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https://www.readbyqxmd.com/read/28734206/theoretical-investigation-of-the-conformational-space-of-baicalin
#1
Juan J Martínez Medina, Evelina G Ferrer, Patricia A M Williams, Nora B Okulik
Flavonoids are a large group of polyphenolic compounds ubiquitously present in plants. They are important components of human diet. They are recognized as potential drug candidates to be used in the treatment and prevention of a lot of pathological disorders, due to their protective effects. Baicalin (7-glucuronic acid 5, 6-dihydroxyflavone) is one of the main single active constituents isolated from the dried roots of Scutellaria baicalensis Georgi. The great interest on this flavonoid is due to its various pharmacological properties, such as antioxidant, antimicrobial, anti-inflammatory, anticancer and so on, and its high accumulation in the roots of S...
July 11, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28716570/protective-effects-of-pistacia-lentiscus-l-fruit-extract-against-calcium-oxalate-monohydrate-induced-proximal-tubular-injury
#2
Nassima Cheraft-Bahloul, Cécile Husson, Meriam Ourtioualous, Sébastien Sinaeve, Djebbar Atmani, Caroline Stévigny, Joëlle L Nortier, Marie-Hélène Antoine
ETHNOPHARMACOLOGICAL RELEVANCE: The world prevalence of kidney stones is increasing and plants are frequently used to treat urolithiasis. Pistacia lentiscus L, a plant which freely grows around the Mediterranean basin areas, is widely used for various pathologies. P. lentiscus has an important impact as it has economical value on top of its pharmacological interest. Decoctions of its aerial parts and/or resin are used to treat kidney stones. AIM OF THE STUDY: To in vitro assess the potential nephroprotective effect of Pistacia lentiscus ethanolic fruit extract (PLEF) on proximal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals...
July 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28715960/histone-methylation-by-set-domain-proteins-in-fungi
#3
Michael Freitag
Histone-modifying enzymes are responsible for regulating transcription, recombination, DNA repair, DNA replication, chromatid cohesion, and chromosome segregation. Fungi are ideally suited for comparative chromatin biology because sequencing of numerous genomes from many clades is coupled to existing rich methodology that allows truly holistic approaches, integrating evolutionary biology with mechanistic molecular biology and ecology, promising applications in medicine or plant pathology. While genome information is rich, mechanistic studies on histone modifications are largely restricted to two yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and one filamentous fungus, Neurospora crassa-three species that arguably are not representative of this diverse kingdom...
July 17, 2017: Annual Review of Microbiology
https://www.readbyqxmd.com/read/28713575/wildlife-hosts-for-oie-listed-diseases-considerations-regarding-global-wildlife-trade-and-host-pathogen-relationships
#4
Kristine M Smith, Catherine M Machalaba, Hilary Jones, Paula Cáceres, Marija Popovic, Kevin J Olival, Karim Ben Jebara, William B Karesh
The expanding international wildlife trade, combined with a lack of surveillance for key animal diseases in most countries, represents a potential pathway for transboundary disease movement. While the international wildlife trade represents over US $300 billion per year industry involving exchange of billions of individual animals, animal products, and plants as traditional medicines, meat from wild animals, trophies, live exotic pets, commercial products and food, surveillance and reporting of OIE-Listed diseases in wildlife are often opportunistic...
May 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/28711031/the-sinomenine-enteric-coated-microspheres-suppressed-the-tlr-nf-%C3%AE%C2%BAb-signaling-in-dss-induced-experimental-colitis
#5
Huifang Xiong, Liang Tian, Zihan Zhao, Shuping Chen, Qiaoyun Zhao, Junbo Hong, Yong Xie, Nanjin Zhou, Yingjun Fu
Sinomenine is a pure alkaloid with immunosuppressive effects that is extracted from the Chinese medicinal plant Sinomenium acutum. We studied the therapeutic effects of sinomenine on inflammatory bowel disease. In this study, we randomly divided mice into the following ten groups: Control group; DSS-induced colitis group; Salicylazosulfapyridine (SASP)-treated group; Chitosan-treated group; low-, medium-, and high-dose sinomenine-treated and sinomenine enteric-coated microspheres-treated groups. We recorded changes in colon length, disease activity index (DAI), and colon pathology, measured TLR4, MyD88, SIGIRR, NF-κB p65 protein levels and inflammatory serum cytokine levels...
July 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28701733/endosomal-nox2-oxidase-exacerbates-virus-pathogenicity-and-is-a-target-for-antiviral-therapy
#6
Eunice E To, Ross Vlahos, Raymond Luong, Michelle L Halls, Patrick C Reading, Paul T King, Christopher Chan, Grant R Drummond, Christopher G Sobey, Brad R S Broughton, Malcolm R Starkey, Renee van der Sluis, Sharon R Lewin, Steven Bozinovski, Luke A J O'Neill, Tim Quach, Christopher J H Porter, Doug A Brooks, John J O'Leary, Stavros Selemidis
The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that protect plants, fungi and animals against invading pathogens including bacteria. However, in mammals reactive oxygen species production paradoxically promotes virus pathogenicity by mechanisms not yet defined. Here we identify that the primary enzymatic source of reactive oxygen species, NOX2 oxidase, is activated by single stranded RNA and DNA viruses in endocytic compartments resulting in endosomal hydrogen peroxide generation, which suppresses antiviral and humoral signaling networks via modification of a unique, highly conserved cysteine residue (Cys98) on Toll-like receptor-7...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28700665/solution-conformations-of-zika-ns2b-ns3pro-and-its-inhibition-by-natural-products-from-edible-plants
#7
Amrita Roy, Liangzhong Lim, Shagun Srivastava, Yimei Lu, Jianxing Song
The recent Zika viral (ZIKV) epidemic has been associated with severe neurological pathologies such as neonatal microcephaly and Guillain-Barre syndrome but unfortunately no vaccine or medication is effectively available yet. Zika NS2B-NS3pro is essential for the proteolysis of the viral polyprotein and thereby viral replication. Thus NS2B-NS3pro represents an attractive target for anti-Zika drug discovery/design. Here, we have characterized the solution conformations and catalytic parameters of both linked and unlinked Zika NS2B-NS3pro complexes and found that the unlinked complex manifested well-dispersed NMR spectra...
2017: PloS One
https://www.readbyqxmd.com/read/28700433/data-set-for-the-reporting-of-carcinomas-of-the-cervix-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#8
W Glenn McCluggage, Meagan J Judge, Isabel Alvarado-Cabrero, Máire A Duggan, Lars-Christian Horn, Pei Hui, Jaume Ordi, Christopher N Otis, Kay J Park, Marie Plante, Colin J R Stewart, Edwin K Wiredu, Brian Rous, Lynn Hirschowitz
A comprehensive pathologic report is essential for optimal patient management, cancer staging and prognostication. In many countries, proforma reports are used but the content of these is variable. The International Collaboration on Cancer Reporting is an alliance formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Partnership Against Cancer and the European Society of Pathology, for the purpose of developing standardized, evidence-based reporting data sets for each cancer site...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28694778/north-african-medicinal-plants-traditionally-used-in-cancer-therapy
#9
REVIEW
Jorge M Alves-Silva, Abderrahmane Romane, Thomas Efferth, Lígia Salgueiro
Background: Cancer is a major cause of mortality worldwide with increasing numbers by the years. In North Africa, the number of cancer patients is alarming. Also shocking is that a huge number of cancer patients only have access to traditional medicines due to several factors, e.g., economic difficulties. In fact, medicinal plants are widely used for the treatment of several pathologies, including cancer. Truthfully, herbalists and botanists in North African countries prescribe several plants for cancer treatment...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28677479/testing-differences-between-pathogen-compositions-with-small-samples-and-sparse-data
#10
Samuel Soubeyrand, Vincent Garetta, Caroline Monteil, Frederic Suffert, Henriette Goyeau, Julie Berder, Jacques Moinard, Elisabeth Fournier, Didier Bs Tharreau, Cindy Morris, Ivan Sache
The structure of pathogen populations is an important driver of epidemics affecting crops and natural plant communities. Comparing the composition of two pathogen populations consisting of assemblages of genotypes or phenotypes is a crucial, recurrent question encountered in many studies in plant disease epidemiology. Determining if there is a significant difference between two sets of proportions is also a generic question for numerous biological fields. When samples are small and data are sparse, it is not straightforward to provide an accurate answer to this simple question because routine statistical tests may not be exactly calibrated...
July 5, 2017: Phytopathology
https://www.readbyqxmd.com/read/28671960/stress-fibers-autophagy-and-necrosis-by-persistent-exposure-to-pm2-5-from-biomass-combustion
#11
Regina Dornhof, Christoph Maschowski, Anastasiya Osipova, Reto Gieré, Maximilian Seidl, Irmgard Merfort, Matjaz Humar
Fine particulate matter (PM2.5) can adversely affect human health. Emissions from residential energy sources have the largest impact on premature mortality globally, but their pathological and molecular implications on cellular physiology are still elusive. In the present study potential molecular consequences were investigated during long-term exposure of human bronchial epithelial BEAS-2B cells to PM2.5, collected from a biomass power plant. Initially, we observed that PM2.5 did not affect cellular survival or proliferation...
2017: PloS One
https://www.readbyqxmd.com/read/28671623/plant-lectins-as-medical-tools-against-digestive-system-cancers
#12
REVIEW
Laura Elena Estrada-Martínez, Ulisses Moreno-Celis, Ricardo Cervantes-Jiménez, Roberto Augusto Ferriz-Martínez, Alejandro Blanco-Labra, Teresa García-Gasca
Digestive system cancers-those of the esophagus, stomach, small intestine, colon-rectum, liver, and pancreas-are highly related to genetics and lifestyle. Most are considered highly mortal due to the frequency of late diagnosis, usually in advanced stages, caused by the absence of symptoms or masked by other pathologies. Different tools are being investigated in the search of a more precise diagnosis and treatment. Plant lectins have been studied because of their ability to recognize and bind to carbohydrates, exerting a variety of biological activities on animal cells, including anticancer activities...
July 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28669749/extracellular-vesicles-in-gastrointestinal-cancer-in-conjunction-with-microbiota-on-the-border-of-kingdoms
#13
REVIEW
Natasha S Barteneva, Yeldar Baiken, Elizaveta Fasler-Kan, Kenneth Alibek, Sheng Wang, Natalia Maltsev, Eugeny D Ponomarev, Zarina Sautbayeva, Sholpan Kauanova, Anna Moore, Christoph Beglinger, Ivan A Vorobjev
Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicls). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations...
June 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28666461/glyceollins-trigger-anti-proliferative-effects-through-estradiol-dependent-and-independent-pathways-in-breast-cancer-cells
#14
Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou, Farzad Pakdel
BACKGROUND: Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract. In addition to estradiol (E2), a natural hormone, numerous compounds are able to bind ERs and modulate their activities. Among these compounds, phytoestrogens such as isoflavones, which are found in plants, are promising therapeutics for several pathologies. Glyceollins are second metabolites of isoflavones that are mainly produced in soybean in response to an elicitor...
June 30, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28653916/biological-activities-of-allium-sativum-and-zingiber-officinale-extracts-on-clinically-important-bacterial-pathogens-their-phytochemical-and-ft-ir-spectroscopic-analysis
#15
Uzma Azeem Awan, Shaukat Ali, Amna Mir Shahnawaz, Irsa Shafique, Atiya Zafar, Muhammad Abdul Rauf Khan, Tahseen Ghous, Azhar Saleem, Saiqa Andleeb
The spread of bacterial infectious diseases is a major public threat. Herbs and spices have offered an excellent, important and useful source of antimicrobial agents against many pathological infections. In the current study, the antimicrobial potency of fresh, naturally and commercial dried Allium sativum and Zingiber officinale extracts had been investigated against seven local clinical bacterial isolates such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus epidermidis, and Serratia marcesnces by the agar disc diffusion method...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28652141/andrographolide-loaded-nanoparticles-for-brain-delivery-formulation-characterisation-and-in-vitro-permeability-using-hcmec-d3-cell-line
#16
Clizia Guccione, Mouhssin Oufir, Vieri Piazzini, Daniela Elisabeth Eigenmann, Evelyn Andrea Jähne, Volha Zabela, Maria Teresa Faleschini, Maria Camilla Bergonzi, Martin Smiesko, Matthias Hamburger, Anna Rita Bilia
Andrographolide (AG) is a major diterpenoid of the Asian medicinal plant Andrographis paniculata which has shown exciting pharmacological potential for the treatment of inflammation-related pathologies including neurodegenerative disorders. Conversely, the low bioavailability of AG still represents a limiting factor for its use. To overcome these limitations, AG was loaded into human serum albumin based nanoparticles (HSA NPs) and poly ethylcyanoacrylate nanoparticles (PECA NPs). HSA NPs were prepared by thermal (HSAT AG NPs) and chemical cross-linking (HSAC AG NPs), while PECA AG NPs were produced by emulsion-polymerization...
June 23, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28643520/main-plant-extracts-active-properties-effective-on-scopolamine-induced-memory-loss
#17
Ioana-Miruna Balmus, Alin Ciobica
Alzheimer's disease leads to progressive cognitive function loss, which may impair both intellectual capacities and psychosocial aspects. Although the current knowledge points to a multifactorial character of Alzheimer's disease, the most issued pathological hypothesis remains the cholinergic theory. The main animal model used in cholinergic theory research is the scopolamine-induced memory loss model. Although, in some cases, a temporary symptomatic relief can be obtained through targeting the cholinergic or glutamatergic neurotransmitter systems, no current treatment is able to stop or slow cognitive impairment...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28641164/protective-effects-of-flavonoids-against-alzheimer-s-disease-related-neural-dysfunctions
#18
REVIEW
Mahsa Bakhtiari, Yunes Panahi, Javad Ameli, Behrad Darvishi
Senile ages of human life is mostly associated with developmental of several neurological complicated conditions including decreased cognition and reasoning, increased memory loss and impaired language performance. Alzheimer's disease (AD) is the most prevalent neural disorder associated with dementia, consisting of about 70% of dementia reported cases. Failure of currently approved chemical anti-AD therapeutic agents has once again brought up the idea of administering naturally occurring compounds as effective alternative and/or complementary regimens in AD treatment...
June 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28638888/modulation-of-key-biochemical-markers-relevant-to-stroke-by-antiaris-africana-leaf-extract-following-cerebral-ischemia-reperfusion-injury
#19
Omotayo B Ilesanmi, Afolabi C Akinmoladun, Olanrewaju Sam Olayeriju, Ibrahim Olabayode Saliu, M Tolulope Olaleye, Afolabi A Akindahunsi
BACKGROUND: Oxidative stress plays a significant role in stroke pathogenesis. Hence, plants rich in antioxidant phytochemicals have been suggested as effective remedies for prevention and treatment of stroke and other neurological diseases. Antiaris africana Engl. (Moraceae) is traditionally used for the management of brain-related problems but there is paucity of data on its anti-stroke potential. MATERIALS AND METHODS: Ischemia/reperfusion injury was induced by a 30 min bilateral common carotid artery occlusion/ 2 h reperfusion (BCCAO/R) in the brain of male Wistar rats...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28628020/-study-of-cytotoxic-activity-of-methanol-extracts-of-the-endemic-plant-of-the-genus-erysimum-of-the-adjarian-floristic-district-of-georgia
#20
D Beridze, M Metreveli, M Joxadze, K Bakuridze, D Berashvili, A Bakuridze
According to the results, investigated methanolic extracts of endemic plant from Adjarian floristic region of Georgia do not have specific cytotoxicity against the cell lines of breast adenocarcinoma MCF-7 human, which is typical, e.g., for plant pigment curcumin. At the same time, the high specific cytotoxicity of 2 and 3 fractions towards keratinocytes gives reason for considering endemic plant extracts, of Adjarian floristic region of Georgia, as a potential pharmacological means for topical treatment of pathologies caused by increased proliferation of keratinocytes, such as psoriasis...
May 2017: Georgian Medical News
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