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https://read.qxmd.com/read/38496208/isolated-malignant-pleural-effusion-in-a-child-unusual-presentation-of-acute-leukemia
#1
Srinija Garlapati, Sampada Tambolkar, Sarita Verma, Nakul V Pathak, Manojkumar G Patil
Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non-infectious factors. Notably, Streptococcus pneumoniae stands out as the predominant infectious agent responsible for this condition. Non-infectious causative factors encompass hematolymphoid malignancies, congestive heart failure, hemothorax, hypoalbuminemia, and iatrogenic causes...
February 2024: Curēus
https://read.qxmd.com/read/38494390/mortality-risk-prediction-for-primary-appendiceal-cancer
#2
JOURNAL ARTICLE
Nolan M Winicki, Shannon N Radomski, Yusuf Ciftci, Ahmed H Sabit, Fabian M Johnston, Jonathan B Greer
BACKGROUND: Accurately predicting survival in patients with cancer is crucial for both clinical decision-making and patient counseling. The primary aim of this study was to generate the first machine-learning algorithm to predict the risk of mortality following the diagnosis of an appendiceal neoplasm. METHODS: Patients with primary appendiceal cancer in the Surveillance, Epidemiology, and End Results database from 2000 to 2019 were included. Patient demographics, tumor characteristics, and survival data were extracted from the Surveillance, Epidemiology, and End Results database...
March 16, 2024: Surgery
https://read.qxmd.com/read/38494292/paraneoplastic-neurologic-manifestations-of-neuroendocrine-tumors
#3
JOURNAL ARTICLE
Marco Zoccarato, Wolfgang Grisold
Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from the transformation of neuroendocrine cells in several organs, most notably the gastro-entero-pancreatic system and respiratory tract. The classification was recently revised in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. NENs can rarely spread to the central or peripheral nervous systems. Neurologic involvement is determined by the rare development of paraneoplastic syndromes, which are remote effects of cancer...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38492357/endobronchial-solitary-fibrous-tumors-an-enigma-for-diagnosis
#4
Fátima Ramalhosa, Federica Pezzuto, Francesco Fortarezza, Gianluca Canu, Davide Biondini, Eleonora Faccioli, Roberta Polverosi, Chiara Giraudo, Fiorella Calabrese
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms constituting less than 2% of all soft tissue tumors. They typically originate in the thoracic cavity, mainly in the pleura, but can also occur in other various sites such as lung parenchyma, pericardium, and bronchus. In this study, a 49-year-old non-smoking female with a history of allergies presented to our pulmonary clinic with a chronic cough. An explorative bronchoscopy revealed an intrabronchial mass in the left superior bronchi, and a 68 Ga-DOTATOC positron emission computed tomography suggested a carcinoid tumor...
March 4, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38490884/factors-associated-with-long-term-survival-in-children-with-bronchial-and-lung-carcinoid-tumors
#5
JOURNAL ARTICLE
Swathi R Raikot, Courtney N Day, R Paul Boesch, Wendy Allen-Rhoades, Stephanie F Polites
BACKGROUND AND AIMS: Bronchial carcinoids are rare in children and the treatment is based on tumor behavior in adults. The purpose of this study was to determine factors and management strategies associated with long-term survival in the pediatric population using a national cohort. METHODS: Patients aged ≤20 years with bronchial carcinoid tumors were identified in the 2004-2020 National Cancer Database using ICD-O-3 codes. Tumor characteristics and management were compared among typical (TC) and atypical (AC) histological subtypes using Chi-square and Fisher's exact tests...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38486845/pulmonary-endarterectomy-for-chronic-thromboembolic-pulmonary-hypertension-with-bronchial-obstruction-by-a-carcinoid-tumor
#6
Yuki Monden, Dai Une, Sho Mitsumune, Hiroto Shimokawahara, Hirofumi Okada, Kenji Yoshida, Shutaro Kato, Suzuka Kamaguchi, Mikizo Nakai, Motomi Ando
Pulmonary endarterectomy (PEA) is a standard treatment for chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH combined with bronchial obstruction by a tumor is rare but should be assessed carefully because PEA for obstructed segments can be less therapeutic and make the subsequent surgical resection challenging. This report describes a case of CTEPH with bronchial obstruction by a typical carcinoid tumor in a 75-year-old man. On-site evaluation and removal of the obstructive tumor were performed bronchoscopically, increasing the effectiveness of subsequent PEA for all affected pulmonary segments...
January 2024: Pulmonary Circulation
https://read.qxmd.com/read/38469365/benign-lymphoid-polyp-of-the-rectum-diagnosed-and-treated-with-endoscopic-submucosal-resection-with-a-ligation-device
#7
Tomoyuki Nishimura, Tomotaka Tanaka, Syohei Ishimaru, Keiko Arataki, Fumio Shimamoto
Benign lymphoid polyps of the rectum, also termed "Rectal tonsil" or "Pseudolymphoma," are submucosal tumor-like growths with localized hyperplasia of the lymphoid follicles and are often discovered incidentally during colonoscopy. Its diagnosis and differentiation from other submucosal tumors pose challenges owing to their similar endoscopic features. A 72-year-old woman presented with a positive fecal occult blood test, which led to the discovery of a 10-mm lower rectal tumor resembling a neuroendocrine tumor during colonoscopy...
March 2024: Curēus
https://read.qxmd.com/read/38466015/neurological-autoimmunity-in-patients-with-non-pulmonary-neuroendocrine-neoplasms-clinical-manifestations-and-neural-autoantibody-profiles
#8
JOURNAL ARTICLE
Georgios Mangioris, Thorvardur R Halfdanarson, Vanda A Lennon, Bryce K Chang, Divyanshu Dubey, P James B Dyck, Eoin P Flanagan, Andrew McKeon, John R Mills, Sean J Pittock, Anastasia Zekeridou
BACKGROUND AND PURPOSE: Paraneoplastic neurological autoimmunity is well described with small-cell lung cancer, but information is limited for other neuroendocrine neoplasms (NENs). METHODS: Adult patients with histopathologically confirmed non-pulmonary NENs, neurological autoimmunity within 5 years of NEN diagnosis, and neural antibody testing performed at the Mayo Clinic Neuroimmunology Laboratory (January 2008 to March 2023) were retrospectively identified...
March 11, 2024: European Journal of Neurology
https://read.qxmd.com/read/38455854/the-skin-as-a-window-to-the-gut-a-case-of-carcinoid-syndrome
#9
Catarina Alves Costa, Tânia Lopes, Ana Patrícia Rodrigues, Nuno Jorge Lamas, Célia Cruz
Neuroendocrine tumors (NETs) are a group of uncommon neoplasms derived from enterochromaffin or Kulchitsky cells (that secrete serotonin or other molecules into the bloodstream), which can manifest with symptoms of hormonal overproduction, namely carcinoid syndrome (CS). This can be the presenting feature in patients with advanced disease. We report the case of a 66-year-old woman presenting with chronic diarrhea, facial venous telangiectasia and elevated urinary 5-hydrocyindoleacetic acid levels. A 68-Ga DOTATOC PET/CT scan revealed an ileal mass and lesions consistent with liver, ovary and bone metastasis...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38445115/incidental-finding-of-well-differentiated-duodenal-neuroendocrine-tumor-on-diagnostic-upper-endoscopy
#10
Kelsey Lamb, Shiv B Gakhar, Suresh Jayatilaka
Neuroendocrine tumors (NETs) are rare and slow-growing. They are often found incidentally, and patients typically present with vague symptoms. This is a case report detailing an 83-year-old female who presents with signs and symptoms consistent with esophageal stricture and was incidentally found to have a duodenal NET. Treatment typically involves surgical removal and carries a good prognosis. With complete surgical resection of localized tumors, the chance of progression or recurrence is low.
February 2024: Curēus
https://read.qxmd.com/read/38444924/testicular-neuroendocrine-tumor-in-a-32-year-old-man-a-case-report
#11
Reza Dehghaniathar, Asaad Moradi, Nikoo Emtiazi
KEY CLINICAL MESSAGE: A 32-year-old male with painful scrotal swelling who underwent radical orchiectomy and was diagnosed with a testicular neuroendocrine tumor. Determining whether testicular neuroendocrine tumor is primary or metastasis from another origin is crucial. ABSTRACT: Testicular neuroendocrine tumors (TNET) are one of the rarest human neoplasms, with about 132 identified cases until 2015. Testicular neuroendocrine tumors are frequently manifest with painless scrotal swelling or mass...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38442781/pulmonary-gangliocytic-paraganglioma-an-under-recognized-mimic-of-carcinoid-tumor
#12
JOURNAL ARTICLE
Julia R Naso, Diping Wang, Arthur O Romero, Timothy Leclair, Peter Smit, Jennifer M Boland, Andrew L Folpe, Melanie C Bois
Gangliocytic paragangliomas are rare neoplasms occurring almost exclusively in the ampullary region of the gastrointestinal tract. Although these tumors are not typically considered in the differential diagnosis of primary pulmonary neoplasia, 5 cases of primary pulmonary gangliocytic paragangliomas have been previously reported. Herein we report our experience with 3 additional examples, all referred to our Anatomic Pathology Consultation service. The patients (a 32-year-old man, a 69-year-old woman and a 55-year-old man) each presented with an endobronchial (2 cases) or upper lobe lung mass, ranging from 1...
March 3, 2024: Human Pathology
https://read.qxmd.com/read/38434157/gallbladder-carcinoid-in-a-cat
#13
Tania Shaw
Carcinoids are rare tumors that originate from neuroendocrine system cells. There has apparently only been 1 report in the veterinary medical literature of a cat with a gallbladder carcinoid, with no long-term follow-up information available from that case. Furthermore, apparently only 9 dogs with gallbladder carcinoids have been reported, again with no long-term follow-up. This case report describes the clinical presentation, surgical appearance, histopathologic and immunohistochemical findings, postoperative adjuvant chemotherapy treatment, and long-term outcome of a domestic longhair cat with a gallbladder carcinoid...
March 2024: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/38433619/liver-transplant-for-primary-biliary-tract-neuroendocrine-tumor-in-a-nine-year-old-girl
#14
Anjali Rai, Lauren Sproule, Tatianna Larman, Kiyoko Oshima, Daniel Rhee, Kenneth Ng, Elizabeth King, Douglas Mogul, Kathryn Lemberg
BACKGROUND: Neuroendocrine tumors (NETs) are rare epithelial neoplasms that arise most commonly from the gastrointestinal tract. In pediatrics, the most common site of origin is in the appendix, with the liver being the most common site of metastasis. Neuroendocrine tumors arising from the biliary tract are extremely rare. METHODS: We describe a case of a nine-year-old girl who presented with obstructive cholestasis and was found to have multiple liver masses identified on biopsy as well-differentiated neuroendocrine tumor with an unknown primary tumor site...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38430900/diagnostic-and-therapeutic-challenges-of-a-rare-large-ovarian-strumal-carcinoid-in-pregnancy-about-a-case-report
#15
Fathi Mraihi, Jihene Basly, Zeineb Ghali, Eya Azouz, Asma Ayari, Dalenda Chelli
INTRODUCTION: Ovarian strumal carcinoid is a rare type of germ cell tumor. It usually affects perimenopausal and postmenopausal women. Very few cases of stromal carcinoid have been reported in the literature in women of childbearing age, particularly during pregnancy. The clinical presentation of the tumor, and in particular its non-specific clinical and radiological appearance and rarity, explain the difficulties in diagnosis and management. PRESENTATION OF CASE: Herein, we describe a rare case of a 36-year-old patient who was followed-up in our outpatient clinic for organic cyst of the ovary...
February 29, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38415487/unusual-breast-metastasis-from-atypical-lung-carcinoid-on-68ga-dotatate-pet-ct
#16
Berna Okudan, Bedri Seven, Aslıhan Yıldırım, Aynur Albayrak
BACKGROUND: Atypical carcinoid (AC) is one of the rarest lung neuroendocrine tumors (NETs) that rarely metastasize to the breast, and only a few cases have been reported in the literature. Positron emission tomography/computed tomography (PET/CT) with somatostatin analogs (SSAs) labeled with Gallium-68 (68Ga) now represents the gold standard for diagnosis and management of NETs. A case of an unusual metastasis to the breast from an AC detected by 68Ga-DOTATATE PET/CT was reported. CASE PRESENTATION: A 73-year-old woman was presented with a right breast lesion found on mammography screening, which revealed a metastatic neuroendocrine tumor by histopathological analysis with a tru-cut biopsy...
February 26, 2024: Current medical imaging
https://read.qxmd.com/read/38396713/does-telotristat-have-a-role-in-preventing-carcinoid-heart-disease
#17
JOURNAL ARTICLE
Aura D Herrera-Martínez, Antonio C Fuentes-Fayos, Rafael Sanchez-Sanchez, Antonio J Montero, André Sarmento-Cabral, María A Gálvez-Moreno, Manuel D Gahete, Raúl M Luque
Carcinoid heart disease (CHD) is a frequent and life-threatening complication in patients with carcinoid tumors. Its clinical management is challenging is some cases since serotonin-induced valve fibrosis leads to heart failure. Telotristat is an inhibitor of tryptophan-hydroxylase (TPH), a key enzyme in serotonin production. Telotristat use in patients with carcinoid syndrome and uncontrollable diarrhea under somatostatin analogs is approved, but its specific role in patients with CHD is still not clear. IN this context, we aimed to explore the effect of telotristat in heart fibrosis using a mouse model of serotonin-secreting metastasized neuroendocrine neoplasm (NEN)...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38392065/virtual-care-for-patients-with-advanced-well-differentiated-gastroenteropancreatic-neuroendocrine-tumor-gep-net
#18
JOURNAL ARTICLE
William J Phillips, Michelle Pradier, Rachel Goodwin, Michael Vickers, Tim Asmis
INTRODUCTION: The COVID-19 pandemic resulted in an unprecedent shift towards virtual cancer care, including the care of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The aim of this study was to evaluate the use of virtual care for GEP-NETs during the COVID-19 pandemic at a high-volume academic cancer center. METHODS: This retrospective, observational study performed at the Ottawa Hospital Cancer Center in Canada evaluated adult patients with GEP-NETs seen in consultation by medical oncology between 1 June 2019 and 31 December 2022...
February 8, 2024: Current Oncology
https://read.qxmd.com/read/38387372/jejunal-adenocarcinoma-a-case-report-and-literature-review
#19
Hamed Tahmasbi, Parvin Kashani, Alireza Haghbin Toutounchi, Shaghayegh Sadeghmousavi, Arman Hasanzade, Mohammad Aghaei
INTRODUCTION AND IMPORTANCE: Small bowel carcinoma (SBC) is a rare malignancy comprising mainly of adenocarcinoma and carcinoid tumors. Among SBCs, small bowel adenocarcinoma (SBA) accounts for 30-40 % and is predominantly found in the duodenum, while jejunal and ileal presence considered rare. CASE PRESENTATION: We have presented a case of jejunal adenocarcinoma in a patient with obstruction symptoms. Prior to the obstruction, the patient mainly suffered from weakness and weight loss, in addition to iron deficiency anemia...
February 14, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38383872/peritoneal-dissemination-of-appendiceal-goblet-cell-adenocarcinoma-mimicking-white-pus-caused-by-peritonitis-following-appendicitis-an-instructive-case-report
#20
JOURNAL ARTICLE
Keigo Nakashima, Masakazu Hashimoto, Yoshihito Kitamura, Makoto Shinohara, Mizuki Yamaguchi, Michinori Hamaoka, Masashi Miguchi, Toshihiro Misumi, Nobuaki Fujikuni, Satoshi Ikeda, Yasuhiro Matsugu, Takashi Nishisaka, Hideki Nakahara
BACKGROUND: Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis. CASE PRESENTATION: We report a case of goblet cell adenocarcinoma with peritoneal metastases. A 62-year-old man underwent appendectomy for acute appendicitis. Intraoperatively, inflammatory white pus and a small amount of dirty ascites were observed in the lower abdomen with severely inflamed appendix...
February 22, 2024: Surgical Case Reports
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