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https://www.readbyqxmd.com/read/29776717/m2-macrophages-promote-wound-induced-hair-neogenesis
#1
Akira Kasuya, Taisuke Ito, Yoshiki Tokura
BACKGROUND: De novo hair regeneration occurs in scars of normal adult mice. This interesting phenomenon is termed as wound-induced hair neogenesis (WIHN). We hypothesized that M2 macrophages are crucially involved in WIHN. OBJECTIVE: To clarify the contribution of M2 macrophages to WIHN. METHOD: We established a mouse model of WIHN. A full thickness skin excision was implemented on the back of C57BL/6 (B6) mice. Newly developing hair follicles were detected by a whole-mount assay...
May 12, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29770354/3d-co-culture-system-of-tumor-associated-macrophages-and-ovarian-cancer-cells
#2
Lingli Long, Mingzhu Yin, Wang Min
Ovarian cancer is fairly unique in that ovarian carcinoma cells can detach and spread directly through peritoneal cavity. It has been unclear, however, how detached cancer cells survive in the peritoneum and form spheroid structure. We have recently reported that there is a strong correlation between Tumor-associated macrophages (TAMs)-associated spheroid and clinical pathology of ovarian cancer, and that TAMs promote spheroid formation and tumor growth at early stages of transcoelomic metastasis in orthotopic mouse models...
April 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29769604/macrophage-cytokines-enhance-cell-proliferation-of-normal-prostate-epithelial-cells-through-activation-of-erk-and-akt
#3
Tu Dang, Geou-Yarh Liou
Macrophage infiltrations (inflammation) are associated with prostate disorders such as prostatitis, prostatic hyperplasia and prostate cancer. All prostate disorders have elevated cell proliferation, and are initiated from normal prostate epithelial cells. To date, the mechanism of how macrophages regulate normal prostate epithelial cell proliferation remains largely unknown. Using a 3D co-culture system, we here show that Raw 264.7 macrophages increased cell proliferation of normal prostate epithelial PZ-HPV-7 cells...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765984/jazf1-inhibits-adipose-tissue-macrophages-and-adipose-tissue-inflammation-in-diet-induced-diabetic-mice
#4
Fanping Meng, Yao Lin, Min Yang, Minyan Li, Gangyi Yang, Po Hao, Ling Li
Background: Juxtaposed with another zinc finger gene 1 (JAZF1) affects gluconeogenesis, insulin sensitivity, lipid metabolism, and inflammation, but its exact role in chronic inflammation remains unclear. This study aimed to examine JAZF1 overexpression in vivo on adipose tissue macrophages (ATMs). Methods: Mouse models of high-fat diet- (HFD-) induced insulin resistance were induced using C57BL/6J and JAZF1-overexpressing (JAZF1-OX) mice. The mice were randomized (8-10/group) to C57BL/6J mice fed regular diet (RD) (NC group), C57BL/6J mice fed HFD (HF group), JAZF1-OX mice fed RD (NJ group), and JAZF1-OX mice fed HFD (HJ group)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29764475/a-potential-gliovascular-mechanism-for-microglial-activation-differential-phenotypic-switching-of-microglia-by-endothelium-versus-astrocytes
#5
Changhong Xing, Wenlu Li, Wenjun Deng, MingMing Ning, Eng H Lo
BACKGROUND: Activation of microglia can result in phenotypic and functional diversity. However, the pathways that trigger different states of microglial activation remain to be fully understood. Here, we hypothesized that after injury, astrocytes and endothelium may contribute to a gliovascular switch for microglial activation. METHODS: Astrocytes or cerebral endothelial cells were subjected to oxygen glucose deprivation, then conditioned media were transferred to microglia...
May 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29761388/isolation-and-identification-of-interstitial-macrophages-from-the-lungs-using-different-digestion-enzymes-and-staining-strategies
#6
Shaikh M Atif, Sophie L Gibbings, Claudia V Jakubzick
Interstitial macrophages (IMs) are present in multiple organs. Although there is limited knowledge of the unique functional role IM subtypes play, macrophages, in general, are known for their contribution in homeostatic tissue maintenance and inflammation such as clearing pathogens and debris and secreting inflammatory mediators and growth factors. IM subtypes have been identified in the heart, skin, and gut, and more recently we identified three distinct IMs in the lung. IMs express on their surface high levels of MerTK, CD64, and CD11b, with differences in CD11c, CD206, and MHC II expression, and referred to the three pulmonary IM subtypes as IM1 (CD11clo CD206+ MHCIIlo ), IM2 (CD11clo CD206+ MHCIIhi ), and IM3 (CD11chi CD206lo MHCIIhi )...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29753749/quercetin-ameliorate-kidney-injury-and-fibrosis-by-modulating-m1-m2-macrophage-polarization
#7
Hong Lu, Lianfeng Wu, Leping Liu, Qingqing Ruan, Xing Zhang, Weilong Hong, Shijia Wu, Guihua Jin, Yongheng Bai
Interstitial inflammation is the main pathological feature in kidneys following injury, and the polarization of macrophages is involved in the process of inflammatory injury. Previous studies have shown that quercetin has a renal anti-inflammatory activity, but the potential molecular mechanism remains unknown. In obstructive kidneys, administration of quercetin inhibited tubulointerstitial injury and reduced the synthesis and release of inflammatory factors. Further study revealed that quercetin inhibited the infiltration of CD68+ macrophages in renal interstitium...
May 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29750307/exosomal-malat1-derived-from-oxidized-low-density-lipoprotein-treated-endothelial-cells-promotes-m2-macrophage-polarization
#8
Chaoyang Huang, Jie Han, Yutao Wu, Shan Li, Qiwen Wang, Wenjuan Lin, Jianhua Zhu
Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous cardiovascular diseases. Following activation by oxLDL, monocytes adhere to endothelial cells, migrate into the subendothelial spaces and then undergo differentiation into macrophages, which subsequently induces the formation of atherosclerotic lesions. However, the mechanisms underlying the activation of macrophage differentiation by oxLDL-treated endothelial cells remain unclear...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749104/soluble-fibrinogen-like-protein-2-ameliorates-acute-rejection-of-liver-transplantation-in-rat-via-inducing-kupffer-cells-m2-polarization
#9
Guangrui Pan, Zhengfei Zhao, Chengyong Tang, Liuyue Ding, Zhongtang Li, Daofeng Zheng, Liang Zong, Zhongjun Wu
Soluble fibrinogen-like protein 2 (sFGL2) could ameliorate acute rejection (AR) in rat cardiac transplantation. However, the role of sFGL2 in AR of liver transplantation has not been addressed. In this study, we found that FGL2 was upregulated in rat orthotropic liver transplantation (OLT) models of tolerance and positive correlation with the frequency of M2 Kupffer cells (KCs). Gain-of-function experiments in vitro showed that sFGL2 promoted the secretion of anti-inflammatory cytokines (IL-10, TGF-β) and the expression of CD206, and inhibited the activities of STAT1 and NF-κB signaling pathway...
May 10, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29745990/an-il-10-dominant-polarization-of-monocytes-is-a-feature-of-indian-visceral-leishmaniasis
#10
Susmita Roy, Debanjan Mukhopadhyay, Shibabrata Mukherjee, Srija Moulik, Soumyadip Chatterji, Nayan Brahme, Netai Pramanik, Rama P Goswami, Bibhuti Saha, Mitali Chatterjee
BACKGROUND: Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL) deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains as to whether they are deactivated or alternatively activated. METHODS AND RESULTS: The significantly raised plasma levels of IL-4/IL-13 and IL-10 in VL patients suggested a microenvironment conducive for alternative activation of monocytes/macrophages...
May 10, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29740932/antagonizing-peroxisome-proliferator-activated-receptor-%C3%AE-facilitates-m1-to-m2-shift-of-microglia-by-enhancing-autophagy-via-the-lkb1-ampk-signaling-pathway
#11
Juan Ji, Teng-Fei Xue, Xu-Dong Guo, Jin Yang, Ruo-Bing Guo, Juan Wang, Ji-Ye Huang, Xiao-Jie Zhao, Xiu-Lan Sun
Microglia-mediated neuroinflammation plays a dual role in various brain diseases due to distinct microglial phenotypes, including deleterious M1 and neuroprotective M2. There is growing evidence that the peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone prevents lipopolysaccharide (LPS)-induced microglial activation. Here, we observed that antagonizing PPARγ promoted LPS-stimulated changes in polarization from the M1 to the M2 phenotype in primary microglia. PPARγ antagonist T0070907 increased the expression of M2 markers, including CD206, IL-4, IGF-1, TGF-β1, TGF-β2, TGF-β3, G-CSF, and GM-CSF, and reduced the expression of M1 markers, such as CD86, Cox-2, iNOS, IL-1β, IL-6, TNF-α, IFN-γ, and CCL2, thereby inhibiting NFκB-IKKβ activation...
May 8, 2018: Aging Cell
https://www.readbyqxmd.com/read/29737241/human-mesenchymal-stromal-cell-sheets-induce-macrophages-predominantly-to-an-anti-inflammatory-phenotype
#12
Panithi Sukho, Jan Willem Hesselink, Nicole Kops, Jolle Kirpensteijn, Femke Verseijnden, Yvonne Bastiaansen-Jenniskens
Tissue healing is a highly complex process involving a cascade of biochemical and cellular events. Excessive inflammation can impair the healing response. Previous in vitro studies have shown that mesenchymal stromal cells can modulate macrophage-induced inflammation and therefore are promising candidates for cell-based therapies aimed at promoting tissue repair. Recently, cell sheets were introduced as a new method of delivering stromal cells to the repair-site. The goal of the current study was to compare the effect of different types of stromal cell sheets on the inflammatory state of macrophages <i>in vitro</i>...
May 8, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29737200/human-peripheral-blood-mononuclear-cells-incubated-in-vasculogenic-conditioning-medium-dramatically-improve-ischemia-reperfusion-acute-kidney-injury-in-mice
#13
Takayasu Ohtake, Shuzo Kobayashi, Shimon Slavin, Yasuhiro Mochida, Kunihiro Ishioka, Hidekazu Moriya, Sumi Hidaka, Ryo Matsuura, Maki Sumida, Daisuke Katagiri, Eisei Noiri, Kayoko Okada, Hiroshi Mizuno, Rica Tanaka
Acute kidney injury (AKI) is a major clinical problem that still has no established treatment. We investigated the efficacy of cultured human peripheral blood mononuclear cells (PBMNCs) for AKI. Ischemia/reperfusion injury (IRI) was used to induce AKI in male nonobese diabetic (NOD/severe combined immunodeficiency) mice aged 7 to 8 wk. PBMNCs were isolated from healthy volunteers and were subjected to quality and quantity controlled (QQc) culture for 7 d in medium containing stem cell factor, thrombopoietin, Flt-3 ligand, vascular endothelial growth factor, and interleukin 6...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29736739/inflammatory-and-anti-inflammatory-responses-co-exist-inside-lung-granuloma-of-fatal-cases-of-coccidioidomycosis-a-pilot-report
#14
Heidi G Rodriguez-Ramirez, Adolfo Soto-Dominguez, Gloria M González, Oralia Barboza-Quintana, Mario C Salinas-Carmona, Luis A Ceceñas-Falcon, Roberto Montes-de-Oca-Luna, Alma Y Arce-Mendoza, Adrian G Rosas-Taraco
Coccidioidomycosis is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii. These fungi are endemic in the southern USA and northern Mexico. Immunocompromised patients are susceptible to develop severe forms of this fungal infection. Cytokines play an important role in controlling the fungal infection, but little is known about the predominant immunological environment in human lung tissue from fatal cases. Our aim was to analyze the pro-inflammatory and anti-inflammatory cytokines and monocyte/macrophages markers (CD14 and CD206) in the granulomas of six fatal cases of coccidioidomycosis...
May 7, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29732570/cd206-positive-myeloid-cells-bind-galectin-9-and-promote-a-tumor-supportive-microenvironment
#15
Elizabeth Ann L Enninga, Kyriakos Chatzopoulos, John T Butterfield, Shari L Sutor, Alexey A Leontovich, Wendy K Nevala, Thomas J Flotte, Svetomir N Markovic
In patients with metastatic melanoma, high blood levels of galectin-9 are correlated with worse overall survival and a bias towards a Th2 inflammatory state supportive of tumor growth. Although galectin-9 signaling through TIM3 on T cells has been described, less is known about the interaction of galectin-9 with macrophages. We aimed to determine whether galectin-9 is a binding partner of CD206 on macrophages and whether the result of this interaction is tumor-supportive. It was determined that incubation of CD68+ macrophages with galectin-9 or anti-CD206 blocked target binding and that both CD206 and galectin-9 were detected by immunoprecipitation of cell lysates...
May 7, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29731774/b7-h1-expression-is-required-for-human-endometrial-regenerative-cells-in-the-prevention-of-transplant-vasculopathy-in-mice
#16
Kui Ye, Xu Lan, Grace Wang, Baoren Zhang, Xiaoxi Xu, Xiang Li, Yiming Zhao, Hao Wang
Vasculopathy is one of the primary pathological changes in chronic rejection of vascularized allograft transplantation. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells with immunosuppressive effect. B7-H1 is a negative costimulator that mediates active immune suppression. The aim of this study was to investigate the requirement of B7-H1 in the immunoregulation of ERCs in preventing transplant vasculopathy of aorta allografts. The results showed that B7-H1 expression on ERCs was upregulated by IFN- γ in a dose-dependent manner and it was required for ERCs to inhibit the proliferation of peripheral blood mononuclear cells (PBMCs) in vitro ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29730267/imatinib-prevents-lung-cancer-metastasis-by-inhibiting-m2-like-polarization-of-macrophages
#17
Zhangting Yao, Jieqiong Zhang, Bo Zhang, Guikai Liang, Xi Chen, Fengqi Yao, Xiaqing Xu, Honghai Wu, Qiaojun He, Ling Ding, Bo Yang
Although M2-like tumor-associated macrophages (TAMs) have been considered as a vital therapeutic target in cancer therapy due to their role in promoting tumor progression and metastasis, very few compounds have been identified to inhibit M2-like polarization of TAMs. Here, we showed that Imatinib significantly prevented macrophage M2-like polarization induced by IL-13 or IL-4 in vitro, as illustrated by reduced expression of cell surface marker CD206 and M2-like genes, including Arg1, Mgl2, Mrc1, CDH1, and CCL2...
May 3, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29726984/immune-cell-census-in-murine-atherosclerosis-cytometry-by-time-of-flight-illuminates-vascular-myeloid-cell-diversity
#18
Jennifer E Cole, Inhye Park, David Ahern, Christina Kassiteridi, Dina Danso Abeam, Michael Goddard, Patricia Green, Pasquale Maffia, Claudia Monaco
Aims: Atherosclerosis is characterised by the abundant infiltration of myeloid cells starting at early stages of disease. Myeloid cells are key players in vascular immunity during atherogenesis. However, the subsets of vascular myeloid cells have eluded resolution due to shared marker expression and atypical heterogeneity in vascular tissues. We applied the high-dimensionality of mass cytometry to the study of myeloid cell subsets in atherosclerosis. Methods and Results: Apolipoprotein E-deficient (ApoE-/-) mice were fed a chow or a high fat (western) diet for 12 weeks...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29697136/sphk2-protein-expression-ki-67-index-and-infiltration-of-tumor-associated-macrophages-tams-in-human-glioma
#19
J Liu, Q Zhou, C P Wu, Y W Xu, W L Liu, H F Zhao, W P Li
INTRODUCTION: Sphingosine kinases (SPHKs), the Ki-67 index and tumor-associated macrophages (TAMs) are associated with diverse human malignancies, including glioma. SPHK2, a subtype of SPHKs, has not been assessed in glioma or correlated with the Ki-67 index or TAM infiltration. We tested the hypothesis that expression of SPHK2 correlates with the Ki-67 index and TAM infiltration in patients with glioma. MATERIALS AND METHOD: Western blot analysis was performed on protein lysates prepared from human astrocyte (HA) and glioma cell lines...
April 26, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29682605/dual-affinity-heparin-based-hydrogels-achieve-pro-regenerative-immunomodulation-and-microvascular-remodeling
#20
Molly E Ogle, Jack R Krieger, Liane E Tellier, Jennifer McFaline-Figueroa, Johnna S Temenoff, Edward A Botchwey
The immune response to biomaterial implants critically regulates functional outcomes such as vascularization, transplant integration/survival, and fibrosis. To create "immunologically smart" materials, the host-material response may be engineered to optimize the recruitment of pro-regenerative leukocyte subsets which mature into corresponding wound-healing macrophages. We have recently identified a unique feature of pro-regenerative Ly6Clow monocytes that is a higher expression of both the bioactive lipid receptor sphingosine-1-phosphate receptor 3 (S1PR3) and the stromal derived factor-1α (SDF-1α) receptor CXCR4...
April 9, 2018: ACS Biomaterials Science & Engineering
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