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https://www.readbyqxmd.com/read/27919079/receptor-usage-dictates-hiv-1-restriction-by-human-trim5%C3%AE-in-dendritic-cell-subsets
#1
Carla M S Ribeiro, Ramin Sarrami-Forooshani, Laurentia C Setiawan, Esther M Zijlstra-Willems, John L van Hamme, Wikky Tigchelaar, Nicole N van der Wel, Neeltje A Kootstra, Sonja I Gringhuis, Teunis B H Geijtenbeek
The most prevalent route of HIV-1 infection is across mucosal tissues after sexual contact. Langerhans cells (LCs) belong to the subset of dendritic cells (DCs) that line the mucosal epithelia of vagina and foreskin and have the ability to sense and induce immunity to invading pathogens. Anatomical and functional characteristics make LCs one of the primary targets of HIV-1 infection. Notably, LCs form a protective barrier against HIV-1 infection and transmission. LCs restrict HIV-1 infection through the capture of HIV-1 by the C-type lectin receptor Langerin and subsequent internalization into Birbeck granules...
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27874116/understanding-carbohydrate-protein-interactions-using-homologous-supramolecular-chiral-ru-ii-glyconanoclusters
#2
Harikrishna Bavireddi, Raghavendra Vasudeva Murthy, Madhuri Gade, Sivakoti Sangabathuni, Preeti Madhukar Chaudhary, Catherine Alex, Bernd Lepenies, Raghavendra Kikkeri
Multivalent glycodendrimers make promising tools to tackle the basic and translational research in the field of carbohydrate-mediated interactions. Despite advances in glycodendrimers and glycopolymers, the multivalent probes available to date are still far from being ideal biological mimics. This work demonstrates the inherent chirality of glycodendrimers to be one of the promising factors to generate different spatial carbohydrate micro-environments to modulate specific carbohydrate-protein interactions. By exploiting the host-guest strategy, chiral Ru(ii) complexes (Δ and Λ) and mannose capped β-cyclodextrin (β-CD), we generated a library of homologous metallo-glycodendrimers (MGDs) with sizes of 50-70 nm...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27859859/oligomerization-domains-in-the-glycan-binding-receptors-dc-sign-and-dc-signr-sequence-variation-and-stability-differences
#3
Ália Dos Santos, Andreas Hadjivasiliou, Felipe Ossa, Novandy K Lim, Aylin Turgut, Maureen E Taylor, Kurt Drickamer
Human dendritic cell-specific intercellular adhesion molecule-1 grabbing nonintegrin, DC-SIGN, and the sinusoidal endothelial cell receptor DC-SIGNR or L-SIGN, are closely related sugar-binding receptors. DC-SIGN acts both as a pathogen-binding endocytic receptor and as a cell adhesion molecule, while DC-SIGNR has only the pathogen-binding function. In addition to differences in the sugar-binding properties of the carbohydrate-recognition domains in the two receptors, there are sequence differences in the adjacent neck domains, which are coiled-coil tetramerization domains comprised largely of 23-amino acid repeat units...
November 17, 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27832191/dengue-virus-infection-is-through-a-cooperative-interaction-between-a-mannose-receptor-and-clec5a-on-macrophage-as-a-multivalent-hetero-complex
#4
Yen-Lung Lo, Gunn-Guang Liou, Jia-Huei Lyu, Michael Hsiao, Tsui-Ling Hsu, Chi-Huey Wong
Dengue fever is a mosquito-borne viral pandemic disease that is widespread in the tropical and subtropical areas. Dengue virus uses human mannose-binding receptor (MR) and DC-SIGN on macrophages as primary receptors, and CLEC5A as signaling receptor to sense the dengue virus invasion and then to signal and stimulate macrophages to secrete cytokines. But the interplay between MR/DC-SIGN and CLEC5A is unknown. Here we demonstrate a plausible mechanism for the interaction, i.e. MR/DC-SIGN first attracts the virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction...
2016: PloS One
https://www.readbyqxmd.com/read/27808089/splenic-differentiation-and-emergence-of-ccr5-cxcl9-cxcl10-monocyte-derived-dendritic-cells-in-the-brain-during-cerebral-malaria
#5
Isabella C Hirako, Marco A Ataide, Lucas Faustino, Patricia A Assis, Elizabeth W Sorensen, Hisashi Ueta, Natalia M Araújo, Gustavo B Menezes, Andrew D Luster, Ricardo T Gazzinelli
Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b(+)F4/80(+)CD11c(+)MHCII(high)DC-SIGN(high)Ly6c(+) and express high levels of CCR5, CXCL9 and CXCL10 (CCR5(+)CXCL9/10(+) MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route...
November 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27805009/metformin-uniquely-prevents-thrombosis-by-inhibiting-platelet-activation-and-mtdna-release
#6
Guang Xin, Zeliang Wei, Chengjie Ji, Huajie Zheng, Jun Gu, Limei Ma, Wenfang Huang, Susan L Morris-Natschke, Jwu-Lai Yeh, Rui Zhang, Chaoyi Qin, Li Wen, Zhihua Xing, Yu Cao, Qing Xia, Yanrong Lu, Ke Li, Hai Niu, Kuo-Hsiung Lee, Wen Huang
Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce cardiovascular complications in diabetic patients. However, whether metformin can effectively prevent thrombosis and its potential mechanism of action is unknown. Here we show, metformin prevents both venous and arterial thrombosis with no significant prolonged bleeding time by inhibiting platelet activation and extracellular mitochondrial DNA (mtDNA) release...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792919/ppar-%C3%AE-agonist-pioglitazone-regulates-dendritic-cells-immunogenicity-mediated-by-dc-sign-via-the-mapk-and-nf-%C3%AE%C2%BAb-pathways
#7
Weiguo Zhu, Hui Yan, Shan Li, Wencheng Nie, Fangyan Fan, Jianhua Zhu
Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) is a dendritic cell-specific lectin which participates in dendritic cell (DC) trafficking, antigen uptake and DC-T cell interactions at the initiation of immune responses. This study investigated whether peroxisome proliferator-activated receptor-gamma (PPAR-γ) activation in human DCs regulates the immunogenicity of DCs mediated by DC-SIGN and exploited the possible molecular mechanisms, especially focused on the signaling pathways of mitogen-activated protein kinases (MAPK) and nuclear factor-κB (NF-κB)...
October 25, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27734954/pseudo-mannosylated-dc-sign-ligands-as-immunomodulants
#8
Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici
DC-SIGN, a C-type lectin mainly expressed by DCs, mediates antigen uptake and can induce specific immune responses, depending on the ligand involved. Owing to these properties, DC-SIGN is an attracting target for approaches aimed at tailoring the immune response towards specific immunologic outcomes. A multivalent DC-SIGN ligand (Polyman26), containing at its core a fluorescent "rod-like" spacer and able to inhibit DC-SIGN mediated HIV infection in nanomolar concentration, has been recently developed by our group...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27711121/identification-of-ompa-like-protein-of-tannerella-forsythia-as-an-o-linked-glycoprotein-and-its-binding-capability-to-lectins
#9
Toshi Horie, Megumi Inomata, Takeshi Into, Yoshiaki Hasegawa, Noriyuki Kitai, Fuminobu Yoshimura, Yukitaka Murakami
Bacterial glycoproteins are associated with physiological and pathogenic functions of bacteria. It remains unclear whether bacterial glycoproteins can bind to specific classes of lectins expressed on host cells. Tannerella forsythia is a gram-negative oral anaerobe that contributes to the development of periodontitis. In this study, we aimed to find lectin-binding glycoproteins in T. forsythia. We performed affinity chromatography of wheat germ agglutinin, which binds to N-acetylglucosamine (GlcNAc) and sialic acid (Sia), and identified OmpA-like protein as the glycoprotein that has the highest affinity...
2016: PloS One
https://www.readbyqxmd.com/read/27676269/nonhydrolyzable-c-disaccharides-a-new-class-of-dc-sign-ligands
#10
Benedetta Bertolotti, Beáta Oroszová, Ieva Sutkeviciute, Ladislav Kniežo, Franck Fieschi, Kamil Parkan, Zuzana Lovyová, Martina Kašáková, Jitka Moravcová
The discovery of effective ligands for DC-SIGN receptor is one of the most challenging concepts of antiviral drug design due to the importance of this C-type lectin in infection processes. DC-SIGN recognizes mannosylated and fucosylated oligosaccharides but glycosidic linkages are accessible to both chemical and enzymatic degradations. To avoid this problem, the synthesis of stable glycoside mimetics has attracted increasing attention. In this work we establish for the first time mono- and divalent C-glycosides based on d-manno and l-fuco configurations as prospective DC-SIGN ligands...
September 9, 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/27658394/functionally-aberrant-dendritic-cell-subsets-and-expression-of-dc-sign-differentiate-acute-from-chronic-hbv-infection
#11
Sukriti Sukriti, Nirupma Trehanpati, Manoj Kumar, Chandana Pande, Syed S Hissar, Shiv Kumar Sarin
BACKGROUND: Dendritic cells (DCs) promote pathogen recognition, uptake and presentation of antigen through DC-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and toll-like receptors (TLRs). AIMS AND OBJECTIVES: We aimed to study temporal changes in DCs, TLRs and DC-SIGN during acute viral hepatitis B (AVHB) infection and compare them to chronic (CHB) and to investigate the earliest time point of activated pathogen recognition receptors in hepatitis B viral infection...
September 22, 2016: Hepatology International
https://www.readbyqxmd.com/read/27643915/modulation-of-proinflammatory-cytokines-in-monocyte-derived-dendritic-cells-by-porcine-reproductive-and-respiratory-syndrome-virus-through-interaction-with-the-porcine-intercellular-adhesion-molecule-3-grabbing-nonintegrin
#12
Pablo E Piñeyro, Sakthivel Subramaniam, Scott P Kenney, C Lynn Heffron, Luis G Giménez-Lirola, Xiang-Jin Meng
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important global swine pathogen. PRRSV infects porcine dendritic cells (DCs), but the effects of the interactions with DCs are largely unknown. Current research focuses on the production and regulation of interferons and selected inflammatory cytokines in DCs, which may play key roles in immune modulation. In addition, PRRSV also downregulates swine leukocyte antigen class I (SLA-I), SLA-II, and CD80/86 costimulatory molecules in DCs...
December 2016: Viral Immunology
https://www.readbyqxmd.com/read/27641362/linear-biocompatible-glyco-polyamidoamines-as-dual-action-mode-virus-infection-inhibitors-with-potential-as-broad-spectrum-microbicides-for-sexually-transmitted-diseases
#13
Nicolò Mauro, Paolo Ferruti, Elisabetta Ranucci, Amedea Manfredi, Angela Berzi, Mario Clerici, Valeria Cagno, David Lembo, Alessandro Palmioli, Sara Sattin
The initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. Blocking the latter with high-affinity ligands may inhibit infection. DC-SIGN, a C-type lectin receptor expressed by immature dendritic cells and macrophages, mediates human immunodeficiency virus (HIV) infection by recognizing mannose clusters on the HIV-1 gp120 envelope glycoprotein. Mannosylated glycodendrimers act as HIV entry inhibitors thanks to their ability to block this receptor. Previously, an amphoteric, but prevailingly cationic polyamidoamine named AGMA1 proved effective as infection inhibitor for several heparan sulfate proteoglycan-dependent viruses, such as human papilloma virus HPV-16 and herpes simplex virus HSV-2...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27639309/glycome-complexity-of-human-seminal-plasma-high-molecular-mass-components-evaluation-of-the-contribution-of-acid-soluble-glycoproteins-mucins-and-extracellular-vesicles
#14
Bojana Milutinovic, Ninoslav Mitic, Jelena Roncevic, Sanja Goc, Miroslava Jankovic
This study was aimed at evaluation of the contribution of acid-soluble glycoproteins (ASG)/mucins and extracellular vesicles (EVs), yet unexplored components of human seminal plasma (hSP) to the complexity of its glycome. Gaining insight into the native presentation and distribution of glycans across hSP could help establish molecular environments supporting specific biological activities based on unique ligand capacities. Soluble and particulate fractions of hSP from healthy subjects were analyzed by gel filtration, electrophoresis, ion-exchange chromatography and a solid phase assay with immobilized charge-resolved glycospecies to test their reactivity with plant lectins, carbohydrate-binding antibodies and selected human lectins...
November 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27605665/hiv-1-gp120-glycoprotein-interacting-with-dendritic-cell-specific-intercellular-adhesion-molecule-3-grabbing-non-integrin-dc-sign-down-regulates-tight-junction-proteins-to-disrupt-the-blood-retinal-barrier-and-increase-its-permeability
#15
Yi-Wen Qian, Chuan Li, Ai-Ping Jiang, Shengfang Ge, Ping Gu, Xianqun Fan, Tai-Sheng Li, Xia Jin, Jian-Hua Wang, Zhi-Liang Wang
Approximately 70% of HIV-1 infected patients acquire ocular opportunistic infections and manifest eye disorders during the course of their illness. The mechanisms by which pathogens invade the ocular site, however, are unclear. Under normal circumstances, vascular endothelium and retinal pigment epithelium (RPE), which possess a well developed tight junction complex, form the blood-retinal barrier (BRB) to prevent pathogen invasion. We hypothesize that disruption of the BRB allows pathogen entry into ocular sites...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27599995/impact-of-apol1-polymorphism-and-il-1%C3%AE-priming-in-the-entry-and-persistence-of-hiv-1-in-human-podocytes
#16
Joanna Mikulak, Ferdinando Oriolo, Federica Portale, Paolo Tentorio, Xiqian Lan, Moin A Saleem, Karl Skorecki, Pravin C Singhal, Domenico Mavilio
BACKGROUND: Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-risk wild type (WT) G0 variant. However, the mechanistic contribution of the APOL1 allelic state to kidney injury in HIV-1 infection remains to be elucidated. RESULTS: Non-risk WT APOL1 is associated with lower intracellular levels of HIV-1 in conditionally immortalized human podocytes, while the over expression of G1 or G2 risk Vs significantly increases viral accumulation...
2016: Retrovirology
https://www.readbyqxmd.com/read/27579858/dendritic-cells-from-the-human-female-reproductive-tract-rapidly-capture-and-respond-to-hiv
#17
M Rodriguez-Garcia, Z Shen, F D Barr, A W Boesch, M E Ackerman, J C Kappes, C Ochsenbauer, C R Wira
Dendritic cells (DCs) throughout the female reproductive tract (FRT) were examined for phenotype, HIV capture ability and innate anti-HIV responses. Two main CD11c(+) DC subsets were identified: CD11b(+) and CD11b(low) DCs. CD11b(+)CD14(+) DCs were the most abundant throughout the tract. A majority of CD11c(+)CD14(+) cells corresponded to CD1c(+) myeloid DCs, whereas the rest lacked CD1c and CD163 expression (macrophage marker) and may represent monocyte-derived cells. In addition, we identified CD103(+) DCs, located exclusively in the endometrium, whereas DC-SIGN(+) DCs were broadly distributed throughout the FRT...
August 31, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27563159/compact-polyvalent-mannose-quantum-dots-as-sensitive-ratiometric-fret-probes-for-multivalent-protein-ligand-interactions
#18
Yuan Guo, Chadamas Sakonsinsiri, Inga Nehlmeier, Martin A Fascione, Haiyan Zhang, Weili Wang, Stefan Pöhlmann, W Bruce Turnbull, Dejian Zhou
A highly efficient cap-exchange approach for preparing compact, dense polyvalent mannose-capped quantum dots (QDs) has been developed. The resulting QDs have been successfully used to probe multivalent interactions of HIV/Ebola receptors DC-SIGN and DC-SIGNR (collectively termed as DC-SIGN/R) using a sensitive, ratiometric Förster resonance energy transfer (FRET) assay. The QD probes specifically bind DC-SIGN, but not its closely related receptor DC-SIGNR, which is further confirmed by its specific blocking of DC-SIGN engagement with the Ebola virus glycoprotein...
April 4, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27554817/human-cd40l-deficiency-dysregulates-the-macrophage-transcriptome-causing-functional-defects-that-are-improved-by-exogenous-ifn-%C3%AE
#19
Otavio Cabral-Marques, Rodrigo Nalio Ramos, Lena F Schimke, Taj Ali Khan, Eduardo Pinheiro Amaral, Caio César Barbosa Bomfim, Osvaldo Reis Junior, Tabata Takahashi França, Christina Arslanian, Joanna Darck Carola Correia Lima, Cristina Worm Weber, Janaíra Fernandes Ferreira, Fabiola Scancetti Tavares, Jing Sun, Maria Regina D Imperio Lima, Marília Seelaender, Vera Lucia Garcia Calich, José Alexandre Marzagão Barbuto, Beatriz Tavares Costa-Carvalho, Gabriela Riemekasten, Gisela Seminario, Liliana Bezrodnik, Luigi Notarangelo, Troy R Torgerson, Hans D Ochs, Antonio Condino-Neto
BACKGROUND: CD40 ligand (CD40L) deficiency predisposes to opportunistic infections, including those caused by fungi and intracellular bacteria. Studies of CD40L-deficient patients reveal the critical role of CD40L-CD40 interaction for the function of T-, B-, and dendritic cells. However, the consequences of CD40L deficiency on macrophage function remain to be investigated. OBJECTIVES: To determine the impact of CD40L absence on monocytes-derived macrophage (MDMs) responses...
August 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27554335/dc-sign-promotes-allergen-uptake-and-activation-of-dendritic-cells-in-patients-with-atopic-dermatitis
#20
Y Zhang, Y Luo, W Li, J Liu, M Chen, H Gu, B Wang, X Yao
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease, concomitant with allergic reactions to allergens. However, the exact mechanisms of allergen-induced immune responses in AD are not clear. The aim of this study is to explore the role of DC-SIGN in capturing and processing glycan-containing allergens and in the subsequent DC activation and T helper cell polarization in AD patients. METHODS: DC-SIGN expression on DCs from AD patients was analysed by confocal microscopy and flow cytometry...
August 9, 2016: Journal of Dermatological Science
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