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hyperglycemia and mmse score in diabetic patients

Yi Dong Zhou, Huai Wu Yuan, Ren Jie Ji, Ben Yan Luo
Objective To investigate the influence and forecast value of stress hyperglycemia on the early vascular cognitive impairment (VCI) in stroke patients.Methods Totally 422 patients with acute non-diabetic stroke were divided into three groups according to the fasting plasma glucose level:the euglycemia group (<6.1 mmol/L),the mild stress hyperglycemia group (6.1-7.0 mmol/L),and the severe stress hyperglycemia group (≥7.0 mmol/L).Mini-mental state examination,Alzheimer's disease rating scale cognitive subscale,and clinical dementia rating scale were used to evaluate early cognition in post-stroke patients,and patients were divided into three groups accordingly:normal cognitive function group,mild VCI group,and vascular dementia group...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
J A Yoon, D Y Kim, M K Sohn, J Lee, S-G Lee, Y-S Lee, E Y Han, M C Joo, G-J Oh, J Han, S W Lee, M Park, W H Chang, Y-I Shin, Y-H Kim
BACKGROUND AND PURPOSE: We investigated the effect of stress hyperglycemia on the functional outcomes of non-diabetic hemorrhagic stroke. In addition, we investigated the usefulness of intensive rehabilitation for improving functional outcomes in patients with stress hyperglycemia. METHODS: Non-diabetic hemorrhagic stroke patients were recruited and divided into two groups: intracerebral hemorrhage (ICH) (n = 165) and subarachnoid hemorrhage (SAH) (n = 156). Each group was divided into non-diabetics with or without stress hyperglycemia...
November 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Lingning Huang, Liyong Yang, Ximei Shen, Sunjie Yan
Elderly patients with type 2 diabetes are at a greater risk for cognitive decline. The purpose of this study was to assess the relationship between the degree of hyperglycemia and cognitive status in nondemented, elderly diabetics. Between Jan 2013 and Dec 2014, 1174 geriatric patients with type 2 diabetes were enrolled in the study (579 males; age ≥ 60 years; from Fuzhou, Fujian, China). Cognitive function was measured with the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)...
April 2016: Metabolic Brain Disease
Maria Rosaria Rizzo, Michelangela Barbieri, Virginia Boccardi, Edith Angellotti, Raffaele Marfella, Giuseppe Paolisso
BACKGROUND: Older adults with type 2 diabetes have an increased risk for mild and severe cognitive impairment probably as consequence of chronic hyperglycemia or fasting plasma glucose levels. Variability in glucose level and recurrent hypoglycemic episodes are also associated with cognitive impairment. Dipeptidyl peptidase-4 inhibitor (DPP-4I) therapy affects glycemic variability. The purpose of this study was to evaluate the effect of DPP-4I therapy on changes in cognitive function in older patients with type 2 diabetes complicated by mild cognitive impairment...
September 2014: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Farah Madarshahian, Mohsen Hassanabadi, Mohsen Koshniat Nikoo
BACKGROUND: Type 2 diabetes along with chronic hyperglycemia may result in cognitive impairment. This can negatively affect the patient's adherence to diabetes treatment. The purpose of this study was to compare the cognitive status and foot self care practice in overweight type 2 diabetic patients who exercised regularly and those who did not. METHODS: The comparative study was conducted on 160 consecutive patients from an outpatient diabetes clinic. They were divided into two groups: The active group comprised of 80 patients engaged in regular exercise for at least 15-30 minutes, three times per week during the past 6 months...
2014: Journal of Diabetes and Metabolic Disorders
Maria Rosaria Rizzo, Raffaele Marfella, Michelangela Barbieri, Virginia Boccardi, Francesco Vestini, Biagio Lettieri, Silvestro Canonico, Giuseppe Paolisso
OBJECTIVE: The mean amplitude of glycemic excursions (MAGE) is a significant determinant of overall metabolic control as well as increased risk for diabetes complications. Older individuals with type 2 diabetes are more likely to have moderate cognitive deficits and structural changes in brain tissue. Considering that poor metabolic control is considered a deranging factor for cognitive performance in diabetic patients, we evaluated whether the contributions of MAGE to cognitive status in older patients with type 2 diabetes were independent from the main markers of glycemic control, such as sustained chronic hyperglycemia (A1C), postprandial glycemia (PPG), and fasting plasma glucose (FPG)...
October 2010: Diabetes Care
S A Ebady, M A Arami, M H Shafigh
OBJECTIVE: The incidence of cognitive impairment is increasing with age; however, little is known about the role of hyperglycemia in cognitive impairment. This study focuses on investigating the relationship between diabetes mellitus type 2 and cognitive impairment. METHODS: 60 diabetic patients, amongst whom, 30 had a well-controlled diabetes status and the other 30 had not. These patients were compared to 60 non-diabetic controls whose age, sex and educational class matched with the individuals of the first group...
December 2008: Diabetes Research and Clinical Practice
Cristina Geroldi, Giovanni B Frisoni, Giuseppe Paolisso, Stefania Bandinelli, Marco Lamponi, Angela Marie Abbatecola, Orazio Zanetti, Jack M Guralnik, Luigi Ferrucci
OBJECTIVE: To test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population. DESIGN: Cross-sectional wave of an epidemiologic longitudinal study (InCHIANTI). PARTICIPANTS: A total of 523 people, aged 70 to 90 years without diabetes mellitus or hyperglycemia, from the InCHIANTI cohort were included in the study. A total of 119 individuals had cognitive impairment (Mini-Mental State Examination [MMSE] score < 25), 21 of whom had both cognitive impairment and subcortical features (CI/SF+ group)...
July 2005: Archives of Neurology
Atsushi Araki
Insulin therapy is an effective measure of improving glucose control even in elderly patients with type 2 diabetes. However, it is controversial whether insulin therapy does disturb the quality of life (QOL) as well as cognitive function in the elderly. In our previous study of 455 diabetic patients, the well-being as assessed by the morale scale was similar in three treatment groups. In contrast, the symptom-burden, social burden, and worry about diabetes as assessed by the Elderly Diabetes Burden Scales was more increased in insulin-treated group as compared to the diet-treated group after adjustment for age, gender, HbAlc, frequency of hypoglycemia, microangiopathy, macroangiopathy, and social support...
March 2004: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Miguel N Hissa, José Artur C D'Almeida, Fernanda Cremasco, Veralice M S de Bruin
OBJECTIVES: The purpose of this study was to evaluate the ERP P300 in non insulin dependent diabetes mellitus (NIDDM) patients without cognitive impairment and the relationship with clinical variables, the presence of retinopathy and previous hypoglycemic episodes. METHODS: NIDDM patients (N=44) without evidence of cognitive impairment and controls (N=17) were studied clinically and with ancillary exams and the ERPs P300 were recorded. Patients were examined clinically and with the Folstein Mini-Mental Examination (MMSE) for cognitive function and all patients showed a score higher than 26 (maximal value=30)...
June 2002: Neuro Endocrinology Letters
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