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C-type lectin

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https://www.readbyqxmd.com/read/29210476/delayed-revascularization-of-islets-after-transplantation-by-il-6-blockade-in-pig-to-non-human-primate-islet-xenotransplantation-model
#1
Byoung-Hoon Min, Jun-Seop Shin, Jong-Min Kim, Seong-Jun Kang, Hyun-Je Kim, Il-Hee Yoon, Su-Kyoung Park, Ji-Won Choi, Min-Suk Lee, Chung-Gyu Park
BACKGROUND: Pancreatic islet transplantation is currently proven as a promising treatment for type 1 diabetes patients with labile glycemic control and severe hypoglycemia unawareness. Upon islet transplantation, revascularization is essential for proper functioning of the transplanted islets. As IL-6 is important for endothelial cell survival and systemic inflammation related to xenograft, the effect of IL-6 receptor antagonist, tocilizumab, on revascularization of the transplanted islets was examined in pig to non-human primate islet xenotransplantation model...
December 6, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/29208955/the-interdomain-flexible-linker-of-the-polypeptide-galnac-transferases-dictates-their-long-range-glycosylation-preferences
#2
Matilde de Las Rivas, Erandi Lira-Navarrete, Earnest James Paul Daniel, Ismael Compañón, Helena Coelho, Ana Diniz, Jesús Jiménez-Barbero, Jesús M Peregrina, Henrik Clausen, Francisco Corzana, Filipa Marcelo, Gonzalo Jiménez-Osés, Thomas A Gerken, Ramon Hurtado-Guerrero
The polypeptide GalNAc-transferases (GalNAc-Ts), that initiate mucin-type O-glycosylation, consist of a catalytic and a lectin domain connected by a flexible linker. In addition to recognizing polypeptide sequence, the GalNAc-Ts exhibit unique long-range N- and/or C-terminal prior glycosylation (GalNAc-O-Ser/Thr) preferences modulated by the lectin domain. Here we report studies on GalNAc-T4 that reveal the origins of its unique N-terminal long-range glycopeptide specificity, which is the opposite of GalNAc-T2...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29208681/hemitam-a-single-tyrosine-motif-that-packs-a-punch
#3
REVIEW
Björn Bauer, Alexander Steinle
Innate immune cells sense danger through a plethora of germline-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs) or cellular molecules that are exposed only by stressed, infected, malignant, or dead cells. Many of these danger-sensing receptors belong to the C-type lectin-like superfamily (CLSF) and therefore are called C-type lectin-like receptors (CTLRs). Certain activating CTLRs, namely, CLEC-2, Dectin-1, DNGR-1, NKp80, and NKp65, which are encoded by genes that are clustered together in a subregion of the mammalian natural killer gene complex (NKC), use a single copy tyrosine signaling module termed the hemi-immunoreceptor tyrosine-based activation motif (hemITAM)...
December 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/29207919/enhancement-of-natural-killer-activity-and-ifn-%C3%AE-production-in-an-il-12-dependent-manner-by-a-brassica-rapa-l
#4
Kana Yamamoto, Kanon Furuya, Kazuki Yamada, Fuka Takahashi, Chisato Hamajima, Sachi Tanaka
Certain food components possess immunomodulatory effects. The aim of this study was to elucidate the mechanism of the immunostimulatory activity of Brassica rapa L. We demonstrated an enhancement of natural killer (NK) activity and interferon (IFN)-γ production in mice that were orally administered an insoluble fraction of B. rapa L. The insoluble fraction of B. rapa L. significantly induced IFN-γ production in mouse spleen cells in an interleukin (IL)-12-dependent manner, and NK1.1+ cells were the main cells responsible for producing IFN-γ...
December 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29198776/insect-c-type-lectins-in-innate-immunity
#5
Xiaofeng Xia, Minsheng You, Xiang-Jun Rao, Xiao-Qiang Yu
C-type lectins (CTLs) are a family of proteins that contain characteristic modules of carbohydrate-recognition domains (CRDs) and they possess the binding activity to ligands in a calcium-dependent manner. CTLs play important roles in animal immune responses, and in insects, they are involved in opsonization, nodule formation, agglutination, encapsulation, melanization, and prophenoloxidase activation, as well as in maintaining gut microbiome homeostasis. In this review, we will summarize insect CTLs, compare the properties of insect CTLs with vertebrate CTLs, and focus mainly on the domain organization and functions of insect CTLs in innate immunity...
November 30, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29196192/macrovipecetin-a-c-type-lectin-from-macrovipera-lebetina-venom-inhibits-proliferation-migration-and-invasion-of-sk-mel-28-human-melanoma-cells-and-enhances-their-sensitivity-to-cisplatin
#6
Manel B Hammouda, Ichrak Riahi-Chebbi, Soumaya Souid, Houcemeddine Othman, Zohra Aloui, Najet Srairi-Abid, Habib Karoui, Ammar Gasmi, Edith M Magnenat, Timothy N C Wells, Kenneth J Clemetson, José Neptuno Rodríguez-López, Khadija Essafi-Benkhadir
BACKGROUND: The resistance of melanoma cells to cisplatin restricts its clinical use. Therefore, the search for novel tumor inhibitors and effective combination treatments that sensitize tumor cells to this drug are still needed. We purified macrovipecetin, a novel heterodimeric C-type lectin, from Macrovipera lebetina snake venom and investigated its anti-tumoral effect on its own or combined with cisplatin, in human melanoma cells. METHODS: Biochemical characterization, in vitro cells assays such as viability, apoptosis, adhesion, migration, invasion, Western blotting and in silico analysis were used in this study...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29189742/targeting-metastasis-with-snake-toxins-molecular-mechanisms
#7
REVIEW
Félix A Urra, Ramiro Araya-Maturana
Metastasis involves the migration of cancer cells from a primary tumor to invade and establish secondary tumors in distant organs, and it is the main cause for cancer-related deaths. Currently, the conventional cytostatic drugs target the proliferation of malignant cells, being ineffective in metastatic disease. This highlights the need to find new anti-metastatic drugs. Toxins isolated from snake venoms are a natural source of potentially useful molecular scaffolds to obtain agents with anti-migratory and anti-invasive effects in cancer cells...
November 30, 2017: Toxins
https://www.readbyqxmd.com/read/29187378/platelet-glycoprotein-vi-aids-in-local-immunity-during-gram-negative-pneumonia-derived-sepsis
#8
Theodora A M Claushuis, Alex F de Vos, Bernhard Nieswandt, Louis Boon, Joris J T H Roelofs, Onno J de Boer, Cornelis J van 't Veer, Tom van der Poll
Platelet collagen receptor glycoprotein(GP)VI and podoplanin receptor C-type lectin-like receptor (CLEC-)2 are receptors implicated in platelet activation that both signal via an immunoreceptor-tyrosine-based activation motif. Platelets are necessary for host defense and prevention of hemorrhage during sepsis, but the role of platelet GPVI and CLEC2 herein is unknown. To investigate this we infected mice depleted of platelet GPVI or CLEC2 by antibody treatment or GPVI-/- mice with the common human sepsis pathogen Klebsiella pneumoniae via the airways to induce pneumonia derived sepsis...
November 29, 2017: Blood
https://www.readbyqxmd.com/read/29177670/molecular-chaperone-receptors
#9
Ayesha Murshid, Jimmy Theriault, Jianlin Gong, Stuart K Calderwood
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Using this approach we have discovered that Hsp70 binds avidly to at least two classes of receptors including: (1) c-type lectin receptors (CLR) and (2) scavenger receptors (SR)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29175707/using-the-glycan-toolbox-for-pathogenic-interventions-and-glycan-immunotherapy
#10
REVIEW
Rj Eveline Li, Sandra J van Vliet, Y van Kooyk
Glycans play a crucial role to discern between self and foreign entities by providing key recognition elements for C-type lectin receptors (CLRs) and Siglec receptors expressed on immune cells. The glycan recognition of CLRs has illustrated a potent immune modulatory role affecting not only innate pathogen binding and immune signalling, but also Thelper differentiation, cytokine production and antigen presentation. This broad range of influence has implicated glycans in the pathogenesis of infectious diseases but also revealed their extraordinary properties in cancer...
November 22, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29174415/neuroinflammation-induced-by-amyloid-%C3%AE-25-35-modifies-mucin-type-o-glycosylation-in-the-rat-s-hippocampus
#11
Ivan Ramos-Martinez, Pamela Martínez-Loustalot, Liliana Lozano, Tarik Issad, Daniel Limón, Alfonso Díaz, Armando Perez-Torres, Jorge Guevara, Edgar Zenteno
Amyloid-β (Aβ) plays a relevant role in the neurodegenerative process of Alzheimer's disease (AD). The 25-35 peptide of amyloid-β (Aβ25-35) induces the inflammatory response in brain experimental models. Mucin-type O-glycosylation has been associated with inflammation of brain tissues in AD, thus in this work, we aimed at identifying changes in the glycosylation profile generated by the injection of Aβ25-35 into the CA1 of the hippocampus of rats, using histochemistry with lectins. Our results indicate that 100μM Aβ25-35 induce increased recognition of the Amaranthus leucocarpus lectin (ALL) (specific for Galβ1,3-GalNAcα1,0-Ser/Thr); whereas concanavalin A (Con A) (specific for α-Man) showed no differences among treated and control groups of rats...
November 21, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29169147/c-type-lectin-receptors-in-anti-fungal-immunity
#12
REVIEW
Moe Shiokawa, Sho Yamasaki, Shinobu Saijo
Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems. Upon ligand binding, CLRs stimulate cellular responses by inducing the production of cytokines and reactive oxygen species via the Syk/CARD9 signaling pathway, leading to fungal elimination...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29164671/characterization-of-two-groups-of-spodoptera-exigua-h%C3%A3-bner-lepidoptera-noctuidae-c-type-lectins-and-insights-into-their-role-in-defense-against-the-densovirus-jcdv
#13
Laila Gasmi, Agata K Jakubowska, Juan Ferré, Mylène Ogliastro, Salvador Herrero
Insect innate immunity relies on numerous soluble and membrane-bound receptors, named pattern recognition proteins (PRPs), which enable the insect to recognize pathogen-associated molecular patterns. C-type lectins are among the best-studied PRPs and constitute the most diverse family of animal lectins. Here we have characterized two groups of Spodoptera exigua C-type lectins that differ in their phylogeny, domain architecture, and expression pattern. One group includes C-type lectins with similar characteristics to other lepidopteran lectins, and a second group includes bracoviral-related lectins (bracovirus-like lectins, Se-BLLs) recently acquired by horizontal gene transfer...
November 22, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29163499/fc%C3%AE%C2%B5ri-%C3%AE-chain-negatively-modulates-dectin-1-responses-in-dendritic-cells
#14
Yi-Gen Pan, Yen-Ling Yu, Chi-Chien Lin, Lewis L Lanier, Ching-Liang Chu
The inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcεRI γ-chain (FcRγ) has been found in many immune functions. Herein, we have further explored the role of these adapters in C-type lectin receptors response. We identified that FcRγ, but not DAP12, could negatively regulate the Dectin-1 responses in dendritic cells (DCs). Loss of FcRγ or both DAP12 and FcRγ enhanced the maturation and cytokine production in DCs upon Dectin-1 activation compared to normal cells, whereas DCs lacking only DAP12 showed little changes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29161183/epitope-mapping-of-monoclonal-antibody-pmab-38-against-dog-podoplanin
#15
Yao-Wen Chang, Shinji Yamada, Mika K Kaneko, Yukinari Kato
Podoplanin (PDPN), a type I transmembrane sialoglycoprotein, is extensively expressed by normal lymphatic endothelial cells, renal podocytes, and pulmonary type I alveolar cells. Nevertheless, increased expression of PDPN in malignant tumors not only associates with poor prognosis but also facilitates hematogenous metastasis through interaction with C-type lectin-like receptor-2 presented on platelets, followed by PDPN-mediated platelet activation. We previously reported a novel PMab-38 antibody, an anti-dog PDPN (dPDPN) monoclonal antibody, which specifically recognizes PDPN in squamous cell carcinomas melanomas and cancer-associated fibroblasts in canine cancer tissues...
November 21, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29154855/identification-and-characterization-of-a-calcium-dependent-lily-type-lectin-from-black-rockfish-sebastes-schlegelii-molecular-antennas-are-involved-in-host-defense-via-pathogen-recognition
#16
Roopasingam Kugapreethan, Qiang Wan, Jehanathan Nilojan, Jehee Lee
Lily-type lectins (LTLs) are soluble pathogen recognition receptors (PRRs) that contain one or more characteristic carbohydrate recognition domains (CRDs), through which LTLs bind reversibly and specifically to cognate sugar moieties present on the invading pathogen membrane and trigger the host innate immune responses. In this study, we identified a LTL homolog (SsLTL) from black rockfish (Sebastes schlegelii) transcriptome database and its functional roles in innate immunity was investigated in vitro and in vivo...
November 14, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29147524/manipulation-of-cytokine-secretion-in-human-dendritic-cells-using-glycopolymers-with-picomolar-affinity-for-dc-sign
#17
Daniel A Mitchell, Qiang Zhang, Lenny Voorhaar, David M Haddleton, Shan Herath, Anne S Gleinich, Harpal S Randeva, Max Crispin, Hendrik Lehnert, Russell Wallis, Steven Patterson, C Remzi Becer
The human C-type lectin DC-SIGN (CD209) is a significant receptor on the surface of dendritic cells (DCs) - crucial components of host defense that bridge the innate and adaptive immune systems. A range of linear glycopolymers, constructed via controlled radical polymerization techniques have been shown to interact with DC-SIGN with affinities in the physiologically active range. However, these first generation glycopolymers possess limited structural definition and their effects on DCs were not known. Here we report the development of star-shaped mannose glycopolymers with the aim of targeting the clustered domain arrangement of DC-SIGN and these were shown to bind with picomolar affinity...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29146750/trpm7-transient-receptor-potential-melastatin-like-7-channel-kinase-controls-calcium-responses-in-arterial-thrombosis-and-stroke-in-mice
#18
Sanjeev K Gotru, Wenchun Chen, Peter Kraft, Isabelle C Becker, Karen Wolf, Simon Stritt, Susanna Zierler, Heike M Hermanns, Deviyani Rao, Anne-Laure Perraud, Carsten Schmitz, René P Zahedi, Peter J Noy, Michael G Tomlinson, Thomas Dandekar, Masayuki Matsushita, Vladimir Chubanov, Thomas Gudermann, Guido Stoll, Bernhard Nieswandt, Attila Braun
OBJECTIVE: TRPM7 (transient receptor potential melastatin-like 7 channel) is a ubiquitously expressed bifunctional protein comprising a transient receptor potential channel segment linked to a cytosolic α-type serine/threonine protein kinase domain. TRPM7 forms a constitutively active Mg(2+) and Ca(2+) permeable channel, which regulates diverse cellular processes in both healthy and diseased conditions, but the physiological role of TRPM7 kinase remains largely unknown. APPROACH AND RESULTS: Here we show that point mutation in TRPM7 kinase domain deleting the kinase activity in mice (Trpm7(R/R) ) causes a marked signaling defect in platelets...
November 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29146595/the-cartilage-specific-lectin-c-type-lectin-domain-family-3-member-a-clec3a-enhances-tissue-plasminogen-activator-mediated-plasminogen-activation
#19
Daniela Lau, Dzemal Elezagic, Gabriele Hermes, Matthias Mörgelin, Alexander P Wohl, Manuel Koch, Ursula Hartmann, Stefan Höllriegl, Raimund Wagener, Mats Paulsson, Thomas Streichert, Andreas R Klatt
C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Its closest homologue tetranectin binds to the kringle 4 domain of plasminogen and enhances its association with tissue plasminogen activator (tPA) thereby enhancing plasmin production, but whether CLEC3A contributes to plasminogen activation is unknown. Here, we recombinantly expressed murine and human full-length CLEC3As as well as truncated forms of CLEC3A in HEK-293 EBNA cells...
November 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29142050/collectin-11-promotes-the-development-of-renal-tubulointerstitial-fibrosis
#20
Weiju Wu, Chengfei Liu, Conrad A Farrar, Liang Ma, Xia Dong, Steven H Sacks, Ke Li, Wuding Zhou
Collectin-11 is a recently described soluble C-type lectin, a pattern recognition molecule of the innate immune system that has distinct roles in host defense, embryonic development, and acute inflammation. However, little is known regarding the role of collectin-11 in tissue fibrosis. Here, we investigated collectin-11 in the context of renal ischemia-reperfusion injury. Compared with wild-type littermate controls, Collec11 deficient (CL-11-/- ) mice had significantly reduced renal functional impairment, tubular injury, renal leukocyte infiltration, renal tissue inflammation/fibrogenesis, and collagen deposition in the kidneys after renal ischemia-reperfusion injury...
November 15, 2017: Journal of the American Society of Nephrology: JASN
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