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Saturation monitoring

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https://www.readbyqxmd.com/read/28227822/a-wrist-worn-spo2-monitor-with-custom-finger-probe-for-motion-artifact-removal
#1
S P Preejith, Akshay S Ravindran, Rohan Hajare, Jayaraj Joseph, Mohanasankar Sivaprakasam, S P Preejith, Akshay S Ravindran, Rohan Hajare, Jayaraj Joseph, Mohanasankar Sivaprakasam, Akshay S Ravindran, Rohan Hajare, Sp Preejith, Jayaraj Joseph, Mohanasankar Sivaprakasam
Continuous monitoring of blood oxygen saturation (SpO2) level and heart rate is critical in surgery, ICUs and patients suffering from Chronic Obstructive Pulmonary Diseases. Pulse oximeters which compute SpO2 using transmittance photoplethysmography (PPG), is widely accepted for continuous monitoring. Presence of motion artifacts in PPG signals is a major obstacle in the extraction of reliable cardiovascular parameters, in real time and continuous monitoring applications. In this paper, a wrist worn device with a custom finger probe with an integrated accelerometer to remove motion artifacts is presented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227628/a-wearable-bluetooth-le-sensor-for-patient-monitoring-during-mri-scans
#2
Christian Vogt, Jonas Reber, Daniel Waltisberg, Lars Buthe, Josip Marjanovic, Niko Munzenrieder, Klaas P Pruessmann, Gerhard Troster, Christian Vogt, Jonas Reber, Daniel Waltisberg, Lars Buthe, Josip Marjanovic, Niko Munzenrieder, Klaas P Pruessmann, Gerhard Troster, Josip Marjanovic, Klaas P Pruessmann, Niko Munzenrieder, Christian Vogt, Lars Buthe, Gerhard Troster, Jonas Reber, Daniel Waltisberg
This paper presents a working prototype of a wearable patient monitoring device capable of recording the heart rate, blood oxygen saturation, surface temperature and humidity during an magnetic resonance imaging (MRI) experiment. The measured values are transmitted via Bluetooth low energy (LE) and displayed in real time on a smartphone on the outside of the MRI room. During 7 MRI image acquisitions of at least 1 min and a total duration of 25 min no Bluetooth data packets were lost. The raw measurements of the light intensity for the photoplethysmogram based heart rate measurement shows an increased noise floor by 50LSB (least significant bit) during the MRI operation, whereas the temperature and humidity readings are unaffected...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227573/video-monitoring-of-oxygen-saturation-during-controlled-episodes-of-acute-hypoxia
#3
Paul S Addison, David M H Foo, Dominique Jacquel, Ulf Borg, Paul S Addison, David M H Foo, Dominique Jacquel, Ulf Borg, Ulf Borg, Dominique Jacquel, Paul S Addison, David M H Foo
A method for extracting video photoplethysmographic information from an RGB video stream is tested on data acquired during a porcine model of acute hypoxia. Cardiac pulsatile information was extracted from the acquired signals and processed to determine a continuously reported oxygen saturation (SvidO2). A high degree of correlation was found to exist between the video and a reference from a pulse oximeter. The calculated mean bias and accuracy across all eight desaturation episodes were -0.03% (range: -0.21% to 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227082/long-term-quasi-continuous-oxygen-saturation-levels-obtained-from-sternal-photoplethysmography-on-patients-with-obstructive-lung-diseases
#4
Shadi S Chreiteh, Dorthe B Saadi, Bo Belhage, Nassim Nabipour, Karsten Hoppe, Erik V Thomsen, Shadi S Chreiteh, Dorthe B Saadi, Bo Belhage, Nassim Nabipour, Karsten Hoppe, Erik V Thomsen, Bo Belhage, Karsten Hoppe, Shadi S Chreiteh, Nassim Nabipour, Erik V Thomsen, Dorthe B Saadi
Calculation of long-term quasi-continuous oxygen saturation (SpO2) levels is highly relevant for critically ill patients. The purpose of this study is therefore to conduct a preliminary investigation of the clinical reliability of long-term photoplethysmography (PPG) recordings obtained from the sternum of patients admitted to the hospital with obstructive lung diseases. Due to the lack of a gold standard reference that is suitable for long-term monitoring without interfering with the patient's activity level, we extracted reliable segments based on knowledge from the basic pulse oximeter theory as well as knowledge about the inherent physiological regulation of the SpO2 levels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226208/tailoring-escherichia-coli-for-the-l-rhamnose-pbad-promoter-based-production-of-membrane-and-secretory-proteins
#5
Anna Hjelm, Alexandros Karyolaimos, Zhe Zhang, Edurne Rujas, David Vikström, Dirk Jan Slotboom, Jan-Willem de Gier
Membrane and secretory protein production in Escherichia coli requires precisely controlled production rates to avoid the deleterious saturation of their biogenesis pathways. Based on this requirement, the E. coli L-rhamnose PBAD promoter (PrhaBAD) is often used for membrane and secretory protein production since PrhaBAD is thought to regulate protein production rates in an L-rhamnose concentration dependent manner. By monitoring protein production in real-time in E. coli wild-type and an L-rhamnose catabolism deficient mutant, we demonstrate that the L-rhamnose concentration-dependent tunability of PrhaBAD-mediated protein production is actually due to L-rhamnose consumption rather than regulating production rates...
February 22, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28223372/perspectives-of-low-socioeconomic-status-mothers-of-premature-infants
#6
Elizabeth Enlow, Laura J Faherty, Sara Wallace-Keeshen, Ashley E Martin, Judy A Shea, Scott A Lorch
BACKGROUND AND OBJECTIVES: Transitioning premature infants from the NICU to home is a high-risk period with potential for compromised care. Parental stress is high, and families of low socioeconomic status may face additional challenges. Home visiting programs have been used to help this transition, with mixed success. We sought to understand the experiences of at-risk families during this transition to inform interventions. METHODS: Mothers of infants born at <35 weeks' gestation, meeting low socioeconomic status criteria, were interviewed by telephone 30 days after discharge to assess caregiver experiences of discharge and perceptions of home visitors (HVs)...
February 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/28220508/quantitative-long-term-measurements-of-burns-in-a-rat-model-using-spatial-frequency-domain-imaging-sfdi-and-laser-speckle-imaging-lsi
#7
Adrien Ponticorvo, David M Burmeister, Rebecca Rowland, Melissa Baldado, Gordon T Kennedy, Rolf Saager, Nicole Bernal, Bernard Choi, Anthony J Durkin
BACKGROUND AND OJECTIVES: The current standard for diagnosis of burn severity and subsequent wound healing is through clinical examination, which is highly subjective. Several new technologies are shifting focus to burn care in an attempt to help quantify not only burn depth but also the progress of healing. While accurate early assessment of partial thickness burns is critical for dictating the course of treatment, the ability to quantitatively monitor wound status over time is critical for understanding treatment efficacy...
February 21, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28219430/digital-health-system-for-personalised-copd-long-term-management
#8
Carmelo Velardo, Syed Ahmar Shah, Oliver Gibson, Gari Clifford, Carl Heneghan, Heather Rutter, Andrew Farmer, Lionel Tarassenko
BACKGROUND: Recent telehealth studies have demonstrated minor impact on patients affected by long-term conditions. The use of technology does not guarantee the compliance required for sustained collection of high-quality symptom and physiological data. Remote monitoring alone is not sufficient for successful disease management. A patient-centred design approach is needed in order to allow the personalisation of interventions and encourage the completion of daily self-management tasks...
February 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28218220/establishment-of-a-rabbit-model-of-chronic-obstructive-sleep-apnea-and-application-in-cardiovascular-consequences
#9
Li-Fang Xu, Xiu-Fang Zhou, Ke Hu, Si Tang, Yu-Chuan Luo, Wen Lu
BACKGROUND: Although obstructive sleep apnea (OSA) has been recognized as a major risk factor for cardiovascular complications and its clinical features are well characterized, it is difficult to replicate the OSA hypoxic model in humans. We aimed to establish an experimental rabbit model for chronic OSA and to explore its application to measure blood pressure (BP), myocardial systolic function, and oxidative stress. METHODS: The rabbit model for OSA was established by repeatedly closing the airway and then reopening it...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28217049/effectiveness-of-sodium-thiopentone-propofol-and-etomidate-as-an-ideal-intravenous-anesthetic-agent-for-modified-electroconvulsive-therapy
#10
Altaf Hussain Mir, Nida Farooq Shah, Mehraj Ud Din, Shabir Ahmad Langoo, Fayaz Ahmad Reshi
INTRODUCTION: Electroconvulsive therapy (ECT) is a well-established psychiatric treatment in which seizures are electrically induced in patients for therapeutic effects. ECT can produce severe disturbances in the cardiovascular system and a marked increase in cerebral blood flow and intracranial pressure. These cardiovascular changes may be altered using various anesthetic drugs. AIM AND OBJECTIVES: This study was undertaken to compare the effects of intravenous (IV) sodium thiopentone, propofol, and etomidate, used as IV anesthetic agents in modified ECT as regards, induction time and quality of anesthesia, alteration of hemodynamics, seizure duration, and recovery time...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28216706/monitored-anaesthesia-care-comparison-of-nalbuphine-dexmedetomidine-versus-nalbuphine-propofol-for-middle-ear-surgeries-a-double-blind-randomised-trial
#11
Srinivasa Rao Nallam, Sunil Chiruvella, Anjineswar Reddy
BACKGROUND AND AIMS: Middle ear surgeries (MESs) are usually performed under sedation with local anaesthesia and can be well tolerated by the patient with minimal discomfort. In the present study, we compare the effect of nalbuphine/dexmedetomidine combination with nalbuphine/propofol on sedation and analgesia in monitored anaesthesia care. METHODS: One hundred adult patients undergoing MESs under monitored anaesthesia care (MAC) were randomly allocated into two groups...
January 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28210440/analytical-parameters-and-vital-signs-in-patients-subjected-to-dental-extraction
#12
Enric Jané-Pallí, Carlos Arranz-Obispo, Beatriz González-Navarro, Jesús Murat, Raúl Ayuso-Montero, Santiago Rojas, Amparo Santamaría, Enric Jané-Salas, José López-López
BACKGROUND: Dental consultation may provoke stress to the patient, especially when a dental surgery is going to be performed, stressful situations can cause a reaction in the sympathetic nervous system that could lead to cardiovascular alterations. Blood pressure and cardiac frequency are used often as an indirect measurement and this parameters combined can serve as good indicators of stress. Objective: Analyze the changes in vital signs and analytical parameters induced by a dental extraction...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28208978/a-randomized-controlled-study-of-0-5-bupivacaine-0-5-ropivacaine-and-0-75-ropivacaine-for-supraclavicular-brachial-plexus-block
#13
Ranjan R Venkatesh, Prabhat Kumar, Ramachandran R Trissur, Sagiev Koshy George
INTRODUCTION: For any surgery in the upper extremity that does not involve the shoulder, a supraclavicular block is preferred, as it is a safe procedure associated with rapid onset and reliable anaesthesia. Although ropivacaine has been extensively studied for epidural anaesthesia, very few reports exist on its use in supraclavicular brachial plexus block. AIM: This study was conducted to investigate and compare the effectiveness of supraclavicular brachial plexus anaesthesia with two different concentrations of ropivacaine (0...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207743/lipidomic-approach-for-stratification-of-acute-myeloid-leukemia-patients
#14
Adam Stefanko, Christian Thiede, Gerhard Ehninger, Kai Simons, Michal Grzybek
The pathogenesis and progression of many tumors, including hematologic malignancies is highly dependent on enhanced lipogenesis. De novo fatty-acid synthesis permits accelerated proliferation of tumor cells by providing membrane components but these may also alter physicochemical properties of lipid bilayers, which can impact signaling or even increase drug resistance in cancer cells. Cancer type-specific lipid profiles would permit us to monitor and interpret actual effects of lipid changes, potential fingerprints of individual tumors to be explored as diagnostic markers...
2017: PloS One
https://www.readbyqxmd.com/read/28192441/cyclic-amp-regulates-postnatal-development-of-neural-and-behavioral-responses-to-nacl-in-rats
#15
Jie Qian, Shobha Mummalaneni, Tam-Hao T Phan, Gerard L Heck, John A DeSimone, David West, Sunila Mahavadi, Deanna Hojati, Karnam S Murthy, Mee-Ra Rhyu, Andrew I Spielman, Mehmet Hakan Özdener, Vijay Lyall
During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+ channels (ENaCs) in salt sensing fungiform (FF) taste receptor cells (TRCs). Currently, the intracellular signals that regulate the postnatal development of salt taste have not been identified. We investigated the effect of cAMP, a downstream signal for arginine vasopressin (AVP) action, on the postnatal development of NaCl responses in 19-23 day old rats...
2017: PloS One
https://www.readbyqxmd.com/read/28190559/use-of-renal-near-infrared-spectroscopy-measurements-in-congenital-diaphragmatic-hernia-patients-on-ecmo
#16
Patricio E Lau, Stephanie Cruz, Joseph Garcia-Prats, Milenka Cuevas, Christopher Rhee, Darrell L Cass, Sarah E Horne, Timothy C Lee, Stephen E Welty, Oluyinka O Olutoye
INTRODUCTION: This study tests the hypothesis that renal tissue oxygen saturation as measured by Near Infrared Spectroscopy (NIRS) would correlate with urine output in neonates with congenital diaphragmatic hernia (CDH) on extracorporeal membrane oxygenation (ECMO). METHODS: Between 2012 and 2015, neonates with CDH were enrolled as part of a comprehensive study that provided renal/cerebral/abdominal NIRS monitoring for the duration of ECMO support. Continuous NIRS measurements, mean arterial pressure, and urine output were recorded...
January 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28179366/genome-wide-chemical-mutagenesis-screens-allow-unbiased-saturation-of-the-cancer-genome-and-identification-of-drug-resistance-mutations
#17
Jonathan Brammeld, Mia Petljak, Inigo Martincorena, Steven P Williams, Luz Garcia Alonso, Alba Dalmases, Beatriz Bellosillo, Carla Daniela Robles-Espinoza, Stacey Price, Syd Barthorpe, Patrick Tarpey, Constantine Alifrangis, Graham Bignell, Joana Vidal, Jamie Young, Lucy Stebbings, Kathryn Beal, Michael R Stratton, Julio Saez-Rodriguez, Mathew Garnett, Clara Montagut, Francesco Iorio, Ultan McDermott
Drug resistance is an almost inevitable consequence of cancer therapy and ultimately proves fatal for the majority of patients. In many cases this is the consequence of specific gene mutations that have the potential to be targeted to re-sensitize the tumor. The ability to uniformly saturate the genome with point mutations without chromosome or nucleotide sequence context bias would open the door to identify all putative drug resistance mutations in cancer models. Here we describe such a method for elucidating drug resistance mechanisms using genome-wide chemical mutagenesis allied to next-generation sequencing...
February 8, 2017: Genome Research
https://www.readbyqxmd.com/read/28179102/impact-of-surface-grafting-density-of-peg-macromolecules-on-dually-fluorescent-silica-nanoparticles-used-for-the-in-vivo-imaging-of-subcutaneous-tumors
#18
Laurent Adumeau, Coralie Genevois, Lydia Roudier, Christophe Schatz, Franck Couillaud, Stéphane Mornet
BACKGROUND: In the context of systematically administered nanomedicines, the physicochemistry of NP surfaces must be controlled as a prerequisite to improve blood circulation time, and passive and active targeting. In particular, there is a real need to develop NP stealth and labelling for both in vivo and microscopic fluorescence imaging in a mice model. METHODS: We have synthesized NIR/red dually fluorescent silica nanoparticles of 19nm covalently covered by a PEG layer of different grafting density in the brush conformational regime by using a reductive amination reaction...
February 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28178597/determination-of-topiramate-in-dried-blood-spots-using-single-quadrupole-gas-chromatography-mass-spectrometry-after-flash-methylation-with-trimethylanilinium-hydroxide
#19
Roberta Zilles Hahn, Marina Venzon Antunes, Priscila Costa Arnhold, Natalia Bordin Andriguetti, Simone Gasparin Verza, Rafael Linden
Dried blood spots (DBS) sampling obtained from fingerpricks is a promising and patient friendly alternative for obtaining samples for drug quantification, that could be of interest for topiramate (TOP) therapeutic drug monitoring. The aim of this study was to develop and validate a simple and fast GC-MS assay for TOP measurement in dried blood spots (DBS). The method uses a liquid extraction of one 8mm DBS, followed by a flash methylation with TMAH, and separation in a DB-5ms capillary column. Total analytical run time was 15min...
February 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28177339/in-situ-spectroscopic-monitoring-of-co2-reduction-at-copper-oxide-electrode
#20
Liying Wang, Kalyani Gupta, Josephine B M Goodall, Jawwad A Darr, Katherine B Holt
Copper oxide modified electrodes were investigated as a function of applied electrode potential using in situ infrared spectroscopy and ex situ Raman and X-ray photoelectron spectroscopy. In deoxygenated KHCO3 electrolyte bicarbonate and carbonate species were found to adsorb to the electrode during reduction and the CuO was reduced to Cu(i) or Cu(0) species. Carbonate was incorporated into the structure and the CuO starting material was not regenerated on cycling to positive potentials. In contrast, in CO2 saturated KHCO3 solution, surface adsorption of bicarbonate and carbonate was not observed and adsorption of a carbonato-species was observed with in situ infrared spectroscopy...
February 8, 2017: Faraday Discussions
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