Kousuke Yamauchi, Takahiro Yoshihara, Sayaka Suzuki, Hideto Sugawara, Shinya Maehara, Masahiro Sato, Ryuichi Nishida, Tsutomu Azuma, Junji Yamamoto, Kiyokazu Nakajima
Various types of hemostatic agents are used to manage bleeding in surgery. Many such agents are animal products, which carry the risk of secondary infection. The aim of this study is to develop a novel hemostatic agent from a non-animal source that quickly stops bleeding, is easy to use, and has no risk of infection. In this study, we synthesized calcium ion-crosslinked sodium alginate (Alg-Na/Ca) by partial substitution of Ca ions for Na ions in sodium alginate. We prepared 12 kinds of Alg-Na/Ca powders with different Ca mass ratios, molecular weights, M/G ratios and particle size distributions and measured their swelling ratio and the burst pressure generated...
March 21, 2024: International Journal of Biological Macromolecules