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https://www.readbyqxmd.com/read/28338408/clofazimine-encapsulation-in-nanoporous-silica-particles-for-the-oral-treatment-of-antibiotic-resistant-mycobacterium-tuberculosis-infections
#1
Sabrina Valetti, Xin Xia, Joana Costa-Gouveia, Priscille Brodin, Marie-Françoise Bernet-Camard, Margareta Andersson, Adam Feiler
AIM: First extensive reformulation of clofazimine (CLZ) in nanoporous silica particles (NSPs) for tackling antibiotic-resistant tuberculosis (TB) infections. MATERIALS & METHODS: Solid-state characterization of several CLZ-encapsulated NSP formulations was followed by in vitro drug solubility, Caco-2 intestinal cells drug permeability and TB antibacterial activity. RESULTS: NSPs stabilize the amorphous state of CLZ (shelf stability >6 months) and dramatically increase the drug solubility in simulated gastric fluid (up to 20-fold) with different dissolution kinetics depending on the NSPs used...
March 24, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28338003/directional-phonon-suppression-function-as-a-tool-for-the-identification-of-ultralow-thermal-conductivity-materials
#2
Giuseppe Romano, Alexie M Kolpak
Boundary-engineering in nanostructures has the potential to dramatically impact the development of materials for high- efficiency conversion of thermal energy directly into electricity. In particular, nanostructuring of semiconductors can lead to strong suppression of heat transport with little degradation of electrical conductivity. Although this combination of material properties is promising for thermoelectric materials, it remains largely unexplored. In this work, we introduce a novel concept, the directional phonon suppression function, to unravel boundary-dominated heat transport in unprecedented detail...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337073/real-time-dna-sequencing-in-the-antarctic-dry-valleys-using-the-oxford-nanopore-sequencer
#3
Sarah S Johnson, Elena Zaikova, David S Goerlitz, Yu Bai, Scott W Tighe
The ability to sequence DNA outside of the laboratory setting has enabled novel research questions to be addressed in the field in diverse areas, ranging from environmental microbiology to viral epidemics. Here, we demonstrate the application of offline DNA sequencing of environmental samples using a hand-held nanopore sequencer in a remote field location: the McMurdo Dry Valleys, Antarctica. Sequencing was performed using a MK1B MinION sequencer from Oxford Nanopore Technologies (ONT; Oxford, United Kingdom) that was equipped with software to operate without internet connectivity...
March 22, 2017: Journal of Biomolecular Techniques: JBT
https://www.readbyqxmd.com/read/28336897/three-dimensional-bioi-biox-x-cl-or-br-nanohybrids-for-enhanced-visible-light-photocatalytic-activity
#4
Yazi Liu, Jian Xu, Liqiong Wang, Huayang Zhang, Ping Xu, Xiaoguang Duan, Hongqi Sun, Shaobin Wang
Three-dimensional flower-like BiOI/BiOX (X = Br or Cl) hybrids were synthesized via a facile one-pot solvothermal approach. With systematic characterizations by X-ray diffraction (XRD), scanning electron microscopy (SEM), Transmission electron microscopy (TEM), the Brunauer-Emmett-Teller (BET)specific surface area, X-ray photoelectron spectroscopy (XPS), and the UV-Vis diffuse reflectance spectra (DRS), the BiOI/BiOCl composites showed a fluffy and porous 3-D architecture with a large specific surface area (SSA) and high capability for light absorption...
March 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28335603/molecular-dynamics-simulation-of-water-transport-mechanisms-through-nanoporous-boron-nitride-and-graphene-multilayers
#5
Majid Shahbabaei, Daejoong Kim
In this study, molecular dynamics simulations are used to investigate water transport mechanisms through hourglass-shaped pore structure in nanoporous boron nitride (BN) and graphene multilayers. An increase in water flux is evidenced as the gap between the layers increases, reaching a maximum of 41 and 43 at d=6 Å in BN and graphene multilayers, respectively. Moreover, the BN multilayer exhibits less flux compared to graphene due to large friction force and energy barrier. In BN, the friction force dramatically increases when the layers are strongly stacked (d=3...
March 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28335341/design-and-electrochemical-study-of-platinum-based-nanomaterials-for-sensitive-detection-of-nitric-oxide-in-biomedical-applications
#6
REVIEW
Maduraiveeran Govindhan, Zhonggang Liu, Aicheng Chen
The extensive physiological and regulatory roles of nitric oxide (NO) have spurred the development of NO sensors, which are of critical importance in neuroscience and various medical applications. The development of electrochemical NO sensors is of significant importance, and has garnered a tremendous amount of attention due to their high sensitivity and selectivity, rapid response, low cost, miniaturization, and the possibility of real-time monitoring. Nanostructured platinum (Pt)-based materials have attracted considerable interest regarding their use in the design of electrochemical sensors for the detection of NO, due to their unique properties and the potential for new and innovative applications...
November 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335237/dna-sequencing-by-hexagonal-boron-nitride-nanopore-a-computational-study
#7
Liuyang Zhang, Xianqiao Wang
The single molecule detection associated with DNA sequencing has motivated intensive efforts to identify single DNA bases. However, little research has been reported utilizing single-layer hexagonal boron nitride (hBN) for DNA sequencing. Here we employ molecular dynamics simulations to explore pathways for single-strand DNA (ssDNA) sequencing by nanopore on the hBN sheet. We first investigate the adhesive strength between nucleobases and the hBN sheet, which provides the foundation for the hBN-base interaction and nanopore sequencing mechanism...
June 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334395/pore-guis-for-parallel-and-real-time-processing-of-minion-sequence-data
#8
Robert Stewart, Mick Watson
Motivation: Oxford Nanopore's MinION device has matured rapidly and is now capable of producing over one million reads and several gigabases of sequence data per run. The nature of the MinION output requires new tools that are easy to use by scientists with a range of computational skills and which enable quick and simple QC and data extraction from MinION runs. Results: We have developed two GUIs for the R package poRe that allow parallel and real-time processing of MinION datasets...
March 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334071/on-the-design-and-prospects-of-direct-rna-sequencing
#9
Georgi K Marinov
Throughout the past nearly a decade, the application of high-throughput sequencing to RNA molecules in the form of RNA sequencing (RNA-seq) and its many variations has revolutionized transcriptomic studies by enabling researchers to take a simultaneously deep and truly global look into the transcriptome. However, there is still considerable scope for improvement on RNA-seq data in its current form, primarily because of the short-read nature of the dominant sequencing technologies, which prevents the completely reliable reconstruction and quantification of full-length transcripts, and the sequencing library building protocols used, which introduce various distortions in the final data sets...
February 17, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28333410/pd-metalated-conjugated-nanoporous-polycarbazoles-for-additive-free-cyanation-of-aryl-halides-boosting-catalytic-efficiency-via-spatial-modulation
#10
Shunmin Ding, Chengcheng Tian, Xiang Zhu, Carter W Abney, Ziqi Tian, Bo Chen, Meijun Li, De-En Jiang, Ning Zhang, Sheng Dai
A novel spatial-modulation approach was developed to fabricate a new heterogeneous Pd-metalated nanoporous polymer for efficient and ligand-free cyanation of aryl halides. The resulting catalyst displays high activity in the synthesis of benzonitriles, including high product yield, excellent stability and recycle, and broad scope functional group tolerance.
March 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28332664/kinetics-of-ozone-decomposition-in-porous-in2o3-monoliths
#11
Danielle Klawinski, Christian Weinberger, Dominik Klaus, Jan-Henrik Smått, Michael Tiemann, Thorsten Wagner
The performance of many chemical gas-phase reactions is strongly influenced by the interaction of reactants with interfaces. Nanoporous materials, which exhibit pore diameters up to 100 nm and high specific surface areas, can be utilized to reduce the amount of cost-intensive materials (e.g. noble metals). However, due to limitations in material transport and reaction kinetics detailed knowledge of the diffusion and the kinetics of a chemical reaction is necessary to improve the performance of chemical processes in industry and research...
March 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28332478/addressed-immobilization-of-biofunctionalized-diatoms-on-electrodes-by-gold-electrodeposition
#12
S Leonardo, D Garibo, M Fernández-Tejedor, C K O'Sullivan, M Campàs
Diatoms are single cell microalgae with a silica shell (frustule), which possess a micro/nanoporous pattern of unparalleled diversity far beyond the possibilities of current micro- and nanofabrication techniques. To explore diatoms as natural three-dimensional nanostructured supports in sensing and biosensing devices, a simple, rapid and stable method to immobilize diatoms via gold electrodeposition is described. In this process, gold microstructures are formed, immobilizing diatoms by entrapment or crossing their nanopores...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28327976/minion%C3%A2-nanopore-sequencing-of-environmental-metagenomes-a-synthetic-approach
#13
Bonnie L Brown, Mick Watson, Samuel S Minot, Maria C Rivera, Rima B Franklin
Background: Environmental metagenomic analysis is typically accomplished by assigning taxonomy and/or function from whole genome sequencing (WGS) or 16S amplicon sequences. Both of these approaches are limited, however, by read length, among other technical and biological factors. A nanopore-based sequencing platform, MinION™, produces reads that are ≥1×10 4 bp in length, potentially providing for more precise assignment, thereby alleviating some of the limitations inherent in determining metagenome composition from short reads...
February 24, 2017: GigaScience
https://www.readbyqxmd.com/read/28327957/nanosim-nanopore-sequence-read-simulator-based-on-statistical-characterization
#14
Chen Yang, Justin Chu, René L Warren, Inanç Birol
Background: The MinION sequencing instrument from Oxford Nanopore Technologies (ONT) produces long read lengths from single-molecule sequencing - valuable features for detailed genome characterization. To realize the potential of this platform, a number of groups are developing bioinformatics tools tuned for the unique characteristics of its data. We note that these development efforts would benefit from a simulator software, output of which could be used to benchmark analysis tools. Findings: Here, we introduce NanoSim, a fast and scalable read simulator that captures the technology-specific features of ONT data, and allows for adjustments upon improvement of nanopore sequencing technology...
February 24, 2017: GigaScience
https://www.readbyqxmd.com/read/28327913/the-use-of-oxford-nanopore-native-barcoding-for-complete-genome-assembly
#15
Sion C Bayliss, Vicky L Hunt, Maho Yokoyama, Harry A Thorpe, Edward J Feil
Background: The Oxford Nanopore Technologies MinION(TM) is a mobile DNA sequencer that can produce long read sequences with a short turn-around time. Here we report the first demonstration of single contig genome assembly using Oxford Nanopore native barcoding when applied to a multiplexed library of 12 samples and combined with existing Illumina short-read data. This paves the way for the closure of multiple bacterial genomes from a single MinION(TM) sequencing run, given the availability of existing short-read data...
February 24, 2017: GigaScience
https://www.readbyqxmd.com/read/28326666/from-millimeter-to-subnanometer-vapor-solid-deposition-of-carbon-nitride-hierarchical-nanostructures-directed-by-supramolecular-assembly
#16
Jingsan Xu, Hong Wang, Chao Zhang, Xiaofei Yang, Shaowen Cao, Jiaguo Yu, Menny Shalom
Shape and nanostructure control has great potential to enable graphitic carbon nitride (C3 N4 ) structures with new properties and functionalities. In this work, a new type of hierarchically structured nanoporous C3 N4 is introduced. The C3 N4 exhibits unique, edelweiss-like morphology, with components ranging from millimeter-sized bunches to subnanometer-thick layers. A one-step vapor-solid deposition approach using supramolecular aggregates as the precursor is carried out to accomplish the growth. Supramolecular pre-association plays a crucial role in achieving this nanostructure by directing the vaporization and deposition processes...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28325049/antibody-subclass-detection-using-graphene-nanopore
#17
Amir Barati Farimani, Mohammad Heiranian, Kyoungmin Min, Narayana R Aluru
Solid-state nanopores are promising for label free protein detection. The large thickness, ranging from several tens of nanometers to micrometers and larger, of solid-state nanopores prohibits atomic scale scanning or interrogation of proteins. Here, a single-atom thick graphene nanopore is shown to be highly capable of sensing and discriminating between different subclasses of IgG antibodies despite their minor and subtle variation in atomic structure. Extensive molecular dynamics (MD) simulations, rigorous statistical analysis with a total aggregate simulation time of 2...
March 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28321678/analysis-of-formaldehyde-and-acrolein-in-the-aqueous-samples-using-a-novel-needle-trap-device-containing-nanoporous-silica-aerogel-sorbent
#18
Abdullah Barkhordari, Mansour R Azari, Rezvan Zendehdel, Mahmoud Heidari
In this research, a needle trap device (NTD) packed with nanoporous silica aerogel as a sorbent was used as a new technique for sampling and analysis of formaldehyde and acrolein compounds in aqueous and urine samples. The obtained results were compared with those of the commercial sorbent Carboxen1000. Active sampling was used and a 21-G needle was applied for extraction of gas in the sample headspace. The optimization of experimental parameters like salt addition, temperature and desorption time was done and the performance of the NTD for the extraction of the compounds was evaluated...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28319036/n-doped-nanoporous-co3o4-nanosheets-with-oxygen-vacancies-as-oxygen-evolving-electrocatalysts
#19
Lei Xu, Zhimin Wang, Jialu Wang, Zhaohui Xiao, Xiaobing Huang, Zhigang Liu, Shuangyin Wang
Developing highly active electrocatalysts for the oxygen evolution reaction (OER) with a high surface area, high catalytic activity, low cost and high conductivity is a big challenge for various energy technologies. Herein, for the first time, we realized the simultaneous nitrogen doping and etching of Co3O4 nanosheets to produce N-doped nanoporous Co3O4 nanosheets with oxygen vacancies by N2 plasma. The increase in active sites in N-doped Co3O4 nanosheets and improved electronic conductivity with N doping and oxygen vacancies results in excellent electrocatalytic activity for the OER...
March 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28318494/the-role-of-the-irreversible-electroporation-in-the-hepato-pancreatico-biliary-surgery
#20
Patricia Sánchez-Velázquez, Pierre-Alain Clavien
Irreversible electroporation is a novel technique growing in popularity over the last years among the ablative modalities. Its unique action mechanism produces irreversible nanopores in the membrane of the cell leading to apoptosis; therefore irreversible electroporation can be used to ablate substantial volumes of tissue without the undesirable thermal effects as the "heat sink effect". Moreover the extracellular matrix is left unperturbed, thus sparing the structural architecture of surrounding structures such as bile ducts and blood vessels...
March 16, 2017: Cirugía Española
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