keyword
https://read.qxmd.com/read/38292818/associated-factors-and-outcomes-of-acute-kidney-injury-in-covid-19-patients-in-kenya
#21
JOURNAL ARTICLE
Susan Cheruiyot, Jacob Shabani, Jasmit Shah, Catherine Gathu, Ahmed Sokwala
BACKGROUND: Corona Virus Disease 2019 (COVID-19), an infection caused by the SARS-CoV-2 virus, has been the largest global pandemic since the turn of the 21st century. With emerging research on this novel virus, studies from the African continent have been few. Corona Virus Disease 2019 has been shown to affect various organs including the lungs, gut, nervous system, and the kidneys. Acute kidney injury (AKI) is an independent risk factor for mortality and increases the health care burden for patients with persistent kidney dysfunction and maintenance dialysis...
2024: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/38285637/applying-the-principles-for-digital-development-to-improve-maternal-and-child-health-in-the-peri-urban-areas-of-karachi-pakistan
#22
JOURNAL ARTICLE
Hareem Ahmer, Kinza Farooqui, Karim Jivani, Rehan Adamjee, Zahra Hoodbhoy
Low- middle-income countries, including Pakistan, are facing significant obstacles in their efforts to achieve the global targets for maternal, newborn, and child health (MNCH) defined by the Sustainable Development Goals. Barriers at the individual, health system, and contextual levels undermine healthcare access for pregnant women and children, disproportionately affecting those in low-resource settings. To address these challenges in the high-mortality, peri-urban areas of Karachi, VITAL Pakistan Trust and Aga Khan University launched a digital health intervention (DHI) to stimulate demand for health services and streamline care management for health workers at the primary care level...
January 2024: PLOS Digit Health
https://read.qxmd.com/read/38267078/regulatory-approval-of-clinical-trials-is-it-time-to-reinvent-the-wheel
#23
JOURNAL ARTICLE
Mansoor Saleh, Karishma Sharma, Aisleen Shamshudin, Innocent Obayo, Stacey Gondi, Noureen Karimi
Less than 1% of all clinical trials are conducted in Africa. In 2019, only six of 26 oncology clinical trials conducted in Africa were conducted in countries with subjects of African ancestry. There are multiple barriers that hinder the conduct of cancer clinical trials in Africa. Time to trial activation (TTA) is the administrative and regulatory process required before a study can be activated-an important metric and often a major barrier for site selection. In Kenya, TTA involves review by Institutional Review Board (IRB), Pharmacy and Poisons Board, National Commission for Science, Technology and Innovation and Ministry of Health, all in a sequential fashion...
January 24, 2024: BMJ Global Health
https://read.qxmd.com/read/38241337/unveiling-the-silent-threat-of-new-onset-atrial-fibrillation-in-covid-19-hospitalized-patients-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Muhammad Shakir, Syed Muhammad Hassan, Ursala Adil, Syed Muhammad Aqeel Abidi, Syed Ahsan Ali
BACKGROUND: COVID-19, a highly infectious respiratory disease, has been associated with a range of cardiovascular complications. One of the most commonly reported cardiovascular issues in COVID-19 patients is the development of arrhythmias. Among all types of arrhythmias, atrial fibrillation is the most frequently observed. Atrial fibrillation is characterized by an irregular and often rapid heartbeat, and it can be a serious and potentially life-threatening condition. OBJECTIVE: To investigate the incidence and association of new onset atrial fibrillation in COVID-19 hospitalized patients and its impact on survival...
2024: PloS One
https://read.qxmd.com/read/38219163/pulmonary-barotrauma-as-a-complication-of-mechanical-ventilation-for-management-of-covid-19-associated-acute-respiratory-distress-syndrome-cards
#25
JOURNAL ARTICLE
Shahmeer Khan, Kiran Hilal, Ainan Fayyaz Arshad, Avinash Nankani, Syeda Zoha Zehra Rizvi, Tanveer Ul Haq
OBJECTIVES: To identify that incidence of pulmonary barotrauma secondary to mechanical ventilation for the management of acute respiratory distress syndrome associated with coronavirus-disease-2019, and to compare it with the incidence of pulmonary barotrauma trauma secondary to mechanical ventilation associated with all the other causes. METHODS: The retrospective case-control study was conducted at the Aga Khan University Hospital, Karachi, and comprised data from October 2020 to March 2021 of patients who underwent mechanical ventilation...
January 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38196489/-illicium-verum-anticancer-activity-against-mda-mb-231-cell-line
#26
JOURNAL ARTICLE
Asra Khan Pahore, Shagufta Khan, Nasim Karim
OBJECTIVE: To evaluate the anticancer activity of methanolic extract of Illicium verum against triple-negative breast cancer MDA-MB-231 cell line. METHODS: A cell culture experimental study was carried out at Pharmacology department of Bahria University Medical and Dental College (January to June 2021) in collaboration with Aga Khan University, Karachi, Pakistan. Cell viability and proliferation assays were used to quantify dead and alive cells by utilizing a tetrazolium assay and an enzyme immunosorbent plate reader was used to calculate their absorbance...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38196485/comparison-of-pre-and-post-foley-catheter-bishop-s-score-a-retrospective-record-review-at-aga-khan-university-hospital-karachi-pakistan
#27
JOURNAL ARTICLE
Ayesha Malik, Sheikh Irfan, Farheen Yousuf, Azra Amerjee, Sumaira Naz, Safna Virji
OBJECTIVE: To compare pre and post Foley's catheter Bishop Score during labour induction. METHODS: This study was a retrospective study conducted at the Aga Khan University Hospital Karachi, Pakistan after approval from ethical review board. All women who underwent induction of labour with Foley's Catheter at gestation of 37 weeks or more from September 2014-October 2015 were included. Data was entered and analyzed in Statistical Package for Social Sciences (SPSS) version 19...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38196479/recurrence-of-portosystemic-encephalopathy-in-cirrhotic-patients-and-its-risk-factors
#28
JOURNAL ARTICLE
Masood Muhammad Karim, Abdullah Bin Khalid, Zahabia Sohail, Mohammad Yasrab
OBJECTIVES: Recurrent episodes of Portal Systemic Encephalopathy (PSE), poses a significant burden of illness on the patients and healthcare system. The objective of this study was to assess the recurrence of PSE in cirrhotic patients after index episode of PSE and to identify various risk factors associated with it. METHODS: A retrospective, single-centre study was conducted at Aga Khan University Hospital over a span of one year. Patients who were admitted first time with PSE and admitted within three months of index PSE were enrolled in the study...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38196478/outcomes-of-oncoplastic-breast-surgery-compared-to-breast-conserving-surgery-in-breast-cancer-patients-in-a-developing-country-a-retrospective-cohort-study
#29
JOURNAL ARTICLE
Lubna M Vohra, Nifasat Farooqi, Uswa Jiwani, Danish Ali
BACKGROUND AND OBJECTIVE: Breast-conserving surgery (BCS) with adjuvant radiotherapy remains the standard of care for early breast cancers in Pakistan. We sought to compare the outcomes of BCS with oncoplastic surgery (OPS), a relatively infrequent approach to breast cancer treatment in the country. METHODS: This retrospective cohort study was conducted at Aga Khan University Hospital and Ziauddin Hospital in Karachi. Patients who had biopsy-proven Stage-I to III breast cancer and underwent either OPS or BCS between August 1, 2016, and December 31, 2021, were identified and followed for 30 days...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38186542/association-between-the-site-of-infection-and-mortality-analysis-in-critically-ill-surgical-patients
#30
JOURNAL ARTICLE
Waleed Bin Ghaffar, Sidra Nazir, Summiya Siddiqui, Moeed B Abdul Ghaffar, Muhammad F Khan, Asad Latif, Zahra Cheema, Sadaf Hanif, Mohammad Sohaib
Background Sepsis remains a critical global health concern, leading to a high mortality rate. Existing literature suggests a potential correlation between infection site and mortality. Mortality data from Pakistan, especially in the context of the infection site, is notably scarce. Purpose The study aimed to explore the relationship between the site of infection and clinical features in deceased septic patients in the surgical intensive care unit. Methods In this retrospective study conducted at the Aga Khan University Hospital, data from patients admitted to the surgical intensive care unit and meeting Sepsis 3 criteria over a five-year period (2016-2020) were analyzed...
December 2023: Curēus
https://read.qxmd.com/read/38185971/short-term-outcomes-of-elective-abdominal-aortic-aneurysm-repair
#31
JOURNAL ARTICLE
Zia Ur Rehman, Hafsa Shaikh, Ziad Sophie
OBJECTIVE: To evaluate the presentations, aetiologies, and outcomes (survival and morbidity) of patients who underwent abdominal aortic aneurysm (AAA) repair at a tertiary care centre in a low middle-income country (LMIC). STUDY DESIGN: Case-series study. Place and Duration of the Study: Section of Vascular Surgery, Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan, from January 2000 till April 2022. METHODOLOGY: All patients who underwent elective open repair for AAA were identified using ICD coding 10...
January 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38185956/daptomycin-mics-by-broth-microdilution-method-against-em-staphylococcus-aureus-em-in-clinical-specimens-a-cross-sectional-study-from-pakistan
#32
JOURNAL ARTICLE
Mohammad Zeeshan, Imran Ahmed, Seema Irfan, Moiz Ahmed Khan, Afia Zafar
OBJECTIVE: To explore the distribution of daptomycin (DAP) minimum inhibitory concentrations (MICs) in Staphylococcus aureus isolated from complicated skin, soft tissue, and bloodstream infections collected from the Pakistani population using broth microdilution (BMD). STUDY DESIGN: Descriptive, cross-sectional study. Place and Duration of the Study: Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, from May to October 2021. METHODOLOGY: Through consecutive sampling techniques, 169 Staphylococcus aureus (S...
January 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38178007/prediction-of-major-adverse-cardiac-events-in-the-emergency-department-using-an-artificial-neural-network-with-a-systematic-grid-search
#33
JOURNAL ARTICLE
Ahmed Raheem, Shahan Waheed, Musa Karim, Nadeem Ullah Khan, Rida Jawed
BACKGROUND: The aim of our research was to design and evaluate an Artificial Neural Network (ANN) model using a systemic grid search for the early prediction of major adverse cardiac events (MACE) among patients presenting to the triage of an emergency department. METHODS: This is a single-center, cross-sectional study using electronic health records from January 2017 to December 2020. The research population consists of adults coming to our emergency department triage at Aga Khan University Hospital...
January 4, 2024: International Journal of Emergency Medicine
https://read.qxmd.com/read/38177278/evaluating-the-effect-of-maternal-non-communicable-disease-on-adverse-pregnancy-outcomes-and-birthweight-in-pakistan-a-facility-based-retrospective-cohort-study
#34
JOURNAL ARTICLE
Esther Wainwright, Irfan Sheikh, Rahat Qureshi, Sana Yousuf, Raheela Khan, Matthew Elmes
Non-communicable diseases (NCDs) claim 74% of global lives, disproportionately affecting lower and middle-income countries like Pakistan. NCDs may increase the risk of preterm birth (PTB), caesarean section (CS), and low birthweight. This study aims to determine whether the high prevalence of NCDs in Pakistan play a role in the high rates of preterm births, and CS. This retrospective cohort study from Aga Khan University Hospital, Pakistan, investigated effects of pre-existing NCDs on pregnancy outcomes of 817 pregnant women...
January 5, 2024: Scientific Reports
https://read.qxmd.com/read/38164127/fungal-empyema-thoracis-a-rare-but-an-emerging-entity-a-retrospective-case-series-from-pakistan
#35
JOURNAL ARTICLE
Nousheen Iqbal, Akbar Shoukat Ali, Aqusa Zahid, Kausar Jabeen, Muhammad Irfan
BACKGROUND AND OBJECTIVE: Fungal empyema is a rare entity which is associated with high mortality. It is mostly seen in immune-compromised hosts. However, there is limited data available on fungal empyema from developing countries regarding risk factors, treatment, and outcome. This study was conducted to determine the risk factors, clinical features, treatment, and outcome of fungal empyema. METHODS: A retrospective observational study was performed on proven fungal empyema cases, admitted at Aga Khan University Hospital, Karachi, Pakistan during January 2018 to May 2021...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38143724/the-impact-of-short-intensive-care-rotation-on-residents-experience-in-the-covid-19-pandemic-a-mixed-methods-study
#36
JOURNAL ARTICLE
Muhammad F Khan, Ayesha Aziz, Qamar Riaz, Waleed B Ghaffar, Fiza Khan, Asad Latif
OBJECTIVES: To assess the impact and utility of an intensive care unit (ICU) rotation during the coronavirus disease 2019 (COVID-19) pandemic and the need for mandatory ICU rotations in training for all clinical specialties. METHODS: A mixed methods study was conducted from January to September 2021 at the Aga Khan University Hospital, including resident doctors who rotated through COVID ICU between May and September 2020. An online survey was undertaken, followed by two focused group discussions (FGDs)...
2023: Journal of Medical Education and Curricular Development
https://read.qxmd.com/read/38112637/allergic-bronchopulmonary-aspergillosis-radiological-and-microbiological-profile-of-patients-presented-in-an-outpatient-pulmonary-clinic-in-a-developing-country
#37
JOURNAL ARTICLE
Nousheen Iqbal, Muhammad Irfan, Mustafa Bin Ali Zubairi, Maaha Ayub, Safia Awan, Kausar Jabeen, Ali Bin Sarwar Zubairi
There is limited data available about allergic bronchopulmonary aspergillosis (ABPA) in Pakistan. The aim of the study was to describe the radiological and microbiological profile of ABPA patients presenting to the outpatient pulmonary clinic of a tertiary care hospital in Karachi, Pakistan. A retrospective study was conducted on ABPA patients who presented to the pulmonary outpatient clinic at Aga Khan University Hospital, Karachi, Pakistan, from January 2017 to December 2019. Data was collected on microbiology and radiology features on predesigned proforma...
December 7, 2023: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38083925/factors-associated-with-medical-students-career-choices-at-a-private-university-a-cross-sectional-study
#38
JOURNAL ARTICLE
Sana Saeed, Mahanoor Raza, Areeba Hussain, Muhammad Maisam Ali, Farah Khalid
This study aimed to identify the factors associated with students' career choices and the decision whether they wanted to be trained abroad or in Pakistan. The study utilised a cross-sectional design and was conducted between July 2021 and February 2022. An anonymous survey was distributed among the medical students at Aga Khan University, Karachi, Pakistan. All analysis was carried out using Stata 17. A total of 269 students participated in the study. The most sought-after specialties were surgery 68 (25.3%), medicine 25(9...
December 2023: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38073931/sleep-pattern-changes-in-patients-who-are-scheduled-for-cardiac-surgery
#39
JOURNAL ARTICLE
Syed Shabbir Ahmed, Mohammad Hamid, Muhammad S Yousuf, Saqiba Tahir
Introduction Surgery patients frequently experience sleep deprivation, which is regarded as a stress factor during the perioperative period and can cause physical discomfort, exhaustion, and even postoperative pain. There is a dearth of information on preoperative sleep habits and the consequences that may result. There are both subjective and objective ways to rate the quality of your sleep. We chose the Pittsburgh Sleep Quality Index (PSQI), which employs a questionnaire to provide crucial information on issues like sleep length, efficiency, and interruption...
November 2023: Curēus
https://read.qxmd.com/read/38062588/comparison-of-clinical-outcomes-of-calcified-and-non-calcified-coronary-artery-lesion-intervention-under-ivus-guidance
#40
JOURNAL ARTICLE
Muhammad Nasir Rahman, Aiysha Nasir, Ihsan Ullah, Ghufran Adnan, Awais Farhad, Maria Ali Khan
OBJECTIVE: To evaluate the clinical results of intravascular ultrasound (IVUS)-guided intervention for calcified coronary artery lesions. STUDY DESIGN: Observational study. Place and Duration of the Study: Department of Medicine, The Aga Khan University Hospital, Karachi, from January 2013 to January 2020. METHODOLOGY: A cohort of 134 consecutive patients who underwent intravascular ultrasonography-guided assessment of coronary arteries were included...
December 2023: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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