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Saturation monitoring

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https://www.readbyqxmd.com/read/29344301/wst11-vascular-targeted-photodynamic-therapy-effect-monitoring-by-multispectral-optoacoustic-tomography-msot-in-mice
#1
Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A Coleman, Moritz F Kircher, Vasilis Ntziachristos
Objective: Monitoring emerging vascular-targeted photodynamic therapy (VTP) and understanding the time-dynamics of treatment effects remains challenging. We interrogated whether handheld multispectral optoacoustic tomography (MSOT) could noninvasively monitor the effect of VTP using WST11, a vascular-acting photosensitizer, on tumor tissues over time using a renal cell cancer mouse model. We also investigated whether MSOT illumination can induce VTP, to implement a single-modality theranostic approach. Materials and Methods: Eight BalB/c mice were subcutaneously implanted with murine renal adenocarcinoma cells (RENCA) on the flank...
2018: Theranostics
https://www.readbyqxmd.com/read/29343048/physiology-intervention-and-outcome-three-critical-questions-about-cerebral-tissue-oxygen-saturation-monitoring
#2
Lingzhong Meng, Shaun E Gruenbaum, Feng Dai, Tianlong Wang
The balance between cerebral tissue oxygen consumption and supply can be continuously assessed by cerebral tissue oxygen saturation (SctO2) monitor. A construct consisting of three sequential questions, targeting the physiology monitored, the intervention implemented, and the outcomes affected, is proposed to critically appraise this monitor. The impact of the SctO2- guided care on patient outcome was examined through a systematic literature search and meta- analysis. We concluded that the physiology monitored by SctO2 is robust and dynamic, fragile (prone to derangement), and adversely consequential when deranged...
January 17, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29343016/-effectiveness-and-safety-in-bronchoscopy-under-anesthesia-with-fentanyl-combined-with-midazolam
#3
Z M Luo, H Xiao, J Yuan
Objective: To study the effectiveness and safety in bronchoscopy under anesthesia with fentanyl combined with midazolam. Methods: We randomly allocated 132 patients( male 69, female 63, median age 62.9 years)requiring bronchoscopy in Beijing Xuanwu Hospital into 2 groups during January 2015 to December 2016.The trial group included 66 patients, receiving fentanyl combined with midazolam for anesthesia, while the control group of 66 patients receiving 2% lidocaine for topical anesthesia.In the trial group, there were 37 males and 29 females, with a median age of 63 years (range 26-82)...
January 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29342097/time-domain-near-infrared-spectroscopy-device-for-monitoring-muscle-oxidative-metabolism-custom-probe-and-in-vivo-applications
#4
Rebecca Re, Ileana Pirovano, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli
Measurement of muscle oxidative metabolism is of interest for monitoring the training status in athletes and the rehabilitation process in patients. Time domain near infrared spectroscopy (TD NIRS) is an optical technique that allows the non-invasive measurement of the hemodynamic parameters in muscular tissue: concentrations of oxy- and deoxy-hemoglobin, total hemoglobin content, and tissue oxygen saturation. In this paper, we present a novel TD NIRS medical device for muscle oxidative metabolism. A custom-printed 3D probe, able to host optical elements for signal acquisition from muscle, was develop for TD NIRS in vivo measurements...
January 17, 2018: Sensors
https://www.readbyqxmd.com/read/29341020/mri-in-the-study-of-animal-models-of-stroke
#5
Pedro Ramos-Cabrer, Daniel Padro
Stroke consists of the loss of cerebral functions resulting from the interruption of blood supply to a region of the brain, and represents the second cause of death and the leading cause of major disability in adults in Europe. Stroke is a very active field of research at preclinical and clinical levels, and Magnetic Resonance Imaging (MRI) is one of the most powerful tools that scientist and clinicians have for the study of the onset, evolution and consequences of this devastating disease, as well as for the monitoring of the success of available treatments, or for the development of novel therapeutic strategies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29339617/characteristics-of-n2o-production-and-hydroxylamine-variation-in-short-cut-nitrification-sbr-process
#6
Bo Hu, Junhong Ye, Jianqiang Zhao, Xiaoqian Ding, Liwei Yang, Xiaolei Tian
In order to study the characteristics of nitrous oxide (N2O) production and hydroxylamine (NH2OH) variation under oxic conditions, concentrations of NH2OH and N2O were simultaneously monitored in a short-cut nitrification sequencing batch reactor (SBR) operated with different influent ammonia concentrations. In the short-cut nitrification process, N2O production was increased with the increasing of ammonia concentration in influent. The maximum concentrations of dissolved N2O-N in the reactor were 0.11 mg/L and 0...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29338833/clinical-application-and-development-of-near-infrared-spectroscopy-for-monitoring-regional-cerebral-oxygen-saturation
#7
Hong Yi Li, Xiao Wen Liu, Jing Zhao
The near-infrared spectroscopy has been applied to the continuous and noninvasive monitoring of regional cerebral oxygen saturation,providing information about the equilibrium between cerebral oxygen supply and consumption. This article reviews the mechanism,clinical application,and limitations of this technique.
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29338821/factors-influencing-regional-cerebral-oxygen-saturation-during-one-lung-ventilation-in-thoracic-surgery
#8
Ya Hong Gong, Wei Jia Wang, Wei Wei, Yu Guang Huang
Objective To identify factors influencing regional cerebral oxygen saturation (rScO2) during one-lung ventilation (OLV) in thoracic surgery. Methods Totally 33 patients with an ASA physical status of 1-3 scheduled for elective thoracic surgery with one-lung ventilation under general anesthesia were recruited. After anesthesia was induced with propofol,fentanyl/sufentanil,and rocuronium. All patients received balanced anesthesia using sevoflurane. During OLV,volume-controlled ventilation was used with a tidal volume of 6-7 ml/kg and an inspiration:expiration ratio of 1:1...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29338145/association-between-bispectral-index-system-bistm-and-airway-obstruction-an-observational-prospective-cohort-analysis-during-third-molar-extractions
#9
A Sassan Sabouri, Alireza Jafari, Paul Creighton, Adam Shepherd, Timothy J Votta, Hao Deng, Christopher Heard
BACKGROUND: Sedation regimes during oral procedures frequently associated with airway obstruction. The aim of this study was to define the association of bispectral index (BIS) to the depth of sedation and airway obstruction events. METHODS: 47 patients between 1421 years old who were candidates for 3rd molar teeth extraction were enrolled in this study. Patients received a total of 4mg midazolam, 100 microgram fentanyl followed by titrated incremental propofol in 10mg...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29336556/linking-spectral-induced-polarization-sip-and-subsurface-microbial-processes-results-from-sand-column-incubation-experiments
#10
Adrian Mellage, Christina M Smeaton, Alex Furman, Estella Atekwana, Fereidoun Rezanezhad, Philippe Van Cappellen
Geophysical techniques, such as Spectral Induced Polarization (SIP), offer potentially powerful approaches for in-situ monitoring of subsurface biogeochemistry. The successful implementation of these techniques as monitoring tools for reactive transport phenomena, however, requires the de-convolution of multiple contributions to measured signals. Here, we present SIP spectra and complementary biogeochemical data obtained in saturated columns packed with alternating layers of ferrihydrite-coated and pure quartz sand, and inoculated with Shewanella oneidensis supplemented with lactate and nitrate...
January 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29332575/protective-role-of-italian-juglans-regia-l-nut-ethanolic-extract-in-human-keratinocytes-under-oxidative-and-inflammatory-stress
#11
Cinzia Calcabrini, Umberto Mancini, Roberta De Bellis, Alessandra Frati, Anna Rita Mastrogiacomo, Giosue Annibalini, Piero Sestili, Luigi Cucchiarini, Vilberto Stocchi, Lucia Potenza
OBJECTIVE: In this research, fatty acid profile and polyphenolic content of an ethanolic extract of walnut from Juglans regia L. collected in Central Italy, were performed. The potential antioxidant and anti-inflammatory effects of the extract were investigated in the human keratinocytes cell line. METHODS: Fatty acid profile was determined by gas chromatography/mass spectrometry analysis, total phenolic content by Folin-Ciocalteu method and aluminum chloride colorimetric method was used for determination of total flavonoids...
January 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29330639/changes-in-tissue-and-cerebral-oxygenation-following-spinal-anesthesia-in-infants-a-prospective-study
#12
Alexander B Froyshteter, Dmitry Tumin, Emmett E Whitaker, David P Martin, Mumin Hakim, Hina Walia, Tarun Bhalla, Joseph D Tobias
Use of spinal anesthesia (SA) in children may address concerns about potential neurocognitive effects of general anesthesia. We used near-infrared spectroscopy (NIRS) to assess the effects of SA on cerebral and tissue oxygenation in 19 patients aged 7 ± 3 months. Prior to SA placement, NIRS monitors were placed on the forehead (cerebral) and the thigh (tissue). Intraoperative cerebral and tissue saturation were 73 ± 7 and 80 ± 11%, respectively, before SA placement. NIRS measurements were monitored every minute for 30 min after SA placement and modeled using mixed-effects linear regression...
January 12, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29325335/-association-between-serum-adipocyte-fatty-acid-binding-protein-level-and-insulin-resistance-in-patients-with-osas
#13
Y B Wang, X F Li, R Chen, J H Shen, Y H Zhang
Objective: To investigate the association between serum adipocyte fatty acid binding protein (A-FABP) level and insulin resistance in patients with obstructive sleep apnea syndromes (OSAS). Methods: Eighty patients with snoring were monitored by overnight polysomnography (PSG) from September 2015 to July 2017, and there were 59 males and 21 females, aged from 22 to 77 years old (mean age 47±14 years old). Based on the apnea-hypopnea index (AHI), these patients were divided into three groups: primary snoring group (AHI<5/h, n=19), mild-moderate OSAS groups (5/h≤AHI≤30/h, n=23) and severe OSAS groups (AHI>30/h, n=38)...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29324643/nutritional-status-of-bariatric-surgery-candidates
#14
Aliaa Al-Mutawa, Alfred Kojo Anderson, Salman Alsabah, Mohammad Al-Mutawa
Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29324491/validation-of-a-second-generation-near-infrared-spectroscopy-monitor-in-children-with-congenital-heart-disease
#15
Viviane G Nasr, Lisa T Bergersen, Hung-Mo Lin, Paul B Benni, Rachel S Bernier, Michelle E Anderson, Barry D Kussman
BACKGROUND: Cerebral oximetry using near-infrared spectroscopy is a noninvasive optical technology to detect cerebral hypoxia-ischemia and develop interventions to prevent and ameliorate hypoxic brain injury. Cerebral oximeters are calibrated and validated by comparison of the near-infrared spectroscopy-measured cerebral O2 saturation (SctO2) to a "field" or reference O2 saturation (REF CX) calculated as a weighted average from arterial and jugular bulb oxygen saturations. In this study, we calibrated and validated the second-generation, 5 wavelength, FORE-SIGHT Elite with the medium sensor (source-detector separation 12 and 40 mm) for measurement of SctO2 in children with congenital heart disease...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29321898/sap-flow-characteristics-and-responses-to-summer-rainfall-for-pinus-tabulaeformis-and-hippophae-rhamnoides-in-the-loess-hilly-region-of-china
#16
Xu Wu, Yakun Tang, Yunming Chen, Jie Wen, Yuli Xie, Senbao Lu
As a major driving element of the structure and function of arid and semiarid ecosystems, rainfall is the essential factor limiting plant biological processes. To clarify the characteristics of transpiration and responses to summer rainfall, sap flow density (Fd) of Pinus tabulaeformis and Hippophae rhamnoides was monitored using thermal dissipation probes. In addition, midday leaf water potential (ψm) and leaf stomatal conductance (Gs) were also analyzed to determine water use strategies. The results indicated that the diurnal variation in the normalized Fd values exhibited a single-peak curve for P...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321408/the-factors-affecting-the-non-dipper-pattern-in-japanese-patients-with-severe-obstructive-sleep-apnea
#17
Hiromitsu Sekizuka, Naohiko Osada, Yoshihiro J Akashi
Objective Obstructive sleep apnea (OSA) is assumed to influence the circadian blood pressure (BP) fluctuation, particularly causing nocturnal hypertension and changing the dipping pattern of nocturnal BP. This study aimed to clarify the triggers of the non-dipper pattern in nocturnal BP in Japanese patients with severe OSA (the apnea-hypopnea index ≥30/h). Methods Of 541 patients with OSA diagnosed using polysomnography (PSG) and ambulatory BP monitoring (ABPM), 163 patients <60 years of age (Younger group) and 101 patients ≥60 years of age (Older group) were stratified into the dipper or non-dipper pattern groups...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29318099/a-small-molecule-impedes-insulin-fibrillation-another-new-role-of-phenothiazine-derivatives
#18
Meghomukta Mukherjee, Jagannath Jana, Subhrangsu Chatterjee
Protein misfolding is interrelated to several diseases, including neurodegenerative diseases and type II diabetes. Misfolded/unfolded proteins produce soluble oligomers that accumulate into "amyloid plaques". Inhibition of amyloid-plaque formation by those misfolded/unfolded proteins will lead to the invention of new therapeutic approaches for amyloid-related diseases. Herein, methylene blue (MB), a well-defined drug against multiple diseases and disorders, is used to impede insulin fibrillation. In this study, we perform an array of in vitro experiments to monitor the effects of MB on the fibrillation of bovine insulin...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29314868/bronchiolitis-obliterans-and-pulmonary-fibrosis-after-sulfur-mustard-inhalation-in-rats
#19
Matthew D McGraw, Marilyn M Dysart, Tara B Hendry-Hofer, Paul R Houin, Jacqueline S Rioux, Rhonda B Garlick, Joan E Loader, Russell Smith, Danielle C Paradiso, Wesley W Holmes, Dana R Anderson, Carl W White, Livia A Veress
RATIONALE: Inhalation of powerful chemical agents, such as sulfur mustard (SM), can have debilitating pulmonary consequences, such as bronchiolitis obliterans (BO) and parenchymal fibrosis (PF). The underlying pathogenesis of disorders after SM inhalation is not clearly understood, resulting in a paucity of effective therapies. OBJECTIVE: To evaluate the role of pro-fibrotic pathways involving TGF-β and PDGF in the development of BO and PF after inhalation injury sustained by SM, using a rat model...
January 9, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29314858/panitumumab-modified-with-metal-chelating-polymers-mcp-complexed-to-111in-and-177lu-an-egfr-targeted-theranostic-for-pancreatic-cancer
#20
Sadaf Aghevlian, Yijie Lu, Mitchell A Winnik, David W Hedley, Raymond M Reilly
A metal-chelating polymer (MCP) with a polyglutamide (PGlu) backbone presenting on average 13 DOTA (tetraazacyclododecane-1,4,7,10-tetraacetic acid) chelators for complexing 111In or 177Lu and 10 polyethylene glycol (PEG) chains to minimize liver and spleen uptake was conjugated to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), panitumumab. Since panitumumab-MCP may be dual-labeled with 111In and 177Lu for SPECT, or radioimmunotherapy (RIT) exploiting the Auger electrons or β-particle emissions, respectively, we propose that panitumumab-MCP could be a useful theranostic agent EGFR-positive PnCa...
January 9, 2018: Molecular Pharmaceutics
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