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https://www.readbyqxmd.com/read/29915598/the-interaction-of-human-pathogenic-fungi-with-c-type-lectin-receptors
#1
REVIEW
Surabhi Goyal, Juan Camilo Castrillón-Betancur, Esther Klaile, Hortense Slevogt
Fungi, usually present as commensals, are a major cause of opportunistic infections in immunocompromised patients. Such infections, if not diagnosed or treated properly, can prove fatal. However, in most cases healthy individuals are able to avert the fungal attacks by mounting proper antifungal immune responses. Among the pattern recognition receptors (PRRs), C-type lectin receptors (CLRs) are the major players in antifungal immunity. CLRs can recognize carbohydrate ligands, such as β-glucans and mannans, which are mainly found on fungal cell surfaces...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29909133/tuberculin-skin-test-reaction-is-related-to-memory-but-not-naive-cd4-t-cell-responses-to-mycobacterial-stimuli-in-bcg-vaccinated-young-adults
#2
Magdalena Kowalewicz-Kulbat, Piotr Szpakowski, Camille Locht, Franck Biet, Paulina Kaplonek, Krzysztof T Krawczyk, Joël Pestel, Wieslawa Rudnicka
Bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis and the tuberculin skin test (TST) is the most widely used method to detect BCG take. However, subjects may remain TST-negative, even after several BCG administrations. To investigate some of the potential reasons underlying this inability of developing tuberculin sensitivity in response to BCG we compared the effect of different mycobacterial stimuli in the groups differently responding to tuberculin. TST was performed on 71 healthy adults aged 25-30 years, who had received BCG in their childhood, and considered TST-positive at ≥10 mm...
June 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29894153/chemoenzymatic-synthesis-of-n-glycan-positional-isomers-and-evidence-for-branch-selective-binding-by-monoclonal-antibodies-and-human-c-type-lectin-receptors
#3
Begoña Echeverria, Sonia Serna, Silvia Achilli, Corinne Vivès, Julie Pham, Michel Thépaut, Cornelis H Hokke, Franck Fieschi, Niels-Christian Reichardt
Here we describe a strategy for the rapid preparation of pure positional isomers of complex N-glycans to complement an existing array comprising a larger number of N-glycans and smaller glycan structures. The expanded array was then employed to study context-dependent binding of structural glycan fragments by monoclonal antibodies and C-type lectins. A partial enzymatic elongation of semi-protected core structures was combined with the protecting group aided separation of positional isomers by preparative HPLC...
June 12, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29870244/single-chain-glycopolymer-folding-via-host-guest-interactions-and-its-unprecedented-effect-on-dc-sign-binding
#4
Gokhan Yilmaz, Veselina Uzunova, Richard M Napier, C Remzi Becer
Reversible self-folding actions of natural biomacromolecules play crucial roles for specific and unique biological functions in Nature. Hence, controlled folding of single polymer chains has attracted significant attention in recent years. Herein, reversible single-chain folded glycopolymer structures in α-shape with different density of sugar moieties in the knot were created. The influence of folding as well as the sugar density in the knot was investigated on the binding capability with lectins, such as ConA, DC-SIGN and DC-SIGNR...
June 5, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29868908/the-major-surface-glycoprotein-of-pneumocystis-murina-does-not-activate-dendritic-cells
#5
Monica Sassi, Geetha Kutty, Gabriela A Ferreyra, Lisa R Bishop, Yueqin Liu, Ju Qiu, Da Wei Huang, Joseph A Kovacs
The major surface glycoprotein (Msg) is the most abundant surface protein of Pneumocystis species. Given that Msg is present on both the cyst and trophic form of Pneumocystis, and dendritic cells play a critical role in initiating host immune responses, we undertook studies to examine activation of bone marrow-derived myeloid dendritic cells by Msg purified from P. murina. Incubation of dendritic cells with Msg did not lead to increased expression of CD40, CD80, CD86, or MHCII, or increased secretion of any of 10 cytokines...
June 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29867967/mouse-dc-sign-cd209a-as-target-for-antigen-delivery-and-adaptive-immunity
#6
Sjoerd T T Schetters, Laura J W Kruijssen, Matheus H W Crommentuijn, Hakan Kalay, Jordi Ochando, Joke M M den Haan, Juan J Garcia-Vallejo, Yvette van Kooyk
The efficacy of vaccination studies aimed at targeting antigens to human DC-SIGN (hDC-SIGN) have been notoriously difficult to study in vivo , as eight dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) homologs have been described in mice. CD209a/SIGNR5 has been coined as the mouse DC-SIGN (mDC-SIGN) ortholog, based on its expression and location in the genome. Nonetheless, which properties of hDC-SIGN are covered by mDC-SIGN is poorly investigated. One of the most important functions of DC-SIGN is the induction of adaptive immunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29843788/the-lack-of-association-between-the-burden-of-monosodium-urate-crystals-assessed-with-dual-energy-computed-tomography-or-ultrasonography-with-cardiovascular-risk-in-the-commonly-high-risk-gout-patient
#7
Tristan Pascart, Benoist Capon, Agathe Grandjean, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak, Jean-François Budzik
BACKGROUND: Gout is associated with higher cardiovascular risk that increases with disease severity. The objective of this study was to explore the relationship between the extent of monosodium urate (MSU) crystal deposition, assessed with ultrasonography (US) and dual-energy computed tomography (DECT), and cardiovascular risk. METHODS: Gout patients were included in this cross-sectional study to undergo DECT scans for the assessment of total MSU volume deposition in the knees and feet, and US to evaluate the number of joints with the double contour (DC) sign...
May 29, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29732900/%C3%AE-1-6-fucosylated-complex-glycan-binding-lentil-lectin-enhances-in-vitro-hiv-1-infection-and-dc-sign-mediated-viral-capture-and-transmission-to-cd4-cells
#8
Muzafar Jan, Shallu Tomer, Sunil K Arora
This study was designated to study the effect of glycan composition on lectin-mediated inhibition of HIV-1 infection and transmission. We found that Lens culinaris agglutinin (LCA), an α(1-6)-fucosylated complex glycan-binding lectin, remarkably enhances the susceptibility of cells for HIV-1 infection and DC-SIGN-mediated capture and transmission. The role of glycan involvement was studied by using glycan-modified viruses produced in the presence of glycosidase inhibitors and mutant cell lines. The data suggests that the LCA-mediated enhancement in viral infection and trans-infection was not determined by the glycan composition of virus...
May 6, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29723162/hiv-1-replicates-and-persists-in-vaginal-epithelial-dendritic-cells
#9
Victor Pena-Cruz, Luis M Agosto, Hisashi Akiyama, Alex Olson, Yvetane Moreau, Jean-Robert Larrieux, Andrew Henderson, Suryaram Gummuluru, Manish Sagar
HIV-1 acquisition occurs most commonly after sexual contact. To establish infection, HIV-1 must infect cells that support high level replication, namely CD4+ T cells, which are absent from the outermost genital epithelium. Dendritic cells (DCs), present in mucosal epithelia, potentially facilitate HIV-1 acquisition. We show that vaginal epithelial DCs, termed CD1a+ VEDCs, are unlike other blood and tissue derived DCs because they express langerin but not DC-SIGN, and unlike skin-based langerin+ DC subset, Langerhans cells (LC), they do not harbor Birbeck granules...
May 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29671117/lewis-antigen-containing-icam-2-3-on-jurkat-leukemia-cells-interact-with-dc-sign-to-regulate-dc-functions
#10
Xin Jin, Qingpan Bu, Yingying Zou, Yunpeng Feng, Min Wei
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is an important C-type lectin and plays a critical role in the recognition of pathogens and self-antigens. It has recently been shown that DC-SIGN directly interacts with acute T lymphoblastic leukemia cells. However, the mechanism regulating DC-SIGN-dependent DC association as well as related functions is still elusive. Here we showed that DC-SIGN preferentially bound to a set of malignant T lymphocytes, including Jurkat, CCRF-HSB2 and CCRF-CEM...
April 18, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29666116/critical-influences-on-the-pathogenesis-of-follicular-lymphoma
#11
REVIEW
Ralf Küppers, Freda K Stevenson
The development of follicular lymphoma (FL) from a founder B cell with an upregulation of B-cell lymphoma 2 (BCL2), via the t(14;18) translocation, to a proliferating clone, poised to undergo further transformation to an aggressive lymphoma, illustrates the opportunistic Darwinian process of tumorigenesis. Protection against apoptosis allows an innocent cell to persist and divide, with dangerous accumulation of further mutational changes, commonly involving inactivation of chromatin-modifying genes. But this is not all...
May 24, 2018: Blood
https://www.readbyqxmd.com/read/29662482/targeting-mycobacterium-tuberculosis-antigens-to-dendritic-cells-via-the-dc-specific-icam3-grabbing-nonintegrin-receptor-induces-strong-t-helper-1-immune-responses
#12
Lis Noelia Velasquez, Philipp Stüve, Maria Virginia Gentilini, Maxine Swallow, Judith Bartel, Nils Yngve Lycke, Daniel Barkan, Mariana Martina, Hugo D Lujan, Hakan Kalay, Yvette van Kooyk, Tim D Sparwasser, Luciana Berod
Tuberculosis remains a major global health problem and efforts to develop a more effective vaccine have been unsuccessful so far. Targeting antigens (Ags) to dendritic cells (DCs) in vivo has emerged as a new promising vaccine strategy. In this approach, Ags are delivered directly to DCs via antibodies that bind to endocytic cell-surface receptors. Here, we explored DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) targeting as a potential vaccine against tuberculosis. For this, we made use of the hSIGN mouse model that expresses human DC-SIGN under the control of the murine CD11c promoter...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29655658/elucidating-the-mechanisms-of-action-of-saponin-derived-adjuvants
#13
REVIEW
Dante J Marciani
Numerous triterpenoid saponins are adjuvants that modify the activities of T cells and antigen-presenting cells, like dendritic cells (DCs). Saponins can induce either proinflammatory Th1/Th2 or sole anti-inflammatory Th2 immunities. Structure-activity relationships (SARs) have shown that imine-forming carbonyl groups are needed for T cell activation leading to induction of Th1/Th2 immunities. While saponins having different triterpenoid aglycons and oligosaccharide chains can activate DCs to induce Th1/Th2 immunoresponses, fucopyranosyl residues from their oligosaccharides by binding to the DC-SIGN receptor can bias DCs toward a sole Th2 immunity...
June 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29648611/fine-mapping-the-interaction-between-dc-sign-and-the-cytomegalovirus-envelope-glycoprotein-b
#14
Coraline Chéneau, Flora Coulon, Vanessa Porkolab, Franck Fieschi, Stéphanie Laurant, Diane Razanajaona-Doll, Jean-Jacques Pin, Eva Maria Borst, Martin Messerle, Céline Bressollette-Bodin, Franck Halary
Human cytomegalovirus (HCMV) is a leading cause of virally-induced congenital disorders and morbidities in immunocompromised individuals, i.e. transplant, cancer or AIDS patients. HCMV infects virtually all cell types through the envelope glycoprotein complex gH/gL/gO with our without a contribution of the pentameric gH/gL/pUL128L. Together with gH/gL, the HCMV envelope glycoprotein B (gB) contributes to the viral fusion machinery. We previously showed that gB is a ligand for the C-type lectin Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin (DC-SIGN) contributing to HCMV attachment to and infection of DC-SIGN expressing cells...
April 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29643243/inefficient-hiv-1-trans-infection-of-cd4-t-cells-by-macrophages-from-hiv-1-nonprogressors-is-associated-with-altered-membrane-cholesterol-and-dc-sign
#15
Diana C DeLucia, Charles R Rinaldo, Giovanna Rappocciolo
Professional antigen presenting cells (APC: myeloid dendritic cells (DC) and macrophages (MΦ); B lymphocytes) mediate highly efficient HIV-1 infection of CD4+ T cells, termed trans infection, that could contribute to HIV-1 pathogenesis. We have previously shown that lower cholesterol content in DC and B lymphocytes is associated with a lack of HIV-1 trans infection in HIV-1 infected nonprogressors (NP). Here we assessed whether HIV-1 trans infection mediated by another major APC, MΦ, is deficient in NP due to altered cholesterol metabolism...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29511377/differences-in-c-type-lectin-receptors-and-their-adaptor-molecules-in-the-peritoneal-fluid-of-patients-with-endometriosis-and-gynecologic-cancers
#16
Seung Geun Yeo, Yong Sung Won, Sang Hoon Kim, Dong Choon Park
Endometriosis, although not malignant, has clinically demonstrated properties of invasiveness and metastasis. The pathogenesis of endometriosis, however, has not yet been elucidated. The immunological differences between endometriosis and malignant gynecologic tumors were analyzed by assessing C-type lectin receptors, which are associated with innate immunity, and immunoglobulin secretion, which is associated with B cell adaptive immunity, in the peritoneal fluid of these patients. Peritoneal fluid samples were obtained from 42 patients with benign masses (control group), 38 with endometriosis, and 43 with gynecologic (ovarian, uterine, and cervical) cancers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29505573/clonorchis-sinensis-adult-derived-proteins-elicit-th2-immune-responses-by-regulating-dendritic-cells-via-mannose-receptor
#17
Lu Zhao, Mengchen Shi, Lina Zhou, Hengchang Sun, Xiaona Zhang, Lei He, Zeli Tang, Caiqin Wang, Yinjuan Wu, Tingjin Chen, Mei Shang, Xinyi Zhou, Zhipeng Lin, Xuerong Li, Xinbing Yu, Yan Huang
BACKGROUND: Clonorchis sinensis (C. sinensis) is the most widespread human liver fluke in East Asia including China and Korea. Clonorchiasis as a neglected tropical zoonosis, leads to serious economic and public health burden in China. There are considerable evidences for an etiological relation between chronic clonorchiasis and liver fibrosis in human beings. Liver fibrosis is a highly conserved and over-protected response to hepatic tissue injury. Immune cells including CD4+ T cell as well as dendritic cell (DC), and pro-fibrogenic cytokines like interleukin 4 (IL-4), IL-13 have been identified as vital manipulators in liver fibrogenesis...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29482715/expression-of-c-type-lectin-receptors-and-toll-like-receptors-in-decidua-of-patients-with-unexplained-recurrent-spontaneous-abortion
#18
Liang Xu, Tian Qiu, Yudong Wang, Yan Chen, Weiwei Cheng
In the present study, the mechanisms underlying the pathogenesis of unexplained recurrent spontaneous abortion (URSA) were explored. The protein and mRNA expression of two C-type lectin-like receptors (CLRs), namely dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and mannose receptor (MR), and two Toll-like receptors (TLRs), namely TLR2 and TLR4, in the decidua and dendritic cells (DCs) was compared between URSA patients and normal controls. URSA patients had significantly lower protein and mRNA expression of DC-SIGN and significantly higher expression of TLR2 and TLR4 in decidual tissues compared with normal controls...
August 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29463753/signal-peptide-of-hiv-envelope-protein-impacts-glycosylation-and-antigenicity-of-gp120
#19
Jason Yolitz, Catherine Schwing, Julia Chang, Donald Van Ryk, Fatima Nawaz, Danlan Wei, Claudia Cicala, James Arthos, Anthony S Fauci
The HIV-1 envelope protein (Env) of early-replicating viruses encodes several distinct transmission signatures. One such signature involves a reduced number of potential N-linked glycosylation sites (PNGs). This transmission signature underscores the importance of posttranslational modifications in the fitness of early-replicating isolates. An additional signature in Env involves the overrepresentation of basic amino acid residues at a specific position in the Env signal peptide (SP). In this report, we investigated the potential impact of this SP signature on gp120 glycosylation and antigenicity...
March 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29455681/human-dendritic-cell-sequestration-onto-the-necator-americanus-larval-sheath-during-ex-sheathing-a-possible-mechanism-for-immune-privilege
#20
A Hassan, D I Pritchard, A M Ghaemmaghami
Despite the profound health implications of Necator americanus infection in humans, many aspects of its interaction with the host immune system are poorly understood. Here we investigated the early events at the interface of N. americanus larvae (L3) and human dendritic cells (DCs). Our data show that co-culturing DCs and the larvae trigger ex-sheathing of hookworms rapidly where a majority of DCs are sequestered onto the larval sheath allowing the ex-sheathed larvae to migrate away unchallenged. Intriguingly, DCs show negligible interaction with the ex-sheathed larvae, alluding to differences between the surface chemistry of the larva and its sheath...
February 19, 2018: Parasitology
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