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https://www.readbyqxmd.com/read/29243580/coumarins-as-promising-scaffold-for-the-treatment-of-age-related-diseases-an-overview-of-the-last-five-years
#1
Giovanna Lucia Delogu, Maria Joao Matos
Degenerative diseases are becoming increasingly prevalent with the aging of the human population. The twentieth century witnessed a significant demographic change in the industrialized world that is currently followed by a similar shift of life expectancy to upper age ranges in Asia, Africa, and Middle and South America. A rising tide of chronic age-dependent diseases will soon present serious challenges for these countries. Age-related diseases are commonly seen in older patients. More than 40% of adults 60 and older have a combination of risk factors known as metabolic syndrome, which increases the risk for developing degenerative disorders, and certain cancers...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29243291/antiinflammatory-properties-of-betulinic-acid-and-xylopic-acid-in-the-carrageenan-induced-pleurisy-model-of-lung-inflammation-in-mice
#2
Edmund Ekuadzi, Robert P Biney, Charles K Benneh, Bismark Osei Amankwaa, Jonathan Jato
This study investigated the antiinflammatory properties of betulinic acid (BA) and xylopic acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. M. discoidea and X. aethiopica are plants native in Ghana and the West-African region and used traditionally to treat different pathologies including inflammatory conditions. The antiinflammatory effect of BA and XA was established by an in vivo assay using the carrageenan-induced pleural inflammation model in mice. Also, the ability of BA and XA to increase catalase, superoxide dismutase, glutathione levels and decrease lipid peroxidation level in reactive oxidative assays was assessed...
December 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29241917/pueraria-mirifica-inhibits-17%C3%AE-estradiol-induced-cell-proliferation-of%C3%A2-human-endometrial-mesenchymal-stem-cells
#3
Ta-Chin Lin, Kai-Hung Wang, An-Pei Kao, Kuo-Hsiang Chuang, Tsung-Cheng Kuo
OBJECTIVE: The notion that the human endometrium may contain a population of stem cells has recently been proposed. The mesenchymal stem cells (MSCs) in the endometrium are believed to be responsible for the remarkable regenerative ability of endometrial cells. Estrogens influence the physiological and pathological processes of several hormone-dependent tissues, such as the endometrium. Pueraria mirifica (PM) is a herbal plant that contains several phytoestrogens, including isoflavones, lignans, and coumestans, and is known to exert an estrogenic effect on animal models...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29238276/computer-aided-drug-discovery-in-plant-pathology
#4
REVIEW
Gnanendra Shanmugam, Junhyun Jeon
Control of plant diseases is largely dependent on use of agrochemicals. However, there are widening gaps between our knowledge on plant diseases gained from genetic/mechanistic studies and rapid translation of the knowledge into target-oriented development of effective agrochemicals. Here we propose that the time is ripe for computer-aided drug discovery/design (CADD) in molecular plant pathology. CADD has played a pivotal role in development of medically important molecules over the last three decades. Now, explosive increase in information on genome sequences and three dimensional structures of biological molecules, in combination with advances in computational and informational technologies, opens up exciting possibilities for application of CADD in discovery and development of agrochemicals...
December 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/29230098/circular-rnas-a-novel-type-of-non-coding-rna-and-their-potential-implications-in-antiviral-immunity
#5
REVIEW
Man Wang, Fei Yu, Wei Wu, Yuan Zhang, Wenguang Chang, Murugavel Ponnusamy, Kun Wang, Peifeng Li
Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), are ubiquitously expressed in eukaryotic cells during post-transcriptional processes. Unlike linear RNAs, circRNAs form covalent-closed continuous loops without 5' to 3' polarities and poly (A) tails. With advances in high-throughput sequencing technology, numerous circRNAs have been identified in plants, animals and humans. Notably, circRNAs display cell-type, tissue-type and developmental-stage specific expression patterns in eukaryotic transcriptome, which reveals their significant regulatory functions in gene expression...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29222042/antiangiogenic-compounds-well-established-drugs-versus-emerging-natural-molecules
#6
Andreia Ribeiro, Rui M V Abreu, Madalena M Dias, Maria Filomena Barreiro, Isabel C F R Ferreira
Angiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesis-related pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs...
December 5, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29210634/preventive-and-therapeutic-potentials-of-anthocyanins-in-diabetes-and-associated-complications
#7
Swathi Putta, Nagendra Sastry Yarla, Eswar K Kumar, Dhananjaya Bhadrapura Lakkappa, Mohammad A Kamal, Luciana Scotti, Marcus T Scotti, Ghulam Md Ashraf, George E Barreto, B Sasi Bhusana Rao, D Sarala Kumari, Gorla V Reddy, Vadim V Tarasov, Sarat Babu Imandi, Gjumrakch Aliev
Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, it is to be considering the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29205105/epidemiology-past-present-and-future-impacts-on-understanding-disease-dynamics-and-improving-plant-disease-management-a-summary-of-focus-issue-articles
#8
P S Ojiambo, J Yuen, F van den Bosch, L V Madden
Epidemiology has made significant contributions to plant pathology by elucidating the general principles underlying the development of disease epidemics. This has resulted in a greatly improved theoretical and empirical understanding of the dynamics of disease epidemics in time and space, predictions of disease outbreaks or the need for disease control in real-time basis, and tactical and strategic solutions to disease problems. Availability of high-resolution experimental data at multiple temporal and spatial scales has now provided a platform to test and validate theories on the spread of diseases at a wide range of spatial scales ranging from the local to the landscape level...
October 2017: Phytopathology
https://www.readbyqxmd.com/read/29203327/ros-induced-ros-release-in-plant-and-animal-cells
#9
Sara I Zandalinas, Ron Mittler
Reactive oxygen species (ROS) play a key signaling role in plant and animal cells. Among the many cellular mechanisms used to generate and transduce ROS signals, ROS-induced ROS release (RIRR) is emerging as an important pathway involved in different human pathologies and plant responses to environmental stress. RIRR is a process in which one cellular compartment or organelle generates or releases ROS, triggering the enhanced production or release of ROS by another compartment or organelle. It was initially described in animal cells and proposed to mediate mitochondria-to-mitochondria communication, but later expanded to include communication between mitochondria and plasma membrane-localized NADPH oxidases...
December 1, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29194832/the-pathogenesis-of-paraesophageal-empyema-in-dogs-and-constancy-of-radiographic-and-computed-tomography-signs-are-linked-to-involvement-of-the-mediastinal-serous-cavity
#10
Karine Gendron, Sean P McDonough, James A Flanders, May Tse, Peter V Scrivani
The mediastinal serous cavity is a normal anatomic space in the caudal mediastinum. Aims of this anatomic and case series study were to describe the signs of pathologic expansion of the mediastinal serous cavity observed during computed tomography (CT), review the underlying anatomy, perform a literature review, and evaluate the medical records of several dogs with mediastinal serous cavity empyema (paraesophageal empyema). The mesothelial lined mediastinal serous cavity is a cranial extension of the omental bursa, separated from the peritoneal cavity by the diaphragm, in the dorsal part of the caudal mediastinum, to the right of the esophagus, between the heart base and diaphragm...
November 30, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29182540/probing-protein-glycation-by-chromatography-and-mass-spectrometry-analysis-of-glycation-adducts
#11
REVIEW
Alena Soboleva, Maria Vikhnina, Tatiana Grishina, Andrej Frolov
Glycation is a non-enzymatic post-translational modification of proteins, formed by the reaction of reducing sugars and α-dicarbonyl products of their degradation with amino and guanidino groups of proteins. Resulted early glycation products are readily involved in further transformation, yielding a heterogeneous group of advanced glycation end products (AGEs). Their formation is associated with ageing, metabolic diseases, and thermal processing of foods. Therefore, individual glycation adducts are often considered as the markers of related pathologies and food quality...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29176736/rama-a-machine-learning-approach-for-ribosomal-protein-prediction-in-plants
#12
Thales Francisco Mota Carvalho, José Cleydson F Silva, Iara Pinheiro Calil, Elizabeth Pacheco Batista Fontes, Fabio Ribeiro Cerqueira
Ribosomal proteins (RPs) play a fundamental role within all type of cells, as they are major components of ribosomes, which are essential for translation of mRNAs. Furthermore, these proteins are involved in various physiological and pathological processes. The intrinsic biological relevance of RPs motivated advanced studies for the identification of unrevealed RPs. In this work, we propose a new computational method, termed Rama, for the prediction of RPs, based on machine learning techniques, with a particular interest in plants...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173148/trends-and-prospects-of-plant-proteases-in-therapeutics
#13
Anastasia V Balakireva, Natalia V Kuznetsova, Anastasia I Petushkova, Lyudmila Savvateeva, Andrey A Zamyatnin
The main function of proteases in any living organism is the cleavage of proteins resulting in the degradation of damaged, misfolded and potentially harmful proteins and therefore providing the cell with amino acids essential for the synthesis of new proteins. Besides this main function, proteases may play an important role as signal molecules and participate in numerous protein cascades to maintain the vital processes of an organism. Plant proteases are no exception to this rule. Moreover, in contrast to human-encoded enzymes, many plant proteases possess exceptional features such as higher stability, unique substrate specificity and a wide pH range for enzymatic activity...
November 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29168921/bauhinia-forficata-in-the-treatment-of-diabetes-mellitus-a-patent-review
#14
Bárbara Verônica Cardoso de Souza, Regilda Saraiva Dos Reis Moreira Araújo, Oskar Almeida Silva, Lucas Costa Faustino, Maria Fabrícia Beserra Gonçalves, Mirian Lima Dos Santos, Grasielly Rocha Souza, Lindalva Moura Rocha, Mônica Larissa Sousa Cardoso, Lívio César Cunha Nunes
Diabetes Mellitus has been considered an epidemic by the World Health Organization, with a high risk of morbidity and mortality. The treatment of this pathology consists in glycemic control, which can be done by oral hypoglycemic agents, insulin therapy, dietary guidance, regular physical activity, and psychosocial support. In addition, other adjuvant treatments are employed, such as phytotherapic, and one of the most used plants is Bauhinia forficata. Areas covered: in the current review, patents using Bauhinia forficata for the Diabetes Mellitus treatment have been analyzed...
November 23, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29156537/ursolic-acid-ameliorates-oxidative-stress-inflammation-and-fibrosis-in-diabetic-cardiomyopathy-rats
#15
Xu-Tao Wang, Yan Gong, Bin Zhou, Jun-Jie Yang, Yin Cheng, Jin-Guo Zhao, Min-You Qi
Diabetic cardiomyopathy is a major and severe cardiovascular complication of diabetes mellitus. Ursolic acid, a pentacyclic triterpene compound widespread in fruits and plants, performs a variety of pharmacological activities including lowering blood glucose, anti-oxidation, anti-inflammation and anti-fibrosis. Our present study aimed to investigate the cardioprotective effects of ursolic acid on diabetic cardiomyopathy rats and uncover its underlying mechanism. Diabetes mellitus was induced by a single injection of STZ-only (40 mg/ kg, i...
November 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29147934/an-outbreak-of-poisoning-by-kalanchoe-blossfeldiana-in-cattle-in-northeastern-brazil
#16
Fábio S Mendonça, Naiara C F Nascimento, Valdir M Almeida, Thaiza C Braga, Daniele P Ribeiro, Hisadora A S Chaves, Givaldo B Silva Filho, Franklin Riet-Correa
In the world, Kalanchoe species are primarily ornamentals and houseplants, but some have escaped cultivation and can be found in the field. In Latin America, there are no reports of spontaneous poisoning by Kalanchoe species in animals. This study aimed to describe the epidemiological, clinical, and pathological aspects of an outbreak of poisoning by Kalanchoe blossfeldiana in cattle in the semiarid region of Pernambuco, Brazil. Epidemiological and clinical data were obtained from the owner and veterinarian during technical visits...
November 16, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29140397/progress-in-the-understanding-of-the-pathology-of-allergic-asthma-and-the-potential-of-fruit-proanthocyanidins-as-modulators-of-airway-inflammation
#17
REVIEW
Sara L Coleman, Odette M Shaw
Allergic asthma is a chronic inflammatory lung disease characterized by sensitization of the airways, and the development of immunoglobulin E antibodies, to benign antigens. The established pathophysiology of asthma includes recurrent lung epithelial inflammation, excessive mucus production, bronchial smooth muscle hyperreactivity, and chronic lung tissue remodeling, resulting in reversible airflow restriction. Immune cells, including eosinophils and the recently characterized type 2 innate lymphoid cells, infiltrate into the lung tissue as part of the inflammatory response in allergic asthma...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29137941/acute-and-sub-acute-oral-toxicity-studies-of-the-aqueous-extract-from-radix-radix-with-cortex-and-cortex-of-psammosilene-tunicoides-in-mice-and-rats
#18
Yi-Chen, Min-Xuan Wu, Jie-Liu, Xiao-Jie Ma, Jin-Li Shi, Sheng-Nan Wang, Zhi-Quan Zheng, Jian-You Guo
ETHNOPHARMACOLOGICAL RELEVANCE: Psammosilene tunicoides is one of the important ingredients of a famous Chinese traditional medicine formulation "Yunnan Baiyao". Also, this plant is commonly used as an anodyne and hemostatic agent in southwest China. Currently, little toxicological information is available on its safety following prolonged use. AIM OF THE STUDY: In this study, we sought to evaluate the toxicity of the three different parts of Psammosilene tunicoides: Psammosilenes Radix (PR), Psammosilenes Radix with Cortex (PRC) and Psammosilenes Cortex (PC) by acute and sub-acute toxicity studies...
November 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29128800/beneficial-roles-of-honey-polyphenols-against-some-human-degenerative-diseases-a-review
#19
REVIEW
Md Sakib Hossen, Md Yousuf Ali, M H A Jahurul, Mohamed M Abdel-Daim, Siew Hua Gan, Md Ibrahim Khalil
Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health...
July 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128544/experimental-poisoning-by-vernonia-rubricaulis-in-sheep
#20
Kelly C S Godoy, Paula V Leal, Marcelo A Araújo, Alda I Souza, Arnildo Pott, Stephen T Lee, Claudio S L Barros, Ricardo A A de Lemos
In order to evaluate the susceptibility of sheep to V. rubricaulis and to establish the clinical signs, serum biochemistry, and pathological findings, eight sheep were fed varying doses of V. rubricaulis. The onset of clinical signs occurred 6-48 h after the ingestion of V. rubricaulis. Clinical courses lasted 6-56 h after the ingestion of the plant. Serum activities of aspartate aminotransferase, gamma-glutamyl transferase, and alkaline phosphatase were highly elevated and glucose blood levels were low in affected sheep...
November 8, 2017: Toxicon: Official Journal of the International Society on Toxinology
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