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Anorexia nervosa

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https://www.readbyqxmd.com/read/29684457/%C3%A2-%C2%BA4-gaba-a-receptors-of-hippocampal-pyramidal-neurons-are-associated-with-resilience-against-activity-based-anorexia-for-adolescent-female-mice-but-not-for-males
#1
Yi-Wen Chen, Hannah Actor-Engel, Chiye Aoki
Activity-based anorexia (ABA) is an animal model of anorexia nervosa, a mental illness with highest mortality and with onset that is most frequently during adolescence. We questioned whether vulnerability of adolescent mice to ABA differs between sexes and whether individual differences in resilience are causally linked to alpha4betadelta-GABAA R expression. C57BL6/J WT and α4-KO adolescent male and female mice underwent ABA induction by combining wheel access with food restriction. ABA vulnerability was measured as the extent of food restriction-evoked hyperactivity on a running wheel and body weight losses...
April 20, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29683775/-they-don-t-really-get-heard-a-qualitative-study-of-sibling-involvement-across-two-forms-of-family-based-treatment-for-adolescent-anorexia-nervosa
#2
Tanja van Langenberg, Rony E Duncan, J Sabura Allen, Susan M Sawyer, Daniel Le Grange, Elizabeth K Hughes
Little is known about the involvement of siblings in family-based treatment (FBT) for anorexia nervosa (AN). To explore the experience of families, adolescents who had completed FBT, their siblings, and parents were interviewed. Siblings reported that involvement in FBT enhanced their understanding of anorexia and that they supported their family in various ways. While siblings often wished they had attended more sessions, there was no consensus among parents and patients regarding sibling attendance and many were concerned about potential negative impacts on siblings...
April 23, 2018: Eating Disorders
https://www.readbyqxmd.com/read/29683772/adolescents-perceptions-of-the-quality-of-interpersonal-relationships-and-eating-disorder-symptom-severity-the-mediating-role-of-low-self-esteem-and-negative-mood
#3
Jade Pelletier Brochu, Dominique Meilleur, Giuseppina DiMeglio, Danielle Taddeo, Eric Lavoie, Julius Erdstein, Robert Pauzé, Caroline Pesant, Isabelle Thibault, Jean-Yves Frappier
Few studies have examined how the perceived quality of multiple interpersonal relationships is related to eating disorder (ED) symptom severity in adolescents and how psychological variables might influence these associations. The aim of this study is to determine whether the perceived level of trust, communication, and alienation in the relationship with one's mother, father, and peers are predictive of ED severity in adolescent females and to test the mediating effects of low self-esteem and negative mood on these associations...
April 23, 2018: Eating Disorders
https://www.readbyqxmd.com/read/29681866/study-protocol-using-deep-brain-stimulation-multimodal-neuroimaging-and-neuroethics-to-understand-and-treat-severe-enduring-anorexia-nervosa
#4
Rebecca J Park, Jessica C Scaife, Tipu Z Aziz
Background: Research suggests that altered eating and the pursuit of thinness in anorexia nervosa (AN) are, in part, a consequence of aberrant reward circuitry. The neural circuits involved in reward processing and compulsivity overlap significantly, and this has been suggested as a transdiagnostic factor underpinning obsessive compulsive disorder, addictions and eating disorders. The nucleus accumbens (NAcc) is central to both reward processing and compulsivity. In previous studies, deep-brain stimulation (DBS) to the NAcc has been shown to result in neural and symptomatic improvement in both obsessive compulsive disorder and addictions...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29681806/temporal-processing-of-joyful-and-disgusting-food-pictures-by-women-with-an-eating-disorder
#5
Caroline Gagnon, Catherine Bégin, Vincent Laflamme, Simon Grondin
The present study used the presentation of food pictures and judgements about their duration to assess the emotions elicited by food in women suffering from an eating disorder (ED). Twenty-three women diagnosed with an ED, namely anorexia (AN) or bulimia nervosa (BN), and 23 healthy controls (HC) completed a temporal bisection task and a duration discrimination task. Intervals were marked with emotionally pre-rated pictures of joyful and disgusting food, and pictures of neutral objects. The results showed that, in the bisection task, AN women overestimated the duration of food pictures in comparison to neutral ones...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29681582/subchondral-insufficiency-fracture-of-the-femoral-head-in-a-pregnant-woman-with-pre-existing-anorexia-nervosa
#6
Kyoko Kasahara, Tomohiro Mimura, Suzuko Moritani, Taku Kawasaki, Shinji Imai, Shunichiro Tsuji, Fuminori Kimura, Takashi Murakami
Subchondral insufficiency fracture (SIF) is a fragility fracture secondary to osteoporosis that leads to collapse of the femoral head with no evidence of osteonecrosis. SIF of the femoral head has been reported in adults of varying ages and both sexes, but it has never been reported to occur in pregnant women. Herein, we describe a 40-year-old primiparous patient with pre-existing anorexia nervosa who developed SIF of the femoral head in the third trimester. At 29 weeks of gestation, the patient complained of sudden pain on walking in both hips...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29680574/subcortical-volume-and-cortical-surface-architecture-in-women-with-acute-and-remitted-anorexia-nervosa-an-exploratory-neuroimaging-study
#7
Amy E Miles, Aristotle N Voineskos, Leon French, Allan S Kaplan
BACKGROUND: Anorexia nervosa (AN) is a highly heritable psychiatric disorder characterized by starvation and emaciation and associated with changes in brain structure. The precise nature of these changes remains unclear, as does their developmental time course and capacity for reversal with weight-restoration. In this comprehensive neuroimaging study, we sought to characterize these changes by measuring subcortical volume and cortical surface architecture in women with acute and remitted AN...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29676713/-deep-brain-stimulation-for-psychiatric-disorders
#8
M Figee, P R Schuurman, D Denys
- Deep brain stimulation (DBS) corrects pathological activity of neuropsychiatric brain networks with high frequency current via implanted brain electrodes.- DBS is an effective and safe treatment for therapy-refractory obsessive-compulsive disorder and potentially also for therapy-refractory major depressive disorder.- Experimental psychiatric indications for DBS are Tourette syndrome, addiction, anorexia nervosa, post-traumatic stress disorder, autism and schizophrenia.- DBS influences brain networks that are relevant for a variety of psychiatric symptoms...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29673720/-study-of-parental-bonding-in-childhood-in-children-and-adolescents-with-anorexia-nervosa
#9
A M H Albinhac, F A M Jean, M P Bouvard
INTRODUCTION: Anorexia nervosa constitutes a severe and complex eating disorder occurring principally in adolescence. It is one of the most deadly psychiatric disorders. Considering the multifactorial nature of anorexia nervosa, the important place of the family and the growing interest in the theory of attachment in eating disorders, parental bonding is questioned in anorexia nervosa. The main study goal is to analyze parental bonding in a population of children and adolescents with anorexia nervosa...
April 16, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29672273/bone-mineral-density-comparison-of-adolescents-with-constitutional-thinness-and-anorexia-nervosa
#10
Melis Pehlivantürk Kızılkan, Sinem Akgül, Orhan Derman, Nuray Kanbur
BACKGROUND: The negative impact of anorexia nervosa (AN) on bone health is well defined. However, there are very few studies evaluating the effect of constitutional thinness on bone health, especially in the adolescent period and in the male gender. The aim of this study is to compare the bone mineral density (BMD) measurements of adolescents with AN and with constitutional thinness. METHODS: Between April 2013 and March 2014, 40 adolescents with AN and 36 adolescents with constitutional thinness participated in the study...
April 19, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29668146/-adolescents-suffering-from-anorexia-nervosa-an-evidence-based-approach-of-the-parent-s-role-in-2018
#11
Sophie Vust, Solange Cook-Darzens, Françoise Lier, Anne-Emmanuelle Ambresin
A new paradigm in the management of adolescents with eating disorders promotes different treatment orientations aiming at increasing therapeutic effectiveness as well as offering a more integrated and coherent care for families. Particular attention is given to the process of refeeding to avoid the severe somatic sequelae of eating disorder and the risk of a chronic course for a disorder which is well known for its « addictive » power and influence. The parents and the need for a strong alliance with the healthcare team stand at the centre of this new paradigm...
April 18, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29665149/decision-making-impairment-in-anorexia-nervosa-new-insights-into-the-role-of-age-and-decision-making-style
#12
Valeria Giannunzio, Daniela Degortes, Elena Tenconi, Enrico Collantoni, Marco Solmi, Paolo Santonastaso, Angela Favaro
OBJECTIVE: Patients with anorexia nervosa (AN) often report difficulties in decision making, which may interfere with treatment. The aim of this study was to investigate decision making in a large sample of adolescent and adult patients with AN, by using the Iowa gambling task. METHOD: Participants were 611 female individuals (310 patients and 301 controls) who underwent neuropsychological and clinical assessment. RESULTS: Significantly poorer decision-making performance was observed in adult patients, whereas no difference emerged between affected and nonaffected adolescents...
April 17, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29659886/bone-parameters-in-anorexia-nervosa-and-athletic-amenorrhea-comparison-of-two-hypothalamic-amenorrhea-states
#13
Nurgun Kandemir, Meghan Slattery, Kathryn E Ackerman, Shreya Tulsiani, Amita Bose, Vibha Singhal, Charumathi Baskaran, Seda Ebrahimi, Mark Goldstein, Kamryn Eddy, Anne Klibanski, Madhusmita Misra
Purpose: We have reported low bone mineral density (BMD), impaired bone structure, and increased fracture risk in anorexia nervosa (AN) and normal-weight, oligo-amenorrheic athletes (OA). However, data directly comparing compartment-specific bone parameters in AN, OA and controls are lacking. Methods: 426 females 14-21.9 years old were included; 231 AN, 94 OA and 101 normal-weight eumenorrheic controls. Dual energy x-ray absorptiometry was used to assess areal BMD (aBMD) of the whole body less head (WBLH), spine, and hip...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29656932/a-higher-calorie-refeeding-protocol-does-not-increase-adverse-outcomes-in-adult-patients-with-eating-disorders
#14
Kylie Matthews, Jan Hill, Shane Jeffrey, Susan Patterson, Amanda Davis, Warren Ward, Michelle Palmer, Sandra Capra
BACKGROUND: Patients with eating disorders (EDs) are often considered a high-risk population to refeed. Current research advises using "start low, go slow" refeeding methods (∼1,000 kcal/day, advancing ∼500 kcal/day every 3 to 4 days) in adult patients with severe EDs to prevent the development of refeeding syndrome (RFS), typically characterized by decreases in serum electrolyte levels and fluid shifts. OBJECTIVE: To compare the incidence of RFS and related outcomes using a low-calorie protocol (LC) (1,000 kcal) or a higher-calorie protocol (HC) (1,500 kcal) in medically compromised adult patients with EDs...
April 12, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29656033/differences-in-the-theory-of-mind-profiles-of-patients-with-anorexia-nervosa-and-individuals-on-the-autism-spectrum-a-meta-analytic-review
#15
REVIEW
Jenni Leppanen, Felicity Sedgewick, Janet Treasure, Kate Tchanturia
BACKGROUND: This meta-analytic review examines the theory of mind profiles in both patients with anorexia nervosa (AN) and autistic individuals. METHODOLOGY: The studies examining theory of mind were divided into the following categories: emotional theory of mind, understanding simple social situations, understanding complex social interactions, and implicit social attribution. All included studies investigated differences between healthy control (HCs) individuals and people with AN or autistic people...
April 12, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29653375/feeling-fat-in-eating-disorders-testing-the-unique-relationships-between-feeling-fat-and-measures-of-disordered-eating-in-anorexia-nervosa-and-bulimia-nervosa
#16
Jake Linardon, Andrea Phillipou, David Castle, Richard Newton, Philippa Harrison, Leonardo L Cistullo, Scott Griffiths, Annemarie Hindle, Leah Brennan
Although widely discussed in theories of eating disorders, the experience of "feeling fat" in this population has received little research attention. This study tested the unique relationships between feeling fat and measures of problematic eating behaviours and attitudes. Data were analysed from individuals with anorexia nervosa (AN; n = 123) and bulimia nervosa (BN; n = 51). Correlations revealed considerable unshared variance between feeling fat and shape and weight over-evaluation and depressive symptoms...
April 10, 2018: Body Image
https://www.readbyqxmd.com/read/29653285/adipokines-and-bone-status-in-a-cohort-of-anorexic-patients
#17
Isabelle Legroux-Gérot, Jean Vignau, Odile Viltart, Pierre Hardouin, Christophe Chauveau, Bernard Cortet
INTRODUCTION: Bone loss in anorexia nervosa (AN) is multifactorial; its mechanisms are not yet clearly understood and may vary depending on disease duration and severity. To determine to what extent adipokines may be involved in the bone alterations found in anorexic patients, we evaluated plasma levels for leptin, adiponectin and Pref-1 against other clinical and biological parameters in a population of anorexic patients split according to weight and bone status. METHODS: Plasma concentrations of leptin, total adiponectin, high molecular weight (HMW) adiponectin, and Pref-1 were measured...
April 10, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29653254/interactions-between-risk-factors-in-the-prediction-of-onset-of-eating-disorders-exploratory-hypothesis-generating-analyses
#18
Eric Stice, Christopher D Desjardins
OBJECTIVE: Because no study has tested for interactions between risk factors in the prediction of future onset of each eating disorder, this exploratory study addressed this lacuna to generate hypotheses to be tested in future confirmatory studies. METHOD: Data from three prevention trials that targeted young women at high risk for eating disorders due to body dissatisfaction (N = 1271; M age 18.5, SD 4.2) and collected diagnostic interview data over 3-year follow-up were combined to permit sufficient power to predict onset of anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), and purging disorder (PD) using classification tree analyses, an analytic technique uniquely suited to detecting interactions...
March 17, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29651909/-anorexia-nervosa-in-males
#19
Pola Maria Heimann, Kerstin Konrad, Timo D Vloet
No abstract text is available yet for this article.
April 13, 2018: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/29627003/using-real-time-fmri-brain-computer-interfacing-to-treat-eating-disorders
#20
REVIEW
Moses O Sokunbi
Real-time functional magnetic resonance imaging based brain-computer interfacing (fMRI neurofeedback) has shown encouraging outcomes in the treatment of psychiatric and behavioural disorders. However, its use in the treatment of eating disorders is very limited. Here, we give a brief overview of how to design and implement fMRI neurofeedback intervention for the treatment of eating disorders, considering the basic and essential components. We also attempt to develop potential adaptations of fMRI neurofeedback intervention for the treatment of anorexia nervosa, bulimia nervosa and binge eating disorder...
May 15, 2018: Journal of the Neurological Sciences
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