obesity and related metabolic diseases calls for greater understanding of the factors that drive excess energy intake. Calorie-dense palatable foods are readily available and often are paired with highly salient environmental cues. These cues can trigger food-seeking and consumption in the absence of hunger. Here we examined the effects of palatable food-paired environmental cues on control of instrumental food-seeking behavior. In Experiment 1, adult male rats received exposures to one context containing three "junk" foods (JFs context) and another containing chow (Chow context)...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27848725/results-from-south-africa-s-2016-report-card-on-physical-activity-for-children-and-youth
#10
Monika Uys, Susan Bassett, Catherine E Draper, Lisa Micklesfield, Andries Monyeki, Anniza de Villiers, Estelle V Lambert
BACKGROUND: We present results of the 2016 Healthy Active Kids South Africa (HAKSA) Report Card on the current status of physical activity (PA) and nutrition in South African youth. The context in which we interpret the findings is that participation in PA is a fundamental human right, along with the right to "attainment of the highest standard of health." METHODS: The HAKSA 2016 Writing Group was comprised of 33 authorities in physical education, exercise science, nutrition, public health, and journalism...
November 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27845255/loss-of-lateral-prefrontal-cortex-control-in-food-directed-attention-and-goal-directed-food-choice-in-obesity
#11
Lieneke K Janssen, Iris Duif, Ilke van Loon, Joost Wegman, Jeanne H M de Vries, Roshan Cools, Esther Aarts
Loss of lateral prefrontal cortex (lPFC)-mediated attentional control may explain the automatic tendency to eat in the face of food. Here, we investigate the neurocognitive mechanism underlying attentional bias to food words and its association with obesity using a food Stroop task. We tested 76 healthy human subjects with a wide body mass index (BMI) range (19-35kg/m(2)) using fMRI. As a measure of obesity we calculated individual obesity scores based on BMI, waist circumference and waist-to-hip ratio using principal component analyses...
November 11, 2016: NeuroImage
https://www.readbyqxmd.com/read/27834179/-it-s-not-like-a-fat-camp-a-focus-group-study-of-adolescents-experiences-on-group-based-obesity-treatment
#12
Anna Engström, Eirik Abildsnes, Thomas Mildestvedt
BACKGROUND: The health burden related to obesity is rising among children and adolescents along with the general population worldwide. For the individual as well as the society this trend is alarming. Several factors are driving the trend, and the solution seems to be multifaceted because long-lasting treatment alternatives are lacking. This study aims to explore adolescents' and young adults' motivation for attending group-based obesity treatment and social and environmental factors that can facilitate or hinder lifestyle change...
2016: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/27827997/fto-deficiency-affects-the-gene-and-microrna-expression-involved-in-brown-adipogenesis-and-browning-of-white-adipose-tissue-in-mice
#13
Justiina Ronkainen, Eleonora Mondini, Francesca Cinti, Saverio Cinti, Sylvain Sebért, Markku J Savolainen, Tuire Salonurmi
Genetic variants in the fat mass- and obesity-associated gene Fto are linked to the onset of obesity in humans. The causal role of the FTO protein in obesity is supported by evidence obtained from transgenic mice; however, the underlying molecular pathways pertaining to the role of FTO in obesity have yet to be established. In this study, we investigate the Fto gene in mouse brown adipose tissue and in the browning process of white adipose tissue. We analyze distinct structural and molecular factors in brown and white fat depots of Fto-deficient mice under normal and obesogenic conditions...
November 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27818069/maternal-obesity-mediated-predisposition-to-respiratory-complications-at-birth-and-in-later-life-understanding-the-implications-of-the-obesogenic-intrauterine-environment
#14
REVIEW
Erin V McGillick, Mitchell C Lock, Sandra Orgeig, Janna L Morrison
More women than not are entering pregnancy either overweight or obese. This presents a significant health care burden with respect to maternal morbidities and offspring complications at birth and in later life. In recent years it has also become clear that maternal obesity is an even greater global health problem than anticipated, because the effects are not limited to the mother but are also programmed in the fetus, known as the 'intergenerational cycle of obestiy'. Despite a large body of epidemiological evidence reporting outcomes of obese pregnancies, including offspring respiratory complications, much less is known about the molecular effects of maternal obesity on fetal lung development...
October 11, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27796780/prevention-and-care-programs-addressing-the-growing-prevalence-of-diabetes-in-china
#15
REVIEW
Junmei Yin, Alice P S Kong, Juliana C N Chan
According to a 2010 national survey, 11 % of adults in China have diabetes, affecting 109.6 million individuals. The high prevalence of diabetes has been attributed to the aging of the population, the rapid adoption of energy-dense foods, and a reduction in physical activity. Collectively, these secular changes have created an obesogenic environment that can unmask diabetes in subjects with a genetic predisposition. The growing prevalence of maternal obesity, gestational diabetes, childhood obesity, and early-onset disease can lead to premature morbidity and mortality...
December 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27771443/the-interaction-between-physical-activity-and-obesity-gene-variants-in-association-with-bmi-does-the-obesogenic-environment-matter
#16
M Graff, A S Richardson, K L Young, A L Mazul, Heather Highland, K E North, K L Mohlke, L A Lange, E M Lange, K M Harris, P Gordon-Larsen
Little is known about how obesity susceptibility single nucleotide polymorphisms (SNPs) interact with moderate to vigorous physical activity (MVPA) in relation to BMI during adolescence, once obesogenic neighborhood factors are accounted for. In race stratified models, including European (EA; N=4977), African (AA; N=1726), and Hispanic Americans (HA; N=1270) from the National Longitudinal Study of Adolescent to Adult Health (1996; ages 12-21), we assessed the evidence for a SNPxMVPA interaction with BMI-for-age Z score, once accounting for obesogenic neighborhood factors including physical activity amenities, transportation and recreation infrastructure, poverty and crime...
November 2016: Health & Place
https://www.readbyqxmd.com/read/27759069/excessive-gain-in-body-mass-index-for-age-z-score-and-associated-factors-a-cohort-study-in-female-adolescents
#17
M L D Araújo, P C Cabral, I K G de Arruda, L de Souza Holanda, A S Diniz, R Maio, P B P Coelho
OBJECTIVE: To evaluate the occurrence of excessive gain in body mass index-for-age Z-score (BMI/AZ) and its associated factors in adolescent girls. METHODOLOGY: This is a cohort study conducted between 2007 and 2012 with 382 girls between 10 and 18 years of age attending public schools in Recife, Pernambuco, Brazil. Excessive gain in BMI/AZ (EGBMI/AZ) at follow-up was considered if the adolescent had a BMI/AZ >0.63 between follow-up and baseline. RESULTS: In 2007, 33...
October 19, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27730262/-the-idefics-primary-prevention-as-a-good-practice-example
#18
Iris Pigeot, Stefaan De Henauw, Wolfgang Ahrens
BACKGROUND: Worldwide the prevalence of childhood overweight and obesity is strikingly high. Prevention programs are therefore of high priority at a national and international level. In the framework of the IDEFICS study a primary prevention program was developed, implemented and evaluated. OBJECTIVE: This paper investigates to what degree the IDEFICS intervention may serve as good practice example. For this purpose, the single modules are described and the achieved effects are discussed...
November 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27702393/sex-comparative-analysis-of-the-mirnome-of-human-amniotic-mesenchymal-stem-cells-during-obesity
#19
Carmela Nardelli, Ilaria Granata, Laura Iaffaldano, Valeria D'Argenio, Valentina Del Monaco, Giuseppe Maria Maruotti, Luigi Del Vecchio, Pasquale Martinelli, Francesco Salvatore, Mario Rosario Guarracino, Lucia Sacchetti, Lucio Pastore
No abstract text is available yet for this article.
January 1, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/27698344/maternal-vitamin-d-beneficially-programs-metabolic-gut-and-bone-health-of-mouse-male-offspring-in-an-obesogenic-environment
#20
C R Villa, J Chen, B Wen, S M Sacco, A Taibi, W E Ward, E M Comelli
BACKGROUND/OBJECTIVES: Vitamin D is an anti-inflammatory nutrient and a determinant of bone health. Some prospective studies suggest that maternal vitamin D status is positively associated with offspring bone mass. We found that serum concentrations of lipopolysaccharide (LPS), an inflammatory molecule related to adiposity, insulin resistance and bone resorption, is lower in healthy mouse offspring exposed to high dietary vitamin D during pregnancy and lactation. LPS reaches the circulation via the gut...
December 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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