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Aga Khan University

Arham Zavery, Faisal Qureshi, Arbaz Riaz, Fatima Pervez, Nousheen Iqbal, Javaid A Khan
The aim of the study was to determine the prevalence of shisha smoking; its associated factors and awareness among medical students of Karachi, Pakistan following the imposition of nationwide shisha ban. A cross sectional study was conducted among medical students of two medical universities, namely Sindh Medical College and Aga Khan University Karachi, Pakistan from October till December 2014. A total of 422 participants were included. Data was collected via a self-administered questionnaire. The mean age was 21 ± 1...
October 17, 2016: Journal of Community Health
Anish Khalil, Muhammad Faheem, Ammad Fahim, Haran Innocent, Zainab Mansoor, Shehrbano Rizvi, Hizra Farrukh
Background. The biomedical care for cancer has not been complemented by psychosocial progressions in cancer care. Objectives. To find the prevalence of anxiety and depression amongst cancer patients in a hospital setting. Design and Setting. This cross-sectional study was conducted at the tertiary care hospitals Shifa International Hospital Islamabad and Nuclear Medicine, Oncology, and Radiotherapy Institute [NORI]. Patients and Methods. 300 patients were interviewed from both the outpatient and inpatient department using The Aga Khan University Anxiety and Depression Scale (AKUADS)...
2016: Psychiatry Journal
Zehra Parveen, Arif Ali, Tahira Mohsin Ali, Abid Hasnain
OBJECTIVE: To identify major dietary patterns and examine their association with anthropometric, lifestyle and socio-economic factors among women belonging to different communities living in Karachi. METHODS: This cross-sectional study was conducted in Karachi from June 2014 to August 2015, and comprised women of Aga Khani, Dawoodi Bohra and Memon communities. Dietary data was collected through a 108-item food frequency questionnaire and dietary patterns were derived by factor analysis...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Nadeem Ullah Khan, Uzma Rahim Khan, Asher Feroze, Sajjad Ali Khan, Najia Ali, Kiran Ejaz, Afshan Rahim Khan, Shahnila Nooruddin, Jabeen Fayyaz
OBJECTIVE: To determine the trends of acute poisoning in terms of frequency, nature of poisoning agent, clinical presentation and its outcome. METHODS: The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of patients who presented with poisoning between January 1989 and December 2010.The patients were randomly selected , and demographic, chemical information, clinical feature, treatment and outcome were analysed using SPSS 16...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Zafar Ul Islam, Attiya Jawaid Shaikh, Mubassar Fida
OBJECTIVE: To determine and compare the mean dentoalveolar heights (mm) in different vertical and sagittal facial patterns. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Orthodontics Clinic, The Aga Khan University Hospital, Karachi, from September to November 2013. METHODOLOGY: Subjects, aged 15 - 20 years, having fully erupted first permanent molars and central incisors were included in the study from orthodontic records...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Hasanat Sharif, Hamza Zaheer Ansari, Awais Ashfaq, Wasiq Faraz Rawasia, Gulshan Bano, Shiraz Hashmi
OBJECTIVE: To build a clinical predictive model to determine the need for transfusing blood and its products in coronary artery bypass grafting (CABG) procedures in South East Asian population. STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Section of Cardiothoracic Surgery, Aga Khan University Hospital, Karachi, from January 2006 to October 2014. METHODOLOGY: Information on pre-, intra- and postoperative variables were collected for all adult patients who underwent on-pump CABG...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Kulsoom Ghias, Kausar S Khan, Rukhsana Ali, Shireen Azfar, Rashida Ahmed
OBJECTIVE: Aga Khan University, a private medical college, had a vision of producing physicians who are not only scientifically competent, but also socially sensitive, the latter by exposure of medical students to a broad-based curriculum. The objective of this study was to identify the genesis of broad-based education and its integration into the undergraduate medical education program as the Humanities and Social Sciences (HASS) course. METHODS: A qualitative methodology was used for this study...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Tahira Y Malik, Uzma Chishti, Aliya B Aziz, Irfan Sheikh
OBJECTIVE: To compare risk factors and progression free survival of type 1 & 2 endometrial cancers. METHODS: A retrospective analysis of 149 patients with early stage endometrial carcinoma treated between 1997 and 2012 in Aga Khan University Hospital, Karachi was performed. RESULTS: A total of 149 patients were analyzed. Type I tumors accounted for 92% of cases in the study while 8% were type II tumors. The mean age, BMI, parity, co-morbidities (hypertension & Diabetes), family history and history of polycystic disease were comparable in both groups...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Shafia Shakoor, Dhanwanti Dileep, Summera Tirmizi, Sadia Rashid, Yasmin Amin, Shama Munim
OBJECTIVE: To assess the adverse outcome in pregnancies with raised Nuchal translucency measurement. METHODS: This retrospective study was conducted at the Aga Khan University Hospital, Karachi, Pakistan between January 2001 and December 2015. Women attending the Fetal Medicine unit for first trimester screening by Nuchal translucency were included in the study. All pregnancies were followed up till delivery. Those with incomplete information about the delivery were excluded from the analysis...
September 5, 2016: Journal of Maternal-fetal & Neonatal Medicine
Muhammad Ashar Malik, Murad Moosa Khan
BACKGROUND: The economic consequences of mental illnesses are much more than health consequences. In Low and Middle Income Countries (LMIC) the economic impact of mental illnesses is rarely analyzed. This paper attempts to fill the gap in research on economics of mental health in LMIC. We provide economic burden of mental illness in Pakistan that can serve as an argument for reorienting health policy, resource allocation and priority settings. AIM: To estimate economic burden of mental illnesses in Pakistan...
September 2016: Journal of Mental Health Policy and Economics
Humaira Jamshed, Anwar-Ul-Hassan Gilani, Fateh Ali Tipoo Sultan, Faridah Amin, Jamshed Arslan, Sumaira Ghani, Madiha Masroor
OBJECTIVE: Elevated serum uric acid (UA), a biomarker of renal insufficiency, is also an independent prognostic marker for morbidity in coronary artery disease (CAD) and poses serious health risks. This study reports the effect of almond consumption on UA in CAD patients. STUDY DESIGN: A randomized controlled clinical trial was conducted with three groups: no-intervention (NI), Pakistani almonds (PA) or American almonds (AA). Patients were recruited from the Cardiology Clinics, Aga Khan University Hospital...
2016: Nutrition Journal
Ismail Memon, Khalid M Khan, Sammer Siddiqui, Siddiqa Perveen, Muhammad Ishaq
OBJECTIVE: To determine the expression and localisation of the Gβγ-activated adenylyl cyclase (AC) isoforms 2, 4, and 7 and calcineurin-inhibited AC isoform 9 in rat articular chondrocytes. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Jumma Research Laboratory and Histology Laboratory, The Aga Khan University, Karachi, from 2009 to 2011. METHODOLOGY: Fresh slices of articular cartilage were taken from various synovial joints of rats of different age groups...
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Momna Khan, Sana Zahiruddin, Maria Iftikhar
True knot of umbilical cord (TKUC) is a rare abnormality. When it becomes tight, it may lead to the obstruction of the foetal circulation and intrauterine death (IUD). We present two cases of TKUC managed at The Aga Khan University Hospital with two extreme outcomes. A 22 years old primigravida was diagnosed with unexplained intrauterine foetal demise at 28th week gestation. She delivered vaginally after induction and tight TKUC was identified as a cause of IUD. The second patient delivered an alive healthy male baby vaginally who was found to have a lose TKUC...
August 2016: JPMA. the Journal of the Pakistan Medical Association
Erum Khan, Seema Irfan, Binish Arif Sultan, Amna Nasir, Rumina Hasan
OBJECTIVE: To find out frequency of isolation of carbapenem-resistant enterobacteriaceae and the predominantly responsible metallo-beta-lactamasegene in a hospital setting. METHODS: The descriptive, cross-sectional study was conducted from May 2009 to June 2012 at the Aga Khan University Hospital, Karachi, and comprised non-duplicate clinical carbapenem-resistant enterobacteriaceae isolates obtained from different collection units across Pakistan. Kirby-Bauer disk diffusion screening of carbapenem-resistant enterobacteriaceae was confirmed by minimum inhibitory concentration using E-test...
August 2016: JPMA. the Journal of the Pakistan Medical Association
Akbar J Zubairi, Santosh Kumar, Yasir Mohib, Rizwan H Rashid, Shahryar Noordin
OBJECTIVES: To identify incidence and utility of histopathology in wrist ganglions.  METHODS: A retrospective study of 112  patients operated for wrist swellings between January 2009 and March 2014 at Aga Khan University Hospital, Karachi, Pakistan, was conducted. Medical records were reviewed for demographics, history, location and associated symptoms, provisional diagnosis and operative details. Histopathology reports were reviewed to confirm the final diagnosis...
August 2016: Saudi Medical Journal
Kauser Jabeen, Pushpa Bhawan Mal, Erum Khan, Saeeda Chandio, Susanne Jacobsson, Magnus Unemo
BACKGROUND: Globally, increasing antimicrobial resistance (AMR) in Neisseria gonorrhoea has led to decreased treatment options for gonorrhoea. Continuous monitoring of resistance is crucial to determine evolving resistance trends in Neisseria gonorrhoea and to suggest treatment recommendations. Quality assured gonococcal AMR data from Pakistan are mainly lacking. This study was performed to determine prevalence and trends of gonococcal AMR and molecular epidemiology of local strains during 2012-2014 in Karachi, Pakistan...
2016: BMC Infectious Diseases
Nighat Haider, Abdul Sattar Shaikh, Rehana Wazir, Mehnaz Atiq
BACKGROUND: Myocarditis is an inflammatory disorder of myocardium associated with high mortality and morbidity. It is often difficult to diagnose because it can either be asymptomatic or mimic other illnesses. This study is conducted to evaluate clinicodemographic features and outcome of acute myocarditis in children admitted at a tertiary care hospital. METHODS: Medical records of all children aged 1month to 16years who were admitted between 2005 and 2013 at Aga Khan University Hospital, Karachi and discharged with a diagnosis of myocarditis were reviewed retrospectively...
October 15, 2016: International Journal of Cardiology
Rehana Rehman, Kulsoom Ghias, Syeda Sadia Fatima, Mehwish Hussain, Faiza Alam
OBJECTIVE: To assess educational environment in Aga Khan University Medical College (AKUMC) by Dundee Ready Educational Environmental Measure (DREEM) scale. METHODS: A cross-sectional survey of students at the AKUMC with simple random sampling was carried out from June 2014 till March 2015. Responses in five subscales were used to calculate DREEM scores. RESULTS: The average DREEM score was 125.77±16.8 with a reliability of 91.3%. With regards to subscales, on the 12-item students' perceptions of learning (PoL) subscale, the maximum score was 48; 11 items of students' perceptions of teachers (PoT) had a maximum score of 44; students' academic self-perceptions (ASP) identified by 8 items showed maximum score of 32; students' perceptions of atmosphere (PoA) with 12 items obtained maximum score 48 and students' social self-perceptions (SSP) subscale of 7 items had a maximum score of 28...
May 2016: Pakistan Journal of Medical Sciences Quarterly
Saroona Haroon, Muhammad Usman Tariq, Aisha Memon, Saira Fatima, Sheema Habibul Hasan
OBJECTIVES: To present the clinicopathological experience of Olfactory Neuroblastoma (ONB) with emphasis on histopathological and immunohistochemical features. METHODS: A descriptive cross-sectional study was done on 36 cases of ONB, selected by non-probability purposive sampling. Theses cases of ONB were retrieved and reviewed from surgical pathology database of Aga Khan University Hospital reported between January 1993 and March 2015. RESULTS: Tumor size and age of presentation was wide in range without any distinct bimodal distribution...
May 2016: Pakistan Journal of Medical Sciences Quarterly
Jamal Kabeer Khan, Syed Shahabuddin, Sheema Khan, Gulshan Bano, Shiraz Hashmi, Shahid A Sami
BACKGROUND: Outcomes following Coronary artery bypass grafting (GABG) vary between genders, with females having a higher postoperative mortality than males. Most of the studies are on Caucasian or mixed population and it is postulated that Asian population and in particular women have higher morbidity and mortality. In this study we have compared outcomes of elective CABG in men and women of South Asian origin in terms of morbidity and mortality. METHODS: From January 2006 to December 2012, 1970 patients underwent isolated elective CABG at the Aga Khan University Hospital, Pakistan were selected...
August 2016: Annals of Medicine and Surgery
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