keyword
https://read.qxmd.com/read/37977712/classic-ketogenic-diet-versus-further-antiseizure-medicine-in-infants-with-drug-resistant-epilepsy-kiwe-a-uk-multicentre-open-label-randomised-clinical-trial
#21
RANDOMIZED CONTROLLED TRIAL
Natasha E Schoeler, Louise Marston, Laura Lyons, Sally Halsall, Ruchika Jain, Siobhan Titre-Johnson, Maryam Balogun, Simon J R Heales, Simon Eaton, Michael Orford, Elizabeth Neal, Colin Reilly, Christin Eltze, Elma Stephen, Andrew A Mallick, Finbar O'Callaghan, Shakti Agrawal, Alasdair Parker, Martin Kirkpatrick, Andreas Brunklaus, Ailsa McLellan, Helen McCullagh, Rajib Samanta, Rachel Kneen, Hui Jeen Tan, Anita Devlin, Manish Prasad, Rohini Rattihalli, Helen Basu, Archana Desurkar, Ruth Williams, Penny Fallon, Irwin Nazareth, Nick Freemantle, J Helen Cross
BACKGROUND: Many infancy-onset epilepsies have poor prognosis for seizure control and neurodevelopmental outcome. Ketogenic diets can improve seizures in children older than 2 years and adults who are unresponsive to antiseizure medicines. We aimed to establish the efficacy of a classic ketogenic diet at reducing seizure frequency compared with further antiseizure medicine in infants with drug-resistant epilepsy. METHODS: In this phase 4, open-label, multicentre, randomised clinical trial, infants aged 1-24 months with drug-resistant epilepsy (defined as four or more seizures per week and two or more previous antiseizure medications) were recruited from 19 hospitals in the UK...
December 2023: Lancet Neurology
https://read.qxmd.com/read/37961656/ketogenic-diet-improves-motor-function-and-motor-unit-connectivity-in-aged-c57bl-6-mice
#22
Carlos J Padilla, Hallie Harris, Jeff S Volek, Brian C Clark, W David Arnold
UNLABELLED: Objective Pathological, age-related loss of muscle function, commonly referred to as sarcopenia, contributes to loss of mobility, impaired independence, as well as increased risk of adverse health events. Sarcopenia has been attributed to changes in both neural and muscular integrity during aging. Current treatment options are primarily limited to exercise and dietary protein fortification, but the therapeutic impact of these approaches are often inadequate. Prior work has suggested that a ketogenic diet (KD) might improve healthspan and lifespan in aging mice...
October 27, 2023: Research Square
https://read.qxmd.com/read/37950240/opposite-effects-of-low-carbohydrate-high-fat-diet-on-metabolism-in-humans-and-mice
#23
JOURNAL ARTICLE
Lingli Cai, Xinyi Xia, Yunjie Gu, Lili Hu, Cheng Li, Xiaojing Ma, Jun Yin
BACKGROUND: Low-carbohydrate diet (LCD) is effective for weight loss and glycaemic control in humans. Here, the study aimed to explore the effects of LCD/high-fat diet (HFD) in both humans and mice. METHODS: Twenty-two overweight or obese participants received LCD for 3 weeks. Based on carbohydrate intake > 10% or ≤ 10% of calories, the participants were divided into moderate LCD (MLCD) and very LCD (VLCD) groups. The participants completed a 10-question food preference survey...
November 10, 2023: Lipids in Health and Disease
https://read.qxmd.com/read/37904380/effects-of-a-two-meals-a-day-ketogenic-diet-on-newly-diagnosed-obese-patients-with-type-2-diabetes-mellitus-a-retrospective-observational-study
#24
JOURNAL ARTICLE
Sumei Li, Shouping Yuan, Guoxin Lin, Jintian Zhang
To investigate the effects of a two-meals-a-day energy-restricted ketogenic diet (KD) on newly diagnosed obese patients with type 2 diabetes mellitus. In total, 60 obese patients with newly diagnosed type 2 diabetes mellitus were divided into 2 groups: 1 group followed a 2-meals-a-day KD and the other group followed a conventional diabetic diet. Changes in weight, blood glucose, blood lipids, insulin resistance, and uric acid levels were observed before and after 2 months of adhering to the respective diets under energy restriction...
October 27, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37892542/effects-of-an-eight-week-very-low-calorie-ketogenic-diet-vlckd-on-white-blood-cell-and-platelet-counts-in-relation-to-metabolic-dysfunction-associated-steatotic-liver-disease-masld-in-subjects-with-overweight-and-obesity
#25
JOURNAL ARTICLE
Sara De Nucci, Caterina Bonfiglio, Rosanna Donvito, Martina Di Chito, Nicole Cerabino, Roberta Rinaldi, Annamaria Sila, Endrit Shahini, Vito Giannuzzi, Pasqua Letizia Pesole, Sergio Coletta, Elsa Lanzilotta, Giuseppina Piazzolla, Raffaele Cozzolongo, Gianluigi Giannelli, Giovanni De Pergola
Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are frequently associated conditions characterized by low-grade inflammation. Very low-calorie ketogenic diet (VLCKD) strategies are commonly used to simultaneously obtain weight loss and an improvement of liver steatosis. We evaluated the efficacy of 8 weeks' VLCKD in decreasing the white blood cell (WBC) and platelet (PLT) counts, as well as liver steatosis and fibrosis, diagnosed using transient elastography (FibroScan). Metabolic and anthropometric parameters commonly associated with MASLD were also evaluated...
October 21, 2023: Nutrients
https://read.qxmd.com/read/37892502/ketogenic-diet-exacerbates-l-arginine-induced-acute-pancreatitis-and-reveals-the-therapeutic-potential-of-butyrate
#26
JOURNAL ARTICLE
He Xia, Jing Guo, Jian Shen, Shiman Jiang, Shengyi Han, Lanjuan Li
The ketogenic diet (KD) has emerged as a popular weight-loss regimen in recent years. However, it has been confirmed to elicit a mild inflammatory response in the intestinal epithelium and exacerbate various digestive disorders. The severity of acute pancreatitis (AP) is closely associated with the permeability of the intestinal epithelium and gut microbiota, yet the impact of KD on acute pancreatitis remains unclear. In this study, we induced acute pancreatitis using L-arginine in mice fed with KD. The consumption of KD resulted in an elevation of lipopolysaccharide-binding protein (LBP), accompanied by upregulated cytokines (IL-1a, IL-5, IL-12, MIP-1a, and Rantes) and dysfunction of the intestinal barrier both in control and AP groups...
October 18, 2023: Nutrients
https://read.qxmd.com/read/37870676/a-ketogenic-diet-may-improve-cognitive-function-in-rats-with-temporal-lobe-epilepsy-by-regulating-endoplasmic-reticulum-stress-and-synaptic-plasticity
#27
JOURNAL ARTICLE
Qi Qiao, Shuang Tian, Yuan Zhang, Liqin Che, Qing Li, Zhenzhen Qu, Weiping Wang
A ketogenic diet (KD) is often used in the treatment of refractory epilepsy. Many studies have found that it also has a positive impact on cognitive comorbidities, but the specific mechanism remains unclear. In many disease models, endoplasmic reticulum stress (ERS) and synaptic plasticity is considered a new therapeutic target for improving cognitive impairment, and it has become a research focus in recent years. Recently, studies have found that a KD has a certain regulatory effect on both ERS and synaptic plasticity, but this result has not been confirmed in epilepsy...
October 23, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37861951/how-food-choices-impact-on-male-fertility
#28
REVIEW
Giulia Pecora, Francesca Sciarra, Elena Gangitano, Mary Anna Venneri
PURPOSE OF REVIEW: Increasing evidence on the significance of nutrition in reproduction is emerging from both animal and human studies, suggesting an association between nutrition and male fertility. Here, we have highlighted the impact of the various food groups on reproductive hormones and on spermatogenesis, and the effects of classical and latest dietary patterns such as Mediterranean diet, Western diet, intermittent fasting, ketogenic diet, and vegan/vegetarian diet on male fertility...
December 2023: Current Nutrition Reports
https://read.qxmd.com/read/37832180/role-of-insulin-resistance-and-leptin-in-the-effect-of-intermittent-feeding-with-a-high-protein-ketogenic-diet-on-body-composition-in-rats
#29
JOURNAL ARTICLE
Gul Eyikudamaci, Hasan Ege, Nihal Ensen, Nermin Yelmen
OBJECTIVES: The prevalence of obesity and overweight in children has been increasing rapidly worldwide and threatens society with various chronic diseases that these children are born with. High-protein ketogenic diets and intermittent nutrition are thought to be protective against obesity and metabolic syndrome MetS. However, the exact effects and results, insulin resistance, and the role of leptin in the functioning mechanism of these diets have not been fully elucidated. The aim of this study was to investigate the roles of insulin resistance and leptin hormone on the effects of body composition with a high-protein ketogenic diet and intermittent nutrition combination...
January 2024: Nutrition
https://read.qxmd.com/read/37818128/hepatic-safety-profile-of-pancreatic-cancer%C3%A2-bearing-mice-fed-a-ketogenic-diet-in-combination-with-gemcitabine
#30
JOURNAL ARTICLE
Natalia E Cortez, Cecilia Rodriguez Lanzi, Payam Vahmani, Karen Matsukuma, Gerardo G Mackenzie
Ketogenic diets (KDs) are actively being evaluated for their potential anticancer effects. Although KDs are generally considered safe, their safety profile when combined with chemotherapy remains unknown. It is known that a KD enhances the anticancer effect of gemcitabine (2',2'-difluoro-2'-deoxycytidine) in LSL-Kras LSL-G12D/+ Trp53 R172H/+ Pdx-1 -Cre (KPC) tumor-bearing mice. In the present study, whether a KD in combination with gemcitabine affected the liver safety profile in KPC mice was evaluated. For this purpose, male and female pancreatic tumor-bearing KPC mice were allocated to a control diet (CD; % kcal: 20% fat, 65% carbohydrate, 15% protein) + gemcitabine [control plus gemcitabine group (CG)] or a KD (% kcal: 84% fat, 15% protein, 1% carbohydrate) + gemcitabine [ketogenic plus gemcitabine group (KG)] for two months...
November 2023: Oncology Letters
https://read.qxmd.com/read/37810917/effect-of-the-mediterranean-diet-supplemented-with-nicotinamide-riboside-and-pterostilbene-and-or-coconut-oil-on-anthropometric-variables-in-amyotrophic-lateral-sclerosis-a-pilot-study
#31
JOURNAL ARTICLE
Sandra Carrera-Juliá, José M Estrela, Mario Zacarés, Mari Ángeles Navarro, María Jesús Vega-Bello, José Enrique de la Rubia Ortí, Mari Luz Moreno, Eraci Drehmer
Amyotrophic Lateral Sclerosis (ALS) is a chronic and progressive neurodegenerative disease that causes the death of motor neurons and alters patients' body composition. Supplementation with the antioxidants nicotinamide riboside (NR) and pterostilbene (PTER) can combat associated oxidative stress. Additionally, coconut oil is an alternative energy substrate that can address mitochondrial dysfunction. The aim of the present study is to assess the impact of a Mediterranean Diet supplemented with NR and PTER and/or with coconut oil on the anthropometric variables of patients with ALS...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37810861/antioxidant-and-antilipidemic-action-of-ketogenic-diet-and-tomato-powder-mix-in-high-sugar-and-fat-fed-harwich-fruit-flies
#32
JOURNAL ARTICLE
Omowumi T Kayode, Olatayo A Afolabi, Gabriel O Ajayi
Numerous studies have demonstrated the role of oxidative stress in metabolic disorders which presents as a major global problem. The antioxidant properties of the tomato fruit and the ketogenic diet has likewise been established by different authors. This study uses a fruit fly model to examine the synergistic effect of a ketogenic diet and tomato powder mix on biochemical alterations induced by the High-Fat Diet (HFD) and the High-Sugar Diet (HSD). Six groups of male fruit flies consisting of fifty flies per vial were administered Normal Diet (ND), High-Fat Diet (HFD), High Sugar Diet (HSD), Ketogenic Diet (KD), Tomato Powder-mix (TP), and HSD + HFD, for ten days...
October 2023: Heliyon
https://read.qxmd.com/read/37794395/very-low-calorie-ketogenic-diet-vs-hypocaloric-balanced-diet-in-the-prevention-of-high-frequency-episodic-migraine-the-emiketo-randomized-controlled-trial
#33
RANDOMIZED CONTROLLED TRIAL
Massimiliano Caprio, Eleonora Moriconi, Elisabetta Camajani, Alessandra Feraco, Vincenzo Marzolla, Laura Vitiello, Stefania Proietti, Andrea Armani, Stefania Gorini, Caterina Mammi, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Carlo Tomino, Piero Barbanti
BACKGROUND: Migraine is the second world's cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one of the most promising approaches. METHODS: This a prospective, single center, randomized, controlled study aimed at evaluating the efficacy of a very low-calorie ketogenic diet (VLCKD) compared to a hypocaloric balanced diet (HBD) in migraine prophylaxis in patients affected by high-frequency episodic migraine (HFEM) with a Body Mass Index (BMI) > 27 kg/m2 ...
October 4, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37759424/use-of-ketogenic-dietary-therapy-for-drug-resistant-epilepsy-in-early-infancy
#34
JOURNAL ARTICLE
Marisa Armeno, Silvana Calligaris, Daniela Gagiulo, Araceli Cresta, Maria Magdalena Vaccarezza, Cecilia Griselda Diez, Maria Julia Alberti, Rocio Viollaz, Francisco Vilavedra, Roberto H Caraballo
OBJECTIVE: There is growing evidence that ketogenic dietary therapy (KDT) can be safely and efficiently used in young children, but little evidence exists on its use in newborns. Developmental and epileptic encephalopathies starting in the neonatal period or early infancy usually present a poor prognosis. The aim of this study was to evaluate effectiveness, safety, and survival of infants younger than 3 months of age with drug-resistant epilepsy in whom KDT was used. METHODS: A retrospective study was conducted to evaluate neonates and infants younger than 3 months who started KDT for drug-resistant developmental and epileptic encephalopathies at three referral centers...
September 27, 2023: Epilepsia Open
https://read.qxmd.com/read/37746660/transcriptomic-and-metabolomic-insights-into-the-roles-of-exogenous-%C3%AE-hydroxybutyrate-acid-for-the-development-of-rumen-epithelium-in-young-goats
#35
JOURNAL ARTICLE
Yimin Zhuang, Jianmin Chai, Mahmoud M Abdelsattar, Yuze Fu, Naifeng Zhang
Beta-hydroxybutyric acid (BHBA), as one of the main metabolic ketones in the rumen epithelium, plays critical roles in cellular growth and metabolism. The ketogenic capacity is associated with the maturation of rumen in young ruminants, and the exogenous BHBA in diet may promote the rumen development. However, the effects of exogenous BHBA on rumen remain unknown. This is the first study to investigate the mechanisms of BHBA on gene expression and metabolism of rumen epithelium using young goats as a model through multi-omics techniques...
December 2023: Animal Nutrition
https://read.qxmd.com/read/37712283/-a-transcriptomic-study-of-osteoporosis-induced-by-ketogenic-diet-in-mice
#36
JOURNAL ARTICLE
X Wu, Y Fan, Y Ye, P Li, Q Zhu, Z Chen, B Li, W Wang, L Zheng
OBJECTIVE: To investigate the molecular mechanism of osteoporosis caused by ketogenic diet (KD) using transcriptomic analysis. METHODS: Sixteen 8-week-old female C57BL/6J mice were divided into KD group and sham group for feeding with KD and normal diet for 3 months, respectively. Body weight, blood glucose and blood ketone levels of the mice were measured every two weeks. Microstructure of the cancellous bone in the distal femur was observed with Micro-CT. Total RNA was extracted from bone marrow cells for transcriptomic analysis and bioinformatics analysis...
August 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/37685147/validation-of-an-italian-questionnaire-of-adherence-to-the-ketogenic-dietary-therapies-iketocheck
#37
JOURNAL ARTICLE
Lenycia de Cassya Lopes Neri, Monica Guglielmetti, Valentina De Giorgis, Ludovica Pasca, Martina Paola Zanaboni, Claudia Trentani, Elena Ballante, Serena Grumi, Cinzia Ferraris, Anna Tagliabue, On Behalf Of The KDTs Delphi Validation Study Group
Ketogenic dietary therapies (KDTs) are an effective and safe non-pharmacological treatment for drug-resistant epilepsy, but adherence can be challenging for both patients and caregivers. In Europe, there are no adequate tools to measure it other than monitoring ketosis. This study aimed to adapt and validate the Brazilian adherence questionnaire, Keto-check, into the Italian version: iKetoCheck. Using the Delphi technique, 12 judges validated the contents through agreement rates and the Content Validity Index (CVI)...
August 26, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/37679873/ketogenic-diets-in-children-with-intractable-epilepsy-and-its-effects-on-gastrointestinal-function-gut-microbiome-inflammation-and-quality-of-life
#38
JOURNAL ARTICLE
Jessica Menzies, Alamelu Sundararaj, Michael Cardamone, Alexandra McHarg, Steven Leach, Usha Krishnan
OBJECTIVES: The ketogenic diet (KD) is a treatment for children with intractable epilepsy (IE), can cause gastrointestinal symptoms, and have an adverse effect on growth, nutrition and quality of life (QOL). This study investigated the extent of these side effects by comparing children with IE on KDs to their counterparts on normal diets. METHODS: Patients with IE were categorized into patients with KD or control groups. Gastrointestinal side effects and QOL were assessed using the PedsQL Gastrointestinal Symptoms Module...
November 1, 2023: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/37674514/timing-of-therapeutic-interventions-against-infection-triggered-encephalopathy-syndrome-a-scoping-review-of-the-pediatric-literature
#39
REVIEW
Hiroaki Nagase, Hiroshi Yamaguchi, Shoichi Tokumoto, Yusuke Ishida, Kazumi Tomioka, Masahiro Nishiyama, Kandai Nozu, Azusa Maruyama
Our goal was to conduct a scoping review of the literature on the treatment of infection-triggered encephalopathy syndrome/acute encephalopathy in children, focusing on treatment targets and treatment initiation timing. We performed literature searches using PubMed for articles reporting treatments of infection-triggered encephalopathy syndrome/acute encephalopathy. We included articles describing specific treatments for acute encephalopathy with control groups. For the purpose of searching new therapies only experimentally tried in the case series, we also included case series studies without control groups in this review, if the studies contained at least two cases with clear treatment goals...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37630844/modified-mediterranean-ketogenic-diet-and-carboxytherapy-as-personalized-therapeutic-strategies-in-lipedema-a-pilot-study
#40
JOURNAL ARTICLE
Laura Di Renzo, Paola Gualtieri, Samanta Zomparelli, Gemma Lou De Santis, Silvia Seraceno, Claudia Zuena, Giulia Frank, Rossella Cianci, Domenico Centofanti, Antonino De Lorenzo
In recent years, the use of the ketogenic diet as a proper nutritional treatment for lipedema has been hypothesized in the literature. This is the first clinical study evaluating the ketogenic diet and carboxytherapy in lipedema patients. In the present study, it was decided to use a modified Mediterranean ketogenic diet (MMKD) in combination with carboxytherapy. Since lipedema is characterized by microangiopathy, local hypoxia, and increased subcutaneous adipose tissue (SAT) deposition, carboxytherapy could improve painful symptoms and skin tone...
August 20, 2023: Nutrients
keyword
keyword
59643
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.