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C-type lectin

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https://www.readbyqxmd.com/read/29449845/regulation-of-c-type-lectin-receptor-mediated-antifungal-immunity
#1
REVIEW
Juan Tang, Guoxin Lin, Wallace Y Langdon, Lijian Tao, Jian Zhang
Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29447367/endometrial-natural-killer-nk-cells-reveal-a-tissue-specific-receptor-repertoire
#2
D Feyaerts, T Kuret, B van Cranenbroek, S van der Zeeuw-Hingrez, O W H van der Heijden, A van der Meer, I Joosten, R G van der Molen
STUDY QUESTION: Is the natural killer (NK) cell receptor repertoire of endometrial NK (eNK) cells tissue-specific? SUMMARY ANSWER: The NK cell receptor (NKR) expression profile in pre-pregnancy endometrium appears to have a unique tissue-specific phenotype, different from that found in NK cells in peripheral blood, suggesting that these cells are finely tuned towards the reception of an allogeneic fetus. WHAT IS KNOWN ALREADY: NK cells are important for successful pregnancy...
February 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29444839/reverse-genetics-demonstrate-the-role-of-mucosal-c-type-lectins-in-food-particle-selection-in-the-oyster-crassostrea-virginica
#3
Emmanuelle Pales Espinosa, Bassem Allam
Prey selection governs species interactions and regulates physiological energetics of individuals and populations. Suspension-feeding bivalves represent key species in coastal and estuarine systems for their ecological and economic value. These animals are able to sort and selectively ingest nutritious microalgae from dilute and composite mixtures of particulate matter. This aptitude was suggested to be mediated by interactions between carbohydrates associated with the surface of microalgae and C-type lectins present in mucus covering the feeding organs although a direct, unequivocal, role of lectins in food sorting in bivalves remains elusive...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29427319/distinguishing-myelofibrosis-from-polycythemia-vera-and-essential-thrombocythemia-the-utility-of-enumerating-circulating-stem-cells-with-aberrant-hmicl-expression-by-flow-cytometry
#4
L L Herborg, L Nederby, H C Hasselbalch, A Aggerholm, A S Roug
INTRODUCTION: Diagnosing BCR-ABL negative myeloproliferative neoplasms (MPN) may be challenging due to overlapping features and lack of robust discriminatory parameters, especially between essential thrombocythemia (ET) and prefibrotic myelofibrosis (MF). Circulating immature hematopoietic cells are variably present in polycythemia vera (PV), ET, and MF. The C-type lectin hMICL is aberrantly expressed on hematopoietic stem cells in the majority of acute myeloid leukemia patients. However, the hMICL expression in MPN, having varying propensity of leukemic transformation, is unsettled...
February 10, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29425774/a-membrane-type-surfactant-protein-d-sp-d-suppresses-macrophage-mediated-cytotoxicity-in-swine-endothelial-cells
#5
Patmika Jiaravuthisan, Akira Maeda, Chihiro Takakura, Han-Tang Wang, Rieko Sakai, Afifah Mohd Shabri, Pei-Chi Lo, Rei Matsuura, Tasuku Kodama, Hiroshi Eguchi, Hiroomi Okuyama, Shuji Miyagawa
OBJECTIVE: Surfactant protein D (SP-D), which is secreted mainly in the lung, is an oligometric C type lectin that promotes phagocytosis by binding to carbohydrates on microbial surfaces. SP-D can also bind SIRPα, leading to a decrease in cytokine production by monocytes/macrophages. In the present study, we examined the possibility that SP-D suppresses macrophage-mediated xenogeneic cytotoxicity, by creating a membrane-type SP-D. METHODS: The cDNA for the carbohydrate recognition domain (CRD) of human SP-D was switched to that of a membrane-type protein, collectin placenta 1 (CL-P1), with a Flag-tag...
February 6, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29414772/fungal-melanin-stimulates-surfactant-protein-d-mediated-opsonization-of-and-host-immune-response-to-em-aspergillus-fumigatus-em-spores
#6
Sarah Sze Wah Wong, Manjusha Rani, Eswari Dodagatta-Marri, Oumaima Ibrahim-Granet, Uday Kishore, Jagadeesh Bayry, Jean-Paul Latgé, Arvind Sahu, Taruna Madan, Vishukumar Aimanianda
Surfactant protein D (SP-D), a C-type lectin and pattern-recognition soluble factor, plays an important role in immune surveillance to detect and eliminate human pulmonary pathogens. SPD has been shown to protect against infections with the most ubiquitous airborne fungal pathogen, <em>Aspergillus fumigatus</em>, but the fungal surface component(s) interacting with SP-D is unknown. Here, we show that SP-D binds to melanin pigment on the surface of <em>A. fumigatus</em> dormant spores (conidia)...
February 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29411522/mapping-the-clec12a-expression-on-myeloid-progenitors-in-normal-bone-marrow-implications-for-understanding-clec12a-related-cancer-stem-cell-biology
#7
Marie Bill, Peter B van Kooten Niekerk, Petter S Woll, Laura Laine Herborg, Anne Stidsholt Roug, Peter Hokland, Line Nederby
The C-type lectin domain family 12, member A (CLEC12A) receptor has emerged as a leukaemia-associated and cancer stem cell marker in myeloid malignancies. However, a detailed delineation of its expression in normal haematopoiesis is lacking. Here, we have characterized the expression pattern of CLEC12A on the earliest stem- and myeloid progenitor subsets in normal bone marrow. We demonstrate distinct CLEC12A expression in the classically defined myeloid progenitors, where on average 39.1% (95% CI [32.5;45.7]) of the common myeloid progenitors (CMPs) expressed CLEC12A, while for granulocyte-macrophage progenitors and megakaryocyte-erythroid progenitors (MEPs), the average percentages were 81...
February 7, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29401627/molecular-basis-for-intestinal-mucin-recognition-by-galectin-3-and-c-type-lectins
#8
Charlotte Leclaire, Karine Lecointe, Patrick A Gunning, Sandra Tribolo, Devon W Kavanaugh, Alexandra Wittmann, Dimitrios Latousakis, Donald A MacKenzie, Norihito Kawasaki, Nathalie Juge
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein-carbohydrate interactions. We used a combination of structural, biochemical, biophysical, and cell-based approaches to decipher the specificity of the interaction between mucin glycans and mammalian lectins expressed in the gut, including galectin (Gal)-3 and C-type lectin receptors. Gal-3 differentially recognized intestinal mucins with different O-glycosylation profiles, as determined by mass spectrometry (MS). Modification of mucin glycosylation, via chemical treatment leading to a loss of terminal glycans, promoted the interaction of Gal-3 to poly- N-acetyllactosamine...
January 29, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29401615/differential-susceptibility-of-dectin-1-isoforms-to-functional-inactivation-by-neutrophil-and-fungal-proteases
#9
James S Griffiths, Aiysha Thompson, Matthew Stott, Ankita Benny, Natalie A Lewis, Philip R Taylor, Julian Forton, Sarah Herrick, Selinda J Orr, Eamon P McGreal
Patients with cystic fibrosis (CF) experience chronic or recurrent bacterial and fungal lung infections. Many patients with CF cannot effectively clear Aspergillus from their lungs. This may result in IgE sensitization and the development of allergic bronchopulmonary aspergillosis, or invasive infections, such as Aspergillus bronchitis. Lung disease in patients with CF is associated with neutrophil-dominated inflammation and elevated levels of the serine protease, neutrophil elastase (NE). Various C-type lectin-like receptors (CLRs), including Dectin-1 and Dectin-2, are involved in the immune response to Aspergillus...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29400702/integrin-cd11b-negatively-regulates-mincle-induced-signaling-via-the-lyn-sirp%C3%AE-shp1-complex
#10
Quanri Zhang, Wook-Bin Lee, Ji-Seon Kang, Lark Kyun Kim, Young-Joon Kim
During mycobacteria infection, anti-inflammatory responses allow the host to avoid tissue damage caused by overactivation of the immune system; however, little is known about the negative modulators that specifically control mycobacteria-induced immune responses. Here we demonstrate that integrin CD11b is a critical negative regulator of mycobacteria cord factor-induced macrophage-inducible C-type lectin (Mincle) signaling. CD11b deficiency resulted in hyperinflammation following mycobacterial infection. Activation of Mincle by mycobacterial components turns on not only the Syk signaling pathway but also CD11b signaling and induces formation of a Mincle-CD11b signaling complex...
February 5, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29394131/epitope-mapping-of-monoclonal-antibody-pmab-52-against-cat-podoplanin
#11
Yao-Wen Chang, Mika K Kaneko, Shinji Yamada, Yukinari Kato
The mucin-type membrane glycoprotein podoplanin (PDPN) is frequently overexpressed in numerous malignant cancers, including squamous cell carcinoma, germinal neoplasia, mesothelioma, lung cancer, oral cancer, and brain tumor. PDPN expression is strongly associated with cancer progression and poor prognosis. Furthermore, PDPN binds to C-type lectin-like receptor 2 (CLEC-2) on platelets, followed by PDPN-mediated platelet aggregation to facilitate tumor metastasis. We have previously reported a novel anti-cat PDPN (cPDPN) monoclonal antibody (mAb), PMab-52, which specifically detects cPDPN using flow cytometry analysis and successfully identifies cPDPN in feline squamous cell carcinomas...
February 2, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29389944/genetic-variation-in-the-c-type-lectin-receptor-clec4m-in-type-1-von-willebrand-disease-patients
#12
Eric Manderstedt, Christina Lind-Halldén, Stefan Lethagen, Christer Halldén
von Willebrand factor (VWF) levels in healthy individuals and in patients with type 1 von Willebrand disease (VWD) are influenced by genetic variation in several genes, e.g. VWF, ABO, STXBP5 and CLEC4M. This study aims to screen comprehensively for CLEC4M variants and investigate their association with type 1 VWD in the Swedish population. In order to screen for CLEC4M variants, the CLEC4M gene region was re-sequenced and the polymorphic neck region was genotyped in 106 type 1 VWD patients from unrelated type 1 VWD families...
2018: PloS One
https://www.readbyqxmd.com/read/29386115/cd209a-synergizes-with-dectin-2-and-mincle-to-drive-severe-th17-cell-mediated-schistosome-egg-induced-immunopathology
#13
Parisa Kalantari, Yoelkys Morales, Emily A Miller, Luis D Jaramillo, Holly E Ponichtera, Marcel A Wuethrich, Cheolho Cheong, Maria C Seminario, Joanne M Russo, Stephen C Bunnell, Miguel J Stadecker
The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL-23 produced by dendritic cells that express CD209a (SIGNR5), a C-type lectin receptor (CLR) related to human DC-SIGN. Here, we show that CD209a-deficient CBA mice display decreased Th17 responses and are protected from severe immunopathology. In vitro, CD209a augments the egg-induced IL-1β and IL-23 production initiated by the related CLRs Dectin-2 and Mincle...
January 30, 2018: Cell Reports
https://www.readbyqxmd.com/read/29370452/n-carboxyanhydride-polymerization-of-glycopolypeptides-that-activate-antigen-presenting-cells-through-dectin-1-and-2
#14
Matthew Zhou, Corleone S Delaveris, Jessica R Kramer, Justin A Kenkel, Edgar G Engleman, Carolyn R Bertozzi
The C-type lectins Dectin-1 and Dectin-2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures. These receptors are promising targets for immune stimulatory adjuvants in the context of vaccine development and cancer immune therapy. However, currently available agonist ligands are heterogeneous glycoconjugates and polysaccharides from natural sources. Here, we designed and synthesized the first chemically-defined ligands for Dectin-1 and -2. They comprised glycopolypeptides bearing mono-, di-, and trisaccharides and were built via polymerization of glycosylated N-carboxyanhydrides...
January 25, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29361560/transient-loss-of-venous-integrity-during-developmental-vascular-remodeling-leads-to-red-blood-cell-extravasation-and-clearance-by-lymphatic-vessels
#15
Yang Zhang, Nina Daubel, Simon Stritt, Taija Mäkinen
Maintenance of blood vessel integrity is critical for vascular homeostasis and mainly controlled at the level of endothelial cell (EC) junctions. Regulation of endothelial integrity has largely been investigated in the mature quiescent vasculature. Less is known how integrity is maintained during vascular growth and remodeling involving extensive junctional reorganization. Here we show that embryonic mesenteric blood vascular remodeling is associated with a transient loss of venous integrity and concomitant extravasation of red blood cells (RBC), followed by their clearance by the developing lymphatic vessels...
January 22, 2018: Development
https://www.readbyqxmd.com/read/29355515/spliceosome-associated-protein-130-exacerbates-alcohol-induced-liver-injury-by-inducing-nlrp3-inflammasome-mediated-il1%C3%AE-in-mice
#16
Jong Won Kim, Yoon-Seok Roh, Hyeneui Jeong, Ho-Keun Yi, Min-Ho Lee, Chae Woong Lim, Bumseok Kim
Excessive alcohol consumption leads to chronic liver diseases. Macrophage-inducible C-type lectin (Mincle) is a C-type lectin receptor that recognizes spliceosome-associated protein 130 (SAP130) known as an endogenous ligand released from dying cells. Our aim was to examine the role of Mincle-SAP130 in the pathogenesis of alcoholic liver disease. Alcohol-induced liver injury was induced in wild-type (WT) and Mincle knout-out (KO) mice using a chronic-binge ethanol-feeding model. Mincle KO mice showed significant lower hepatic steatosis, inflammation with neutrophil infiltration, and fibrosis compared to WT mice after alcohol feeding...
January 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29345346/galectin-3-type-c-self-association-on-neutrophil-surfaces-the-carbohydrate-recognition-domain-regulates-cell-function
#17
Martina Sundqvist, Amanda Welin, Jonas Elmwall, Veronica Osla, Ulf J Nilsson, Hakon Leffler, Johan Bylund, Anna Karlsson
Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen-like N-domain. Both domains are required for galectin-3 to induce cellular effects; a C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking the N-domain, binds cell surface glycoconjugates but does not induce cellular effects since cross-linking promoted by the N-domain is thought to be required. Instead, galectin-3C is proposed to antagonize the effects of galectin-3 by competing for binding sites...
January 10, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29325991/bothrops-jararaca-accessory-venom-gland-is-an-ancillary-source-of-toxins-to-the-snake
#18
Richard Hemmi Valente, Milene Schmidt Luna, Ursula Castro de Oliveira, Milton Yutaka Nishiyama-Junior, Inácio de Loiola Junqueira-de-Azevedo, José Antonio Portes-Junior, Patricia Bianca Clissa, Luciana Godoy Viana, Leonardo Sanches, Ana Maria Moura-da-Silva, Jonas Perales, Norma Yamanouye
In Viperidae snakes, it has been attributed to the main venom gland, a component of the venom gland apparatus, the function of synthesizing all venom toxins and storing them inside a basal-central lumen. However, the role of the accessory gland is still unknown. Here, we analyzed the proteome and the transcriptome of the accessory gland during venom production and secretion cycle. We showed that the accessory gland expresses and synthesizes toxins that are similar to those produced by the main venom gland such as C-type lectin/C-type lectin-like proteins, metalloproteinase, phospholipase A2, cysteine rich secretory protein, nerve growth factor, vascular endothelial growth factor, serine proteinase, and l-amino acid oxidase...
January 8, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29324290/ross-river-virus-envelope-glycans-contribute-to-disease-through-activation-of-the-host-complement-system
#19
Bronwyn M Gunn, Jennifer E Jones, Reed S Shabman, Alan C Whitmore, Sanjay Sarkar, Lance K Blevins, Thomas E Morrison, Mark T Heise
Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis. As MBL binds to carbohydrates, we hypothesized that N-linked glycans on the RRV envelope glycoproteins act as ligands for MBL. Using a panel of RRV mutants lacking the envelope N-linked glycans, we found that MBL deposition onto infected cells was dependent on the E2 glycans...
January 8, 2018: Virology
https://www.readbyqxmd.com/read/29321242/adhesion-growth-regulatory-galectins-tested-in-combination-evidence-for-formation-of-hybrids-as-heterodimers
#20
Michelle C Miller, Anna-Kristen Ludwig, Kanin Wichapong, Herbert Kaltner, Jürgen Kopitz, Hans-Joachim Gabius, Kevin H Mayo
The delineation of the physiological significance of protein (lectin)-glycan recognition and the structural analysis of individual lectins have directed our attention to studying them in combination. In this report, we tested the hypothesis of hybrid formation by using binary mixtures of homodimeric galectins-1 and -7 as well as a proteolytically truncated version of chimera-type galectin-3. Initial supportive evidence is provided by affinity chromatography using resin-presented galectin-7. Intriguingly, extent of cell binding by cross-linking of surface counter-receptor increased significantly for monomeric galectin-3 form by presence of galectin-1 or -7...
January 10, 2018: Biochemical Journal
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