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International ketogenic diet study group

Francesco Brigo, Stanley C Igwe, Nicola Luigi Bragazzi
BACKGROUND: This is an updated version of the original Cochrane review published in 2015, Issue 10.Severe myoclonic epilepsy in infants (SMEI), also known as Dravet syndrome, is a rare, refractory form of epilepsy, for which stiripentol (STP) has been recently licensed as add-on therapy. OBJECTIVES: To evaluate the efficacy and tolerability of STP and other antiepileptic drug treatments (including ketogenic diet) for patients with SMEI. SEARCH METHODS: For the latest update we searched the Cochrane Epilepsy Group Specialized Register (20 December 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online (CRSO, 20 December 2016), MEDLINE (Ovid, 1946 to 20 December 2016) and ClinicalTrials...
May 18, 2017: Cochrane Database of Systematic Reviews
Kirsty Martin, Cerian F Jackson, Robert G Levy, Paul N Cooper
BACKGROUND: The ketogenic diet (KD), being high in fat and low in carbohydrates, has been suggested to reduce seizure frequency. It is currently used mainly for children who continue to have seizures despite treatment with antiepileptic drugs. Recently, there has been interest in less restrictive KDs including the modified Atkins diet (MAD) and the use of these diets has extended into adult practice. OBJECTIVES: To review the evidence for efficacy and tolerability from randomised controlled trials regarding the effects of KD and similar diets...
February 9, 2016: Cochrane Database of Systematic Reviews
Joanna Chwiej, Agnieszka Skoczen, Krzysztof Janeczko, Justyna Kutorasinska, Katarzyna Matusiak, Henryk Figiel, Paul Dumas, Christophe Sandt, Zuzanna Setkowicz
In this study, ketogenic diet-induced biochemical changes occurring in normal and epileptic hippocampal formations were compared. Four groups of rats were analyzed, namely seizure experiencing animals and normal rats previously fed with ketogenic (KSE and K groups respectively) or standard laboratory diet (NSE and N groups respectively). Synchrotron radiation based Fourier-transform infrared microspectroscopy was used for the analysis of distributions of the main organic components (proteins, lipids, compounds containing phosphate group(s)) and their structural modifications as well as anomalies in creatine accumulation with micrometer spatial resolution...
April 7, 2015: Analyst
Shigeru Nakamura, Ryuji Hisamura, Sachiko Shimoda, Izumi Shibuya, Kazuo Tsubota
BACKGROUND: Fasting is a rigorous type of dietary restriction that is associate with a number of health benefits. During fasting, ketone bodies significantly increase in blood and become major body fuels, thereby sparing glucose. In the present study, we investigated effects of fasting on hypersensitivity. In addition, we also investigated the possible role of D-beta-hydroxybutyrate provoked by fasting in the attenuation of immediate hypersensitivity by fasting. METHODS: Effects of fasting on systemic anaphylaxis were examined using rat model of toluene 2, 4-diisocyanate induced nasal allergy...
2014: Nutrition & Metabolism
Francesco Brigo, Monica Storti
BACKGROUND: Severe myoclonic epilepsy in infants (SMEI), also known as Dravet syndrome, is a rare, refractory form of epilepsy, for whose treatment stiripentol (STP) has been recently licensed for add-on use. OBJECTIVES: To evaluate the efficacy and tolerability of STP and other antiepileptic drug treatments (including ketogenic diet) as therapy for patients with SMEI. SEARCH METHODS: We searched the Cochrane Epilepsy Group Specialised Register (15 May 2013), the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 4 of 12, The Cochrane Library, April 2013), MEDLINE (1946 to May 2013) and SCOPUS (1823 to May 2013)...
2013: Cochrane Database of Systematic Reviews
Eric H Kossoff, Adam L Hartman
PURPOSE OF REVIEW: Despite myriad anticonvulsants available and in various stages of development, there are thousands of children and adults with epilepsy worldwide still refractory to treatment and not candidates for epilepsy surgery. Many of these patients will now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride diet, modified Atkins diet, and low glycemic index treatment. RECENT FINDINGS: In the past several years, neurologists are finding new indications to use these dietary treatments, perhaps even as first-line therapy, including infantile spasms, myoclonic-astatic epilepsy (Doose syndrome), Dravet syndrome, and status epilepticus (including FIRES syndrome)...
April 2012: Current Opinion in Neurology
Pierangelo Veggiotti, Alberto Burlina, Giangennaro Coppola, Raffaella Cusmai, Valentina De Giorgis, Renzo Guerrini, Anna Tagliabue, Bernardo Dalla Bernardina
Ketogenic diet is a nonpharmacologic treatment for childhood epilepsy not amenable to drugs. At the present time, two works based on national research, one in Germany and one in the United States provide international guidelines to ensure a correct management of the ketogenic diet. Our Italian collaborative study group was set up in order to formulate a consensus statement regarding the clinical management of the ketogenic diet, patient selection, pre-ketogenic diet, counseling, setting and enforcement of dietary induction of ketosis, follow-up management, and eventual discontinuation of the diet...
April 2011: Epilepsia
Eric H Kossoff, Beth A Zupec-Kania, Per E Amark, Karen R Ballaban-Gil, A G Christina Bergqvist, Robyn Blackford, Jeffrey R Buchhalter, Roberto H Caraballo, J Helen Cross, Maria G Dahlin, Elizabeth J Donner, Joerg Klepper, Rana S Jehle, Heung Dong Kim, Y M Christiana Liu, Judy Nation, Douglas R Nordli, Heidi H Pfeifer, Jong M Rho, Carl E Stafstrom, Elizabeth A Thiele, Zahava Turner, Elaine C Wirrell, James W Wheless, Pierangelo Veggiotti, Eileen P G Vining
The ketogenic diet (KD) is an established, effective nonpharmacologic treatment for intractable childhood epilepsy. The KD is provided differently throughout the world, with occasionally significant variations in its administration. There exists a need for more standardized protocols and management recommendations for clinical and research use. In December 2006, The Charlie Foundation commissioned a panel comprised of 26 pediatric epileptologists and dietitians from nine countries with particular expertise using the KD...
February 2009: Epilepsia
Arne Astrup, Thomas Meinert Larsen, Angela Harper
CONTEXT: The Atkins diet books have sold more than 45 million copies over 40 years, and in the obesity epidemic this diet and accompanying Atkins food products are popular. The diet claims to be effective at producing weight loss despite ad-libitum consumption of fatty meat, butter, and other high-fat dairy products, restricting only the intake of carbohydrates to under 30 g a day. Low-carbohydrate diets have been regarded as fad diets, but recent research questions this view. STARTING POINT: A systematic review of low-carbohydrate diets found that the weight loss achieved is associated with the duration of the diet and restriction of energy intake, but not with restriction of carbohydrates...
September 4, 2004: Lancet
V G RĂ­os
INTRODUCTION: It was originally claimed that the ketogenic diet (KC) caused no major adverse effects. Few studies have been done to analyze the side effects and complications of the KC. OBJECTIVES: To analyze the side effects and complications seen in a group of patients on KC compared with those described in the international literature. PATIENTS AND METHODS: We made a prospective evaluation of 22 patients aged between one and nineteen years, over an average period of 25 months...
November 16, 2001: Revista de Neurologia
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