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Dectin-1

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https://www.readbyqxmd.com/read/27912071/classical-and-alternative-macrophages-have-impaired-function-during-acute-and-chronic-hiv-1-infection
#1
Leonardo J Galvão-Lima, Milena S Espíndola, Luana S Soares, Fabiana A Zambuzi, Maira Cacemiro, Caroline Fontanari, Valdes R Bollela, Fabiani G Frantz
OBJECTIVES: Three decades after HIV recognition and its association with AIDS development, many advances have emerged - especially related to prevention and treatment. Undoubtedly, the development of Highly Active Antiretroviral Therapy (HAART) dramatically changed the future of the syndrome that we know today. In the present study, we evaluate the impact of HAART on macrophage function and its relevance to HIV pathogenesis. METHODS: PBMCs were isolated from blood samples and monocytes (CD14+ cells) were purified...
November 29, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27898740/kluyveromyces-marxianus-and-saccharomyces-boulardii-induce-distinct-levels-of-dendritic-cell-cytokine-secretion-and-significantly-different-t-cell-responses-in-vitro
#2
Ida M Smith, Adam Baker, Jeffrey E Christensen, Teun Boekhout, Hanne Frøkiær, Nils Arneborg, Lene Jespersen
Interactions between members of the intestinal microbiota and the mucosal immune system can significantly impact human health, and in this context, fungi and food-related yeasts are known to influence intestinal inflammation through direct interactions with specialized immune cells in vivo. The aim of the present study was to characterize the immune modulating properties of the food-related yeast Kluyveromyces marxianus in terms of adaptive immune responses indicating inflammation versus tolerance and to explore the mechanisms behind the observed responses...
2016: PloS One
https://www.readbyqxmd.com/read/27889356/role-of-ptx3-in-corneal-epithelial-innate-immunity-against-aspergillus-fumigatus-infection
#3
Jie Zhang, Guiqiu Zhao, Jing Lin, Chengye Che, Cui Li, Nan Jiang, Liting Hu, Qian Wang
Pentraxin3 (PTX3), a member of long pentraxin family, plays a non-redundant role in human humoral innate immunity. However, whether PTX3 is expressed by corneal epithelial cells and its role during corneal fungi infection has not yet been investigated. To identify the presence of PTX3 in cornea, the possible mechanisms involved in its expression, and also the effects on corneal anti-fungi innate immune response, clinic human corneal tissues and cultured human corneal epithelial cells (HCECs) were resorted. PTX3 mRNA and protein were detected in corneal samples and cultured HCECs, which was significantly up-regulated after exposing to Aspergillus fumigatus (A...
November 23, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27872213/autocrine-type-i-ifn-signaling-in-dendritic-cells-stimulated-with-fungal-%C3%AE-glucans-or-lipopolysaccharide-promotes-cd8-t-cell-activation
#4
Nargess Hassanzadeh-Kiabi, Alberto Yáñez, Ivy Dang, Gislâine A Martins, David M Underhill, Helen S Goodridge
Type I IFNs are key mediators of immune defense against viruses and bacteria. Type I IFNs were also previously implicated in protection against fungal infection, but their roles in antifungal immunity have not been thoroughly investigated. A recent study demonstrated that bacterial and fungal β-glucans stimulate IFN-β production by dendritic cells (DCs) following detection by the Dectin-1 receptor, but the effects of β-glucan-induced type I IFNs have not been defined. We investigated whether type I IFNs regulate CD8 T cell activation by fungal β-glucan particle-stimulated DCs...
November 21, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27852745/dectin-1-plays-an-important-role-in-house-dust-mite-induced-allergic-airway-inflammation-through-the-activation-of-cd11b-dendritic-cells
#5
Takashi Ito, Koichi Hirose, Ayako Norimoto, Tomohiro Tamachi, Masaya Yokota, Aiko Saku, Hiroaki Takatori, Shinobu Saijo, Yoichiro Iwakura, Hiroshi Nakajima
It is well known that sensitization against fungi is closely associated with severity of asthma. Dectin-1 (gene symbol Clec7a), a C-type lectin receptor, recognizes the fungal cell wall component β-glucan, as well as some component(s) in house dust mite (HDM) extract. However, the roles of Dectin-1 in HDM-induced allergic airway inflammation remain unclear. In this study, we used Dectin-1-deficient (Clec7a(-/-)) mice to examine whether Dectin-1 is involved in HDM-induced allergic airway inflammation. We found that HDM-induced eosinophil and neutrophil recruitment into the airways was significantly attenuated in Clec7a(-/-) mice compared with that in wild-type mice...
November 16, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27849179/%C3%A3-glucan-unmasking-in-some-candida-albicans-mutants-correlates-with-increases-in-cell-wall-surface-roughness-and-decreases-in-cell-wall-elasticity
#6
Sahar Hasim, David P Allison, Scott T Retterer, Alex Hopke, Robert T Wheeler, Mitchel J Doktycz, Todd B Reynolds
Candida albicans is among the most common human fungal pathogens, causing a broad range of infections including life threatening systemic infections. The cell wall of C. albicans is the interface between the fungus and the innate immune system. The cell wall is composed of an outer layer enriched in mannosylated glycoproteins (mannan) and an inner layer enriched in ß- (1, 3)-glucan and chitin. Detection of C. albicans by Dectin-1, a C-type signaling lectin specific for ß- (1, 3)-glucan, is important for the innate immune system to recognize systemic fungal infections...
November 14, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27814595/particulate-beta-glucan-induces-early-and-late-phagosomal-maturation-in-murine-macrophages
#7
Nida Fatima, Tarun Upadhyay, Deepak Sharma, Rolee Sharma
Beta-glucans are carbohydrates (glucose polymers) found in the cell walls of fungi, yeast, algae, lichens, and plants such as oats and barley. Beta-glucans bind to glucan receptor on phagocytic cells and modify these cells to become "immunologically active" by generating a variety of innate immune responses. Particulate beta-glucan has been specifically shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS)...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27807909/induction-of-humoral-and-cellular-immune-response-to-hepatitis-b-virus-hbv-vaccine-can-be-upregulated-by-cpg-oligonucleotides-complexed-with-dectin-1-ligand
#8
H Ito, T Ando, M Nakamura, H Ishida, A Kanbe, K Kobiyama, T Yamamoto, K J Ishii, A Hara, M Seishima, T Ishikawa
A persistent hepatitis B virus (HBV) infection is characterized by a lack of or a weak immune response to HBV, which may be reflective of tolerance to HBV. Efficient induction of HBV-specific immune response leads to the clearance of HBV in patients with a chronic HBV infection. CpG oligodeoxynucleotides (ODN) has a powerful adjuvant effect in HBV vaccination. A recent report demonstrated that the immunization by B/K CpG ODN (K3) wrapped by the nonagonistic Dectin-1 ligand, schizophyllan (SPG), namely K3-SPG, was more effective in the induction of antigen-specific immune response than that by K3...
November 3, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27803850/the-role-of-dectin-1-raf-1-signal-cascade-in-innate-immune-of-human-corneal-epithelial-cells-against-aspergillus-fumigatus-infection
#9
Gui-Qiu Zhao, Jing Lin, Li-Ting Hu, Xiao-Ni Yin, Qian Wang, Qiang Xu, Hui Li
AIM: To investigate the expression of the v-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) and its role in the innate immune response of human corneal epithelial cells (HCECs) infected by Aspergillus fumigatus. METHODS: HCECs were cultured in vitro. They were randomly divided into 4 groups, including control group, Aspergillus fumigatus group, GW5074 (an inhibitor of Raf-1) group and Laminarin [an inhibitor of Dendriti-cell-associated C-type lectin 1 (Dectin-1)] group...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27793997/age-specific-adjuvant-synergy-dual-tlr7-8-and-mincle-activation-of-human-newborn-dendritic-cells-enables-th1-polarization
#10
Simon D van Haren, David J Dowling, Willemina Foppen, Dennis Christensen, Peter Andersen, Steven G Reed, Robert M Hershberg, Lindsey R Baden, Ofer Levy
Due to functionally distinct cell-mediated immunity, newborns and infants are highly susceptible to infection with intracellular pathogens. Indeed, neonatal Ag-presenting dendritic cells (DCs) demonstrate impaired Th1 responses to many candidate adjuvants, including most TLR agonists (TLRAs). Combination adjuvantation systems may provide enhanced immune activation but have typically been developed without regard to the age of the target population. We posited that distinct combinations of TLRAs and C-type lectin receptor agonists may enhance Th1 responses of newborn DCs...
October 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27784631/structural-and-functional-annotation-of-human-fam26f-a-multifaceted-protein-having-a-critical-role-in-the-immune-system
#11
Uzma Malik, Aneela Javed, Amjad Ali, Kashif Asghar
BACKGROUND: Human immune system is a complex amalgam of a greatly diverse ensemble comprising of various cellular and non-cellular components, including proteins. FAM26F (family with sequence similarity 26, member F) is a relatively recently identified gene reported to play important role in diverse immune responses. Numerous studies have reported FAM26F to be differentially expressed in several viral, bacterial and parasitic infections, in certain pathophysiological conditions such as heart and liver transplantation, and in several cancers...
January 15, 2017: Gene
https://www.readbyqxmd.com/read/27780012/lectin-receptors-expressed-on-myeloid-cells
#12
Gordon D Brown, Paul R Crocker
Lectins recognize a diverse array of carbohydrate structures and perform numerous essential biological functions. Here we focus on only two families of lectins, the Siglecs and C-type lectins. Triggering of intracellular signaling cascades following ligand recognition by these receptors can have profound effects on the induction and modulation of immunity. In this chapter, we provide a brief overview of each family and then focus on selected examples that highlight how these lectins can influence myeloid cell functioning in health and disease...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27755569/1-25-oh-2d3-and-vdr-signaling-pathways-regulate-the-inhibition-of-dectin-1-caused-by-cyclosporine-a-in-response-to-aspergillus-fumigatus-in-human-corneal-epithelial-cells
#13
Yiping Xia, Guiqiu Zhao, Jing Lin, Cui Li, Lin Cong, Nan Jiang, Qiang Xu, Qian Wang
BACKGROUND: The objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A. fumigatus) and to investigate the molecular mechanisms of the inhibition. METHODS: Immortalized human corneal epithelial cells (HCECs) were pretreated with 1,25(OH)2D3 and VDR inhibitor for 1 h, and then they were pretreated with CsA for 12h. After these pretreatments, the HCECs were stimulated with A...
2016: PloS One
https://www.readbyqxmd.com/read/27701922/myeloperoxidase-deficiency-enhances-zymosan-phagocytosis-associated-with-up-regulation-of-surface-expression-of-cd11b-in-mouse-neutrophils
#14
Kenta Fujimoto, Takehiro Motowaki, Naoya Tamura, Yasuaki Aratani
Myeloperoxidase (MPO), a major component of neutrophils, catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride anion. Phagocytosis is a critical event induced by neutrophils for host defense and inflammation. Interestingly, we found that MPO-deficient (MPO(-/-)) neutrophils engulfed larger amounts of zymosan than wild-type neutrophils. Blocking of the CD11b subunit of complement receptor 3 (CR3) as well as inhibition of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) dramatically reduced zymosan phagocytosis...
October 4, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27693847/lentinan-produces-a-robust-antidepressant-like-effect-via-enhancing-the-prefrontal-dectin-1-ampa-receptor-signaling-pathway
#15
Hongkun Bao, Lijuan Sun, Ying Zhu, Pengzhan Ran, Weihong Hu, Keming Zhu, Bai Li, Yangyang Hou, Jun Nie, Tangxin Gao, Liping Shan, Kai Du, Shangyong Zheng, Bingrong Zheng, Chunjie Xiao, Jing Du
Lentinan (LNT) is an immune regulator and its potential and mechanism for the treatment of mood disorder is of our interest. Dectin-1 is a β-glucan (including LNT) receptor that regulates immune functions in many immune cell types. Cumulative evidence has suggested that the glutamatergic system seems to play an important role in the treatment of depression. Here, we studied the antidepressant-like effects of LNT and its therapeutical target in regulating the functions of AMPA receptors. We found that 60min treatment with LNT leads to a significant antidepressant-like effect in the tail suspension test (TST) and the forced swim test (FST) in mice...
September 28, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27688795/fungal-cell-wall-agents-and-bacterial-lipopolysaccharide-in-organic-dust-as-possible-risk-factors-for-pulmonary-sarcoidosis
#16
Sanja Stopinšek, Alojz Ihan, Barbara Salobir, Marjeta Terčelj, Saša Simčič
BACKGROUND: Composition of organic dust is very complex, involving particles of microbial, animal and plant origin. Several environmental exposure studies associate microbial cell wall agents in organic dust with various respiratory symptoms and diseases. The aim of the present study was to investigate the in vitro effects of the co-exposure of fungal cell wall agents (FCWAs) and bacterial lipopolysaccharide (LPS) on inflammatory immune responses of peripheral blood mononuclear cells (PBMCs) from patients with pulmonary sarcoidosis...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27645024/fam26f-an-enigmatic-protein-having-a-complex-role-in-the-immune-system
#17
Uzma Malik, Aneela Javed
Mammalian immune system is a complex amalgam of diverse cellular and noncellular components such as cytokines, receptors and co-receptors. FAM26F (family with sequence similarity 26, member F) is a recently identified tetraspanin-like membrane glycoprotein which is predicted to make homophilic interactions and potential synapses between several immune cells including CD4(+), CD8(+), NK, dendritic cells and macrophages. Various whole transcriptome analyses have demonstrated the differential expression of FAM26F in several bacterial, viral and parasitic infections, in certain pathophysiological conditions such as liver and heart transplantation, and in various cancers...
September 19, 2016: International Reviews of Immunology
https://www.readbyqxmd.com/read/27620493/galectin-3-binds-highly-galactosylated-igg1-and-is-crucial-for-the-igg1-complex-mediated-inhibition-of-c5areceptor-induced-immune-responses
#18
Kerstin A Heyl, Christian M Karsten, Hortense Slevogt
Changes in the glycosylation of immunoglobulins have been shown to modulate immune homeostasis and disease pathology. In this sense it has been shown that highly galactosylated but not agalactosylated IgG1 immune complexes (ICs) inhibit C5aR-mediated pro-inflammatory immune responses via the assembly of FcγRIIB-Dectin-1 receptor complexes. In this study we demonstrated that Galectin-3, a galactose-binding lectin that is known to cross-link proteins on cell-surfaces via binding their N-glycans, bound to highly-galactosylated, but not agalactosylated IgG1...
October 7, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27600310/dectin-1-predicts-adverse-postoperative-prognosis-of-patients-with-clear-cell-renal-cell-carcinoma
#19
Yu Xia, Li Liu, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27595442/targeting-dendritic-cells-in-humanized-mice-receiving-adoptive-t-cells-via-monoclonal-antibodies-fused-to-flu-epitopes
#20
John P Graham, Pierre Authie, Chun I Yu, Sandra M Zurawski, Xiao-Hua Li, Florentina Marches, Anne-Laure Flamar, Aditi Acharya, Jacques Banchereau, A Karolina Palucka
The targeting of vaccine antigens to antigen presenting cells (APC), such as dendritic cells (DCs), is a promising strategy for boosting vaccine immunogenicity and, in turn, protective and/or therapeutic efficacy. However, in vivo systems are needed to evaluate the potential of this approach for testing human vaccines. To this end, we examined human CD8(+) T-cell expansion to novel DC-targeting vaccines in vitro and in vivo in humanized mice. Vaccines incorporating the influenza matrix protein-1 (FluM1) antigen fused to human specific antibodies targeting different DC receptors, including DEC-205, DCIR, Dectin-1, and CD40, elicited human CD8(+) T-cell responses, as defined by the magnitude of specific CD8(+) T-cells to the targeted antigen...
September 22, 2016: Vaccine
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