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Dectin-1

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https://www.readbyqxmd.com/read/29901822/malt1-blocks-il-1%C3%AE-production-by-macrophages-in-vitro-and-limits-dextran-sodium-sulfate-induced-intestinal-inflammation-in-vivo
#1
Mahdis Monajemi, Yvonne C F Pang, Saelin Bjornson, Susan C Menzies, Nico van Rooijen, Laura M Sly
This study tested the hypothesis that Malt1 deficiency in macrophages contributes to dextran sodium sulfate (DSS)-induced intestinal inflammation in Malt1-deficient mice. In people, combined immunodeficiency caused by a homozygous mutation in the MALT1 gene is associated with increased susceptibility to bacterial infections and chronic inflammation, including severe inflammation along the gastrointestinal tract. The consequences of Malt1 deficiency have largely been attributed to its role in lymphocytes, but Malt1 is also expressed in macrophages, where it is activated downstream of TLR4 and dectin-1...
June 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29897456/%C3%AE-glucan-induced-cooperative-oligomerization-of-dectin-1-c-type-lectin-like-domain
#2
Hari P Dulal, Yoshiyuki Adachi, Naohito Ohno, Yoshiki Yamaguchi
Dectin-1 is a C-type lectin-like pattern recognition receptor that recognizes β(1-3)-glucans present on non-self pathogens. It is of great importance in innate immunity to understand the mechanism whereby Dectin-1 senses β(1-3)-glucans and induces intracellular signaling. In this study, we characterize the ligand binding and ligand-induced oligomerization of murine Dectin-1 using its C-type lectin-like domain (CTLD). Interaction of CTLD with laminarin, a β-glucan ligand, induced a tetramer of CTLD, as evidenced by size exclusion chromatography and multi-angle light scattering...
April 20, 2018: Glycobiology
https://www.readbyqxmd.com/read/29896200/protein-deiminase-4-and-cr3-regulate-aspergillus-fumigatus-and-%C3%AE-glucan-induced-neutrophil-extracellular-trap-formation-but-hyphal-killing-is-dependent-only-on-cr3
#3
Heather L Clark, Serena Abbondante, Martin S Minns, Elyse N Greenberg, Yan Sun, Eric Pearlman
Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone citrullination. In the current study, we examined the role of PAD4 and NETosis following activation of neutrophils by A. fumigatus hyphal extract or cell wall β-glucan (curdlan) and found that both induced NET release by human and murine neutrophils...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29875204/an-increase-in-lrrk2-suppresses-autophagy-and-enhances-dectin-1-induced-immunity-in-a-mouse-model-of-colitis
#4
Tetsuya Takagawa, Atsushi Kitani, Ivan Fuss, Beth Levine, Steven R Brant, Inga Peter, Masaki Tajima, Shiro Nakamura, Warren Strober
The LRRK2/MUC19 gene region constitutes a high-risk genetic locus for the occurrence of both inflammatory bowel diseases (IBDs) and Parkinson's disease. We show that dendritic cells (DCs) from patients with Crohn's disease (CD) and lymphoblastoid cell lines derived from patients without CD but bearing a high-risk allele (rs11564258) at this locus as heterozygotes exhibited increased LRRK2 expression in vitro. To investigate the immunological consequences of this increased LRRK2 expression, we conducted studies in transgenic mice overexpressing Lrrk2 and showed that these mice exhibited more severe colitis induced by dextran sodium sulfate (DSS) than did littermate control animals...
June 6, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29868018/fluorescent-tracking-of-yeast-division-clarifies-the-essential-role-of-spleen-tyrosine-kinase-in-the-intracellular-control-of-candida-glabrata-in-macrophages
#5
Zeina Dagher, Shuying Xu, Paige E Negoro, Nida S Khan, Michael B Feldman, Jennifer L Reedy, Jenny M Tam, David B Sykes, Michael K Mansour
Macrophages play a critical role in the elimination of fungal pathogens. They are sensed via cell surface pattern-recognition receptors and are phagocytosed into newly formed organelles called phagosomes. Phagosomes mature through the recruitment of proteins and lysosomes, resulting in addition of proteolytic enzymes and acidification of the microenvironment. Our earlier studies demonstrated an essential role of Dectin-1-dependent activation of spleen tyrosine kinase (Syk) in the maturation of fungal containing phagosomes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29867934/exposure-of-intestinal-epithelial-cells-to-short-and-long-chain-fructo-oligosaccharides-and-cpg-oligodeoxynucleotides-enhances-peanut-specific-t-helper-1-polarization
#6
Simone M Hayen, Henny G Otten, Saskia A Overbeek, André C Knulst, Johan Garssen, Linette E M Willemsen
Background: Non-digestible oligosaccharides promote colonization of beneficial gut bacteria and have direct immunomodulatory effects. Apical exposure of intestinal epithelial cells (IECs) to short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) in a transwell co-culture model enhanced the CpG-induced (TLR-9 ligand) T helper 1 (Th1) phenotype and regulatory IL-10 response of underlying peripheral mononuclear cells (PBMCs) of healthy donors. scGOS is derived from lactose and may pose risks in severe cow's milk allergic patients, and scFOS/lcFOS may be an alternative...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29864141/defects-in-intracellular-trafficking-of-fungal-cell-wall-synthases-lead-to-aberrant-host-immune-recognition
#7
Shannon K Esher, Kyla S Ost, Maria A Kohlbrenner, Kaila M Pianalto, Calla L Telzrow, Althea Campuzano, Connie B Nichols, Carol Munro, Floyd L Wormley, J Andrew Alspaugh
The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and composition, upon entering the host. This cell wall remodeling is essential for host immune avoidance by this pathogen. In a genetic screen for mutants with changes in their cell wall, we identified a novel protein, Mar1, that controls cell wall organization and immune evasion. Through phenotypic studies of a loss-of-function strain, we have demonstrated that the mar1Δ mutant has an aberrant cell surface and a defect in polysaccharide capsule attachment, resulting in attenuated virulence...
June 4, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29863879/entrapping-of-nanoparticles-in-yeast-cell-wall-microparticles-for-macrophage-targeted-oral-delivery-of-cabazitaxel
#8
Tianyang Ren, Jingxin Gou, Wanxiao Sun, Xiaoguang Tao, Xinyi Tan, Puxiu Wang, Yu Zhang, Haibing He, Tian Yin, Xing Tang
In this work, a nano-in-micro carrier was constructed by loading polymer-lipid hybrid nanoparticles (NPs) into porous and hollow yeast cell wall microparticles (YPs) for macrophage-targeted oral delivery of cabazitaxel (CTX). The YPs, primarily composed of natural β-1,3-D-glucan, can be recognized by the apical membrane receptor, dectin-1, which has a high expression on macrophages and intestinal M cells. By combining electrostatic force-driven self-deposition with solvent hydration/lyophilization methods, the positively charged NPs loaded with CTX or fluorescence probes were efficiently packaged into YPs, as verified by scanning electron microscope (SEM), atomic force mircoscope (AFM) and confocal laser scanning microscopy (CLSM) images...
June 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29780375/effect-of-artinm-on-human-blood-cells-during-infection-with-paracoccidioides-brasiliensis
#9
Luciana P Ruas, Livia M Genaro, Amauri S Justo-Junior, Lilian O Coser, Lívia F de Castro, Plinio Trabasso, Ronei L Mamoni, Maria-Cristina Roque-Barreira, Maria-Heloisa S L Blotta
Infections caused by fungi are prominent in our environment and can be potentially fatal. paracoccidioidomycosis (PCM), caused by fungi of the Paracoccidioides genus, is the most frequent systemic mycosis in Brazil and the main cause of death among immunocompetent individuals. The antifungal therapy for PCM is usually effective but side effects and relapses are often reported. The latter could be avoided with alternative or complementary therapies aimed at boosting the immune response to combat this pathogen...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29775695/pulsatilla-decoction-inhibits-candida-albicans-proliferation-and-adhesion-in-a-mouse-model-of-vulvovaginal-candidiasis-via-the-dectin-1-signaling-pathway
#10
Lilin Yang, Haiwang Wu, Weiyu Qiu, Longyi Guo, Xin Du, Qingying Yu, Jie Gao, Songping Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Pulsatilla decoction (PD) is a classical prescription in Traditional Chinese Medicine (TCM) and has been reported to have inhibitory effects on Candida albicans proliferation. STUDY AIM: To investigate the therapeutic effects of PD in the treatment of Vulvovaginal candidiasis (VVC) and elucidate the potential mechanism. MATERIALS AND METHODS: Female BALB/c mice (N = 90) were randomized to six treatment groups, including the Control group, Model group, three PD groups and Fluconazole group which served as a positive control (20 mg/kg weekly)...
May 24, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29763702/immunostimulant-effects-and-potential-application-of-%C3%AE-glucans-derived-from-marine-yeast-debaryomyces-hansenii-in-goat-peripheral-blood-leucocytes
#11
Noé Medina-Córdova, Martha Reyes-Becerril, Felipe Ascencio, Thelma Castellanos, Angel I Campa-Córdova, Carlos Angulo
Debaryomyces hansenii has been described to be effective probiotic and immunostimulatory marine yeast in fish. Nonetheless, to the best of our knowledge, it has been not assayed in ruminants. This study attempts to describe the immunostimulatory effects of its β-glucan content through in vitro assays using goat peripheral blood leukocytes at 24 h of stimulation. The structural characterization of yeast glucans by proton nuclear magnetic resonance indicated structures containing (1-6)-branched (1-3)-β-D-glucan...
May 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29746940/nlrp3-inflammasome-is-involved-in-the-recognition-of-paracoccidioides-brasiliensis-by-human-dendritic-cells-and-in-the-induction-of-th17-cells
#12
Lívia Furquim de Castro, Larissa Nara Alegrini Longhi, Munir Regini Paião, Amauri da Silva Justo-Júnior, Marcelo Bispo de Jesus, Maria Heloisa de Souza Lima Blotta, Ronei Luciano Mamoni
OBJECTIVES: To investigate the involvement of NLRP3 in the effector functions of human dendritic cells (DCs) in response to Paracoccidioides brasiliensis yeast cells (Pb) and to evaluate its role in the modulation of the adaptive immune response. METHODS: DCs were differentiated from purified peripheral blood monocytes and analyzed in relation to the participation of TLR-2, dectin-1, and Syk in Pb recognition, as well as, the indirect mechanisms (Reactive Oxygen Species production, endosome acidification, or K+ efflux) involved in NLRP3 inflammasome activation after the stimulus with Pb...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29725603/stimulation-of-dectin-1-and-dectin-2-during-parenteral-immunization-but-not-mincle-induces-secretory-iga-in-intestinal-mucosa
#13
Alina S Dzharullaeva, Amir I Tukhvatulin, Alina S Erokhova, Alina S Bandelyuk, Nikita B Polyakov, Andrey I Solovyev, Natalia A Nikitenko, Dmitry V Shcheblyakov, Boris S Naroditsky, Denis Y Logunov, Alexander L Gintsburg
Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize adaptive immune reactions. Effects of Syk-coupled lectin receptor agonists as adjuvants to induce mucosal immune reactions during parenteral immunization are not fully studied...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29722096/the-14th-international-workshops-on-opportunistic-protists-iwop-14
#14
Melanie T Cushion, Andrew H Limper, Aleksey Porollo, Vivian E Saper, Anthony P Sinai, Louis M Weiss
The 14th International Workshops on Opportunistic Protists (IWOP-14) was held August 10-12, 2017 in Cincinnati, OH, USA. The IWOP meetings focus on opportunistic protists (OIs); for example, free-living amoebae, Pneumocystis spp., Cryptosporidium spp., Toxoplasma, the Microsporidia, and kinetoplastid flagellates. The highlights of Pneumocystis spp. research included the reports of primary homothallism for mating; a potential requirement for sexual replication in its life cycle; a new antigen on the surface of small asci; roles for CLRs, Dectin-1, and Mincle in host responses; and identification of MSG families and mechanisms used for surface variation...
May 3, 2018: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/29696023/c-type-lectin-receptors-in-asthma
#15
REVIEW
Sabelo Hadebe, Frank Brombacher, Gordon D Brown
Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is poorly understood, but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens. Fungal-derived allergens represent a major contributing factor in the initiation, persistence, exacerbation, and severity of allergic asthma. C-type lectin like receptors, such as dectin-1, dectin-2, DC-specific intercellular adhesion molecule 3-grabbing nonintegrin, and mannose receptor, recognize many fungal-derived allergens and other structurally similar allergens derived from house dust mites (HDM)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29668708/dectin-1-2-induced-autocrine-pge2-signaling-licenses-dendritic-cells-to-prime-th2-responses
#16
Maria M M Kaisar, Manuel Ritter, Carlos Del Fresno, Hulda S Jónasdóttir, Alwin J van der Ham, Leonard R Pelgrom, Gabriele Schramm, Laura E Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive potent Th2 responses, triggers DCs to produce prostaglandin E2 (PGE2), which subsequently-in an autocrine manner-induces OX40 ligand (OX40L) expression to license these DCs to drive Th2 responses. Mechanistically, SEA was found to promote PGE2 synthesis through Dectin-1 and Dectin-2, and via a downstream signaling cascade involving spleen tyrosine kinase (Syk), extracellular signal-regulated kinase (ERK), cytosolic phospholipase A2 (cPLA2), and cyclooxygenase 1 and 2 (COX-1 and COX-2)...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29666621/the-role-of-aire-in-the-immunity-against-candida-albicans-in-a-model-of-human-macrophages
#17
Jose Antonio Tavares de Albuquerque, Pinaki Prosad Banerjee, Angela Castoldi, Royce Ma, Nuria Bengala Zurro, Leandro Hideki Ynoue, Christina Arslanian, Marina Uchoa Wall Barbosa-Carvalho, Joya Emilie de Menezes Correia-Deur, Fernanda Guimarães Weiler, Magnus Regios Dias-da-Silva, Marise Lazaretti-Castro, Luis Alberto Pedroza, Niels Olsen Saraiva Câmara, Emily Mace, Jordan Scott Orange, Antonio Condino-Neto
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene ( AIRE ). Patients with AIRE mutations are susceptible to Candida albicans infection and present with autoimmune disorders. We previously demonstrated that cytoplasmic AIRE regulates the Syk-dependent Dectin-1 pathway. In this study, we further evaluated direct contact with fungal elements, synapse formation, and the response of macrophage-like THP-1 cells to C...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29661910/myeloid-cell-deficiency-of-p38%C3%AE-p38%C3%AE-protects-against-candidiasis-and-regulates-antifungal-immunity
#18
Dayanira Alsina-Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González-Romero, Ester Díaz-Mora, Ana Risco, Miguel A Martín-Serrano, Carlos Del Fresno, Jorge Dominguez-Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz-Ezquerro, Ana Cuenda
Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate immune response to C. albicans We describe a new TAK1-TPL2-MKK1-ERK1/2 pathway in macrophages, which is activated by Dectin-1 engagement and positively regulated by p38γ/p38δ. In mice, p38γ/p38δ deficiency protects against C...
May 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29648784/design-of-mannose-functionalized-curdlan-nanoparticles-for-macrophage-targeted-sirna-delivery
#19
Tsogzolmaa Ganbold, Huricha Baigude
6-Amino-6-deoxy-curdlan is a promising nucleic acid carrier that efficiently delivers plasmid DNA as well as short interfering RNA (siRNA) to various cell lines. The highly reactive C6-NH2 groups of 6-amino-6-deoxy-curdlan prompt conjugation of various side groups including tissue-targeting ligands to enhance cell-type-specific nucleic acid delivery to specific cell lines. Herein, to test the primary-cell-targeting efficiency of the curdlan derivative, we chemically conjugated a macrophage-targeting ligand, mannose, to 6-amino-6-deoxy-curdlan...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29643192/characterizing-the-mechanisms-of-nonopsonic-uptake-of-cryptococci-by-macrophages
#20
Jenson Lim, Christopher J Coates, Paula I Seoane, Mariam Garelnabi, Leanne M Taylor-Smith, Pauline Monteith, Camille L Macleod, Claire J Escaron, Gordon D Brown, Rebecca A Hall, Robin C May
The pathogenic fungus Cryptococcus enters the human host via inhalation into the lung and is able to reside in a niche environment that is serum- (opsonin) limiting. Little is known about the mechanism by which nonopsonic phagocytosis occurs via phagocytes in such situations. Using a combination of soluble inhibitors of phagocytic receptors and macrophages derived from knockout mice and human volunteers, we show that uptake of nonopsonized Cryptococcus neoformans and C. gattii via the mannose receptor is dependent on macrophage activation by cytokines...
May 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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