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https://www.readbyqxmd.com/read/29149852/access-to-health-care-for-persons-with-disabilities-in-rural-south-africa
#1
R Vergunst, L Swartz, K-G Hem, A H Eide, H Mannan, M MacLachlan, G Mji, S H Braathen, M Schneider
BACKGROUND: Global research suggests that persons with disabilities face barriers when accessing health care services. Yet, information regarding the nature of these barriers, especially in low-income and middle-income countries is sparse. Rural contexts in these countries may present greater barriers than urban contexts, but little is known about access issues in such contexts. There is a paucity of research in South Africa looking at "triple vulnerability" - poverty, disability and rurality...
November 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29144972/building-bridges-through-science
#2
Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al'Absi, Fazal Arain, Juan Carlos Arango-Lasprilla, Deniz Atasoy, Jesus Avila, Ashraf Badawi, Hilmar Bading, Abdul Mannan Baig, Jimena Baleriola, Carlos Belmonte, Ilaria Bertocchi, Heinrich Betz, Colin Blakemore, Olaf Blanke, Philipp Boehm-Sturm, Tobias Bonhoeffer, Paolo Bonifazi, Nils Brose, Patrizia Campolongo, Tansu Celikel, Cathy C Chang, Ta-Yuan Chang, Ami Citri, Hollis T Cline, Jesus M Cortes, Kathleen Cullen, Kellie Dean, José M Delgado-Garcia, Mathieu Desroches, John F Disterhoft, John E Dowling, Andreas Draguhn, Sherif F El-Khamisy, Abdeljabbar El Manira, S Ather Enam, Juan M Encinas, Asier Erramuzpe, José A Esteban, Isabel Fariñas, Edmond Fischer, Izumi Fukunaga, Iñigo Gabilondo, Detlev Ganten, Albert Gidon, Juan Carlos Gomez-Esteban, Paul Greengard, Valery Grinevich, Agnés Gruart, Roger Guillemin, Ahmad R Hariri, Bassem Hassan, Michael Häusser, Yasunori Hayashi, Natasha K Hussain, Adnan Abdul Jabbar, Mohamed Jaber, Reinhardt Jahn, Essam Mohammed Janahi, Mohamed Kabbaj, Helmut Kettenmann, Merel Kindt, Shira Knafo, Georg Köhr, Shoji Komai, Harm Krugers, Bernd Kuhn, Nouria Lakhdar Ghazal, Matthew E Larkum, Mickey London, Beat Lutz, Carlos Matute, Luis Martinez-Millan, Mouna Maroun, James McGaugh, Ahmed A Moustafa, Anwar Nasim, Klaus-Armin Nave, Erwin Neher, Karoly Nikolich, Tiago Outeiro, Lucy M Palmer, Olga Penagarikano, Isabel Perez-Otano, Donald W Pfaff, Bruno Poucet, Atta-Ur Rahman, Pedro Ramos-Cabrer, Ali Rashidy-Pour, Richard J Roberts, Serafim Rodrigues, Joshua R Sanes, Andreas T Schaefer, Menahem Segal, Idan Segev, Saad Shafqat, Nikhat Ahmed Siddiqui, Hermona Soreq, Eduardo Soriano-García, Rainer Spanagel, Rolf Sprengel, Greg Stuart, Thomas C Südhof, Jan Tønnesen, Mario Treviño, Basim M Uthman, J Craig Venter, Alexei Verkhratsky, Craig Weiss, Torsten N Wiesel, Emre Yaksi, Ofer Yizhar, Larry J Young, Paul Young, Nasser H Zawia, José L Zugaza, Mazahir T Hasan
Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge" initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities.
November 15, 2017: Neuron
https://www.readbyqxmd.com/read/29144773/cancer-chemopreventive-antiproliferative-and-superoxide-anion-scavenging-properties-of-kluyveromyces-marxianus-and-saccharomyces-cerevisiae-var-boulardii-cell-wall-components
#3
Olivier Fortin, Blanca Aguilar-Uscanga, Khanh Dang Vu, Stephane Salmieri, Monique Lacroix
This study investigated the cancer chemopreventive, the antiradical, and the antiproliferative properties of polysaccharides extracts from cell wall of Saccharomyces boulardii and Kluyveromyces marxianus. β-glucan, mannan, and chitin were also quantified to identify the most important extract responsible for these biological properties. Soluble and insoluble glucans as well as mannoprotein were extracted from cell wall using single hot-alkaline method. Superoxide anion scavenging (antiradical capacity), NAD(P)H: quinone reductase (QR) (EC 1...
November 16, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29133101/antioxidant-antiproliferative-and-immunostimulatory-effects-of-cell-wall-%C3%AE-d-mannan-fractions-from-kluyveromyces-marxianus
#4
Éder Galinari, Jailma Almeida-Lima, Gorete Ribeiro Macedo, Hilário Cuquetto Mantovani, Hugo Alexandre Oliveira Rocha
This study evaluated the antioxidant, antiproliferative, and immunostimulatory properties of cell wall α-D-mannan fractions from yeast Kluyveromyces marxianus CCT7735. Filter centrifugation was used to obtain four fractions (KMM-1, KMM-2, KMM-3, and KMM-4) with molecular weight ranging from 7.6 to 75.1kDa. KMM-1 and KMM-2 comprised D-mannose with traces of D-glucose, whereas other fractions contained only D-mannose. Total sugar found in samples ranged from 85.9% to 96.1%, while protein and phenolic contents were 1...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29130796/allergen-immunotherapy
#5
Sonia Mannan
No abstract text is available yet for this article.
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29121851/outputs-and-growth-of-primary-care-databases-in-the-united-kingdom-bibliometric-analysis
#6
Zain Chaudhry, Fahmida Mannan, Angela Gibson-White, Usama Syed, Shirin Ahmed, Antonis Kousoulis, Azeem Majeed
BACKGROUND: Electronic health database (EHD) data is increasingly used by researchers. The major United Kingdom EHDs are the 'Clinical Practice Research Datalink' (CPRD), 'The Health Improvement Network' (THIN) and 'QResearch'. Over time, outputs from these databases have increased, but have not been evaluated. OBJECTIVE: This study compares research outputs from CPRD, THIN and QResearch assessing growth and publication outputs over a 10-year period (2004-2013)...
October 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29120173/elucidating-the-mechanisms-of-the-tomato-ovate-mutation-in-regulating-fruit-quality-using-proteomics-analysis
#7
Juhua Liu, Jing Zhang, Hongxia Miao, Caihong Jia, Jingyi Wang, Biyu Xu, Zhiqiang Jin
The ovate mutation has frequently been used to study changes in fruit shape but not fruit quality. A deterioration in fruit quality associated with the ovate mutation was discovered in this study. To elucidate how ovate influences the quality of fruit, we performed a proteomics analysis of the fruits of the ovate mutant (LA3543) and wild-type ("Ailsa Craig", LA2838A) using tandem mass tag analysis. The results indicated that the ovate mutation significantly influences fruit quality in a number of ways, including by reducing the expression of 1-aminocyclopropane-1-carboxylic acid oxidase 3 (ACO3) in ethylene biosynthesis, improving firmness by reducing the amount of pectinesterase and polygalacturonase, reducing sugar accumulation by downregulating the abundance of mannan endo-1,4-β-mannosidase 4, β-galactosidase, and β-amylase, and reducing the malic acid content by downregulating the accumulation of malic enzymes and malate synthase...
November 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29118762/lc3-associated-phagocytosis-is-required-for-dendritic-cell-inflammatory-cytokine-response-to-gut-commensal-yeast-saccharomyces-cerevisiae
#8
Dimitra Lamprinaki, Gemma Beasy, Aleksandra Zhekova, Alexandra Wittmann, Steve James, Jo Dicks, Yoichiro Iwakura, Shinobu Saijo, Xiaomin Wang, Chung-Wai Chow, Ian Roberts, Tamas Korcsmaros, Ulrike Mayer, Thomas Wileman, Norihito Kawasaki
The human fungal microbiota known as mycobiota is increasingly recognized as a critical factor in human gut health and disease. Non-pathogenic commensal yeasts such as Saccharomyces cerevisiae promote homeostasis in the gut, whereas dysbiosis of the gut mycobiota is associated with inflammation. Glycan-binding receptors (lectins) are key host factors in host-mycobiota interaction in the gut. They are expressed on immune cells such as dendritic cells (DCs) and recognize fungal polysaccharides. This interaction is imperative to mount appropriate immune responses for immune homeostasis in the gut as well as clearance of fungal pathogens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29108954/a-flexible-loop-for-mannan-recognition-and-activity-enhancement-in-a-bifunctional-glycoside-hydrolase-family-5
#9
Po-Huang Liang, Wen-Ling Lin, Han-Yu Hsieh, Tsung-Yi Lin, Chun-Hsu Chen, Sunil K Tewary, Hsiao-Lin Lee, Shuo-Fu Yuan, Barbara Yang, Jyun-Yu Yao, Meng-Chiao Ho
BACKGROUND: An array of glycoside hydrolases with multiple substrate specificities are required to digest plant cell wall polysaccharides. Cel5E from Clostridium thermocellum and Cel5A from Thermotoga maritima are two glycoside hydrolase family 5 (GH5) enzymes with high sequence and structural similarity, but notably possess different substrate specificities; the former is a bifunctional cellulase/xylanase and the latter is a cellulase/mannanase. A specific loop in TmCel5A, Tmloop, is one of the most structurally divergent regions compared to CtCel5E and interacts with substrates, suggesting the importance for mannan recognition...
November 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29107748/rheological-characteristics-and-chain-conformation-of-mannans-obtained-from-s-cerevisiae
#10
Hongzhi Liu, Yanan Li, Aimin Shi, Hu Hui, Xiaojing Sheng, Li Liu, Qiang Wang, Benu Adhikari
Mannans were extracted from S. cerevisiae, the rheological properties of mannan solutions were important in many industrial applications. In this paper, effects of mannans concentration, solution temperature, pH, type of salts and their concentrations on apparent viscosity were investigated. The conformational parameters of yeast mannas were determined by SEC-MALS-RI-DP. The Higiro's 1 and Higiro's 2 plots obtained by capillary viscometry gave an intrinsic viscosity of 0.166 and 0.131dl/g. The yeast mannan solution showed Newtonian flow behavior at all the tested concentrations...
October 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29078182/tungsten-vi-based-molecular-puzzle-photoluminescent-nanoparticles-easily-covered-with-biocompatible-natural-polysaccharides-via-direct-chelation
#11
Volodymyr Lobaz, Martin Hladik, Miloš Steinhart, Aleksandra Paruzel, Peter Černoch, Jiří Pánek, Miroslav Vetrík, Daniel Jirák, Markéta Jirátová, Ognen Pop-Georgievski, Miroslav Šlouf, Sébastien Garcia-Argote, Gregory Pieters, Eric Doris, Martin Hrubý
Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu(3+) or Tb(3+) nanoparticles (size range of 10-160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling...
October 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29077905/influence-of-different-yeast-cell-wall-preparations-and-their-components-on-performance-and-immune-and-metabolic-pathways-in-clostridium-perfringens-challenged-broiler-chicks
#12
Mohammed M Hashim, Ryan J Arsenault, James A Byrd, Michael H Kogut, Morouj Al-Ajeeli, Christopher A Bailey
A study was conducted to evaluate the influence of the purification of yeast cell wall (YCW) preparations on broiler performance and immunogenic and metabolic pathways under microbial challenge. A total of 240 (day old) chicks were distributed among two battery brooder units (48 pens; 5 birds/pen; 8 replicates/treatment). A basal starter diet was divided into 5 batches to create 6 dietary treatments; non-challenge (NCh-C) and challenge (Ch-C) controls, semi-purified YCW containing cytosol contents (SPYCW; 250 mg/kg), purified YCW (PYCW; 250 mg/kg), 50% purified beta-glucan (BG; 130 mg/kg), and 99...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29074203/a-simply-enzymatic-hydrolysis-pretreatment-for-%C3%AE-mannanase-production-from-konjac-powder
#13
Shengping You, Juanjuan Ding, Yemei Dai, Ruizhe Xing, Wei Qi, Mengfan Wang, Rongxin Su, Zhimin He
Currently, the traditional fermentation using konjac powder for β-mannanase production presents operational difficulties and high energy consumption, because of the individual hot air sterilization for konjac powder. A simply enzymatic hydrolysis pretreatment for konjac powder was developed to solve the problems of the traditional process in a 7-L fermenter. In the new process, when hydrolysis yield of konjac powder was above 50%, the media became liquid state from gelatinous state and could be sterilized immediately, avoiding the hot air sterilization and solving the operational difficulties...
September 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29074085/hypolipidemic-effect-of-mannans-from-c-albicans-serotypes-a-and-b-in-acute-hyperlipidemia-in-mice
#14
T A Korolenko, T P Johnston, E Machova, N P Bgatova, A P Lykov, N V Goncharova, Z Nescakova, A B Shintyapina, I V Maiborodin, O L Karmatskikh
Mannans, which are biological macromolecules of polysaccharide origin and function as immunomodulators, have been shown to stimulate macrophages in vivo by interaction with the mannose receptor. Thus, they can be used to stimulate macrophages in order to effectively remove circulating atherogenic lipoproteins. Our primary aim was to evaluate the hypolipidemic potential of mannans from C. albicans serotype A (mannan A) and serotype B (mannan B) in a murine model of hyperlipidemia. Mannan A and mannan B were shown to significantly (p<0...
October 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29073796/death-audit-in-the-neonatal-icu-of-a-tertiary-care-hospital-in-bangladesh-a-retrospective-chart-review
#15
Sanjoy Kumer Dey, Sharmin Afroze, Tariqul Islam, Ismat Jahan, Mohammad Kamrul Hassan Shabuj, Suraiya Begum, Mohammod Jobayer Chisti, Mohammad Abdul Mannan, Mohammod Shahidullah
BACKGROUND: Expectant reduction of neonatal mortality and formulation of preventive strategies can only be achieved by analysis of risk factors in a particular setting. This study aimed to document incidence of neonatal death and to analyze the risk factors associated with neonatal death. METHODS: This retrospective study was carried out in department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU) over a 12-month period from January to December 2015...
October 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29058403/traced-on-the-timeline-discovery-of-acetylcholine-and-the-components-of-the-human-cholinergic-system-in-a-primitive-unicellular-eukaryote-acanthamoeba-spp
#16
Abdul Mannan Baig, Zohaib Rana, Sumayya Tariq, Salima Lalani, H R Ahmad
Acetylcholine (ACh) is the neurotransmitter of cholinergic signal transduction that affects the target cells via muscarinic (mAChR) and nicotinic (nAChR) cholinergic receptors embedded in the cell membrane. Of the cholinergic receptors that bind to ACh, the mAChRs execute several cognitive and metabolic functions in the human central nervous system (CNS). Very little is known about the origins and autocrine/paracrine roles of the ACh in primitive life forms. With the recent report of the evidence of an ACh binding mAChR1 like receptor in Acanthamoeba spp...
November 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29053876/blood-hematological-and-biochemical-constituents-antioxidant-enzymes-immunity-and-lymphoid-organs-of-broiler-chicks-supplemented-with-propolis-bee-pollen-and-mannan-oligosaccharides-continuously-or-intermittently
#17
Y A Attia, H Al-Khalaifah, M S Ibrahim, A E Abd Al-Hamid, M A Al-Harthi, A El-Naggar
This study investigate the effect of bee pollen (BP) and/or propolis (Pro) as an alternative to Mannan oligosaccharides (Bio-MOS, a hydrolyzed yeast with natural and artificial flavors Alltech Inc) when given continuously or intermittently on antioxidant enzymes, immunity, weight and morphology of lymphoid organs of broilers. Thus, 324 unsexed one-day-old Arbor Acres broilers were randomly distributed into nine treatment groups, each replicated 6 times of 6 birds per replicate. The chicks were kept in wire cages and fed the same basal diet and were submitted to the following treatments: control without supplementation (control) or supplemented with BP at 300 mg, Pro at 300 mg, BP+Pro at 300 mg each and Bio-MOS at 0...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053819/changes-in-immune-and-metabolic-gut-response-in-broilers-fed-%C3%AE-mannanase-in-%C3%AE-mannan-containing-diets
#18
R J Arsenault, J T Lee, R Latham, B Carter, M H Kogut
β-galactomannans found in soy-based broiler feed are known to cause physiological effects that are hypothesized to be related to gut inflammation. Previous studies have shown that the incorporation of β-mannanase in the diet or as a supplement results in improvements to certain performance parameters related to gut health and feed conversion. Using kinome analysis, we characterized the mechanism of β-galactomannan activity and supplementation with β-mannanase on the gut of commercial broilers to understand the mode of action...
September 14, 2017: Poultry Science
https://www.readbyqxmd.com/read/29051097/production-of-low-molecular-weight-soluble-yeast-%C3%AE-glucan-by-an-acid-degradation-method
#19
Yuina Ishimoto, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Ken Kanzaki, Yoichiro Iwakura, Naohito Ohno
β-glucan is widely distributed in nature as water soluble and insoluble forms. Both forms of β-glucan are utilized in several fields, especially for functional foods. Yeast β-glucan is a medically important insoluble particle. Solubilization of yeast β-glucan may be valuable for improving functional foods and in medicinal industries. In the present study, we applied an acid degradation method to solubilize yeast β-glucan and found that β-glucan was effectively solubilized to low-molecular weight β-glucans by 45% sulfuric acid treatment at 20°C...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29030558/optical-conversion-of-pure-spin-currents-in-hybrid-molecular-devices
#20
May C Wheeler, Fatma Al Ma'Mari, Matthew Rogers, Francisco J Gonçalves, Timothy Moorsom, Arne Brataas, Robert Stamps, Mannan Ali, Gavin Burnell, B J Hickey, Oscar Cespedes
Carbon-based molecules offer unparalleled potential for THz and optical devices controlled by pure spin currents: a low-dissipation flow of electronic spins with no net charge displacement. However, the research so far has been focused on the electrical conversion of the spin imbalance, where molecular materials are used to mimic their crystalline counterparts. Here, we use spin currents to access the molecular dynamics and optical properties of a fullerene layer. The spin mixing conductance across Py/C60 interfaces is increased by 10% (5 × 10(18) m(-2)) under optical irradiation...
October 13, 2017: Nature Communications
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