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Keywords Compounding in dermatological ...

Compounding in dermatological therapy

https://read.qxmd.com/read/38500297/two-case-studies-of-persistent-white-hair-regrowth-after-alopecia-areata-turning-pigmented-following-treatment
#1
JOURNAL ARTICLE
Ziyuan Tian, Qingwu Liu, Ying Wang, Dingquan Yang
BACKGROUND: There is a strong correlation between alopecia areata (AA) and the development of white hair. The AA presents itself in many clinical manifestations of depigmented hair as the condition advances. It is uncommon for unpigmented hair to extensively regrow for more than one hair growth cycle in AA and successful conversion to pigmented hair after treatment has not yet been reported. AIM: We report two case studies involving the persistent regrowth of white hair after AA that became pigmented through treatment...
March 18, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38493799/resolution-of-painful-trichodysplasia-spinulosa-with-topical-cidofovir-case-report
#2
JOURNAL ARTICLE
Kevin M Burningham, Ritu N Swali, Peter L Rady, Anisha B Patel, Stephen K Tyring
Purpose: Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition which presents with widespread asymptomatic or pruritic, skin-colored papules with white protruding keratin spiculations in immunocompromised individuals. Due to its rarity, there is little data to guide treatment decisions. The purpose of this article is to report a case of TS that completely resolved after treatment with topical cidofovir. Materials and methods: A 19-year-old immunosuppressed female presented with widespread painful, itchy bumps on the nose and face...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38489090/a-case-of-bloom-syndrome-manifesting-with-therapy-related-myelodysplastic-syndromes-harboring-a-novel-blm-gene-variant
#3
JOURNAL ARTICLE
Takuma Ohashi, Hiroyoshi Kunimoto, Jun Nukui, Haruka Teshigawara, Satoshi Koyama, Takuya Miyazaki, Maki Hagihara, Kenji Matsumoto, Eriko Koshimizu, Naomi Tsuchida, Haruka Hamanoue, Satoko Miyatake, Akihiro Yachie, Naomichi Matsumoto, Hideaki Nakajima
Bloom syndrome (BS) is an autosomal recessive genetic disorder caused by variants in the BLM gene. BS is characterized by distinct facial features, elongated limbs, and various dermatological complications including photosensitivity, poikiloderma, and telangiectatic erythema. The BLM gene encodes a RecQ helicase critical for genome maintenance, stability, and repair, and a deficiency in functional BLM protein leads to genomic instability and high predisposition to various types of cancers, particularly hematological and gastrointestinal malignancies...
March 15, 2024: International Journal of Hematology
https://read.qxmd.com/read/38459626/stop-codon-readthrough-as-a-treatment-option-for-epidermolysis-bullosa-where-we-are-and-where-we-are-going
#4
REVIEW
Johanna Zandanell, Michael Wießner, Johann W Bauer, Roland N Wagner
In the context of rare genetic diseases caused by nonsense mutations, the concept of induced stop codon readthrough (SCR) represents an attractive avenue in the ongoing search for improved treatment options. Epidermolysis bullosa (EB)-exemplary for this group of diseases-describes a diverse group of rare, blistering genodermatoses. Characterized by extreme skin fragility upon minor mechanical trauma, the most severe forms often result from nonsense mutations that lead to premature translation termination and loss of function of essential proteins at the dermo-epidermal junction...
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38366625/intravenous-gentamicin-therapy-induces-functional-type-vii-collagen-in-recessive-dystrophic-epidermolysis-bullosa-patients-an-open-label-clinical-trial
#5
JOURNAL ARTICLE
David T Woodley, Michelle Hao, Andrew Kwong, Brandon Levian, Jon Cogan, Yingping Hou, Daniel Mosallaei, Elana Kleinman, Kate Zheng, Claire Chung, Gene Kim, David Peng, Mei Chen
BACKGROUND: Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable widespread blistering skin disorder caused by mutations in the gene encoding for type VII collagen (C7), the major component of anchoring fibrils. OBJECTIVE: To evaluate the efficacy and safety of intravenous (IV) gentamicin-readthrough therapy in patients with RDEB harboring nonsense mutations. Primary outcomes were increased expression of C7 in patients' skin and assessments for safety (ototoxicity, nephrotoxicity, autoimmune response)...
February 16, 2024: British Journal of Dermatology
https://read.qxmd.com/read/38332665/vitamin-c-lactoferrin-and-elastin-advancing-the-science
#6
JOURNAL ARTICLE
Alan D Widgerow, Mary E Ziegler
BACKGROUND: This study follows an initial scientific validation linking sodium ascorbate (SAC) with elastin conservation and the clinical trial histology observation that the full formulation tested there stimulated elastin development. In an effort to explain the increased elastin response, a candidate was sought that may provide synergy to SAC during elastin stimulation. Lactoferrin was the constituent chosen to explore in this realm. MATERIALS AND METHODS: Using the previously described ex vivo skin model, freshly collected discarded human skin from 2 donors was used to evaluate the effects of lactoferrin and SAC alone and together, and L-ascorbate CE Ferulic formulation (CEF) on elastogenesis...
February 8, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38299565/a-virtual-insight-into-mushroom-secondary-metabolites-3d-qsar-docking-pharmacophore-based-analysis-and-molecular-modeling-to-analyze-their-anti-breast-cancer-potential
#7
JOURNAL ARTICLE
Nusrat Shafiq, Bushra Shakoor, Nazia Yaqoob, Shagufta Parveen, Simone Brogi, Ahmad Mohammad Salamatullah, Maryam Rashid, Mohammed Bourhia
Breast cancer is a major issue of investigation in drug discovery due to its rising frequency and global dominance. Plants are significant natural sources for the development of novel medications and therapies. Medicinal mushrooms have many biological response modifiers and are used for the treatment of many physical illnesses. In this research, a database of 89 macro-molecules with anti-breast cancer activity, which were previously isolated from the mushrooms in literature, has been selected for the three-dimensional quantitative structure-activity relationships (3D-QSAR) studies...
February 1, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38248322/bitter-phytochemicals-as-novel-candidates-for-skin-disease-treatment
#8
REVIEW
Teodora-Cristiana Grădinaru, Adelina Vlad, Marilena Gilca
Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates for certain dermatological conditions, there remains a stringent demand for new remedies. Nature has long served as an inspiration for drug development. Recent studies have identified bitter taste receptors (TAS2Rs) in both skin cell lines and human skin. Additionally, bitter natural compounds have shown promising benefits in addressing skin aging, wound healing, inflammatory skin conditions, and even skin cancer...
December 30, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/38214440/revitalizing-the-skin-exploring-the-role-of-barrier-repair-moisturizers
#9
REVIEW
Nina Madnani, Jyotsna Deo, Krunal Dalal, Brian Benjamin, Vidya V Murthy, Rashmi Hegde, Tanvi Shetty
BACKGROUND: Moisturizers are designed to maintain skin health and treat dermatological conditions associated with impaired skin barrier function. However, differences in their composition account for the differences in their effect. AIMS: This narrative review aims to discuss the role of barrier repair moisturizers, highlight the role of different components in a moisturizer and their role in impaired skin conditions (e.g., dry, itchy, inflamed, sensitive skin, atopic eczema), and thereby empower dermatologists and pediatricians in selecting the right moisturizer...
January 12, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38180134/trifluridine-for-treatment-of-mpox-infection-in-drug-combinations-in-ophthalmic-cell-models
#10
JOURNAL ARTICLE
Jindrich Cinatl, Marco Bechtel, Philipp Reus, Melanie Ott, Florian Rothweiler, Martin Michaelis, Sandra Ciesek, Denisa Bojkova
The Mpox virus can cause severe disease in the susceptible population with dermatologic and systemic manifestations. Furthermore, ophthalmic manifestations of mpox infection are well documented. Topical trifluridine (TFT) eye drops have been used for therapy of ophthalmic mpox infection in patients, however, its efficacy against mpox virus infection in this scenario has not been previously shown. In the present study, we have established ophthalmic cell models suitable for the infection with mpox virus. We show, that TFT is effective against a broad range of mpox isolates in conjunctival epithelial cells and keratocytes...
January 2024: Journal of Medical Virology
https://read.qxmd.com/read/38174823/morphea-like-discoid-lupus-erythematosus-in-a-patient-with-a-history-of-polyacrylamide-gel-injection-a-case-report
#11
JOURNAL ARTICLE
Saba Hasanzadeh, Mahsa Babaie, Azadeh Rakhshan, Sahar Dadkhahfar
BACKGROUND: Discoid lupus erythematosus (DLE) is an autoimmune disease with multifactor etiology which develops in genetically susceptible patients. Rarely, DLE lesions can mimic other connective tissue disorders such as morphea. The growing application of soft tissue fillers is associated with increasing complications. Some substances used for soft tissue augmentation such as silicon implants may trigger lupus erythematosus diseases. CASE REPORT: Here we report a case of morphea-like discoid lupus erythematosus developed several years after polyacrylamide dermal filler (PAAG) injection for facial rejuvenation...
January 4, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38166511/a-systematic-review-and-meta-analysis-of-efficacy-and-safety-of-compound-glycyrrhizin-combined-with-second-generation-non-sedated-antihistamine-for-the-treatment-of-chronic-urticaria
#12
REVIEW
Sijue Chen, Wei Cao, Xianjun Xiao, Lu Wang, Renhong Wan, Zihao Zou, Qian Yang, Ying Li
BACKGROUND: Chronic urticaria (CU) is a prevalent dermatologic disease that negatively affects life, current therapies remain suboptimal. Hence, there is an urgent need to identify effective and safe treatment. OBJECTIVE: Assess the efficacy and safety of compound glycyrrhizin (CG) combined with second-generation nonsedated antihistamine for the treatment of CU. METHODS: Nine databases were queried to screen RCTs related. Two reviewers independently assessed the risk of bias using Cochrane Collaboration...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38146634/the-role-of-the-immunaturna%C3%A2-complex-in-promoting-skin-immunity-and-its-regenerative-abilities-implications-for-antiaging-skincare
#13
JOURNAL ARTICLE
Joanna Michalina Jurek, Victoria Neymann
INTRODUCTION: Recent advancements in cosmetic science have ushered in a new era of skincare strategies, with a focus on utilizing natural bioactive ingredients to enhance skin health and combat premature aging. The skin, as the largest organ of human body, provides as a vital protective barrier against external hazards such as environmental pollutions, toxins, and radiation. However, intrinsic and extrinsic factors, including various types of radiation, reduced air quality, and increased exposure to pollutants, lead to an imbalance in the skin's immune system, significantly reducing the skin's ability to regenerate and accelerating skin aging...
December 26, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38130178/analysis-of-the-efficacy-of-blunt-separation-combined-with-uncrosslinked-sodium-hyaluronate-composite-solution-for-the-treatment-of-tear-trough-deformity-in-asians
#14
JOURNAL ARTICLE
Richeng Dong, Qingmei Jin, Jiahui Zhi, Meilin Jin, Yang Gao, Meilan Nan, Zhehu Jin, Chenglong Jin
BACKGROUND: Filling therapy is becoming increasingly popular for correcting tear trough deformities (TTD). However, its therapeutic effect and retention time are limited. AIMS: To improve the clinical efficacy and safety of TTD treatment in Asians, we used a blunt separation technique to break the adhesion site of periorbital subcutaneous tissue, and while repairing skin dermis after injury, it was combined with uncrosslinked hyaluronic acid compound solution to promote collagen regeneration and treat TTDs...
December 22, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38100124/dietary-supplementation-with-a-wheat-polar-lipid-complex-improves-skin-conditions-in-women-with-dry-skin-and-mild-to-moderate-skin-aging
#15
JOURNAL ARTICLE
Catherine Kern, Stéphanie Dudonné, Christine Garcia
BACKGROUND: Aging, menopause, and seasonal changes alter the lipid composition of the outermost skin layer, the stratum corneum, resulting in dry and itchy skin. AIMS: This clinical trial aimed at evaluating the effects of a wheat polar lipid complex (WPLC) on skin characteristics in women showing dry and wrinkled skin, investigating its effects in a subgroup of postmenopausal women, and assessing if benefits were maintained after supplementation. METHODS: Seventy-two women with dry and wrinkled skin were recruited in this double-blind, randomized, parallel-group study, and allocated to three groups of 24 subjects, each including at least 10 postmenopausal women...
December 15, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38019566/clinical-efficacy-of-nutritional-supplements-in-atopic-dermatitis-systematic-review
#16
REVIEW
Isaac Weber, Emily Woolhiser, Noah Keime, Margaret Wasvary, Madeline J Adelman, Torunn E Sivesind, Robert P Dellavalle
BACKGROUND: Atopic dermatitis (AD), also known as eczema, is a chronic inflammatory skin condition that presents with symptoms of intense pruritus, dryness, and erythema. Dissatisfaction with first-line therapies for AD, the desire to avoid steroids, and the extreme cost of effective biologics have created a demand for alternative treatment options such as oral vitamins and nutritional supplements. OBJECTIVE: The purpose of this review was to assess the effectiveness of oral nutritional supplements, pre- and probiotics, and vitamin deficiencies and supplements on AD symptomology and clinical course...
November 29, 2023: JMIR dermatology
https://read.qxmd.com/read/38010992/fat-transplant-amazing-growth-and-regeneration-of-cells-and-rebirth-with-the-miracle-of-fat-cells
#17
REVIEW
Zahra Hajimortezayi, Narges Daei, Nasim Gholizadeh, Mana Zakeri, Farah Alhili, Sajedeh Hasanzadeh, Arezoo Hormozi, Faezeh Ebrahimi, Majid Zamani
BACKGROUNDS AND OBJECTIVE: During fat transplantation, adipose tissue is removed from the body and injected into different areas under the skin. The goal of this review article is to look into the efficacy and applicability of fat transplantation in regenerative medicine and rejuvenation, including Nanofat, Microfat, and Millifat. METHODS: As a search strategy and study selection, we searched the PubMed and Medline databases until 2023 using related keywords (e...
November 27, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/37974526/antibacterial-and-antibiofilm-effects-of-camellia-oleifera-seed-dreg-extract-and-its-application-in-cosmetics
#18
JOURNAL ARTICLE
Tsung-Ming Yeh, Wei-Wen Sung, Wen-Ling Shih
BACKGROUND: Cosmetic care products contain a high proportion of water and nutrients. Therefore, preventing bacterial growth is an important issue to ensure product quality and safety. The application of antibacterial natural ingredients derived from plants is considered to have the potential to maintain product quality and reduce the use of chemicals in formulations. Additionally, chemically synthesized antiseptic and antibacterial agents are widely used in the industry at present. However, some preservative ingredients have been reported that may cause skin irritation, redness, allergies, and even dermatitis...
November 16, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/37896042/polyphenols-from-mediterranean-plants-biological-activities-for-skin-photoprotection-in-atopic-dermatitis-psoriasis-and-chronic-urticaria
#19
REVIEW
Eleonora Di Salvo, Sebastiano Gangemi, Claudia Genovese, Nicola Cicero, Marco Casciaro
Polyphenols are a diverse class of natural compounds that are widely distributed in various fruits, vegetables, and herbs. They possess antioxidant and anti-inflammatory properties and bring benefits in the prevention and treatment of various diseases. Studies suggested that polyphenols may improve cardiovascular health and may have neuroprotective effects. The Mediterranean region is a vast area. Although the territory encompasses a wide variety of cultures and dietary patterns, there are some commonalities in terms of the plant-based foods and their polyphenol content...
October 15, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37876381/exploring-the-potential-of-hesperidin-in-preventing-hypertrophic-scars-insights-from-a-rabbit-ear-model
#20
JOURNAL ARTICLE
Ping Yang, JianBo Zhong, XingYun Zhao, Kamran Ali, Liming Wu, ZhangYu Bu
BACKGROUND: Hypertrophic scars, commonly occurring after trauma or surgery in critical areas like the head and joints, pose significant challenges to both physical and mental health due to their impact on skin function and aesthetics. While the complex pathogenesis involves fibroblast activation and collagen deposition, effective treatments are lacking, underscoring the importance of exploring pathogenesis and targeted therapies. Hesperidin, a bioactive compound in citrus fruits with diverse health benefits, including anti-fibrotic and anti-angiogenic effects, is the focus of this study with the aim of investigating its impact on hypertrophic scar formation, given its potential to promote blood flow and improve skin microcirculation...
2023: Clinical, Cosmetic and Investigational Dermatology
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