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https://www.readbyqxmd.com/read/29441166/a-case-of-madness-resulting-in-a-fortunate-outcome-case-report-of-a-psychotic-break-as-a-result-of-cortisol-secreting-thymic-neuroendocrine-thymic-tumor
#1
Jibran Durrani, Faizan Malik, Naveed Ali, Syed Imran Mustafa Jafri, Mohsin Hamid
Representing a mere 2-5% of the total thymic malignancies and 0.4% of total carcinoid tumors, primary thymic neuroendocrine tumors (NETs) are the zebras of the thymic neoplasms. They were initially characterized as 'epithelial thymomas'; later, the term carcinoid tumors was coined by Rosai and Higa. These tumors are highly unpredictable in their presentation and prognosis. Coupled with variable clinical presentation, rare pathologic diagnosis and absence of diagnostic and prognostic parameters, it is a challenge for both patients and clinicians...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29438170/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-dipnech-syndrome-and-carcinoid-tumors-with-without-nech-a-clinicopathologic-radiologic-and-immunomolecular-comparison-study
#2
Maria Cecilia Mengoli, Giulio Rossi, Alberto Cavazza, Renato Franco, Federica Zito Marino, Mario Migaldi, Letizia Gnetti, Enrico Maria Silini, Luca Ampollini, Marcello Tiseo, Filippo Lococo, Ludovic Fournel, Paolo Spagnolo, Vincent Cottin, Thomas V Colby
The diagnostic criteria of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) are not well defined, and DIPNECH can be mistaken for carcinoids associated with neuroendocrine cell hyperplasia (NECH). In this study, we compared clinical, radiologic, histologic, immunohistochemical, and molecular features of DIPNECH and isolated carcinoids with/without NECH. The study population included 151 cases (77 female patients and 74 male patients), 19 with DIPNECH and 132 with carcinoids with/without NECH...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29434915/immunohistochemical-cd73-expression-status-in-gastrointestinal-neuroendocrine-neoplasms-a-retrospective-study-of-136-patients
#3
Kohei Ono, Eisuke Shiozawa, Nobuyuki Ohike, Tomonori Fujii, Hideki Shibata, Tetsuya Kitajima, Koichiro Fujimasa, Naoko Okamoto, Yukiko Kawaguchi, Tasuku Nagumo, Sakiko Tazawa, Mayumi Homma, Toshiko Yamochi-Onizuka, Tomoko Norose, Hitoshi Yoshida, Masahiko Murakami, Gensyu Tate, Masafumi Takimoto
The WHO 2010 classification divides gastrointestinal neuroendocrine neoplasms (GI-NENs) into neuroendocrine tumor (NET) G1, NET G2, neuroendocrine carcinoma (NEC) and mixed adenoendocrine carcinoma (MANEC) groups. A total of 136 cases of GI-NENs diagnosed at our hospitals as gastrointestinal carcinoids, endocrine cell carcinomas and NENs over the last 11 years, using the WHO 2010 classification were assessed. Among the 136 cases, 88.2% (120/136) were classified into the NET group (NET G1/G2) and 11.8% (16/136) were classified into the NEC group (NEC/MANEC)...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433123/endobronchial-treatment-for-bronchial-carcinoid-patient-selection-and-predictors-of-outcome
#4
Ellen M B P Reuling, Chris Dickhoff, Peter W Plaisier, Veerle M H Coupé, Albert H A Mazairac, Rutger J Lely, H Jaap Bonjer, Johannes M A Daniels
BACKGROUND: Traditionally, surgical resection is the preferred treatment for typical carcinoids and atypical carcinoids located in the lungs. Recently however, several studies have shown excellent long-term outcome after endobronchial treatment of carcinoid tumors located in the central airways. This study investigates clinical and radiological features as predictors of successful endobronchial treatment in patients with a bronchial carcinoid tumor. OBJECTIVES: To identify clinical and radiological features predictive of successful endobronchial treatment in patients with bronchial carcinoid...
February 12, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29432305/pediatric-bronchial-carcinoid-tumors-a-case-series-and-review-of-the-literature
#5
Samara L Potter, Josephine HaDuong, Fatih Okcu, Hao Wu, Murali Chintagumpala, Rajkumar Venkatramani
Bronchial carcinoid tumor, while rare, remains the most common primary malignant lung tumor in children. We present a retrospective analysis of 7 patients with typical bronchial carcinoid tumors diagnosed at 2 pediatric tertiary care referral centers between 1990 and 2014. The most common presenting symptom was pneumonia, followed by respiratory distress. Somatostatin scans were performed in selected patients. All patients had negative resection margin following surgery and were alive without disease at last follow-up...
February 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29424302/the-role-of-5-ht1a-receptor-in-the-cancer-as-a-new-opportunity-in-medicinal-chemistry
#6
Angela Corvino, Ferdinando Fiorino, Beatrice Severino, Irene Saccone, Francesco Frecentese, Elisa Perissutti, Paola Di Vaio, Vincenzo Santagada, Giuseppe Caliendo, Elisa Magli
The 5-HT1A receptor is a pharmacologically well characterized serotonin receptor subtype and it has long been investigated because of its involvement in several physio-pathological mechanisms and treatment of neurological diseases like ansia and depression. Serotonin (5-HT) also shows many non-neural functions such as essential hypertension, embryogenesis, follicle maturation and behavior. Moreover it exerts a growth factor function on different types of non-tumoral cells, and it was also found to be related to oncogenes...
February 9, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29422640/mutational-landscape-of-goblet-cell-carcinoids-and-adenocarcinoma-ex-goblet-cell-carcinoids-of-the-appendix-is-distinct-from-typical-carcinoids-and-colorectal-adenocarcinomas
#7
Melanie Johncilla, Matthew Stachler, Joseph Misdraji, Mikhail Lisovsky, Masato Yozu, Neal Lindeman, Gregory Y Lauwers, Robert D Odze, Amitabh Srivastava
There is limited data on the spectrum of molecular alterations in goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix. We used next generation sequencing to determine mutations of potential pathogenetic and therapeutic significance in this rare group of tumors. Adequate DNA was successfully extracted in 34/46 cases and the final group included 18 goblet cell carcinoids and 16 adenocarcinoma ex goblet cell carcinoids. Illumina TruSeq™ was used for sequencing exons of a custom 282 gene panel using an Illumina HiSeq 2000...
February 8, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29420361/primary-ovarian-carcinoid-extensive-clinical-experience-with-an-underrecognized-uncommon-entity
#8
Veronica A Preda, Marina Chitoni, Dennis Talbot, Nicholas Reed, Ashley B Grossman
PURPOSE: Primary ovarian neuroendocrine tumors (NETs) develop in pure form or in association with other tumors, mainly teratomas. The available data regarding this rare condition are limited. Much of the literature focuses on single case reports, previously dismissed as a totally benign disorder, and thus long-term considerations and evidence-based management guidelines are lacking. The objective of the current study was to describe the clinical and pathologic characteristics and the effect of various therapeutic modalities on patient morbidity and mortality from 2 major centers...
February 8, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29419954/-analysis-of-the-comorbidities-and-role-of-laparoscopy-in-recurrent-abdominal-pain
#9
V Alonso Arroyo, M Molina Mata, C Cadaval Gallardo, M J Moya Jiménez, R Granero Cendón, M Victoria Maestre, J Morcillo Azcárate
INTRODUCTION AND OBJECTIVES: Recurrent abdominal pain is defined as > 3 episodes of abdominal pain accompanied by affectation of the daily activity, during > 3 months. Our objective is to analyze the role of diagnostic and/or therapeutic laparoscopy. MATERIAL AND METHODS: A descriptive, retrospective study from 2004 to 2016. Patients: <14 years with DAR who underwent laparoscopy. Variables: age, sex, history, surgical findings, histology and follow-up. RESULTS: 55 patients...
February 1, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29414399/goblet-cell-carcinoid-of-the-appendix-an-interobserver-variability-study-using-two-proposed-classification-systems
#10
Chelsea Maedler, Thomas Arnason, Alastair Dorreen, Heidi Sapp, Mathieu Castonguay, Joanne Murphy, Sorin Selegean, Weei-Yuarn Huang
Goblet cell carcinoid (GCC) is an uncommon tumor of the vermiform appendix. Due to a broad spectrum of morphological differentiation, subclassification and grading of GCCs remains an area of controversy. Two separate systems have proposed classifying GCC tumors into three (classical GCC; adenocarcinoma ex-GCC, signet ring cell type; adenocarcinoma ex-GCC, poorly differentiated carcinoma type) OR two subgroups (low and high grade GCC) based on morphological criteria. We independently compared the inter-observer variability associated with each classification system...
February 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29402880/adenocarcinoma-in-a-blind-loop-of-the-ileum-53-years-after-an-ileotransversostomy-procedure
#11
Ryohei Takei, Ichiro Onishi, Ryosuke Zaimoku, Naoki Makita, Yasumichi Yagi, Masato Kayahara
BACKGROUND Primary small bowel cancer is a rare malignancy; the common histopathological types are carcinoid and adenocarcinoma. Inflammatory bowel diseases and familial adenomatous polyposis are known risk factors for small bowel cancer. Additionally, cases of surgery-induced small bowel adenocarcinoma are sometimes reported after ileostomy. CASE REPORT A 84-year-old woman, who had undergone ileotransversostomy for intestinal obstruction due to postoperative adhesion following appendectomy at the age of 31 years, was referred to our hospital for further examination after experiencing abdominal pain in the right lower quadrant for 2 weeks...
February 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29395828/4-valve-heart-disease-and-right-heart-failure
#12
McKenzie Hollon, Kathyrn Glas, Michele Sumler
Carcinoid heart disease is a rare form of heart disease due to secretion of vasoactive compounds, including serotonin, from gastrointestinal tumors. This E-challenge examines the case of a patient with advanced carcinoid heart disease who presented to the operating room (OR) for a tricuspid valve replacement. Once the patient was in the OR, intraoperative transesophageal echocardiography was used to discover a patent foramen ovale and involvement of all 4 valves with regurgitant lesions. The patient underwent tricuspid valve replacement, pulmonic valve replacement, right ventricular outflow tract reconstruction, and patent foramen closure in the OR and experienced subsequent fulminant right heart failure...
October 13, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29392469/endoscopic-and-surgical-management-of-nonampullary-duodenal-neoplasms
#13
Michael J Bartel, Ruchir Puri, Bhaumik Brahmbhatt, Wei-Chung Chen, Daniel Kim, Roberto C Simons Linares, John A Stauffer, Mauricia A Buchanan, Steven P Bowers, Timothy A Woodward, Michael B Wallace, Massimo Raimondo, Horacio J Asbun
BACKGROUND: Sporadic nonampullary duodenal neoplasms (SNADN) can have malignant potential for which endoscopic and surgical resections are offered. We report combined gastroenterologic and surgical experience for treatment of SNADN, including endoscopic mucosal resection (EMR) and pancreas-preserving partial duodenectomy (PPPD). METHODS: We retrospectively reviewed 121 consecutive patients, who underwent 30 PPPDs and 91 EMRs for mucosal and submucosal SNADN. Decision to undergo EMR or surgical resection was based on expert endoscopist and surgeon discretion including multidisciplinary tumor board review...
February 1, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29386066/carcinoid-heart-disease-revealed-by-cyanosis-with-both-right-and-left-valvular-involvement-a-case-report
#14
Khadija Khay, Salim Arous, Tarik Bentaoune, Abdenasser Drighil, Rachida Habbal
BACKGROUND: Carcinoid heart disease is a frequent complication of carcinoid syndrome. It is related to the release by the carcinoid tumor and/or its metastases of bioactive substances such as serotonin. It is characterized by right-sided valvular involvement and can lead to right-sided heart failure. It is a prognostic factor of carcinoid syndrome. CASE PRESENTATION: We report the case of a 53-year-old African woman with an endocrine tumor of her small intestine complicated by carcinoid heart disease, revealed by right-sided heart failure...
January 31, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29384931/superior-mediastinal-typical-carcinoid-detected-by-99mtc-mibi-spect-ct-imaging-a-case-report
#15
Chenghui Lu, Zenghua Wang, Guoqiang Wang, Xufu Wang, Xinfeng Liu
RATIONALE: This is a rare case of mediastinal typical carcinoid tumor with elevated parathyroid hormone (PTH) and hypercalcemia detected by Tc -methoxy-isobutyl-isonitrile(Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) imaging. PATIENT CONCERNS: A 65-year-old male patient presented with hypercalcemia and elevated PTH. DIAGNOSES: The preoperative diagnosis was ectopic parathyroid adenoma in the right superior mediastinum...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381978/cholecystectomy-with-gallbladder-bed-cautery-might-be-sufficient-for-t1bn0m0-neuroendocrine-carcinoma-of-gallbladders-cases-report-and-literature-review
#16
Wei Liu, Weijie Chen, Xiaodong He, Qiang Qu, Tao Hong, Binglu Li
INTRODUCTION: Neuroendocrine carcinoma was a rare kind tumor in gallbladders. So far, there is no consensus of treatment of the gallbladder neuroendocrine carcinoma. CASE PRESENTATION: Three patients, 1 male and 2 females, were admitted in our hospital because of right upper quadrant pain. No one complained fever, jaundice, weight loss, or carcinoid syndrome-related symptoms such as diarrhea, flushing, edema, and wheezing. The MRI detected the broad base of gallbladder tumors...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377286/diagnostic-approach-to-subcutaneous-nodules-in-patients-with-neuroendocrine-tumors-treated-with-depot-somatostatin-analogs-a-cross-sectional-study
#17
Pablo Chicharro, Amalia Paniagua, Pedro Rodríguez-Jiménez, Sara Ibañes, Begoña Cortina, Javier Ribeiro, Miguel Ángel Sampedro-Núñez, Javier Fraga, Mónica Marazuela, Esteban Daudén
BACKGROUND: The presence of cutaneous nodules in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) receiving depot somatostatin analogs (SSAs) is a diagnostic challenge as differential diagnosis between injection site reactions and metastases is essential. OBJECTIVE: To characterize the clinical, radiological, cytological and histopathological features of subcutaneous nodules in patients with GEP-NETs treated with SSAs. MATERIALS AND METHODS: Retrospective, cross-sectional study of patients with GEP-NETs treated with SSAs in whom subcutaneous nodules were detected on routine abdominal CT scans...
January 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29361823/trends-in-gastric-cancer-incidence-according-to-the-clinicopathological-characteristics-in-korea-1999-2014
#18
Bang Wool Eom, Kyu-Won Jung, Young-Joo Won, Hannah Yang, Young-Woo Kim
Purpose: The aim of this study was to evaluate recent trends in gastric cancer incidence according to the age, sex, and tumor location in the Korean population. Materials and Methods: Using data from the Korea Central Cancer Registry between 1999 and 2014, gastric cancer incidence, annual percent changes (APCs), and male-to-female incidence rate ratios (IRRs) according to tumor location were determined. The distribution of disease extent according to the tumor location and its changes between 2006 and 2014 were also analyzed...
January 15, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29360191/insulinoma-associated-protein-1-is-a-sensitive-and-specific-marker-of-neuroendocrine-lung-neoplasms-in-cytology-specimens
#19
Erika E Doxtader, Sanjay Mukhopadhyay
BACKGROUND: Recent studies suggest that insulinoma-associated protein 1 (INSM1) is a sensitive and specific marker of neuroendocrine neoplasms. The aims of this study were to determine whether INSM1 can be reliably used in cytology (Cellient) cell blocks, to ascertain whether staining correlates with paired surgical pathology specimens, and to compare its sensitivity and specificity with those of synaptophysin (SYN), chromogranin (CHR), and CD56 for neuroendocrine lung tumors. METHODS: Seventy-four primary lung neoplasms diagnosed on cytology were stained with INSM1, SYN, CHR, and CD56: 41 small cell lung carcinomas (SCLCs), 1 large cell neuroendocrine carcinoma (LCNEC), 10 carcinoid tumors, 11 adenocarcinomas, 9 squamous cell carcinomas, 1 mesothelioma and 1 poorly differentiated non-small cell lung carcinoma, not otherwise specified...
January 23, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29354173/pulmonary-carcinoids-analysis-of-early-and-long-term-surgical-treatment-outcomes-in-a-group-of-90-patients
#20
Mariusz Kasprzyk, Jan Musiałkiewicz, Mikołaj Kolasiński, Kajetan Jagiełka, Wojciech Dyszkiewicz
Introduction: Over the years, pulmonary carcinoids have been treated as locally malignant tumors because of the favorable prognosis. It is currently known that the clinical course of the disease is mainly dependent on the carcinoid subtype. Aim: To analyze the early and long-term surgical treatment outcomes for typical and atypical carcinoids. Material and methods: A total of 90 patients were treated surgically for pulmonary carcinoid tumors in the years 2007-2015...
December 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
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