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https://www.readbyqxmd.com/read/28449405/the-impact-of-lesion-location-on-dysphagia-incidence-pattern-and-complications-in-acute-stroke-part-2-oropharyngeal-residue-swallow-and-cough-response-and-pneumonia
#1
S Suntrup-Krueger, A Kemmling, T Warnecke, C Hamacher, S Oelenberg, T Niederstadt, W Heindel, H Wiendl, R Dziewas
BACKGROUND AND PURPOSE: Dysphagia is a well-known complication of acute stroke. Given the complexity of cerebral swallowing control it is still difficult to predict which patients are likely to develop swallowing dysfunction based on their neuroimaging. In Part 2 of a comprehensive voxel-based imaging study, whether the location of a stroke lesion can be correlated with further dysfunctional swallowing patterns, pulmonary protective reflexes and pneumonia was evaluated. METHODS: In all, 200 acute stroke cases were investigated applying flexible endoscopic evaluation of swallowing within 96 h from admission...
April 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28449317/a-comparison-of-individual-based-genetic-distance-metrics-for-landscape-genetics
#2
A J Shirk, E L Landguth, S A Cushman
A major aim of landscape genetics is to understand how landscapes resist gene flow and thereby influence population genetic structure. An empirical understanding of this process provides a wealth of information that can be used to guide conservation and management of species in fragmented landscapes, and also to predict how landscape change may affect population viability. Statistical approaches to infer the true model among competing alternatives are based on the strength of the relationship between pairwise genetic distances and landscape distances among sampled individuals in a population...
April 27, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28449279/review-of-the-strengths-and-difficulties-questionnaire-translated-into-languages-spoken-by-children-and-adolescents-of-refugee-background
#3
Yvonne Stolk, Ida Kaplan, Josef Szwarc
The Strengths and Difficulties Questionnaire (SDQ), routinely used to screen for children's and adolescents' emotional and behavioural problems, has been translated into at least 80 languages. As children of refugee background are particularly vulnerable to mental health problems resulting from their refugee experiences, this review examines whether SDQs translated into languages spoken by major refugee groups are validated and culturally equivalent to the original SDQ and sensitive to change following interventions...
April 27, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28449114/neuro-symbolic-representation-learning-on-biological-knowledge-graphs
#4
Mona Alshahrani, Mohammed Asif Khan, Omar Maddouri, Akira R Kinjo, Núria Queralt-Rosinach, Robert Hoehndorf
Motivation: Biological data and knowledge bases increasingly rely on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. In the past years, feature learning methods that are applicable to graph-structured data are becoming available, but have not yet widely been applied and evaluated on structured biological knowledge. Results: We develop a novel method for feature learning on biological knowledge graphs...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28449074/fireprot-web-server-for-automated-design-of-thermostable-proteins
#5
Milos Musil, Jan Stourac, Jaroslav Bendl, Jan Brezovsky, Zbynek Prokop, Jaroslav Zendulka, Tomas Martinek, David Bednar, Jiri Damborsky
There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. A number of in silico tools for the prediction of the effect of mutations on protein stability have been developed recently. However, only single-point mutations with a small effect on protein stability are typically predicted with the existing tools and have to be followed by laborious protein expression, purification, and characterization. Here, we present FireProt, a web server for the automated design of multiple-point thermostable mutant proteins that combines structural and evolutionary information in its calculation core...
April 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28449031/rnablueprint-flexible-multiple-target-nucleic-acid-sequence-design
#6
Stefan Hammer, Birgit Tschiatschek, Christoph Flamm, Ivo L Hofacker, Sven Findeiß
Motivation: Realizing the value of synthetic biology in biotechnology and medicine requires the design of molecules with specialized functions. Due to its close structure to function relationship, and the availability of good structure prediction methods and energy models, RNA is perfectly suited to be synthetically engineered with predefined properties. However, currently available RNA design tools cannot be easily adapted to accommodate new design specifications. Furthermore, complicated sampling and optimization methods are often developed to suit a specific RNA design goal, adding to their inflexibility...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28448957/static-vs-dynamic-dft-prediction-of-ir-spectra-of-flexible-molecules-in-the-condensed-phase-the-clcf2cf-cf3-ocf2ch3-liquid-as-a-test-case
#7
REVIEW
Daria Ruth Galimberti, Alberto Milani, Marie-Pierre Gaigeot, Stefano Radice, Claudio Tonelli, Rosaldo Picozzi, Chiara Castiglioni
First-principles molecular dynamics (FPMD) simulations in the framework of Density Functional Theory (DFT) are carried out for the prediction of the infrared spectrum of the fluorinated molecule ClCF2CF(CF3)OCF2CH3 in liquid and gas phase. This molecule is characterized by a flexible structure, allowing the co-existence of several stable conformers, that differ by values of the torsional angles. FPMD computed spectra are compared to the experimental ones, and to Boltzmann weighted IR spectra based on gas phase calculations...
April 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28448955/ionization-spectroscopies-and-theoretical-calculations-of-cis-and-trans-3-fluoro-n-methylaniline-arn-n-1-2-van-der-waals-clusters-structures-and-binding-energies
#8
Lijuan Zhang, Dazhi Li, Min Cheng, Yikui Du, Qihe Zhu
The ab initio and dispersion-corrected density functional theory (DFT) calculations of the van der Waals (vdW) clusters of cis and trans 3-fluoro-N-methylaniline-Arn (3FNMA-Arn) (n=1,2) predict that, for cis and trans 3FNMA-Ar1 clusters, the π-bound geometry with the Ar atom sitting over the ring is the global minimum in both neutral and cationic states, while for cis and trans 3FNMA-Ar2 clusters, the [π|π]-bound sandwich structure with two Ar ligands occupying nearly equivalent π-bound positions above and below the ring plane is the global minimum...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28448953/electrostatic-frequency-maps-for-amide-i-mode-of-%C3%AE-peptide-comparison-of-molecular-mechanics-force-field-and-dft-calculations
#9
Kaicong Cai, Xuan Zheng, Fenfen Du
The spectroscopy of amide-I vibrations has been widely utilized for the understanding of dynamical structure of polypeptides. For the modeling of amide-I spectra, two frequency maps were built for β-peptide analogue (N-ethylpropionamide, NEPA) in a number of solvents within different schemes (molecular mechanics force field based, GM map; DFT calculation based, GD map), respectively. The electrostatic potentials on the amide unit that originated from solvents and peptide backbone were correlated to the amide-I frequency shift from gas phase to solution phase during map parameterization...
April 19, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28448925/geostatistics-as-a-tool-to-improve-the-natural-background-level-definition-an-application-in-groundwater
#10
Nico Dalla Libera, Paolo Fabbri, Leonardo Mason, Leonardo Piccinini, Marco Pola
The Natural Background Level (NBL), suggested by UE BRIDGE project, is suited for spatially distributed datasets providing a regional value that could be higher than the Threshold Value (TV) set by every country. In hydro-geochemically dis-homogeneous areas, the use of a unique regional NBL, higher than TV, could arise problems to distinguish between natural occurrences and anthropogenic contaminant sources. Hence, the goal of this study is to improve the NBL definition employing a geostatistical approach, which reconstructs the contaminant spatial structure accounting geochemical and hydrogeological relationships...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448834/cmc-prediction-for-ionic-surfactants-in-pure-water-and-aqueous-salt-solutions-based-solely-on-tabulated-molecular-parameters
#11
Stoyan I Karakashev, Stoyan K Smoukov
The critical micelle concentration (CMC) of various surfactants is difficult to predict accurately, yet often necessary to do in both industry and science. Hence, quantum-chemical software packages for precise calculation of CMC were developed, but they are expensive and time consuming. We show here an easy method for calculating CMC with a reasonable accuracy. Firstly, CMC0 (intrinsic CMC, absent added salt) was coupled with quantitative structure - property relationship (QSPR) with defined by us parameter "CMC predictor" f1...
April 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28448683/magnetic-resonance-imaging-connectivity-for-the-prediction-of-seizure-outcome-in-temporal-lobe-epilepsy
#12
Victoria L Morgan, Dario J Englot, Baxter P Rogers, Bennett A Landman, Ahmet Cakir, Bassel W Abou-Khalil, Adam W Anderson
OBJECTIVE: Currently, approximately 60-70% of patients with unilateral temporal lobe epilepsy (TLE) remain seizure-free 3 years after surgery. The goal of this work was to develop a presurgical connectivity-based biomarker to identify those patients who will have an unfavorable seizure outcome 1-year postsurgery. METHODS: Resting-state functional and diffusion-weighted 3T magnetic resonance imaging (MRI) was acquired from 22 unilateral (15 right, 7 left) patients with TLE and 35 healthy controls...
April 27, 2017: Epilepsia
https://www.readbyqxmd.com/read/28448529/a-genome-wide-analysis-of-the-rna-guided-silencing-pathway-in-coffee-reveals-insights-into-its-regulatory-mechanisms
#13
Christiane Noronha Fernandes-Brum, Pâmela Marinho Rezende, Thales Henrique Cherubino Ribeiro, Raphael Ricon de Oliveira, Thaís Cunha de Sousa Cardoso, Laurence Rodrigues do Amaral, Matheus de Souza Gomes, Antonio Chalfun-Junior
microRNAs (miRNAs) are derived from self-complementary hairpin structures, while small-interfering RNAs (siRNAs) are derived from double-stranded RNA (dsRNA) or hairpin precursors. The core mechanism of sRNA production involves DICER-like (DCL) in processing the smallRNAs (sRNAs) and ARGONAUTE (AGO) as effectors of silencing, and siRNA biogenesis also involves action of RNA-Dependent RNA Polymerase (RDR), Pol IV and Pol V in biogenesis. Several other proteins interact with the core proteins to guide sRNA biogenesis, action, and turnover...
2017: PloS One
https://www.readbyqxmd.com/read/28448499/when-do-correlations-increase-with-firing-rates-in-recurrent-networks
#14
Andrea K Barreiro, Cheng Ly
A central question in neuroscience is to understand how noisy firing patterns are used to transmit information. Because neural spiking is noisy, spiking patterns are often quantified via pairwise correlations, or the probability that two cells will spike coincidentally, above and beyond their baseline firing rate. One observation frequently made in experiments, is that correlations can increase systematically with firing rate. Theoretical studies have determined that stimulus-dependent correlations that increase with firing rate can have beneficial effects on information coding; however, we still have an incomplete understanding of what circuit mechanisms do, or do not, produce this correlation-firing rate relationship...
April 27, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28448253/a-map-of-abstract-relational-knowledge-in-the-human-hippocampal-entorhinal-cortex
#15
Mona M Garvert, Raymond J Dolan, Timothy Ej Behrens
The hippocampal-entorhinal system encodes a map of space that guides spatial navigation. Goal-directed behaviour outside of spatial navigation similarly requires a representation of abstract forms of relational knowledge. This information relies on the same neural system, but it is not known whether the organisational principles governing continuous maps may extend to the implicit encoding of discrete, non-spatial graphs. Here, we show that the human hippocampal-entorhinal system can represent relationships between objects using a metric that depends on associative strength...
April 27, 2017: ELife
https://www.readbyqxmd.com/read/28448148/tryptophan-to-arginine-substitution-in-puroindoline-b-alters-binding-to-model-eukaryotic-membrane
#16
Michael Richard Sanders, Luke Ashley Clifton, Richard Andrew Frazier, Rebecca Joanne Green
We have studied how puroindoline-b (PINB) mutants bind to model eukaryotic membranes dependent on binary composition of anionic:zwitterionic phospholipids, and the presence of cholesterol and sphingomyelin in the model membrane. We have found that the trends in lipid binding behavior are different for wild type PINB compared to its naturally occurring PINB(Trp44Arg) mutant form, and have seen evidence of protein-induced domain formation within the lipid layer structure. Results show that selective binding of antimicrobial peptides to different membrane types is as a result of differences in lipid composition and the arrangement of lipids within the membrane surface...
April 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28447822/social-cognition-internalized-stigma-and-recovery-orientation-among-adults-with-serious-mental-illness
#17
Katherine C Cunningham, Alicia Lucksted
OBJECTIVE: The social-cognitive model is useful in understanding internalized stigma, but research has not examined it in relationship to recovery orientation, an important outcome. This study examined the impact of the four stages of internalized stigma on recovery orientation and assessed cognitive insight as a moderator. METHOD: Data from a community sample of adults with serious mental illness (N = 268) were collected through structured interviews. Regression-based analyses were used to examine the main effects of internalized stigma on recovery orientation and the moderating effect of cognitive insight...
April 27, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28447708/protein-collapse-is-encoded-in-the-folded-state-architecture
#18
Himadri S Samanta, Pavel I Zhuravlev, Michael Hinczewski, Naoto Hori, Shaon Chakrabarti, D Thirumalai
Folded states of single domain globular proteins are compact with high packing density. The radius of gyration, Rg, of both the folded and unfolded states increase as N(ν) where N is the number of amino acids in the protein. The values of the Flory exponent ν are, respectively, ≈⅓ and ≈0.6 in the folded and unfolded states, coinciding with those for homopolymers. However, the extent of compaction of the unfolded state of a protein under low denaturant concentration (collapsibility), conditions favoring the formation of the folded state, is unknown...
April 27, 2017: Soft Matter
https://www.readbyqxmd.com/read/28447623/five-low-energy-phosphorene-allotropes-constructed-through-gene-segments-recombination
#19
Chaoyu He, ChunXiao Zhang, Chao Tang, Tao Ouyang, Jin Li, Jianxin Zhong
Based on the crystal structures of the previously proposed low energy η-P and θ-P, five new phosphorene allotropes were predicted through gene segments recombination method. These five new phosphorene allotropes are confirmed dynamically stable and energetically more favorable than their parents (η-P and θ-P). Especially, the XX-XX type G1-P is confirmed energetically more favorable than most of all the previously proposed phosphorene allotropes, including black phosphorene and blue phosphorene, which is highly expected to be synthesized in future experiment through vapor deposition or epitaxial growth method like blue β-P...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28447398/a-suite-of-essential-biodiversity-variables-for-detecting-critical-biodiversity-change
#20
Dirk S Schmeller, Lauren V Weatherdon, Adeline Loyau, Alberte Bondeau, Lluis Brotons, Neil Brummitt, Ilse R Geijzendorffer, Peter Haase, Mathias Kuemmerlen, Corinne S Martin, Jean-Baptiste Mihoub, Duccio Rocchini, Hannu Saarenmaa, Stefan Stoll, Eugenie C Regan
Key global indicators of biodiversity decline, such as the IUCN Red List Index and the Living Planet Index, have relatively long assessment intervals. This means they, due to their inherent structure, function as late-warning indicators that are retrospective, rather than prospective. These indicators are unquestionably important in providing information for biodiversity conservation, but the detection of early-warning signs of critical biodiversity change is also needed so that proactive management responses can be enacted promptly where required...
April 26, 2017: Biological Reviews of the Cambridge Philosophical Society
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