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Carcinoid tumor

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https://www.readbyqxmd.com/read/29221341/atypical-carcinoid-localized-at-the-bronchus-accompanied-by-diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-in-the-distal-lung-a-rare-case-report
#1
Kyoshiro Takegahara, Akira Sato, Takayuki Ibi, Tatsuya Inoue, Jitsuo Usuda
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is hyperplasia of noninvasive neuroendocrine cells originating from Kultchitsky cells. This is a rare pathological condition, suspected to be a precursor lesion of carcinoid, together with tumorlet. In the WHO histological classification (4th edition) revised in 2015, DIPNECH was added to the category that includes neuroendocrine tumors. Our patient was a 77-year-old woman who initially visited another doctor because of coughing. Chest CT revealed a mass occluding the right intermediate bronchial trunk, and bronchial carcinoid was suspected from biopsy findings, leading to referral of this patient to our department...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221311/uniportal-video-assisted-thoracic-surgery-lobectomy-in-a-patient-with-carcinoid-tumor-located-at-the-orifice-of-the-right-lower-lobe
#2
Semih Halezeroğlu
We present here a 47-year old male patient who had a typical carcinoid tumor located at the orifice of right lower lobe bronchus underwent uniportal thoracoscopic lower lobectomy following bronchoscopic removal of the endobronchial tumor. Tumor was seen by bronchoscopy to protrude out from the lower lobe into the intermediary bronchus obstructing the lower lobe completely and the middle lob partially. However, the origin of the endobronchial tumor was in the distal part of the lower lobe bronchus. In this case, open surgery could be an alternative to save the middle lobe by incising the lower lobe bronchus to pull out the endobronchial tumor first during thoracotomy...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29215535/the-clinicopathological-aspects-of-primary-presacral-neuroendocrine-neoplasms-one-center-experience
#3
Guoqing Yang, Deepti Dhall, Run Yu, Richard Tuli, Farin F Amersi, Marc L Friedman, Nicholas N Nissen, Andrew E Hendifar
OBJECTIVES: Presacral neuroendocrine neoplasms (NENs) are rare entities that are found at the presacral space. We report our experience in the diagnosis, management, and outcomes of primary presacral NENs. METHODS: This was an institutional review board-approved retrospective review of medical records and surgical pathology specimens of patients with a diagnosis of NENs at Cedars-Sinai Medical Center between January 2000 and April 2016. RESULTS: Ten patients were identified...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29202350/case-report-ectopic-cushing-s-syndrome-in-a-young-male-with-hidden-lung-carcinoid-tumor
#4
Ghanem Aljassem, Hazem Aljasem
INTRODUCTION: Ectopic Cushing syndrome is a form of Cushing's in which a tumor outside the pituitary gland produces adrenocorticotropic hormone (ACTH). Small cell carcinoma and carcinoid of the lung comprises half of its cases. The main purpose of this study is to present a case of ectopic Cushing syndrome caused by a hidden lung carcinoid and how to manage it. PRESENTATION OF CASE: Here we present a case of a 26year old young male complains of increased weight and appetite, proximal muscle weakness, easy bruising and appearing of purple striae on his abdomen, with a final diagnosis of ACTH secreting lung carcinoid...
November 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29201454/the-role-of-peptide-receptor-radionuclide-therapy-in-advanced-metastatic-thoracic-neuroendocrine-tumors
#5
REVIEW
Lisa Bodei, Jarosław B Ćwikla, Mark Kidd, Irvin M Modlin
Bronchopulmonary (BP) neuroendocrine tumors (NETs) comprise a spectrum of tumors that develop from respiratory neuroendocrine cells and represent ~20% of all lung neoplasia and ~30% of all NETs. The only curative treatment is surgical resection. For well-differentiated forms (typical and atypical carcinoids), medical therapy ranges from bioactive agents (e.g., somatostatin analogs), to biotherapy (e.g., everolimus), standard chemotherapy and peptide receptor radionuclide therapy (PRRT). PRRT with radiolabeled somatostatin analogs is an innovative treatment for inoperable or metastasized, well/moderately differentiated, NET...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29201453/the-role-of-multimodal-treatment-in-patients-with-advanced-lung-neuroendocrine-tumors
#6
REVIEW
Nicola Fazio, Antonio Ungaro, Francesca Spada, Chiara Alessandra Cella, Eleonora Pisa, Massimo Barberis, Chiara Grana, Dario Zerini, Emilio Bertani, Dario Ribero, Luigi Funicelli, Guido Bonomo, Davide Ravizza, Juliana Guarize, Filippo De Marinis, Francesco Petrella, Ester Del Signore, Giuseppe Pelosi, Lorenzo Spaggiari
Lung neuroendocrine tumors (NETs) comprise typical (TC) and atypical carcinoids (AC). They represent the well differentiated (WD) or low/intermediate grade forms of lung neuroendocrine neoplasms (NENs). Unlike the lung poorly differentiated NENs, that are usually treated with chemotherapy, lung NETs can be managed with several different therapies, making a multidisciplinary interaction a key point. We critically discussed the multimodal clinical management of patients with advanced lung NETs. Provided that no therapeutic algorithm has been validate so far, each clinical case should be discussed within a NEN-dedicated multidisciplinary team...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29201449/molecular-strategies-in-the-management-of-bronchopulmonary-and-thymic-neuroendocrine-neoplasms
#7
REVIEW
Irvin M Modlin, Mark Kidd, Pier-Luigi Filosso, Matteo Roffinella, Anna Lewczuk, Jaroslaw Cwikla, Lisa Bodei, Agnieska Kolasinska-Cwikla, Kyung-Min Chung, Margot E Tesselaar, Ignat A Drozdov
Thoracic NETs [bronchopulmonary NETs (BPNETs) and thymic NETs (TNET)] share a common anatomic primary location, likely a common cell of origin, the "Kulchitsky cell" and presumably, a common etiopathogenesis. Although they are similarly grouped into well-differentiated [typical carcinoids (TC) and atypical carcinoids (AC)] and poorly differentiated neoplasms and both express somatostatin receptors, they exhibit a wide variation in clinical behavior. TNETs are more aggressive, are frequently metastatic, and have a lower 5-year survival rate (~50% vs...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29201448/neuroendocrine-tumors-of-the-thymus-and-mediastinum
#8
REVIEW
Hanibal Bohnenberger, Helen Dinter, Alexander König, Philipp Ströbel
Neuroendocrine tumors of the thymus (tNET) and mediastinum are very rare neoplasms with scarce available data. All subtypes [typical and atypical carcinoid tumors (TC and AC), large cell neuroendocrine and small cell carcinoma (SCC)] observed elsewhere in the body occur also in the mediastinum and show only few if any organ-specific morphological differences. Although all available data suggest that the broad principles that govern the biology (and hence) the classification of these tumors in general apply also to tNET, there are a few noteworthy peculiarities related e...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29201447/lung-neuroendocrine-tumors-pathological-characteristics
#9
REVIEW
Luisella Righi, Gaia Gatti, Marco Volante, Mauro Papotti
Lung neuroendocrine tumors (NETs) are a heterogeneous family of neoplasms comprising four histologic types, namely typical and atypical carcinoid (TC and AC), large-cell neuroendocrine and small cell carcinoma (SCC). Classification criteria include the number of mitoses per 2 mm2, the occurrence and extent of necrosis, cytological and histological features and immunohistochemistry for neuroendocrine markers. The classification system and the diagnostic workflow of lung NETs are apparently easy to apply and well established...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29194700/metastatic-laryngeal-large-cell-neuroendocrine-carcinoma-a-rare-case-of-presentation-and-extreme-tumor-burden
#10
Andrew Dunn, Brannon G Broadfoot, Jennifer Hunt, Jennifer R Kaley, Omar Atiq, Narendra Babu Gutta, Xiaofei Wang, Jerad M Gardner, Sara C Shalin
Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical carcinoid tumors were considered synonymous; however, laryngeal LCNEC has been shown to have higher mitotic rates and worse prognosis, which has led to laryngeal LCNEC to be separated from atypical carcinoid and classified as a poorly differentiated neuroendocrine carcinoma in the most recent World Health Organization classification...
December 1, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29194046/updates-on-the-biology-of-serotonin-and-tryptophan-hydroxylase
#11
Tara Swami, H Christian Weber
PURPOSE OF REVIEW: To summarize the most recent findings relevant to the biology of serotonin (5-hydroxytryptamine; 5-HT) and the enzyme tryptophan hydroxylase (TPH) in human gastrointestinal disease. RECENT FINDINGS: Serotonin is synthesized in the central nervous system (CNS) and the gastrointestinal tract where it is secreted from enteroendocrine cells. Its biosynthesis is regulated by two isoforms of the enzyme TPH of which TPH1 is localized predominantly in gastrointestinal enteroendocrine cells...
November 30, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29192809/kidney-carcinoid-tumor-histological-immunohistochemical-and-ultrastructural-features
#12
Xin Gu, Minyu Cheng, Guillermo A Herrera
Primary carcinoid tumor of the kidney is uncommon. Only limited morphologic studies have been reported in the literature. In general, renal carcinoid tumor reveals typical morphological features as present in carcinoid tumors in the other organs, i.e. growing as trabeculae intermixed with nests of monotonous cuboidal cells that show "salt and pepper" nuclear appearance. As reported in other organs, different morphological expressions may also present in renal carcinoid tumors, such as papillary, pseudoglandular or solid growth patterns and clear/eosinophilic cytoplasmic changes...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29188355/-resection-concepts-for-early-stage-neuroendocrine-tumors-of-the-lungs-and-bronchi
#13
REVIEW
T Ploenes, C Aigner
BACKGROUND: Neuroendocrine tumors of the lungs are a very inhomogeneous group of malignancies. The surgical treatment should be adapted to the anatomical localization and histological subtype and individualized according to the functional reserve. MATERIAL AND METHODS: We performed a selective review of current literature, which was supplemented by personal experiences. RESULTS: The currently available outcome data are very inhomogeneous and depend on the histological subtype of neuroendocrine pulmonary tumors...
November 29, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29184871/peptide-yy-producing-strumal-carcinoid-tumor-of-the-ovary-in-a-postmenopausal-woman-a-rare-cause-of-chronic-constipation
#14
Hye Kyung Noh, Byung Su Kwon, Yoon Hwa Kim, Nam Kyung Lee, Kyung Un Choi, Dong Soo Suh, Dong Hyung Lee, Ki Hyung Kim
Strumal carcinoid tumor of the ovary is a rare subtype of ovarian carcinoid tumors; it is characterized by an intimate mixture of thyroid and carcinoid tissues. We present a case of a 64-year-old woman who presented with the chief complaint of persistent, severe constipation for over 5 years; she was later found to have an ovarian strumal carcinoid tumor. Computed tomography showed a well-defined solid mass measuring 6.4 cm at the right adnexa. The patient underwent right salpingo-oophorectomy and was histopathologically diagnosed as having a strumal carcinoid tumor...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29177160/neuroendocrine-neoplasms-dichotomy-origin-and-classifications
#15
REVIEW
Günter Klöppel
Neuroendocrine neoplasms (NENs) are heterogeneous tumors with a common phenotype. There are two fundamentally different groups of NENs: well-differentiated, low-proliferating NENs, called neuroendocrine tumors (NETs) or carcinoids, and poorly differentiated, highly proliferating NENs, called small- or large-cell neuroendocrine carcinomas (NECs). This NEN dichotomy is probably due to an origin from different neuroendocrine progenitor cells. The current World Health Organization (WHO) classification of gastrointestinal NENs uses the Ki67 proliferation index to grade NETs as G1 or G2, and NECs as G3...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29176078/one-stage-surgery-for-synchronous-liver-metastasis-from-a-neuroendocrine-tumor-of-the-colon-a-case-report
#16
Nicola Tartaglia, Alessandra Di Lascia, Pasquale Cianci, Alberto Fersini, Francesca Sanguedolce, Roberta Iadarola, Sabino Capuzzolo, Vincenzo Neri, Antonio Ambrosi
INTRODUCTION: Neuroendocrine tumors (NETs) are a heterogeneous group of tumors. NET of colon represent less than 1% of colonic tumors. Synchronous liver metastases, present in 75-80%, are considered significant adverse prognostic indicators. Liver is the second commonest site for metastasis in patients with colorectal neuroendocrine tumors. Available treatment options include surgical resection, chemotherapy, biotherapy. Surgery is the gold standard for curative therapy and it is strictly related to the localization, the grade of tumor, and the stage of disease...
November 20, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29173655/management-of-well-differentiated-gastroenteropancreatic-neuroendocrine-tumors-gepnets-a-review
#17
REVIEW
Gurleen Pasricha, Parikshit Padhi, Nour Daboul, Dulabh K Monga
PURPOSE: Neuroendocrine tumors (NETs) are heterogeneous tumors that arise from the neuroendocrine cells of the digestive tract and other organs, such as the lung, ovary, and thyroid glands. They can be well differentiated or poorly differentiated, and management of these tumors differs for each histologic subtype. We have performed a review of NETs and focused on management of well-differentiated gastroenteropancreatic neuroendocrine tumors (GEPNETs) and carcinoid syndrome. METHODS: A PubMed search was performed to obtain articles on the management of well-differentiated NETs...
November 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29142475/predictive-factors-associated-with-carcinoid-syndrome-in-patients-with-gastrointestinal-neuroendocrine-tumors
#18
Beilei Cai, Michael S Broder, Eunice Chang, Tingjian Yan, David C Metz
AIM: To discover unknown factors associated with carcinoid syndrome (CS) with the goal of earlier diagnosis of CS. METHODS: In this retrospective case-control study using United States administrative claims, patients (≥ 18 years) newly-diagnosed with gastrointestinal neuroendocrine tumors (GI NETs) without CS (controls) were exactly matched to patients with CS (cases) based on NET diagnosis date at a 3-to-1 ratio. Study index date was first CS diagnosis (controls: same distance from NET diagnosis as cases)...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29138755/paraneoplastic-hepatopathy-associated-with-gastrointestinal-carcinoid
#19
Dhruv Mehta, Priyanka Chugh, Lavneet Chawla, Daniela Jodorkovsky
Paraneoplastic hepatopathy has been reported with various malignancies, most commonly with renal cell cancer. This non-metastatic hepatic dysfunction in such malignancies is known as Stauffer syndrome. We describe a 61-year-old man who presented with symptoms of bowel obstruction with marked cholestasis and high levels of alkaline phosphatase and bilirubin. Imaging revealed an unremarkable liver and a mass in the ileocecal valve with mesenteric lymphadenopathy. Biopsies were consistent with a carcinoid tumor...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29132704/extent-of-resection-and-lymph-node-assessment-for-clinical-stage-t1an0m0-typical-carcinoid-tumors
#20
Lisa M Brown, David T Cooke, James R Jett, Elizabeth A David
BACKGROUND: The optimal extent of lung resection and lymph node (LN) assessment for surgical treatment of clinical stage T1aN0M0 typical carcinoid tumors is unclear. Using a cohort including only these patients, we aimed to determine the impact of extent of lung resection and LN assessment on overall survival. METHODS: Patients undergoing lobectomy or sublobar resection for clinical stage T1aN0M0 intraparenchymal typical carcinoid tumor were identified in the National Cancer Data Base from 1998 to 2012...
November 11, 2017: Annals of Thoracic Surgery
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