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https://www.readbyqxmd.com/read/28415002/experimental-and-numerical-study-of-liquefied-natural-gas-lng-pool-spreading-and-vaporization-on-water
#1
Nirupama Gopalaswami, Konstantinos Kakosimos, Bin Zhang, Yi Liu, R Mentzer, M Sam Mannan
The investigation of pool spreading and vaporization phenomenon is an essential part of consequence analysis to determine the severity of LNG spills on water. In this study, release of LNG on water during marine operations is studied through experimental and numerical methods The study involves emulation of an LNG leak from transfer arms during side by side loading operations. The experimental part involves flow of LNG in a narrow trench filled with water and subsequent measurement of pool spreading and vaporization parameters...
April 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28408313/preventing-cardiovascular-heart-disease-promising-nutraceutical-and-non-nutraceutical-treatments-for-cholesterol-management
#2
REVIEW
T P Johnston, T A Korolenko, M Pirro, A Sahebkar
Hypercholesterolemia is one of the major risk factors for the development of cardiovascular disease. Atherosclerosis resulting from hypercholesterolemia causes many serious cardiovascular diseases. Statins are generally accepted as a treatment of choice for lowering low-density lipoprotein (LDL) cholesterol, which reduces coronary heart disease morbidity and mortality. Since statin use can be associated with muscle problems and other adverse symptoms, non-adherence and discontinuation of statin therapy often leads to inadequate control of plasma cholesterol levels and increased cardiovascular risk...
April 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28406929/hiv-aids-knowledge-attitudes-and-behaviour-of-persons-with-and-without-disabilities-from-the-uganda-demographic-and-health-survey-2011-differential-access-to-hiv-aids-information-and-services
#3
Julie Abimanyi-Ochom, Hasheem Mannan, Nora Ellen Groce, Joanne McVeigh
Uganda is among the first to use the Washington Group Short Set of Questions on Disability to identify persons with disabilities in its Demographic and Health Survey. In this paper, we review the HIV Knowledge, Attitudes and Behaviour component of the 2011 Ugandan Demographic and Health Survey, analysing a series of questions comparing those with and without disabilities in relation to HIV/AIDS knowledge, attitudes and practices. We found comparable levels of knowledge on HIV/AIDS for those with and those without disabilities in relation to HIV transmission during delivery (93...
2017: PloS One
https://www.readbyqxmd.com/read/28402840/high-molecular-weight-components-containing-n-linked-oligosaccharides-of-ascaris-suum-extract-inhibit-the-dendritic-cells-activation-through-dc-sign-and-mr
#4
Bruna C Favoretto, Adriana A C Casabuono, José A Portes-Junior, Jacqueline F Jacysyn, Alicia S Couto, Eliana L Faquim-Mauro
Helminths, as well as their secretory/excretory products, induce a tolerogenic immune microenvironment. High molecular weight components (PI) from Ascaris suum extract down-modulate the immune response against ovalbumin (OVA). The PI exerts direct effect on dendritic cells (DCs) independent of TLR 2, 4 and MyD88 molecule and, thus, decreases the T lymphocytes response. Here, we studied the glycoconjugates in PI and the role of C-type lectin receptors (CLRs), DC-SIGN and MR, in the modulation of DCs activity...
April 9, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28399957/mannan-oligosaccharide-prepartum-supplementation-effects-on-dairy-cow-colostrum-quality-and-quantity
#5
A Westland, R Martin, R White, J H Martin
Providing the neonatal calf with a sufficient quantity and quality of colostrum may optimise future health, performance and reduce the risk of morbidity. A 6-month double blind trial with 80 prepartum dairy cows was conducted to determine if supplementation with mannan oligosaccharide (MOS) influences colostrum quality, quantity and subsequent calf performance. The Holstein cross Friesian 80 cows (no heifers) were allocated into a control and treatment group at the point of drying off by previous lactation number and yield...
April 12, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28399864/predictors-of-dental-visits-among-primary-school-children-in-the-rural-australian-community-of-lithgow
#6
James Rufus John, Haider Mannan, Subrat Nargundkar, Mario D'Souza, Loc Giang Do, Amit Arora
BACKGROUND: Regular dental attendance is significant in maintaining and improving children's oral health and well-being. This study aims to determine the factors that predict and influence dental visits in primary school children residing in the rural community of Lithgow, New South Wales (NSW), Australia. METHODS: All six primary schools of Lithgow were approached to participate in a cross-sectional survey prior to implementing water fluoridation in 2014. Children aged 6-13 years (n = 667) were clinically examined for their oral health status and parents were requested to complete a questionnaire on fluoride history, diet, last dental visit, and socio-demographic characteristics...
April 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28367623/emerging-insights-for-better-delivery-of-chemicals-and-stem-cells-to-the-brain
#7
Abdul Mannan Baig
The human central nervous system and its vascularity has evolved a complex yet useful barricade, called the blood-brain barrier. The understanding of this barrier and the transport proteins that allow a selective access across it remains fundamental in designing chemicals and molecules that could cross it and prove therapeutically beneficial. After the recent findings of the brain-lymphatic link and the movement of chemical molecules from the central nervous system into general circulation, the model of the blood-brain barrier needs to be revisited...
April 3, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28362854/molecular-and-cellular-responses-of-the-pathogenic-fungus-lomentospora-prolificans-to-the-antifungal-drug-voriconazole
#8
Aize Pellon, Andoni Ramirez-Garcia, Idoia Buldain, Aitziber Antoran, Aitor Rementeria, Fernando L Hernando
The filamentous fungus Lomentospora (Scedosporium) prolificans is an emerging opportunistic pathogen associated with fatal infections in patients with disturbed immune function. Unfortunately, conventional therapies are hardly of any use against this fungus due to its intrinsic resistance. Therefore, we performed an integrated study of the L. prolificans responses to the first option to treat these mycoses, namely voriconazole, with the aim of unveiling mechanisms involved in the resistance to this compound...
2017: PloS One
https://www.readbyqxmd.com/read/28358942/negative-dielectrophoresis-spectroscopy-for-rare-analyte-quantification-in-biological-samples
#9
Syed Abdul Mannan Kirmani, Fleming Dackson Gudagunti, Logeeshan Velmanickam, Dharmakeerthi Nawarathna, Ivan T Lima
No abstract text is available yet for this article.
March 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28349070/diabetes-is-associated-with-increased-autoreactivity-of-mannan-binding-lectin
#10
Esben Axelgaard, Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen
Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or to altered self-tissue. Our group have previously shown direct effects of MBL on diabetes-induced kidney damage, and we hypothesized that MBL may cause autoactivation of the complement system via binding to neoepitopes induced by hyperglycemia...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28341045/exogenous-%C3%AE-mannanase-improves-feed-conversion-efficiency-and-reduces-somatic-cell-count-in-dairy-cattle
#11
T A Tewoldebrhan, J A D R N Appuhamy, J-J Lee, M Niu, S Seo, S Jeong, E Kebreab
Exogenous fibrolytic enzymes have been shown to be a promising way to improve feed conversion efficiency (FCE). β-Mannanase is an important enzyme digesting the polysaccharide β-mannan in hemicellulose. Supplementation of diets with β-mannanase to improve FCE has been more extensively studied in nonruminants than in ruminants. The objective of this study was to investigate the effects of β-mannanase supplementation on nutrient digestibility, FCE, and nitrogen utilization in lactating Holstein dairy cows...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28337025/prevalence-of-obesity-and-comorbid-eating-disorder-behaviors-in-south-australia-from-1995-to-2015
#12
F Q da Luz, A Sainsbury, H Mannan, S Touyz, D Mitchison, P Hay
BACKGROUND: Obesity and eating disorders are often studied and treated separately. While the increases in obesity prevalence are well known, examination of its co-occurrence with eating disorders, a problem also of public health concern, is important because eating disorder behaviors are known to contribute to obesity onset and maintenance, and vice versa. METHODS: Data from large cross-sectional representative statewide community samples of people in the years of 1995 (n=3001), 2005 (n=3047) and 2015 (n=3005) were analyzed...
April 18, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28330208/purification-and-characterization-of-%C3%AE-mannanase-from-aspergillus-terreus-and-its-applicability-in-depolymerization-of-mannans-and-saccharification-of-lignocellulosic-biomass
#13
Hemant Soni, Hemant Kumar Rawat, Brett I Pletschke, Naveen Kango
Aspergillus terreus FBCC 1369 was grown in solid-state culture under statistically optimized conditions. β-Mannanase was purified to apparent homogeneity by ultrafiltration, anion exchange and gel filtration chromatography. A purification factor of 10.3-fold was achieved, with the purified enzyme exhibiting specific activity of 53 U/mg protein. The purified β-mannanase was optimally active at pH 7.0 and 70 °C and displayed stability over a broad pH range of 4.0-8.0 and a 30 min half-life at 80 °C. The molecular weight of β-mannanase was calculated as ~49 kDa by SDS-PAGE...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327797/bacterial-immunostat-mycobacterium-tuberculosis-lipids-and-their-role-in-the-host-immune-response
#14
Adriano Queiroz, Lee W Riley
The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an infected human host. Accumulating evidence suggests that M. tuberculosis remodels the lipid composition of the cell wall as an adaptive mechanism against host-imposed stress. Some of these lipid species (trehalose dimycolate, diacylated sulphoglycolipid, and mannan-based lipoglycans) trigger an immunopathologic response, whereas others (phthiocerol dimycocerosate, mycolic acids, sulpholipid-1, and di-and polyacyltrehalose) appear to dampen the immune responses...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28325331/two-banana-cultivars-differ-in-composition-of-potentially-immunomodulatory-mannan-and-arabinogalactan
#15
Tânia M Shiga, Nicholas C Carpita, Franco Maria Lajolo, Beatriz Rosana Cordenunsi-Lysenko
Banana (Musa acuminata and M. acuminata x M. balbisiana) fruit cell walls are rich in mannans, homogalacturonans and xylogalacturonan, rhamnogalacturonan-I, and arabinogalactans, certain forms of which is considered to have immunomodulatory activity. The cultivars Nanicão and Thap Maeo represent two widely variants with respect to compositional differences in the forms of these polysaccharides. Nanicão has low amounts of mannan in the water-insoluble and water-soluble fraction. Both cultivars have high amounts of water-soluble arabinogalactan...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28324680/somatic-complications-of-epilepsy-surgery-over-25-years-at-a-single-center
#16
Inuka K Gooneratne, Shahidul Mannan, Jane de Tisi, Juan C Gonzalez, Andrew W McEvoy, Anna Miserocchi, Beate Diehl, Tim Wehner, Gail S Bell, Josemir W Sander, John S Duncan
INTRODUCTION: Epilepsy surgery is an effective treatment for refractory focal epilepsy. Risks of surgery need to be considered when advising individuals of treatment options. We describe the frequency and nature of physical adverse events associated with epilepsy surgery in a single center. MATERIAL AND METHODS: We reviewed the prospectively maintained records of adults who underwent epilepsy surgery at our center between 1990 and 2014 to identify peri/postsurgical adverse events...
March 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28318015/plasma-levels-of-masp-1-masp-3-and-map44-in-patients-with-type-2-diabetes-influence-of-glycaemic-control-body-composition-and-polymorphisms-in-the-masp1-gene
#17
S S Krogh, C B Holt, R Steffensen, K L Funck, P Høyem, E Laugesen, P L Poulsen, S Thiel, T K Hansen
Mounting evidence indicates that adverse activation of the complement system plays a role in the development of diabetic vascular complications. Plasma levels of the complement proteins mannan-binding lectin (MBL) and its associated serine proteases (MASP-1 and MASP-2) are elevated in diabetes. We hypothesized that single nucleotide polymorphisms (SNPs) in the MASP1 gene may contribute to altered plasma levels of the belonging gene products; MASP-1, MASP-3 and mannan-binding lectin-associated protein of 44 kDa (MAp44) in patients with type 2 diabetes...
March 20, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28317806/mycobacterium-lepraemurium-uses-tlr-6-and-mr-but-not-lipid-rafts-or-dc-sign-to-gain-access-into-mouse-macrophages
#18
Mayra Silva-Miranda, Patricia Arce-Paredes, Oscar Rojas-Espinosa
OBJECTIVE/BACKGROUND: Mycobacterium lepraemurium (MLM), the etiologic agent of murine leprosy, is an intracellular parasite of macrophages; the mechanism used by this bacterium to enter macrophages is not known. The fate of the MLM phagosome inside macrophages is also unknown. This study was conducted to investigate how MLM enters macrophages and to define the maturation process of MLM phagosome inside macrophages. MATERIALS AND METHODS: Peritoneal macrophages were incubated in the presence of mannan-bovine serum albumin (BSA), and antibodies to known macrophage receptors, including, anti-FcγRIII/RII (anti-CD16/32), anti-CD35 (anti-CR1), anti-TLR2, anti-TLR4, anti-TLR6, anti-CD14, and anti-dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317006/proteomic-data-on-enzyme-secretion-and-activity-in-the-bacterium-chitinophaga-pinensis
#19
Johan Larsbrink, Tina R Tuveng, Phillip B Pope, Vincent Bulone, Vincent G H Eijsink, Harry Brumer, Lauren S McKee
The secretion of carbohydrate-degrading enzymes by a bacterium sourced from a softwood forest environment has been investigated by mass spectrometry. The findings are discussed in full in the research article "Proteomic insights into mannan degradation and protein secretion by the forest floor bacterium Chitinophaga pinensis" in Journal of Proteomics by Larsbrink et al. ([1], doi: 10.1016/j.jprot.2017.01.003). The bacterium was grown on three carbon sources (glucose, glucomannan, and galactomannan) which are likely to be nutrient sources or carbohydrate degradation products found in its natural habitat...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28303635/incident-microalbuminuria-and-complement-factor-mannan-binding-lectin-associated-protein-19-in-people-with-newly-diagnosed-type-1-diabetes
#20
J A Ostergaard, S Thiel, I T Hoffmann-Petersen, P Hovind, H-H Parving, L Tarnow, P Rossing, T K Hansen
BACKGROUND: Evidence links the lectin pathway of complement activation to diabetic kidney disease. Upon carbohydrate-recognition by pattern-recognition molecules, e.g., mannan-binding lectin (MBL), the MBL-associated serine protease (MASP-2) is activated and initiates the complement cascade. The MASP2 gene encodes MASP-2 and the alternative splice product MBL-associated protein 19 (MAp19). Both MAp19 and MASP-2 circulate in complex with MBL. We tested the hypothesis that MAp19 and MASP-2 concentrations predict the risk of incident microalbuminuria...
March 16, 2017: Diabetes/metabolism Research and Reviews
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