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https://www.readbyqxmd.com/read/29671117/lewis-antigen-containing-icam-2-3-on-jurkat-leukemia-cells-interact-with-dc-sign-to-regulate-dc-functions
#1
Xin Jin, Qingpan Bu, Yingying Zou, Yunpeng Feng, Min Wei
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is an important C-type lectin and plays a critical role in the recognition of pathogens and self-antigens. It has recently been shown that DC-SIGN directly interacts with acute T lymphoblastic leukemia cells. However, the mechanism regulating DC-SIGN-dependent DC association as well as related functions is still elusive. Here we showed that DC-SIGN preferentially bound to a set of malignant T lymphocytes, including Jurkat, CCRF-HSB2 and CCRF-CEM...
April 18, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29666116/critical-influences-on-the-pathogenesis-of-follicular-lymphoma
#2
Ralf Küppers, Freda K Stevenson
The development of follicular lymphoma (FL) from a founder B cell with an upregulation of BCL2, via the t(14;18) translocation, to a proliferating clone, poised to undergo further transformation to an aggressive lymphoma, illustrates the opportunistic Darwinian process of tumorigenesis. Protection against apoptosis allows an innocent cell to persist and divide, with dangerous accumulation of further mutational changes, commonly involving inactivation of chromatin-modifying genes. But this is not all. FL cells reflect normal B cells in relying on expression of surface Ig...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29662482/targeting-mycobacterium-tuberculosis-antigens-to-dendritic-cells-via-the-dc-specific-icam3-grabbing-nonintegrin-receptor-induces-strong-t-helper-1-immune-responses
#3
Lis Noelia Velasquez, Philipp Stüve, Maria Virginia Gentilini, Maxine Swallow, Judith Bartel, Nils Yngve Lycke, Daniel Barkan, Mariana Martina, Hugo D Lujan, Hakan Kalay, Yvette van Kooyk, Tim D Sparwasser, Luciana Berod
Tuberculosis remains a major global health problem and efforts to develop a more effective vaccine have been unsuccessful so far. Targeting antigens (Ags) to dendritic cells (DCs) in vivo has emerged as a new promising vaccine strategy. In this approach, Ags are delivered directly to DCs via antibodies that bind to endocytic cell-surface receptors. Here, we explored DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) targeting as a potential vaccine against tuberculosis. For this, we made use of the hSIGN mouse model that expresses human DC-SIGN under the control of the murine CD11c promoter...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29655658/elucidating-the-mechanisms-of-action-of-saponin-derived-adjuvants
#4
REVIEW
Dante J Marciani
Numerous triterpenoid saponins are adjuvants that modify the activities of T cells and antigen-presenting cells, like dendritic cells (DCs). Saponins can induce either proinflammatory Th1/Th2 or sole anti-inflammatory Th2 immunities. Structure-activity relationships (SARs) have shown that imine-forming carbonyl groups are needed for T cell activation leading to induction of Th1/Th2 immunities. While saponins having different triterpenoid aglycons and oligosaccharide chains can activate DCs to induce Th1/Th2 immunoresponses, fucopyranosyl residues from their oligosaccharides by binding to the DC-SIGN receptor can bias DCs toward a sole Th2 immunity...
April 11, 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29648611/fine-mapping-the-interaction-between-dc-sign-and-the-cytomegalovirus-envelope-glycoprotein-b
#5
Coraline Chéneau, Flora Coulon, Vanessa Porkolab, Franck Fieschi, Stéphanie Laurant, Diane Razanajaona-Doll, Jean-Jacques Pin, Eva Maria Borst, Martin Messerle, Céline Bressollette-Bodin, Franck Halary
Human cytomegalovirus (HCMV) is a leading cause of virally-induced congenital disorders and morbidities in immunocompromised individuals, i.e. transplant, cancer or AIDS patients. HCMV infects virtually all cell types through the envelope glycoprotein complex gH/gL/gO with our without a contribution of the pentameric gH/gL/pUL128L. Together with gH/gL, the HCMV envelope glycoprotein B (gB) contributes to the viral fusion machinery. We previously showed that gB is a ligand for the C-type lectin Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin (DC-SIGN) contributing to HCMV attachment to and infection of DC-SIGN expressing cells...
April 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29643243/inefficient-hiv-1-trans-infection-of-cd4-t-cells-by-macrophages-from-hiv-1-nonprogressors-is-associated-with-altered-membrane-cholesterol-and-dc-sign
#6
Diana C DeLucia, Charles R Rinaldo, Giovanna Rappocciolo
Professional antigen presenting cells (APC: myeloid dendritic cells (DC) and macrophages (MΦ); B lymphocytes) mediate highly efficient HIV-1 infection of CD4+ T cells, termed trans infection, that could contribute to HIV-1 pathogenesis. We have previously shown that lower cholesterol content in DC and B lymphocytes is associated with a lack of HIV-1 trans infection in HIV-1 infected nonprogressors (NP). Here we assessed whether HIV-1 trans infection mediated by another major APC, MΦ, is deficient in NP due to altered cholesterol metabolism...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29511377/differences-in-c-type-lectin-receptors-and-their-adaptor-molecules-in-the-peritoneal-fluid-of-patients-with-endometriosis-and-gynecologic-cancers
#7
Seung Geun Yeo, Yong Sung Won, Sang Hoon Kim, Dong Choon Park
Endometriosis, although not malignant, has clinically demonstrated properties of invasiveness and metastasis. The pathogenesis of endometriosis, however, has not yet been elucidated. The immunological differences between endometriosis and malignant gynecologic tumors were analyzed by assessing C-type lectin receptors, which are associated with innate immunity, and immunoglobulin secretion, which is associated with B cell adaptive immunity, in the peritoneal fluid of these patients. Peritoneal fluid samples were obtained from 42 patients with benign masses (control group), 38 with endometriosis, and 43 with gynecologic (ovarian, uterine, and cervical) cancers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29505573/clonorchis-sinensis-adult-derived-proteins-elicit-th2-immune-responses-by-regulating-dendritic-cells-via-mannose-receptor
#8
Lu Zhao, Mengchen Shi, Lina Zhou, Hengchang Sun, Xiaona Zhang, Lei He, Zeli Tang, Caiqin Wang, Yinjuan Wu, Tingjin Chen, Mei Shang, Xinyi Zhou, Zhipeng Lin, Xuerong Li, Xinbing Yu, Yan Huang
BACKGROUND: Clonorchis sinensis (C. sinensis) is the most widespread human liver fluke in East Asia including China and Korea. Clonorchiasis as a neglected tropical zoonosis, leads to serious economic and public health burden in China. There are considerable evidences for an etiological relation between chronic clonorchiasis and liver fibrosis in human beings. Liver fibrosis is a highly conserved and over-protected response to hepatic tissue injury. Immune cells including CD4+ T cell as well as dendritic cell (DC), and pro-fibrogenic cytokines like interleukin 4 (IL-4), IL-13 have been identified as vital manipulators in liver fibrogenesis...
March 5, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29482715/expression-of-c-type-lectin-receptors-and-toll-like-receptors-in-decidua-of-patients-with-unexplained-recurrent-spontaneous-abortion
#9
Liang Xu, Tian Qiu, Yudong Wang, Yan Chen, Weiwei Cheng
In the present study, the mechanisms underlying the pathogenesis of unexplained recurrent spontaneous abortion (URSA) were explored. The protein and mRNA expression of two C-type lectin-like receptors (CLRs), namely dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and mannose receptor (MR), and two Toll-like receptors (TLRs), namely TLR2 and TLR4, in the decidua and dendritic cells (DCs) was compared between URSA patients and normal controls. URSA patients had significantly lower protein and mRNA expression of DC-SIGN and significantly higher expression of TLR2 and TLR4 in decidual tissues compared with normal controls...
August 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29463753/signal-peptide-of-hiv-envelope-protein-impacts-glycosylation-and-antigenicity-of-gp120
#10
Jason Yolitz, Catherine Schwing, Julia Chang, Donald Van Ryk, Fatima Nawaz, Danlan Wei, Claudia Cicala, James Arthos, Anthony S Fauci
The HIV-1 envelope protein (Env) of early-replicating viruses encodes several distinct transmission signatures. One such signature involves a reduced number of potential N-linked glycosylation sites (PNGs). This transmission signature underscores the importance of posttranslational modifications in the fitness of early-replicating isolates. An additional signature in Env involves the overrepresentation of basic amino acid residues at a specific position in the Env signal peptide (SP). In this report, we investigated the potential impact of this SP signature on gp120 glycosylation and antigenicity...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29455681/human-dendritic-cell-sequestration-onto-the-necator-americanus-larval-sheath-during-ex-sheathing-a-possible-mechanism-for-immune-privilege
#11
A Hassan, D I Pritchard, A M Ghaemmaghami
Despite the profound health implications of Necator americanus infection in humans, many aspects of its interaction with the host immune system are poorly understood. Here we investigated the early events at the interface of N. americanus larvae (L3) and human dendritic cells (DCs). Our data show that co-culturing DCs and the larvae trigger ex-sheathing of hookworms rapidly where a majority of DCs are sequestered onto the larval sheath allowing the ex-sheathed larvae to migrate away unchallenged. Intriguingly, DCs show negligible interaction with the ex-sheathed larvae, alluding to differences between the surface chemistry of the larva and its sheath...
February 19, 2018: Parasitology
https://www.readbyqxmd.com/read/29428526/new-branched-amino-acids-for-high-affinity-dendrimeric-dc-sign-ligands
#12
Laurent Cattiaux, Vanessa Porkolab, Franck Fieschi, Jean-Maurice Mallet
A branched amino acid was synthesized from methyl glucopyranoside; this amino acid presents three amino groups protected by Fmoc and one acid group and can be used in classic peptide synthesis. In parallel, similar azido terminated blocks were synthesized. Successive coupling reaction and deprotection afforded dendrimers with up to 27 azido functional groups. As an example of application, d-mannose and l-fucose residues were linked through CuAAC coupling and resulting glycodendrimers were evaluated in their interaction with DC-SIGN using SPR competition assay...
December 26, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29388006/glycan-recognition-by-human-blood-mononuclear-cells-with-an-emphasis-on-dendritic-cells
#13
Eugenia M Rapoport, Sergey V Khaidukov, Andrey M Gaponov, Galina V Pazynina, Svetlana V Tsygankova, Ivan M Ryzhov, Ivan M Belyanchikov, Panagiota Milona, Nicolai V Bovin, Kenneth C McCullough
Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. To this end, we explored recognition of DCs lectins by glycans. For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes...
January 31, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29386115/cd209a-synergizes-with-dectin-2-and-mincle-to-drive-severe-th17-cell-mediated-schistosome-egg-induced-immunopathology
#14
Parisa Kalantari, Yoelkys Morales, Emily A Miller, Luis D Jaramillo, Holly E Ponichtera, Marcel A Wuethrich, Cheolho Cheong, Maria C Seminario, Joanne M Russo, Stephen C Bunnell, Miguel J Stadecker
The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL-23 produced by dendritic cells that express CD209a (SIGNR5), a C-type lectin receptor (CLR) related to human DC-SIGN. Here, we show that CD209a-deficient CBA mice display decreased Th17 responses and are protected from severe immunopathology. In vitro, CD209a augments the egg-induced IL-1β and IL-23 production initiated by the related CLRs Dectin-2 and Mincle...
January 30, 2018: Cell Reports
https://www.readbyqxmd.com/read/29370305/alterations-of-hiv-1-envelope-phenotype-and-antibody-mediated-neutralization-by-signal-peptide-mutations
#15
Chitra Upadhyay, Roya Feyznezhad, Weiming Yang, Hui Zhang, Susan Zolla-Pazner, Catarina E Hioe
HIV-1 envelope glycoprotein (Env) mediates virus attachment and entry into the host cells. Like other membrane-bound and secreted proteins, HIV-1 Env contains at its N terminus a signal peptide (SP) that directs the nascent Env to the endoplasmic reticulum (ER) where Env synthesis and post-translational modifications take place. SP is cleaved during Env biosynthesis but potentially influences the phenotypic traits of the Env protein. The Env SP sequences of HIV-1 isolates display high sequence variability, and the significance of such variability is unclear...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29362230/contrasting-function-of-structured-n-terminal-and-unstructured-c-terminal-segments-of-mycobacterium-tuberculosis-ppe37-protein
#16
Javeed Ahmad, Aisha Farhana, Rita Pancsa, Simran Kaur Arora, Alagiri Srinivasan, Anil Kumar Tyagi, Madan Mohan Babu, Nasreen Zafar Ehtesham, Seyed Ehtesham Hasnain
Pathogens frequently employ eukaryotic linear motif (ELM)-rich intrinsically disordered proteins (IDPs) to perturb and hijack host cell networks for a productive infection. Mycobacterium tuberculosis has a relatively high percentage of IDPs in its proteome, the significance of which is not known. The Mycobacterium -specific PE-PPE protein family has several members with unusually high levels of structural disorder and disorder-promoting Ala/Gly residues. PPE37 protein, a member of this family, carries an N-terminal PPE domain capable of iron binding, two transmembrane domains, and a disordered C-terminal segment harboring ELMs and a eukaryotic nuclear localization signal (NLS)...
January 23, 2018: MBio
https://www.readbyqxmd.com/read/29306433/insights-into-glucan-polysaccharide-recognition-using-glucooligosaccharide-microarrays-with-oxime-linked-neoglycolipid-probes
#17
Yan Liu, Angelina S Palma, Ten Feizi, Wengang Chai
Glucans are polysaccharides of increasing biomedical interest because of their involvement in mechanisms of pathogen recognition, modulation of the immune system and anticancer, and health-promoting activities. Most of these biological activities occur through specific interactions with glucan-recognizing proteins. However, detailed molecular studies of glucan recognition remain a challenge mainly due to the inherent sequence heterogeneity and polydispersity of glucan polysaccharides, and associated difficulties in their purification and sequence characterization...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29288676/transcriptomic-profiles-of-post-smolt-atlantic-salmon-challenged-with-piscirickettsia-salmonis-reveal-a-strategy-to-evade-the-adaptive-immune-response-and-modify-cell-autonomous-immunity
#18
Marco Rozas-Serri, Andrea Peña, Lucerina Maldonado
Piscirickettsiosis is the main bacterial disease affecting the Chilean salmon farming industry and is responsible for high economic losses. The development of effective strategies to control piscirickettsiosis has been limited in part by insufficient knowledge of the host response. The aim of this study was to use RNA sequencing to describe the transcriptional profiles of the responses of post-smolt Atlantic salmon infected with LF-89-like or EM-90-like Piscirickettsia salmonis. Enrichment and pathway analyses of the differentially expressed genes revealed several central signatures following infection, including positive regulation of DC-SIGN and TLR5 signalling, which converged at the NF-κB level to modulate the pro-inflammatory cytokine response, particularly in the PS-EM-90-infected fish...
April 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29275858/engineered-sialylation-of-pathogenic-antibodies-in-vivo-attenuates-autoimmune-disease
#19
Jose D Pagan, Maya Kitaoka, Robert M Anthony
Self-reactive IgGs contribute to the pathology of autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. Paradoxically, IgGs are used to treat inflammatory diseases in the form of high-dose intravenous immunoglobulin (IVIG). Distinct glycoforms on the IgG crystallizable fragment (Fc) dictate these divergent functions. IgG anti-inflammatory activity is attributed to sialylation of the Fc glycan. We therefore sought to convert endogenous IgG to anti-inflammatory mediators in vivo by engineering solubilized glycosyltransferases that attach galactose or sialic acid...
January 25, 2018: Cell
https://www.readbyqxmd.com/read/29175084/manipulating-human-dendritic-cell-phenotype-and-function-with-targeted-porous-silicon-nanoparticles
#20
Sebastian O Stead, Steven J P McInnes, Svjetlana Kireta, Peter D Rose, Shilpanjali Jesudason, Darling Rojas-Canales, David Warther, Frédérique Cunin, Jean-Olivier Durand, Christopher J Drogemuller, Robert P Carroll, P Toby Coates, Nicolas H Voelcker
Dendritic cells (DC) are the most potent antigen-presenting cells and are fundamental for the establishment of transplant tolerance. The Dendritic Cell-Specific Intracellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN; CD209) receptor provides a target for dendritic cell therapy. Biodegradable and high-surface area porous silicon (pSi) nanoparticles displaying anti-DC-SIGN antibodies and loaded with the immunosuppressant rapamycin (Sirolimus) serve as a fit-for-purpose platform to target and modify DC...
February 2018: Biomaterials
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