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C-type lectin

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https://www.readbyqxmd.com/read/29677385/identification-and-characterization-of-two-novel-c-type-lectins-from-the-larvae-of-housefly-musca-domestica-l
#1
Jing Zhou, Nai-Nai Fang, Ya Zheng, Kai-Yu Liu, Bin Mao, Li-Na Kong, Ya Chen, Hui Ai
Lectins and antimicrobial peptides (AMPs) are widely distributed in various insects and play crucial roles in primary host defense against pathogenic microorganisms. Two AMPs (cecropin and attacin) have been identified and characterized in the larvae of housefly. In this study, two novel C-type lectins (CTLs) were obtained from Musca domestica, while their agglutinating and antiviral properties were evaluated. Real-time PCR analysis showed that the mRNA levels of four immune genes (MdCTL1, MdCTL2, Cecropin, and Attacin) from M...
April 20, 2018: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29675368/mincle-in-the-innate-immune-response-of-mice-fungal-keratitis
#2
Guo-Rong Yu, Jing Lin, Jie Zhang, Cheng-Ye Che, Xu-Dong Peng, Cui Li, Li-Ting Hu, Guo-Qiang Zhu, Kun He, Gui-Qiu Zhao
AIM: To investigate how macrophage inducible C-type lectin (Mincle) influences inflammation in mice fungal keratitis induced by Aspergillus fumigatus ( A. fumigatus ). METHODS: C57BL/6 mice were infected with A. fumigatus after pretreated with Mincle agonist TDB or Mincle neutralizing antibody (MincleAb), taking DMSO or IgG as control group respectively. The cornea lesions were monitored with slit-lamp microscope and evaluated by clinical score. Mincle expression was assessed using reverse transcription-ploymerase chain reaction (RT-PCR) and immunostaining...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29671117/lewis-antigen-containing-icam-2-3-on-jurkat-leukemia-cells-interact-with-dc-sign-to-regulate-dc-functions
#3
Xin Jin, Qingpan Bu, Yingying Zou, Yunpeng Feng, Min Wei
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is an important C-type lectin and plays a critical role in the recognition of pathogens and self-antigens. It has recently been shown that DC-SIGN directly interacts with acute T lymphoblastic leukemia cells. However, the mechanism regulating DC-SIGN-dependent DC association as well as related functions is still elusive. Here we showed that DC-SIGN preferentially bound to a set of malignant T lymphocytes, including Jurkat, CCRF-HSB2 and CCRF-CEM...
April 18, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29665849/an-innovative-immunotherapeutic-strategy-for-ovarian-cancer-clec10a-and-glycomimetic-peptides
#4
Laura L Eggink, Katherine F Roby, Robert Cote, J Kenneth Hoober
BACKGROUND: Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by human peripheral immature dendritic cells, dendritic cells in the skin, alternatively-activated (M2a) macrophages, and to lesser extents by several other types of tissues. CLEC10A is an endocytic receptor on antigen-presenting cells and has been proposed to play an important role in maturation of dendritic cells and initiation of an immune response...
April 17, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29651041/duplication-and-diversification-of-lectin-receptor-like-kinases-lecrlk-genes-in-soybean
#5
Ping-Li Liu, Yuan Huang, Peng-Hao Shi, Meng Yu, Jian-Bo Xie, LuLu Xie
Lectin receptor-like kinases (LecRLKs) play important roles in plant development and stress responses. Although genome-wide studies of LecRLKs have been performed in several species, a comprehensive analysis including evolutionary, structural and functional analysis has not been carried out in soybean (Glycine max). In this study, we identified 185 putative LecRLK genes in the soybean genome, including 123 G-type, 60 L-type and 2 C-type LecRLK genes. Tandem duplication and segmental duplication appear to be the main mechanisms of gene expansion in the soybean LecRLK (GmLecRLK) gene family...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29648611/fine-mapping-the-interaction-between-dc-sign-and-the-cytomegalovirus-envelope-glycoprotein-b
#6
Coraline Chéneau, Flora Coulon, Vanessa Porkolab, Franck Fieschi, Stéphanie Laurant, Diane Razanajaona-Doll, Jean-Jacques Pin, Eva Maria Borst, Martin Messerle, Céline Bressollette-Bodin, Franck Halary
Human cytomegalovirus (HCMV) is a leading cause of virally-induced congenital disorders and morbidities in immunocompromised individuals, i.e. transplant, cancer or AIDS patients. HCMV infects virtually all cell types through the envelope glycoprotein complex gH/gL/gO with our without a contribution of the pentameric gH/gL/pUL128L. Together with gH/gL, the HCMV envelope glycoprotein B (gB) contributes to the viral fusion machinery. We previously showed that gB is a ligand for the C-type lectin Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin (DC-SIGN) contributing to HCMV attachment to and infection of DC-SIGN expressing cells...
April 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29627477/distribution-of-mannose-receptor-in-blunt-snout-bream-megalobrama-amblycephala-during-the-embryonic-development-and-its-immune-response-to-the-challenge-of-aeromonas-hydrophila
#7
Changsong Wu, Xiaoheng Zhao, Sarath Babu V, Gailing Yuan, Weimin Wang, Jianguo Su, Xiaoling Liu, Li Lin
The mannose receptor (MR) is a type I transmembrane protein. Its ectodomain has eight C-type lectin-like domains, which are able to recognize and mediate the phagocytosis of a wide range of pathogens. Comprehensive studies have revealed that mammalian MR is widely distributed in the mononuclear phagocyte system (MPS, previously known as the reticuloendothelial system) and play a key role both in the physiological clearance and cell activation. Hitherto, neither the MR distribution, nor the function of clearance and cell activation has been investigated in fish...
April 6, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29625550/classification-and-phylogenetic-analyses-of-the-arabidopsis-and-tomato-g-type-lectin-receptor-kinases
#8
Marcella A Teixeira, Alex Rajewski, Jiangman He, Olenka G Castaneda, Amy Litt, Isgouhi Kaloshian
BACKGROUND: Pathogen perception by plants is mediated by plasma membrane-localized immune receptors that have varied extracellular domains. Lectin receptor kinases (LecRKs) are among these receptors and are subdivided into 3 classes, C-type LecRKs (C-LecRKs), L-type LecRKs (L-LecRKs) and G-type LecRKs (G-LecRKs). While C-LecRKs are represented by one or two members in all plant species investigated and have unknown functions, L-LecRKs have been characterized in a few plant species and have been shown to play roles in plant defense against pathogens...
April 6, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29625245/itraq-based-quantitative-proteomic-analysis-of-procambarus-clakii-hemocytes-during-spiroplasma-eriocheiris-infection
#9
Yinbin Xu, Wenjing Hao, Tao Xiang, Haifeng Zhou, Wen Wang, Qingguo Meng, Zhengfeng Ding
As a new-found aquaculture pathogen, Spiroplasma eriocheiris, has resulted in inconceivable economic losses in aquaculture. In the infection of S. eriocheiris, the Procambarus clakii hemocytes have indicated to be major target cells. What was designed to examine in our study is the hemocytes' immune response at the protein levels. Before the pathogen was injected and after 192 h of post-injection, the differential proteomes of the crayfish hemocytes were analyzed immediately by isobaric tags for relative and absolute quantization (iTRAQ) labeling, followed by liquid chromatogramphytandem mass spectrometry (LC-MS/MS)...
April 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29619418/the-role-of-intestinal-c-type-regenerating-islet-derived-3-lectins-for-nonalcoholic-steatohepatitis
#10
Sena Bluemel, Lirui Wang, Cameron Martino, Suhan Lee, Yanhan Wang, Brandon Williams, Angela Horvath, Vanessa Stadlbauer, Karsten Zengler, Bernd Schnabl
C-type regenerating islet derived-3 (Reg3) lectins defend against pathogens and keep commensal bacteria at a distance. Deficiency of Reg3g and Reg3b facilitates alcohol-induced bacterial translocation and alcoholic liver disease. Intestinal Reg3g is down-regulated in animal models of diet-induced obesity, but the functional consequences for nonalcoholic steatohepatitis (NASH) are unknown. The aim of this study was to investigate the role of Reg3 lectins in NASH. NASH was induced by a Western-style fast-food diet in mice deficient for Reg3g or Reg3b and in transgenic mice overexpressing Reg3g in intestinal epithelial cells ( Reg3g Tg)...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29617297/the-combinational-use-of-crispr-cas9-and-targeted-toxin-technology-enables-efficient-isolation-of-bi-allelic-knockout-non-human-mammalian-clones
#11
Satoshi Watanabe, Takayuki Sakurai, Shingo Nakamura, Kazuchika Miyoshi, Masahiro Sato
Recent advances in genome editing systems such as clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease (CRISPR/Cas9) have facilitated genomic modification in mammalian cells. However, most systems employ transient treatment with selective drugs such as puromycin to obtain the desired genome-edited cells, which often allows some untransfected cells to survive and decreases the efficiency of generating genome-edited cells. Here, we developed a novel targeted toxin-based drug-free selection system for the enrichment of genome-edited cells...
April 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29616193/a-comprehensive-in-silico-analysis-of-regulatory-snps-of-human-clec7a-gene-and-its-validation-as-genotypic-and-phenotypic-disease-marker-in-recurrent-vulvovaginal-infections
#12
Namarta Kalia, Manpreet Kaur, Sujata Sharma, Jatinder Singh
Recurrent Vulvovaginal infections (RVVI) are the commonly reported microbiological syndrome affecting millions of women globally. Various molecules of innate immune system are instrumental in clearance of these microbial pathogens, thus suggested as one of the most important contributing factor in determining the disease outcome. Dendritic cell-associated C-type lectin-1 (Dectin-1) is an important molecule of innate immunity that is primarily known for its role in antifungal defenses. However, role of dectin-1 in recognition of other pathogens is also documented...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29616019/the-syk-coupled-c-type-lectin-receptors-dectin-2-and-dectin-3-are-involved-in-paracoccidioides-brasiliensis-recognition-by-human-plasmacytoid-dendritic-cells
#13
Nycolas Willian Preite, Claudia Feriotti, Dhêmerson Souza de Lima, Bruno Borges da Silva, Antônio Condino-Neto, Alessandra Pontillo, Vera Lúcia Garcia Calich, Flávio Vieira Loures
Plasmacytoid dendritic cells (pDCs), which have been extensively studied in the context of the immune response to viruses, have recently been implicated in host defense mechanisms against fungal infections. Nevertheless, the involvement of human pDCs during paracoccidioidomycosis (PCM), a fungal infection endemic to Latin America, has been scarcely studied. However, pDCs were found in the cutaneous lesions of PCM patients, and in pulmonary model of murine PCM these cells were shown to control disease severity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29609025/regulation-of-growth-intestinal-microbiota-non-specific-immune-response-and-disease-resistance-of-sea-cucumber-apostichopus-japonicus-selenka-in-biofloc-systems
#14
Jinghua Chen, Yichao Ren, Yuquan Li, Bin Xia
Bioflocs are not only a source of supplemental nutrition but also provide substantial probiotic bacteria and bioactive compounds, which play an important role in improving physiological health of aquatic organisms. A 60-day experiment was conducted to investigate the growth, intestinal microbiota, non-specific immune response and disease resistance of sea cucumber in biofloc systems with different carbon sources (glucose, sucrose and starch). Control (no biofloc) and three biofloc systems were set up, and each group has three replicates...
March 30, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29608407/epitope-mapping-of-monoclonal-antibody-pmab-48-against-dog-podoplanin
#15
Shinji Yamada, Mika K Kaneko, Shunsuke Itai, Yao-Wen Chang, Takuro Nakamura, Miyuki Yanaka, Satoshi Ogasawara, Takeshi Murata, Hiroaki Uchida, Hideaki Tahara, Hiroyuki Harada, Yukinari Kato
Podoplanin (PDPN), a type I transmembrane sialoglycoprotein, is expressed on normal renal podocytes, pulmonary type I alveolar cells, and lymphatic endothelial cells. Increased expression of PDPN in cancers is associated with poor prognosis and hematogenous metastasis through interactions with C-type lectin-like receptor 2 (CLEC-2) on platelets. We previously reported a novel PMab-48 antibody, which is an anti-dog PDPN (dPDPN) monoclonal antibody (mAb) recognizing PDPN expressed in lymphatic endothelial cells...
April 2, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29601951/genome-wide-identification-of-lectin-receptor-kinases-in-pear-functional-characterization-of-the-l-type-lecrlk-gene-pblrk138
#16
Na Ma, Chunxiao Liu, Hui Li, Jinyan Wang, Baolong Zhang, Jing Lin, Youhong Chang
Lectin receptor-like kinases (LecRLKs) are membrane-bound receptors that are believed to be involved in biotic and abiotic stress responses. However, little is known about the LecRLK family in pear. In this study, a total of 172 LecRLK genes were first identified in the entire pear genome. The 172 LecRLKs were divided into three types (111 G-, 59 L- and two C-types) based on their structure and phylogenetic relationships. LecRLK gene expressions were detected in different pear tissues including roots, stems, leaves, flowers and fruits, and the most of the 11 selected LecRLKs exhibited similar expression patterns...
March 27, 2018: Gene
https://www.readbyqxmd.com/read/29601103/characterization-of-a-novel-mouse-strain-expressing-human-siglec-8-only-on-eosinophils
#17
Jeremy A O'Sullivan, Yadong Wei, Daniela J Carroll, Liliana Moreno-Vinasco, Yun Cao, Fengrui Zhang, James J Lee, Zhou Zhu, Bruce S Bochner
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a human cell surface protein expressed exclusively on eosinophils, mast cells, and basophils that, when engaged, induces eosinophil apoptosis and inhibits mast cell mediator release. This makes Siglec-8 a promising therapeutic target to treat diseases involving these cell types. However, preclinical studies of Siglec-8 targeting in vivo are lacking because this protein is only found in humans, apes, and some monkeys. Therefore, we have developed a mouse strain in which SIGLEC8 transcription is activated by Cre recombinase and have crossed this mouse with the eoCre mouse to achieve eosinophil-specific expression...
March 30, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29599490/interaction-of-glycolipids-with-the-macrophage-surface-receptor-mincle-a-systematic-molecular-dynamics-study
#18
Christian A Söldner, Anselm H C Horn, Heinrich Sticht
Synthetic analogues of mycobacterial trehalose-dimycolate such as trehalose acyl esters have been proposed as novel adjuvants for vaccination. They induce an immune response by binding to the macrophage C-type lectin receptor Mincle. The binding site of trehalose is known, but there is yet only very limited structural information about the binding mode of the acyl esters. Here, we performed a systematic molecular dynamics study of trehalose mono-and diesters with different chain lengths. All acyl chains investigated exhibited a high flexibility and interacted almost exclusively with a hydrophobic groove on Mincle...
March 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29593811/expression-of-selected-genes-of-dendritic-and-treg-cells-in-blood-and-skin-of-morphea-patients-treated-with-uva1-phototherapy
#19
Agnieszka J Osmola-Mańkowska, Ewa Teresiak-Mikołajczak, Michał J Kowalczyk, Ryszard W Żaba, Zygmunt Adamski, Aleksandra Dańczak-Pazdrowska
Introduction: Morphea is a chronic autoimmune disease characterized by fibrosis of the skin. Dendritic cells (DC) and regulatory T cells (Tregs) play a significant role in development of autoimmune and tolerance mechanisms. The aim of the study was to establish the expression of selected genes of plasmacytoid and myeloid DC, Treg cells, and the microenvironment of cytokines (interleukin-17A (IL-17A), transforming growth factor β (TGF-β)) in blood and skin of morphea patients. In addition, the effect of UVA1 phototherapy on expression of the aforementioned genes was evaluated...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29581532/c-type-lectins-in-immunity-and-homeostasis
#20
REVIEW
Gordon D Brown, Janet A Willment, Lauren Whitehead
The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands and that regulate a diverse range of physiological functions. Most research attention has focused on the ability of C-type lectins to function in innate and adaptive antimicrobial immune responses, but these proteins are increasingly being recognized to have a major role in autoimmune diseases and to contribute to many other aspects of multicellular existence. Defects in these molecules lead to developmental and physiological abnormalities, as well as altered susceptibility to infectious and non-infectious diseases...
March 26, 2018: Nature Reviews. Immunology
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