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Claudia Kästner, Linda Böhmert, Albert Braeuning, Alfonso Lampen, Andreas F Thünemann
Silver nanoparticles are among the most widely used und produced nanoparticles. Due to their frequent application in consumer products, the assessment of their toxicological potential has seen a renewed importance. A major difficulty is the traceability of nanoparticles in in vitro and in vivo experiments. Even if the particles are labeled, for example by a fluorescent marker, the dynamic exchange of ligands often prohibits their spatial localization. Our study provides an insight into the adsorption and desorption kinetics of two different fluorescent labels on silver nanoparticles with a core radius of 3 nm by dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and fluorescence spectroscopy...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Andrei Kolesnikov, Nikolaj Georgi, Yury A Budkov, Jens Möllmer, Jorg Hofmann, Juergen Adolphs, Roger Gläser
We present a new model of adsorption-induced deformation of mesoporous solids. The model is based on a simplified version of Local Density Functional Theory in the framework of solvation free energy. Instead of density, which is treated as constant here, we used the film thickness and pore radius as order parameters. This allows us to obtain a self-consistent system of equations describing simultaneously the processes of gas adsorption and adsorbent deformation, as well as conditions for capillary condensation and evaporation...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Xu Zhu, Xinlin Li, Ti Zhang, Limei Zhao
The present study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy. A total of 210 epileptic patients, treated with VPA as monotherapy, were enrolled and classified into hyperammonaemia and control groups according to their blood ammonia level (cut-off value 50 μmol/L). Serum concentrations of VPA and its major metabolites were simultaneously determined by ultra-high performance liquid chromatography-tandem mass spectrometry...
May 23, 2018: Basic & Clinical Pharmacology & Toxicology
Anita Dawes, Natalia Pascual, Nigel J Mason, Sabrina Gärtner, Søren V Hoffmann, Nykola C Jones
We present results of a combined vacuum ultraviolet (VUV) and infrared (IR) photoabsorption study of amorphous benzene : water mixtures and layers to investigate the benzene-water interaction in the solid phase. VUV spectra of 1 : 1, 1 : 10 and 1 : 100 benzene : water mixtures at 24 K reveal a concentration dependent shift in the energies of the 1B2u, 1B1u and 1E1u electronic states of benzene. All the electronic bands blueshift from pure amorphous benzene towards gas phase energies with increasing water concentration...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
Shanxia Jin, Liping Liu, Ping Zhou
Amorphous titania was modified with boric acid, and the resulting material was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction and X-ray photoelectron spectrometry. The new material, in contrast to conventional boronate affinity materials containing boronic acid ligands, bears boric acid groups. It is shown to exhibit high specificity for glycoproteins, and this was applied to design a method for solid phase extraction of glycoproteins as shown for ribonuclease B, horse radish peroxidase and ovalbumin...
May 22, 2018: Mikrochimica Acta
Li-Qing Yu, Li-Ya Wang, Fei-Hong Su, Ping-Yu Hao, Huan Wang, Yun-Kai Lv
A stainless steel fiber was coated with a gate-opening controlled metal-organic framework ZIF-7 via a sol-gel method and applied to the solid-phase microextraction of aldehydes (hexanal, heptanal, octanal, nonanal, decanal) from exhaled breath by lung cancer patients. The effects of temperature and time on the sorption and desorption were optimized. Under optimum condition, the modified fiber displays enrichment factors (typically ranging from 300 to 10,000), low limits of detection (0.61-0.84 μg L-1 ), and wide linear ranges of hexanal, heptanal (5-500 μg L-1 ) and octanal, nonanal, decanal (10-1000 μg L-1 )...
May 22, 2018: Mikrochimica Acta
Dezhong Yang, Shaoze Zhang, De-En Jiang, Sheng Dai
Deep eutectic solvents (DESs) based on 1-ethyl-3-methylimidazolium chloride (EmimCl) and triethylene glycol (TEG) with different molar ratios (from 6 : 1 to 1 : 1) were prepared. FTIR and theoretical calculation indicated that the C2-H on the imidazolium ring form hydrogen bonds with the hydroxyl group rather than the ether O atom of the TEG. The EmimCl-TEG DESs can efficiently capture SO2; in particular, EmimCl-TEG (6 : 1) can capture 0.54 g SO2 per gram of solvent at 0.10 atm and 20 °C, the highest absorption amount for DESs under the same conditions...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
Jing-Wei Cheng, Chang Liu, Timothy Kudinha, Meng Xiao, Shu-Ying Yu, Chun-Xia Yang, Ming Wei, Guo-Wei Liang, Dong-Hua Shao, Fanrong Kong, Zhao-Hui Tong, Ying-Chun Xu
Clostridium difficile is the leading cause of health care-associated infections. Previous studies suggest that C. difficile MLST clade 4 strains with higher drug resistance rates constitute the major clone spreading in China. Thus development of a rapid and accurate typing method for these strains is needed to monitor the epidemiology of this clone and to guide clinical treatment. A total of 160 non-duplicate C. difficile isolates recovered from three large teaching hospitals in Beijing were studied. All the 41 clade 4 C...
April 26, 2018: Diagnostic Microbiology and Infectious Disease
Mateusz Janeta, Wojciech Bury, Slawomir Szafert
The efficient capture and storage of radioactive iodine (129 I or 131 I), which can be formed during nuclear energy generation or storage of nuclear waste, is of paramount importance. Herein we present highly efficient aerogels for reversible iodine capture, namely Porous Silsesquioxane-Imine Frameworks (PSIF), constructed by a condensation of octa(3-aminopropyl)silsesquioxane cage compound (OAS-POSS) and selected multitopic aldehydes. The resulting PSIFs are permanently porous (Brunauer-Emmet-Teller (BET) surface areas up to 574 m2 /g), thermally stable and present a combination of micro-, meso- and macropores in their structures...
May 23, 2018: ACS Applied Materials & Interfaces
Guillaume Colas, Aurélien Saulot, David Philippon, Yves Berthier, Didier Leonard
Controlling and predicting the tribological behavior of dry lubricant is a necessity to ensure low friction, long life, and low particle generation. Understanding the tribochemistry of the materials as a function of the environment is of primary interest as synergistic effects exist between the mechanics, the physicochemistry, the thermodynamics within a contact. However, in most studies the role of the coating internal contaminants in the process is often discarded to the benefit of a more common approach in which the performances of the materials are compared as a function of different atmospheric pressure environments...
May 23, 2018: ACS Applied Materials & Interfaces
Salman Ul Islam, Muhammad Bilal Ahmed, Su Jin Lee, Adeeb Shehzad, Jong Kyung Sonn, Oh-Shin Kwon, Young Sup Lee
Cell actin cytoskeleton is primarily modulated by Rho family proteins. RhoA regulates several downstream targets, including Rho-associated protein kinase (ROCK), LIM-Kinase (LIMK), and cofilin. Pre-mRNA processing factor 4B (PRP4) modulates the actin cytoskeleton of cancer cells via RhoA activity inhibition. In this study, we discovered that PRP4 over-expression in HCT116 colon cancer cells induces cofilin dephosphorylation by inhibiting the Rho-ROCK-LIMK-cofilin pathway. Two-dimensional gel electrophoresis, and matrix-assisted laser desorption/ionization time-of-flight mass-spectrometry (MALDI-TOF MS) analysis indicated increased expression of protein phosphatase 1A (PP1A) in PRP4-transfected HCT116 cells...
May 19, 2018: Experimental Cell Research
Yu-Ting Tseng, Hsiang-Yu Chang, Scott G Harroun, Chien-Wei Wu, Shih-Chun Wei, Zhiqin Yuan, Hung-Lung Chou, Ching-Hsiang Chen, Chih-Ching Huang, Huan-Tsung Chang
Stereospecific recognition of chiral molecules is ubiquitous in chemical and biological systems, thus leading to a strong de-mand for the development of enantiomeric drugs, enantioselective sensors, and asymmetric catalysts. In this study, we demonstrate the ratio of D-Cys and L-Cys playing an important role in determining the optical properties and the structures of self-assembled Cys-Au(I) supramolecules prepared through a simple reaction of tetrachloroaurate(III) with chiral cyste-ine (Cys). The irregularly shaped -[D-Cys-Au(I)] n - or -[L-Cys-Au(I)] n - supramolecules with a size larger than 500 nm pos-sessing strong absorption in the near-UV region and chiroptical characteristics were only obtained from the reaction of Au(III) with D-Cys or L-Cys...
May 22, 2018: Analytical Chemistry
Michael Woolman, Arash Zarrine-Afsar
Ambient Mass Spectrometry (MS) analysis is widely used to characterize biological and non-biological samples. Advancements that allow rapid analysis of samples by ambient methods such as Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) and Rapid Evaporative Ionization Mass Spectrometry (REIMS) are discussed. A short, non-comprehensive overview of ambient MS is provided that only contains example applications due to space limitations. A spatially encoded mass spectrometry analysis concept to plan cancer resection is introduced...
May 22, 2018: Analyst
Meng Zhang, Qingyu Zhai, Liping Wan, Li Chen, Yu Peng, Chunyan Deng, Juan Xiang, Jiawei Yan
Layer-by-layer dissolution and permeable pore formation are two typical membrane damage pathways, which induce membrane function disorder and result in serious disease, such as Alzheimer's disease, Keshan disease, Sickle-cell disease and so on. To effectively distinguish and sensitively monitor these two typical membrane damage pathways, a facile electrochemical impedance strategy was developed on a porous self-assembly monolayer (pSAM) supported bilayer lipid membrane (BLM). The pSAM was prepared by selectively electrochemical reductive desorption of the mercaptopropionic acid in a mixed mercaptopropionic acid/11-mercaptoundecanoic acid self-assembled monolayer, which created plenty of nanopores with tens of nanometers in diameter and several nanometers in height (defined as inner-pores)...
May 22, 2018: Analytical Chemistry
Lei Zang, Weiyi Sun, Song Liu, Yike Huang, Huatang Yuan, Zhanliang Tao, Yijing Wang
Lithium borohydride (LiBH4) is of particular interest as one of the most promising candidates for solid-state hydrogen storage. Herein, LiBH4 is confined into a novel 2D layered Ti3C2 MXene through one-step solvent method for the first time to improve its hydrogen storage properties. The initial desorption temperature of LiBH4 is significantly reduced, and the de-/hydrogenation kinetics are remarkably enhanced. It is found that the onset temperature of LiBH4@2Ti3C2 hybrid is reduced to172.6 °C and releases 9...
May 22, 2018: ACS Applied Materials & Interfaces
Bárbara Viero de Noronha, Márcio Fernando Bergamini, Luiz Humberto Marcolino Junior, Bruno José Gonçalves da Silva
In this study, a simple, efficient, and reusable device based on cellulose membranes modified with polypyrrole was developed to extract 14 emerging contaminants from aqueous matrices. For chemical polymerization, a low-cost cellulose membrane was immersed in 0.1 mol L-1 pyrrole and 0.5 mol L-1 ammonium persulfate for 40 min in an ice/water bath. The cellulose membranes modified with polypyrrole were accommodated in a polycarbonate holder suitable for solid-phase extraction disks. Solid-phase extraction parameters that affect extraction efficiency, such as sample volume, pH, flow-rate, and desorption were optimized...
May 21, 2018: Journal of Separation Science
Mohamad Sukri Mohamad Yusof, Mohd Hafiz Dzarfan Othman, Azeman Mustafa, Mukhlis Abdul Rahman, Juhana Jaafar, Ahmad Fauzi Ismail
Palm oil fuel ash (POFA) is an agricultural waste which was employed in this study to produce novel adsorptive ceramic hollow fibre membranes. The membranes were fabricated using phase inversion-based extrusion technique and sintered at 1150 °C. The membranes were then evaluated on their ability to adsorb cadmium (Cd(II)). These membranes were characterised using (nitrogen) N2 adsorption-desorption analysis, field emission scanning electron microscopy-energy-dispersive X-ray spectroscopy (FESEM-EDX) mapping, X-ray fluorescence (XRF), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) analyses while adsorptivity activity was examined by batch adsorption studies...
May 21, 2018: Environmental Science and Pollution Research International
Beijiao Cui, Bin Guo, Huimin Wang, Doudou Zhang, Haiyan Liu, Ligai Bai, Hongyuan Yan, Dandan Han
A composite monolithic column was prepared by redox initiation method for the on-line purification and enrichment of β-sitosterol, in which graphene oxide (GO) was embedded. The obtained monolithic column was characterized by scanning electron microscopy (SEM) and nitrogen adsorption-desorption isotherm measurement, which indicated that the monolith possessed characteristics of porous structure and high permeability. Under the optimum conditions for extraction and determination, the calibration equation was y = 47...
August 15, 2018: Talanta
Miao Chen, Ranhao Wang, Yuqiu Zhu, Minzhuo Liu, Fawei Zhu, Jianbo Xiao, Xiaoqing Chen
Herein, for the first time, thiol-functionalized mesoporous silica (mSiO2 -SH) nanofibers with a spirally-curved twisted hexagonal morphology were synthesized via a simple one-pot protocol. 4-Mercaptophenylboronic acids (4-MPBA) were attached onto the mSiO2 -SH nanofibers via disulfide bond, serving as boronate affinity sorbent to selectively capture brassinosteroids (BRs) from plant extract. The resulting BRs-MPBA derivatives were easily eluted from the sorbent by cleaving the disulfide bond, which was subsequently subjected to ultra performance liquid chromatography-mass spectrometry (UPLC-MS) analysis...
October 15, 2018: Food Chemistry
Jun Kobayashi, Yoshinori Arisaka, Nobuhiko Yui, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
Thermoresponsive cell-culture polystyrene (PS) surfaces that are grafted with poly( N -isopropylacrylamide) (PIPAAm) facilitate the cultivation of cells at 37 °C and the detachment of cultured cells as a sheet with an underlying extracellular matrix (ECM) by reducing the temperature. However, the ECM and cell detachment mechanisms are still unclear because the detachment of cells from thermoresponsive surfaces is governed by complex interactions among the cells/ECM/surface. To explore the dynamic behavior of serum protein adsorption/desorption, thermoresponsive surfaces that correspond to thermoresponsive tissue-culture PS dishes were formed on sensor chips for quartz crystal microbalance with dissipation (QCM-D) measurements...
May 18, 2018: International Journal of Molecular Sciences
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