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https://www.readbyqxmd.com/read/29793192/how-did-older-adults-respond-to-challenges-after-an-earthquake-results-from-a-qualitative-study-in-iran
#1
Shokoufeh Ahmadi, Hamidreza Khankeh, Robab Sahaf, Asghar Dalvandi, Seyed Ali Hosseini, Fardin Alipour
OBJECTIVES: In many areas, natural disasters are a major challenge for life and property of people. Earthquake is one of the most devastating natural disasters. This study aimed to explore how older adults responded to challenges after the earthquake in Iran. METHODS: This study was based on qualitative analysis. Data were collected through in-depth and semi-structured interviews. 29 participants including 18 older adult survivors of the earthquake-stricken areas, four lay caregivers, and three health professionals in disasters, one social worker, two relief worker and one disaster psychologist were interviewed...
May 17, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29793171/compositional-engineering-of-acceptors-for-highly-efficient-bulk-heterojunction-hybrid-organic-solar-cells
#2
S Amber Yousaf, M Ikram, S Ali
The wet chemical synthesis of chromium oxide (Cr2 O3 ) nanoparticles (NPs) and its application in active layer of inverted bulk heterojunction organic solar cells is documented in this research. Chromium oxide NPs of 10-30 nm size range having a band gap of 2.9 eV were successfully synthesized. These NPs were used in inverted organic solar cells in amalgamation with P3HT:PCBM and PTB7:PCBM polymers. The fabricated hybrid devices improves PCE significantly for P3HT:PCBM and PTB7:PCBM systems. The photophysical energy levels, optoelectrical properties and microscopic images have been systematically studied for the fabricated devices...
May 21, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793142/synthesis-of-aryl-pyrazole-via-suzuki-coupling-reaction-in-vitro-mushroom-tyrosinase-enzyme-inhibition-assay-and-in-silico-comparative-molecular-docking-analysis-with-kojic-acid
#3
Pervaiz Ali Channar, Aamer Saeed, Fayaz Ali Larik, Bakhtawar Batool, Saima Kalsoom, M M Hasan, Mauricio F Erben, Hesham R El-Seedi, Musrat Ali, Zaman Ashraf
Aryl pyrazoles are well recognized class of heterocyclic compounds found in several commercially available drugs. Owing to their significance in medicinal chemistry, in this current account we have synthesized a series of suitably substituted aryl pyrazole by employing Suzuki cross-coupling reaction. All compounds were evaluated for inhibition of mushroom tyrosinase enzyme both in vitro and in silico. Compound 3f (IC50  = 1.568 ± 0.01 µM) showed relatively better potential compared to reference kojic acid (IC50  = 16...
April 30, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29793133/an-ultrasensitive-and-selective-electrochemical-aptasensor-based-on-rgo-mwcnts-chitosan-carbon-quantum-dot-for-the-detection-of-lysozyme
#4
Behzad Rezaei, Hamid Reza Jamei, Ali Asghar Ensafi
An aptamer-based method is described for the electrochemical determination of lysozyme. A glassy carbon electrode was modified with a nanocomposite composed of reduced graphene oxide (rGO), multi-walled carbon nanotubes (MWCNTs), chitosan (CS), and a synthesized carbon quantum dot (CQD) from CS. The composition of the nanocomposite (rGO-MWCNT/CS/CQD) warrants a high surface-to-volume ratio, high conductivity, high stability, and great electrocatalytic activity. This nanocomposite provides a suitable site for better immobilization of aptamers due to the existence of many amino and carboxyl functional groups, and remaining oxygen-related defects properties in rGO...
May 9, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29793085/socio-demographic-factors-associated-with-choosing-violent-methods-of-suicide-2011-2016-ilam-province
#5
Yousef Veisani, Fathola Mohamadian, Ali Delpisheh, Salman Khazaei
BACKGROUND: In new strategies towards of suicide prevention the best approach currently is based on specific method had specific risk factors. Therefore in this study we aimed to find out the association between socio-demographic factors and methods in completed suicide, 2011-2016, Ilam province. METHODS: A cross-sectional study, 2011-2016, was conducted. A total of 540 completed suicides were recruited to the study. Data were collected by systematic registration suicide data (SRSD) and Legal Medicine Organization (LMO)...
May 21, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29793051/promising-antileishmanial-activity-of-novel-imidazole-antifungal-drug-luliconazole-against-leishmania-major-in-vitro-and-in-silico-studies
#6
Azar Shokri, Mahdi Abastabar, Masoud Keighobadi, Saeed Emami, Mahdi Fakhar, Saeed Hosseini Teshnizi, Koichi Makimura, Ali Rezaei-Matehkolaei, Hassan Mirzaei
OBJECTIVES: Pentavalent antimonials have been used for the treatment of leishmaniasis for more than 70 years; however their toxicity limits their benefits. Unfortunately, the efficacy of the first line drugs has been decreased and resistance seems to be noticeable. Luliconazole is a new azole with unique effects on fungi which has not been tested on Leishmania parasites yet. METHODS: In the present study, we evaluated cytotoxicity and anti-leishmanial activities of Luliconazole on promastigotes and intracellular amastigotes of Leishmania major (L...
May 21, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29792959/fabrication-and-cytotoxicity-assessment-of-cellulose-nanofibrils-using-bassia-eriophora-biomass
#7
Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Ali A Alshatwi
Cellulose nanofibrils (CNs) are eco-friendly, biodegradable, biocompatible, renewable, cost-effective, and possess excellent mechanical properties. We fabricated CNs from Bassia eriophora biomass, and the structure and morphology were investigated by transmission electron microscopy that revealed 2-6 μm long fibrillated structures with diameters of 15-40 nm. CNs biocompatibility was assessed using in vitro based assays, including cell viability assay, AO/EB staining, Hoechst staining, JC-1 staining, and gene expression analysis...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792538/single-nucleotide-polymorphisms-in-il23r-il12rb2-rs1495965-are-highly-prevalent-in-patients-with-behcet-s-uveitis-and-vary-between-populations
#8
Michal Kramer, Murat Hasanreisoglu, Shirel Weiss, Deniz Kumova, Michal Schaap-Fogler, Sezen Guntekin-Ergun, Sengul Ozdek, Gokhan Gurelik, Mehmet Ali Ergün, Nitza Goldenberg-Cohen, Yoram Cohen
PURPOSE: To test the frequency of single-nucleotide polymorphisms in the IL-10, IL23R-IL12RB2 genes in patients with Behcet's uveitis. METHODS: Blood samples were collected from 89 Israeli and Turkish patients, and from healthy control subjects of different origins. Genomic DNA was extracted from peripheral blood leukocytes and genotyped. RESULTS: The risk allele, A, in rs1800871, of IL-10 gene was highly prevalent in Behcet's uveitis and healthy control samples alike; highest among the Turkish groups...
May 24, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29792536/outcomes-in-paediatric-external-dacryocystorhinostomy-a-single-centre-experience
#9
Tarjani Vivek Dave, Edak Ezeanosike, Milind N Naik, Mohammad Javed Ali
PURPOSE: To report the outcomes of external dacryocystorhinostomy (Ext DCR) in paediatric patients. METHODS: A single-centre, retrospective, interventional, non-comparative case series was performed on all paediatric patients who underwent Ext DCR between July 2010 and July 2014. Surgery was performed as per standard Ext DCR protocols with only anterior flap suturing. Data collected include demographics, clinical presentations, primary diagnosis, associated systemic anomalies, past interventions, indications for the surgery, use of adjuvants, intraoperative and post-operative complications, aetiology of DCR failure, anatomical and functional successes...
May 24, 2018: Orbit
https://www.readbyqxmd.com/read/29792340/multidisciplinary-care-model-for-hiv-improves-treatment-outcome-a-single-centre-experience-from-the-middle-east
#10
Ali Elgalib, Halima Al-Sawafi, Bina Kamble, Saud Al-Harthy, Qamra Al-Sariri
Multidisciplinary team (MDT) care models have been shown to improve clinical outcomes among HIV patients. We aim to assess the impact of adopting MDT approach in a tertiary HIV clinic in Muscat, Sultanate of Oman. We introduced MDT approach in our HIV centre in January 2016 where existing team members (counsellors, nurses, social workers, pharmacists and doctors) worked together, through care pathways, to support patients as they go through the HIV care continuum from diagnosis to viral suppression. Notes were reviewed for demographics and clinical data...
May 24, 2018: AIDS Care
https://www.readbyqxmd.com/read/29792144/biomedical-applications-of-aromatic-azo-compounds-from-chromophore-to-pharmacophore
#11
Yousaf Ali, Shafida Abd Hamid, Umer Rashid
Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, biological properties of certain azo compounds including antibacterial, antiviral, antifungal and cytotoxic are also reported. Azo compounds can be used as drug carriers, either by acting as a 'cargo' that entrap therapeutic agents or by prodrug approach. The drug is released by internal or external stimuli in the region of interest, as observed in colon-targeted drug delivery...
May 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29792123/user-acceptance-of-an-app-based-adherence-intervention-perspectives-from-patients-taking-oral-anticancer-medications
#12
Eskinder Eshetu Ali, Sharlene Si Ling Chan, Jo Lene Leow, Lita Chew, Kevin Yi-Lwern Yap
Background Widespread adoption by patients is imperative for the success of app-based interventions for enhancing adherence to oral anticancer medications. Patients' attitudes and beliefs should be evaluated to understand determinants of their acceptance and adoption of such interventions. Objective To identify factors that influence cancer patients' intention to adopt an app-based system for enhancing oral anticancer medication adherence. Methods This study was conducted as part of the usability evaluation of an app-based system for enhancing adherence...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29791945/global-health-epilepsy
#13
Amza Ali
Epilepsy is a frequently misunderstood and highly stigmatized condition. Major treatment gaps exist across the world, most so in areas of financial constraint. Classification permits the best approaches to treatment and to ascertaining prognosis. The International League Against Epilepsy's new classification system emphasizes clinical aspects and utilizes all available resources to determine whether it is a focal or generalized epilepsy. The most important tools are a careful history, clinical examination, electroencephalography, and appropriate neuroimaging...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791936/is-right-sleeve-lower-lobectomy-necessary-is-it-safe
#14
Celalettin Ibrahim Kocaturk, Ozkan Saydam, Celal Bugra Sezen, Cem Emrah Kalafat, Levent Cansever, Ali Cevat Kutluk, Hasan Akin, Muzaffer Metin
OBJECTIVES:  The right sleeve lower lobectomy is the least used of the bronchial sleeve operations. There are only case-based studies in the literature. In this study, we compared this technique to those used in patients who underwent a right lower bilobectomy. METHODS:  We retrospectively reviewed the data of patients who had been operated on due to non-small cell lung cancer (NSCLC) from January 2005 to December 2015 from a dataset that was formed prospectively...
May 23, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29791876/extraction-and-characterization-of-cashew-tree-anacardium-occidentale-gum-use-in-aceclofenac-dental-pastes
#15
M Saquib Hasnain, Poonam Rishishwar, Sanjay Rishishwar, Sadath Ali, Amit Kumar Nayak
In the current work, the usefulness of extracted cashew tree gum (CG) as pharmaceutical excipient in dental pastes containing AC (for the pain management in the periodontitis) was investigated. CG was extracted from crude exudate of cashew tree (Anacardium occidentale, family: Anacardiaceae) (yield 19.22%). Physicochemical characteristics like colour, odour, taste, solubility, pH and viscosity of extracted CG were estimated; the phytochemical identification tests indicated the presence of carbohydrates and mucilage within it...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29791874/fabrication-of-electrospun-poly-vinyl-alcohol-dextran-nanofibers-via-emulsion-process-as-drug-delivery-system-kinetics-and-in-vitro-release-study
#16
A Meera Moydeen, M Syed Ali Padusha, Eman F Aboelfetoh, Salem S Al-Deyab, Mohamed H El-Newehy
A green method was used for the fabrication of coaxial nanofibers for use in biomedical applications. Coaxial nanofiber mats were fabricated by emulsion electrospinning from poly(vinyl alcohol) (PVA) and Dextran sulfate (Dex) blends loaded with ciprofloxacin (Cipro) as a model drug dissolved in edible oil. The ratio of the PVA/Dex mixture was optimized and nanofibers were stabilized against disintegration in water by thermal treatment at 120 °C. The morphology of the prepared nanofibers was observed by scanning electron microscopy and the structure of the core-shell nanofibers was confirmed by transmission electron microscopy...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29791793/assays-for-nucleotide-competitive-reversible-and-irreversible-inhibitors-of-ras-gtpases
#17
Sadasivam Jeganathan, Matthias Philipp Müller, Ali Imtiaz, Roger S Goody
Although the Ras protein has been seen as a potential target for cancer therapy for the past 30 years, there was a tendency to consider it undruggable until recently. This has changed with the demonstration that small molecules with specifcity for (disease related mutants of) Ras can indeed be found, and some of these molecules form covalent adducts. A subgroup of these molecules can be characterized as competing with binding of the natural ligands GTP and GDP. Because of the distinct properties of Ras and related GTPases, in particular the very high nucleotide affinities and associated very low dissociation rates, assays for characterizing such molecules are not trivial...
May 23, 2018: Biochemistry
https://www.readbyqxmd.com/read/29791694/filling-open-screw-holes-in-the-area-of-metaphyseal-comminution-does-not-affect-fatigue-life-of-the-synthes-variable-angle-distal-femoral-locking-plate-in-the-ao-ota-33-a3-fracture-model
#18
Luis Grau, Kevin Collon, Ali Alhandi, David Kaimrajh, Maria Varon, Loren Latta, Fernando Vilella
INTRODUCTION: The aim of this study is to evaluate the biomechanical effect of filling locking variable angle (VA) screw holes at the area of metaphyseal fracture comminution in a Sawbones® (Sawbones USA, Vashon, Washington) model (AO/OTA 33A-3 fracture) using a Synthes VA locking compression plate (LCP) (Depuy Synthes, Warsaw, Indiana). MATERIALS AND METHODS: Seven Sawbones® femur models had a Synthes VA-LCP placed as indicated by the manufacturers technique...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791609/association-between-multidrug-resistance-1-c3435t-gene-polymorphism-and-right-ventricular-dysfunction-in-patients-with-chronic-obstructive-pulmonary-disease-cross-sectional-study
#19
Oğuzhan Yücel, Hakan Güneş, Hasan Yücel, Ali Zorlu
BACKGROUND: Right ventricular (RV) dysfunction may develop over the course of chronic obstructive pulmonary disease (COPD) and is an important predictor of morbidity and mortality. Polymorphism of the multidrug resistance-1 (MDR-1) gene has been correlated with worse clinical findings among patients with COPD. Our aim here was to investigate the relationship between MDR-1 C3435T gene polymorphism and RV dysfunction in COPD patients. DESIGN AND SETTING: This was a cross-sectional study investigating the relationship between RV dysfunction and genetic defects in COPD patients...
March 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29791498/a-systematic-approach-to-parameter-selection-for-cad-virtual-reality-data-translation-using-response-surface-methodology-and-moga-ii
#20
Mustufa Haider Abidi, Abdulrahman Al-Ahmari, Ali Ahmad
Advanced graphics capabilities have enabled the use of virtual reality as an efficient design technique. The integration of virtual reality in the design phase still faces impediment because of issues linked to the integration of CAD and virtual reality software. A set of empirical tests using the selected conversion parameters was found to yield properly represented virtual reality models. The reduced model yields an R-sq (pred) value of 72.71% and an R-sq (adjusted) value of 86.64%, indicating that 86.64% of the response variability can be explained by the model...
2018: PloS One
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