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Anorexia nervosa

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https://www.readbyqxmd.com/read/29049935/intranasal-oxytocin-in-the-treatment-of-anorexia-nervosa-randomized-controlled-trial-during-re-feeding
#1
Janice Russell, Sarah Maguire, Glenn E Hunt, Alice Kesby, Anastasia Suraev, Jordyn Stuart, Jessica Booth, Iain S McGregor
BACKGROUND: Nutritional rehabilitation in anorexia nervosa (AN) is impeded by fear of food, eating and change leading to treatment resistance. Oxytocin (OT) exerts prosocial effects and modulates trust, fear, anxiety and neuroplasticity. The current placebo-controlled RCT examined the effects of intranasal oxytocin (IN-OT) in AN. The aim was to ascertain whether repeated doses of IN-OT enhance treatment outcomes in AN. METHODS: AN patients self-administered 36 IU IN-OT or placebo daily for 4-6 weeks during hospital treatment...
October 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29048300/intensive-family-exposure-based-cognitive-behavioral-treatment-for-adolescents-with-anorexia-nervosa
#2
Marina Iniesta Sepúlveda, Joshua M Nadeau, Megan K Whelan, Christina M Oiler, Amaya Ramos, Bradley C Riemann, Eric A Storch
BACKGROUND: Anorexia nervosa exhibits high comorbidity rates and shared features with anxiety disorders and obsessive-compulsive disorder. Anxiety-based etiological models have proposed that fear of eating-related stimuli is the central mechanism around which avoidance of food and food-related rituals are performed. Building on this approach, exposure-based interventions have demonstrated promising results. Limited evidence in adolescents encourages the evaluation of exposure approaches in this population...
November 2017: Psicothema
https://www.readbyqxmd.com/read/29046154/neural-network-alterations-across-eating-disorders-a-narrative-review-of-fmri-studies
#3
Trevor Steward, José M Menchón, Susana Jiménez-Murcia, Carles Soriano-Mas, Fernando Fernández-Aranda
Functional magnetic resonance imaging (fMRI) has provided insight on how neural abnormalities are related to the symptomatology of the eating disorders (EDs): anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). More specifically, an increasingly growing number of brain imaging studies has shed light on how functionally connected brain networks contribute not only to disturbed eating behavior, but also to transdiagnostic alterations in body/interoceptive perception, reward processing and executive functions...
October 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29044637/the-modeled-cost-effectiveness-of-family-based-and-adolescent-focused-treatment-for-anorexia-nervosa
#4
Long Khanh-Dao Le, Jan J Barendregt, Phillipa Hay, Susan M Sawyer, Elizabeth K Hughes, Cathrine Mihalopoulos
BACKGROUND: Anorexia nervosa (AN) is a prevalent, serious mental disorder. We aimed to evaluate the cost-effectiveness of family-based treatment (FBT) compared to adolescent-focused individual therapy (AFT) or no intervention within the Australian healthcare system. METHOD: A Markov model was developed to estimate the cost and disability-adjusted life-year (DALY) averted of FBT relative to comparators over 6 years from the health system perspective. The target population was 11-18 year olds with AN of relatively short duration...
October 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29044580/low-oxytocin-levels-are-related-to-alexithymia-in-anorexia-nervosa
#5
Cindy Schmelkin, Franziska Plessow, Jennifer J Thomas, Emily K Gray, Dean A Marengi, Reitumetse Pulumo, Lisseth Silva, Karen K Miller, Nouchine Hadjikhani, Debra L Franko, Kamryn T Eddy, Elizabeth A Lawson
OBJECTIVE: Anorexia nervosa is associated with social-emotional functioning deficits and low levels of the social neurohormone oxytocin, even after weight gain. The relationship between low oxytocin levels and social-emotional functioning impairment has not been studied. METHOD: We performed a cross-sectional study of 79 women (19 who were less than 85% of ideal body weight [IBW] with anorexia nervosa [AN], 26 who were 90-120% IBW with a history of AN [AN-WR], and 34 who were 90-120% IBW with no eating disorder history [H])...
October 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29043085/a-pilot-open-series-of-lamotrigine-in-dbt-treated-eating-disorders-characterized-by-significant-affective-dysregulation-and-poor-impulse-control
#6
Mary Ellen Trunko, Terry A Schwartz, Laura A Berner, Anne Cusack, Tiffany Nakamura, Ursula F Bailer, Joanna Y Chen, Walter H Kaye
BACKGROUND: There is little effective psychopharmacological treatment for individuals with eating disorders who struggle with pervasive, severe affective and behavioral dysregulation. METHODS: This pilot open series evaluated lamotrigine, a mood stabilizer, in the treatment of patients with eating disorders who did not respond adequately to antidepressant medications. Nine women with anorexia nervosa- or bulimia nervosa-spectrum eating disorders in partial hospital or intensive outpatient dialectical behavior therapy (DBT)-based eating disorder treatment took lamotrigine for 147 ± 79 days (mean final dose = 161...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/29042824/family-profiles-in-eating-disorders-family-functioning-and-psychopathology
#7
Luca Cerniglia, Silvia Cimino, Mimma Tafà, Eleonora Marzilli, Giulia Ballarotto, Fabrizia Bracaglia
Research has studied family functioning in families of patients suffering from eating disorders (EDs), particularly investigating the associations between mothers' and daughters' psychopathological symptoms, but limited studies have examined whether there are specific maladaptive psychological profiles characterizing the family as a whole when it includes adolescents with anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Through the collaboration of a network of public and private consultants, we recruited n=181 adolescents diagnosed for EDs (n=61 with AN, n=60 with BN, and n=60 with BEDs) and their parents...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29038330/can-growth-hormone-treatment-improve-growth-in-children-with-severe-growth-failure-due-to-anorexia-nervosa-a-preliminary-pilot-study
#8
Juliane Leger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Catherine Doyen, Emmanuel Ecosse, Jean-Claude Carel, Marie-France Le Heuzey
BACKGROUND/AIMS: Growth failure is a difficult, but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN. METHODS: We carried out a retrospective observational study. Ten girls diagnosed with AN at 10.0±1.9 years, with prolonged severe growth failure (HV <2.5 cm/year for at least 18 months) at the age of 13...
October 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29034536/family-functioning-and-relationship-quality-for-adolescents-in-family-based-treatment-with-severe-anorexia-nervosa-compared-with-non-clinical-adolescents
#9
Andrew Wallis, Jane Miskovic-Wheatley, Sloane Madden, Paul Rhodes, Ross D Crosby, Li Cao, Stephen Touyz
This longitudinal study explored family functioning and relationship quality for adolescents with severe anorexia nervosa (AN). An important outcome given healthy family functioning supports effective adolescent development. Fifty-four female adolescents and their parents, treated with family-based treatment after inpatient admission, and 49 non-clinical age-matched adolescents and their parents were compared at assessment and 6 months after session 20. At baseline, AN group mothers and fathers reported poorer family function...
October 16, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29034241/bone-mineral-density-after-weight-gain-in-160-patients-with-anorexia-nervosa
#10
Najate Achamrah, Moïse Coëffier, Pierre Jésus, Jocelyne Charles, Agnès Rimbert, Pierre Déchelotte, Sébastien Grigioni
Low bone mineral density (BMD) is a frequent complication in anorexia nervosa (AN). There are controversial points of views regarding the restoration of bone mineralization after recovery in AN. We aimed to assess changes of BMD at 3 years in patients with AN and to explore the relationships between body composition, physical activity, and BMD. Patients with AN were included from 2009 to 2011 in a first visit (T0) with evaluation of weight, height, body mass index (BMI), body composition [fat mass (FM) and fat-free mass], and BMD...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29033054/temporary-stages-and-motivational-variables-two-complementary-perspectives-in-the-help-seeking-process-for-mental-disorders
#11
Gema Del Valle Del Valle, Carmen Carrió, Amparo Belloch
INTRODUCTION: Help-seeking for mental disorders is a complex process, which includes different temporary stages, and in which the motivational variables play an especially relevant role. However, there is a lack of instruments to evaluate in depth both the temporary and motivational variables involved in the help-seeking process. This study aims to analyse in detail these two sets of variables, using a specific instrument designed for the purpose, to gain a better understanding of the process of treatment seeking...
October 9, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29031167/impaired-central-coherence-in-patients-with-anorexia-nervosa
#12
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Hiroko Kubo, Masashi Ohta, Yukio Tada, Yukiko Tomioka, Shinya Watanabe, Masatoshi Inoshita, Makoto Kinoshita, Tetsuro Ohmori
The purpose of this study was to investigate the characteristics of central coherence in patients with anorexia nervosa (AN). 22 female patients with AN (median age = 31.50 (QD = 8.13) years) and 33 female healthy controls (HC) (median age = 28.00 (QD = 8.50) years) participated in the study. Their central coherence was assessed with the Rey Complex Figure Task (RCFT). Clinical symptoms were evaluated with the Beck Depression Inventory-II and the State-Trait Anxiety Inventory-Form JYZ. The results showed that AN patients' Central Coherence Index and accuracy scores in copy, 3-min delayed recall and 30-min delayed recall tasks of the RCFT were significantly lower than those of HC...
September 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29026589/a-retrospective-analysis-of-biochemical-and-haematological-parameters-in-patients-with-eating-disorders
#13
Leanne J Barron, Robert F Barron, Jeremy C S Johnson, Ingrid Wagner, Cameron J B Ward, Shannon R B Ward, Faye M Barron, Warren K Ward
BACKGROUND: The objective of the study was to determine whether levels of biochemical and haematological parameters in patients with eating disorders (EDs) varied from the general population. Whilst dietary restrictions can lead to nutritional deficiencies, specific abnormalities may be relevant to the diagnosis, pathogenesis and treatment of EDs. METHODS: With ethics approval and informed consent, a retrospective chart audit was conducted of 113 patients with EDs at a general practice in Brisbane, Australia...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29025688/altered-medial-frontal-feedback-learning-signals-in-anorexia-nervosa
#14
Fabio Bernardoni, Daniel Geisler, Joseph A King, Amir-Homayoun Javadi, Franziska Ritschel, Julia Murr, Andrea M F Reiter, Veit Rössner, Michael N Smolka, Stefan Kiebel, Stefan Ehrlich
BACKGROUND: In their relentless pursuit of thinness, individuals with anorexia nervosa (AN) engage in maladaptive behaviors (restrictive food choices and overexercising) that may originate in altered decision making and learning. METHODS: In this functional magnetic resonance imaging study, we employed computational modeling to elucidate the neural correlates of feedback learning and value-based decision making in 36 female patients with AN and 36 age-matched healthy volunteers (12-24 years)...
August 30, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29019520/feelings-and-perceptions-of-women-recovering-from-anorexia-nervosa-regarding-their-eating-behavior
#15
Nathalia Petry, Francisco de Assis Guedes de Vasconcelos, Larissa da Cunha Feio Costa
According to the phenomenological approach, observing a phenomenon through the perspective of those who lived it may be necessary to acquire fully comprehension of it. Therefore, to fully understand the eating behavior during anorexia nervosa and during its recovery, this study investigated individual perceptions and feelings of three women recovering from anorexia nervosa. This study is characterized as a qualitative research with phenomenological approach. The data were collected through interviews and analyzed following steps proposed by phenomenology researchers...
October 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29018381/the-role-of-working-memory-for-cognitive-control-in-anorexia-nervosa-versus-substance-use-disorder
#16
REVIEW
Samantha J Brooks, Sabina G Funk, Susanne Y Young, Helgi B Schiöth
Prefrontal cortex executive functions, such as working memory (WM) interact with limbic processes to foster impulse control. Such an interaction is referred to in a growing body of publications by terms such as cognitive control, cognitive inhibition, affect regulation, self-regulation, top-down control, and cognitive-emotion interaction. The rising trend of research into cognitive control of impulsivity, using various related terms reflects the importance of research into impulse control, as failure to employ cognitions optimally may eventually result in mental disorder...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28994215/psychometric-properties-of-the-chinese-version-of-the-eating-attitudes-test-in-young-female-patients-with-eating-disorders-in-mainland-china
#17
Qing Kang, Raymond C K Chan, Xiaoping Li, Jon Arcelus, Ling Yue, Jiabin Huang, Lian Gu, Qing Fan, Haiyin Zhang, Zeping Xiao, Jue Chen
The study aimed to investigate the reliability and validity of the Chinese version of the eating attitudes test (EAT-26) among female adolescents and young adults in Mainland China. This scale was administered to 396 female eating disorder patients and 406 noneating disorder healthy controls, in addition 35 healthy controls completed a retest after a 4-week intervals. Tests for reliability, convergent validity and receiver operating characteristic analysis were performed to detect the psychometric properties...
October 9, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28992897/inflammatory-bowel-disease-and-eating-disorders-a-systematized-review-of-comorbidity
#18
REVIEW
L Ilzarbe, M Fàbrega, R Quintero, A Bastidas, L Pintor, J García-Campayo, F Gomollón, D Ilzarbe
OBJECTIVE: Research has shown that there is an association between Inflammatory Bowel Disease, anxiety and mood disorders, however little is known about their association with Eating Disorders. In this paper we will present a case of a young female with a comorbid diagnosis of Inflammatory Bowel Disease and Eating Disorder, and then discuss the results from a systematic review of the literature, describing published cases of patients with the same condition. METHODS: A systematized review of the literature was conducted according to MOOSE guidelines...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28992891/patterns-of-medical-utilization-before-the-first-hospitalization-for-women-with-anorexia-nervosa-in-taiwan
#19
Yen-Ni Hung, Chian-Jue Kuo, Shu-Yu Yang, Ming-Chyi Huang, Ying-Yeh Chen, Shih-Ku Lin, Kuan-Yu Chen
OBJECTIVE: The aim of this paper was to analyze medical utilization patterns of female patients with anorexia nervosa before their first inpatient care visit for anorexia nervosa using the National Health Insurance Research Database (NHIRD) of Taiwan. METHOD: We selected female anorexia nervosa patients (n=239) and control participants hospitalized for peptic ulcers (n=478) or appendectomy (n=478) who were matched by age and incident year from two subsets of the NHIRD...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28992582/fat-or-fiction-effects-of-body-size-eating-pathology-and-sex-upon-the-body-schema-of-an-undergraduate-population
#20
Sophie J Wignall, Nicole A Thomas, Michael E R Nicholls
Although there is a growing consensus that women with anorexia nervosa have a distorted body schema, the origins of this disturbance remain uncertain. The present investigation examined the effects of body size, eating pathology, and sex upon the body schema of an at-risk, undergraduate population. In Study 1, 98 participants mentally simulated their passage through apertures. When aperture width was manipulated, narrow and broad women over- and under-estimated their spatial requirements for passage, respectively...
October 6, 2017: Body Image
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