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https://www.readbyqxmd.com/read/29343510/limited-radiographic-progression-and-sustained-reductions-in-mri-inflammation-in-patients-with-axial-spondyloarthritis-4-year-imaging-outcomes-from-the-rapid-axspa-phase-iii-randomised-trial
#1
Désirée van der Heijde, Xenofon Baraliakos, Kay-Geert A Hermann, Robert B M Landewé, Pedro M Machado, Walter P Maksymowych, Owen R Davies, Natasha de Peyrecave, Bengt Hoepken, Lars Bauer, Tommi Nurminen, Juergen Braun
OBJECTIVES: To report 4-year imaging outcomes in the RAPID-axSpA (NCT01087762) study of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), treated with certolizumab pegol (CZP). METHODS: This phase III, randomised trial was placebo-controlled and double-blind to week 24, dose-blind to week 48 and open-label to week 204. Patients fulfilling the Assessment of Spondyloarthritis International Society (ASAS) axSpA criteria with active disease were stratified (AS/nr-axSpA) according to the modified New York (mNY) criteria at randomisation...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29342471/extra-articular-manifestations-and-burden-of-disease-in-patients-with-radiographic-and-non-radiographic-axial-spondyloarthritis
#2
Kemal Erol, Kevser Gok, Gizem Cengiz, Gamze Kilic, Erkan Kilic, Salih Ozgocmen
OBJECTIVE: Although the prevalence of peripheral and extra-articular disease in ankylosing spondylitis (AS) has been assessed in many studies, data on non-radiographic axial spondyloarthritis (nr-axSpA) is scanty. The aim of this study was first, to compare radiographic-axSpA/AS (r-axSpA/AS) and nr-axSpA concerning peripheral arthritis and extra-articular manifestations (EAMs), and second, to assess potential differences between patient subgroups with or without EAMs regarding disease burden...
January 16, 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29333355/bilateral-peripheral-nerve-field-stimulation-for-intractable-coccygeal-pain-a-case-study-using-dual-lead-intercommunication
#3
Michelle Granville, Patrick T Brennan, Robert E Jacobson
Coccygeal pain is a difficult chronic pain problem with mixed response to various treatments. This is a report of a case of coccygeal pain that after failing various conservative and interventional procedures over five years was evaluated with a temporary peripheral sacral fascial lead followed by implantation of bilateral sacral paramedian leads for peripheral nerve field stimulation (PNFS). This resulted in marked pain control and resumption of full activity. The visual analog scale (VAS) pain score improved from eight pre-implant to one after implant and has remained at that level in follow-up...
November 9, 2017: Curēus
https://www.readbyqxmd.com/read/29333268/progress-of-genome-wide-association-studies-of-ankylosing-spondylitis
#4
REVIEW
Zhixiu Li, Matthew A Brown
Ankylosing spondylitis (AS) is an immune-mediated arthritis which primarily affects the spine and sacroiliac joints. Significant progress has been made in discovery of genetic associations with AS by genome-wide association studies (GWAS) over past decade. These findings have uncovered novel pathways involved pathogenesis of the disease and have led to introduction of novel therapeutic treatments for AS. In this Review, we discuss the genetic variations associated with AS identified by GWAS, the major pathways revealed by these AS-associated variations and critical cell types involved in AS development...
December 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29329434/effect-of-mechanical-stress-on-magnetic-resonance-imaging-of-the-sacroiliac-joints-assessment-of-military-recruits-by-magnetic-resonance-imaging-study
#5
Gaëlle Varkas, Manouk de Hooge, Thomas Renson, Sophie De Mits, Philippe Carron, Peggy Jacques, Muriel Moris, Geert Souverijns, Lennart Jans, Dirk Elewaut, Filip Van den Bosch
No abstract text is available yet for this article.
January 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29329380/circulating-micrornas-as-potential-biomarkers-of-disease-activity-and-structural-damage-in-ankylosing-spondylitis-patients
#6
Carlos Perez-Sanchez, Pilar Font-Ugalde, Patricia Ruiz-Limon, Chary Lopez-Pedrera, Maria C Castro-Villegas, Maria C Abalos-Aguilera, Nuria Barbarroja, Ivan Arias-de la Rosa, Maria D Lopez-Montilla, Alejandro Escudero-Contreras, Clementina Lopez-Medina, Eduardo Collantes-Estevez, Yolanda Jimenez-Gomez
Ankylosing spondylitis (AS) remains difficult to diagnose before irreversible damage to sacroiliac joint is noticeable. Circulating microRNAs have demonstrated to serve as diagnostic tools for several human diseases. Here, we analyzed plasma microRNAs to identify potential AS biomarkers. Higher expression levels of microRNA (miR)-146a-5p, miR-125a-5p, miR-151-3p, and miR-22-3p, and lower of miR-150-5p, and miR-451a were found in AS versus healthy donors. Interestingly, higher miR-146a-5p, miR-125a-5p, miR-151-3p, miR-22-3p, and miR-451a expression was also observed in AS than psoriatic arthritis patients...
January 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29313553/have-the-yearly-trends-of-total-hip-arthroplasty-in-ankylosing-spondylitis-patients-decreased
#7
Lee Bloom, John J Kelly, Jared M Newman, Nipun Sodhi, Robert Pivec, Assem A Sultan, Neil V Shah, Jaiben George, Anton Khlopas, Kim L Stearns, Carl B Paulino, Michael A Mont
INTRODUCTION: Ankylosing spondylitis (AS) is characterized by spinal inflammation and structural damage, primarily to the axial skeleton and sacroiliac joints. Between 25% and 70% of patients may experience progressive peripheral joint involvement, which, despite advancement in pharmacologic therapy, may necessitate surgical intervention. Total hip arthroplasty (THA) yields improved pain and functional outcomes for AS patients with hip involvement. It is unclear whether the annual rates of patients undergoing THA have changed due to newer pharmacologic management...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29306764/treatment-strategy-for-sacroiliac-joint-related-pain-at-or-around-the-posterior-superior-iliac-spine
#8
Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa
OBJECTIVE: Pain at or around the posterior superior iliac spine (PSIS) is characteristic of sacroiliac joint (SIJ) -related pain. This pain can be treated by either a peri- or intra-articular injection into the joint, with the former being much easier to perform. We investigated whether peri- or intra-articular injections were more frequently effective in patients with SIJ-related pain, and aimed to create an efficient treatment strategy for SIJ-related pain at or around the PSIS. DESIGN: Prospective case-control study...
December 21, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29303472/biomechanics-of-unilateral-and-bilateral-sacroiliac-joint-stabilization-laboratory-investigation
#9
Derek P Lindsey, Robin Parrish, Mukund Gundanna, Jeremi Leasure, Scott A Yerby, Dimitriy Kondrashov
OBJECTIVE Bilateral symptoms have been reported in 8%-35% of patients with sacroiliac (SI) joint dysfunction. Stabilization of a single SI joint may significantly alter the stresses on the contralateral SI joint. If the contralateral SI joint stresses are significantly increased, degeneration may occur; alternatively, if the stresses are significantly reduced, bilateral stabilization may be unnecessary for patients with bilateral symptoms. The biomechanical effects of 1) unilateral stabilization on the contralateral SI joint and 2) bilateral stabilization on both SI joints are currently unknown...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29299476/have-the-annual-trends-of-total-knee-arthroplasty-in-ankylosing-spondylitis-patients-decreased
#10
Roby Abraham, John J Kelly, Jared M Newman, Qais Naziri, Nipun Sodhi, Anton Khlopas, Jaiben George, Neil V Shah, Assem A Sultan, Morad Chughtai, John W Barrington, Carl B Paulino, Michael A Mont
Background: Ankylosing spondylitis (AS) is characterized by osteoproliferation-induced structural damage and spinal inflammation, which lead to spinal deformity and functional disability. Though AS commonly affects the axial skeleton and sacroiliac joints, up to 70% of patients have involvement of the knees and other joints. Despite pharmacological efforts, advancing joint involvement may ultimately require surgical intervention. Total knee arthroplasty (TKA) is effective in managing patients with AS, yet it remains unclear whether or not the annual rates of TKA have been affected...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29286972/delayed-bone-infarct-in-the-ilium-following-a-pelvic-crush-injury-and-embolization-a-case-report
#11
Paul W Millhouse, Andrew J Miller, Jonathan Paul, Theodore D Conliffe, Alexander R Vaccaro, Zach Broyer
CASE: We present a case of delayed osteonecrosis of the ilium. After receiving embolization and multiple orthopaedic procedures following a complex pelvic crush injury, the patient subsequently developed posterior pelvic pain and tenderness over the posterior superior iliac spine, along with pain on sacroiliac joint compression. Magnetic resonance imaging of the pelvis demonstrated a bone infarction in the left ilium adjacent to the sacroiliac joint. CONCLUSION: The symptoms from osteonecrosis of the ilium may simulate sacroiliitis or other conditions...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29285943/-assessment-of-sacroiliacal-joint-mobility-in-patients-with-low-back-pain
#12
Máté Burkus, István Márkus, Bálint Niklai, Miklós Tunyogi-Csapó
INTRODUCTION: Sagittal alignment of the pelvis is typically characterized using three fundamental parameters. Among these, pelvic incidence is traditionally considered to be anatomically 'constant'. AIM: We aimed to analyze the pelvic parameters of low back pain patients with suspected sacroiliac joint laxity. METHOD: Pelvic parameters were assessed in standing and seated EOS 2D/3D radiographs of 48 cases of persistent low back pain, and compared to upper body position using cluster analysis and t-test...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29284149/percutaneous-sacroiliac-screw-versus-anterior-plating-for-sacroiliac-joint-disruption-a-retrospective-cohort-study
#13
Ruipeng Zhang, Yingchao Yin, Shilun Li, Zhiyong Hou, Lin Jin, Yingze Zhang
BACKGROUND: Sacroiliac joint disruption (SJD) is a common cause of pelvic ring instability. Clinically, percutaneous unilateral S1 sacroiliac screw and anterior plating are always applied to manage SJD. The objective of this study is to elaborate their respective therapeutic traits. MATERIALS AND METHODS: Patients with SJD fixed with unilateral S1 sacroiliac screw or anterior plating from June 2011 to June 2015 were recruited into this study and were divided into two groups: group A (unilateral sacroiliac screw) and group B (anterior plating)...
December 25, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29279873/wandering-double-j-stent-in-the-retroperitoneum-a-case-report
#14
Sridhar Panaiyadiyan, Abhishek Shukla, Brusabhanu Nayak, Prabhjot Singh, Ashish Kumar Saini
Background: Double-J (DJ) stent is an integral part of urologic practice. DJ stents can have numerous complications such as persistent irritative symptoms, encrustations, and up and down migrations within the pelvicaliceal system (PCS), but displacement outside the urinary tract is rare. We are presenting a unique case of DJ stent lying outside the PCS for more than a decade. Case Presentation: A 46-year-old female presented with left flank pain and dysuria. She had undergone percutaneous nephrolithotomy in the left side 11 years ago...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29279813/the-assessment-of-fusion-following-sacroiliac-joint-fusion-surgery
#15
Hamid Abbasi, John A Hipp
Sacroiliac joint fusions (SIJF) have been the subject of many research studies. The technical success of an SIJF is in part determined by whether osseous bridging occurs across the sacroiliac joint (SIJ). However, no validated SIJF assessment method has been described. Our objective was to document previously described SIJF assessment methods and define and validate a detailed assessment system for SIJF. Our results are only intended to establish computed tomography (CT)-based guidelines for SIJF to be used in a subsequent large clinical study to correlate them with clinical outcomes...
October 20, 2017: Curēus
https://www.readbyqxmd.com/read/29277920/three-dimensional-morphological-analysis-of-the-human-sacroiliac-joint-influences-on-the-degenerative-changes-of-the-auricular-surfaces
#16
Keita Nishi, Toshiyuki Tsurumoto, Keishi Okamoto, Keiko Ogami-Takamura, Takashi Hasegawa, Takefumi Moriuchi, Junya Sakamoto, Joichi Oyamada, Toshio Higashi, Yoshitaka Manabe, Kazunobu Saiki
The sacroiliac joint (SIJ) is responsible for weight transmission between the spine and lower extremity. However, details of the structure and function of the SIJ remain unclear. In a previous study, we devised a method of quantitatively evaluating the level of degeneration of the SIJ using an age estimation procedure for the auricular surface of the ilium. Our results in that study suggested that the degree of degeneration of the joint surface may be associated with the morphology of the auricular surface of the ilium...
December 25, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29276467/chiropractic-management-using-multimodal-therapies-on-2-pediatric-patients-with-constipation
#17
Madhu Mia Iyer, Evangelia Skokos, Denise Piombo
Objective: The purpose of this case report is to describe chiropractic management of 7-month-old male twins who had had constipation since birth. Clinical Features: Identical male twins presented with the chief complaint of constipation and bloating. Both patients were born premature after 29 weeks of gestation and had invasive abdominal surgeries in the right lower quadrant resulting in healed postsurgical scars. Patient A underwent ileostomy for a perforation in his ileum...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29276462/chiropractic-care-in-the-management-of-inactive-ankylosing-spondylitis-a-case-series
#18
Stacey M Cornelson, David Beavers, Allison Harvey, William Hogarth, Norman W Kettner
Objective: This report describes chiropractic management for 3 cases of inactive ankylosing spondylitis (AS). Clinical Features: A 25-year-old woman presented with chronic, mechanical neck pain and stiffness that was ultimately diagnosed as AS. A 23-year-old man presented with chronic low back and left hip pain that was diagnosed as AS. A 31-year-old man with low back pain presented with a known diagnosis of AS. Physical examination in 2 cases failed to identify systemic findings associated with AS...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29250494/diagnosis-and-treatment-of-inflammatory-joint-disease
#19
REVIEW
Yeesuk Kim, Hyun-Cheol Oh, Jang Won Park, In-Sung Kim, Jun-Young Kim, Ki-Choul Kim, Dong-Sik Chae, Woo-Lam Jo, Joo-Hyoun Song
Arthritis damages the cartilage within joints, resulting in degenerative changes, including loss of function and joint instability. Ankylosing spondylitis (AS) is a chronic inflammatory condition affecting the spine and bone-to-tendon attachment area within the sacroiliac joint leading to back pain and progressive spinal stiffness. In the final stages, AS causes hyperkyphosis-a condition closely tied to the human leukocyte antigen-B27 gene. Rheumatoid arthritis is a chronic, systemic autoimmune disease characterized by the simultaneous inflammation of the synovium of multiple joints, leading to joint damage (e...
December 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#20
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
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