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https://www.readbyqxmd.com/read/28624720/retention-of-perampanel-in-adults-with-pharmacoresistant-epilepsy-at-a-single-tertiary-care-center
#1
Tim Wehner, Shahidul Mannan, Sanchit Turaga, Kirtana Vallabhaneni, Hao Meng Yip, Carys Wiggans, Rohit Shankar, John S Duncan, Josemir W Sander
RATIONALE: Observational data on antiepileptic drugs (AEDs) inform about their use in clinical practice. We describe our clinical experience with perampanel (PER) in a large UK tertiary epilepsy center. METHODS: Adults initiated on PER between October 2012 and March 2015 were followed until they discontinued PER or 10 September 2016. Data on epilepsy syndrome, duration, seizure types, concomitant and previous AED use, PER dosing, efficacy and side effects were recorded...
June 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28624243/glutathione-production-from-mannan-based-bioresource-by-mannanase-mannosidase-expressing-saccharomyces-cerevisiae
#2
Alex Prima, Kiyotaka Y Hara, Apridah Cameliawati Djohan, Norimasa Kashiwagi, Prihardi Kahar, Jun Ishii, Hideki Nakayama, Fumiyoshi Okazaki, Bambang Prasetya, Akihiko Kondo, Yopi, Chiaki Ogino
This work aims to produce glutathione directly from mannan-based bioresources using engineered Saccharomyces cerevisiae. Mannan proved to be a valuable carbon source for glutathione production by this organism. Mannan-hydrolyzing S. cerevisiae was developed by heterologous expression of mannanase/mannosidase on its cell surface. This strain efficiently produced glutathione from mannose polysaccharide, β-1,4-mannan. Furthermore, it produced glutathione from locust bean gum (LBG), a highly dense and inexpensive mannan-based bioresource, as sole carbon source...
June 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28617874/candida-albicans-mannans-mediate-streptococcus-mutans-exoenzyme-gtfb-binding-to-modulate-cross-kingdom-biofilm-development-in-vivo
#3
Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J Krysan, Hyun Koo
Candida albicans is frequently detected with heavy infection by Streptococcus mutans in plaque-biofilms from children with early-childhood caries (ECC). This cross-kingdom biofilm contains an extensive matrix of extracellular α-glucans that is produced by an exoenzyme (GtfB) secreted by S. mutans. Here, we report that mannans located on the outer surface of C. albicans cell-wall mediates GtfB binding, enhancing glucan-matrix production and modulating bacterial-fungal association within biofilms formed in vivo...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28616796/comparison-of-surgeon-comfort-assessment-during-phacoemulsification-using-bilateral-topical-anesthesia-versus-ipsilateral-topical-anesthesia-a-randomized-controlled-study
#4
Rashim Mannan, Archna Pruthi, Sumeet Khanduja
AIM: To evaluate the effectiveness of bilateral use of topical anesthetic eye drops during phacoemulsification procedure as compared to use in one eye only. METHODS: This is a prospective double-blind randomized case study of 180 cases undergoing phacoemulsification under topical anesthesia using 0.5% proparacaine: Group 1 consisting of patients who had topical anesthetic eye drop instilled into the operating eye only and Group 2 consisting of patients who had both their eyes anesthetized using topical anesthetic eye drops...
June 14, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28602015/clinical-and-genetic-analysis-of-indian-patients-with-ndp-related-retinopathies
#5
Dhandayuthapani Sudha, Aparna Ganapathy, Puja Mohan, Ashraf U Mannan, Shuba Krishna, Srividya Neriyanuri, Meenakshi Swaminathan, Pukhraj Rishi, Subbulakshmi Chidambaram, Jayamuruga Pandian Arunachalam
PURPOSE: NDP-related retinopathies are a group of X-linked disorders characterized by degenerative and proliferative changes of the neuroretina, occasionally accompanied with varying degrees of mental retardation and sensorineural hearing loss. NDP is the predominant gene associated with NDP-related retinopathies. The purpose of this study was to report the clinical and genetic findings in three unrelated patients diagnosed with NDP-related retinopathies. METHODS: The patients underwent complete ophthalmic examination followed by genetic analyses...
June 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28601544/not-so-obvious-acute-herpes-esophagitis
#6
Yuji Yamada, Carlos Rodriguez, Abul Ala Syed Rifat Mannan, Matthew Harrington
No abstract text is available yet for this article.
June 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28588932/fasting-with-diabetes-a-prospective-observational-study
#7
Muhammad Jawad Noon, Haseeb Ahmad Khawaja, Osama Ishtiaq, Quratulain Khawaja, Sana Minhas, Asfandyar Khan Niazi, Abdul Mannan Khan Minhas, Umar Rasool Malhi
OBJECTIVES: To determine the proportion of diabetic patients who develop adverse glycaemic events when fasting regularly. DESIGN: Prospective observational study conducted at a tertiary care hospital in South Asia. Five hundred and twenty-three patients were assessed for eligibility, and 150 were included in the final analysis. Diabetic patients over 18 years of age who were willing to fast regularly and make a chart of their daily blood sugar levels were included in the study...
August 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28588644/directed-evolution-of-a-%C3%AE-mannanase-from-rhizomucor-miehei-to-improve-catalytic-activity-in-acidic-and-thermophilic-conditions
#8
Yan-Xiao Li, Ping Yi, Qiao-Juan Yan, Zhen Qin, Xue-Qiang Liu, Zheng-Qiang Jiang
BACKGROUND: β-Mannanase randomly cleaves the β-1,4-linked mannan backbone of hemicellulose, which plays the most important role in the enzymatic degradation of mannan. Although the industrial applications of β-mannanase have tremendously expanded in recent years, the wild-type β-mannanases are still defective for some industries. The glycoside hydrolase (GH) family 5 β-mannanase (RmMan5A) from Rhizomucor miehei shows many outstanding properties, such as high specific activity and hydrolysis property...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28588168/randomized-controlled-trial-of-slow-versus-rapid-enteral-feeding-advancements-on-the-clinical-outcomes-in-very-low-birth-weight-neonates
#9
F Ahmed, M A Mannan, A C Dey, N Nahar, Z Hasan, I Jahan, S K Dey, M Shahidullah
Starting and advancement of feeding in very low birth weight (VLBW) infants are big challenges for the neonatal practitioners. Wide variations in volume of feed advancement have observed in earlier trials both in slow and rapid advancement groups. Volume advancement in slow advancement groups have ranged from 10ml/kg/day to 23ml/kg/day and in rapid advancement groups have ranged from 15ml/kg/day to 45ml/kg/day in earlier different studies. This randomized controlled trial was conducted in neonatal intensive care unit (NICU) of Bangabandhu Sheikh Mujib Medical University (BSMMU) from April 2013 to July 2014 to evaluate the effects of slow versus rapid rates of feeding advancements on the clinical outcomes in very low birth weight infants...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28577916/complete-genome-sequence-of-bacillus-sp-275-producing-extracellular-cellulolytic-xylanolytic-and-ligninolytic-enzymes
#10
Gyeongtaek Gong, Seil Kim, Sun-Mi Lee, Han Min Woo, Tai Hyun Park, Youngsoon Um
Technologies for degradation of three major components of lignocellulose (e.g. cellulose, hemicellulose and lignin) are needed to efficiently utilize lignocellulose. Here, we report Bacillus sp. 275 isolated from a mudflat exhibiting various lignocellulolytic activities including cellulase, xylanase, laccase and peroxidase in the cell culture supernatant. The complete genome of Bacillus sp. 275 strain contains 3832 protein cording sequences and an average G+C content of 46.32% on one chromosome (4045,581bp) and one plasmid (6389bp)...
May 31, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28551246/structural-characterization-and-evaluation-of-prebiotic-activity-of-oil-palm-kernel-cake-mannanoligosaccharides
#11
Naveena Reddy Kalidas, Mookiah Saminathan, Intan Safinar Ismail, Faridah Abas, Prasenjit Maity, Syed Sirajul Islam, Nurhuda Manshoor, Khozirah Shaari
In this study, mannanoligosaccharides (MOS) were isolated from palm kernel cake by aqueous extraction using high temperature and pressure. Structural characterization of MOS was carried out using acid hydrolysis, methylation analysis, ESI-MS/MS and 1D/2D NMR. The prebiotic activity of MOS was evaluated in vitro using two probiotic Lactobacillus strains. Sugar analysis indicated the presence of mannose in each of the oligomers. Methylation and 1D/2D NMR analysis indicated that the MOS have a linear structure consisting of (1→4)-β-d-mannopyranosyl residues...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28543622/in-vivo-exfoliating-efficacy-of-biodegradable-beads-and-the-correlation-with-user-s-satisfaction
#12
J Kitsongsermthon, J Kreepoke, K Duangweang, A Tansirikongkol
BACKGROUND/PURPOSE: By the end of 2017, non-biodegradable microbeads will be prohibited in USA, UK and Europe, due to their environmental issue. There are biodegradable beads available, but their effect on skin desquamation has not been evaluated yet. This study aimed to understand the skin renewal time, moisturizing effect and user's satisfaction of gel scrubs containing different exfoliating beads. METHODS: Gel scrubs, containing polyethylene, mannan or wax beads, were used in this study...
May 24, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28535423/chromatographic-separation-and-detection-methods-of-aloe-arborescens-miller-constituents-a-systematic-review
#13
REVIEW
Jilan A Nazeam, Haidy A Gad, Hala M El-Hefnawy, Abdel-Naser B Singab
Aloe arborescens Miller (Family Asphodelaceae) is a member of genus Aloe, which is used in traditional medicine to cure various diseases. The extracts of the plant have been reported to possess anticancer, immunomodulator, antidiabetic, anti-inflammatory and antioxidant activities. The phytochemical investigations have revealed diverse chemical constituents, including phenolics [anthraquinones, anthrones, pyrones, chromones and coumarins], polysaccharides [arborans [(1-4) linked glucomannans, polysaccharide (A, B and C): (A: a linear (1-6)-O-α-glucan, B: a branching (1-2)-O-l-arabinose with (1-2)-O-d-galactose linkages and C: (1-4)-O-β-mannan with 18% acetyl group)]], glycoproteins and carboxypeptidase enzyme...
April 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28532122/mannan-endo-1-4-%C3%AE-mannosidase-from-kitasatospora-sp-isolated-in-indonesia-and-its-potential-for-production-of-mannooligosaccharides-from-mannan-polymers
#14
Nanik Rahmani, Norimasa Kashiwagi, JaeMin Lee, Satoko Niimi-Nakamura, Hana Matsumoto, Prihardi Kahar, Puspita Lisdiyanti, Yopi, Bambang Prasetya, Chiaki Ogino, Akihiko Kondo
Mannan endo-1,4-β-mannosidase (commonly known as β-mannanase) catalyzes a random cleavage of the β-D-1,4-mannopyranosyl linkage in mannan polymers. The enzyme has been utilized in biofuel production from lignocellulose biomass, as well as in production of mannooligosaccharides (MOS) for applications in feed and food industries. We aimed to obtain a β-mannanase, for such mannan polymer utilization, from actinomycetes strains isolated in Indonesia. Strains exhibiting high mannanase activity were screened, and one strain belonging to the genus Kitasatospora was selected...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28507160/emergent-magnetism-at-transition-metal-nanocarbon-interfaces
#15
Fatma Al Ma'Mari, Matthew Rogers, Shoug Alghamdi, Timothy Moorsom, Stephen Lee, Thomas Prokscha, Hubertus Luetkens, Manuel Valvidares, Gilberto Teobaldi, Machiel Flokstra, Rhea Stewart, Pierluigi Gargiani, Mannan Ali, Gavin Burnell, B J Hickey, Oscar Cespedes
Charge transfer at metallo-molecular interfaces may be used to design multifunctional hybrids with an emergent magnetization that may offer an eco-friendly and tunable alternative to conventional magnets and devices. Here, we investigate the origin of the magnetism arising at these interfaces by using different techniques to probe 3d and 5d metal films such as Sc, Mn, Cu, and Pt in contact with fullerenes and rf-sputtered carbon layers. These systems exhibit small anisotropy and coercivity together with a high Curie point...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28506204/antibiotic-effects-of-loperamide-homology-of-human-targets-of-loperamide-with-targets-in-acanthamoeba-spp
#16
Abdul Mannan Baig, Zohaib Rana, M Mohsin Mannan, S Sumayya Tariq, H R Ahmad
BACKGROUND: Loperamide is an anti-diarrheal drug prescribed for non-infectious diarrhea. The drug is an opioid receptor agonist, a blocker of voltage-dependent calcium channel (Cav) and a calmodulin (CaM) inhibitor on human cells. Loperamide has been reported to exert anti-amoebic effects against pathogenic strains of Acanthamoeba castellanii. OBJECTIVES: The precise mode of antibiotic action, cellular target homology with human counterparts and the pattern of cell death induced by loperamide in Acanthamoeba castellanii remain to be established...
April 25, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28505469/the-association-between-immune-markers-and-recent-suicide-attempts-in-patients-with-serious-mental-illness-a-pilot-study
#17
Faith Dickerson, Maria Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina Savage, Lucy Schweinfurth, Cassie Stallings, Kevin Sweeney, Armin Alaedini, Melanie Uhde, Emily Severance, Holly C Wilcox, Robert Yolken
Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP)...
May 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28493491/high-doses-of-recombinant-mannan-binding-lectin-inhibit-the-binding-of-influenza-a-h1n1-pdm09-virus-with-cells-expressing-dc-sign
#18
Lei Yu, Shiqiang Shang, Ran Tao, Caiyun Wang, Li Zhang, Hao Peng, Yinghu Chen
The pandemic influenza A (H1N1)pdm09 virus continues to be a threat to human health. Low doses of mannan-binding lectin (MBL) (<1 μg/mL) were shown not to protect against influenza A(H1N1)pdm09 infection. However, the effect of high doses of MBL has not been investigated. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) has been proposed as an alternative receptor for influenza A(H1N1)pdm09 virus. In this study, we examined the expression of DC-SIGN on DCs as well as on acute monocytic leukemia cell line, THP-1...
July 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28490083/combining-hydrothermal-pretreatment-with-enzymes-de-pectinates-and-exposes-the-innermost-xyloglucan-rich-hemicellulose-layers-of-wine-grape-pomace
#19
Anscha J J Zietsman, John P Moore, Jonatan U Fangel, William G T Willats, Melané A Vivier
Chardonnay grape pomace was treated with pressurized heat followed by enzymatic hydrolysis, with commercial or pure enzymes, in buffered conditions. The pomace was unfermented as commonly found for white winemaking wastes and treatments aimed to simulate biovalorization processing. Cell wall profiling techniques showed that the pretreatment led to depectination of the outer layers thereby exposing xylan polymers and increasing the extractability of arabinans, galactans, arabinogalactan proteins and mannans...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28479400/mannan-binding-lectin-associated-serine-protease-1-masp-1-mediates-immune-responses-against-aeromonas-hydrophila-in%C3%A2-vitro-and-in%C3%A2-vivo-in-grass-carp
#20
Yun-Fei Dang, Yu-Bang Shen, Xiao-Yan Xu, Shen-Tong Wang, Xin-Zhan Meng, Li-Sen Li, Meng Zhang, Mo-Yan Hu, Li-Qun Lv, Rong-Quan Wang, Jia-Le Li
The mannan-binding lectin-associated serine protease-1 (MASP-1) gene is a crucial component of the lectin pathway in the complement and coagulation cascade. Although MASP-1 has been found in the immune system of teleosts, its immune functions in response to bacterial infection are unclear. In this study, we identified a MASP-1 homolog (gcMASP-1) in the grass carp (Ctenopharyngodon idella). The full-length 3308-bp gcMASP-1 cDNA includes a 2160-bp open reading frame encoding a protein composed of 719 amino acids with epidermal growth factor-like, complement control protein, and trypsin-like domains...
May 4, 2017: Fish & Shellfish Immunology
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