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C-type lectin

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https://www.readbyqxmd.com/read/28210565/label-free-proteome-analysis-of-plasma-from-patients-with-breast-cancer-stage-specific-protein-expression
#1
Marina Duarte Pinto Lobo, Frederico Bruno Mendes Batista Moreno, Gustavo Henrique Martins Ferreira Souza, Sara Maria Moreira Lima Verde, Renato de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira
Breast cancer is one of the most commonly diagnosed types of cancer among women. Breast cancer mortality rates remain high probably because its diagnosis is hampered by inaccurate detection methods. Since changes in protein expression as well as modifications in protein glycosylation have been frequently reported in cancer development, the aim of this work was to study the differential expression as well as modifications of glycosylation of proteins from plasma of women with breast cancer at different stages of disease (n = 30) compared to healthy women (n = 10)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28206701/differential-responses-of-helicoverpa-armigera-c-type-immunlectin-genes-to-the-endoparasitoid-campoletis-chlorideae
#2
Xiong-Ya Wang, Su-Fen Bai, Xin Li, Shi-Heng An, Xin-Ming Yin, Xian-Chun Li
The C-type lectins mediate nonself recognition in insects. The previous studies focused on host immunlectin response to bacterial infection; however, the molecular basis of immunlectin reactions to endoparasitoids has not been elucidated. The present study investigated the effect of parasitization by Campoletis chlorideae on hemagglutination activity (HA; defined as the ability of lectin to agglutinate erythrocytes or other cells), and transcriptional expression of C-type immunlectin genes in the larval host, Helicoverpa armigera...
February 16, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28203237/activation-of-the-wnt-pathway-by-mycobacterium-tuberculosis-a-wnt-wnt-situation
#3
REVIEW
Tomás Villaseñor, Edgardo Madrid-Paulino, Rafael Maldonado-Bravo, Antonio Urbán-Aragón, Leonor Pérez-Martínez, Gustavo Pedraza-Alva
Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of tuberculosis (TB), a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors expressed on the host innate immune cells, including Toll-like receptors, Nod-like receptors, and C-type lectin receptors like Dectin-1, the Mannose receptor, and DC-SIGN...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28202166/m1-macrophage-triggered-by-mincle-leads-to-a-deterioration-of-acute-kidney-injury
#4
Tsuyoshi Inoue
In the early stage of acute kidney injury, M1 macrophages are proinflammatory and destructive. In this study, Lv et al. reveal that Mincle (macrophage-inducible C-type lectin, Clec4e) is expressed on M1 macrophages in acute kidney injury, and the kidney is protected in a murine model of cisplatin-induced renal injury by inhibiting Mincle expression on macrophages. Mincle expression is regulated by Toll-like receptor 4/nuclear factor κB signaling, and Mincle maintains the inflammatory phenotype through spleen tyrosine kinase signaling, leading to acute kidney injury...
March 2017: Kidney International
https://www.readbyqxmd.com/read/28199361/bombyx-mori-and-aedes-aegypti-form-multi-functional-immune-complexes-that-integrate-pattern-recognition-melanization-coagulants-and-hemocyte-recruitment
#5
Dennis R Phillips, Kevin D Clark
The innate immune system of insects responds to wounding and pathogens by mobilizing multiple pathways that provide both systemic and localized protection. Key localized responses in hemolymph include melanization, coagulation, and hemocyte encapsulation, which synergistically seal wounds and envelop and destroy pathogens. To be effective, these pathways require a targeted deposition of their components to provide protection without compromising the host. Extensive research has identified a large number of the effectors that comprise these responses, but questions remain regarding their post-translational processing, function, and targeting...
2017: PloS One
https://www.readbyqxmd.com/read/28198086/calcium-independent-activation-of-an-allosteric-network-in-langerin-by-heparin-oligosaccharides
#6
Jonas Hanske, Robert Wawrzinek, Andreas Geissner, Eike-Christian Wamhoff, Katrin Sellrie, Henrik Schmidt, Peter H Seeberger, Christoph Rademacher
The C-type lectin receptor Langerin is a glycan binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most of Langerin´s ligands are recognized via a canonical Ca2+-dependent binding site, interactions with heparins have been proposed to make additional contacts to a secondary, Ca2+-independent site. Glycan array screening and biomolecular NMR spectroscopy were employed to investigate the molecular mechanism of these interactions...
February 14, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28196094/innate-immunity-mediated-longevity-and-longevity-induced-by-germ-cell-removal-converge-on-the-c-type-lectin-domain-protein-irg-7
#7
Elad Yunger, Modi Safra, Mor Levi-Ferber, Anat Haviv-Chesner, Sivan Henis-Korenblit
In C. elegans, removal of the germline triggers molecular events in the neighboring intestine, which sends an anti-aging signal to the rest of the animal. In this study, we identified an innate immunity related gene, named irg-7, as a novel mediator of longevity in germlineless animals. We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28192256/response-of-gut-health-and-microbiota-to-sulfide-exposure-in-pacific-white-shrimp-litopenaeus-vannamei
#8
Yantong Suo, Erchao Li, Tongyu Li, Yongyi Jia, Jian G Qin, Zhimin Gu, Liqiao Chen
Sulfide is a natural and widely distributed toxicant. It can be commonly found on the interface between water and sediment in the aquatic environment. The Pacific white shrimp Litopenaeus vannamei starts life in the benthic zone soon after the mysis stage, an early stage of post larvae. Therefore, L. vannamei is inevitably affected by exposure to sulfide released from pond sediment. This study explored the toxicant effect of different concentrations of sulfide on the intestinal health and microbiota of Pacific white shrimp by monitoring the change of expression of inflammatory, immune related cytokines, and the structure of the intestinal microbiota...
February 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28192121/convulxin-a-c-type-lectin-like-protein-inhibits-hcasmcs-functions-via-wad-motif-integrin-%C3%AE-v-interaction-and-nf-%C3%AE%C2%BAb-independent-gene-suppression-of-gro-and-il-8
#9
Chun-Ho Shih, Tin-Bin Chiang, Wen-Jeng Wang
Convulxin (CVX), a C-type lectin-like protein (CLPs), is a potent platelet aggregation inducer. To evaluate its potential applications in angiogenic diseases, the multimeric CVX were further explored on its mode of actions toward human coronary artery smooth muscle cells (HCASMCs). The N-terminus of β-chain of CVX (CVX-β) contains a putative disintegrin-like domain with a conserved motif upon the sequence comparison with other CLPs. Importantly, native CVX had no cytotoxic activity as examined by electrophoretic pattern...
February 10, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28190635/langerhans-cells-the-yin-and-yang-of-hiv-restriction-and-transmission
#10
Luzia Mayr, Bin Su, Christiane Moog
Langerhans cells are specialized sentinels present in the epidermis expressing Langerin, a specific C-type lectin receptor involved in HIV capture and destruction. Recently, the specific mechanism leading to this HIV restriction was discovered. Nevertheless, Langerhans cells can be infected and the way HIV escapes this restriction needs to be unraveled.
February 9, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28188836/effect-of-bjcul-a-lectin-isolated-from-bothrops-jararacussu-on-human-peripheral-blood-mononuclear-cells
#11
Weverson Luciano Pires, Onassis Boeri de Castro, Anderson Makoto Kayano, Sulamita da Silva Setúbal, Adriana Silva Pontes, Neriane Monteiro Nery, Mauro Valentino Paloschi, Soraya Dos Santos Pereira, Rodrigo Guerino Stábeli, Carla Freire Celedônio Fernandes, Andreimar Martins Soares, Juliana Pavan Zuliani
BjcuL is a C-type lectin with specificity for the binding of β-d-galactose units isolated from Bothrops jararacussu venom. It triggers cellular infiltration in post capillary venules, increases edema and vascular permeability in murine models, contributes to in vitro neutrophil activation and modulates macrophage functional activation towards an M1 state. The purpose of this study was to investigate the effect of BjcuL on human peripheral blood mononuclear cells (PBMCs) activation with a focus on PBMCs proliferation and inflammatory mediators release...
February 8, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28180967/the-evolution-of-the-natural-killer-complex-a-comparison-between-mammals-using-new-high-quality-genome-assemblies-and-targeted-annotation
#12
John C Schwartz, Mark S Gibson, Dorothea Heimeier, Sergey Koren, Adam M Phillippy, Derek M Bickhart, Timothy P L Smith, Juan F Medrano, John A Hammond
Natural killer (NK) cells are a diverse population of lymphocytes with a range of biological roles including essential immune functions. NK cell diversity is in part created by the differential expression of cell surface receptors which modulate activation and function, including multiple subfamilies of C-type lectin receptors encoded within the NK complex (NKC). Little is known about the gene content of the NKC beyond rodent and primate lineages, other than it appears to be extremely variable between mammalian groups...
February 9, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28179943/synthesis-of-multi-lactose-appended-%C3%AE-cyclodextrin-and-its-cholesterol-lowering-effects-in-niemann-pick-type-c-disease-like-hepg2-cells
#13
Keiichi Motoyama, Rena Nishiyama, Yuki Maeda, Taishi Higashi, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Niemann-Pick type C (NPC) disease, characterized by intracellular accumulation of unesterified cholesterol and other lipids owing to defects in two proteins NPC1 and NPC2, causes neurodegeneration and other fatal neurovisceral symptoms. Currently, treatment of NPC involves the use of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). HP-β-CD is effective in the treatment of hepatosplenomegaly in NPC disease, albeit at a very high dose. One of the methods to reduce the required dose of HP-β-CD for treatment of NPC is to actively targeting hepatocytes with β-cyclodextrin (β-CD)...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28167651/contact-collaboration-and-conflict-signal-integration-of-syk-coupled-c-type-lectin-receptors
#14
REVIEW
Jenny Ostrop, Roland Lang
Several spleen tyrosine kinase-coupled C-type lectin receptors (CLRs) have emerged as important pattern recognition receptors for infectious danger. Because encounter with microbial pathogens leads to the simultaneous ligation of several CLRs and TLRs, the signals emanating from different pattern recognition receptors have to be integrated to achieve appropriate biological responses. In this review, we briefly summarize current knowledge about ligand recognition and core signaling by Syk-coupled CLRs. We then address mechanisms of synergistic and antagonistic crosstalk between different CLRs and with TLRs...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28167605/thymus-derived-treg-cell-development-is-regulated-by-c-type-lectin-mediated-bic-mirna155-expression
#15
Raquel Sánchez-Díaz, Rafael Blanco-Dominguez, Sandra Lasarte, Katerina Tsilingiri, Enrique Martín-Gayo, Beatriz Linillos-Pradillo, Hortensia de la Fuente, Francisco Sánchez-Madrid, Rinako Nakagawa, María L Toribio, Pilar Martín
Thymus-derived regulatory T cells (tTregs) are key to prevent autoimmune diseases but the mechanisms involved in their development remain unsolved. Here, we show that the C-type lectin receptor CD69 controls tTreg cell development and peripheral Treg homeostasis through the regulation of BIC/miR-155 and its target, the suppressor of cytokine signaling 1 (SOCS-1). Using Foxp3-mRFP/cd69(+/-) or/cd69(-/-) reporter mice, shRNA-mediated silencing and miR-155 transfection approaches, we found that CD69 deficiency impaired the signal transducer and activator of transcription 5 (STAT5) pathway in Foxp3(+) cells...
February 6, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28157429/chimeric-anti-human-podoplanin-antibody-nz-12-of-lambda-light-chain-exerts-higher-antibody-dependent-cellular-cytotoxicity-and-complement-dependent-cytotoxicity-compared-with-nz-8-of-kappa-light-chain
#16
Mika K Kaneko, Shinji Abe, Satoshi Ogasawara, Yuki Fujii, Shinji Yamada, Takeshi Murata, Hiroaki Uchida, Hideaki Tahara, Yasuhiko Nishioka, Yukinari Kato
Podoplanin (PDPN), a type I transmembrane 36-kDa glycoprotein, is expressed not only in normal cells, such as renal epithelial cells (podocytes), lymphatic endothelial cells, and pulmonary type I alveolar cells, but also in cancer cells, including brain tumors and lung squamous cell carcinomas. Podoplanin activates platelet aggregation by binding to C-type lectin-like receptor-2 (CLEC-2) on platelets, and the podoplanin/CLEC-2 interaction facilitates blood/lymphatic vessel separation. We previously produced neutralizing anti-human podoplanin monoclonal antibody (mAb), clone NZ-1 (rat IgG2a, lambda), which neutralizes the podoplanin/CLEC-2 interaction and inhibits platelet aggregation and cancer metastasis...
February 3, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28141595/the-role-of-mincle-in-innate-immune-to-fungal-keratitis
#17
Guiqiu Zhao, Qiang Xu, Jing Lin, Wenjun Chen, Tingting Cui, Liting Hu, Nan Jiang
INTRODUCTION: This study aimed to detect the early expression of macrophage-inducible C-type lectin (Mincle) and investigate its role in the innate immune response of fungal keratitis (FK). METHODOLOGY: Wistar rats were used to make fungal keratitis models. The inflammatory responses and corneal lesions were observed by slit-lamp microscope.RT-PCR, immunohistochemistry, and immunofluorescence were used to detect the expression of Mincle in the rat corneal epithelium...
January 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28130154/what-killed-karl-patterson-schmidt-combined-venom-gland-transcriptomic-venomic-and-antivenomic-analysis-of-the-south-african-green-tree-snake-the-boomslang-dispholidus-typus
#18
Davinia Pla, Libia Sanz, Gareth Whiteley, Simon C Wagstaff, Robert A Harrison, Nicholas R Casewell, Juan J Calvete
BACKGROUND: Non-front-fanged colubroid snakes comprise about two-thirds of extant ophidian species. The medical significance of the majority of these snakes is unknown, but at least five species have caused life-threatening or fatal human envenomings. However, the venoms of only a small number of species have been explored. METHODS: A combined venomic and venom gland transcriptomic approach was employed to characterise of venom of Dispholidus typus (boomslang), the snake that caused the tragic death of Professor Karl Patterson Schmidt...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28128492/beyond-attachment-roles-of-dc-sign-in-dengue-virus-infection
#19
Ping Liu, Marc Ridilla, Pratik Patel, Laurie Betts, Emily Gallichotte, Lidea Shahidi, Nancy L Thompson, Ken Jacobson
DC-SIGN, a C-type lectin expressed on the plasma membrane by human immature dendritic cells, is a receptor for numerous viruses including Ebola, SARS, and dengue. A controversial question has been whether DC-SIGN functions as a complete receptor for both binding and internalization of dengue virus (DENV) or whether it is solely a cell surface attachment factor, requiring either hand-off to another receptor or a co-receptor for internalization. To examine this question, we used four cell types: human immature dendritic cells and NIH3T3 cells expressing either wild type DC-SIGN or two internalization-deficient DC-SIGN mutants, in which either the three cytoplasmic internalization motifs are silenced by alanine substitutions or the cytoplasmic region is truncated...
January 27, 2017: Traffic
https://www.readbyqxmd.com/read/28127756/absence-of-dcir1-reduces-the-mortality-rate-of-endotoxemic-hepatitis-in-mice
#20
Toshifumi Ishiguro, Testuya Fukawa, Kotaro Akaki, Koji Nagaoka, Tatsuki Takeda, Yoichiro Iwakura, Kayo Inaba, Kazuhiko Takahara
Dendritic cell immunoreceptor (DCIR) is a C-type lectin with an immunoreceptor tyrosine-based inhibitory motif (ITIM). Mice lacking DCIR1 (Dcir1(-/-) mice) show higher susceptibility to chronic arthritis with increasing age, suggesting that DCIR1 is involved in immune modulation via its ITIM. However, the role of DCIR1 in acute immune responses is not clear. In this study, we explored its role in acute experimental hepatitis. Upon injection of d-galactosamine and lipopolysaccharide, Dcir1(-/-) mice showed decreased mortality rates and serum levels of alanine aminotransferase (ALT)...
January 26, 2017: European Journal of Immunology
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