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Alzhaimer

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https://www.readbyqxmd.com/read/24369244/-expression-of-stat3-and-p-stat3-in-the-brain-of-a-transgenic-mouse-model-of-alzheimer-s-disease
#1
Mi Tian, Deren Hou, Yanyao Deng, Wei Li, Xialu Feng
OBJECTIVE: To detect the expression of signal transducer and activator of transcription 3 (STAT3) and P-STAT3 in the brain of the APPswe/PS δE9 double transgenic mouse model of Alzhaimer's disease (AD) and investigate their possible role in AD. METHODS: APPswe/PS δE9 double transgenic mice and control mice were examined for cerebral STAT3 and P-STAT3 expressions using immunothistochemistry. RESULTS: STAT3 and P-STAT3 were expressed in the different regions of mouse brain...
December 2013: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/23443785/-real-time-pcr-for-detecting-differential-expressions-of-micrornas-in-the-brain-of-a-transgenic-mouse-model-of-alzheimer-s-disease
#2
Mi Tian, Yu Ding, Deren Hou, Yanyao Deng, Wei Li, Xialu Feng
OBJECTIVE: To detect the expression of miRNA-135a-5p, miRNA-135a-2-3p, miRNA-298-5p, miRNA-466b-3p and miR-669f-3p in the brain tissue of the APPswe/PS δE9 double transgenic mouse model of Alzhaimer's disease using real-time PCR. METHODS: Six-month-old APPswe/PS δE9 double transgenic mice and wild-type C57 mice of the same species were examined for the expressions of miRNA-135a-5p, miRNA-135a-2-3p, miRNA-298-5p, miRNA-466b-3p and miR-669f-3p in the brain tissue using real-time PCR...
February 2013: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/21993346/aluminum-induced-oxidative-stress-and-neurotoxicity-in-grass-carp-cyprinidae-ctenopharingodon-idella
#3
María Lourdes Fernández-Dávila, Amparo Celene Razo-Estrada, Sandra García-Medina, Leobardo Manuel Gómez-Oliván, Manuel Jesús Piñón-López, Rocio Guzmán Ibarra, Marcela Galar-Martínez
Aluminum is used in a large number of anthropogenic processes, leading to aquatic ecosystems pollution. Diverse studies show that in mammals this metal may produce oxidative stress, is neurotoxic, and is involved in the development of neurodegenerative disorders, such as Alzhaimer's and Parkinson's diseases. Nevertheless, there are only few studies with respect to Al-induced neurotoxicity on aquatic fauna, particularly on fishes of economical interest, such as the grass carp (Ctenopharingodon idella). This study evaluates Al-induced toxicity on the grass carp C...
February 2012: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/16119642/preparation-the-family-to-care-of-the-patient-with-alzhaimer-s-disease
#4
M Cisek, E Wilczek-Ruzyczka, A Gniadek, A Zdanowska
PURPOSE: Evaluation of the level of the family readiness to look after a person suffering from the Alzheimer's disease. MATERIAL AND METHODS: In the research an authorized questionnaire was used, which comprised knowledge concerning the disease, coping with the situation, looking after a patient and an open test. RESULTS: It was shown that the level of knowledge about Alzheimer's disease corresponds to the level of education (p < 0.05)...
2005: Roczniki Akademii Medycznej W Białymstoku, Annales Academiae Medicae Bialostocensis
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