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https://www.readbyqxmd.com/read/29656783/nationwide-overview-of-survival-and-management-of-appendiceal-tumors-in-children
#1
Punam P Parikh, Eduardo A Perez, Holly L Neville, Anthony R Hogan, Juan E Sola
INTRODUCTION: There remains a paucity of literature on survival related to pediatric appendiceal tumors. The purpose of this study was to determine the incidence, surgical management, and survival outcomes of appendiceal tumors in pediatric patients. METHODS: The Surveillance, Epidemiology, and End Results (SEER) Registry was analyzed for pediatric appendiceal tumors from 1973 to 2011. Parameters analyzed were: tumor type, surgical management (appendectomy vs. extensive resection), tumor size, and lymph node sampling...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29650525/flushing-disorders-associated-with-gastrointestinal-symptoms-part-1-neuroendocrine-tumors-mast-cell-disorders-and-hyperbasophila
#2
REVIEW
Vaibhav Rastogi, Devina Singh, Joseph J Mazza, Dennis Yang, Dipendra Parajuli, Steven H Yale
Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands...
April 12, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29629318/role-of-surgery-in-pancreatic-neuroendocrine-tumor
#3
REVIEW
Kai Pun Wong, Julian Shun Tsang, Brian Hung-Hin Lang
Pancreatic neuroendocrine tumours (PNETs) are rare. They are generally accepted to be slow-growing and have an indolent course. These tumours can be non-functioning or functioning, consisting of a biochemically heterogeneous group of tumours including insulinomas, gastrinomas, carcinoids and glucagonomas. Although surgery remains the mainstay of treatment, controversy still exists especially for non-functioning tumours <2 cm in size. Whether these should be resected or undergo intensive surveillance remains unclear...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29629316/management-of-functional-neuroendocrine-tumors-of-the-pancreas
#4
REVIEW
Kjell Öberg
Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Recent whole genome sequencing of pNETs has demonstrated mutations in the DNA repair genes MUTYH and point mutations and gene fusions in four main pathways from chromatin remodeling, DNA damage repair, activation of mechanistic target of rapamycin (mTOR) signaling and the telomere maintenance...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29626975/a-77-year-old-woman-with-acute-shortness-of-breath-and-chest-pain
#5
Ryan Hyde, Julian Chung, Jason Chertoff, Hassan Alnuaimat, Ali Ataya
A 77-year-old woman presented to the hospital with symptoms of progressive shortness of breath with associated right-sided pleuritic pain. The patient had begun noting dyspnea on exertion, limiting her ability to go on hikes over the few days prior to admission. Her medical history is significant for carcinoid tumor status postresection in 2012 without recurrence. She has no history of thromboembolism or clotting disorders, and she has no history of smoking or drug abuse. Current medications include amlodipine, celecoxib, hydrochlorothiazide, and rosuvastatin...
April 2018: Chest
https://www.readbyqxmd.com/read/29622373/antidepressants-appear-safe-in-patients-with-carcinoid-tumor-results-of-a-restrospective-review
#6
Elie Isenberg-Grzeda, Meredith MacGregor, Afton Bergel, Stacy Eagle, Fernando Espi-Forcen, Reema Mehta, Konstantina Matsoukas, Jonathan Wills, Diane Reidy-Lagunes, Yesne Alici
INTRODUCTION: Patients living with neuroendocrine tumors have high rates of depression, often necessitating antidepressants, including selective serotonin reuptake inhibitors (SSRI). Neuroendocrine tumors (NETs) secrete vasoactive substances, including serotonin, which contribute to the cluster of symptoms known as carcinoid syndrome (flushing and diarrhea). Controversy exists over whether or not antidepressants are safe in NET. We aimed to study the safety of antidepressant use in NET patients...
March 21, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29620585/ovarian-sertoli-leydig-cell-tumor-with-heterologous-hepatocytes-and-a-hepatocellular-carcinomatous-element
#7
Sohei Yamamoto, Yu Sakai
Sertoli-Leydig cell tumors are a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and sometimes heterologous elements. We describe the case of a 68-yr-old woman who presented with abdominal distention. A computed tomographic scan revealed a large right adnexal mass without evidence of intrahepatic tumors, and a complete cytoreductive surgery was performed. Pathologic examination revealed a moderately differentiated Sertoli-Leydig cell tumor with various heterologous elements, including gastrointestinal-type glands, insular carcinoid, and aggregations of hepatocytes without significant cytologic atypia...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29619591/a-case-of-anastomotic-stenosis-of-the-small-intestine-caused-by-cholesterol-crystal-embolism
#8
Koji Murono, Kazushige Kawai, Keisuke Hata, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Takeshi Nishikawa, Kensuke Otani, Toshiaki Tanaka, Masako Ikemura, Hiroaki Nozawa
BACKGROUND: Cholesterol crystal embolism (CCE) is caused by small crystals of cholesterol dispersed from atherosclerotic plaques of the aorta. There is an increasing interest in CCE because of the increased use of endovascular treatments. Here, we report a rare case of intestinal stenosis caused by CCE after functional end-to-end anastomosis (FEEA). To our knowledge, this is the first report of CCE causing such an anastomotic stenosis. CASE PRESENTATION: A 77-year-old male patient underwent laparoscopy-assisted low anterior resection and protective ileostomy for rectal carcinoid tumor...
April 4, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29607953/a-rare-case-of-ampullary-goblet-cell-carcinoid
#9
Hitoshi Shibuya, Susumu Hijioka, Nobumasa Mizuno, Takamichi Kuwahara, Nozomi Okuno, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Sachiyo Oonishi, Yoshiko Murakami, Yasushi Yatabe, Masahiro Tajika, Yasumasa Niwa, Kazuo Hara
An asymptomatic 70-year-old woman was referred to our hospital because of liver enzyme elevation. Enhanced abdominal computed tomography demonstrated a small, round-shaped tumor with dilation of the common bile duct (CBD) and main pancreatic duct (MPD). A biopsy specimen from the papilla showed mucin-containing cells that were positive for endocrine markers on immunohistochemical staining. Endoscopic snare resection was done, and there was a positive vertical margin on pathology. Pancreaticoduodenectomy was then performed later...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29607688/posterior-fossa-metastasis-of-lung-carcinoid-tumor-case-report
#10
Rui Reinas, Raul B Santos, Djamel Kitumba, Antónia Furtado, Óscar L Alves, Mário Resende
Carcinoid tumors are generally indolent neoplasms. Brain metastases are rare and when present, yield a poor prognosis. We present the case of a 76-year old female surgically treated for an atypical bronchial carcinoid, staged as T2aN0M0G2. Without further adjuvant treatment she remained stable for four years, when she presented with headaches and gait imbalance. Brain MRI revealed a midline, intra-axial infratentorial lesion that was completely removal, of which histolology confirmed a carcinoid metastasis...
April 2, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29607201/clinical-implication-of-men1-mutation-in-surgically-resected-thymic-carcinoid-patients
#11
Xiongfei Li, Mingbiao Li, Tao Shi, Renwang Liu, Dian Ren, Fan Yang, Sen Wei, Gang Chen, Jun Chen, Song Xu
Thymic carcinoid is a rare but very aggressive neuroendocrine tumour derived from the neuroendocrine system. Here we report a male patient with thymic atypical carcinoid. Though thymic carcinoid is relatively common, the gene sequencing profile was performed and the gene sequencing result indicated germline multiple endocrine neoplasia type 1 (MEN1) mutation and two somatic mutations on MEN1 gene and no copy number variation or fusion events were detected. It is well-known that the mutation of MEN1 is the typical manifestation of MEN1 syndrome, which is an autosome dominant disease that includes varying combinations of more than 20 endocrine and non-endocrine tumors...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29600100/unusual-cardiac-paraganglioma-mimicking-an-atypical-carcinoid-tumor-of-the-lung
#12
Dean Spencer, Mark Evans, Beverly Wang, J Lawrence Delrosario, Timmy Cheng, Jeffrey Milliken
We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have a 4 cm × 3 cm mass abutting multiple cardiopulmonary structures. A biopsy was performed at an outside institution and pathology reported "atypical neuroendocrine carcinoma, consistent with carcinoid"...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29599626/benign-sebaceous-epithelioma-with-carcinoid-like-trabecular-cell-arrangement
#13
Shuji Suzuki, Kazunari Sugita, Tatsushi Shiomi, Osamu Yamamoto
A case of 75-year-old woman with sebaceous epithelioma was reported. The histological features were distinct in that it had a sinusoidal and carcinoid-like growth pattern, which has been reported in its malignant counterpart. Immunostaining for adipophilin was positive in the area with lipid-laden vacuolated cells, but the rest of tumor, which had cord-like nests, was negative. MIB index was 2%. CK5/6 and p40 were positive in the cord-like nesting areas. CK7, CK20, alpha SMA, and epithelial membrane antigen were negative in both the cord-like nesting areas and the adipose-like areas...
March 2018: Yonago Acta Medica
https://www.readbyqxmd.com/read/29581685/incidental-findings-in-routine-histopathological-examination-of-appendectomy-specimens-retrospective-analysis-of-1970-patients
#14
Oğuzhan Dincel, Mustafa Göksu, Bilge Aydın Türk, Burçin Pehlivanoğlu, Serap İşler
Diseases and tumors of the appendix vermiformis are very rare, except for acute appendicitis. This study aimed to examine rare findings in the histopathologic examinations of specimens of patients undergoing appendectomy due to the diagnosis of acute appendicitis. The files of 1970 patients undergoing appendectomy due to the diagnosis of acute appendicitis between March 2012 and March 2016 were retrospectively investigated. Rare findings were found in 59 (3 %) patients, and these were evaluated in detail. Patients' age, gender, pathology reports, and postoperation follow-ups were recorded...
February 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29579011/histologic-and-outcome-study-supports-reclassifying-appendiceal-goblet-cell-carcinoids-as-goblet-cell-adenocarcinomas-and-grading-and-staging-similarly-to-colonic-adenocarcinomas
#15
Masato Yozu, Melanie E Johncilla, Amitabh Srivastava, David P Ryan, James C Cusack, Leona Doyle, Namrata Setia, Michelle Yang, Gregory Y Lauwers, Robert D Odze, Joseph Misdraji
Goblet cell carcinoid tumors are amphicrine tumors whose biological behavior ranges from indolent to highly aggressive, depending on tumor grade. Current grading systems for these tumors are based on identifying an adenocarcinoma arising in the setting of a goblet cell carcinoid tumor, which distinguishes this tumor from other gastrointestinal tract adenocarcinomas. Because goblet cell tumors are predominantly tumors of mucin secreting cells, we propose that they be classified as goblet cell adenocarcinomas, and graded using a methodology that has parallels in colorectal adenocarcinoma grading...
March 23, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29561937/endobronchial-carcinoid-tumor-radiological-findings-of-a-clinical-case
#16
Rodolfo Mendes Queiroz, Danilo Brotto Ferreira de Santana, Rogério Nastri Filho, Gláucia Aparecida Magnani Landell, Paulo Roberto Félix, Marcus Vinícius Nascimento Valentin
We describe the case of a female patient, 21 years old, complaining of dyspnea attacks and wheezing 2 years ago. Chest radiography showed volume loss in the left lower lobe and ipsilateral retrocardiac triangular basal opacity. CT scan showed an extensive solid mass with apex protruding into the left main and lower lobar bronchi, causing distal atelectasis. Histopathological and immunohistochemical study of transbronchial biopsy of the lesion revealed a typical carcinoid tumor, confirmed after tumor resection with total left pneumectomy...
January 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29561272/novel-finding-of-paired-box-5-pax5-cytoplasmic-staining-in-well-differentiated-rectal-neuroendocrine-tumors-carcinoids-and-its-diagnostic-and-potentially-prognostic-utility
#17
Zhiyan Fu, Chunlai Zuo, Christine E Sheehan, Deepa T Patil, Jingmei Lin, Zhaohai Yang, Hwajeong Lee
Although nuclear immunostaining for paired box protein (PAX5) is widely used in practice, its cytoplasmic localization has not been evaluated. Recently we encountered cytoplasmic granular PAX5 staining in rectal well-differentiated neuroendocrine tumor (WD-NET) in the absence of nuclear staining. We investigated the specificity of this staining pattern for rectal NET (n=21) in comparison with 108 NETs, 1 WD rectal NET with elevated proliferation (WD-NET G3), and 40 poorly differentiated neuroendocrine carcinomas from the gastrointestinal and pancreatobiliary tract and liver...
March 20, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29558899/efficacy-and-safety-of-everolimus-treatment-in-a-hemodialysis-patient-with-metastatic-atypical-bronchial-carcinoid-case-report-and-literature-review
#18
M P Brizzi, A La Salvia, M Tampellini, C Sonetto, M Volante, G V Scagliotti
BACKGROUND: Everolimus was recently approved for the treatment of neuroendocrine tumors. However, its efficacy and tolerability in hemodialysis patients with end-stage renal disease is not established. CASE PRESENTATION: We describe the case of a 47-year-old man with end-stage renal disease who received everolimus plus Lanreotide for 9 months for the management of metastatic atypical bronchial carcinoid. CONCLUSIONS: Everolimus is a treatment option for hemodialysis patients with metastatic atypical bronchial carcinoid...
March 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29557536/neuroendocrine-carcinomas-of-the-larynx-and-head-and-neck-challenges-in-classification-and-grading
#19
Bayardo Perez-Ordoñez
Primary neuroendocrine carcinomas (NECs) of the larynx and head and neck are an uncommon and heterogeneous group of neoplasms categorized by the 2017 WHO Classification of Head and Neck Tumors as: (a) well-differentiated (WD-NEC), (b) moderately-differentiated (MD-NEC), and (c) poorly-differentiated (PD-NEC) with small cell and large cell types. The classification incorporates elements of differentiation and grading and closely correlates to the 5-year disease specific survival of 100, 52.8, 19.3 and 15.3% for each diagnostic category...
March 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29554055/reversible-nyctalopia-associated-with-vitamin-a-deficiency-after-resected-malignant-ileal-carcinoid-and-pancreatic-adenocarcinoma
#20
Bradley A Hansen, Carlos E Mendoza-Santiesteban, Thomas R Hedges
PURPOSE: To describe the rapid time course of visual and electroretinographic recovery from vitamin A deficiency in a patient with a history of multiple resected abdominal tumors, including ileal carcinoid and pancreatic adenocarcinoma. METHODS: A 61-year-old white man with a history of resected malignant ileal carcinoid and Stage III pancreatic adenocarcinoma referred with complaints of 6 weeks of difficulty with night vision. RESULTS: Initial testing showed significantly reduced scotopic rod responses in both eyes and decreased vitamin A levels and a normal cancer-associated retinopathy laboratory panel...
April 2018: Retinal Cases & Brief Reports
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