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Compounding in dermatological therapy

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https://www.readbyqxmd.com/read/29154501/challenges-to-laser-assisted-drug-delivery-applying-theory-to-clinical-practice
#1
Omer Ibrahim, Emily Wenande, Sara Hogan, Kenneth A Arndt, Merete Haedersdal, Jeffrey S Dover
BACKGROUND: The percutaneous penetration of topically applied compounds can be enhanced using external chemical or physical sources and thus laser-assisted drug delivery is a burgeoning area of interest within the field of dermatology. OBJECTIVES: This article briefly discusses the mechanism of laser-assisted drug delivery and expands upon the challenges and safety issues that may arise in the clinical implementation of this modality. RESULTS: The existing literature demonstrates that investigators and clinicians in dermatology have successfully delivered anti-inflammatory, anti-neoplastic, and anti-oxidative medications transdermally for the treatment of a variety of conditions including scarring, photoageing, and cutaneous neoplasia...
November 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#2
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28845183/efficacy-of-topical-compound-danxiong-granules-for-treatment-of-dermatologic-toxicities-induced-by-targeted-anticancer-therapy-a-randomized-double-blind-placebo-controlled-trial
#3
Aiping Tian, Aiping Zhou, Xinyu Bi, Shangying Hu, Zhichao Jiang, Wen Zhang, Zhen Huang, Hongzhe Shi, Boyan Yang, Wei Chen
Dermatologic toxicities resulting in dose reduction or discontinuation of treatment pose challenges for targeted anticancer therapies. We conducted this randomized, double-blind, placebo-controlled trial to investigate the efficacy of topical application of Compound Danxiong Granules (CDG) for treatment of dermatologic toxicities associated with targeted anticancer therapies. One hundred and ten patients with dermatologic toxicities induced by targeted anticancer therapies were randomly assigned to CDG or placebo group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28789577/utility-of-boron-in-dermatology
#4
David G Jackson, Leah A Cardwell, Elias Oussedik, Steven R Feldman
INTRODUCTION: Boron compounds are being investigated as therapies for dermatologic conditions. Several features of boron chemistry make this element an ideal component in dermatologic treatments. We review the published dermatologically-relevant clinical trials and case studies pertaining to boron compounds. METHODS: PubMed was utilized to query terms boron, chemistry, drug, development, dermatology, atopic dermatitis, psoriasis, onychomycosis, tavaborole, AN 2690, crisaborole, and AN 2728...
August 9, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28707186/natural-oils-for-skin-barrier-repair-ancient-compounds-now-backed-by-modern-science
#5
REVIEW
Alexandra R Vaughn, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
Natural plant oils are commonly used as topical therapy worldwide. They are usually easily accessible and are relatively inexpensive options for skin care. Many natural oils possess specific compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-itch properties, making them attractive alternative and complementary treatments for xerotic and inflammatory dermatoses associated with skin-barrier disruption. Unique characteristics of various oils are important when considering their use for topical skin care...
July 13, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28689207/design-of-finasteride-loaded-nanoparticles-for-potential-treatment-of-alopecia
#6
Luís V Roque, Inês S Dias, Nuno Cruz, Ana Rebelo, Amílcar Roberto, Patrícia Rijo, Catarina P Reis
BACKGROUND/AIMS: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with poor aqueous solubility, blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT) in a significant reduction in DHT concentration, achieving satisfactory results in alopecia treatment. However, its oral intake generally causes severe side effects. Considering that there is currently no scientifically proven treatment, new drug delivery systems able to improve alopecia therapy are urgently required...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28617319/pde4-inhibition-and-inflammatory-bowel-disease-a-novel-therapeutic-avenue
#7
REVIEW
Marco Spadaccini, Silvia D'Alessio, Laurent Peyrin-Biroulet, Silvio Danese
BACKGROUND: In the last few decades, a better knowledge of the inflammatory pathways involved in the pathogenesis of Inflammatory Bowel Disease (IBD) has promoted biological therapy as an important tool to treat IBD patients. However, in spite of a wider spectrum of biological drugs, a significant proportion of patients is unaffected by or lose their response to these compounds, along with increased risks of infections and malignancies. For these reasons there is an urgent need to look for new pharmacological targets...
June 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28530733/photophysical-properties-singlet-oxygen-generation-efficiency-and-cytotoxic-effects-of-aloe-emodin-as-a-blue-light-photosensitizer-for-photodynamic-therapy-in-dermatological-treatment
#8
Lixin Zang, Huimin Zhao, Xueyu Ji, Wenwu Cao, Zhiguo Zhang, Peisong Meng
Conventional photodynamic therapy (PDT) uses red light for deeper penetration. A natural compound, aloe emodin (AE) with anticancer and photosensitising capabilities, excited by blue light, is proposed to treat superficial diseases. The photophysical properties and singlet oxygen quantum yield (ΦΔ) of AE, as well as the cytotoxic effects of AE on human cells, were investigated. The absorption and emission spectra of AE were analyzed. The ΦΔ of AE was measured by a relative method. In order to study the relationship between ΦΔ and the oxygen concentration, the dependence of ΦΔ on the oxygen concentration was investigated...
July 1, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28469834/ibrutinib-associated-skin-toxicity-a-case-of-maculopapular-rash-in-a-79-year-old-caucasian-male-patient-with-relapsed-waldenstrom-s-macroglobulinemia-and-review-of-the-literature
#9
Anders Bisgaard Jensen, Birgitte Stausbøl-Grøn, Rikke Riber-Hansen, Francesco d'Amore
Waldenstrom's macroglobulinamia (WM) is a rare malignant lymphoproliferative disorder, characterized by monoclonal IgM paraproteinemia and neoplastic proliferation of malignant lymphoplasmacytoid cells in the bone marrow. Traditionally, WM has been treated with modalities similar to those used in the management of other indolent lymphomas. Just recently, based on impressive clinical trial results in heavily pretreated WM patients, a new Bruton Tyrosine Kinase-inhibitor, Ibrutinib, has been approved for the treatment of this disorder...
March 13, 2017: Dermatology Reports
https://www.readbyqxmd.com/read/28134705/cutaneous-manifestations-of-systemic-viral-diseases-in-neonates-an-update
#10
Stephanie A Castillo, Anh Khoa Pham, James G Dinulos
PURPOSE OF REVIEW: Dermatologic findings may be the first signs of a neonatal viral infection. This review provides an update of the diagnostic features and therapies for selected viral illnesses [herpes simplex virus (HSV), varicella zoster virus, enterovirus, and Zika virus] that present with cutaneous manifestations in the neonate. RECENT FINDINGS: HSV DNA polymerase chain reaction of plasma and cerebrospinal fluid, routinely used in the diagnosis of neonatal HSV, may have expanded utility in assessing prognosis and acyclovir therapeutic efficacy...
April 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28128086/vesicular-contact-reaction-may-progress-into-erythema-multiforme
#11
REVIEW
Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Joanna Szulczyńska-Gabor, Ewa Teresiak-Mikołajczak, Joanna Szyfter-Harris, Monika Bowszyc-Dmochowska
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. This type of cutaneous reaction is associated with inflammation manifesting with erythema, edema, and vesicles...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27868472/topical-and-systemic-antifungals-in-dermatology-practice
#12
Murat Durdu, Macit Ilkit, Yalda Tamadon, Ali Tolooe, Haleh Rafati, Seyedmojtaba Seyedmousavi
Dermatophytosis is generally defined as an infection of the hair, nails, or glabrous skin. These infections are caused by the keratinophilic fungi Trichophyton spp., Microsporum spp., and Epidermophyton, which have been recovered from both symptomatic and asymptomatic individuals. Although dermatophytosis is generally not a life-threatening condition, these types of infections are among the most common infections worldwide, and their incidence has continued to increase consistently in recent years. Area covered: This article provides an overview of the general characteristics of dermatophytes, including their taxonomy and epidemiology, as well as the different clinical forms and laboratory diagnostics of dermatophytosis...
February 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27749251/side-effects-of-retinoid-therapy-on-the-quality-of-vision
#13
REVIEW
Beata Bergler-Czop, Monika Bilewicz-Stebel, Anna Stańkowska, Teresa Bilewicz-Wyrozumska
Retinoids are compounds chemically related to vitamin A, which are frequently used in dermatological practice (1). They are characterized by numerous mechanisms of action leading to normalization of keratinocyte proliferation and maturation. They have anti-seborrhoeic, immunomodulatory and anti-inflammatory effects (1, 2). A number of side effects to retinoid treatment have been recorded; one group of such side effects relates to eyes and vision. Dry eye syndrome and blepharoconjunctivitis are the most common side effects, appearing in 20-50 % of patients treated with retinoids...
December 1, 2016: Acta Pharmaceutica
https://www.readbyqxmd.com/read/27578074/itch-management-treatments-under-development
#14
REVIEW
Manuel Pedro Pereira, Sonja Ständer
Pruritus is a symptom arising from a plethora of dermatological, neurological, and systemic conditions. The pathophysiological mechanisms involved in the transmission of acute and chronic pruritus are of high complexity and not yet fully understood. Recent research has enhanced the understanding of these mechanisms, enabling the development of novel drugs. Specifically, new therapies for inflammatory dermatoses, uremic pruritus, cholestatic pruritus, cutaneous T-cell lymphoma, and prurigo nodularis are being tested in ongoing randomized clinical trials...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27079364/toxic-epidermal-necrolysis-13-years-of-experience-in-the-management-at-a-department-of-dermatology-in-china
#15
Feng Zhang, Jin Zhou
OBJECTIVE: The study aimed to investigate the efficacy of our therapeutic options on toxic epidermal necrolysis (TEN) patients. METHODS: After giving informed consent, patients affected by TEN were included in the study between January 2001 and December 2013. Suspected causative drugs, onset to hospitalization, complications, management, outcome, laboratory investigations of blood tests and therapeutic options were recorded and analyzed. SCORTEN scoring system was used to evaluate the complications and the survival rate...
March 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/26808004/target-oriented-therapy-emerging-drugs-for-atopic-dermatitis
#16
REVIEW
Felix Lauffer, Johannes Ring
INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a life-time prevalence of 10 - 20% in western countries. Patients suffer from stigmatizing eczematous skin lesions, persisting itch and sleep disorders. Starting usually in early childhood the course of AD is heterogeneous. While most frequently AD disappears before adolescence, about 30% of patients show a chronic persisting course. There is an urgent need for new therapeutic options as until now, specific drugs are missing...
2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/26583648/optimizing-care-and-compliance-for-the-treatment-of-mycosis-fungoides-cutaneous-t-cell-lymphoma-with-mechlorethamine-gel
#17
Allister Benjamin Chase, Kristen Markel, Marianne C Tawa
BACKGROUND: Mycosis fungoides is the most common form of cutaneous T-cell lymphoma (MF-CTCL). Quality nursing care is necessary for effective diagnosis and treatment of patients with MF-CTCL. Early-stage MF-CTCL (stages Ia and Ib) is most often managed in both dermatology and multidisciplinary settings. These stages can be effectively controlled by skin-directed therapies such as mechlorethamine gel (Valchlor®). Topical mechlorethamine has been used since the 1940s as an alkylating agent; however, compounded formulas have disadvantages that limit patient compliance...
December 2015: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/26559433/nanotechnology-based-photodynamic-therapy-concepts-advances-and-perspectives
#18
REVIEW
Tarun Garg, Nitin K Jain, Goutam Rath, Amit Kumar Goyal
Photodynamic therapy (PDT) is a photoactive process that uses the combination of photosensitizers (PSs) and specific wavelengths of light for the treatment of solid tumors and other diseases. PDT received increased attention after regulatory approval of several photosensitizing drugs and light applicators worldwide. With the advent of newer PSs, the role of PDT in the treatment of cancer and other diseases has been revolutionized. In addition, various targeting strategies developed for site-specific delivery of PSs will be helpful for avoiding phototoxicity to normal tissues...
2015: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/26167724/exploiting-metalloporphyrins-for-selective-living-radical-polymerization-tunable-over-visible-wavelengths
#19
Sivaprakash Shanmugam, Jiangtao Xu, Cyrille Boyer
The use of metalloporphyrins has been gaining popularity particularly in the area of medicine concerning sensitizers for the treatment of cancer and dermatological diseases through photodynamic therapy (PDT), and advanced materials for engineering molecular antenna for harvesting solar energy. In line with the myriad functions of metalloporphyrins, we investigated their capability for photoinduced living polymerization under visible light irradiation over a broad range of wavelengths. We discovered that zinc porphyrins (i...
July 22, 2015: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/25496805/design-synthesis-and-biological-activity-of-a-novel-rutin-analogue-with-improved-lipid-soluble-properties
#20
Anna Baldisserotto, Silvia Vertuani, Alessia Bino, Daniela De Lucia, Ilaria Lampronti, Roberta Milani, Roberto Gambari, Stefano Manfredini
Recent interest in flavonoids has increased greatly due to their biological and pharmacological activities. Flavonoids, consist of a large group of low molecular weight polyphenolic substances, naturally occurring in fruits, vegetables, tea, and wine, and are an integral part of the human diet. Rutin is a common dietary flavonoid that is widely consumed worldwide from plant-derived beverages and foods as traditional and folk medicine remedy as well. Rutin exhibit important pharmacological activities, including anti-oxidation, anti-inflammation, anti-diabetic, anti-adipogenic, neuroprotective and hormone therapy...
January 1, 2015: Bioorganic & Medicinal Chemistry
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