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Dectin-1

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https://www.readbyqxmd.com/read/29668708/dectin-1-2-induced-autocrine-pge2-signaling-licenses-dendritic-cells-to-prime-th2-responses
#1
Maria M M Kaisar, Manuel Ritter, Carlos Del Fresno, Hulda S Jónasdóttir, Alwin J van der Ham, Leonard R Pelgrom, Gabriele Schramm, Laura E Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive potent Th2 responses, triggers DCs to produce prostaglandin E2 (PGE2), which subsequently-in an autocrine manner-induces OX40 ligand (OX40L) expression to license these DCs to drive Th2 responses. Mechanistically, SEA was found to promote PGE2 synthesis through Dectin-1 and Dectin-2, and via a downstream signaling cascade involving spleen tyrosine kinase (Syk), extracellular signal-regulated kinase (ERK), cytosolic phospholipase A2 (cPLA2), and cyclooxygenase 1 and 2 (COX-1 and COX-2)...
April 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29666621/the-role-of-aire-in-the-immunity-against-candida-albicans-in-a-model-of-human-macrophages
#2
Jose Antonio Tavares de Albuquerque, Pinaki Prosad Banerjee, Angela Castoldi, Royce Ma, Nuria Bengala Zurro, Leandro Hideki Ynoue, Christina Arslanian, Marina Uchoa Wall Barbosa-Carvalho, Joya Emilie de Menezes Correia-Deur, Fernanda Guimarães Weiler, Magnus Regios Dias-da-Silva, Marise Lazaretti-Castro, Luis Alberto Pedroza, Niels Olsen Saraiva Câmara, Emily Mace, Jordan Scott Orange, Antonio Condino-Neto
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene ( AIRE ). Patients with AIRE mutations are susceptible to Candida albicans infection and present with autoimmune disorders. We previously demonstrated that cytoplasmic AIRE regulates the Syk-dependent Dectin-1 pathway. In this study, we further evaluated direct contact with fungal elements, synapse formation, and the response of macrophage-like THP-1 cells to C...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29661910/myeloid-cell-deficiency-of-p38%C3%AE-p38%C3%AE-protects-against-candidiasis-and-regulates-antifungal-immunity
#3
Dayanira Alsina-Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González-Romero, Ester Díaz-Mora, Ana Risco, Miguel A Martín-Serrano, Carlos Del Fresno, Jorge Dominguez-Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz-Ezquerro, Ana Cuenda
Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate immune response to C. albicans We describe a new TAK1-TPL2-MKK1-ERK1/2 pathway in macrophages, which is activated by Dectin-1 engagement and positively regulated by p38γ/p38δ. In mice, p38γ/p38δ deficiency protects against C...
April 16, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29648784/design-of-mannose-functionalized-curdlan-nanoparticles-for-macrophage-targeted-sirna-delivery
#4
Tsogzolmaa Ganbold, Huricha Baigude
6-Amino-6-deoxy-curdlan is a promising nucleic acids carrier that efficiently delivers plasmid DNA as well as short interfering RNA (siRNA) to various cell lines. The highly reactive C6-NH2 groups of 6-amino-6-deoxy-curdlan prompt conjugation of various side groups including tissue targeting ligands to enhance cell type specific nucleic acid delivery to specific cell lines. Herein, to test primary cell targeting efficiency of curdlan derivative, we chemically conjugated a macrophage targeting ligand, mannose, to 6-amino-6-deoxy-curdlan...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29643192/characterizing-the-mechanisms-of-nonopsonic-uptake-of-cryptococci-by-macrophages
#5
Jenson Lim, Christopher J Coates, Paula I Seoane, Mariam Garelnabi, Leanne M Taylor-Smith, Pauline Monteith, Camille L Macleod, Claire J Escaron, Gordon D Brown, Rebecca A Hall, Robin C May
The pathogenic fungus Cryptococcus enters the human host via inhalation into the lung and is able to reside in a niche environment that is serum- (opsonin) limiting. Little is known about the mechanism by which nonopsonic phagocytosis occurs via phagocytes in such situations. Using a combination of soluble inhibitors of phagocytic receptors and macrophages derived from knockout mice and human volunteers, we show that uptake of nonopsonized Cryptococcus neoformans and C. gattii via the mannose receptor is dependent on macrophage activation by cytokines...
April 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29616193/a-comprehensive-in-silico-analysis-of-regulatory-snps-of-human-clec7a-gene-and-its-validation-as-genotypic-and-phenotypic-disease-marker-in-recurrent-vulvovaginal-infections
#6
Namarta Kalia, Manpreet Kaur, Sujata Sharma, Jatinder Singh
Recurrent Vulvovaginal infections (RVVI) are the commonly reported microbiological syndrome affecting millions of women globally. Various molecules of innate immune system are instrumental in clearance of these microbial pathogens, thus suggested as one of the most important contributing factor in determining the disease outcome. Dendritic cell-associated C-type lectin-1 (Dectin-1) is an important molecule of innate immunity that is primarily known for its role in antifungal defenses. However, role of dectin-1 in recognition of other pathogens is also documented...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29616088/retrospective-screening-of-microarray-data-to-identify-candidate-ifn-inducible-genes-in-a-htlv-1-transformed-model
#7
Alaa Refaat, Mohamed Owis, Sherif Abdelhamed, Ikuo Saiki, Hiroaki Sakurai
HuT-102 cells are considered one of the most representable human T-lymphotropic virus 1 (HTLV-1)-infected cell lines for studying adult T-cell lymphoma (ATL). In our previous studies, genome-wide screening was performed using the GeneChip system with Human Genome Array U133 Plus 2.0 for transforming growth factor-β-activated kinase 1 (TAK1)-, interferon regulatory factor 3 (IRF3)- and IRF4-regulated genes to demonstrate the effects of interferon-inducible genes in HuT-102 cells. Our previous findings demonstrated that TAK1 induced interferon inducible genes via an IRF3-dependent pathway and that IRF4 has a counteracting effect...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29610256/myeloid-differentiation-factor-88-myd88-and-il-1r1-signaling-contribute-to-resistance-to-coccidioides-immitis
#8
Suganya Viriyakosol, Lorraine Walls, Sharon Okamoto, Eyal Raz, David L Williams, Joshua Fierer
Rodents are a natural host for the dimorphic pathogenic fungi Coccidioides immitis and posadasii , and mice are a good model for human infection. Humans and rodents both express Dectin-1 and TLR2 on myeloid cells and those receptors collaborate to maximize the cytokine/chemokine responses to spherules (the tissue form of the fungi), and to formalin killed spherules (FKS). We showed that Dectin-1 is necessary for resistance to pulmonary coccidioidomycosis, but the importance of TLR2 in vivo is uncertain. MyD88 is the adapter protein for TLR2 and 4, and IL-1R1 and IL-18R1...
April 2, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29593493/low-fat-diet-with-caloric-restriction-reduces-white-matter-microglia-activation-during-aging
#9
Zhuoran Yin, Divya D Raj, Wandert Schaafsma, Roel A van der Heijden, Susanne M Kooistra, Aaffien C Reijne, Xiaoming Zhang, Jill Moser, Nieske Brouwer, Peter Heeringa, Chun-Xia Yi, Gertjan van Dijk, Jon D Laman, Erik W G M Boddeke, Bart J L Eggen
Rodent models of both aging and obesity are characterized by inflammation in specific brain regions, notably the corpus callosum, fornix, and hypothalamus. Microglia, the resident macrophages of the central nervous system, are important for brain development, neural support, and homeostasis. However, the effects of diet and lifestyle on microglia during aging are only partly understood. Here, we report alterations in microglia phenotype and functions in different brain regions of mice on a high-fat diet (HFD) or low-fat diet (LFD) during aging and in response to voluntary running wheel exercise...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29582549/microglial-immune-response-is-impaired-against-the-neurotropic-fungus-lomentospora-prolificans
#10
Aize Pellon, Andoni Ramirez-Garcia, Xabier Guruceaga, Alazne Zabala, Idoia Buldain, Aitziber Antoran, Juan Anguita, Aitor Rementeria, Carlos Matute, Fernando L Hernando
Lomentospora (Scedosporium) prolificans is an opportunistic pathogen capable of causing invasive infections in immunocompromised patients. The fungus is able to disseminate via the bloodstream finally arriving at the central nervous system (CNS) producing neurological symptoms and in many cases, patient death. In this context, microglial cells, which are the resident immune cells in the CNS, may play an important role in these infections. However, this aspect of anti-L. prolificans immunity has been poorly researched to date...
March 26, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29551572/flying-under-the-radar-histoplasma-capsulatum-avoidance-of-innate-immune-recognition
#11
REVIEW
Stephanie C Ray, Chad A Rappleye
The dimorphic fungal pathogen Histoplasma capsulatum takes advantage of the innate immune system, utilizing host macrophages as a proliferative niche while largely avoiding stimulation of signaling host receptors. As a result, innate immune cells are unable to control H. capsulatum on their own. Not all host phagocytes respond to H. capsulatum in the same way, with neutrophils and dendritic cells playing important roles in impeding fungal growth and initiating a protective TH 1 response, respectively. Dendritic cells prime T-cell differentiation after internalization of yeasts via VLA-5 receptors and subsequent degradation of the yeasts...
March 15, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29541075/overcoming-the-neonatal-limitations-of-inducing-germinal-centers-through-liposome-based-adjuvants-including-c-type-lectin-agonists-trehalose-dibehenate-or-curdlan
#12
Maria Vono, Christiane Sigrid Eberhardt, Elodie Mohr, Floriane Auderset, Dennis Christensen, Mirco Schmolke, Rhea Coler, Andreas Meinke, Peter Andersen, Paul-Henri Lambert, Beatris Mastelic-Gavillet, Claire-Anne Siegrist
Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable. Formulating antigens with potent adjuvants, including immunostimulators and delivery systems, is a demonstrated approach to enhance vaccine efficacy. Yet, adjuvants effective in adults may not meet the specific requirements for activating the early life immune system...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29540860/dectin-1-stimulates-il-33-expression-in-dendritic-cells-via-upregulation-of-irf4
#13
Dongjiao Wang, Sujun Gao, Jintong Chen, Yinghua Zhao, Yuxue Jiang, Xiao Chu, Xiaohua Wang, Ning Liu, Tianxue Qin, Qing Yi, Ying Yue, Siqing Wang
Interleukin-33 (IL-33) is a potent contributor to antiviral immune responses and antitumor immunity. We recently discovered that IL-33 is overexpressed in dectin-1-activated dendritic cells (DCs). However, mechanisms of dectin-1-induced IL-33 expression in DCs remain elusive. Curdlan, an agonist of dectin-1, was used to mature DCs in this study. We found that dectin-1-induced IL-33 expression in DCs relies on Syk and Raf-1 pathways. By using nuclear factor (NF)-κB inhibitors, we also found that dectin-1-induced IL-33 expression relies on NF-κB signaling...
March 14, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29535708/dectin-1-positive-dendritic-cells-expand-after-infection-with-leishmania-major-parasites-and-represent-promising-targets-for-vaccine-development
#14
Nicole Zimara, Menberework Chanyalew, Abraham Aseffa, Ger van Zandbergen, Bernd Lepenies, Maximilian Schmid, Richard Weiss, Anne Rascle, Anja Kathrin Wege, Jonathan Jantsch, Valentin Schatz, Gordon D Brown, Uwe Ritter
Resistant mouse strains mount a protective T cell-mediated immune response upon infection with Leishmania (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-γ production, while susceptibility is associated with an IL-4-dependent Th2-type response. It has been shown that dermal dendritic cells are crucial for inducing protective Th1-mediated immunity. Additionally, there is growing evidence that C-type lectin receptor (CLR)-mediated signaling is involved in directing adaptive immunity against pathogens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29522806/pattern-recognition-receptors-in-fungal-immunity
#15
REVIEW
Emmanuel C Patin, Aiysha Thompson, Selinda J Orr
Over the last decade, invasive fungal infections have emerged as a growing threat to human health worldwide and novel treatment strategies are urgently needed. In this context, investigations into host-pathogen interactions represent an important and promising field of research. Antigen presenting cells such as macrophages and dendritic cells are strategically located at the frontline of defence against potential invaders. Importantly, these cells express germline encoded pattern recognition receptors (PRRs), which sense conserved entities from pathogens and orchestrate innate immune responses...
March 8, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29511432/vitamin-d-enhances-resistance-to-aspergillus-fumigatus-in-mice-via-inhibition-of-excessive-autophagy
#16
Jingjing Dai, Yong Liang, Honglin Li, Wubi Zhou, Bing Wang, Aijia Gong, Rongbo Zhang
The role of vitamin D in the regulation of lung immune defense and inflammatory response has attracted more and more attention. Vitamin D deficiency is closely related to respiratory tract infections. However, few studies have elucidated the mechanism of vitamin D deficiency on host pulmonary resistance to Aspergillus fumigatus ( A. fumigatus ). In this paper, the role of autophagy and Treg regulation in the treatment of rat models of A. fumigatus infection with vitamin D was investigated. We intratracheally injected the A...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29511377/differences-in-c-type-lectin-receptors-and-their-adaptor-molecules-in-the-peritoneal-fluid-of-patients-with-endometriosis-and-gynecologic-cancers
#17
Seung Geun Yeo, Yong Sung Won, Sang Hoon Kim, Dong Choon Park
Endometriosis, although not malignant, has clinically demonstrated properties of invasiveness and metastasis. The pathogenesis of endometriosis, however, has not yet been elucidated. The immunological differences between endometriosis and malignant gynecologic tumors were analyzed by assessing C-type lectin receptors, which are associated with innate immunity, and immunoglobulin secretion, which is associated with B cell adaptive immunity, in the peritoneal fluid of these patients. Peritoneal fluid samples were obtained from 42 patients with benign masses (control group), 38 with endometriosis, and 43 with gynecologic (ovarian, uterine, and cervical) cancers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29500637/rna-seq-profile-reveals-th-1-and-th-17-type-of-immune-responses-in-mice-infected-systemically-with-aspergillus-fumigatus
#18
Jata Shankar, Gustavo C Cerqueira, Jennifer R Wortman, Karl V Clemons, David A Stevens
With the increasing numbers of immunocompromised hosts, Aspergillus fumigatus emerges as a lethal opportunistic fungal pathogen. Understanding innate and acquired immunity responses of the host is important for a better therapeutic strategy to deal with aspergillosis patients. To determine the transcriptome in the kidneys in aspergillosis, we employed RNA-Seq to obtain single 76-base reads of whole-genome transcripts of murine kidneys on a temporal basis (days 0; uninfected, 1, 2, 3 and 8) during invasive aspergillosis...
March 2, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29497419/c-type-lectin-like-receptors-as-emerging-orchestrators-of-sterile-inflammation-represent-potential-therapeutic-targets
#19
REVIEW
Elise Chiffoleau
Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid cells, have gained increasing attention for their role in the fine tuning of both innate and adaptive immunity. Not only CTLRs recognize pathogen-derived ligands to protect against infection but also endogenous ligands such as self-carbohydrates, proteins, or lipids to control homeostasis and tissue injury. Interestingly, CTLRs act as antigen-uptake receptors via their carbohydrate-recognition domain for internalization and subsequent presentation to T-cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29491277/%C3%AE-glucan-in-foods-and-its-physiological-functions
#20
Ayaka Nakashima, Koji Yamada, Osamu Iwata, Ryota Sugimoto, Kohei Atsuji, Taro Ogawa, Naoko Ishibashi-Ohgo, Kengo Suzuki
β-Glucans are a class of polysaccharides consisting of D-glucose units that are polymerized primarily via the β-1,3 glycosidic bonds, in addition to the β-1,4 and/or β-1,6 bonds. They are present in various food products such as cereals, mushrooms, and seaweeds and are known for their numerous effects on the human body, depending on their structures, which are diverse. The major physicochemical properties of β-glucans include their antioxidant property, which is responsible for the scavenging of reactive oxygen species, and their role as dietary fiber for preventing the absorption of cholesterol, for promoting egestion, and for producing short-chain fatty acids in the intestine...
2018: Journal of Nutritional Science and Vitaminology
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