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https://www.readbyqxmd.com/read/29786169/bangladeshi-children-with-acute-diarrhea-show-fecal-microbiomes-with-increased-streptococcus-abundance-irrespective-of-diarrhea-etiology
#1
Silas Kieser, Shafiqul A Sarker, Olga Sakwinska, Francis Foata, Shamima Sultana, Zeenat Khan, Shoheb Islam, Nadine Porta, Séverine Combremont, Bertrand Betrisey, Coralie Fournier, Aline Charpagne, Patrick Descombes, Annick Mercenier, Bernard Berger, Harald Brüssow
We report streptococcal dysbiosis in acute diarrhea irrespective of etiology. Compared to 20 healthy local controls, 71 Bangladeshi children hospitalized with acute diarrhea (AD) of viral, mixed viral/bacterial, bacterial and unknown etiology showed a significantly decreased bacterial diversity with loss of pathways characteristic for the healthy distal colon microbiome (mannan degradation, methylerythritol phosphate and thiamin biosynthesis), an increased proportion of fecal streptococci belonging to the Streptococcus bovis and Streptococcus salivarius species complexes, and an increased level of E...
May 22, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29778679/efficient-metal-adsorption-and-microbial-reduction-from-rawal-lake-wastewater-using-metal-nanoparticle-coated-cotton
#2
Attarad Ali, Ayesha Gul, Abdul Mannan, Muhammad Zia
This study was designed to investigate removal of toxic metals and reduction of bacterial count from Rawal Lake wastewater with novel nanocomposite sorbents. Iron, zinc and silver oxide nanoparticles (NPs) were attached on cotton. The nanocomposites (iron NPs on cotton (FeCt), zinc NPs on cotton (ZnCt) and silver NPs on cotton (AgCt)) were characterized by FTIR, XRD and SEM, which showed successful adsorption of 10-30 nm size nanoparticles. Batch experiments were performed to determine the adsorption capacity of nanocomposite for metal removal...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29774240/mannan-induced-nos2-in-macrophages-enhances-il-17-driven-psoriatic-arthritis-by-innate-lymphocytes
#3
Jianghong Zhong, Tatjana Scholz, Anthony C Y Yau, Simon Guerard, Ulrike Hüffmeier, Harald Burkhardt, Rikard Holmdahl
Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive oxygen species (ROS), we found that NO was detectable before disease onset in mice, independent of a functional nicotinamide adenine dinucleotide phosphate oxidase 2 complex. MIP was suppressed by either deletion of Nos2 or inhibition of NO synthases with NG-nitro-l-arginine methyl ester, demonstrating that Nos2-derived NO is pathogenic...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29772939/enabling-appropriate-personnel-skill-mix-for-progressive-realization-of-equitable-access-to-assistive-technology
#4
Emma M Smith, Rosemary Joan Gowran, Hasheem Mannan, Brian Donnelly, Liliana Alvarez, Diane Bell, Silvana Contepomi, Liezel Ennion Wegner, Evert-Jan Hoogerwerf, Tracey Howe, Yih-Kuen Jan, Jeanne Kagwiza, Natasha Layton, Ritchard Ledgerd, Malcolm MacLachlan, Giulia Oggero, Cecilia Pettersson, Thais Pousada, Elsje Scheffler, Sam Wu
BACKGROUND AND METHODS: This paper reviews the current capacity of personnel in enabling access to assistive technology (AT) as well as the systems and processes within which they work, and was reviewed, discussed, and refined during and following the Global Research, Innovation, and Education in Assistive Technology (GREAT) Summit. FINDINGS: Key concepts addressed include a person-centred team approach; sustainability indicators to monitor, measure, and respond to needs for service design and delivery; education, research, and training for competent practice, using the six rehab-workforce challenges framework; and credentialing frameworks...
May 17, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29769502/variation-of-luminal-diameter-of-the-right-principal-bronchus-in-different-age-and-sex-group-of-bangladeshi-cadaver
#5
N Nawshin, S Mannan, M F Kamal, E Z Epsi, Z Ahmed
The respiratory system is involved in the intake and exchange of oxygen and carbon dioxide between an organism and the environment which is essential for human survival. The bronchial tree includes the trachea, right and left principal bronchi and their branching upto alveoli. A common medical problem with the respiratory tract is acute respiratory tract infection (ARI) which is the leading killer of children under five. The aim of the present study was to find out the variation of the luminal diameter of right principal bronchus in Bangladeshi people...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769500/measurement-of-length-of-umbilical-cord-in-different-gestational-age-groups-in-bangladesh
#6
T Begum, M M Rahman, S Z Sultana, S A Ahmed, S Mannan, Z G Ara, A Ara, M M Hossain
The umbilical cord and placental have been considered to significantly contribute to the perinatal outcome. Long or short cord can lead to intrauterine fetal demise. So this type of study in placenta and umbilical cord can yield information for immediate and later management of newborn. This information may also be essential for protecting the attending physician in the event of a fetal outcome. This Cross sectional descriptive study would provide information about the length of umbilical cord in different gestational age groups in Bangladesh...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769497/correlation-of-triceps-skin-fold-thickness-with-weight-of-bangladeshi-garo-population
#7
S Farjan, M Khalil, S Mannan, S Chowdhury, A Kabir, S Ajmeri, N Naznin
This cross sectional, observational, descriptive and analytic type of study was designed to formulate a standard for Bangladeshi Garo population and an attempt has been made out to formulate a linear regression equation for estimation of weight from the triceps skin fold thickness in different areas of Mymensingh district (Mymensingh Sadar & Haluaghat Upazilla), Bangladesh from July 2015 to June 2016. The material consists of 104 Garo people (60 male, 44 female) between 20-40 years of age in Bangladesh...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769487/length-of-vermiform-appendix-in-bangladeshi-people-of-different-age-and-sex
#8
S A Sumi, M Khalil, S Mannan, S Chowdhury, M K Khan, U K Paul, U K Zaman, S F Karim, A Rahman, M M Rahman, A Kabir, S Farjan, M T Alam, E Z Epsi, N S Nitu, N J Khan, L Jabeen, S Tabriz
A cross sectional descriptive study was performed on 70 postmortem vermiform appendix (male 34 and female 36) to find out the length of vermiform appendix of Bangladeshi people in different age and sex. The specimens were collected from autopsy laboratory of the Department of Forensic Medicine, Mymensingh Medical College, Mymensingh, Bangladesh from October 2016 to March 2017 by purposive sampling technique. The collected samples were divided into four age groups. They were Group A (upto 20 years), Group B (21 to 40 years), Group C (41 to 60 years) and Group D (above 60 years)...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29757418/associations-of-arsenic-exposure-with-telomere-length-and-na%C3%A3-ve-t-cells-in-childhood-a-birth-cohort-study
#9
Tania Mannan, Sultan Ahmed, Evana Akhtar, Khalid Bin Ahsan, Ahsanul Haq, Maria Kippler, Marie Vahter, Rubhana Raqib
There is limited knowledge of association between arsenic exposure and telomere length (TL) and signal joint T-cell receptor excision circle (sjTREC) that are potential biomarkers of immune senescence and disease susceptibility. We aimed to clarify whether long-term inorganic arsenic exposure influences TL and sjTRECs in childhood. Children born in a longitudinal mother-child cohort were followed-up at 4.5 (n=275) and 9 years (n=351) of age. Arsenic exposure was assessed by metabolite concentrations in urine (U-As) from mothers at gestational week 8 (prenatal) and their children at 4...
May 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29757368/the-long-noncoding-rna-landscape-of-neuroendocrine-prostate-cancer-and-its-clinical-implications
#10
Varune Rohan Ramnarine, Mohammed Alshalalfa, Fan Mo, Noushin Nabavi, Nicholas Erho, Mandeep Takhar, Robert Shukin, Sonal Brahmbhatt, Alexander Gawronski, Maxim Kobelev, Mannan Nouri, Dong Lin, Harrison Tsai, Tamara L Lotan, R Jefferey Karnes, Mark A Rubin, Amina Zoubeidi, Martin E Gleave, Cenk Sahinalp, Alexander W Wyatt, Stanislav V Volik, Himisha Beltran, Elai Davicioni, Yuzhuo Wang, Colin C Collins
Background: Treatment induced neuroendocrine prostate cancer (tNEPC) is an aggressive variant of late-stage metastatic castrate resistant (mCRPC) prostate cancer that commonly arises through neuroendocrine transdifferentiation (NEtD). Treatment options are limited, ineffective, and for most patients, results in death in less than a year. We previously developed a first-in-field patient-derived xenograft (PDX) model of NEtD. Longitudinal deep transcriptome profiling of this model enabled monitoring of dynamic transcriptional changes during NEtD and in the context of androgen deprivation...
May 10, 2018: GigaScience
https://www.readbyqxmd.com/read/29753498/a-multimodal-intervention-to-improve-hand-hygiene-compliance-in-a-tertiary-care-center
#11
Abdul Mannan Laskar, Deepashree R, Prasanna Bhat, Biju Pottakkat, Sunil Narayan, Apurba Sankar Sastry, R Sneha
BACKGROUND: Healthcare-associated infections (HAIs) are a major threat to patient safety worldwide. HAIs are mainly transmitted via the hands of healthcare workers (HCWs), and HCW compliance with hand hygiene (HH) practices is reportedly low. Therefore, multimodal interventions are needed to develop effective HH improvement strategies. In this study, we assessed the effect of multimodal interventions on improvement of HH compliance. METHODS: This study was conducted in 2 intensive care units from August 2016 to October 2016...
May 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29740890/effect-of-adjuvants-on-in-ovo-vaccination-against-newcastle-disease-on-hatchability-performance-and-antibody-titres-in-commercial-pullets
#12
P Soleimani Roudi, A Golian, A Haghparast, M R Bassami, R Majidzadeh Heravi
This study was conducted to investigate the efficacy of in ovo administration of aluminium hydroxide (AH) and/or mannan oligosaccharide (MOS) adjuvants along with lentogenic VG/GA strain-Avinew to alleviate the embryonic pathogenicity of Newcastle disease virus. Six hundred and thirty fertilized Bovans eggs were divided into nine groups of 70 each incubated in a commercial hatchery and administered with eight types of in ovo injections in a factorial design of 2 × 2 × 2 including with/without AH, MOS and Newcastle disease vaccine (NDV), and one uninjected group on day 18 of incubation...
May 9, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29736690/osthole-ameliorates-neurogenic-and-inflammatory-hyperalgesia-by-modulation-of-inos-cox-2-and-inflammatory-cytokines-in-mice
#13
Gurjit Singh, Rajbir Bhatti, Rahul Mannan, Drishtant Singh, Anup Kesavan, Palwinder Singh
BACKGROUND: Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50 ), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are yet to be determined. METHODS: The animals (mice) were assessed for general behaviour and mortality in varying doses (50, 300, and 2000 mg kg-1 ) of osthole for acute toxicity over 14 days...
May 7, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29725647/progressive-iga-nephropathy-is-associated-with-low-circulating-mannan-binding-lectin-associated-serine-protease-3-masp-3-and-increased-glomerular-factor-h-related-protein-5-fhr5-deposition
#14
Nicholas R Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J Lomax-Browne, Annette G Hansen, Michelle Willicombe, Charles D Pusey, H Terence Cook, Steffen Thiel, Matthew C Pickering
Introduction: IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury. Methods: To elucidate the contribution of the lectin pathway to IgAN, we measured the 11 plasma lectin pathway components in a well-characterized cohort of patients with IgAN. Results: M-ficolin, L-ficolin, mannan-binding lectin (MBL)-associated serine protease (MASP)-1 and MBL-associated protein (MAp) 19 were increased, whereas plasma MASP-3 levels were decreased in patients with IgAN compared with healthy controls...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29723965/effective-saccharification-of-corn-stover-using-low-liquid-aqueous-ammonia-pretreatment-and-enzymatic-hydrolysis
#15
Nguyen Phuong Vi Truong, Tae Hyun Kim
Low-liquid aqueous ammonia (LLAA) pretreatment using aqueous ammonia was investigated to enhance enzymatic saccharification of corn stover. In this method, ground corn stover was simply contacted with aqueous ammonia mist (ammoniation step), followed by pretreatment at elevated temperature (90⁻150 °C) for an extended period (24⁻120 h) at different solid/liquid (S/L) ratios (0.29, 0.47 or 0.67), termed a pretreatment step. After that, excess (unreacted) ammonia was removed by evaporation, and the pretreated material was immediately saccharified by an enzyme without a washing step...
May 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29723205/dietary-yeast-derived-mannan-oligosaccharides-have-immune-modulatory-properties-but-do-not-improve-high-fat-diet-induced-obesity-and-glucose-intolerance
#16
Lisa R Hoving, Hendrik J P van der Zande, Amanda Pronk, Bruno Guigas, Ko Willems van Dijk, Vanessa van Harmelen
The indigestible mannan oligosaccharides (MOS) derived from the outer cell wall of yeast Saccharomyces cerevisiae have shown potential to reduce inflammation. Since inflammation is one of the underlying mechanisms involved in the development of obesity-associated metabolic dysfunctions, we aimed to determine the effect of dietary supplementation with MOS on inflammation and metabolic homeostasis in lean and diet-induced obese mice. Male C57BL/6 mice were fed either a low fat diet (LFD) or a high fat diet (HFD) with, respectively, 10% or 45% energy derived from lard fat, with or without 1% MOS for 17 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29722821/mannose-capped-lipoarabinomannan-in-mycobacterium-tuberculosis-pathogenesis
#17
Joanne Turner, Jordi B Torrelles
Mannose-capped lipoarabinomannan (ManLAM), present in all members of the Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high molecular mass amphipathic lipoglycan with a defined critical role in mycobacterial survival during infection. In particular, ManLAM is well-characterized for its importance in providing M. tuberculosis a safe portal of entry to phagocytes, regulating the intracellular trafficking network, as well as immune responses of infected host cells. These ManLAM immunological characteristics are thought to be linked to the subtle but unique and well-defined structural characteristics of this molecule, including but not limited to the degree of acylation, the length of the D-mannan and D-arabinan cores, the length of the mannose caps, as well as the presence of other acidic constituents such as succinates, lactates and/or malates, and also the presence of 5-methylthioxylosyl...
June 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29720523/conservation-of-mannan-synthesis-in-fungi-of-the-zygomycota-and-ascomycota-reveals-a-broad-diagnostic-target
#18
Amanda R Burnham-Marusich, Breeana Hubbard, Alexander J Kvam, Marcellene Gates-Hollingsworth, Heather R Green, Eric Soukup, Andrew H Limper, Thomas R Kozel
Ascomycetes and zygomycetes account for the majority of (i) fungi responsible for cutaneous, subcutaneous, and invasive human fungal infections, (ii) plant fungal pathogens, (iii) fungi that threaten global biodiversity, (iv) fungal agents of agricultural spoilage, and (v) fungi in water-damaged buildings. Rapid recognition of fungal infection (or contamination) enables early treatment (or remediation). A bioinformatics search found homologues of Saccharomyces cerevisiae Mnn9p present in members of the Zygomycota and Ascomycota phyla and absent in members of the Chytridiomycota and Basidiomycota...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29718196/role-of-protein-phosphomannosylation-in-the-candida-tropicalis-macrophage-interaction
#19
Marco J Hernández-Chávez, Bernardo Franco, Diana M Clavijo-Giraldo, Nahúm V Hernández, Eine Estrada-Mata, Héctor Manuel Mora-Montes
Candida tropicalis is an opportunistic fungal pathogen responsible for mucosal and systemic infections. The cell wall is the initial contact point between a fungal cell and the host immune system, and mannoproteins are important components that play key roles when interacting with host cells. In C. albicans, mannans are modified by mannosyl-phosphate moieties, named phosphomannans, which can work as molecular scaffolds to synthesize β1,2-mannooligosaccharides, and MNN4 is a positive regulator of the phosphomannosylation pathway...
April 27, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29713374/mannanase-hydrolysis-of-spruce-galactoglucomannan-focusing-on-the-influence-of-acetylation-on-enzymatic-mannan-degradation
#20
Jenny Arnling Bååth, Antonio Martínez-Abad, Jennie Berglund, Johan Larsbrink, Francisco Vilaplana, Lisbeth Olsson
Background: Galactoglucomannan (GGM) is the most abundant hemicellulose in softwood, and consists of a backbone of mannose and glucose units, decorated with galactose and acetyl moieties. GGM can be hydrolyzed into fermentable sugars, or used as a polymer in films, gels, and food additives. Endo -β-mannanases, which can be found in the glycoside hydrolase families 5 and 26, specifically cleave the mannan backbone of GGM into shorter oligosaccharides. Information on the activity and specificity of different mannanases on complex and acetylated substrates is still lacking...
2018: Biotechnology for Biofuels
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